Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	RHCG ATP7A ABCA13 SPNS2 TMC6 SLC22A15 SLC44A2 SPNS3 ATP9A CALHM4 ITPR1 CLPTM1L ABCG1 ATP6V0A4 PITPNM3 PEX2 ATP12A SLC14A2 SLC4A5	1.39e-05	1289	98	19	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	RHCG ATP7A ABCA13 SPNS2 TMC6 SLC22A15 SLC44A2 SPNS3 CALHM4 ITPR1 ABCG1 ATP6V0A4 PEX2 ATP12A SLC14A2 SLC4A5	1.93e-04	1180	98	16	GO:0022857
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ATP7A ABCA13 ABCG1 ATP6V0A4 ATP12A	2.01e-04	109	98	5	GO:0042626
GeneOntologyMolecularFunction	lipid transporter activity	ABCA13 SPNS2 ATP9A CLPTM1L ABCG1 PITPNM3	4.12e-04	196	98	6	GO:0005319
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP7A ATP6V0A4 ATP12A	7.28e-04	36	98	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP7A ATP6V0A4 ATP12A	7.28e-04	36	98	3	GO:0015662
GeneOntologyBiologicalProcess	lipid biosynthetic process	SMG1 OGT SPNS2 CDS2 ACSM1 SLC44A2 MTMR1 ST8SIA1 KAT2B ABCG1 FAR2 ORMDL2 SCD MTM1 NUS1 CERS3 PITPNM3 PEX2	6.42e-08	813	100	18	GO:0008610
Domain	Rhs_assc_core	TENM2 TENM3	8.48e-05	3	100	2	IPR022385
Domain	ARM-type_fold	SMG1 CLTCL1 ITPR1 FOCAD RANBP17 NF1 ANKAR PRKDC UNC79	8.58e-05	339	100	9	IPR016024
Domain	Tox-GHH_dom	TENM2 TENM3	1.69e-04	4	100	2	IPR028916
Domain	Ten_N	TENM2 TENM3	1.69e-04	4	100	2	IPR009471
Domain	Ten_N	TENM2 TENM3	1.69e-04	4	100	2	PF06484
Domain	TENEURIN_N	TENM2 TENM3	1.69e-04	4	100	2	PS51361
Domain	Tox-GHH	TENM2 TENM3	1.69e-04	4	100	2	PF15636
Domain	TPR-like_helical_dom	SEL1L OGT CLTCL1 IFIT2 WDR19 PDCD11 PRKDC	2.57e-04	233	100	7	IPR011990
Domain	FATC	SMG1 PRKDC	2.81e-04	5	100	2	PF02260
Domain	YD	TENM2 TENM3	2.81e-04	5	100	2	IPR006530
Domain	FAT	SMG1 PRKDC	4.20e-04	6	100	2	PS51189
Domain	FATC	SMG1 PRKDC	4.20e-04	6	100	2	PS51190
Domain	FATC_dom	SMG1 PRKDC	4.20e-04	6	100	2	IPR003152
Domain	PIK_FAT	SMG1 PRKDC	4.20e-04	6	100	2	IPR014009
Domain	FATC	SMG1 PRKDC	4.20e-04	6	100	2	SM01343
Domain	HRM	CELSR1 CELSR3 ADGRF3	4.43e-04	28	100	3	PF02793
Domain	Clathrin	CLTCL1 WDR19	5.86e-04	7	100	2	PF00637
Domain	-	RHCG SLC14A2	5.86e-04	7	100	2	1.10.3430.10
Domain	Ammonium/urea_transptr	RHCG SLC14A2	5.86e-04	7	100	2	IPR029020
Domain	-	ATP7A ATP9A ATP12A	6.60e-04	32	100	3	3.40.1110.10
Domain	-	ATP7A ATP9A ATP12A	6.60e-04	32	100	3	2.70.150.10
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 WDR19	7.78e-04	8	100	2	IPR000547
Domain	GPS	CELSR1 CELSR3 ADGRF3	7.90e-04	34	100	3	SM00303
Domain	HAD-like_dom	ATP7A ATP9A PITPNM3 ATP12A	8.55e-04	79	100	4	IPR023214
Domain	GPS	CELSR1 CELSR3 ADGRF3	8.61e-04	35	100	3	PF01825
Domain	ATPase_P-typ_cyto_domN	ATP7A ATP9A ATP12A	8.61e-04	35	100	3	IPR023299
Domain	-	SEL1L OGT CLTCL1 IFIT2 WDR19 PDCD11	8.65e-04	207	100	6	1.25.40.10
Domain	P_typ_ATPase	ATP7A ATP9A ATP12A	9.35e-04	36	100	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP7A ATP9A ATP12A	9.35e-04	36	100	3	IPR018303
Domain	GPS	CELSR1 CELSR3 ADGRF3	9.35e-04	36	100	3	PS50221
Domain	ATPASE_E1_E2	ATP7A ATP9A ATP12A	9.35e-04	36	100	3	PS00154
Domain	GPS	CELSR1 CELSR3 ADGRF3	1.01e-03	37	100	3	IPR000203
Domain	ATPase_P-typ_transduc_dom_A	ATP7A ATP9A ATP12A	1.01e-03	37	100	3	IPR008250
Domain	E1-E2_ATPase	ATP7A ATP9A ATP12A	1.01e-03	37	100	3	PF00122
Domain	LAM_G_DOMAIN	CELSR1 CELSR3 EGFLAM	1.10e-03	38	100	3	PS50025
Domain	G_PROTEIN_RECEP_F2_1	CELSR1 CELSR3 ADGRF3	1.27e-03	40	100	3	PS00649
Domain	GPCR_2_extracellular_dom	CELSR1 CELSR3 ADGRF3	1.27e-03	40	100	3	IPR001879
Domain	Laminin_G_2	CELSR1 CELSR3 EGFLAM	1.27e-03	40	100	3	PF02210
Domain	G_PROTEIN_RECEP_F2_3	CELSR1 CELSR3 ADGRF3	1.27e-03	40	100	3	PS50227
Domain	TPR-contain_dom	OGT IFIT2 WDR19 PDCD11 PRKDC	1.28e-03	150	100	5	IPR013026
Domain	GAIN_dom_N	CELSR1 CELSR3	1.51e-03	11	100	2	IPR032471
Domain	GAIN	CELSR1 CELSR3	1.51e-03	11	100	2	PF16489
Domain	LamG	CELSR1 CELSR3 EGFLAM	1.68e-03	44	100	3	SM00282
Domain	NHL	TENM2 TENM3	2.13e-03	13	100	2	PS51125
Domain	G_PROTEIN_RECEP_F2_2	CELSR1 CELSR3 ADGRF3	2.43e-03	50	100	3	PS00650
Domain	7tm_2	CELSR1 CELSR3 ADGRF3	2.43e-03	50	100	3	PF00002
Domain	Myotubularin-like_Pase_dom	MTMR1 MTM1	2.48e-03	14	100	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR1 MTM1	2.48e-03	14	100	2	PS51339
Domain	Myotubularin_fam	MTMR1 MTM1	2.48e-03	14	100	2	IPR030564
Domain	Myotub-related	MTMR1 MTM1	2.48e-03	14	100	2	PF06602
Domain	PI3/4_kinase_CS	SMG1 PRKDC	2.85e-03	15	100	2	IPR018936
Domain	GRAM	MTMR1 MTM1	3.24e-03	16	100	2	SM00568
Domain	-	SMG1 PRKDC	3.24e-03	16	100	2	1.10.1070.11
Domain	PI3Kc	SMG1 PRKDC	3.24e-03	16	100	2	SM00146
Domain	CarboxyPept-like_regulatory	TENM2 TENM3	3.66e-03	17	100	2	IPR008969
Domain	Laminin_G	CELSR1 CELSR3 EGFLAM	3.71e-03	58	100	3	IPR001791
Domain	GPCR_2_secretin-like	CELSR1 CELSR3 ADGRF3	4.09e-03	60	100	3	IPR000832
Domain	GPCR_2-like	CELSR1 CELSR3 ADGRF3	4.09e-03	60	100	3	IPR017981
Domain	PI3/4_kinase_cat_dom	SMG1 PRKDC	4.11e-03	18	100	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 PRKDC	4.11e-03	18	100	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PRKDC	4.11e-03	18	100	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 PRKDC	4.11e-03	18	100	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PRKDC	4.11e-03	18	100	2	PS00916
Domain	EGF_CA	TENM2 CELSR1 CELSR3 EGFLAM	4.19e-03	122	100	4	SM00179
Domain	G_PROTEIN_RECEP_F2_4	CELSR1 CELSR3 ADGRF3	4.28e-03	61	100	3	PS50261
Domain	EGF-like_Ca-bd_dom	TENM2 CELSR1 CELSR3 EGFLAM	4.44e-03	124	100	4	IPR001881
Domain	-	ATP7A ATP9A PITPNM3	4.90e-03	64	100	3	3.40.50.1000
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	OGT TMC6 CHD3 SESN1 TASOR2 PCNX2 RANBP17 PHKB PCYOX1L ABCG1 PNPLA6 ANKAR SLC4A5 TRAPPC9 AFF4 NLK ADSS1	1.75e-06	1489	103	17	28611215
Pubmed	Molecular characterization of chromosomal band 5p15.33: a recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus.	TERT CLPTM1L	8.69e-06	2	103	2	23137523
Pubmed	Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer: a case-control study in northeast Chinese male population.	TERT CLPTM1L	8.69e-06	2	103	2	24861918
Pubmed	Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: a meta-analysis.	TERT CLPTM1L	8.69e-06	2	103	2	23707794
Pubmed	Association between CLPTM1L-TERT rs401681 polymorphism and pancreatic cancer risk among Chinese Han population.	TERT CLPTM1L	8.69e-06	2	103	2	24577890
Pubmed	Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.	TERT CLPTM1L	8.69e-06	2	103	2	25487306
Pubmed	Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population.	TERT CLPTM1L	8.69e-06	2	103	2	25966219
Pubmed	TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications.	TERT CLPTM1L	8.69e-06	2	103	2	23226346
Pubmed	The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema.	TERT CLPTM1L	8.69e-06	2	103	2	21622582
Pubmed	TERT-rs33963617 and CLPTM1L-rs77518573 reduce the risk of non-small cell lung cancer in Chinese population.	TERT CLPTM1L	8.69e-06	2	103	2	31935503
Pubmed	No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk.	TERT CLPTM1L	8.69e-06	2	103	2	20570912
Pubmed	The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.	TERT CLPTM1L	8.69e-06	2	103	2	28025427
Pubmed	rs401681 and rs402710 confer lung cancer susceptibility by regulating TERT expression instead of CLPTM1L in East Asian populations.	TERT CLPTM1L	8.69e-06	2	103	2	29939218
Pubmed	Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations.	TERT CLPTM1L	8.69e-06	2	103	2	26621837
Pubmed	The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.	TERT CLPTM1L	8.69e-06	2	103	2	20700438
Pubmed	Polymorphisms of the TERT-CLPTM1L Gene Are Associated with Pharynx-Larynx Cancer.	TERT CLPTM1L	8.69e-06	2	103	2	31429604
Pubmed	Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case-control study in a Chinese non-smoking female population.	TERT CLPTM1L	8.69e-06	2	103	2	25037574
Pubmed	Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.	TERT CLPTM1L	8.69e-06	2	103	2	20802237
Pubmed	A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.	TERT CLPTM1L	8.69e-06	2	103	2	26545403
Pubmed	Genetic variations in TERT-CLPTM1L genes and risk of lung cancer in Chinese women nonsmokers.	TERT CLPTM1L	8.69e-06	2	103	2	23738012
Pubmed	Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme.	TERT CLPTM1L	8.69e-06	2	103	2	21332924
Pubmed	Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.	TERT CLPTM1L	8.69e-06	2	103	2	19151717
Pubmed	Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population.	TERT CLPTM1L	8.69e-06	2	103	2	23368278
Pubmed	Genetic variant rs401681 at 5p15.33 modifies susceptibility to lung cancer but not esophageal squamous cell carcinoma.	TERT CLPTM1L	8.69e-06	2	103	2	24386361
Pubmed	Genetic variations in the TERT and CLPTM1L gene region and gastrointestinal stromal tumors risk.	TERT CLPTM1L	8.69e-06	2	103	2	26372813
Pubmed	Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.	TERT CLPTM1L	8.69e-06	2	103	2	21771723
Pubmed	TERT-CLPTM1L Rs401681 C>T polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population.	TERT CLPTM1L	8.69e-06	2	103	2	25007268
Pubmed	A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.	TERT CLPTM1L	8.69e-06	2	103	2	22037553
Pubmed	TERT gene harbors multiple variants associated with pancreatic cancer susceptibility.	TERT CLPTM1L	8.69e-06	2	103	2	25940397
Pubmed	Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk.	TERT CLPTM1L	8.69e-06	2	103	2	21993562
Pubmed	Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.	TERT CLPTM1L	8.69e-06	2	103	2	22370939
Pubmed	Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.	TERT CLPTM1L	8.69e-06	2	103	2	23555636
Pubmed	Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair.	TERT CLPTM1L	8.69e-06	2	103	2	24615621
Pubmed	Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population.	TERT CLPTM1L	8.69e-06	2	103	2	23908149
Pubmed	Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects.	TERT CLPTM1L	8.69e-06	2	103	2	22893025
Pubmed	Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population.	TERT CLPTM1L	8.69e-06	2	103	2	19369581
Pubmed	Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry.	TERT CLPTM1L	8.69e-06	2	103	2	22134622
Pubmed	Association of TERT-CLPTM1L and 8q24 Common Genetic Variants with Gallbladder Cancer Susceptibility and Prognosis in North Indian Population.	TERT CLPTM1L	8.69e-06	2	103	2	29450669
Pubmed	Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells.	MTMR1 MTM1	8.69e-06	2	103	2	12217958
Pubmed	Polymorphisms of TERT and CLPTM1L and the risk of hepatocellular carcinoma in Chinese males.	TERT CLPTM1L	8.69e-06	2	103	2	25339005
Pubmed	The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population.	TERT CLPTM1L	8.69e-06	2	103	2	23359026
Pubmed	Fine mapping of chromosome 5p15.33 identifies novel lung cancer susceptibility loci in Han Chinese.	TERT CLPTM1L	8.69e-06	2	103	2	28335076
Pubmed	Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population.	TERT CLPTM1L	8.69e-06	2	103	2	23433592
Pubmed	Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.	TERT CLPTM1L	8.69e-06	2	103	2	25027329
Pubmed	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.	APOBEC1 NF1	2.60e-05	3	103	2	11727199
Pubmed	DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase.	TERT PRKDC	2.60e-05	3	103	2	15190070
Pubmed	Genomic organization of a 225-kb region in Xq28 containing the gene for X-linked myotubular myopathy (MTM1) and a related gene (MTMR1).	MTMR1 MTM1	2.60e-05	3	103	2	9828128
Pubmed	The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.	CELSR1 CELSR3	2.60e-05	3	103	2	11677057
Pubmed	Lung cancer susceptibility locus at 5p15.33.	TERT CLPTM1L	2.60e-05	3	103	2	18978790
Pubmed	An extended genome-wide association study identifies novel susceptibility loci for nasopharyngeal carcinoma.	TERT CLPTM1L	2.60e-05	3	103	2	27436580
Pubmed	DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.	TERT PRKDC	5.19e-05	4	103	2	17145779
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM2 TENM3	5.19e-05	4	103	2	10225957
Pubmed	Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases.	MTMR1 MTM1	5.19e-05	4	103	2	12925573
Pubmed	Functional redundancy in the myotubularin family.	MTMR1 MTM1	5.19e-05	4	103	2	11846405
Pubmed	The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.	CELSR1 CELSR3	5.19e-05	4	103	2	37224017
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM2 TENM3	5.19e-05	4	103	2	12000766
Pubmed	Developmental expression profiles of Celsr (Flamingo) genes in the mouse.	CELSR1 CELSR3	5.19e-05	4	103	2	11850187
Pubmed	Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.	TERT CLPTM1L	5.19e-05	4	103	2	21081471
Pubmed	Inherited genetic variants associated with occurrence of multiple primary melanoma.	TERT CLPTM1L	5.19e-05	4	103	2	25837821
Pubmed	Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.	OGT EPG5 GPR161 KAT2B	5.41e-05	69	103	4	32238831
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEL1L ATP9A ITPR1 SEMA3A GSTM3 CLPTM1L PCYOX1L SNX14 RINT1 CELSR1 NF1 CELSR3 TENM3	5.60e-05	1201	103	13	35696571
Pubmed	Genome-wide association study identifies multiple loci associated with bladder cancer risk.	TERT CLPTM1L SLC14A2	6.24e-05	26	103	3	24163127
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	ORC2 RINT1 TENM3 SLC4A5 NLK	6.71e-05	142	103	5	11812828
Pubmed	Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.	TERT CLPTM1L	8.64e-05	5	103	2	19955392
Pubmed	A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.	MTMR1 MTM1	8.64e-05	5	103	2	8640223
Pubmed	A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.	TERT CLPTM1L	8.64e-05	5	103	2	20101243
Pubmed	Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour.	TERT CLPTM1L	8.64e-05	5	103	2	21617256
Pubmed	DNA damage activates p53 through a phosphorylation-acetylation cascade.	KAT2B PRKDC	8.64e-05	5	103	2	9744860
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR26 GPR139 GPR161 ADGRF3	9.19e-05	79	103	4	12679517
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CLTCL1 UBE3B TMC6 REV3L PCNX2 FOCAD CELSR1 PNPLA6 CELSR3 PDCD11 PRKDC TRAPPC9	1.07e-04	1105	103	12	35748872
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	CELSR1 CELSR3 ADGRF3	1.29e-04	33	103	3	25713288
Pubmed	Dystroglycan is a scaffold for extracellular axon guidance decisions.	CELSR1 CELSR3	1.29e-04	6	103	2	30758284
Pubmed	A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.	TERT CLPTM1L	1.29e-04	6	103	2	19836008
Pubmed	Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.	TERT CLPTM1L	1.29e-04	6	103	2	20543847
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ATP7A UBXN8 ATP9A ITPR1 SNX14 RINT1 COG6 SCD	1.31e-04	504	103	8	34432599
Pubmed	Defining the membrane proteome of NK cells.	ATP7A CLTCL1 CDS2 ITPR1 ORC2 CLPTM1L PCYOX1L NF1 PNPLA6 SCD PEX2 PRKDC	1.79e-04	1168	103	12	19946888
Pubmed	Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.	CELSR1 CELSR3	1.81e-04	7	103	2	17937400
Pubmed	The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles.	TENM2 TENM3	1.81e-04	7	103	2	10625539
Pubmed	Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.	ATP9A MTM1	1.81e-04	7	103	2	18454193
Pubmed	The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.	TENM2 TENM3	1.81e-04	7	103	2	12915301
Pubmed	Genetic correction of PSA values using sequence variants associated with PSA levels.	TERT CLPTM1L	1.81e-04	7	103	2	21160077
Pubmed	Control of TurboID-dependent biotinylation intensity in proximity ligation screens.	SEL1L CDS2 ITPR1 ORMDL2	2.29e-04	100	103	4	36966971
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	SMG1 CDS2 RANBP17 KAT2B EXOC3L1	2.38e-04	186	103	5	33637726
Pubmed	New common variants affecting susceptibility to basal cell carcinoma.	TERT CLPTM1L	2.40e-04	8	103	2	19578363
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	SMG1 PRKDC	2.40e-04	8	103	2	20810650
Pubmed	Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.	TENM2 TENM3	2.40e-04	8	103	2	10331952
Pubmed	Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.	TERT CLPTM1L	3.08e-04	9	103	2	19654303
Pubmed	Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.	MTMR1 MTM1	3.85e-04	10	103	2	9736772
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	SMG1 PRKDC	3.85e-04	10	103	2	18160036
Pubmed	A role of DNA-PK for the metabolic gene regulation in response to insulin.	KAT2B PRKDC	3.85e-04	10	103	2	19303849
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	TENM2 TENM3	3.85e-04	10	103	2	38713721
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ATP7A UBXN8 MTMR1 ITPR1 WDR19 GSTM3 CLPTM1L CACTIN NAA35 RINT1 PNPLA6 SCD PDCD11	4.53e-04	1487	103	13	33957083
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	SMG1 PRKDC	4.69e-04	11	103	2	20427287
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	CELSR1 CELSR3	4.69e-04	11	103	2	25024228
Pubmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	UBE3B SNX14 NF1	5.02e-04	52	103	3	30655611
Pubmed	Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.	CELSR1 CELSR3	5.62e-04	12	103	2	11891983
Pubmed	Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.	CELSR1 CELSR3	5.62e-04	12	103	2	20631168
Pubmed	Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.	SEMA3A NF1 CELSR3	5.92e-04	55	103	3	32561725
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	ETFDH REV3L SCD	6.57e-04	57	103	3	21886157
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	CDS2 SLC44A2 ATP9A TASOR2 SNX14 PNPLA6 SCD	7.27e-04	499	103	7	22810586
Interaction	HCST interactions	ATP7A CDS2 MTMR1 FOCAD NF1 PNPLA6 FAR2 ATP12A	6.66e-06	205	97	8	int:HCST
Interaction	CX3CL1 interactions	ATP7A CLTCL1 TENM3 NUS1 ATP12A	2.36e-05	71	97	5	int:CX3CL1
Interaction	HS3ST4 interactions	CLTCL1 ATP12A HS3ST2	2.99e-05	13	97	3	int:HS3ST4
Cytoband	16p12.3	SMG1 ACSM1 GPR139	6.24e-05	34	103	3	16p12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	SMG1 ACSM1 GPR139 HS3ST2	6.30e-04	172	103	4	chr16p12
Cytoband	6q22.1	CALHM4 NUS1	1.95e-03	29	103	2	6q22.1
Cytoband	5q34	TENM2 RANBP17	2.37e-03	32	103	2	5q34
Cytoband	5p15.33	TERT CLPTM1L	2.37e-03	32	103	2	5p15.33
Cytoband	10q26.13	PRLHR GPR26	3.32e-03	38	103	2	10q26.13
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	3.93e-05	3	66	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	3.93e-05	3	66	2	1189
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR1 MTM1	1.34e-03	15	66	2	903
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#2_top-relative-expression-ranked_1000	CHD3 REV3L FRMD4B ZFPM2 ITPR1 SEMA3A	4.87e-06	97	95	6	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k2_1000
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	SEL1L SMG1 IL12RB2 SCD NUS1 PDCD11	3.44e-06	176	103	6	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CLTCL1 ABCA13 TFR2 GSTM3 SERPINB10 FAR2	5.66e-06	192	103	6	072281344d58e85c9a290750b488d0c101f75d54
ToppCell	severe-immature_Neutrophil\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CLTCL1 ABCA13 SLC22A15 ATP9A FAR2 SCD	7.15e-06	200	103	6	a9b87accdaa6956116ab82427e1330e8f007ef94
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IFIT2 FRMD4B SEMA3A GPR161 SERPINB10	8.47e-06	119	103	5	e868453c02dcf0e07821886b81ca739887d43c67
Disease	sphingolipidosis (implicated_via_orthology)	SPNS2 SPNS3	3.27e-05	3	98	2	DOID:1927 (implicated_via_orthology)
Disease	hypokalemia (biomarker_via_orthology)	RHCG ATP12A	3.27e-05	3	98	2	DOID:4500 (biomarker_via_orthology)
Disease	head and neck carcinoma, lung cancer	TERT CLPTM1L	6.52e-05	4	98	2	MONDO_0002038, MONDO_0008903
Disease	gallbladder carcinoma (is_implicated_in)	TERT CLPTM1L	1.08e-04	5	98	2	DOID:4948 (is_implicated_in)
Disease	Uterine leiomyoma	TERT SESN1 ITPR1 COG6	2.45e-04	91	98	4	HP_0000131
Disease	Lymphoid leukemia	TERT CLPTM1L	3.02e-04	8	98	2	C0023448
Disease	Inherited neuropathies	ATP7A ITPR1 PNPLA6	3.21e-04	40	98	3	C0598589
Disease	response to simvastatin, myopathy	ABCA13 SPNS3 FAR2	3.46e-04	41	98	3	EFO_0004145, GO_1903491
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR1 MTM1	3.87e-04	9	98	2	DOID:0111225 (implicated_via_orthology)
Disease	acute myeloid leukemia (is_marker_for)	TERT TFR2 NF1	5.86e-04	49	98	3	DOID:9119 (is_marker_for)
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	SPNS2 SPNS3	9.68e-04	14	98	2	DOID:14503 (implicated_via_orthology)
Disease	Moyamoya Disease	ATP7A NF1	1.44e-03	17	98	2	C0026654
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	TERT ZFPM2	1.61e-03	18	98	2	EFO_1000649, HP_0000131
Disease	Antihypertensive use measurement	UBE3B ETFDH NLGN1 ZFPM2 KAT2B	1.94e-03	265	98	5	EFO_0009927
Disease	electroencephalogram measurement	FRMD4B PCNX2 FOCAD	1.94e-03	74	98	3	EFO_0004357
Disease	esophagus squamous cell carcinoma (is_marker_for)	TERT CLPTM1L KAT2B	1.94e-03	74	98	3	DOID:3748 (is_marker_for)
Disease	non-small cell lung carcinoma	TERT CLPTM1L ADGRF3	2.02e-03	75	98	3	EFO_0003060
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	SLC44A2 ZFPM2	2.20e-03	21	98	2	EFO_0004286, EFO_0004792
Disease	disease	NLGN1 SLC14A2	2.20e-03	21	98	2	EFO_0000408
Disease	Lung diseases	TERT PRKDC AFF4	2.26e-03	78	98	3	C0024115
Disease	venous thromboembolism, tissue plasminogen activator measurement	SLC44A2 ZFPM2	2.64e-03	23	98	2	EFO_0004286, EFO_0004791
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR1 MTM1	2.87e-03	24	98	2	DOID:10595 (implicated_via_orthology)
Disease	lung squamous cell carcinoma (is_implicated_in)	TERT CLPTM1L	2.87e-03	24	98	2	DOID:3907 (is_implicated_in)
Disease	Periodontal Pocket	ORC2 TENM3	3.12e-03	25	98	2	EFO_1001393

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALLHWALHVYLGQEM	EXOC3L1	336	Q86VI1
QHLWYREQPILFLMD	EPG5	1156	Q9HCE0
FFWMLAQALVLAHQL	ADGRF3	856	Q8IZF5
WHTVMLYRDGLNGLL	EGFLAM	471	Q63HQ2
LLIWYGVDVMARDAH	AGAP11	506	Q8TF27
MGILFTRIWRLFNHQ	ARL5A	1	Q9Y689
TLVIYVARLFWHMDQ	APOBEC1	111	P41238
MGVFLREHLNYWYSL	ABCG1	481	P45844
RLQFYMFGWTHVTLL	CDS2	191	O95674
WMHYDGLRNVNLILL	C14orf28	276	Q4W4Y0
VIHFLAWFLENMAVL	ABCA13	3611	Q86UQ4
FAWTLVESLHVYRML	CELSR1	2546	Q9NYQ6
MTDLVRYTRQGLHWL	AFF4	1141	Q9UHB7
MLFVFIALGRWLEHI	ATP7A	786	Q04656
GTHWLEYIRMLLAGA	MTMR1	406	Q13613
VHYLLTLWQRMVASV	RANBP17	376	Q9H2T7
LTGARQYWLEGMLRH	KIAA0895L	266	Q68EN5
ILINIDYMLKALWHG	ANKAR	146	Q7Z5J8
VVNLMLAVGWYTAVH	FAR2	281	Q96K12
RLLTHWEQMDYGLQF	ORMDL2	81	Q53FV1
FVLWGCLHVYQRMID	PNPLA6	551	Q8IY17
NAIRIGMYVLHLESW	HS3ST2	246	Q9Y278
ELAKMFLNRINYWHL	KAT2B	246	Q92831
LLQGVFRVYHCNWLM	ITPR1	1521	Q14643
FTMLRAQYWFVAVPH	ATP12A	996	P54707
GIWYRSERNLQAHLM	ZFPM2	256	Q8WW38
VQEQMGCLLHYRIYW	IL12RB2	546	Q99665
DQYMLWFLLRHVTQR	DCAF8L2	576	P0C7V8
AHLVLSFLTMGYVWQ	IDO2	96	Q6ZQW0
RDAALMVAYTWLHAL	GPR26	121	Q8NDV2
WHYIERDLAMFNINI	PCNX2	1566	A6NKB5
HYGISFLRLQMWVEE	PCYOX1L	136	Q8NBM8
MNRELLWHGFAEFLI	PEX2	191	P28328
MTGLYELVWRVLHAL	NUS1	1	Q96E22
SMVLGYWDIRGLAHA	GSTM3	6	P21266
LVMVALQHFAGRWYL	ATP9A	316	O75110
LNLLHSYMNVTWIRI	OTUD7A	431	Q8TE49
YVWRAVMACLVHRGL	NLGN1	11	Q8N2Q7
ILMGSRHYSNAIDIW	NLK	311	Q9UBE8
QMAITIWVIGFFHAL	OR12D2	141	P58182
LIWIDHRLQTPMYFF	OR6M1	46	Q8NGM8
RYTVLMNVHFWGLLI	OR7G1	131	Q8NGA0
RYVGDMLAWLHQATA	COG6	306	Q9Y2V7
IWVMAISQHQFYLDR	FRMD4B	346	Q9Y2L6
NYIVRLGHLVSWMGE	ETFDH	171	Q16134
LQLMILQVLHLYWGY	CERS3	306	Q8IU89
GWMQLVILIYHISGA	CASD1	436	Q96PB1
GWIIRYLHANGASMF	MT-CYB	76	P00156
LHMYQLEGLNWLRFS	CHD3	736	Q12873
QELLGHAWMNYTAIL	GIMD1	131	P0DJR0
EIALLHRYQSQMLGW	CALHM4	176	Q5JW98
HRYQSQMLGWILITL	CALHM4	181	Q5JW98
AWVYYHMGRLSDVQI	IFIT2	101	P09913
GNRAVMALVYIWLHS	GPR161	141	Q8N6U8
YWESLLQQLRAHMAR	CACTIN	436	Q8WUQ7
RVYLHLRQTWLAFMI	SLC44A2	306	Q8IWA5
WAPRIIMILYHLYGA	GPR139	241	Q6DWJ6
TFAWLFVQGLHLYRM	CELSR3	2616	Q9NYQ7
RRWFYLHLGCMMLIN	FAM237B	6	A0A1B0GVD1
YRVLLGHTLILMFIW	SLC22A15	301	Q8IZD6
QAWLAYMNRAYHAIL	FOCAD	891	Q5VW36
LAWMILHSLYQARIV	FOCAD	1616	Q5VW36
IGWIIHAMEYELQIR	PHKB	876	Q93100
LERLYLQMWEHYAAG	OGT	1016	O15294
WMLQLHLGFNIVLYG	ORC2	301	Q13416
LRRAIWNYIHCMFGI	SESN1	401	Q9Y6P5
WLDLMILRYAHMVNG	ADSS1	341	Q8N142
YAFGLVQLLCHWLAM	PRLHR	311	P49683
LIAHMVLGYRYWAGI	SEL1L	291	Q9UBV2
WLGVLLQQHMYVLRR	SMG1	1966	Q96Q15
LWYLHKIGALRMQLD	ST8SIA1	331	Q92185
LAYFIAMHLLGLNWQ	TENM2	391	Q9NT68
ALGMWIPLYLHRAQV	SPNS2	331	Q8IVW8
GLYHLAVGMNNRAWF	WDR19	396	Q8NEZ3
VWYRDFMQLINHPNL	SEMA3A	701	Q14563
WRFLTYMFMHVGLEQ	RHBDL1	246	O75783
INHFWGVSSIYRMIL	ACSM1	311	Q08AH1
LGRLRFWIHMQDAVY	CLPTM1L	246	Q96KA5
AWRHNLVDLAMPYFI	CLTCL1	1586	P53675
LWLQYMAFHLQATEI	PDCD11	1621	Q14690
ASMRHLELWVNYYIR	MTM1	526	Q13496
ACLGTWVLYHNLRIM	NAA35	486	Q5VZE5
WVLYHNLRIMIQYLL	NAA35	491	Q5VZE5
IQMHSWGYLLQRAAA	REV3L	2406	O60673
LLNYMNWFIIAGVLL	SPNS3	56	Q6ZMD2
YLAQVLMWIGNHTEF	RINT1	336	Q6NUQ1
NRYIHILMIFWSFVA	SNX14	46	Q9Y5W7
RHGRSYNLVTLLQMW	RNF175	76	Q8N4F7
LFDSRHLLYQLLWNM	NF1	1246	P21359
DYMEFRLWIGLHSAV	SLC4A5	601	Q9BY07
SYFIAMHLFGLNWQL	TENM3	326	Q9P273
YVWRNIILMSLLHLG	SCD	71	O00767
MFWYRQDLGHGLRLI	TRBV10-1	51	A0A0K0K1A3
DVVRHWQDLGYMILY	PITPNM3	766	Q9BZ71
RQLYEPLVMQLIHWF	PRKDC	981	P78527
MQGWFHFLQDRYIVV	RHCG	106	Q9UBD6
IWNTFFHGRYLILLM	ATP6V0A4	441	Q9HBG4
FQSVHGWLMVLYERD	UBE3B	591	Q7Z3V4
WAAVQMRLLHELVYA	TRAPPC9	456	Q96Q05
LLLHMWVALFYSNQN	TASOR2	791	Q5VWN6
LPWVHRYLMENTFFV	TMC6	711	Q7Z403
MFWYRQDLGHGLRLI	TRBV10-2	51	A0A0K0K1G8
GMFYVITWQTHLLAI	SLC14A2	821	Q15849
WETFVALYHVLRMLQ	WDR87	2726	Q6ZQQ6
HQGRLYWSDLQAMFL	TFR2	131	Q9UP52
VLFDWMTRIGYHISL	UBXN8	216	O00124
MILVNALYFKGIWEH	SERPINB10	181	P48595
YWQMRPLFLELLGNH	TERT	386	O14746
HWLMSVYVVELLRSF	TERT	546	O14746
AYIQDHMLIASLWRV	UNC79	1001	Q9P2D8