Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	ATP8B4 GLTP OCA2 CLIC6 TMC3 ABCA9 SLC22A17 SLC39A13 SLC2A5 CALHM4 GJA9 SLC25A3 SLC8B1 ABCA6 CLIC1 SLCO2A1 SLC22A2 SLC49A4 PKD1 SLC13A5 KCNS3 GJA10 ABCD1 CTNS KCNK17 SVOP	4.76e-10	1289	99	26	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	OCA2 CLIC6 TMC3 ABCA9 SLC22A17 SLC39A13 SLC2A5 CALHM4 GJA9 SLC25A3 SLC8B1 ABCA6 CLIC1 SLCO2A1 SLC22A2 SLC49A4 PKD1 SLC13A5 KCNS3 GJA10 ABCD1 CTNS KCNK17 SVOP	2.20e-09	1180	99	24	GO:0022857
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	2.43e-05	2	99	2	GO:0003989
GeneOntologyMolecularFunction	lipid transporter activity	ATP8B4 GLTP ABCA9 ABCA6 SLCO2A1 SLC22A2 ABCD1	5.48e-05	196	99	7	GO:0005319
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	OCA2 CLIC6 TMC3 SLC39A13 CALHM4 SLC25A3 SLC8B1 CLIC1 PKD1 SLC13A5 KCNS3 CTNS KCNK17	1.47e-04	793	99	13	GO:0015075
GeneOntologyMolecularFunction	channel activity	OCA2 CLIC6 TMC3 CALHM4 GJA9 CLIC1 PKD1 KCNS3 GJA10 KCNK17	2.78e-04	525	99	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	OCA2 CLIC6 TMC3 CALHM4 GJA9 CLIC1 PKD1 KCNS3 GJA10 KCNK17	2.82e-04	526	99	10	GO:0022803
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	3.60e-04	6	99	2	GO:0016421
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	3.60e-04	6	99	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	5.03e-04	7	99	2	GO:0016885
GeneOntologyMolecularFunction	D2 dopamine receptor binding	CLIC6 DNM2	5.03e-04	7	99	2	GO:0031749
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCA9 SLC25A3 SLC8B1 ABCA6 SLCO2A1 SLC22A2 SLC13A5 ABCD1 CTNS	6.07e-04	477	99	9	GO:0022804
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	OCA2 CLIC6 SLC39A13 SLC25A3 SLC8B1 CLIC1 PKD1 SLC13A5 KCNS3 CTNS KCNK17	1.33e-03	758	99	11	GO:0015318
GeneOntologyBiologicalProcess	monoatomic ion transport	TCAF2 CD300A OCA2 CLIC6 DYSF TMC3 SLC22A17 SLC39A13 CALHM4 SLC25A3 SLC8B1 CLIC1 SLC22A2 PKD1 AHR SLC13A5 KCNS3 CTNS KCNK17 HRH3 DNM2	1.06e-06	1374	96	21	GO:0006811
GeneOntologyBiologicalProcess	monocyte activation involved in immune response	DYSF FER1L5	2.14e-05	2	96	2	GO:0002280
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	2.14e-05	2	96	2	GO:2001295
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	TCAF2 OCA2 CLIC6 DYSF TMC3 SLC39A13 CALHM4 SLC25A3 SLC8B1 CLIC1 PKD1 AHR SLC13A5 KCNS3 CTNS KCNK17	5.32e-05	1115	96	16	GO:0034220
GeneOntologyBiologicalProcess	response to forskolin	ADCY2 AHR HRH3	8.97e-05	19	96	3	GO:1904321
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	KDELR3 ATP8B4 PDE6D CD300A OCA2 DYSF SNX19 SLC39A13 SLC2A5 ZFYVE9 SNX25 SLC22A2 PKD1 CTNS FER1L5 SVOP DNM2 CXCR1	4.33e-05	1307	100	18	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	KDELR3 ATP8B4 PDE6D CD300A OCA2 DYSF SNX19 SLC39A13 SLC2A5 ZFYVE9 SNX25 SLC22A2 PKD1 CTNS FER1L5 SVOP DNM2 CXCR1	5.17e-05	1325	100	18	GO:0012506
Domain	MFS	SLC22A17 SLC2A5 SLCO2A1 SLC22A2 SLC49A4 SVOP	2.22e-05	108	98	6	PS50850
Domain	AcCoA_COase_cen	ACACA ACACB	2.73e-05	2	98	2	IPR013537
Domain	ACC_central	ACACA ACACB	2.73e-05	2	98	2	PF08326
Domain	MFS_sugar_transport-like	SLC22A17 SLC2A5 SLC22A2 SVOP	3.69e-05	36	98	4	IPR005828
Domain	Sugar_tr	SLC22A17 SLC2A5 SLC22A2 SVOP	3.69e-05	36	98	4	PF00083
Domain	MFS_dom	SLC22A17 SLC2A5 SLCO2A1 SLC22A2 SLC49A4 SVOP	7.47e-05	134	98	6	IPR020846
Domain	FerA	DYSF FER1L5	8.15e-05	3	98	2	SM01200
Domain	Ferlin_A-domain	DYSF FER1L5	8.15e-05	3	98	2	IPR012560
Domain	FerA	DYSF FER1L5	8.15e-05	3	98	2	PF08165
Domain	DysFC	DYSF FER1L5	1.62e-04	4	98	2	SM00694
Domain	DysFN	DYSF FER1L5	1.62e-04	4	98	2	SM00693
Domain	PXA	SNX19 SNX25	1.62e-04	4	98	2	SM00313
Domain	Sorting_nexin_C	SNX19 SNX25	1.62e-04	4	98	2	IPR013937
Domain	COA_CT_N	ACACA ACACB	1.62e-04	4	98	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	1.62e-04	4	98	2	IPR011763
Domain	Carboxyl_trans	ACACA ACACB	1.62e-04	4	98	2	PF01039
Domain	PXA	SNX19 SNX25	1.62e-04	4	98	2	PS51207
Domain	Phox_assoc	SNX19 SNX25	1.62e-04	4	98	2	IPR003114
Domain	PXA	SNX19 SNX25	1.62e-04	4	98	2	PF02194
Domain	Peroxin/Ferlin	DYSF FER1L5	1.62e-04	4	98	2	IPR006614
Domain	Nexin_C	SNX19 SNX25	1.62e-04	4	98	2	PF08628
Domain	COA_CT_CTER	ACACA ACACB	1.62e-04	4	98	2	PS50989
Domain	Carboxyl_trans	ACACA ACACB	1.62e-04	4	98	2	IPR000022
Domain	COA_CT_NTER	ACACA ACACB	1.62e-04	4	98	2	PS50980
Domain	SUGAR_TRANSPORT_1	SLC22A17 SLC2A5 SLC22A2	2.62e-04	24	98	3	PS00216
Domain	FerI	DYSF FER1L5	2.70e-04	5	98	2	SM01202
Domain	FerB	DYSF FER1L5	2.70e-04	5	98	2	SM01201
Domain	Ferlin_B-domain	DYSF FER1L5	2.70e-04	5	98	2	IPR012561
Domain	Biotin_BS	ACACA ACACB	2.70e-04	5	98	2	IPR001882
Domain	Ferlin_C	DYSF FER1L5	2.70e-04	5	98	2	PF16165
Domain	Ferlin_C	DYSF FER1L5	2.70e-04	5	98	2	IPR032362
Domain	Biotin_carb_C	ACACA ACACB	2.70e-04	5	98	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	2.70e-04	5	98	2	PF02785
Domain	FerIin_dom	DYSF FER1L5	2.70e-04	5	98	2	IPR012968
Domain	Biotin_carboxylation_dom	ACACA ACACB	2.70e-04	5	98	2	IPR011764
Domain	FerI	DYSF FER1L5	2.70e-04	5	98	2	PF08151
Domain	FerB	DYSF FER1L5	2.70e-04	5	98	2	PF08150
Domain	CPSASE_1	ACACA ACACB	2.70e-04	5	98	2	PS00866
Domain	Biotin_COase_C	ACACA ACACB	2.70e-04	5	98	2	IPR005482
Domain	BIOTIN	ACACA ACACB	2.70e-04	5	98	2	PS00188
Domain	BC	ACACA ACACB	2.70e-04	5	98	2	PS50979
Domain	CLIC	CLIC6 CLIC1	4.03e-04	6	98	2	IPR002946
Domain	CPSASE_2	ACACA ACACB	4.03e-04	6	98	2	PS00867
Domain	Rudment_hybrid_motif	ACACA ACACB	4.03e-04	6	98	2	IPR011054
Domain	ARM-type_fold	RALGAPA1 TEX10 RALGAPA2 TRRAP WDFY4 NCAPD2 NUP188 HEATR5B	4.13e-04	339	98	8	IPR016024
Domain	CPSase_L_D2	ACACA ACACB	5.63e-04	7	98	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	5.63e-04	7	98	2	IPR005479
Domain	BC-like_N	ACACA ACACB	5.63e-04	7	98	2	IPR005481
Domain	Biotin_carb_N	ACACA ACACB	5.63e-04	7	98	2	PF00289
Domain	Sugar_transporter_CS	SLC22A17 SLC2A5 SLC22A2	6.22e-04	32	98	3	IPR005829
Domain	Biotin_lipoyl	ACACA ACACB	9.58e-04	9	98	2	PF00364
Domain	Orgcat_transp/SVOP	SLC22A2 SVOP	9.58e-04	9	98	2	IPR004749
Domain	Rap_GAP	RALGAPA1 RALGAPA2	1.19e-03	10	98	2	PF02145
Domain	Biotin_lipoyl	ACACA ACACB	1.19e-03	10	98	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACA ACACB	1.19e-03	10	98	2	PS50968
Domain	Rap_GAP_dom	RALGAPA1 RALGAPA2	1.45e-03	11	98	2	IPR000331
Domain	RAPGAP	RALGAPA1 RALGAPA2	1.45e-03	11	98	2	PS50085
Domain	Spy1	SPDYE21 SPDYE5	1.45e-03	11	98	2	PF11357
Domain	Speedy	SPDYE21 SPDYE5	1.45e-03	11	98	2	IPR020984
Domain	ABC_A	ABCA9 ABCA6	1.74e-03	12	98	2	IPR026082
Domain	Single_hybrid_motif	ACACA ACACB	1.74e-03	12	98	2	IPR011053
Domain	ABC_tran	ABCA9 ABCA6 ABCD1	2.04e-03	48	98	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA9 ABCA6 ABCD1	2.04e-03	48	98	3	PS50893
Domain	-	ACACA ACACB	2.05e-03	13	98	2	3.40.50.20
Domain	ABC_TRANSPORTER_1	ABCA9 ABCA6 ABCD1	2.17e-03	49	98	3	PS00211
Domain	ABC_transporter-like	ABCA9 ABCA6 ABCD1	2.30e-03	50	98	3	IPR003439
Domain	ATP-grasp	ACACA ACACB	2.38e-03	14	98	2	IPR011761
Domain	PreATP-grasp_dom	ACACA ACACB	2.38e-03	14	98	2	IPR016185
Domain	ATP_GRASP	ACACA ACACB	2.38e-03	14	98	2	PS50975
Domain	-	ACACA ACACB	2.74e-03	15	98	2	3.30.1490.20
Domain	ARM-like	SETX TEX10 TRRAP WDFY4 NCAPD2 HEATR5B	3.00e-03	270	98	6	IPR011989
Domain	SUGAR_TRANSPORT_2	SLC2A5 SLC22A2	3.52e-03	17	98	2	PS00217
Domain	ATP_grasp_subdomain_1	ACACA ACACB	3.95e-03	18	98	2	IPR013815
Domain	-	ACACA ACACB	3.95e-03	18	98	2	3.30.470.20
Domain	CONNEXINS_1	GJA9 GJA10	4.40e-03	19	98	2	PS00407
Domain	CONNEXINS_2	GJA9 GJA10	4.87e-03	20	98	2	PS00408
Domain	Connexin	GJA9 GJA10	4.87e-03	20	98	2	IPR000500
Domain	Connexin_CCC	GJA9 GJA10	4.87e-03	20	98	2	IPR019570
Domain	Connexin_N	GJA9 GJA10	4.87e-03	20	98	2	IPR013092
Domain	Connexin	GJA9 GJA10	4.87e-03	20	98	2	PF00029
Domain	Connexin_CCC	GJA9 GJA10	4.87e-03	20	98	2	SM01089
Domain	Connexin_CS	GJA9 GJA10	4.87e-03	20	98	2	IPR017990
Domain	CNX	GJA9 GJA10	4.87e-03	20	98	2	SM00037
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA9 ABCA6 ABCD1	8.60e-05	17	73	3	MM14552
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	LMF1 ATP8B4 GLTP ADCY2 ABCA9 SLC22A17 SLC8B1 ABCA6 SLCO2A1 SLC22A2 SLC13A5 ABCD1 CTNS	9.09e-05	736	73	13	M27287
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCA9 ABCA6 ABCD1	1.03e-04	18	73	3	M524
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	LMF1 ATP8B4 GLTP ABCA9 SLC22A17 SLC8B1 ABCA6 SLCO2A1 SLC22A2 SLC13A5 ABCD1 CTNS	1.79e-04	681	73	12	MM14985
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	8.52e-06	2	102	2	25282359
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	8.52e-06	2	102	2	27693630
Pubmed	Linkage and association analysis of spectrophotometrically quantified hair color in Australian adolescents: the effect of OCA2 and HERC2.	OCA2 HERC2	8.52e-06	2	102	2	18528436
Pubmed	Effects on sperm morphology by alleles at the pink-eyed dilution locus in mice.	OCA2 HERC2	8.52e-06	2	102	2	863229
Pubmed	Associations of OCA2-HERC2 SNPs and haplotypes with human pigmentation characteristics in the Brazilian population.	OCA2 HERC2	8.52e-06	2	102	2	28081795
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	8.52e-06	2	102	2	32215608
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	8.52e-06	2	102	2	29772612
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	8.52e-06	2	102	2	29976587
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	8.52e-06	2	102	2	24944901
Pubmed	Molecular characterization of radiation- and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 mice.	OCA2 HERC2	8.52e-06	2	102	2	10441737
Pubmed	A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color.	OCA2 HERC2	8.52e-06	2	102	2	18252222
Pubmed	Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.	OCA2 HERC2	8.52e-06	2	102	2	18252221
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	8.52e-06	2	102	2	15749055
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	8.52e-06	2	102	2	20139635
Pubmed	Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.	OCA2 HERC2	8.52e-06	2	102	2	1495987
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	8.52e-06	2	102	2	28081256
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	8.52e-06	2	102	2	26976583
Pubmed	Gender is a major factor explaining discrepancies in eye colour prediction based on HERC2/OCA2 genotype and the IrisPlex model.	OCA2 HERC2	8.52e-06	2	102	2	23601698
Pubmed	Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene.	OCA2 HERC2	8.52e-06	2	102	2	7604002
Pubmed	The effects of mutant p-alleles on the reproductive system in mice.	OCA2 HERC2	8.52e-06	2	102	2	4435358
Pubmed	Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.	OCA2 HERC2	8.52e-06	2	102	2	34795370
Pubmed	A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice.	OCA2 HERC2	8.52e-06	2	102	2	9689098
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	8.52e-06	2	102	2	29433631
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	8.52e-06	2	102	2	36076520
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	8.52e-06	2	102	2	25001074
Pubmed	Variants at the OCA2/HERC2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs.	OCA2 HERC2	8.52e-06	2	102	2	28456133
Pubmed	Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown eye color in the Japanese population.	OCA2 HERC2	8.52e-06	2	102	2	19472299
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	8.52e-06	2	102	2	10677481
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	8.52e-06	2	102	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	8.52e-06	2	102	2	30244972
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	8.52e-06	2	102	2	24338821
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	2.55e-05	3	102	2	34668531
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	2.55e-05	3	102	2	30018077
Pubmed	Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.	RALGAPA1 RALGAPA2	2.55e-05	3	102	2	19520869
Pubmed	Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse.	OCA2 HERC2	2.55e-05	3	102	2	5565073
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	2.55e-05	3	102	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	2.55e-05	3	102	2	18031993
Pubmed	Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.	OCA2 HERC2	2.55e-05	3	102	2	23118974
Pubmed	Interactions between HERC2, OCA2 and MC1R may influence human pigmentation phenotype.	OCA2 HERC2	2.55e-05	3	102	2	19208107
Pubmed	Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility.	FER1L4 FER1L5	2.55e-05	3	102	2	36696506
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	2.55e-05	3	102	2	28877461
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	2.55e-05	3	102	2	20457939
Pubmed	Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response.	TBK1 AHR	2.55e-05	3	102	2	38043800
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	2.55e-05	3	102	2	36417534
Pubmed	Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.	ACACA ACACB	2.55e-05	3	102	2	17521700
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	2.55e-05	3	102	2	18455495
Pubmed	Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.	ACACA ACACB	2.55e-05	3	102	2	31990961
Pubmed	The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.	ACACA ACACB	2.55e-05	3	102	2	27381369
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACA ACACB	2.55e-05	3	102	2	17210641
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	2.55e-05	3	102	2	28768177
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACA ACACB SLC2A5	3.62e-05	22	102	3	20965718
Pubmed	Human eye colour and HERC2, OCA2 and MATP.	OCA2 HERC2	5.09e-05	4	102	2	20457063
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACA ACACB	5.09e-05	4	102	2	38447582
Pubmed	Expression of connexin genes in the human retina.	GJA9 GJA10	5.09e-05	4	102	2	20979653
Pubmed	Genetic analysis of three important genes in pigmentation and melanoma susceptibility: CDKN2A, MC1R and HERC2/OCA2.	OCA2 HERC2	5.09e-05	4	102	2	20629734
Pubmed	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.	ACACA ACACB	5.09e-05	4	102	2	24185692
Pubmed	Crystal structure of Spot 14, a modulator of fatty acid synthesis.	ACACA ACACB	5.09e-05	4	102	2	20952656
Pubmed	An integrated deletion and physical map encompassing l71Rl, a chromosome 7 locus required for peri-implantation survival in the mouse.	OCA2 HERC2	8.47e-05	5	102	2	10903848
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	ACACA ACACB	8.47e-05	5	102	2	37163372
Pubmed	Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes.	ABCA9 ABCA6	8.47e-05	5	102	2	12532264
Pubmed	Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.	ACACA ACACB	8.47e-05	5	102	2	32694673
Pubmed	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.	ACACA ACACB	8.47e-05	5	102	2	16794074
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	FLT1 ACACA ACACB TEX10 DYSF TRRAP NCAPD2 USP39	1.11e-04	497	102	8	36774506
Pubmed	Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.	GJA9 GJA10	1.27e-04	6	102	2	12881038
Pubmed	Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse.	OCA2 HERC2	1.27e-04	6	102	2	8095339
Pubmed	Genetic regulation of coumarin hydroxylase activity in mice. Evidence for single locus control on chromosome.	OCA2 AHR	1.27e-04	6	102	2	447675
Pubmed	Defining the membrane proteome of NK cells.	GDPD1 SLC25A3 CLIC1 ALDH16A1 ALG5 NCAPD2 PEX16 CHST12 ABCD1 NUP188 HERC2 HEATR5B	1.63e-04	1168	102	12	19946888
Pubmed	Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.	DYSF DNM2	1.77e-04	7	102	2	29130937
Pubmed	Polycystic Kidney Disease, Autosomal Dominant	ALG5 PKD1	1.77e-04	7	102	2	20301424
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TEX10 TRRAP WDR43 SLC25A3 CLIC1 TBK1 CCT8 NUP188 USP39 HERC2 HEATR5B	2.12e-04	1024	102	11	24711643
Pubmed	Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.	SLC39A13 WDR43 SLCO2A1 ALG5	2.20e-04	100	102	4	26073538
Pubmed	The peroxisomal receptor Pex19p forms a helical mPTS recognition domain.	PEX16 ABCD1	2.36e-04	8	102	2	20531392
Pubmed	A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.	OCA2 HERC2	2.36e-04	8	102	2	18483556
Pubmed	The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.	ACACA ACACB	2.36e-04	8	102	2	36001969
Pubmed	Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.	RHBDD1 PKD1	2.36e-04	8	102	2	22795130
Pubmed	Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.	ACACA NCAPD2 HERC2	2.41e-04	41	102	3	19343720
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SETX ACACA ALDH16A1 TBK1 PKD1 AHR CCT8 NUP188 USP39	3.22e-04	736	102	9	29676528
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ACACA SLC25A3 PHKB NCAPD2 HERC2	3.32e-04	202	102	5	33005030
Pubmed	The human ATP-binding cassette (ABC) transporter superfamily.	ABCA9 ABCA6	3.77e-04	10	102	2	11435397
Pubmed	SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.	ACACA ACACB	3.77e-04	10	102	2	19720090
Pubmed	Genetic determinants of hair, eye and skin pigmentation in Europeans.	OCA2 HERC2	3.77e-04	10	102	2	17952075
Pubmed	A microsatellite map of the pink-eyed dilution (p) deletion complex in mouse chromosome 7.	OCA2 HERC2	3.77e-04	10	102	2	9060416
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SLC2A5 SLC25A3 SLC22A2 AHR SVOP	4.14e-04	212	102	5	19521566
Pubmed	PEX14 is required for microtubule-based peroxisome motility in human cells.	PEX16 CCT8 DNM2	5.45e-04	54	102	3	21525035
Pubmed	HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	ACACA ACACB	5.51e-04	12	102	2	21344388
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	ACACA ACACB	5.51e-04	12	102	2	21436046
Pubmed	Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.	OCA2 HERC2	6.50e-04	13	102	2	8601493
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ACACA TEX10 TRRAP WDR43 NCAPD2 NUP188 HERC2 DNM2	6.91e-04	653	102	8	22586326
Pubmed	A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells.	SLC39A13 SLC2A5 AIG1	7.42e-04	60	102	3	26272612
Pubmed	κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation.	RALGAPA1 RALGAPA2	7.57e-04	14	102	2	25220458
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	TEX10 PHKB ZFYVE9 HERC2	7.67e-04	139	102	4	25476789
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	CLIC6 DYSF SLC2A5 SLC25A3 CLIC1 SLC22A2 PKD1 CCT8 CTNS DNM2	8.16e-04	1016	102	10	19056867
Pubmed	Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.	OCA2 HERC2	8.72e-04	15	102	2	23548203
Pubmed	Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.	SLCO2A1 SLC22A2	9.95e-04	16	102	2	35307651
Pubmed	PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.	PEX16 ABCD1	9.95e-04	16	102	2	10704444
Pubmed	Hdac3 regulates lymphovenous and lymphatic valve formation.	FLT1 ITGA9	9.95e-04	16	102	2	29035278
Pubmed	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	PEX16 ABCD1	9.95e-04	16	102	2	14561759
Pubmed	Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.	DYSF DNM2	9.95e-04	16	102	2	32994313
Pubmed	Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.	OCA2 HERC2	9.95e-04	16	102	2	8601494
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ADCY2 SLC22A17 SLC39A13 PKD1 AIG1 PEX16 HERC2 SVOP	1.05e-03	697	102	8	28298427
Cytoband	12q24.11	GLTP ACACB SVOP	5.53e-05	33	102	3	12q24.11
GeneFamily	Ferlin family	DYSF FER1L4 FER1L5	1.15e-06	6	71	3	828
GeneFamily	Solute carriers	SLC22A17 SLC39A13 SLC2A5 SLC35F4 SLC25A3 SLC8B1 SLCO2A1 SLC22A2 SLC49A4 SLC13A5	3.11e-06	395	71	10	752
GeneFamily	Chloride intracellular channels	CLIC6 CLIC1	2.26e-04	6	71	2	307
GeneFamily	ATP binding cassette subfamily A	ABCA9 ABCA6	1.34e-03	14	71	2	805
GeneFamily	AAA ATPases\|Peroxins	PEX11G PEX16	1.76e-03	16	71	2	957
GeneFamily	Gap junction proteins	GJA9 GJA10	3.34e-03	22	71	2	314
Coexpression	HALLMARK_BILE_ACID_METABOLISM	PEX11G CYP8B1 ABCA9 ABCA6 PEX16 ABCD1	4.57e-06	112	100	6	M5948
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B4 CD300A WDFY4 SLC8B1 NCAPD2 LY9	2.24e-06	165	102	6	1dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP8B4 CYP2S1 ABCA9 ABCA6 AHR KCNK17	4.19e-06	184	102	6	1c56378b3888c46258d446b47de4d6282fe74b0d
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ATP8B4 CYP2S1 ABCA9 ABCA6 AHR KCNK17	4.19e-06	184	102	6	a45980306c4e697a2703bed72a7b48fb23d942f4
ToppCell	(7)_DC_1\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CYP2S1 DYSF WDFY4 ADGB SLCO2A1 AHR	4.74e-06	188	102	6	832887afa4a54ed80906bc02176d646529c13398
ToppCell	3'_v3-Lung-Myeloid_Dendritic-DC2\|Lung / Manually curated celltypes from each tissue	ATP8B4 CD300A CYP2S1 ADGB ABCA6 KCNK17	5.04e-06	190	102	6	468525c05e38158a3b8a445882b2d63dfb1d2c63
ToppCell	Non-neuronal-Postmitotic-Mural-Mural\|World / Primary Cells by Cluster	FLT1 CD300A DYSF ABCA9 GGT5 CLIC1	6.38e-06	198	102	6	9fc1035ea447a4551a66944c869c4671e17cec61
ToppCell	Non-neuronal-Postmitotic-Mural\|World / Primary Cells by Cluster	FLT1 CD300A DYSF ABCA9 GGT5 CLIC1	6.38e-06	198	102	6	dd38840a96171f58da243daa22b013e15a81db4a
ToppCell	Non-neuronal-Postmitotic-Mural-Mural-18\|World / Primary Cells by Cluster	FLT1 CD300A DYSF ABCA9 GGT5 CLIC1	6.38e-06	198	102	6	21efb7bcd24f24d20791b34e75d6f9d46a129481
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KDELR3 ABCA9 GGT5 SLC22A2 KCNK17 PRODH	6.57e-06	199	102	6	dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KDELR3 ABCA9 GGT5 SLC22A2 KCNK17 PRODH	6.57e-06	199	102	6	c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B4 CYP8B1 CYP2S1 WDFY4 ADGB	1.77e-05	140	102	5	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DYSF TMC3 GGT5 FAM157A CXCR1	1.90e-05	142	102	5	191a13bba143ecdfc2bfd797c3ac191481388298
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DYSF TMC3 GGT5 FAM157A CXCR1	1.97e-05	143	102	5	b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DYSF PIGZ CALHM4 SLCO2A1	2.89e-05	155	102	5	5d157478669b609e1f0f0a75afd0112571fc2c46
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP8B4 SLC2A5 GGT5 CTNS TMEM143	3.37e-05	160	102	5	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA9 PIGZ ABCA9 ZFYVE9 SNX25	3.37e-05	160	102	5	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B4 CYP8B1 CD300A WDFY4 LY9	3.47e-05	161	102	5	16f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B4 CYP8B1 CD300A WDFY4 LY9	3.47e-05	161	102	5	f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B4 CYP8B1 CD300A WDFY4 LY9	3.47e-05	161	102	5	58a32a1033f379579697bda1bbf047a088e4a34f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B4 CD300A CYP2S1 ABCA9 LY9	3.68e-05	163	102	5	8028636632c168dc50731d0ebecaf88a70daf81d
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLTP CD300A TMC3 ABCA9 ADGB	4.02e-05	166	102	5	03a47b8687f54955e84df1edcb230db332c4ca8f
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDPD1 WDFY4 PIGZ ABCA9 ADGB	4.25e-05	168	102	5	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TCAF2 FLT1 ITGA9 DYSF SLCO2A1	4.76e-05	172	102	5	c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCell	P15-Endothelial-capillary_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 GLTP CLIC1 SLCO2A1 AHR	5.90e-05	180	102	5	63e7ec20a93452a02bf904acebdbe3d0d9ae8894
ToppCell	P15-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GLTP CLIC1 SLCO2A1 AHR DNAH8	5.90e-05	180	102	5	410ea13a9c00cf54b4d47c72404dfe893c086d87
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMF1 GGT5 CDAN1 DNAH8 TEDC1	6.06e-05	181	102	5	e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMF1 GGT5 CDAN1 DNAH8 TEDC1	6.06e-05	181	102	5	d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell	P15-Endothelial\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 GLTP CLIC1 SLCO2A1 AHR	6.38e-05	183	102	5	ef82ce4658a775ee2ef0e564d2d1042898a1bd75
ToppCell	P03-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 CLIC1 SLCO2A1 AHR DNAH8	7.07e-05	187	102	5	cb74b8014a9046cbcdf0d2933c9f539a3b08d068
ToppCell	P03-Endothelial-capillary_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 CLIC1 SLCO2A1 AHR DNAH8	7.25e-05	188	102	5	ede354ca550840d8f0c8dac22d8ce1f1d325886a
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLT1 ITGA9 RALGAPA2 SLCO2A1 CSMD1	7.43e-05	189	102	5	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TCAF2 FLT1 ITGA9 DYSF SLCO2A1	7.62e-05	190	102	5	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TCAF2 FLT1 ITGA9 RALGAPA2 SLCO2A1	8.00e-05	192	102	5	1ee4783051ec94ea94600f040edcb385fc4289f1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TCAF2 FLT1 ITGA9 DYSF SLCO2A1	8.00e-05	192	102	5	25cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 CLIC1 SLCO2A1 AHR DNAH8	8.20e-05	193	102	5	b7c0b4dbbe11f86cff6371d3d12a6b772b938d78
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 CLIC1 SLCO2A1 AHR DNAH8	8.20e-05	193	102	5	e44d777f65b907f299cefd73296805ac4c92d383
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TCAF2 FLT1 ITGA9 DYSF SLCO2A1	8.20e-05	193	102	5	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	COVID-19-Myeloid-DC2\|Myeloid / Condition, Lineage and Cell class	ATP8B4 CYP2S1 ABCA6 AHR KCNK17	8.20e-05	193	102	5	5f3f6db3d3de887d004662d229f42549601efa81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TCAF2 FLT1 ITGA9 DYSF SLCO2A1	8.40e-05	194	102	5	cf9cf115dbbb9997f7c303ae07f42f3d80ff9a21
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TCAF2 FLT1 ITGA9 DYSF SLCO2A1	8.40e-05	194	102	5	ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLT1 CD300A CYP2S1 AHR KCNK17	8.61e-05	195	102	5	9c6bed8414633813e1655bbeaab682fb296958a9
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	TCAF2 FLT1 ITGA9 DYSF SLCO2A1	8.82e-05	196	102	5	ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ITGA9 RALGAPA2 DYSF SLCO2A1	8.82e-05	196	102	5	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ITGA9 RALGAPA2 DYSF SLCO2A1	8.82e-05	196	102	5	d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCell	COVID-19-lung-Capillary_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TCAF2 FLT1 RALGAPA2 DYSF SLCO2A1	8.82e-05	196	102	5	ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCell	COVID-19-lung-Capillary_1\|lung / Disease (COVID-19 only), tissue and cell type	TCAF2 FLT1 RALGAPA2 DYSF SLCO2A1	9.03e-05	197	102	5	7e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell	Biopsy_IPF-Immune-pDCs\|Biopsy_IPF / Sample group, Lineage and Cell type	CD300A WDFY4 CTNS LY9 KCNK17	9.25e-05	198	102	5	aa8943e6796f619406056cf763b751fe9a9a3e0c
ToppCell	COVID-19-lung-Capillary_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLT1 RALGAPA2 DYSF SLCO2A1 CSMD1	9.25e-05	198	102	5	45419f2804b4be79bae6632e71c54e1af482d115
ToppCell	Biopsy_Control_(H.)-Immune-cDCs\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	ATP8B4 CD300A CYP2S1 WDFY4 ABCA6	9.69e-05	200	102	5	cc6ba99a877a13c63dc1d6f81538065a7f29b8f6
ToppCell	LPS_only-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CYP2S1 WDFY4 ADGB SLC8B1	1.28e-04	112	102	4	9801227fe5a6f5ae1b6c5a9e7fa7f35c4c52efe1
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	DYSF FER1L4 FER1L5	1.12e-06	7	95	3	DOID:11724 (implicated_via_orthology)
Disease	SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 1	OCA2 HERC2	1.03e-05	2	95	2	227220
Disease	SKIN/HAIR/EYE PIGMENTATION 1, BLUE/NONBLUE EYES	OCA2 HERC2	1.03e-05	2	95	2	cv:C1856895
Disease	suntan, skin pigmentation	OCA2 HERC2	6.13e-05	4	95	2	EFO_0003784, EFO_0004279
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB	1.02e-04	5	95	2	DOID:0080000 (implicated_via_orthology)
Disease	cuneus cortex volume measurement	GJA9 AHR GJA10	1.36e-04	31	95	3	EFO_0010301
Disease	gene methylation measurement	CDAN1 ABCA6	1.53e-04	6	95	2	EFO_0006959
Disease	pulse pressure measurement, anxiety	GJA9 GJA10	2.13e-04	7	95	2	EFO_0005230, EFO_0005763
Disease	valine measurement	ACACB BCAT2 PRODH	2.93e-04	40	95	3	EFO_0009792
Disease	hair colour measurement, eye colour measurement, skin pigmentation measurement	OCA2 HERC2	4.54e-04	10	95	2	EFO_0007009, EFO_0007822, EFO_0009764
Disease	total lipids in small LDL	BCAT2 ABCA6 SLC22A2	4.73e-04	47	95	3	EFO_0022168
Disease	pigmentation disease (is_implicated_in)	OCA2 HERC2	5.54e-04	11	95	2	DOID:10123 (is_implicated_in)
Disease	illegal drug consumption	ITGA9 CSMD1	7.82e-04	13	95	2	EFO_0005431
Disease	Connective Tissue Diseases	SLC39A13 PKD1	7.82e-04	13	95	2	C0009782
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACACA ACACB CYP8B1	1.22e-03	65	95	3	DOID:0080208 (biomarker_via_orthology)
Disease	squamous cell carcinoma	OCA2 AHR HERC2	1.33e-03	67	95	3	EFO_0000707
Disease	extrahepatic cholestasis (biomarker_via_orthology)	CYP8B1 SLC22A2	1.35e-03	17	95	2	DOID:13619 (biomarker_via_orthology)
Disease	apolipoprotein B measurement	ACACB BCAT2 ABCA9 ABCA6 FER1L4 SLC22A2 KCNK17 DNM2	1.36e-03	663	95	8	EFO_0004615
Disease	susceptibility to mononucleosis measurement	ADCY2 PRDM11 DNAH8	1.45e-03	69	95	3	EFO_0008403
Disease	skin pigmentation	ATP8B4 OCA2 HERC2	1.45e-03	69	95	3	EFO_0003784
Disease	skin sensitivity to sun	OCA2 HERC2	1.69e-03	19	95	2	EFO_0004795
Disease	leucine measurement	RHBDD1 BCAT2 PRODH	1.71e-03	73	95	3	EFO_0009770
Disease	disease	BCAT2 SLC22A2	2.07e-03	21	95	2	EFO_0000408
Disease	metabolite measurement	ATP8B4 WDFY4 SLC22A2 AHR SLC13A5 CSMD1 PRODH	2.24e-03	560	95	7	EFO_0004725
Disease	Malignant neoplasm of breast	FLT1 OCA2 ITGA9 DYSF SLC2A5 PHKB CLIC1 AHR HERC2 PRODH	2.41e-03	1074	95	10	C0006142
Disease	airway responsiveness measurement	WDFY4 CSMD1	2.70e-03	24	95	2	EFO_0006897
Disease	heart failure	LMF1 DYSF PKD1 HEATR5B	3.05e-03	185	95	4	EFO_0003144
Disease	eye color	OCA2 HERC2 CSMD1	3.10e-03	90	95	3	EFO_0003949

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGMIVFRLLTKNNRW	AHR	346	P35869
KLISLRDWMLAVLAF	AIG1	81	Q9NVV5
MTAWRRFQSLLLLLG	CSMD1	1	Q96PZ7
RAWLSHTNKMIFRLL	CXorf58	51	Q96LI9
LGLRVARTKALWLPM	ALDH16A1	786	Q8IZ83
IKIQAMWRGTYVRLL	ADGB	911	Q8N7X0
MKRQTLLEWLFSFLL	ABCA9	26	Q8IUA7
WLQMGKDLLFIRLRY	ALG5	296	Q9Y673
VGKIWLTILFIFRML	GJA10	21	Q969M2
MKRESLLEWGLSILL	ABCA6	26	Q8N139
VMRYGSRLWKLRVLQ	ACACA	1496	Q13085
TNLIFLSGNRVLKWM	AARSD1	236	Q9BTE6
RLMNTLVLWIFGFLI	ATP8B4	271	Q8TF62
QLLLTWGMIFEKLRI	AADACL3	51	Q5VUY0
QRLFMILWLKGVIFN	CLIC6	491	Q96NY7
RRLLHMLLSLWKEDF	CDAN1	1111	Q8IWY9
LRRCVQWLKVMGLFA	OCA2	171	Q04671
GMNRVFLQRLLWLLR	ABCD1	66	P33897
MRYGSRLWKLRVLQA	ACACB	1616	O00763
VWKGLFARIIMIGTL	SLC25A3	311	Q00325
RMWALQRLRKLLTTE	HERC2	3771	O95714
WFRGRLLLAVSMQVL	FER1L4	336	A9Z1Z3
GERWRQLRKFTMLAL	CYP2S1	121	Q96SQ9
LLAFAMKRIWIHRRG	FAM157A	161	C9JC47
SHLLAMILLLGKIWR	KDELR3	11	O43731
FGMAWLALIIKLILS	KCNK17	251	Q96T54
ILRGFKLNWMNLRDA	PDE6D	11	O43924
RDLSRIWQGMLTIKA	DNAH8	2661	Q96JB1
RSQKFLIWLSDLLLM	GDPD1	246	Q8N9F7
LIWLSDLLLMRKALF	GDPD1	251	Q8N9F7
TLRFGQLRKKIWIRM	KCNS3	161	Q9BQ31
GLLFRTLMVAWIRAN	RALGAPA2	596	Q2PPJ7
IRRGWLTINNISLMK	DNM2	521	P50570
KLGTIVMLRGLLWVS	OR52R1	146	Q8NGF1
LLAVLLWKMGFFRRR	ITGA9	996	Q13797
LLMWLLKSSGIIANR	ADCY2	661	Q08462
KMLLLWRNVFPRSLK	HEATR5B	576	Q9P2D3
IGKIWLTILFIFRML	GJA9	21	P57773
AFMWLLDKRGLRITV	SLC49A4	106	Q96SL1
RLLKMRWSGLNAIQF	GLB1L	66	Q6UWU2
LGNDTAKWRMVLRIL	CXCR1	191	P25024
LILLVAGFALRSQMW	CALHM4	61	Q5JW98
QAIMSKLWLGFDLRA	GGT5	501	P36269
TLALMWLKRGLRFIQ	GLTP	91	Q9NZD2
RAVRKMLLVWVLAFL	HRH3	151	Q9Y5N1
RNTKLWIGLFLMVCL	LY9	451	Q9HBG7
VIMNWRRKSVIGLSF	CTNS	146	O60931
MAFQGLLRVRWLRLS	CHADL	176	Q6NUI6
MAAAALGQIWARKLL	BCAT2	1	O15382
LRTLLWVGAKPARLM	SLC13A5	111	Q86YT5
TWMLIFRLIQGLVSK	SLC22A2	201	O15244
MLRSEAGAWRLKQLL	SLC39A13	96	Q96H72
SFRKLMRWILILVIA	DSEL	796	Q8IZU8
RTAIEILAWGLRNMK	DYSF	1331	O75923
WLEVGRLQRLFHKML	CYP8B1	226	Q9UNU6
ELFSGMLKIRIGWII	PHKB	866	Q93100
ELFLRRLRLWMGLSK	PKD1	4131	P98161
RLRLWMGLSKVKEFR	PKD1	4136	P98161
MAGRRLNLRWALSVL	SLC8B1	1	Q6J4K2
AVLRMLLLLWFKAGL	PEX16	121	Q9Y5Y5
NAKLRRAVMTILLWA	TAS2R38	301	P59533
TNRWDLMGKELLRLR	PARS2	131	Q7L3T8
LWIIDRLGRKKTMAL	SVOP	391	Q8N4V2
VLKLIGLMYLRSWAV	TMC3	586	Q7Z5M5
ASMLWKGINLERRLG	RHBDD1	86	Q8TEB9
FLLVQRFGELMRKLW	USP39	271	Q53GS9
LALVSKDWRFLQRMI	SLC22A17	206	Q8WUG5
KMGPFLLNAVRWLAR	TCAF2	281	A6NFQ2
IKRMAIEILAWGLRN	FER1L5	1241	A0AVI2
MLAFLLTWEKLKRRG	NBPF11	816	Q86T75
RGMFKWVRRTLIALV	SNX25	696	Q9H3E2
LKLFRMRSLRWQLLS	SLC2A5	266	P22732
GKLVWMRLLSEGRVR	PRDM11	491	Q9NQV5
LMKGTHRERQLLWLE	PRODH	571	O43272
MVRRWAILTARNLGK	SETX	166	Q7Z333
LLSWIVLKDRFMGVR	SLC35F4	291	A4IF30
LLLVGASLLAWRMFQ	CD300A	191	Q9UGN4
FSQRLFMVLWLKGVT	CLIC1	26	O00299
LFRLWLVLGSVFMIL	CHST12	6	Q9NRB3
ALFGVRRMLPLIWSK	NCAPD2	671	Q15021
FAIGVQFLLMRLLAW	SLCO2A1	551	Q92959
SLLLGVARSLWMLLK	PEX11G	136	Q96HA9
VARSLWMLLKLRQRL	PEX11G	141	Q96HA9
RLLLSILGMNSWDKR	RALGAPA1	1766	Q6GYQ0
MTVELWLRLRGKGLA	TMEM143	1	Q96AN5
WLRLRGKGLAMLHVT	TMEM143	6	Q96AN5
IPLLRKRWFQLGRSM	SPDYE21	281	A0A494C086
IPLLRKRWFQLGRSM	SPDYE5	281	A6NIY4
LMGKLRFRWRQLVSS	TEDC1	171	Q86SX3
GKTIWLRNQLLEMLL	WDFY4	1586	Q6ZS81
YTRITRLKGWILEIM	TMPRSS9	721	Q7Z410
GSMKCTLLLILLRQW	NUP188	1156	Q5SRE5
SKQLNRLLGVSWRLM	TEX10	476	Q9NXF1
KMAVRVLWGGLSLLR	PIGZ	31	Q86VD9
SRKLMAVGVLLGWLL	SNX19	26	Q92543
WFKRLIALRQERLMG	RSRC1	316	Q96IZ7
LILTGIWQMRHLKSF	TMED4	206	Q7Z7H5
RWISRGRMLKRLFEL	ZMYM6	1071	O95789
RYALQVWRLMLSLGL	PTCD1	301	O75127
LFWLLLTLFIRKMKR	FLT1	771	P17948
MLVRLNSKWDLRRLC	CCT8	311	P50990
WTFRKMFTIQLALIG	TRRAP	3666	Q9Y4A5
WAKVFPIRLMLRLGA	ZFYVE9	1066	O95405
TLLLYQELMRKGIRW	TBK1	431	Q9UHD2
KMLLSAGRTIKLWVL	WDR43	181	Q15061
RWLIFRIMLGAGLIK	LMF1	211	Q96S06