Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microfilament motor activity	MYH3 MYH6 MYH7 MYH13	4.10e-06	38	57	4	GO:0000146
GeneOntologyMolecularFunction	calmodulin binding	MYH3 MYH6 MYH7 MYH13 CNN1 RYR3	4.86e-05	230	57	6	GO:0005516
GeneOntologyMolecularFunction	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	B3GNT7 B3GNT3	1.19e-04	6	57	2	GO:0008532
GeneOntologyMolecularFunction	sodium channel inhibitor activity	NEDD4L NEDD4	2.22e-04	8	57	2	GO:0019871
GeneOntologyMolecularFunction	guanylate cyclase activity	NPR2 GUCY1B2	3.55e-04	10	57	2	GO:0004383
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH3 MYH6 MYH7 MYH13	3.59e-04	118	57	4	GO:0003774
GeneOntologyMolecularFunction	actin filament binding	MYH3 MYH6 MYH7 MYH13 CNN1	4.70e-04	227	57	5	GO:0051015
GeneOntologyMolecularFunction	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	B3GNT7 B3GNT3	5.19e-04	12	57	2	GO:0008499
GeneOntologyMolecularFunction	glutamate binding	GAD1 GRIN2B	7.13e-04	14	57	2	GO:0016595
GeneOntologyMolecularFunction	beta-1,3-galactosyltransferase activity	B3GNT7 B3GNT3	8.21e-04	15	57	2	GO:0048531
GeneOntologyMolecularFunction	transition metal ion binding	CYP2E1 LMCD1 XPNPEP3 ZFHX3 TRIM77 GRIN2B CPN1 PIAS2 MTPAP PNMA3	1.80e-03	1189	57	10	GO:0046914
GeneOntologyMolecularFunction	myosin phosphatase activity	MYH3 MYH6 CTDSP1	1.85e-03	85	57	3	GO:0017018
GeneOntologyMolecularFunction	cyclase activity	NPR2 GUCY1B2	2.12e-03	24	57	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	NPR2 GUCY1B2	2.30e-03	25	57	2	GO:0016849
GeneOntologyMolecularFunction	actin binding	MYH3 MYH6 MYH7 MYH13 TBC1D21 CNN1	2.38e-03	479	57	6	GO:0003779
GeneOntologyBiologicalProcess	muscle contraction	MYH3 CACNA2D1 MYH6 MYH7 NEDD4L MYH13 MAP2K1 CNN1 RYR3	1.63e-06	400	58	9	GO:0006936
GeneOntologyBiologicalProcess	muscle system process	MYH3 CACNA2D1 MYH6 MYH7 NEDD4L MYH13 LMCD1 MAP2K1 CNN1 RYR3	2.63e-06	547	58	10	GO:0003012
GeneOntologyBiologicalProcess	muscle filament sliding	MYH3 MYH6 MYH7	9.37e-06	15	58	3	GO:0030049
GeneOntologyBiologicalProcess	actin-myosin filament sliding	MYH3 MYH6 MYH7	1.67e-05	18	58	3	GO:0033275
GeneOntologyBiologicalProcess	actin-mediated cell contraction	MYH3 CACNA2D1 MYH6 MYH7 NEDD4L	2.89e-05	127	58	5	GO:0070252
GeneOntologyBiologicalProcess	striated muscle contraction	MYH3 CACNA2D1 MYH6 MYH7 NEDD4L RYR3	3.25e-05	217	58	6	GO:0006941
GeneOntologyBiologicalProcess	actin filament-based movement	MYH3 CACNA2D1 MYH6 MYH7 NEDD4L	7.02e-05	153	58	5	GO:0030048
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	AREL1 UBA1 NEDD4L KLHL15 TRIM77 HSPBP1 OTULINL CBFB PIAS2 VCPIP1 NEDD4	9.98e-05	1009	58	11	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	AREL1 UBA1 NEDD4L KLHL15 TRIM77 HSPBP1 OTULINL CBFB PIAS2 VCPIP1 NEDD4	1.73e-04	1074	58	11	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	AREL1 UBA1 NEDD4L KLHL15 TRIM77 HSPBP1 CBFB PIAS2 VCPIP1 NEDD4	1.74e-04	893	58	10	GO:0032446
GeneOntologyBiologicalProcess	poly-N-acetyllactosamine biosynthetic process	B3GNT7 B3GNT3	2.76e-04	9	58	2	GO:0030311
GeneOntologyBiologicalProcess	poly-N-acetyllactosamine metabolic process	B3GNT7 B3GNT3	3.45e-04	10	58	2	GO:0030309
GeneOntologyBiologicalProcess	regulation protein catabolic process at postsynapse	NEDD4L NEDD4	3.45e-04	10	58	2	GO:0140252
GeneOntologyBiologicalProcess	protein ubiquitination	AREL1 UBA1 NEDD4L KLHL15 TRIM77 HSPBP1 CBFB VCPIP1 NEDD4	4.06e-04	811	58	9	GO:0016567
GeneOntologyBiologicalProcess	neuromuscular process	MYH3 MYH7 NPR2 WASHC4 GRIN2B	4.23e-04	225	58	5	GO:0050905
GeneOntologyCellularComponent	muscle myosin complex	MYH3 MYH6 MYH7 MYH13	8.21e-08	16	56	4	GO:0005859
GeneOntologyCellularComponent	myosin filament	MYH3 MYH6 MYH7 MYH13	5.60e-07	25	56	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH3 MYH6 MYH7 MYH13	9.01e-07	28	56	4	GO:0016460
GeneOntologyCellularComponent	myosin complex	MYH3 MYH6 MYH7 MYH13	1.88e-05	59	56	4	GO:0016459
GeneOntologyCellularComponent	myofibril	MYH3 MYH6 MYH7 MYH13 GRIN2B RYR3	8.82e-05	273	56	6	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	MYH3 MYH6 MYH7 MYH13 GRIN2B RYR3	1.23e-04	290	56	6	GO:0043292
GeneOntologyCellularComponent	sarcomere	MYH3 MYH6 MYH7 GRIN2B RYR3	5.36e-04	249	56	5	GO:0030017
GeneOntologyCellularComponent	Z disc	MYH6 MYH7 GRIN2B RYR3	7.18e-04	151	56	4	GO:0030018
GeneOntologyCellularComponent	I band	MYH6 MYH7 GRIN2B RYR3	1.02e-03	166	56	4	GO:0031674
GeneOntologyCellularComponent	glutamatergic synapse	CACNA2D1 NEDD4L LRRC7 GRIN2B MAP2K1 TMEM240 HTT NEDD4	1.42e-03	817	56	8	GO:0098978
Domain	Myosin_N	MYH3 MYH6 MYH7 MYH13	1.04e-07	15	57	4	PF02736
Domain	Myosin_N	MYH3 MYH6 MYH7 MYH13	1.04e-07	15	57	4	IPR004009
Domain	Myosin_tail_1	MYH3 MYH6 MYH7 MYH13	2.31e-07	18	57	4	PF01576
Domain	Myosin_tail	MYH3 MYH6 MYH7 MYH13	2.31e-07	18	57	4	IPR002928
Domain	Myosin-like_IQ_dom	MYH3 MYH6 MYH7 MYH13	2.92e-07	19	57	4	IPR027401
Domain	-	MYH3 MYH6 MYH7 MYH13	2.92e-07	19	57	4	4.10.270.10
Domain	Myosin_head_motor_dom	MYH3 MYH6 MYH7 MYH13	5.33e-06	38	57	4	IPR001609
Domain	MYOSIN_MOTOR	MYH3 MYH6 MYH7 MYH13	5.33e-06	38	57	4	PS51456
Domain	Myosin_head	MYH3 MYH6 MYH7 MYH13	5.33e-06	38	57	4	PF00063
Domain	MYSc	MYH3 MYH6 MYH7 MYH13	5.33e-06	38	57	4	SM00242
Domain	HECT	AREL1 NEDD4L NEDD4	7.48e-05	27	57	3	PF00632
Domain	HECTc	AREL1 NEDD4L NEDD4	7.48e-05	27	57	3	SM00119
Domain	HECT_dom	AREL1 NEDD4L NEDD4	7.48e-05	27	57	3	IPR000569
Domain	HECT	AREL1 NEDD4L NEDD4	7.48e-05	27	57	3	PS50237
Domain	IQ	MYH3 MYH6 MYH7 MYH13	1.09e-04	81	57	4	SM00015
Domain	IQ_motif_EF-hand-BS	MYH3 MYH6 MYH7 MYH13	1.64e-04	90	57	4	IPR000048
Domain	IQ	MYH3 MYH6 MYH7 MYH13	1.86e-04	93	57	4	PS50096
Domain	Pyridoxal_deC	GAD1 CSAD	2.53e-04	8	57	2	PF00282
Domain	DDC_GAD_HDC_YDC	GAD1 CSAD	2.53e-04	8	57	2	PS00392
Domain	PyrdxlP-dep_de-COase	GAD1 CSAD	2.53e-04	8	57	2	IPR002129
Domain	Glyco_trans_31	B3GNT7 B3GNT3	1.07e-03	16	57	2	IPR002659
Domain	Galactosyl_T	B3GNT7 B3GNT3	1.07e-03	16	57	2	PF01762
Domain	IQ	MYH3 MYH6 MYH13	1.33e-03	71	57	3	PF00612
Domain	GUANYLATE_CYCLASE_1	NPR2 GUCY1B2	1.51e-03	19	57	2	PS00452
Domain	Guanylate_cyc	NPR2 GUCY1B2	1.51e-03	19	57	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR2 GUCY1B2	1.51e-03	19	57	2	PS50125
Domain	A/G_cyclase	NPR2 GUCY1B2	1.51e-03	19	57	2	IPR001054
Domain	CYCc	NPR2 GUCY1B2	1.51e-03	19	57	2	SM00044
Domain	ARM-type_fold	DOCK9 EIF3K HSPBP1 RYR3 HTT	3.70e-03	339	57	5	IPR016024
Domain	-	GAD1 CSAD	5.10e-03	35	57	2	3.90.1150.10
Domain	PyrdxlP-dep_Trfase_major_sub2	GAD1 CSAD	5.39e-03	36	57	2	IPR015422
Domain	ANF_lig-bd_rcpt	NPR2 GRIN2B	5.69e-03	37	57	2	IPR001828
Domain	ANF_receptor	NPR2 GRIN2B	5.69e-03	37	57	2	PF01094
Domain	Peripla_BP_I	NPR2 GRIN2B	6.31e-03	39	57	2	IPR028082
Domain	-	GAD1 CSAD	6.31e-03	39	57	2	3.40.640.10
Domain	PyrdxlP-dep_Trfase	GAD1 CSAD	6.95e-03	41	57	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	GAD1 CSAD	6.95e-03	41	57	2	IPR015421
Domain	WW	NEDD4L NEDD4	9.06e-03	47	57	2	PF00397
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH3 MYH6 MYH7 MYH13	4.45e-05	70	40	4	M12294
Pathway	REACTOME_MUSCLE_CONTRACTION	MYH3 MYH6 NPR2 GUCY1B2 RYR3	9.77e-05	165	40	5	MM15026
Pathway	WP_ENDOTHELIN_PATHWAYS	GUCY1B2 MAP2K1 CNN1	1.09e-04	33	40	3	M39651
Pathway	WP_ETHANOL_METABOLISM_PRODUCTION_OF_ROS_BY_CYP2E1	CYP2E1 MAP2K1	2.79e-04	9	40	2	M39481
Pathway	KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM	GAD1 CSAD	3.48e-04	10	40	2	M12882
Pathway	WP_ETHANOL_METABOLISM_RESULTING_IN_PRODUCTION_OF_ROS_BY_CYP2E1	CYP2E1 MAP2K1	3.48e-04	10	40	2	MM15821
Pubmed	Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.	MYH3 MYH6 MYH7	4.88e-09	3	60	3	1939265
Pubmed	Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.	MYH3 MYH6 MYH7	4.88e-09	3	60	3	1694848
Pubmed	Developmental regulation of myosin gene expression in mouse cardiac muscle.	MYH3 MYH6 MYH7	4.87e-08	5	60	3	2277065
Pubmed	Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.	MYH3 MYH6 MYH7	9.73e-08	6	60	3	28381556
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	UBA1 NEDD4L NEDD4	1.70e-07	7	60	3	30587574
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH3 MYH7 MYH13	1.70e-07	7	60	3	35210422
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH3 MYH6 MYH7	1.70e-07	7	60	3	16819597
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH3 MYH6 MYH7	2.72e-07	8	60	3	3864153
Pubmed	Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.	MYH6 MYH7 MYH13	1.06e-06	12	60	3	8424456
Pubmed	DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death.	MYH3 MYH6 MYH7	2.69e-06	16	60	3	22090424
Pubmed	Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.	MYH6 MYH7	2.93e-06	2	60	2	21526716
Pubmed	Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.	MYH6 MYH7	2.93e-06	2	60	2	18480046
Pubmed	Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.	NEDD4L NEDD4	2.93e-06	2	60	2	11502596
Pubmed	Murine pulmonary myocardium: developmental analysis of cardiac gene expression.	MYH6 MYH7	2.93e-06	2	60	2	7919499
Pubmed	Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias.	MYH6 MYH7	2.93e-06	2	60	2	34384224
Pubmed	Characterization of human cardiac myosin heavy chain genes.	MYH6 MYH7	2.93e-06	2	60	2	2726733
Pubmed	Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.	NEDD4L NEDD4	2.93e-06	2	60	2	23262292
Pubmed	Human cardiac myosin heavy chain gene mapped within chromosome region 14q11.2----q13.	MYH6 MYH7	2.93e-06	2	60	2	2494889
Pubmed	Human cardiac myosin heavy chain genes and their linkage in the genome.	MYH6 MYH7	2.93e-06	2	60	2	3037493
Pubmed	β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.	MYH6 MYH7	2.93e-06	2	60	2	21778428
Pubmed	Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.	NEDD4L NEDD4	2.93e-06	2	60	2	19602703
Pubmed	Structural organization of the human cardiac alpha-myosin heavy chain gene (MYH6).	MYH6 MYH7	2.93e-06	2	60	2	8307559
Pubmed	Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease.	GRIN2B HTT	2.93e-06	2	60	2	15240759
Pubmed	A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.	NEDD4L NEDD4	2.93e-06	2	60	2	11149908
Pubmed	Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues.	UBA1 HTT	2.93e-06	2	60	2	24948797
Pubmed	Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.	NEDD4L NEDD4	2.93e-06	2	60	2	31802037
Pubmed	Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.	MYH6 MYH7	2.93e-06	2	60	2	2969919
Pubmed	In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.	GRIN2B HTT	2.93e-06	2	60	2	19279257
Pubmed	All-atom molecular dynamics simulations of actin-myosin interactions: a comparative study of cardiac α myosin, β myosin, and fast skeletal muscle myosin.	MYH6 MYH7	2.93e-06	2	60	2	24224850
Pubmed	Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.	MYH6 MYH7	2.93e-06	2	60	2	17575272
Pubmed	Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium.	MYH6 MYH7	2.93e-06	2	60	2	16088376
Pubmed	Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences.	MYH6 MYH7	2.93e-06	2	60	2	1776652
Pubmed	Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.	MYH6 MYH7	2.93e-06	2	60	2	9884344
Pubmed	Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes.	MYH6 MYH7	2.93e-06	2	60	2	12750067
Pubmed	Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.	MYH6 MYH7	2.93e-06	2	60	2	9541509
Pubmed	Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.	MYH6 MYH7	2.93e-06	2	60	2	23580644
Pubmed	Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.	HSPBP1 HTT	2.93e-06	2	60	2	28847953
Pubmed	GluN2B-containing NMDA receptors promote glutamate synapse development in hippocampal interneurons.	GAD1 GRIN2B	2.93e-06	2	60	2	25429143
Pubmed	Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.	NEDD4L NEDD4	2.93e-06	2	60	2	37962894
Pubmed	β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.	MYH6 MYH7	2.93e-06	2	60	2	24829265
Pubmed	Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.	MYH6 MYH7	2.93e-06	2	60	2	2036722
Pubmed	Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.	MYH6 MYH7	2.93e-06	2	60	2	25937279
Pubmed	Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.	MYH6 MYH7	2.93e-06	2	60	2	15621050
Pubmed	Inhibition of N-glycan processing modulates the network of EDEM3 interactors.	UBA1 NEDD4L HSPBP1 VCPIP1	2.95e-06	57	60	4	28366632
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PCGF6 MYH3 MYH6 MYH7 WASHC4 MYH13 EIF3K IDH3B MAP2K1 CNN1	3.30e-06	910	60	10	36736316
Pubmed	Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.	MYH6 MYH7 CNN1	4.64e-06	19	60	3	18316483
Pubmed	Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.	NEDD4L NEDD4	8.77e-06	3	60	2	18498246
Pubmed	Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus.	MYH6 MYH7	8.77e-06	3	60	2	8620598
Pubmed	Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.	NEDD4L NEDD4	8.77e-06	3	60	2	21852580
Pubmed	The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.	NEDD4L NEDD4	8.77e-06	3	60	2	22361880
Pubmed	Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.	NEDD4L NEDD4	8.77e-06	3	60	2	15217910
Pubmed	Aggregate-centered redistribution of proteins by mutant huntingtin.	HSPBP1 HTT	8.77e-06	3	60	2	17208201
Pubmed	Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.	MYH6 MYH7	8.77e-06	3	60	2	18362229
Pubmed	Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.	NEDD4L NEDD4	8.77e-06	3	60	2	19423771
Pubmed	Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.	MYH6 MYH7	8.77e-06	3	60	2	20923879
Pubmed	Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.	NEDD4L NEDD4	8.77e-06	3	60	2	12050153
Pubmed	Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.	NEDD4L NEDD4	8.77e-06	3	60	2	20730100
Pubmed	Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1.	NEDD4L NEDD4	8.77e-06	3	60	2	26823285
Pubmed	Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.	NEDD4L NEDD4	8.77e-06	3	60	2	23686771
Pubmed	Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.	MYH6 MYH7	8.77e-06	3	60	2	18755891
Pubmed	Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.	NEDD4L NEDD4	8.77e-06	3	60	2	11779188
Pubmed	Mutation in myosin heavy chain 6 causes atrial septal defect.	MYH6 MYH7	8.77e-06	3	60	2	15735645
Pubmed	Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.	NEDD4L NEDD4	8.77e-06	3	60	2	12729930
Pubmed	Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.	MAP2K1 HTT	8.77e-06	3	60	2	26660732
Pubmed	Identification of three developmentally controlled isoforms of human myosin heavy chains.	MYH3 MYH7	8.77e-06	3	60	2	1691980
Pubmed	14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.	NEDD4L NEDD4	8.77e-06	3	60	2	15677482
Pubmed	The effects of slow skeletal troponin I expression in the murine myocardium are influenced by development-related shifts in myosin heavy chain isoform.	MYH6 MYH7	8.77e-06	3	60	2	22966157
Pubmed	Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest.	MYH6 MYH7	8.77e-06	3	60	2	11066038
Pubmed	Overlapping functions of SIX homeoproteins during embryonic myogenesis.	MYH3 MYH7 CNN1	9.63e-06	24	60	3	37267426
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	AREL1 NEDD4L NEDD4	1.23e-05	26	60	3	26949039
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH3 MYH6 MYH7 UBA1 MYH13 XPNPEP3 EIF3K IDH3B	1.50e-05	647	60	8	26618866
Pubmed	SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.	NEDD4L NEDD4	1.75e-05	4	60	2	28608480
Pubmed	The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.	NEDD4L NEDD4	1.75e-05	4	60	2	20026598
Pubmed	C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms.	NEDD4L NEDD4	1.75e-05	4	60	2	31357244
Pubmed	Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.	NEDD4L NEDD4	1.75e-05	4	60	2	29897283
Pubmed	Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.	MYH6 MYH7	1.75e-05	4	60	2	9927321
Pubmed	Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.	MYH6 MYH7	1.75e-05	4	60	2	25900833
Pubmed	Changes in expression of nonmuscle myosin heavy chain isoforms during muscle and nonmuscle tissue development.	MYH6 MYH7	1.75e-05	4	60	2	8482409
Pubmed	The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.	NEDD4L NEDD4	1.75e-05	4	60	2	27466427
Pubmed	GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.	NEDD4L NEDD4	1.75e-05	4	60	2	17544362
Pubmed	NEDD4-2 associates with gamma(c) and regulates its degradation rate.	NEDD4L NEDD4	1.75e-05	4	60	2	19615332
Pubmed	Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.	NEDD4L NEDD4	1.75e-05	4	60	2	22024150
Pubmed	SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.	ZFHX3 PIAS2	1.75e-05	4	60	2	32249212
Pubmed	Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.	NEDD4L NEDD4	1.75e-05	4	60	2	11696533
Pubmed	Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.	NEDD4L NEDD4	1.75e-05	4	60	2	21463633
Pubmed	Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.	MYH6 MYH7	1.75e-05	4	60	2	11815426
Pubmed	ERK activation causes epilepsy by stimulating NMDA receptor activity.	GRIN2B MAP2K1	1.75e-05	4	60	2	17972914
Pubmed	Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages.	MYH6 MYH7	1.75e-05	4	60	2	28806941
Pubmed	Murine cardiac progenitor cells require visceral embryonic endoderm and primitive streak for terminal differentiation.	MYH6 MYH7	1.75e-05	4	60	2	9389458
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBA1 NEDD4L PIAS2 NEDD4	2.27e-05	95	60	4	29643511
Pubmed	Role of the NR2A/2B subunits of the N-methyl-D-aspartate receptor in glutamate-induced glutamic acid decarboxylase alteration in cortical GABAergic neurons in vitro.	GAD1 GRIN2B	2.92e-05	5	60	2	20923697
Pubmed	Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.	NEDD4L NEDD4	2.92e-05	5	60	2	30287686
Pubmed	An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.	NEDD4L NEDD4	2.92e-05	5	60	2	18687683
Pubmed	Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.	NEDD4L NEDD4	2.92e-05	5	60	2	21478478
Pubmed	Recruitment of intra- and extracardiac cells into the myocardial lineage during mouse development.	MYH6 MYH7	2.92e-05	5	60	2	12629673
Pubmed	Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.	MYH6 MYH7	2.92e-05	5	60	2	2552320
Pubmed	The ESCRT pathway and HIV-1 budding.	NEDD4L NEDD4	2.92e-05	5	60	2	19143627
Pubmed	Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.	NEDD4L NEDD4	2.92e-05	5	60	2	19617352
Pubmed	Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.	NEDD4L NEDD4	2.92e-05	5	60	2	25631046
Pubmed	The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.	NEDD4L NEDD4	2.92e-05	5	60	2	17289006
Interaction	ACTN2 interactions	MYH3 MYH6 MYH7 LRRC7 GRIN2B HTT	1.06e-05	171	59	6	int:ACTN2
Interaction	MAP2 interactions	NEDD4L EIF3K GRIN2B HTT NEDD4	1.33e-05	104	59	5	int:MAP2
Interaction	CDK3 interactions	MYH3 MYH6 MYH7 NEDD4L MYH13	2.08e-05	114	59	5	int:CDK3
Interaction	LATS1 interactions	PCGF6 MYH3 MYH6 MYH7 MYH13 DNAJC9 IDH3B NEDD4	4.05e-05	440	59	8	int:LATS1
Interaction	KCNAB1 interactions	NEDD4L HTT NEDD4	5.24e-05	25	59	3	int:KCNAB1
Cytoband	14q12	MYH6 MYH7	2.39e-03	55	60	2	14q12
GeneFamily	Myosin heavy chains	MYH3 MYH6 MYH7 MYH13	2.23e-08	15	38	4	1098
GeneFamily	OTU domain containing	OTULINL VCPIP1	5.73e-04	17	38	2	669
GeneFamily	Beta 3-glycosyltransferases	B3GNT7 B3GNT3	1.15e-03	24	38	2	426
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#2_top-relative-expression-ranked_500	CACNA2D1 WASHC4 NAB1 RYR3	9.89e-06	51	56	4	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_500_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_top-relative-expression-ranked_500	MYH3 CACNA2D1 MYH7 LMCD1 GSDMC CNN1 RYR3	6.91e-05	388	56	7	gudmap_developingLowerUrinaryTract_P1_bladder_500_J
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#3_top-relative-expression-ranked_200	MYH3 MYH7	1.02e-04	6	56	2	gudmap_developingLowerUrinaryTract_e14.5_ urethra_200_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#1_top-relative-expression-ranked_1000	CACNA2D1 MYH7 CNN1 RYR3	1.02e-04	92	56	4	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_500	CACNA2D1 CNN1 RYR3	1.73e-04	41	56	3	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_ureteral tissue_emap-8234_k-means-cluster#4_top-relative-expression-ranked_100	MYH3 MYH7	1.89e-04	8	56	2	gudmap_developingLowerUrinaryTract_e15.5_ureteral tissue_100_k4
ToppCell	facs-Trachea-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 ARHGDIG MYH7 RP1 CFAP43	3.97e-06	176	60	5	ed788a5969edfd1199828ca5b0dd34e7f29c4d30
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA2D1 MYH6 MYH7 LMCD1 CNN1	3.97e-06	176	60	5	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	GAD1 CACNA2D1 LMCD1 OTULINL CNN1	4.80e-06	183	60	5	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 LRRC7 GRIN2B RYR3	4.80e-06	183	60	5	9533db4db2c6ae78d7ca1682cf4efed12183396f
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 LRRC7 GRIN2B RYR3	4.80e-06	183	60	5	bf7f1cb55ed55981b8b355d5774055c96e658ff2
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LMCD1 ZFHX3 LRRC7 OTULINL CNN1	5.47e-06	188	60	5	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZFHX3 LRRC7 OTULINL CNN1 RYR3	5.62e-06	189	60	5	b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1 RYR3	5.62e-06	189	60	5	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1 RYR3	5.62e-06	189	60	5	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 LRRC7 GRIN2B RYR3	5.62e-06	189	60	5	851f8144aed5c7f80302911cd6b03f14bde7b56d
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 LRRC7 GRIN2B RYR3	5.62e-06	189	60	5	3e8e30160a8d6f531ff743cb5918c9e79481f1bd
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 LRRC7 GRIN2B RYR3	5.76e-06	190	60	5	1c5cf933ce71fed5638b9ef31eb81f6c2b6dadbc
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA2D1 CYP2E1 LMCD1 OTULINL CNN1	6.54e-06	195	60	5	2414b158dc7bdec43a9671544bfb7ffc5f5168fd
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-PNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	CACNA2D1 ARHGDIG DOCK9 LRRC7 GRIN2B	6.87e-06	197	60	5	10e72b425a2bcba35e63a5b074d3dedcd49a762e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	GAD1 CACNA2D1 NEDD4L ZFHX3 GRIN2B	7.39e-06	200	60	5	68c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCell	Severe-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CACNA2D1 WASHC4 TRIM77 TBC1D21	1.54e-05	111	60	4	7021009545178fac1f19f3c429bfedb2f38b680d
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH6 MYH7 RYR3	5.98e-05	157	60	4	9021900d9b1a71210c9c414a9d165eaf399eb607
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH6 MYH7 RYR3	5.98e-05	157	60	4	c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYH6 GRIN2B CNN1 RYR3	8.32e-05	171	60	4	82de2885c8ce4fb7776da6a0207b3355c0910121
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYH6 GRIN2B CNN1 RYR3	8.32e-05	171	60	4	09e653973962fb884878089d281f0947f7a285f6
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1	8.51e-05	172	60	4	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1	8.51e-05	172	60	4	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 GRIN2B PNMA3	9.72e-05	178	60	4	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 GRIN2B PNMA3	9.72e-05	178	60	4	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA2D1 MYH6 MYH7 LRRC2	1.04e-04	181	60	4	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 LRRC7 RYR3	1.06e-04	182	60	4	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 MYH7 LRRC7 RYR3	1.06e-04	182	60	4	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA2D1 MYH7 LMCD1 CNN1	1.06e-04	182	60	4	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZFHX3 LRRC7 OTULINL CNN1	1.08e-04	183	60	4	e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA2D1 MYH6 MYH7 LRRC2	1.13e-04	185	60	4	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH3 MYH13 GRIN2B TSSK3	1.15e-04	186	60	4	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D1 MYH6 ZFHX3 CNN1	1.20e-04	188	60	4	d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1	1.20e-04	188	60	4	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1	1.20e-04	188	60	4	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1	1.20e-04	188	60	4	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1	1.22e-04	189	60	4	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MYH7 LRRC2 RP1	1.22e-04	189	60	4	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA2D1 LMCD1 ZFHX3 CNN1	1.22e-04	189	60	4	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA2D1 MYH6 MYH7 LRRC2	1.25e-04	190	60	4	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D1 MYH6 ZFHX3 CNN1	1.27e-04	191	60	4	8597a8af294f24496c317d995f07eb5dcc25c13c
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	LMCD1 ZFHX3 LRRC7 CNN1	1.30e-04	192	60	4	7ae3e1ca8bfc078c0e12a1595ecb0e343dab5d2f
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LMCD1 GRIN2B OTULINL CNN1	1.30e-04	192	60	4	93903576dddd8227328e4ced75aa7625eedb9baf
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LMCD1 GRIN2B OTULINL CNN1	1.33e-04	193	60	4	cfab88935abe0a15632c5eec8ff00a857ec9b3ed
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D1 MYH6 ZFHX3 CNN1	1.35e-04	194	60	4	80be44e9ddd9f6ddd9dff7cba0eb457431204c2d
ToppCell	P28-Mesenchymal-myocytic_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP2E1 LMCD1 OTULINL CNN1	1.35e-04	194	60	4	83e45441c74b7f50b6725876b583229280179dc2
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA2D1 CYP2E1 LMCD1 OTULINL	1.38e-04	195	60	4	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP2E1 LMCD1 OTULINL CNN1	1.38e-04	195	60	4	2eed0332e338d6f0dbcb399d9d36c4611d491b0a
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA2D1 CYP2E1 LMCD1 OTULINL	1.38e-04	195	60	4	a486a7acea0e91048cc48afa0dbd3926d30bc217
ToppCell	P15-Mesenchymal-myocytic_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP2E1 LMCD1 OTULINL CNN1	1.41e-04	196	60	4	41ae5b0d81ad09a6663335d899b4a1e4976c3b62
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP2E1 LMCD1 OTULINL CNN1	1.41e-04	196	60	4	acbb493dbb49a33f20cf11106363f7ed51209706
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	DOCK9 LRRC7 GRIN2B OTULINL	1.41e-04	196	60	4	c9e7ac34993c873de4f198cdae77dcf099731532
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	GAD1 ARHGDIG ZFHX3 GRIN2B	1.44e-04	197	60	4	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	GAD1 NEDD4L CHD9 LRRC7	1.46e-04	198	60	4	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	CACNA2D1 LRRC7 GRIN2B LRRC73	1.46e-04	198	60	4	60d8d3bbd754ffde41c50013d822667b185a9751
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal\|10w / Sample Type, Dataset, Time_group, and Cell type.	GAD1 CACNA2D1 NEDD4L GRIN2B	1.52e-04	200	60	4	979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	CACNA2D1 DOCK9 CSAD LRRC7	1.52e-04	200	60	4	0cb0755a101ec655359d051d6a8807408d727c55
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Syt15_(Medial_habenula)\|Thalamus / BrainAtlas - Mouse McCarroll V32	MYH6 MYH13 TSSK3	1.54e-04	77	60	3	7f624e9262bd0dc2ac4176f43c91a4bc0f521fe5
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GUCY1B2 MYH13 B3GNT7	1.85e-04	82	60	3	15bc417aaace2b1d680904a622fe76e95083c9ff
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GUCY1B2 MYH13 B3GNT7	1.85e-04	82	60	3	697e1da3095c8483b8181b290fa5417bdc9cee54
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GUCY1B2 MYH13 B3GNT7	1.85e-04	82	60	3	73349906bcc8d1a40dc03df7a490a963e85564f2
Drug	fast white	MYH3 HARS2 MYH6 MYH7 MYH13	8.46e-08	42	60	5	CID000024008
Drug	SM-2	MYH3 MYH6 MYH7 MYH13 CNN1	3.36e-06	87	60	5	CID000486033
Drug	formycin triphosphate	MYH3 MYH6 MYH7 MYH13	9.92e-06	51	60	4	CID000122274
Drug	creatine	MYH3 CACNA2D1 MYH6 MYH7 MYH13 RYR3	1.17e-05	193	60	6	CID000000586
Drug	nifedipine	MYH3 CACNA2D1 MYH6 MYH7 MYH13 CYP2E1 GRIN2B RYR3	1.27e-05	415	60	8	CID000004485
Drug	Propranolol hydrochloride [318-98-9]; Down 200; 13.6uM; PC3; HT_HG-U133A	ARHGDIG CYP2E1 LMCD1 NAB1 CBFB CNN1	1.40e-05	199	60	6	6759_DN
Drug	AC1NBU2S	CACNA2D1 NPR2 GUCY1B2 MAP2K1 RYR3	1.43e-05	117	60	5	CID004473765
Drug	B0683	MYH3 CACNA2D1 MYH6 MYH7 MYH13	1.43e-05	117	60	5	CID006398969
Drug	K-Cl	MYH3 CACNA2D1 MYH6 MYH7 NPR2 MYH13 CSAD CNN1 RYR3	1.65e-05	567	60	9	CID000004873
Drug	purealin	MYH3 MYH6 MYH7 MYH13	1.66e-05	58	60	4	CID006419303
Drug	2bq7	MYH3 MYH6 MYH7 MYH13 CYP2E1	1.83e-05	123	60	5	CID006540267
Drug	indo-1/AM	CACNA2D1 NPR2 RYR3	2.24e-05	21	60	3	CID000123918
Drug	AC1LADJ6	MYH3 MYH6 MYH7 MYH13 CNN1	2.39e-05	130	60	5	CID000486032
Drug	clenbuterol	MYH3 ARHGDIG MYH6 MYH7 MYH13	3.64e-05	142	60	5	CID000002783
Drug	candesartan cilexetil	MYH3 CACNA2D1 MYH6 MYH7 MYH13	4.03e-05	145	60	5	CID000002540
Drug	AC1N9ZZC	MYH3 MYH6 MYH7 MYH13 RYR3	4.59e-05	149	60	5	CID004369374
Drug	N-methyl-DL-aspartic acid	GAD1 CACNA2D1 NPR2 CSAD LRRC7 GRIN2B MAP2K1 RYR3 HTT	5.09e-05	655	60	9	CID000004376
Drug	eye gene	MYH3 CACNA2D1 MYH6 MYH7 NPR2 MYH13 MAP2K1	5.12e-05	369	60	7	CID000004782
Drug	carvedilol	MYH3 CACNA2D1 MYH6 MYH7 MYH13	6.63e-05	161	60	5	CID000002585
Drug	5-hexyn-1-ol	CACNA2D1 CYP2E1	6.79e-05	5	60	2	CID000070234
Drug	in1372	CACNA2D1 MAP2K1	6.79e-05	5	60	2	CID010068193
Drug	anipamil	CACNA2D1 MYH6	6.79e-05	5	60	2	CID000054966
Drug	monomethylarsonous acid	MYH3 MYH6 NEDD4L LMCD1 DOCK9 CTDSP1 MAP2K1 GSDMC CNN1	7.94e-05	694	60	9	ctd:C406082
Drug	nitric oxide	GAD1 CACNA2D1 HARS2 NPR2 GUCY1B2 CYP2E1 CSAD GRIN2B IDH3B MAP2K1 RYR3	1.01e-04	1075	60	11	CID000145068
Drug	GC 1 compound	MYH6 MYH7	1.02e-04	6	60	2	ctd:C413355
Drug	NSC-10458	MYH6 CYP2E1	1.02e-04	6	60	2	CID005351637
Drug	chloro-m-cresol	CACNA2D1 RYR3	1.02e-04	6	60	2	CID000012008
Drug	2,5-dihydro-2,4,5-trimethylthiazoline	GAD1 CACNA2D1	1.02e-04	6	60	2	ctd:C411827
Drug	nitroxyl	NPR2 GUCY1B2 GRIN2B MAP2K1 PIAS2	1.28e-04	185	60	5	CID000000945
Drug	S-(-)-Etomoxir	MYH3 MYH6 MYH7 MYH13	1.41e-04	100	60	4	CID000060765
Drug	Azumoleno	CACNA2D1 RYR3	1.42e-04	7	60	2	CID000056259
Drug	CHEBI:564108	CACNA2D1 RYR3	1.42e-04	7	60	2	CID006400637
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	CACNA2D1 NPR2 GUCY1B2 MAP2K1 CNN1 RYR3	1.58e-04	308	60	6	CID000001915
Drug	arabinosyladenine	MYH3 CACNA2D1 HARS2 MYH6 NPR2 GUCY1B2 IDH3B MAP2K1 RYR3	1.61e-04	762	60	9	CID000000191
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.42e-09	10	56	4	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	5.69e-09	12	56	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	5.69e-09	12	56	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	8.21e-09	13	56	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	1.56e-08	15	56	4	DOID:0050646 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	2.13e-06	48	56	4	DOID:423 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	1.03e-05	71	56	4	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH7 MYH13	1.65e-05	80	56	4	DOID:12930 (implicated_via_orthology)
Disease	Caveolinopathy	MYH6 MYH7	2.12e-05	4	56	2	cv:C5679790
Disease	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1	MYH6 MYH7	2.12e-05	4	56	2	192600
Disease	Cardiomyopathy, Familial Hypertrophic, 1 (disorder)	MYH6 MYH7	2.12e-05	4	56	2	C3495498
Disease	Hypertrophic cardiomyopathy 1	MYH6 MYH7	2.12e-05	4	56	2	cv:C3495498
Disease	Liddle syndrome (implicated_via_orthology)	NEDD4L NEDD4	2.12e-05	4	56	2	DOID:0050477 (implicated_via_orthology)
Disease	Epileptic encephalopathy	NEDD4L GRIN2B RYR3	2.53e-05	30	56	3	C0543888
Disease	Idiopathic hypertrophic subaortic stenosis	MYH6 MYH7	7.38e-05	7	56	2	C0700053
Disease	Obstructive asymmetric septal hypertrophy	MYH6 MYH7	7.38e-05	7	56	2	C0597124
Disease	Cardiomyopathy, Hypertrophic, Familial	MYH6 MYH7	1.26e-04	9	56	2	C0949658
Disease	Muscular dystrophy, limb-girdle, autosomal dominant	MYH6 MYH7	1.58e-04	10	56	2	cv:C5675009
Disease	Mitral valve prolapse, response to surgery	AREL1 LMCD1	2.31e-04	12	56	2	EFO_0009951, HP_0001634
Disease	glycerol-3-phosphate measurement	NEDD4L CFAP43	3.66e-04	15	56	2	EFO_0010488
Disease	Sinus Node Dysfunction (disorder)	CACNA2D1 MYH6	3.66e-04	15	56	2	C0428908
Disease	Primary familial hypertrophic cardiomyopathy	MYH6 MYH7	7.98e-04	22	56	2	cv:C0949658
Disease	Huntington's disease (is_implicated_in)	GRIN2B HTT	8.72e-04	23	56	2	DOID:12858 (is_implicated_in)
Disease	Hypertrophic obstructive cardiomyopathy	MYH6 MYH7	1.03e-03	25	56	2	C4551472
Disease	Limb-girdle muscular dystrophy	MYH6 MYH7	1.12e-03	26	56	2	cv:C0686353
Disease	suicidal ideation	AREL1 ZFHX3	1.39e-03	29	56	2	EFO_0004320
Disease	bipolar disorder (is_implicated_in)	GAD1 GRIN2B	1.39e-03	29	56	2	DOID:3312 (is_implicated_in)
Disease	Primary familial dilated cardiomyopathy	MYH6 MYH7	1.49e-03	30	56	2	cv:C0340427
Disease	Heart Failure, Diastolic	MYH6 MYH7	1.80e-03	33	56	2	C1135196

Protein segments in the cluster

Peptide	Gene	Start	Entry
DLYIGCEEGHLLMIN	CFAP43	266	Q8NDM7
LLLMADDLGIGDIGC	ARSL	41	P51690
FDCMGEEDLINLGVI	FAM106A	151	Q4KMX7
GLLEECGLRMELDNP	GSDMC	466	Q9BYG8
ELGCFQLELRGDVEM	NPR2	1011	P20594
LELMFGCQVEGDAAE	MAP2K1	271	Q02750
VCAGEGLARMELFLL	CYP2E1	436	P05181
IDFGMDLQACIDLIE	MYH7	511	P12883
FDCMGEEDLINLGVI	FAM106C	151	P0CH98
IFDENELELLMCGLG	NEDD4	1186	P46934
ELELLMCGLGDVDVN	NEDD4	1191	P46934
DMDISGCEALEDLLL	LRRC7	246	Q96NW7
LCEAGEEEFLEIMAL	NAB1	41	Q13506
QLLEGMEGFNLELSD	GAD1	146	Q99259
LQRLDGMGCLEFDEE	CBFB	116	Q13951
DEFLQRMGELFECVL	CTDSP1	136	Q9GZU7
DCSGNLELMELPFEL	LRRC2	196	Q9BYS8
TFGKLGCDLDMFLDL	MTPAP	236	Q9NVV4
CRGLLENELKLMEEF	LMCD1	171	Q9NZU5
VGDTCGLEQIDMFIL	OTULINL	291	Q9NUU6
FEMILGGCGELNAIE	CHD9	976	Q3L8U1
GIAMELFLLCSDDAE	HTT	126	P42858
IMKLGDGLFLQCCEE	IDH3B	221	O43837
ENCAEIMRLLDDFGV	KLHL15	131	Q96M94
LGRELMLQLSEFLCE	CPN1	91	P15169
EDVLMELLEQCADGL	DOCK9	1711	Q9BZ29
MLGLDACELGAQLLE	ARHGDIG	1	Q99819
DVMDCVILDDGGFLL	CACNA2D1	846	P54289
MEGCRNLLGLLDNDE	C3orf38	11	Q5JPI3
DENELELLMCGTGDI	AREL1	696	O15033
LDENMDLLEGITGFE	EIF3K	121	Q9UBQ5
DDVFLGMCLELEGLK	B3GNT3	296	Q9Y2A9
CADMDFLLNELERLG	CSAD	476	Q9Y600
MGLLDLCEEVFGTAD	DNAJC9	1	Q8WXX5
DDVFLGMCLEVLGVQ	B3GNT7	326	Q8NFL0
LDMSLLLEFIGANEG	PCGF6	251	Q9BYE7
SLILDGLFMEILNDC	PIAS2	396	O75928
NILELCMFEGENLFI	RP1	2121	P56715
EGALELLADLCENMD	HSPBP1	121	Q9NZL4
MCEILSGLQLGDFLI	HARS2	196	P49590
ELLDVSMELGCFLAG	TMCO3	516	Q6UWJ1
MGGDDILLACNNLID	TBC1D21	291	Q8IYX1
MLILGIPEDCGEDEF	PNMA3	21	Q9UL41
LGGNLMEFIENLDAL	GUCY1B2	11	O75343
FIDFGMDLAACIELI	MYH3	511	P11055
FIDFGMDLQACIDLI	MYH6	511	P13533
MDGLKDGIILCEFIN	CNN1	51	P51911
QEIDLMLGLLLGFCI	TMEM240	86	Q5SV17
NDMRLDSEGIFLLLC	TRIM77	366	I1YAP6
NVDLEIGCLVDLAMG	RYR3	1406	Q15413
LVMELAEGGDVFDCV	TSSK3	86	Q96PN8
GGLAEDELLQLLDML	TTC41P	616	Q6P2S7
EFIDFGMDLAACIEL	MYH13	511	Q9UKX3
DMNQGELFDCALLGD	VCPIP1	151	Q96JH7
GQLFCDFGEEMILTD	UBA1	196	P22314
LIKDGEMVLLDGGCE	XPNPEP3	321	Q9NQH7
LEGQLLDGMIFQACI	WASHC4	251	Q2M389
LLDCDGGLQMKGDIF	ZFHX3	2751	Q15911
VALDLGDCMLGDEAI	LRRC73	116	Q5JTD7
VDLAILQLFGDGEME	GRIN2B	776	Q13224
LQLFGDGEMEELEAL	GRIN2B	781	Q13224
KIFDENELELLMCGL	NEDD4L	841	Q96PU5
NELELLMCGLGDVDV	NEDD4L	846	Q96PU5