Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbohydrate binding	GALNTL6 GALNT10 MAN2C1 MAN2B2 EGLN1 GBE1 PKD1L2 CILP2 IGF2R ATRNL1 PKD1	1.13e-05	310	139	11	GO:0030246
GeneOntologyMolecularFunction	3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	PDE3A PDE3B	4.81e-05	2	139	2	GO:0004119
GeneOntologyMolecularFunction	K63-linked deubiquitinase activity	USP9X YOD1 OTUD4	1.73e-04	16	139	3	GO:0061578
GeneOntologyMolecularFunction	collagen V binding	GPC1 THBS1	4.75e-04	5	139	2	GO:0070052
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F8 CYP4F12	4.75e-04	5	139	2	GO:0052871
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1D ABCC9 PKD1L2 CALHM2 CHRNE PIEZO2 TRPM5 SCN7A PKD1	6.80e-04	343	139	9	GO:0005261
GeneOntologyMolecularFunction	fibrinogen binding	ITGA2B THBS1	7.09e-04	6	139	2	GO:0070051
GeneOntologyMolecularFunction	growth factor binding	GPC1 NRP2 THBS1 IGF2R LTBP4 SDCBP	7.89e-04	156	139	6	GO:0019838
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K3 TAOK2 MOS	8.54e-04	27	139	3	GO:0004709
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F8 CYP4F12	9.87e-04	7	139	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F8 CYP4F12	9.87e-04	7	139	2	GO:0018685
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2C1 MAN2B2 ST6GAL2	1.38e-05	7	139	3	IPR011330
Domain	REJ	PKD1L2 PKD1	3.27e-04	4	139	2	PS51111
Domain	REJ_dom	PKD1L2 PKD1	3.27e-04	4	139	2	IPR014010
Domain	Glyco_hydro_38_C	MAN2C1 MAN2B2	5.42e-04	5	139	2	IPR011682
Domain	Alpha-mann_mid	MAN2C1 MAN2B2	5.42e-04	5	139	2	PF09261
Domain	Glyco_hydro_57/38_cen	MAN2C1 MAN2B2	5.42e-04	5	139	2	IPR028995
Domain	3'-5'_exonuclease_dom	EXOSC10 EXD3	5.42e-04	5	139	2	IPR002562
Domain	Glyco_hydro_38	MAN2C1 MAN2B2	5.42e-04	5	139	2	PF01074
Domain	35EXOc	EXOSC10 EXD3	5.42e-04	5	139	2	SM00474
Domain	-	MAN2C1 MAN2B2	5.42e-04	5	139	2	1.20.1270.50
Domain	-	MAN2C1 MAN2B2	5.42e-04	5	139	2	3.20.110.10
Domain	Alpha-mann_mid	MAN2C1 MAN2B2	5.42e-04	5	139	2	SM00872
Domain	Glyco_hydro_38_N	MAN2C1 MAN2B2	5.42e-04	5	139	2	IPR000602
Domain	DNA_pol_A_exo1	EXOSC10 EXD3	5.42e-04	5	139	2	PF01612
Domain	Glyco_hydro_38/57_N	MAN2C1 MAN2B2	5.42e-04	5	139	2	IPR027291
Domain	Glyco_hydro_38_cen	MAN2C1 MAN2B2	5.42e-04	5	139	2	IPR015341
Domain	Glyco_hydro_38C	MAN2C1 MAN2B2	5.42e-04	5	139	2	PF07748
Domain	PKD/REJ-like	PKD1L2 PKD1	8.09e-04	6	139	2	IPR002859
Domain	REJ	PKD1L2 PKD1	8.09e-04	6	139	2	PF02010
Domain	TFR_dimer	NAALADL1 TFR2	8.09e-04	6	139	2	PF04253
Domain	-	NAALADL1 TFR2	8.09e-04	6	139	2	1.20.930.40
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	MAN2C1 MAN2B2 USP9X GBE1 ITGA2B DDB1 ASL DIAPH1 PRKDC DYNC1H1 SON	1.77e-07	344	141	11	30333137
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 EXOSC10 USP9X ZC3H13 DDB1 NUP205 LRPPRC IGF2R DOCK7 PRKDC SPEN MED12 DYNC1H1 SON	4.77e-07	653	141	14	22586326
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MFHAS1 MYO10 RNPEPL1 L1CAM GATA2 RALGAPA2 TEP1 TAOK2 FAM20C RADIL IGF2R PIK3CD PKD1 PRKDC SPEN LTBP4 MED12 DYNC1H1	5.84e-07	1105	141	18	35748872
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TTF2 USP9X EGLN1 DDB1 LRPPRC IGF2R NDRG1 DOCK7 LRRC7 PRKDC CTNND1 MED12 DYNC1H1 CSTPP1	1.24e-06	708	141	14	39231216
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	MAN2B2 EIF4A3 L1CAM MCM7 ITGA2B TFR2 NUP205 LRPPRC CILP2 IGF2R SLC25A10 PRKDC LTBP4	1.41e-06	613	141	13	22268729
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	EIF4A3 USP9X MCM7 DDB1 NUP205 LRPPRC PRKDC DYNC1H1	1.53e-06	197	141	8	31620119
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DLGAP1 LEO1 EIF4A3 USP9X MSTO1 WAC MAGI2 THBS1 NDRG1 ATRNL1 OSBPL1A PKD1 ARID5B ASTN1 LRRN2 PRKDC SDCBP DYNC1H1	4.87e-06	1285	141	18	35914814
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	EIF4A3 USP9X MCM7 WDR11 HECW2 DOCK7 CTNND1 SPEN SDCBP	5.71e-06	313	141	9	38270169
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	VPS18 MAN2B2 RNF8 IP6K1 RALGAPA2 WAC RADIL WDR11 ATRNL1 CEP152 MED12	5.84e-06	493	141	11	15368895
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	RNF8 MCM7 DDB1 PRKDC	6.54e-06	30	141	4	34017080
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HDAC5 MYO10 MAGI2 KIRREL3 DOCK7 OTUD4 LRRC7 SPEN DYNC1H1 SON	6.83e-06	407	141	10	12693553
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	PPP2R2D USP9X MCM7 DDB1 LRPPRC PRKDC DYNC1H1	7.76e-06	175	141	7	25756610
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	GALNTL6 PDE3B ZC3H13 TSPYL6 NUP205 YOD1 FAM20C HECW2 PKD1 ARID5B LRRC7 PRKDC DYNC1H1	1.02e-05	736	141	13	29676528
Pubmed	Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.	COL10A1 S1PR3 LPAR2	1.05e-05	11	141	3	20458606
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	HDAC5 PPP2R2D EIF4A3 USP9X MCM7 DDB1 LRPPRC PRKDC	1.11e-05	258	141	8	21081666
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	MCM7 DDB1 LRPPRC DOCK7 PRKDC	1.15e-05	72	141	5	36376293
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	MAGI2 RADIL LRRC7 SDCBP	1.23e-05	35	141	4	33864728
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	PTBP3 EIF4A3 USP9X MCM7 DDB1 NUP205 LRPPRC DOCK7 PRKDC CTNND1 DYNC1H1	1.23e-05	534	141	11	35032548
Pubmed	Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.	S1PR3 LPAR2	1.63e-05	2	141	2	10537322
Pubmed	A pathophysiological role of PDE3 in allergic airway inflammation.	PDE3A PDE3B	1.63e-05	2	141	2	29367458
Pubmed	Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.	PDE3A PDE3B	1.63e-05	2	141	2	17482796
Pubmed	Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.	PDE3A PDE3B	1.63e-05	2	141	2	25877153
Pubmed	Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.	PDE3A PDE3B	1.63e-05	2	141	2	31051182
Pubmed	Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.	PDE3A PDE3B	1.63e-05	2	141	2	39435735
Pubmed	G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion.	DIAPH1 LPAR2	1.63e-05	2	141	2	24950964
Pubmed	Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.	CYP4F8 CYP4F12	1.63e-05	2	141	2	16112640
Pubmed	Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins.	PDE3A PDE3B	1.63e-05	2	141	2	21632535
Pubmed	Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.	EGLN1 NDRG1	1.63e-05	2	141	2	27827416
Pubmed	The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.	PIK3CD PRKDC	1.63e-05	2	141	2	19596993
Pubmed	RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells.	RNF8 MCM7	1.63e-05	2	141	2	39004272
Pubmed	Dopamine receptor antagonists as potential therapeutic agents for ADPKD.	HDAC5 PKD1	1.63e-05	2	141	2	31059522
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	COL10A1 COL12A1 RALGAPA2 WAC MAGI2 ZRSR2P1 TRPM5 ARID5B DCAF4L1	1.86e-05	363	141	9	14691545
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EXOSC10 RBM12B EIF4A3 USP9X MCM7 DDB1 NUP205 LRPPRC IGF2R DOCK7 PRKDC CTNND1 SPEN DYNC1H1 SON	1.90e-05	1024	141	15	24711643
Pubmed	The functional interactome landscape of the human histone deacetylase family.	TTF2 HDAC5 RBM12B USP9X SLC25A10 ARID5B PRKDC SON	2.51e-05	289	141	8	23752268
Pubmed	IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.	USP9X PRKDC DYNC1H1	2.86e-05	15	141	3	18303054
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	GBE1 MCM7 NDRG1 ARID5B PRKDC MED12 SON	3.40e-05	220	141	7	35785414
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	EXOSC10 MCM7 DDB1 LRPPRC SLC25A10 PRKDC DYNC1H1	3.50e-05	221	141	7	29991511
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PTBP3 EXOSC10 RBM12B EIF4A3 ZC3H13 DDB1 NUP205 LRPPRC SLC25A10 DOCK7 PRKDC SPEN MED12 DYNC1H1 SON	3.57e-05	1082	141	15	38697112
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TPP2 DLGAP1 USP9X DDB1 TAOK2 MAGI2 LRPPRC IGF2R DOCK7 DIAPH1 OTUD4 LRRC7 CTNND1 DYNC1H1	3.96e-05	963	141	14	28671696
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	PDE3A LEO1 USP9X ZC3H13 IFIT3 WAC NDRG1 OTUD4 SPEN SON	4.18e-05	503	141	10	16964243
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	EIF4A3 USP9X DDB1 LRPPRC OTUD4 PRKDC	4.40e-05	156	141	6	22952844
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	USP9X DDB1 WAC NDRG1 ARID5B	4.41e-05	95	141	5	29490077
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TTF2 ACACB KIZ DDB1 MSTO1 NUP205 IGF2R NDRG1 WDR11 CEP152 LTBP4 CEP97 DYNC1H1	4.69e-05	853	141	13	28718761
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	COL12A1 THBS1 SDCBP DYNC1H1	4.76e-05	49	141	4	21362503
Pubmed	Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations.	USP9X MED12	4.88e-05	3	141	2	27602765
Pubmed	Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.	ITGA2B PRKDC	4.88e-05	3	141	2	23028636
Pubmed	Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1.	PDE3A PDE3B	4.88e-05	3	141	2	8921398
Pubmed	A glial-specific voltage-sensitive Na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2.	THBS1 SCN7A	4.88e-05	3	141	2	8250913
Pubmed	Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa.	ITGA2B THBS1	4.88e-05	3	141	2	22268819
Pubmed	Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells.	PIWIL1 TDRD1	4.88e-05	3	141	2	19735482
Pubmed	Thrombospondin-induced adhesion of human platelets.	ITGA2B THBS1	4.88e-05	3	141	2	2010551
Pubmed	CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis.	THBS1 IGF2R	4.88e-05	3	141	2	38581244
Pubmed	Histone deacetylase 3 associates with and represses the transcription factor GATA-2.	HDAC5 GATA2	4.88e-05	3	141	2	11567998
Pubmed	Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation.	PDE3A PDE3B	4.88e-05	3	141	2	32949251
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GPC1 EXOSC10 RBM12B EIF4A3 ZC3H13 MCM7 DDB1 NUP205 LRPPRC THBS1 WDR11 DOCK7 PRKDC CTNND1 SPEN DYNC1H1	5.36e-05	1257	141	16	36526897
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	EIF4A3 DDB1 WDR11 MED12 DCAF4L1	5.37e-05	99	141	5	34161765
Pubmed	Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.	RNF8 DDB1 PRKDC	6.03e-05	19	141	3	34188037
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	EXOSC10 EIF4A3 USP9X MCM7 DDB1 NUP205 LRPPRC DIAPH1 PRKDC DYNC1H1 SON	6.21e-05	638	141	11	33239621
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	HDAC5 EIF4A3 USP9X MCM7 DDB1 LRPPRC DOCK7 PRKDC CTNND1 CEP97 RAD23A	6.30e-05	639	141	11	23443559
Pubmed	A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors.	CACNA1D MAGI2 CEP97	7.07e-05	20	141	3	35224516
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GPC1 TPP2 DLGAP1 VPS18 USP9X L1CAM NT5DC3 DDB1 MAGI2 LRPPRC HECW2 DOCK7 OTUD4 LRRC7 CTNND1 SDCBP DYNC1H1	7.23e-05	1431	141	17	37142655
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DLGAP1 TAOK2 LRPPRC DIAPH1 LRRC7 CTNND1 DYNC1H1	7.80e-05	251	141	7	27507650
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	EXOSC10 NT5DC3 DDB1 NUP205 CEP152 PRKDC DYNC1H1 SON	7.88e-05	340	141	8	29478914
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	EIF4A3 RADIL DOCK7 PRKDC CTNND1 DYNC1H1 SON	8.61e-05	255	141	7	15324660
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TTF2 EXOSC10 USP9X MCM7 DOCK7 PRKDC CTNND1 SPEN MED12 DYNC1H1	8.63e-05	549	141	10	38280479
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	CABLES2 TTF2 TEP1 DYNC1H1	8.65e-05	57	141	4	27433848
Pubmed	Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus.	L1CAM LPA	9.74e-05	4	141	2	34380733
Pubmed	Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.	CYP4F8 CYP4F12	9.74e-05	4	141	2	22665481
Pubmed	Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.	CYP4F8 CYP4F12	9.74e-05	4	141	2	11185557
Pubmed	GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.	GATA2 NRP2	9.74e-05	4	141	2	23892628
Pubmed	RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.	RASGRP1 THBS1	9.74e-05	4	141	2	10087292
Pubmed	Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.	S1PR3 LPAR2	9.74e-05	4	141	2	10818441
Pubmed	Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis.	PIWIL1 RNF8	9.74e-05	4	141	2	28552346
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	GPC1 MFHAS1 EIF4A3 USP9X ZC3H13 GATA2 WAC LRPPRC OSBPL1A DOCK7 CTNND1 LTBP4 SDCBP	1.02e-04	922	141	13	27609421
Pubmed	A genome-wide association study identifies protein quantitative trait loci (pQTLs).	KIRREL3 ANGPTL6 LPA OSBPL1A	1.13e-04	61	141	4	18464913
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	PTBP3 EXOSC10 RBM12B EIF4A3 ZC3H13 CPEB3 LRPPRC OTUD4 PRKDC SPEN DYNC1H1 SON	1.17e-04	807	141	12	22681889
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	HECTD3 USP9X MCM7 DDB1 NUP205 IGF2R PRKDC CEP97 SDCBP DYNC1H1	1.19e-04	571	141	10	37167062
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	PDE3A HDAC5 ZC3H13 LRPPRC PRKDC DYNC1H1	1.31e-04	190	141	6	15161933
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	MAP3K3 PTK6 TAOK2 IGF2R PIK3CD CYP4F12 PRKDC	1.40e-04	276	141	7	28319085
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	ALX3 IGF2R ARID5B	1.41e-04	25	141	3	29475039
Pubmed	PIDD orchestrates translesion DNA synthesis in response to UV irradiation.	MCM7 DDB1 PRKDC	1.41e-04	25	141	3	21415862
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	GPC1 CABLES2 EXOSC10 HDAC5 PPP2R2D USP9X THBS1 LPA OTUD4	1.46e-04	475	141	9	31040226
Pubmed	Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.	CYP4F8 CYP4F12	1.62e-04	5	141	2	22969154
Pubmed	Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain.	L1CAM NRP2	1.62e-04	5	141	2	36963389
Pubmed	Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.	CYP4F8 CYP4F12	1.62e-04	5	141	2	21466787
Pubmed	Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.	IGF2R LPA	1.62e-04	5	141	2	21273553
Pubmed	Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells.	THBS1 LPA	1.62e-04	5	141	2	17431190
Pubmed	SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.	GATA2 SON	1.62e-04	5	141	2	23322776
Pubmed	The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters.	IGF2R LPA	1.62e-04	5	141	2	8854860
Pubmed	Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling.	APLP1 MED12	1.62e-04	5	141	2	21293490
Pubmed	Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.	ITGA2B PIK3CD	1.62e-04	5	141	2	19940148
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE3A PDE3B PIK3CD	1.78e-04	27	141	3	11156964
Pubmed	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.	EGLN1 NRP2 THBS1	1.78e-04	27	141	3	24586749
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	DDB1 NUP205 PRKDC DYNC1H1 SON	1.81e-04	128	141	5	23858473
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	GBE1 MSTO1 LRPPRC NDRG1 ASL MED12 SDCBP	1.82e-04	288	141	7	38496616
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	TPP2 PTBP3 TTF2 EXOSC10 LEO1 EIF4A3 USP9X ZC3H13 MCM7 LRRC7 PRKDC DYNC1H1	1.82e-04	847	141	12	35235311
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	TTF2 EXOSC10 EIF4A3 USP9X MCM7 DDB1 NUP205 LRPPRC WDR11 SLC25A10 NUB1 PRKDC CTNND1 MED12 DYNC1H1	1.88e-04	1257	141	15	37317656
Pubmed	TopBP1 controls BLM protein level to maintain genome stability.	USP9X MCM7 DDB1	2.21e-04	29	141	3	24239288
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	DLGAP1 LRRC7 CTNND1	2.21e-04	29	141	3	19208628
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	TPP2 EXOSC10 ACACB USP9X DDB1 MYPOP PRKDC SPEN	2.24e-04	396	141	8	26687479
Interaction	ARRDC3 interactions	TRIM42 EIF4A3 USP9X MCM7 MAGI2 WDR11 HECW2 DOCK7 CTNND1 SPEN SDCBP	5.19e-07	224	141	11	int:ARRDC3
Interaction	ITGB3 interactions	MAN2C1 MYO10 USP9X ITGA2B THBS1 DIAPH1 PRKDC DYNC1H1 SON	3.16e-06	170	141	9	int:ITGB3
Interaction	KIFAP3 interactions	MFHAS1 GBE1 MYPOP OSBPL1A CTNND1 MOS SON	1.39e-05	112	141	7	int:KIFAP3
Cytoband	8q11	PRKDC MOS	1.39e-04	6	141	2	8q11
GeneFamily	Mannosidases alpha class 2	MAN2C1 MAN2B2	2.70e-04	5	95	2	1194
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PKD1L2 ATRNL1 PKD1	1.30e-03	41	95	3	1298
GeneFamily	Fibronectin type III domain containing	COL12A1 TRIM42 L1CAM ASTN1 USH2A	1.56e-03	160	95	5	555
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1D DLGAP1 MYO10 S1PR3 THBS1 PIEZO2 SCN7A LRRN2	1.51e-07	187	141	8	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 OLFML3 PIEZO2 ATRNL1	1.71e-07	190	141	8	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 OLFML3 PIEZO2 ATRNL1	1.71e-07	190	141	8	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	1.78e-07	191	141	8	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	1.85e-07	192	141	8	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	1.85e-07	192	141	8	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE3A ABCC9 OLFML3 NRP2 PIEZO2 SCN7A LTBP4 SDCBP	1.85e-07	192	141	8	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1D S1PR3 OLFML3 NRP2 PIEZO2 HECW2 SCN7A LTBP4	1.93e-07	193	141	8	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	PDE3B USP9X LRPPRC IGF2R PRKDC CEP97 DYNC1H1 SON	1.93e-07	193	141	8	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 THBS1 PIEZO2 ATRNL1	2.01e-07	194	141	8	240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 THBS1 PIEZO2 ATRNL1	2.01e-07	194	141	8	ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 PDE3A MAGI2 THBS1 PIEZO2 LRRC7 LTBP4	2.01e-07	194	141	8	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 THBS1 PIEZO2 ATRNL1	2.09e-07	195	141	8	44d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	2.17e-07	196	141	8	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	2.17e-07	196	141	8	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	PDE3A COL12A1 S1PR3 OLFML3 ST6GAL2 ANGPTL6 SCN7A LTBP4	2.34e-07	198	141	8	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 PDE3B L1CAM GATA2 SYT16 THBS1 APCDD1L LRRN2	2.44e-07	199	141	8	3cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ABCC9 S1PR3 ST6GAL2 THBS1 PIEZO2 ATRNL1	1.76e-06	180	141	7	280ff5c8f292be1b88120db5ff1788b750644856
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ABCC9 S1PR3 ST6GAL2 THBS1 PIEZO2 ATRNL1	1.76e-06	180	141	7	fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL12A1 ABCC9 GPR88 OLFML3 PIEZO2 SCN7A LTBP4	1.89e-06	182	141	7	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	GPC1 COL10A1 COL12A1 OLFML3 CILP2 PIEZO2 APCDD1L	2.03e-06	184	141	7	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 PDE3B L1CAM GATA2 SYT16 THBS1 APCDD1L	2.18e-06	186	141	7	b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|Mesenchymal_cells / Lineage and Cell class	GPC1 ABCC9 OLFML3 NRP2 TFR2 FAM20C CTSW	2.26e-06	187	141	7	e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIZ L1CAM GATA2 RASGRP1 NDRG1 APCDD1L DOCK7	2.43e-06	189	141	7	3a295c215b5c18e7c673f92b7af5be523421682c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 PDE3B MFHAS1 SYT16 RASGRP1 APCDD1L DOCK7	2.51e-06	190	141	7	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CACNA1D PDE3A OLFML3 NRP2 PIEZO2 SCN7A ASTN1	2.60e-06	191	141	7	fa380a8752de158974b2ae5e741573439719cc0d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ABCC9 S1PR3 ST6GAL2 THBS1 PIEZO2 ATRNL1	2.69e-06	192	141	7	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 PDE3A MAGI2 THBS1 PIEZO2 LTBP4	2.69e-06	192	141	7	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 PDE3A MAGI2 THBS1 PIEZO2 LTBP4	2.69e-06	192	141	7	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	CACNA1D PDE3B COL10A1 MYO10 NRP2 PIEZO2 SCN7A	2.69e-06	192	141	7	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE3A ABCC9 OLFML3 NRP2 PIEZO2 SCN7A SDCBP	2.79e-06	193	141	7	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE3A ABCC9 OLFML3 NRP2 PIEZO2 SCN7A SDCBP	2.79e-06	193	141	7	96c85b250d04b5f400512097d925061c6dc2906b
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	CACNA1D DLGAP1 PDE3B MYO10 NRP2 PIEZO2 SCN7A	2.79e-06	193	141	7	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL12A1 GPR88 OLFML3 NRP2 SCN7A ARID5B LTBP4	2.89e-06	194	141	7	e2db75f4de114631b8bda4e188f84446545538b7
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1D DLGAP1 PDE3B MYO10 MAGI2 PIEZO2 SCN7A	2.89e-06	194	141	7	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PLVAP GATA2 DCBLD1 PIEZO2 HECW2 SCN7A	2.89e-06	194	141	7	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1D S1PR3 OLFML3 NRP2 PIEZO2 SCN7A LTBP4	2.89e-06	194	141	7	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE3A COL12A1 ABCC9 IFIT3 S1PR3 PIEZO2 HECW2	2.89e-06	194	141	7	78dcb9d48259afabe73b41c5508a73a8d62339a4
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CACNA1D PDE3A OLFML3 NRP2 MAGI2 PIEZO2 SCN7A	2.89e-06	194	141	7	8c37bedb23285735ff3828db3889897fada8c95d
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 PDE3A MAGI2 THBS1 PIEZO2 LTBP4	2.89e-06	194	141	7	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 THBS1 ATRNL1	2.99e-06	195	141	7	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	2.99e-06	195	141	7	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 ABCC9 S1PR3 THBS1 ATRNL1 LTBP4	2.99e-06	195	141	7	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 ABCC9 S1PR3 THBS1 ATRNL1 LTBP4	2.99e-06	195	141	7	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PLVAP GATA2 DUOX2 TAOK2 PIEZO2 HECW2	2.99e-06	195	141	7	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D MYO10 USP9X APLP1 DDB1 DYNC1H1 SON	2.99e-06	195	141	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 THBS1 ATRNL1	3.09e-06	196	141	7	ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A COL12A1 ABCC9 S1PR3 THBS1 ATRNL1	3.09e-06	196	141	7	30ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 DCBLD1 RALGAPA2 NRP2 NDRG1 HECW2 LTBP4	3.19e-06	197	141	7	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1D MYO10 OLFML3 PIEZO2 SCN7A ARID5B LTBP4	3.19e-06	197	141	7	31a1852911bda38543916585fda34255fd62a134
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	3.19e-06	197	141	7	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 DCBLD1 RALGAPA2 NRP2 NDRG1 HECW2 LTBP4	3.19e-06	197	141	7	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	3.19e-06	197	141	7	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A ABCC9 S1PR3 PIEZO2 ATRNL1 LTBP4	3.19e-06	197	141	7	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE3A ABCC9 GPR88 OLFML3 NRP2 PIEZO2 SCN7A	3.30e-06	198	141	7	12cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 DCBLD1 RALGAPA2 NRP2 NDRG1 HECW2 LTBP4	3.30e-06	198	141	7	f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GBE1 NT5DC3 NRP2 TFR2 FAM20C NDRG1 ASL	3.41e-06	199	141	7	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1D DLGAP1 SYT16 HECW2 ATRNL1 PKD1 LRRC7	3.53e-06	200	141	7	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	normal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	ALX3 ITGA2B TDRD1 CNNM1 CYP4F12 CTSW	1.01e-05	155	141	6	08295584395e8d9cfc1b1648f98754b3ac53e587
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MFHAS1 DCBLD1 GAL3ST4 TDRD1 PIEZO2 SPIC	1.50e-05	166	141	6	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 RADIL SCN7A LRRC7 LTBP4	1.77e-05	171	141	6	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	Tuft-tuft-4\|World / Class top	CABLES2 DCBLD1 NT5DC3 IFIT3 ST6GAL2 KIRREL3	1.95e-05	174	141	6	d6f306ebf66061bf9e9742000bfedce12d277452
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 S1PR3 PIEZO2 HECW2 OSBPL1A	2.02e-05	175	141	6	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLVAP GATA2 MCM7 PIEZO2 HECW2 SCN7A	2.08e-05	176	141	6	269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CALHM2 NRP2 RADIL PIEZO2 HECW2 MAP4K2	2.08e-05	176	141	6	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 ABCC9 PIEZO2 ATRNL1 LTBP4	2.22e-05	178	141	6	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	PDE3A COL12A1 NRP2 MAGI2 KIRREL3 ATRNL1	2.29e-05	179	141	6	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 GAL3ST4 ABCC9 S1PR3 OLFML3 LTBP4	2.36e-05	180	141	6	ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 PDE3A MAGI2 PIEZO2 LRRC7	2.36e-05	180	141	6	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 PDE3A S1PR3 MAGI2 PIEZO2	2.36e-05	180	141	6	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	COVID-19-Heart-Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A DCBLD1 ABCC9 S1PR3 SCN7A ASTN1	2.44e-05	181	141	6	33cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 GATA2 RASGRP1 TRPM5 NDRG1 DOCK7	2.44e-05	181	141	6	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D GALNT10 PDE3A MFHAS1 MAGI2 SCN7A	2.44e-05	181	141	6	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 ABCC9 THBS1 ATRNL1 LTBP4	2.52e-05	182	141	6	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A COL12A1 ABCC9 THBS1 ATRNL1 LTBP4	2.52e-05	182	141	6	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA2 APLP1 PIEZO2 TRPM5 HECW2 ASTN1	2.52e-05	182	141	6	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|World / Stress and Cell class	GPC1 OLFML3 FAM20C THBS1 PKD1 LTBP4	2.67e-05	184	141	6	684d05340a3dfb8aa08b881516a37f9627a10448
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 KIZ GATA2 NDRG1 APCDD1L DOCK7	2.76e-05	185	141	6	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP GATA2 THBS1 PIEZO2 HECW2 LTBP4	2.76e-05	185	141	6	512a195ebbae445afe3722a3943020080daf2f3c
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DLGAP1 PDE3A KIZ NRP2 SCN7A LTBP4	2.76e-05	185	141	6	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	S1PR3 OLFML3 NRP2 SCN7A LRRC7 LTBP4	2.76e-05	185	141	6	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	droplet-Bladder-Unstain-18m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP ABCC9 APLP1 S1PR3 NRP2 HECW2	2.84e-05	186	141	6	e3a14f3ccadbf3211822c67b8956ee01f563307a
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	GALNT10 PDE3B COL12A1 KIRREL3 SCN7A LTBP4	2.93e-05	187	141	6	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	E17.5-Endothelial-unknown_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLVAP GATA2 DCBLD1 PIEZO2 HECW2 SCN7A	2.93e-05	187	141	6	da885c26ccc5189b1ff1f607552e00a5c0e49e7e
ToppCell	E17.5-Endothelial-unknown_endothelial_cell-endothelial_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLVAP GATA2 DCBLD1 PIEZO2 HECW2 SCN7A	2.93e-05	187	141	6	1f358d02ec69d44dea2e2831af9473ed05dcf8cc
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B KIZ GATA2 RASGRP1 NDRG1 APCDD1L	2.93e-05	187	141	6	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 KIZ GATA2 NDRG1 APCDD1L DOCK7	2.93e-05	187	141	6	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	facs-Pancreas-Endocrine-3m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP ABCC9 NRP2 PIEZO2 HECW2 LTBP4	3.02e-05	188	141	6	da862ea3c74f42d0dbae38b09211a45c593d477e
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DLGAP1 PIWIL1 L1CAM TFR2 SCN7A LRRN2	3.02e-05	188	141	6	502045a39ffb1e92bd9499848368e8fa971edb88
ToppCell	facs-Pancreas-Endocrine-3m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP ABCC9 NRP2 PIEZO2 HECW2 LTBP4	3.02e-05	188	141	6	b82a7667ef74a05e8bc744f6c090a7cc7b8efe32
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 PDE3B RASGRP1 APCDD1L DOCK7 LRRN2	3.02e-05	188	141	6	4154f4787483c7e076e87a187733a9f666742c3d
ToppCell	facs-Pancreas-Endocrine-3m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP ABCC9 NRP2 PIEZO2 HECW2 LTBP4	3.02e-05	188	141	6	19672d284fe89c9c3c7697514ca1f659329c34f4
ToppCell	PND07-28-samps-Endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PDE3A PLVAP MYO10 GATA2 PIEZO2 SCN7A	3.11e-05	189	141	6	eb2f8c8a90e5e9f6697a2d13274c94f40e1973e4
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 S1PR3 THBS1 PIEZO2 LTBP4	3.11e-05	189	141	6	e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 MFHAS1 RASGRP1 APCDD1L DOCK7 LRRN2	3.11e-05	189	141	6	90aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1D DLGAP1 MYO10 MAGI2 PIEZO2 SCN7A	3.11e-05	189	141	6	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 KIZ GATA2 RASGRP1 FAM20C NDRG1	3.11e-05	189	141	6	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D DLGAP1 MYO10 THBS1 PIEZO2 LTBP4	3.11e-05	189	141	6	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE3A ABCC9 S1PR3 NRP2 ATRNL1	3.11e-05	189	141	6	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PDE3A PLVAP MYO10 GATA2 PIEZO2 SCN7A	3.11e-05	189	141	6	d4a25d59d88325d3b20f4287e9b1160c82961a96
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	HDAC5 TEP1 CALHM2 THBS1 NDRG1 OTUD4 LTBP4 CEP97	1.88e-05	184	140	8	1007_UP
Drug	Quinacrine dihydrochloride dihydrate [6151-30-0]; Up 200; 7.8uM; MCF7; HT_HG-U133A	ALX3 GPC1 PDE3B CPEB3 TEP1 SIRT4 TAOK2 OSGIN1	2.55e-05	192	140	8	3179_UP
Drug	ICI 182,780; Down 200; 1uM; MCF7; HG-U133A	PTBP3 DLGAP1 RBM12B GAL3ST4 TDRD1 RASGRP1 THBS1 PIEZO2	2.55e-05	192	140	8	367_DN
Drug	Thonzonium bromide [553-08-2]; Up 200; 6.8uM; MCF7; HT_HG-U133A	CHST5 PLVAP RNPEPL1 APLP1 ITGA2B CHRNE PTK6 ATRNL1	2.75e-05	194	140	8	6457_UP
Drug	estradiol, USP; Down 200; 0.1uM; MCF7; HT_HG-U133A	HDAC5 MYO10 GATA2 ITGA2B TEP1 EXD3 LTBP4 OSGIN1	2.96e-05	196	140	8	5568_DN
Drug	Inocor (TN)	PDE3A PDE3B	3.75e-05	2	140	2	CID000656683
Drug	RS-1893	PDE3A PDE3B	3.75e-05	2	140	2	CID000128386
Drug	C12063	DLGAP1 PLVAP MAN2C1 MAN2B2 APLP1 TEP1 IFIT3 IGF2R NDRG1 MAP4K2 RAD23A	7.19e-05	429	140	11	CID005282055
Drug	anagrelide	PDE3A PLVAP ITGA2B IFIT3	8.59e-05	38	140	4	CID000002182
Drug	SureCN4406168	PDE3A PDE3B	1.12e-04	3	140	2	CID011502028
Drug	(3S,4S)-pyrrolidine-3,4-diol	MAN2C1 MAN2B2	1.12e-04	3	140	2	CID000146198
Drug	SureCN4395097	PDE3A PDE3B	1.12e-04	3	140	2	CID011610011
Drug	SureCN4401117	PDE3A PDE3B	1.12e-04	3	140	2	CID011718172
Drug	SureCN4402206	PDE3A PDE3B	1.12e-04	3	140	2	CID011516917
Drug	WIN 62582	PDE3A PDE3B	1.12e-04	3	140	2	CID005487388
Drug	(1R,2R,3S,4R)-4-aminocyclopentane-1,2,3-triol	MAN2C1 MAN2B2	1.12e-04	3	140	2	CID010034676
Drug	SureCN4397066	PDE3A PDE3B	1.12e-04	3	140	2	CID011538627
Drug	SureCN4401121	PDE3A PDE3B	1.12e-04	3	140	2	CID011611819
Drug	Man)6(GlcNAc)2Asn	MAN2C1 MAN2B2	1.12e-04	3	140	2	CID000170160
Drug	SureCN4404748	PDE3A PDE3B	1.12e-04	3	140	2	CID011502895
Drug	SureCN4411688	PDE3A PDE3B	1.12e-04	3	140	2	CID011523192
Drug	oligostatin C	MAN2C1 MAN2B2	1.12e-04	3	140	2	CID000174107
Drug	SureCN4405038	PDE3A PDE3B	1.12e-04	3	140	2	CID011546172
Drug	SureCN4405912	PDE3A PDE3B	1.12e-04	3	140	2	CID011682920
Drug	pelrinone	PDE3A PDE3B	1.12e-04	3	140	2	CID000055919
Drug	SureCN4398032	PDE3A PDE3B	1.12e-04	3	140	2	CID011532088
Drug	methyl oligobiosaminide	MAN2C1 MAN2B2	1.12e-04	3	140	2	CID003083102
Drug	SureCN4406373	PDE3A PDE3B	1.12e-04	3	140	2	CID011711104
Drug	SureCN4394894	PDE3A PDE3B	1.12e-04	3	140	2	CID011711103
Drug	SureCN5995113	PDE3A PDE3B	1.12e-04	3	140	2	CID011640499
Drug	CHEMBL219123	PDE3A PDE3B	1.12e-04	3	140	2	CID016102624
Drug	germitrine	PDE3A PDE3B	1.12e-04	3	140	2	CID000011217
Drug	SureCN4411840	PDE3A PDE3B	1.12e-04	3	140	2	CID011567407
Drug	SureCN4401113	PDE3A PDE3B	1.12e-04	3	140	2	CID011544858
Drug	SureCN4405883	PDE3A PDE3B	1.12e-04	3	140	2	CID011516351
Drug	SureCN4407211	PDE3A PDE3B	1.12e-04	3	140	2	CID011553351
Drug	SureCN4401096	PDE3A PDE3B	1.12e-04	3	140	2	CID011710801
Drug	p-Nitrophenyl alpha-D-xyloside	GPC1 COL10A1 SLC25A10 SDCBP	1.16e-04	41	140	4	CID000082482
Disease	prothrombin measurement	TTF2 CSTPP1	1.28e-04	4	137	2	EFO_0020692
Disease	platelet crit	EIF4A3 RNPEPL1 GATA2 RNF8 ITGA2B CHRNE TFR2 NUP205 THBS1 LPA ARID5B OTUD4 LRRN2 OSGIN1	1.44e-04	952	137	14	EFO_0007985
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	GALNTL6 ACACB MFHAS1 IGF2R LPA DOCK7 MAP4K2	3.04e-04	274	137	7	EFO_0004530, EFO_0004612
Disease	peripheral neuropathy	GALNTL6 SCN7A	4.43e-04	7	137	2	EFO_0003100
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	PDE3A MFHAS1 MYPOP IGF2R LPA DOCK7	6.14e-04	222	137	6	EFO_0008317, EFO_0020943
Disease	cholesteryl esters to total lipids in medium LDL percentage	IGF2R LPA DOCK7	6.78e-04	37	137	3	EFO_0022252
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	ACACB MFHAS1 LPA DOCK7	7.03e-04	86	137	4	EFO_0008595, EFO_0020945
Disease	Endomyocardial Fibrosis	SIRT4 IGF2R	7.54e-04	9	137	2	C0553980
Disease	sleep duration, low density lipoprotein cholesterol measurement	MAGI2 IGF2R LPA DOCK7	8.69e-04	91	137	4	EFO_0004611, EFO_0005271
Disease	fatty acid measurement	ACACB MFHAS1 MYO10 IGF2R LPA DOCK7 NUB1 MAP4K2	1.01e-03	436	137	8	EFO_0005110
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	ACACB IGF2R LPA DOCK7 MAP4K2	1.09e-03	166	137	5	EFO_0004530, EFO_0004611
Disease	complement factor H-related protein 3 measurement	COL12A1 GBE1 NUP205 ARID5B USH2A	1.18e-03	169	137	5	EFO_0600056
Disease	Adenoid Cystic Carcinoma	MAGI2 ARID5B PRKDC SON	1.24e-03	100	137	4	C0010606
Disease	monocyte count	TTF2 PLVAP TDRD1 S1PR3 CILP2 PIK3CD LPA ASL PKD1 DIAPH1 NUB1 PRKDC CTSW SDCBP SPIC	1.25e-03	1320	137	15	EFO_0005091
Disease	familial hyperlipidemia	CILP2 IGF2R LPA DOCK7	1.53e-03	106	137	4	MONDO_0001336
Disease	Connective Tissue Diseases	PIEZO2 PKD1	1.61e-03	13	137	2	C0009782
Disease	complex trait	DCBLD1 IP6K1 TAOK2 LPA DOCK7 MAP4K2	1.71e-03	271	137	6	EFO_0010578
Disease	phospholipids in medium VLDL measurement	IGF2R LPA DOCK7	1.83e-03	52	137	3	EFO_0022154
Disease	total cholesterol measurement, low density lipoprotein cholesterol measurement	TFR2 IGF2R LPA DOCK7	2.00e-03	114	137	4	EFO_0004574, EFO_0004611
Disease	total lipids in medium VLDL	IGF2R LPA DOCK7	2.04e-03	54	137	3	EFO_0022153
Disease	Acute Cerebrovascular Accidents	PDE3A ITGA2B LPA	2.04e-03	54	137	3	C0751956
Disease	triglycerides in LDL measurement	IGF2R LPA DOCK7	2.27e-03	56	137	3	EFO_0022320
Disease	transferrin saturation measurement	DUOX2 TFR2	2.46e-03	16	137	2	EFO_0006333
Disease	phospholipids in VLDL measurement	IGF2R LPA DOCK7	2.63e-03	59	137	3	EFO_0022301
Disease	total lipids in VLDL measurement	IGF2R LPA DOCK7	2.76e-03	60	137	3	EFO_0022314
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	ACACB IGF2R LPA DOCK7 MAP4K2	2.80e-03	206	137	5	EFO_0004612, EFO_0020947
Disease	cholesteryl ester measurement, low density lipoprotein cholesterol measurement	TFR2 IGF2R LPA DOCK7	2.87e-03	126	137	4	EFO_0004611, EFO_0010351
Disease	pancreatic ductal carcinoma (is_marker_for)	L1CAM MCM7 THBS1	2.89e-03	61	137	3	DOID:3587 (is_marker_for)
Disease	free cholesterol in VLDL measurement	IGF2R LPA DOCK7	2.89e-03	61	137	3	EFO_0022276
Disease	Cerebrovascular accident	PDE3A ITGA2B LPA	3.03e-03	62	137	3	C0038454
Disease	triglycerides in medium LDL measurement	IGF2R LPA DOCK7	3.03e-03	62	137	3	EFO_0022322
Disease	cholesterol in large VLDL measurement	IGF2R LPA DOCK7	3.47e-03	65	137	3	EFO_0021902
Disease	cholesterol in very large VLDL measurement	IGF2R LPA DOCK7	3.47e-03	65	137	3	EFO_0022230
Disease	diet measurement	TTF2 PPP2R2D MFHAS1 GBE1 RALGAPA2 PTK6 MAGI2 KIRREL3 HECW2 LPA LRRN2 PRKDC	3.64e-03	1049	137	12	EFO_0008111
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	ACACB IGF2R LPA DOCK7 MAP4K2	4.01e-03	224	137	5	EFO_0004530, EFO_0008317
Disease	ascending aortic diameter	GATA2 ABCC9 PIEZO2 ARID5B	4.19e-03	140	137	4	EFO_0021787
Disease	Arthrogryposis	L1CAM DYNC1H1	4.24e-03	21	137	2	C0003886

Protein segments in the cluster

Peptide	Gene	Start	Entry
YGNEEIIPLNRIYHL	TDRD1	351	Q9BXT4
TDLYHLPENFRPYTN	CEP152	141	O94986
HYPDVYAREQLALRT	ALX3	176	O95076
IYELSYAREPRNHRA	RASGRP1	426	O95267
TDPAERRHYRPTGYQ	APCDD1L	226	Q8NCL9
RELQRHGYENPTYRF	APLP1	631	P51693
ENKSRPHSRGEYNVY	PPP2R2D	66	Q66LE6
QFERQLPLSRDGYHT	DLGAP1	106	O14490
TINRKQPGRYHLDSY	ABCC9	641	O60706
QPGRYHLDSYEQSTR	ABCC9	646	O60706
RLRGQYFPHNYKQLE	DNHD1	666	Q96M86
HLLLVRNDYEARPQY	DIAPH1	416	O60610
GQRRNYAHALDGLYR	SLC25A10	136	Q9UBX3
LGSPTLHRVLYHYNQ	ASTN1	1191	O14525
RLYHHLFNNYDPGSR	CHRNE	26	Q04844
HGYRIIPDSVSIQYN	RBM12B	946	Q8IXT5
ASYNNPHRAVEYLLT	RAD23A	186	P54725
RDEGYQYHRNVRGRP	OTUD4	1081	Q01804
AHASLRYNPRERQLY	OLFML3	371	Q9NRN5
VVNIARYLYHGNTNP	NUP205	896	Q92621
RYLYHGNTNPELAFE	NUP205	901	Q92621
LIYDGIHYDPLQRNF	YOD1	261	Q5VVQ6
PNVVAYIGSYLRNDR	MAP4K2	71	Q12851
RLYLLQGIRNYHSGN	NUB1	341	Q9Y5A7
ALERYALDPRQAGQY	RADIL	96	Q96JH8
YIAYELNSLQHRQLP	ACACB	1301	O00763
YNLGRRLPADHVSGY	HECW2	301	Q9P2P5
HQRGLSASYLEPDRY	LEO1	561	Q8WVC0
PATYQALYQRRHTAG	GPR88	146	Q9GZN0
DYRQHSPDTRQYPLS	MAGI2	1121	Q86UL8
SNRRFHQPIYYLLGN	LPAR2	56	Q9HBW0
PHAAYYGVSDKNLRR	MFHAS1	591	Q9Y4C4
PYLRPLTLHYRQNGA	NUDT14	16	O95848
LKRNGRYEDEHPSYQ	LRRC7	1166	Q96NW7
SELRLYYRGANLHLE	GPC1	146	P35052
YQRRPEYRHLSAGDV	GALNT10	406	Q86SR1
LYLNHNQLYRIAPRA	LRRN2	146	O75325
RDVLFPGYTHLQRAQ	ASL	151	P04424
NYDLPNNRELYIHRI	EIF4A3	351	P38919
RQYEGHVNESAYLPL	DCAF4L1	306	Q3SXM0
RLQRRVPANYADGVY	DUOX2	56	Q9NRD8
LYRENQGLPLYSRLH	CALHM2	286	Q9HA72
RTLAHNNGLYSPVYL	CCNYL2	301	Q5T2Q4
IPRSLDNLGYNLYHP	PLVAP	246	Q9BX97
LYENRNNRTRYGDPI	MMP21	366	Q8N119
GPYHRGEAQRNIYRL	MSTO1	266	Q9BUK6
ALEIGYRDIPYHNRI	PDE3A	741	Q14432
ALENGYRDIPYHNRI	PDE3B	726	Q13370
PGNLHLFINAYNSRR	NDRG1	221	Q92597
LALYFSRHQVRGQPD	NRP2	11	O60462
VRQNPGERNYHIFYA	MYO10	251	Q9HD67
NIYRGIRNLLESYHV	LRPPRC	621	P42704
ARNRHGLLLANAYIY	L1CAM	406	P32004
TLGVLYDQPRHVQYA	MED12	721	Q93074
LSSPDYYERLGQLQH	KIZ	11	Q2M2Z5
YRKQPDAVHNIYRQG	OSBPL1A	266	Q9BXW6
EQHSARAPLLDYIYR	RALGAPA2	1286	Q2PPJ7
YRPGARGDHYARNLL	GAL3ST4	196	Q96RP7
AYGRYNPRRSLEQNI	MCM7	491	P33993
YGQRDPSAYHLNRHL	PKD1L2	1966	Q7Z442
AVAQGYVPHNYLAER	PTK6	56	Q13882
GNPYYANPAHARARV	GATA2	56	P23769
ARREDESYGYVLPNH	EXOSC10	521	Q01780
FPRKGNNESYHYARR	GBE1	551	Q04446
LYDFTETHNQRGRPI	DOCK7	1256	Q96N67
RLALPDYEYLAQRHV	CSTPP1	6	Q9H6J7
YAQRSAAAAYGHQPI	CPEB3	201	Q8NE35
DHADGPVQQYRIIYS	COL12A1	2046	Q99715
IGINRYELYSRHNPA	FAM20C	231	Q8IXL6
RAYRPGQHIQLVQYL	CEP97	256	Q8IW35
LYNLARHPEYQERCR	CYP4F8	341	P98187
LYNLARHPEYQERCR	CYP4F12	341	Q9HCS2
RVLESTPNNGYLYHQ	IFIT3	266	O14879
NEHRIAQYLATYGPI	CTSW	246	P56202
LEPESDHYRLRLGQY	ANGPTL6	366	Q8NI99
HQRTTEYYPNGGLTR	LPA	1306	P08519
GPLQRYGHSLALYQE	ATRNL1	351	Q5VV63
RNPHEVQPAYATRYA	EGLN1	371	Q9GZT9
SYRHYNIRPTAGAQE	MAN2B2	536	Q9Y2E5
YEIQFGHLQRPTHYN	MAN2C1	826	Q9NTJ4
HYSASDLRYNTRPLG	LTBP4	466	Q8N2S1
NALYQYLHNGLDLRR	IP6K1	291	Q92551
LPRIQSQRYQVGVHY	DYNC1H1	996	Q14204
RDLSSYPQYLVVGNH	KIRREL3	91	Q8IZU9
EYHTLLYGTSPLNRQ	HDAC5	746	Q9UQL6
DYQRPHSAQPADRGY	DCBLD1	651	Q8N8Z6
HDGNLYPRLYPELSQ	SDCBP	41	O00560
GELQAPGTYQRHYRN	SLC25A35	31	Q3KQZ1
PVRGNETLREHYQYV	S1PR3	11	Q99500
YLPENQVLPHYRRLT	CABLES2	461	Q9BTV7
IAYGLLLHPNAYVRN	CACNA1D	181	Q01668
LSYQVHREIPQAERY	CTNND1	586	O60716
AVGRALYYLQIHPQE	DDB1	511	Q16531
YVPERQQHIARQGSY	MAP3K3	181	Q99759
SAADAVLYARHYNIP	OSGIN1	296	Q9UJX0
EHSYLRPGDYRVQVN	PKD1	2111	P98161
QAPYSGERQHILYAV	MOS	276	P00540
IHREPNLSLSNRLYY	PIWIL1	846	Q96J94
YQRRPEYRHLSTGDI	GALNTL6	401	Q49A17
QLNYRGGTPYNNERH	IGF2R	706	P11717
PNGIISHYRVVYQER	USH2A	3991	O75445
DYDPQTVRLGSRYSH	USP9X	636	Q93008
LQIVVRNDYYPDLHR	RNPEPL1	606	Q9HAU8
YRPDPQLRLHSINYV	TRIM42	461	Q8IWZ5
RLEPLRVYSIHQGDY	RNF8	91	O76064
HFRNLAVNRAPDTYG	SYT16	531	Q17RD7
LHLRSYTVPQEQRYI	TMEM184A	76	Q6ZMB5
YDPNFAIRGLHYDVQ	NT5DC3	141	Q86UY8
PDYNLFTPYIQHRQR	ST6GAL2	386	Q96JF0
QHGDFVRSAPIRQRY	SIRT4	91	Q9Y6E7
PNTIQYRGCYLREHT	TAOK2	86	Q9UL54
HDRRGDSQPYQALKY	WAC	16	Q9BTA9
GAVEILDSYYQRLHR	ITGA2B	296	P08514
RQHSTGDLQYSPDYR	SPIC	21	Q8N5J4
SPDYRNYLALINHRP	SPIC	31	Q8N5J4
LNSRLPAGYSHSLQY	ARID5B	1091	Q14865
QPYLDRLGYRRTDHD	CILP2	836	Q8IUL8
QLLGYRPVYSADQQR	CHST5	376	Q9GZS9
YNRQQHYDPRTGIFT	COL10A1	576	Q03692
YTRIPVYEGDQRHNI	CNNM1	461	Q9NRU3
ELRRPPLCYHNGVQY	THBS1	311	P07996
LGQLHPELEQYRLYQ	TTC30B	71	Q8N4P2
HVQALLGYRYPSNLQ	TEP1	456	Q99973
QRYNLIVEYHERPAL	TRPM5	996	Q9NZQ8
RDPRERTLQHGLYYA	SPEN	171	Q96T58
QAIHNYLLSLYARGR	VPS18	661	Q9P253
HQEYYRGRNNLTAPV	PIEZO2	1076	Q9H5I5
NYLPLYVARLHQLDA	TPP2	1051	P29144
PEDYTLQVNGRHEYL	PIK3CD	236	O00329
LRSQPVYIQYSNHRE	PTBP3	121	O95758
LYRSYRHGDLPDIQI	PRKDC	2771	P78527
LGQLHPELEQYRLYQ	TTC30A	71	Q86WT1
NPLQYYLLGEDAHRA	TSPYL6	376	Q8N831
NETLHNRTGNPYYIR	SCN7A	276	Q01118
DHYYSRQRGRRNPSP	ZRSR2P1	376	Q15695
RENYHHNIGSPYCLR	WDR11	71	Q9BZH6
VYAHYGRPEDLQDLR	TFR2	246	Q9UP52
PYYDVSRNARHADGV	VIP	71	P01282
RLGHDAYRLGQDPYR	SON	936	P18583
LYRHQRLHTGERPYE	ZNF449	366	Q6P9G9
TYPEESRSYGRNHLR	ZC3H13	521	Q5T200
SNKLRVYLYHGPNRD	TTF2	666	Q9UNY4
YSHRLGSRPQPAEAY	HECTD3	186	Q5T447
AVEPDRYVLYGNHRD	NAALADL1	356	Q9UQQ1
DRYYQLPIPRENVHL	EXD3	361	Q8N9H8
EVRAHYPQLYGAQSR	MYPOP	31	Q86VE0