Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 SPTAN1 ACTN2 SCGN LPCAT2 USP32 PCDHGB4 PLCH1 CDH8 NIN	6.34e-05	749	110	14	GO:0005509
GeneOntologyMolecularFunction	deubiquitinase activity	USP9X PRPF8 USP19 ZUP1 USP32 USP27X	6.42e-05	124	110	6	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP9X PRPF8 USP19 ZUP1 USP32 USP27X	1.12e-04	137	110	6	GO:0019783
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP9X USP19 USP27X	2.01e-04	21	110	3	GO:1990380
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP9X USP19 ZUP1 USP32 USP27X	4.22e-04	114	110	5	GO:0004843
GeneOntologyCellularComponent	distal axon	PCDHGB1 USP9X RAPGEF4 GRIK3 SCGN NEFL RIMBP2 CDH8 FKBP4 NIN	1.01e-04	435	110	10	GO:0150034
Domain	Cadherin_tail	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	7.29e-08	37	110	6	PF15974
Domain	Cadherin_CBD	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	7.29e-08	37	110	6	IPR031904
Domain	Cadherin_C	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.61e-07	42	110	6	IPR032455
Domain	Cadherin_C_2	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.61e-07	42	110	6	PF16492
Domain	Cadherin_2	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	2.27e-06	65	110	6	PF08266
Domain	Cadherin_N	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	2.27e-06	65	110	6	IPR013164
Domain	Cadherin_CS	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	3.69e-06	109	110	7	IPR020894
Domain	CADHERIN_1	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	4.69e-06	113	110	7	PS00232
Domain	Cadherin	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	4.69e-06	113	110	7	PF00028
Domain	CADHERIN_2	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	4.97e-06	114	110	7	PS50268
Domain	-	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	4.97e-06	114	110	7	2.60.40.60
Domain	CA	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	5.27e-06	115	110	7	SM00112
Domain	Cadherin-like	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	5.58e-06	116	110	7	IPR015919
Domain	Cadherin	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4 CDH8	6.25e-06	118	110	7	IPR002126
Domain	Spectrin	SPTAN1 ACTN2 SPTBN4	3.23e-04	23	110	3	PF00435
Domain	EFh	SPTAN1 ACTN2 SCGN LPCAT2 USP32 PLCH1	3.46e-04	158	110	6	SM00054
Domain	EF_HAND_2	SPTAN1 ACTN2 SCGN LPCAT2 USP32 PLCH1 NIN	4.37e-04	231	110	7	PS50222
Domain	EF_hand_dom	SPTAN1 ACTN2 SCGN LPCAT2 USP32 PLCH1 NIN	4.49e-04	232	110	7	IPR002048
Domain	EF-hand_Ca_insen	SPTAN1 ACTN2	5.08e-04	6	110	2	IPR014837
Domain	EFhand_Ca_insen	SPTAN1 ACTN2	5.08e-04	6	110	2	PF08726
Domain	USP_CS	USP9X USP19 USP32 USP27X	6.20e-04	66	110	4	IPR018200
Domain	Spectrin_repeat	SPTAN1 ACTN2 SPTBN4	6.50e-04	29	110	3	IPR002017
Domain	USP_1	USP9X USP19 USP32 USP27X	7.75e-04	70	110	4	PS00972
Domain	UCH	USP9X USP19 USP32 USP27X	8.17e-04	71	110	4	PF00443
Domain	USP_2	USP9X USP19 USP32 USP27X	8.17e-04	71	110	4	PS00973
Domain	USP_3	USP9X USP19 USP32 USP27X	8.61e-04	72	110	4	PS50235
Domain	USP_dom	USP9X USP19 USP32 USP27X	8.61e-04	72	110	4	IPR028889
Domain	Peptidase_C19_UCH	USP9X USP19 USP32 USP27X	8.61e-04	72	110	4	IPR001394
Domain	Spectrin/alpha-actinin	SPTAN1 ACTN2 SPTBN4	8.71e-04	32	110	3	IPR018159
Domain	SPEC	SPTAN1 ACTN2 SPTBN4	8.71e-04	32	110	3	SM00150
Domain	-	SPTAN1 ACTN2 SCGN LPCAT2 USP32 PLCH1 NIN	8.99e-04	261	110	7	1.10.238.10
Domain	EF-hand-dom_pair	SPTAN1 ACTN2 SCGN LPCAT2 USP32 PLCH1 NIN	1.56e-03	287	110	7	IPR011992
Domain	ABC_transporter_CS	ABCC1 ABCA2 ABCB9	1.93e-03	42	110	3	IPR017871
Domain	-	DNAJC13 USP9X CUL9 HEATR1 TRIP12 UTP20	2.02e-03	222	110	6	1.25.10.10
Domain	WWE	PARP14 TRIP12	2.18e-03	12	110	2	PS50918
Domain	WWE	PARP14 TRIP12	2.18e-03	12	110	2	PF02825
Domain	WWE-dom	PARP14 TRIP12	2.18e-03	12	110	2	IPR004170
Domain	ABC_tran	ABCC1 ABCA2 ABCB9	2.84e-03	48	110	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCC1 ABCA2 ABCB9	2.84e-03	48	110	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCC1 ABCA2 ABCB9	3.01e-03	49	110	3	PS00211
Domain	ABC_transporter-like	ABCC1 ABCA2 ABCB9	3.19e-03	50	110	3	IPR003439
Domain	EF_Hand_1_Ca_BS	SPTAN1 SCGN LPCAT2 USP32 PLCH1	3.78e-03	175	110	5	IPR018247
Domain	ARM-type_fold	DNAJC13 USP9X CUL9 APOB HEATR1 TRIP12 UTP20	3.94e-03	339	110	7	IPR016024
Domain	LRR_6	NLRX1 NRROS TONSL	4.17e-03	55	110	3	PF13516
Domain	A/G_cyclase_CS	ADCY6 GUCY1A2	4.41e-03	17	110	2	IPR018297
Domain	Nucleotide_cyclase	ADCY6 GUCY1A2	4.95e-03	18	110	2	IPR029787
Domain	-	ADCY6 GUCY1A2	4.95e-03	18	110	2	3.30.70.1230
Domain	ARM-like	DNAJC13 USP9X CUL9 HEATR1 TRIP12 UTP20	5.29e-03	270	110	6	IPR011989
Domain	GUANYLATE_CYCLASE_1	ADCY6 GUCY1A2	5.51e-03	19	110	2	PS00452
Domain	Guanylate_cyc	ADCY6 GUCY1A2	5.51e-03	19	110	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY6 GUCY1A2	5.51e-03	19	110	2	PS50125
Domain	A/G_cyclase	ADCY6 GUCY1A2	5.51e-03	19	110	2	IPR001054
Domain	CYCc	ADCY6 GUCY1A2	5.51e-03	19	110	2	SM00044
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	GPI DNAJC13 CYTH1 HEATR1 PRPF8 TRIP12 LARP7 ZC2HC1A PTCD1 EIF3L YLPM1 UTP3 PLCH1 TACSTD2 G6PD FKBP4 TRMT61A NIN	2.05e-11	732	111	18	34732716
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	XRN2 USP9X SPTAN1 CUL9 HEATR1 PRPF8 TRIP12 LARP7 NEFL EIF3L YLPM1 UTP20 NUP93 FKBP4 SEC23B	2.79e-09	653	111	15	22586326
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 SPTAN1 APOB HEATR1 ACTN2 PRPF8 TRIP12 ADCY6 LARP7 SPTBN4 NEFL ABCB9 GUCY1A2 GNA13 YLPM1 PCDHGB4 PLCH1	5.30e-09	1442	111	21	35575683
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GPI XRN2 NEDD4L RBM12B USP9X POLR2B HEATR1 PRPF8 TRIP12 NEFL SUMO1 GNA13 DHCR7 YLPM1 UTP20 NUP93 FKBP4	2.79e-08	1024	111	17	24711643
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	USP9X POLR2B RAPGEF4 MORC2 PRPF8 TRIP12 CAPN7 USP32 ASCC2 UTP3 G6PD WNK4	6.97e-08	497	111	12	36774506
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	8.59e-08	68	111	6	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.21e-07	72	111	6	10380929
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GPI XRN2 USP9X SPTAN1 POLR2B APOB HEATR1 PRPF8 USP19 DARS2 LARP7 SUMO1 DHCR7 EIF3L UTP20 NUP93 UTP3 G6PD FKBP4	1.24e-07	1425	111	19	30948266
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.43e-07	74	111	6	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.82e-07	77	111	6	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	2.29e-07	80	111	6	10716726
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	ABCC1 RBM12B RAPGEF4 CUL9 PRPF8 USP19 WDR20 TLR2 RIMBP2 SEC23B	3.35e-07	371	111	10	15747579
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	XRN2 DNAJC13 USP9X SPTAN1 POLR2B HEATR1 PRPF8 USP19 TUBGCP3 EIF3L NUP93 FKBP4	9.91e-07	638	111	12	33239621
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	GPI NEDD4L POLR2B MORC2 PRPF8 DARS2 LARP7 TUBGCP3 CFDP1 SEC23B	1.01e-06	419	111	10	28700943
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	XRN2 DNAJC13 NEDD4L RBM12B CYTH1 SPTAN1 POLR2B PRPF8 TRIP12 NEFL ZC2HC1A DHCR7 TUBGCP3 YLPM1 SEC23B	1.88e-06	1082	111	15	38697112
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DNAJC13 NEDD4L USP9X CYTH1 SPTAN1 RAPGEF4 ARHGEF12 GRIK3 SPTBN4 NEFL ZC2HC1A YLPM1 PRKAR1B RIMBP2	2.47e-06	963	111	14	28671696
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	NEDD4L PRPF8 TRIP12 USP19 GNA13 WDR20 TUBGCP3 EIF3L YLPM1 USP32 RIMBP2 NUP93 USP27X NIN	4.04e-06	1005	111	14	19615732
Pubmed	Defining the membrane proteome of NK cells.	GPI ABCC1 XRN2 ABCA2 DNAJC13 USP9X HEATR1 PARP14 PRPF8 GNA13 DHCR7 TUBGCP3 EIF3L NUP93 G6PD	4.76e-06	1168	111	15	19946888
Pubmed	Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer's Disease.	NEDD4L USP9X RIMBP2	5.12e-06	11	111	3	32140098
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	GPI XRN2 ENOX1 USP9X CYTH1 SPTAN1 POLR2B PRPF8 NEFL YLPM1 USP32 NUP93 SEC23B	8.05e-06	922	111	13	27609421
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP9X USP19 ZUP1 DARS2 USP32 USP27X	8.09e-06	147	111	6	29576527
Pubmed	Combined glucose-6-phosphate dehydrogenase and glucosephosphate isomerase deficiency can alter clinical outcome.	GPI G6PD	1.01e-05	2	111	2	12737943
Pubmed	Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.	ARHGEF12 GNA13	1.01e-05	2	111	2	19074425
Pubmed	Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia-associated RhoGEF.	ARHGEF12 GNA13	1.01e-05	2	111	2	28465324
Pubmed	Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2).	ABCC1 ABCA2	1.01e-05	2	111	2	15999530
Pubmed	Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.	GPI PARP14	1.01e-05	2	111	2	17875708
Pubmed	Binding of brain spectrin to the 70-kDa neurofilament subunit protein.	SPTAN1 NEFL	1.01e-05	2	111	2	3121319
Pubmed	Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.	ARHGEF12 GNA13	1.01e-05	2	111	2	21507947
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	POLR2B HEATR1 TRIP12 LARP7 SUMO1 UTP20 NUP93 UTP3	1.19e-05	332	111	8	25693804
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	XRN2 USP9X POLR2B TRIP12 YLPM1 ASCC2 NUP93 UTP3 TRMT61A	1.24e-05	440	111	9	34244565
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GPI DNAJC13 NEDD4L USP9X SPTAN1 RAPGEF4 ARHGEF12 ACTN2 SPTBN4 NEFL MGAT3 ZC2HC1A GUCY1A2 EIF3L RIMBP2 PLCH1	1.27e-05	1431	111	16	37142655
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGB2 PCDHGB1 PCDHGB4	1.40e-05	15	111	3	23515096
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	XRN2 POLR2B HEATR1 MORC2 PRPF8 TRIP12 DARS2 EIF3L UTP20 FKBP4 SEC23B	1.64e-05	704	111	11	29955894
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	DNAJC13 NEDD4L SPTAN1 POLR2B APOB PRPF8 TRIP12 DARS2 FADS3 SUMO1 GNA13 EIF3L G6PD FKBP4 SEC23B	1.65e-05	1297	111	15	33545068
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	XRN2 RBM12B TRIP12 LARP7 ZNF711 EIF3L UTP20 FKBP4	1.71e-05	349	111	8	25665578
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	XRN2 DNAJC13 SPTAN1 PRPF8 TRIP12 SUMO1 TUBGCP3 YLPM1 NUP93 SEC23B	1.81e-05	582	111	10	20467437
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC13 SPTAN1 POLR2B HEATR1 PRPF8 HSPA12B DARS2 LARP7 PTCD1 DHCR7 TUBGCP3 ASCC2 PRKAR1B PLCH1 FKBP4 NIN	2.03e-05	1487	111	16	33957083
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	GPI XRN2 POLR2B MORC2 PRPF8 LARP7 SUMO1 EIF3L YLPM1 CFDP1 NUP93 G6PD FKBP4	2.19e-05	1014	111	13	32416067
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	ABCC1 USP9X SPTAN1 HEATR1 PRPF8 DHCR7 EIF3L FKBP4 SEC23B	2.62e-05	484	111	9	31995728
Pubmed	Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.	MGAT3 FMN1	3.02e-05	3	111	2	33200553
Pubmed	Interaction domains of neurofilament light chain and brain spectrin.	SPTAN1 NEFL	3.02e-05	3	111	2	1902666
Pubmed	Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.	ARHGEF12 GNA13	3.02e-05	3	111	2	11094164
Pubmed	Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.	ARHGEF12 GNA13	3.02e-05	3	111	2	19409815
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ABCC1 RBM12B SPTAN1 POLR2B APOB HEATR1 MORC2 PRPF8 DHCR7 NUP93 G6PD	3.07e-05	754	111	11	35906200
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ABCC1 DNAJC13 USP9X SPTAN1 POLR2B NEFL WDR20 YLPM1 NUP93 UTP3 G6PD FKBP4 NIN	3.11e-05	1049	111	13	27880917
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	GPI NEDD4L SPTAN1 APOB MORC2 PRPF8 TRIP12 LARP7 MTFMT DHCR7 TUBGCP3 YLPM1 ASCC2 NUP93 TRMT61A	3.12e-05	1371	111	15	36244648
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	ABCA2 RBM12B ACTN2 YLPM1 RIMBP2	3.97e-05	118	111	5	21078624
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	XRN2 SPTAN1 HEATR1 PRPF8 LARP7 SUMO1 EIF3L YLPM1 NUP93 G6PD	4.10e-05	641	111	10	36057605
Pubmed	The functional interactome landscape of the human histone deacetylase family.	RBM12B USP9X POLR2B HEATR1 YLPM1 NUP93 TRMT61A	4.13e-05	289	111	7	23752268
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	XRN2 RBM12B SPTAN1 POLR2B HEATR1 PRPF8 TRIP12 EIF3L ASCC2 UTP20 NUP93 UTP3 TACSTD2 FKBP4	4.84e-05	1257	111	14	36526897
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DNAJC13 PARP14 PRPF8 TRIP12 DHCR7 UTP20	4.86e-05	202	111	6	33005030
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ABCC1 USP9X POLR2B HEATR1 TRIP12 USP19 DARS2 LPCAT2 DHCR7 EIF3L UTP20 NUP93	4.92e-05	942	111	12	31073040
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	XRN2 PARP14 PRPF8 SUMO1 YLPM1 CCDC87 UTP20 UTP3	5.34e-05	410	111	8	26949251
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	XRN2 RBM12B POLR2B HEATR1 PRPF8 LARP7 PTCD1 EIF3L YLPM1 UTP20 UTP3	5.65e-05	807	111	11	22681889
Pubmed	Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.	RAPGEF4 PLCH1	6.03e-05	4	111	2	21041529
Pubmed	Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes.	CYP27B1 DHCR7	6.03e-05	4	111	2	21441443
Pubmed	Vitamin D pathway gene polymorphisms, vitamin D level, and cytokines in children with type 1 diabetes.	CYP27B1 DHCR7	6.03e-05	4	111	2	33961971
Pubmed	LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics.	ARHGEF12 GNA13	6.03e-05	4	111	2	17959834
Pubmed	mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2.	ABCC1 ABCA2	6.03e-05	4	111	2	24145140
Pubmed	Genetic and age related models of neurodegeneration in mice: dystrophic axons.	GPI SPTBN4	6.03e-05	4	111	2	1634998
Pubmed	Genetic factors controlling structure and expression of apolipoproteins B and E in mice.	GPI APOB	6.03e-05	4	111	2	3034900
Pubmed	The b1 isoform of protocadherin-gamma (Pcdhgamma) interacts with the microtubule-destabilizing protein SCG10.	PCDHGB2 PCDHGB1	6.03e-05	4	111	2	15581637
Pubmed	RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage.	PRPF8 ASCC2	6.03e-05	4	111	2	29997253
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	XRN2 ABCA2 USP9X CYTH1 SPTAN1 RAPGEF4 CUL9 PRPF8 TRIP12 SH2B1 SPTBN4 NEFL YLPM1 USP32	6.13e-05	1285	111	14	35914814
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ABCA2 CUL9 TRIP12 SH2B1 SPTBN4	6.30e-05	130	111	5	12421765
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NEDD4L TRIP12 SH2B1 SUMO1 YLPM1 TONSL CCDC87 WNK4	7.44e-05	430	111	8	35044719
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	XRN2 RBM12B HEATR1 PRPF8 TRIP12 DARS2 SUMO1 YLPM1 UTP20 UTP3 USP27X FKBP4	7.81e-05	989	111	12	36424410
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CYTH1 POLR2B ARHGEF12 HEATR1 MORC2 CASZ1 LARP7 PTCD1 SUMO1 WDR20 EIF3L ASCC2 UTP20 UTP3 TACSTD2	8.43e-05	1497	111	15	31527615
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CUL9 HEATR1 MORC2 PRPF8 TRIP12 CASZ1 SH2B1 DARS2 LARP7 CFDP1 UTP20	9.63e-05	857	111	11	25609649
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGB2 PCDHGB1 PCDHGB4	9.78e-05	28	111	3	15347688
Pubmed	SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization.	SUMO1 NIN	1.00e-04	5	111	2	16154161
Pubmed	Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity.	SPTAN1 SPTBN4	1.00e-04	5	111	2	33790315
Pubmed	Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance.	ARHGEF12 GNA13	1.00e-04	5	111	2	31549965
Pubmed	WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.	NEDD4L WNK4	1.00e-04	5	111	2	23594824
Pubmed	Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.	ARHGEF12 GNA13	1.00e-04	5	111	2	12515866
Pubmed	Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling.	ARHGEF12 GNA13	1.00e-04	5	111	2	23129751
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GPI XRN2 DNAJC13 SPTAN1 POLR2B HEATR1 PRPF8 TRIP12 ZC2HC1A TUBGCP3 EIF3L UTP20 NUP93 G6PD	1.06e-04	1353	111	14	29467282
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	DNAJC13 PARP14 PRPF8 TRIP12 UTP20 NUP93 UTP3	1.14e-04	340	111	7	29478914
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PCDHGB3 LCA5L PARP14 PRPF8 TRIP12 DARS2 CEP95 EIF3L CCDC87 UTP20	1.28e-04	736	111	10	29676528
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	USP9X PRPF8 TRIP12 EIF3L SEC23B	1.36e-04	153	111	5	26365490
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	ENOX1 RBM12B PGBD1 ACTN2 SUMO1P1 ZUP1 NEFL SUMO1 DHCR7 TLR2	1.37e-04	742	111	10	26871637
Pubmed	The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes.	SUMO1P1 SUMO1	1.50e-04	6	111	2	9465300
Pubmed	The chromosome localization and the HCF repeats of the human host cell factor gene (HCFC1) are conserved in the mouse homologue.	RENBP G6PD	1.50e-04	6	111	2	8833156
Pubmed	Potent activation of RhoA by Galpha q and Gq-coupled receptors.	ARHGEF12 GNA13	1.50e-04	6	111	2	12016230
Pubmed	G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension.	ARHGEF12 GNA13	1.50e-04	6	111	2	18084302
Pubmed	A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.	ARHGEF12 GNA13	1.50e-04	6	111	2	20300064
Pubmed	Toll-like receptor polymorphisms in malaria-endemic populations.	TLR2 G6PD	1.50e-04	6	111	2	19317913
Pubmed	In vivo assembly of the axon initial segment in motor neurons.	SPTAN1 SPTBN4	1.50e-04	6	111	2	23728480
Pubmed	Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.	SPTAN1 SPTBN4	1.50e-04	6	111	2	16687515
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	XRN2 DNAJC13 RBM12B POLR2B HEATR1 PRPF8 TRIP12 LARP7 UTP20 UTP3	1.64e-04	759	111	10	35915203
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	PCDHGB2 PCDHGB1 PCDHGB4	1.76e-04	34	111	3	22884324
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	GPI SPTAN1 POLR2B PRPF8 TRIP12 LARP7 ZC2HC1A SUMO1 DHCR7 ASCC2 NUP93 G6PD FKBP4	1.76e-04	1247	111	13	27684187
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	XRN2 POLR2B HEATR1 PRPF8 TRIP12 EIF3L TONSL NUP93 FKBP4	1.81e-04	624	111	9	33729478
Pubmed	Human transcription factor protein interaction networks.	XRN2 USP9X SPTAN1 CUL9 MORC2 SUMO1 WDR20 EIF3L YLPM1 CFDP1 NUP93 USP27X FKBP4 SEC23B	1.87e-04	1429	111	14	35140242
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	XRN2 DNAJC13 SPTAN1 MORC2 TRIP12 ADCY6 USP19 ABCB9 YLPM1 UTP20	1.92e-04	774	111	10	15302935
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	GPI XRN2 SPTAN1 SUMO1 EIF3L NUP93 FKBP4 SEC23B	1.93e-04	494	111	8	26831064
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	HEATR1 PARP14 SUMO1 EIF3L UTP20 SEC23B	2.02e-04	262	111	6	36880596
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	XRN2 NEDD4L USP9X HEATR1 PRPF8 TRIP12 DARS2 FKBP4	2.03e-04	498	111	8	36634849
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	NEDD4L WNK4	2.10e-04	7	111	2	20525693
Pubmed	Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations.	GPI G6PD	2.10e-04	7	111	2	10886019
Interaction	PCDHGB3 interactions	PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	6.00e-08	8	111	4	int:PCDHGB3
Interaction	PCDHGB2 interactions	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.45e-07	44	111	6	int:PCDHGB2
Interaction	SOX2 interactions	GPI DNAJC13 USP9X CYTH1 SPTAN1 CUL9 HEATR1 PRPF8 TRIP12 LARP7 ZC2HC1A PTCD1 SUMO1 EIF3L YLPM1 NUP93 UTP3 PLCH1 TACSTD2 G6PD FKBP4 TRMT61A NIN	2.44e-06	1422	111	23	int:SOX2
Interaction	SIRT7 interactions	XRN2 USP9X SPTAN1 CUL9 HEATR1 PRPF8 TRIP12 LARP7 NEFL EIF3L YLPM1 UTP20 NUP93 FKBP4 SEC23B	1.41e-05	744	111	15	int:SIRT7
Interaction	OBSL1 interactions	GPI XRN2 DNAJC13 RBM12B POLR2B CUL9 HEATR1 PRPF8 TRIP12 LARP7 NEFL SUMO1 YLPM1 UTP20 NUP93 UTP3	3.43e-05	902	111	16	int:OBSL1
Interaction	FBXO22 interactions	USP9X POLR2B RAPGEF4 MORC2 PRPF8 TRIP12 CAPN7 USP32 ASCC2 UTP3 G6PD WNK4	4.30e-05	540	111	12	int:FBXO22
Cytoband	5q31	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	3.96e-07	115	111	6	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	9.10e-05	298	111	6	chr5q31
GeneFamily	Clustered protocadherins	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.56e-07	64	69	6	20
GeneFamily	Ubiquitin specific peptidases	USP9X USP19 USP32 USP27X	6.14e-05	56	69	4	366
GeneFamily	EF-hand domain containing	SPTAN1 SCGN LPCAT2 USP32 PLCH1 NIN	1.87e-04	219	69	6	863
GeneFamily	EF-hand domain containing\|Spectrins	SPTAN1 SPTBN4	2.98e-04	7	69	2	1113
GeneFamily	NLR family	NLRX1 NLRP10	4.07e-03	25	69	2	666
Coexpression	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_UP	NRROS PARP14 CSRNP1 CEP95 WDR20 AEBP2 USP27X G6PD	2.10e-06	200	110	8	M6044
Coexpression	MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED	NLRX1 CUL9 ANO5 PARP14 SPTBN4 DMC1 FADS3 ABCB9 LPCAT2 PRKAR1B TACSTD2	1.86e-05	544	110	11	M1936
Coexpression	GSE3982_DC_VS_NKCELL_UP	CYP27B1 RENBP PTCD1 USP32 UTP3 TACSTD2 SEC23B	2.22e-05	200	110	7	M5478
Coexpression	MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED	NLRX1 CUL9 ANO5 PARP14 SPTBN4 DMC1 FADS3 ABCB9 LPCAT2 PRKAR1B TACSTD2	3.04e-05	574	110	11	MM820
Coexpression	ZHONG_PFC_C3_MICROGLIA	ABCA2 SPTAN1 ACTN2 NEFL FADS3 ZC2HC1A GUCY1A2 PRKAR1B RIMBP2 NUP93	4.06e-05	488	110	10	M39104
Coexpression	RASHI_RESPONSE_TO_IONIZING_RADIATION_3	ABCC1 SH2B1 USP19 YLPM1	4.56e-05	47	110	4	M7248
Coexpression	RASHI_RESPONSE_TO_IONIZING_RADIATION_3	ABCC1 SH2B1 USP19 YLPM1	4.56e-05	47	110	4	MM515
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NLRX1 SCGN SPTBN4 PXT1 RIMBP2 CDH8	4.20e-06	169	111	6	96a2aec9acf8a6f966973c035e5ade456cf47772
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY6 FADS3 GUCY1A2 FAM20A USP27X WNK4	7.27e-06	186	111	6	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn\|World / Primary Cells by Cluster	NEDD4L SPTAN1 POLR2B RENBP ZC2HC1A DISP3	9.80e-06	196	111	6	9401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS PARP14 HSPA12B	1.10e-05	200	111	6	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS PARP14 HSPA12B	1.10e-05	200	111	6	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS PARP14 HSPA12B	1.10e-05	200	111	6	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS PARP14 HSPA12B	1.10e-05	200	111	6	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS PARP14 HSPA12B	1.10e-05	200	111	6	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital\|World / Primary Cells by Cluster	SPTAN1 ACTN2 NEFL ZC2HC1A GUCY1A2 EIF3L	1.10e-05	200	111	6	6bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19\|World / Primary Cells by Cluster	SPTAN1 ACTN2 NEFL ZC2HC1A GUCY1A2 EIF3L	1.10e-05	200	111	6	c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF4 HSPA12B FBXO47 CCDC87 USP27X	4.48e-05	156	111	5	ea9223bb6450b22df11efa1705ab72dab005244a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF4 HSPA12B FBXO47 CCDC87 USP27X	4.48e-05	156	111	5	586b5509074c4cc359e9e31a968c2ded71c994ca
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 SPTBN4 DMC1 FMN1 PCDHGB4	5.52e-05	163	111	5	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 STK32C SH2B1 NEFL ABCB9	6.55e-05	169	111	5	18ba8fc2ba8838484d3b223428cd41568e2ccb10
ToppCell	droplet-Lung-nan-21m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 STK32C SH2B1 NEFL ABCB9	6.55e-05	169	111	5	47a63afd80cb7ba2258ba57d3084d8b2a7bc4e8d
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRIK3 SCGN SPTBN4 RIMBP2 GREB1	6.55e-05	169	111	5	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 STK32C KCNK7 ABCB9 PLCH1	7.12e-05	172	111	5	f45489e80c59b824846ffda675de0d118a8b850c
ToppCell	COPD-Epithelial-PNEC\|Epithelial / Disease state, Lineage and Cell class	RAPGEF4 ANO5 GRIK3 SCGN GREB1	8.59e-05	179	111	5	988d0853c391da1e5004f73f3678047418d3f6d3
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAPGEF4 SCGN SPTBN4 DISP3 RIMBP2	8.59e-05	179	111	5	8ce5000088b727783a0619baa16a2cd036d21f54
ToppCell	facs-GAT-Fat-3m-Lymphocytic-T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA2 ACTN2 CSRNP1 LPCAT2 AEBP2	9.29e-05	182	111	5	751bd3e3b49de961523e98197688a05c998c121a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO5 APOB GRIK3 DISP3 PLCH1	9.78e-05	184	111	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENOX1 CASZ1 FMN1 RIMBP2 WNK4	9.78e-05	184	111	5	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ENOX1 CASZ1 TLR2 RIMBP2 WNK4	9.78e-05	184	111	5	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO5 APOB GRIK3 DISP3 PLCH1	9.78e-05	184	111	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO5 APOB GRIK3 DISP3 PLCH1	9.78e-05	184	111	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO5 SCGN NEFL RIMBP2 GREB1	1.03e-04	186	111	5	2fab7abed16a894afdd0207e86fc43a25a77fb9e
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO5 SCGN NEFL RIMBP2 GREB1	1.03e-04	186	111	5	ea2c8e0df038a00062d2098b4a9ac85141b9a728
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO5 SCGN NEFL RIMBP2 GREB1	1.03e-04	186	111	5	714765585a644bf9817ab6eb3001b43b3c2d2410
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY6 CASZ1 NUP93 TACSTD2 WNK4	1.08e-04	188	111	5	ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ENOX1 FMN1 TLR2 RIMBP2 WNK4	1.11e-04	189	111	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NEDD4L FMN1 TLR2 AEBP2 PLCH1	1.14e-04	190	111	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	XRN2 CYTH1 SPTAN1 HEATR1 NIN	1.14e-04	190	111	5	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	10x5'\|World / Manually curated celltypes from each tissue	GPI ABCC1 PRPF8 CSRNP1 FKBP4	1.28e-04	195	111	5	de28b998793271c4f69ce9e183c3e62d809e9cc8
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GRIK3 SCGN HSPA12B ZNF711 RIMBP2	1.31e-04	196	111	5	4bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ABCC1 RENBP NRROS MGAT3 LPCAT2	1.31e-04	196	111	5	5bb8653af62334ded8aad48b24b64d7b54bc3cd5
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NEDD4L SCGN ZC2HC1A DISP3 FKBP4	1.35e-04	197	111	5	b4554353c56e220bae31ee3c8aa222674dd0b18c
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NEDD4L FMN1 TLR2 PLCH1 FAM20A	1.38e-04	198	111	5	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ARHGEF12 GRIK3 SCGN SAG RIMBP2	1.38e-04	198	111	5	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPTAN1 FADS3 ZC2HC1A CEP95 TACSTD2	1.41e-04	199	111	5	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	SPTAN1 ARHGEF12 NEFL ZC2HC1A EIF3L	1.41e-04	199	111	5	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	SPTAN1 ARHGEF12 NEFL ZC2HC1A EIF3L	1.41e-04	199	111	5	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 PARP14 HSPA12B	1.44e-04	200	111	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 ARHGEF12 NRROS PARP14 HSPA12B	1.44e-04	200	111	5	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS HSPA12B	1.44e-04	200	111	5	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 PARP14 HSPA12B	1.44e-04	200	111	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS HSPA12B	1.44e-04	200	111	5	b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS HSPA12B	1.44e-04	200	111	5	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS HSPA12B	1.44e-04	200	111	5	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 RAPGEF4 ARHGEF12 NRROS HSPA12B	1.44e-04	200	111	5	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	SPTAN1 ARHGEF12 NRROS PARP14 HSPA12B	1.44e-04	200	111	5	432384faeade8e609154fab3d96c955a8ec868dd
Drug	Oxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; MCF7; HT_HG-U133A	ABCA2 NEDD4L ARHGEF16 SH2B1 USP19 DMC1 ABCB9 PRKAR1B TRMT61A	5.12e-07	196	111	9	3568_DN
Disease	mental development measurement	PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	3.00e-08	25	108	5	EFO_0008230
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGB7 PCDHGB6 PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	2.47e-07	71	108	6	EFO_0007878, EFO_0007979
Disease	Sarcosine measurement	PCDHGB3 PCDHGB2 PCDHGB1 PCDHGB4	1.42e-06	23	108	4	EFO_0021668
Disease	congenital nonspherocytic hemolytic anemia (implicated_via_orthology)	GPI G6PD	1.33e-05	2	108	2	DOID:2861 (implicated_via_orthology)
Disease	congenital nonspherocytic hemolytic anemia (is_implicated_in)	GPI G6PD	1.32e-04	5	108	2	DOID:2861 (is_implicated_in)
Disease	Mental Retardation, X-Linked 1	USP9X ZNF711 USP27X	2.19e-04	32	108	3	C2931498
Disease	Anemia, Hemolytic, Acquired	GPI G6PD	1.01e-03	13	108	2	C0002879
Disease	Anemia, Hemolytic	GPI G6PD	1.01e-03	13	108	2	C0002878
Disease	Anemia, Microangiopathic	GPI G6PD	1.01e-03	13	108	2	C0002889
Disease	Microangiopathic hemolytic anemia	GPI G6PD	1.01e-03	13	108	2	C0221021
Disease	type 1 diabetes mellitus (is_marker_for)	APOB TLR2 G6PD	2.37e-03	72	108	3	DOID:9744 (is_marker_for)
Disease	sphingomyelin 22:0 measurement	HEATR1 ACTN2	2.42e-03	20	108	2	EFO_0010395
Disease	total iron binding capacity	DNAJC13 GRIK3 SCGN	2.97e-03	78	108	3	EFO_0006334

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLRFLFEGQRIADNH	SUMO1P1	61	G2XKQ0
DFFDAQTLDAIRHRA	AEBP2	396	Q6ZN18
NAFEIRNHEASQRFD	DISP3	106	Q9P2K9
NEFRASFNHFDRRKN	ACTN2	756	P35609
FSRHRQELFLIEDQA	ANO5	191	Q75V66
HDRVDNLVLDDFKRF	CASZ1	1481	Q86V15
VAAHFLARERRNDEL	ADCY6	956	O43306
RHNVFQNDEFDVFSR	ASCC2	536	Q9H1I8
LGASQRFFEDLEQRH	ARHGEF16	336	Q5VV41
RFFEDLEQRHKAQVL	ARHGEF16	341	Q5VV41
NLVFEEFARHNLKDA	SAG	376	P10523
VRVSDRNFLDSFHIE	CCDC87	446	Q9NVE4
RDIADRFNVDHDAVL	DMC1	171	Q14565
FRVANHQKDLFRRTD	DHCR7	351	Q9UBM7
RDLFVAERQFAKEQH	ARHGEF12	1206	Q9NZN5
VAAFRNFSDEIRHNL	NUP93	731	Q8N1F7
VGAFENFRHQLEDLR	RBM12B	521	Q8IXT5
NFRHQLEDLRQLDNF	RBM12B	526	Q8IXT5
ESEILRRHSFFDDNI	RAD21L1	161	Q9H4I0
EIENLQAQFELRAFH	FMN1	736	Q68DA7
ALNERKAEVRLQFHD	G6PD	361	P11413
AQRAFDHEQLRAFAL	PCDHGB6	516	Q9Y5F9
RAFDHEQLRAFELTL	PCDHGB4	516	Q9UN71
AQRAFDHEQLRTFEL	PCDHGB7	516	Q9Y5F8
FAFAQRHVERREAEA	CYP27B1	261	O15528
TFERFRHAQLLDAAK	RENBP	81	P51606
NRFLCDDVDFNLRVH	GREB1	1736	Q4ZG55
AINVNHEFDLLDVRF	MGAT3	211	Q09327
LAAEGIQHQRFLFEE	NLRP10	416	Q86W26
AEFAQEQARARHEKL	CSRNP1	126	Q96S65
DFFIRQIHKFEELNR	EIF3L	541	Q9Y262
AELRAELAAFQAEHR	KCNK7	41	Q9Y2U2
FAQRAFDHEQLRAFE	PCDHGB1	511	Q9Y5G3
FDHEQLRAFELTLQA	PCDHGB1	516	Q9Y5G3
AQRAFDHEQLRAFEL	PCDHGB2	516	Q9Y5G2
DNFAHRAEVRKALAN	NIPSNAP3B	91	Q9BS92
LGERDEFNIQVLHAF	CYTH1	116	Q15438
FGDANLHKDRFLREQ	LARP7	46	Q4G0J3
IDEHFFGVALENNRR	LCA5L	11	O95447
ESLRFLSFRLDFNEH	TUBGCP3	871	Q96CW5
LRRLFDANKDRFNHF	GPI	26	P06744
IHGQDFDQRAREEFR	GNA13	71	Q14344
EEFQLLHIFRRDALR	NLRX1	461	Q86UT6
AQRAFDHEQLRAFEL	PCDHGB3	516	Q9Y5G1
ALRFFREHALQELRE	HSPA12B	176	Q96MM6
EQHISFALDVDNRFL	NBPF1	1181	Q3BBV0
LNFVFGVNIEHRDLD	MORC2	366	Q9Y6X9
LRQLFALFDRNHDGS	LPCAT2	396	Q7L5N7
ALFDRNHDGSIDFRE	LPCAT2	401	Q7L5N7
HENIQAFSDEFARRA	PARP14	1176	Q460N5
AAFSHAQVFELERRF	NKX3-2	211	P78367
RHFEKNRNNALDFVT	APOB	3206	P04114
AFLDRVDHRQFEIER	CFDP1	276	Q9UEE9
CLQDRFRFNEIHSLN	CRYGD	111	P07320
RHITDKDDFANNREF	CAPN7	591	Q9Y6W3
DQFAREALRALHAAR	MTFMT	56	Q96DP5
GAFERLFQHLERSLD	ABCA2	1286	Q9BZC7
AQAFTEAFERELRRH	CEP95	481	Q96GE4
FSRLHLFASEQREEI	DNAJC13	176	O75165
DRDEDDRSFLNLFHL	FBXO47	416	Q5MNV8
VLFAHLDDNERSDIF	PRKAR1B	136	P31321
VLRHEQNFADRFLPD	CUL9	1346	Q8IWT3
FLEALDFRAQHSEND	HEATR1	1871	Q9H583
RFSIDRHTDLERQFN	CDH8	426	P55286
DADLNDERVQRALHF	CST2	36	P09228
LFRRGEAHLAVNDFE	FKBP4	356	Q02790
EAHLAVNDFELARAD	FKBP4	361	Q02790
EEHAFRFSANIINRN	GRIK3	56	Q13003
TDAFRAFHQDLNFVR	FADS3	71	Q9Y5Q0
SAAELRNFLRDLFLH	SCGN	126	O76038
DQVDDFHEARSRAAL	UTP3	46	Q9NQZ2
SGRLHVDFAQARDDF	ENOX1	211	Q8TC92
FDGLAELRHLNLAFN	NRROS	201	Q86YC3
RAFEEQERFIHQSDL	ABCC1	1166	P33527
EFFNICFHENERVLR	GUCY1A2	176	P33402
FDQRHLDDINFDVRF	UTP20	1436	O75691
REQHDALEFFNSLVD	USP9X	1681	Q93008
FNLLSRDLEKFRQHA	RIMBP2	51	O15034
EAAFSRRFAELFLQH	SH2B1	61	Q9NRF2
RRFAELFLQHFEAEV	SH2B1	66	Q9NRF2
DNCHFLRVDKEDFNR	RAPGEF4	441	Q8WZA2
RKDIESIRNFAADHF	DARS2	381	Q6PI48
QDQHEARLKELFDSF	NIN	6	Q8N4C6
AFNHSDLDAELRRLF	TACSTD2	166	P09758
NAEIAAFHLDRILDF	FAM20A	261	Q96MK3
AHGAAQFLRERLFEA	POLR2B	1096	P30876
DEDFQDLLHFGRDRA	WDR20	331	Q8TBZ3
SLRFLFEGQRIADNH	SUMO1	61	P63165
DRFELIFSNLHFADN	PGBD1	496	Q96JS3
EFNGDHFLLERAIRA	OXCT2	191	Q9BYC2
QLRHIEAAFDQEAAA	SEC23B	511	Q15437
EDVNFDHFQILRAIG	STK32C	86	Q86UX6
DRSLLEDIRHFNIFD	ABCB9	31	Q9NP78
HIFFRFTADEARDLI	PRPF8	1096	Q6P2Q9
VRFHLQDFDRLSANR	TMEM17	171	Q86X19
LRDFFHDRSFEAEIN	USP19	521	O94966
RQQDAHEFLIAALDV	USP27X	161	A6NNY8
LAEQNHLYEDLFRAR	TONSL	191	Q96HA7
RAQLADSFHLQQFFR	SPTAN1	566	Q13813
FHQQRAEKAREEFQE	TRMT61A	136	Q96FX7
FNRDRRPVHLDQAAF	XRN2	801	Q9H0D6
AAGRLQRFLHDLDAF	SPTBN4	1086	Q9H254
RKNREAFQTFLDELH	PRPF40B	491	Q6NWY9
RQSEIFHRQAEGNFD	PLCH1	76	Q4KWH8
FDRQSNVIADHRDFK	YLPM1	1696	P49750
QRRFNENAADRHINF	ZC2HC1A	126	Q96GY0
AHFEQNTLERNFERI	ZUP1	51	Q96AP4
AAQFHNLRFGERRDE	PTCD1	106	O75127
FGDERELQRHLDLFQ	ZNF711	571	Q9Y462
FARLVDNFQHEENLL	TRIP12	626	Q14669
HFRLFDENNDAAILI	TLR2	721	O60603
DLQQDGRDALDHFVF	PXT1	101	Q8NFP0
FTIQDLLAHAFFREE	WNK4	421	Q96J92
LFNAFDENRDNHIDF	USP32	236	Q8NFA0
NHNILQARDRIEDFF	ZPBP2	231	Q6X784
DLNDRFASFIERVHE	NEFL	96	P07196
NHRLLFEVFDENRLT	NEDD4L	86	Q96PU5