Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nicotinic acid receptor activity	HCAR2 HCAR3	6.14e-05	2	157	2	GO:0070553
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.59e-04	35	157	4	GO:0015020
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.99e-07	8	153	4	GO:0070980
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B4 UGT2B10 UGT2B28 UGT2B11	5.90e-07	10	153	4	GO:0018879
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.38e-06	12	153	4	GO:0052697
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.58e-05	21	153	4	GO:0052695
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT2B4 UGT2B10 UGT2B28 UGT2B11	3.83e-05	26	153	4	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT2B4 UGT2B10 UGT2B28 UGT2B11	3.83e-05	26	153	4	GO:0006063
GeneOntologyBiologicalProcess	benzene-containing compound metabolic process	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.59e-04	37	153	4	GO:0042537
GeneOntologyBiologicalProcess	xenobiotic catabolic process	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.59e-04	37	153	4	GO:0042178
GeneOntologyBiologicalProcess	tRNA metabolic process	MARS2 CARS1 FTSJ1 GTF3C5 TYW1B PTCD1 PRORP ADAT1	1.71e-04	209	153	8	GO:0006399
GeneOntologyBiologicalProcess	androgen metabolic process	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.77e-04	38	153	4	GO:0008209
GeneOntologyCellularComponent	nuclear outer membrane	SYNE2 UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.12e-05	40	155	5	GO:0005640
Domain	UDPGT	UGT2B4 UGT2B10 UGT2B28 UGT2B11	2.32e-05	21	153	4	PF00201
Domain	UDPGT	UGT2B4 UGT2B10 UGT2B28 UGT2B11	2.32e-05	21	153	4	PS00375
Domain	UDP_glucos_trans	UGT2B4 UGT2B10 UGT2B28 UGT2B11	2.32e-05	21	153	4	IPR002213
Domain	WD40_repeat_dom	DCAF6 FBXW10 AHI1 GRWD1 UBR4 WDR70 APAF1 SEC31B TECPR2 HERC1 SON	3.45e-05	297	153	11	IPR017986
Domain	CNKSR2	CNKSR2 CNKSR3	6.67e-05	2	153	2	IPR010599
Domain	HCAR2/3_rcpt	HCAR2 HCAR3	6.67e-05	2	153	2	IPR028017
Domain	DUF1170	CNKSR2 CNKSR3	6.67e-05	2	153	2	PF06663
Domain	E1_4HB	UBA1 UBA6	1.99e-04	3	153	2	PF16191
Domain	E1_FCCH	UBA1 UBA6	1.99e-04	3	153	2	PF16190
Domain	UBQ-activ_enz_E1	UBA1 UBA6	1.99e-04	3	153	2	IPR018075
Domain	UBA_e1_C	UBA1 UBA6	1.99e-04	3	153	2	SM00985
Domain	CRIC	CNKSR2 CNKSR3	1.99e-04	3	153	2	PS51290
Domain	Ub-activating_enz_E1_C	UBA1 UBA6	1.99e-04	3	153	2	IPR018965
Domain	CRIC_domain	CNKSR2 CNKSR3	1.99e-04	3	153	2	IPR017874
Domain	CRIC_ras_sig	CNKSR2 CNKSR3	1.99e-04	3	153	2	PF10534
Domain	VPS13	VPS13D VPS13A	1.99e-04	3	153	2	IPR026847
Domain	VPS13_mid_rpt	VPS13D VPS13A	1.99e-04	3	153	2	PF16910
Domain	VPS13	VPS13D VPS13A	1.99e-04	3	153	2	PF16908
Domain	E1_4HB	UBA1 UBA6	1.99e-04	3	153	2	IPR032420
Domain	E1_FCCH	UBA1 UBA6	1.99e-04	3	153	2	IPR032418
Domain	E1_UFD	UBA1 UBA6	1.99e-04	3	153	2	PF09358
Domain	VPS13_N2	VPS13D VPS13A	1.99e-04	3	153	2	IPR031646
Domain	VPS13_mid_rpt	VPS13D VPS13A	1.99e-04	3	153	2	IPR031642
Domain	TPR-contain_dom	P4HA2 TTC28 TTC14 PRPF6 TTC3 TTC29 VPS13A	2.39e-04	150	153	7	IPR013026
Domain	HEAT_REPEAT	MROH2A HEATR6 MROH2B MMS19 TANGO6	2.72e-04	70	153	5	PS50077
Domain	WD40	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B TECPR2 HERC1	3.72e-04	268	153	9	SM00320
Domain	SHR-BD	VPS13D VPS13A	3.96e-04	4	153	2	IPR009543
Domain	-	UBA1 UBA6	3.96e-04	4	153	2	1.10.3240.10
Domain	VPS13_C	VPS13D VPS13A	3.96e-04	4	153	2	PF16909
Domain	VPS13_C	VPS13D VPS13A	3.96e-04	4	153	2	IPR031645
Domain	SHR-BD	VPS13D VPS13A	3.96e-04	4	153	2	PF06650
Domain	WD40_repeat	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B TECPR2 HERC1	4.15e-04	272	153	9	IPR001680
Domain	-	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B TECPR2 HERC1 SON	4.29e-04	333	153	10	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B TECPR2 HERC1 SON	4.49e-04	335	153	10	IPR015943
Domain	WD_REPEATS_1	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B TECPR2 HERC1	4.86e-04	278	153	9	PS00678
Domain	ARM-type_fold	MON2 DOCK3 MROH2A UBR4 URB1 HEATR6 MROH2B MMS19 PUM1 TANGO6	4.93e-04	339	153	10	IPR016024
Domain	WD_REPEATS_2	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B TECPR2 HERC1	4.99e-04	279	153	9	PS50082
Domain	WD_REPEATS_REGION	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B TECPR2 HERC1	4.99e-04	279	153	9	PS50294
Domain	IQ	DCAF6 MYO9B UBE3B SCN2A SCN9A	5.37e-04	81	153	5	SM00015
Domain	UBIQUITIN_ACTIVAT_1	UBA1 UBA6	6.56e-04	5	153	2	PS00536
Domain	UBA_E1_Cys	UBA1 UBA6	6.56e-04	5	153	2	IPR019572
Domain	UBIQUITIN_ACTIVAT_2	UBA1 UBA6	6.56e-04	5	153	2	PS00865
Domain	UBA_e1_thiolCys	UBA1 UBA6	6.56e-04	5	153	2	PF10585
Domain	TPR_2	P4HA2 TTC28 TTC14 TTC3	7.44e-04	50	153	4	PF07719
Domain	TPR_2	P4HA2 TTC28 TTC14 TTC3	7.44e-04	50	153	4	IPR013105
Domain	TPR_repeat	P4HA2 TTC28 TTC14 PRPF6 TTC3 TTC29	7.99e-04	133	153	6	IPR019734
Domain	IQ_motif_EF-hand-BS	DCAF6 MYO9B UBE3B SCN2A SCN9A	8.68e-04	90	153	5	IPR000048
Domain	Na_trans_cytopl	SCN2A SCN9A	9.79e-04	6	153	2	PF11933
Domain	Na_trans_cytopl	SCN2A SCN9A	9.79e-04	6	153	2	IPR024583
Domain	UBQ/SUMO-activ_enz_E1-like	UBA1 UBA6	9.79e-04	6	153	2	IPR000011
Domain	IQ	DCAF6 MYO9B UBE3B SCN2A SCN9A	1.01e-03	93	153	5	PS50096
Domain	WD40	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B HERC1	1.35e-03	259	153	8	PF00400
Domain	CRAL-TRIO_dom	PRUNE2 PLEKHG4 ARHGAP1	1.52e-03	28	153	3	IPR001251
Domain	Flavodoxin/NO_synth	TYW1B NOS3	1.81e-03	8	153	2	IPR008254
Domain	Chorein_N	VPS13D VPS13A	1.81e-03	8	153	2	PF12624
Domain	DHC_N1	DNAH5 DNAH9	1.81e-03	8	153	2	PF08385
Domain	Flavdoxin-like	TYW1B NOS3	1.81e-03	8	153	2	IPR001094
Domain	VPS13_N	VPS13D VPS13A	1.81e-03	8	153	2	IPR026854
Domain	FLAVODOXIN_LIKE	TYW1B NOS3	1.81e-03	8	153	2	PS50902
Domain	Flavodoxin_1	TYW1B NOS3	1.81e-03	8	153	2	PF00258
Domain	Dynein_heavy_dom-1	DNAH5 DNAH9	1.81e-03	8	153	2	IPR013594
Domain	WD40_repeat_CS	FBXW10 GRWD1 WDR70 APAF1 SEC31B HERC1	2.34e-03	164	153	6	IPR019775
Domain	SAM_1	CNKSR2 BFAR CASKIN2 CNKSR3	2.35e-03	68	153	4	PF00536
Domain	TPR_REGION	P4HA2 TTC28 TTC14 TTC3 TTC29 VPS13A	2.41e-03	165	153	6	PS50293
Domain	TPR	P4HA2 TTC28 TTC14 TTC3 TTC29 VPS13A	2.41e-03	165	153	6	PS50005
Domain	Na_channel_asu	SCN2A SCN9A	2.87e-03	10	153	2	IPR001696
Domain	ThiF_NAD_FAD-bd	UBA1 UBA6	2.87e-03	10	153	2	IPR000594
Domain	Na_trans_assoc	SCN2A SCN9A	2.87e-03	10	153	2	IPR010526
Domain	ThiF	UBA1 UBA6	2.87e-03	10	153	2	PF00899
Domain	Na_trans_assoc	SCN2A SCN9A	2.87e-03	10	153	2	PF06512
Domain	-	TYW1B NOS3	2.87e-03	10	153	2	3.40.50.360
Domain	Flavoprotein-like_dom	TYW1B NOS3	2.87e-03	10	153	2	IPR029039
Domain	CRAL_TRIO_2	PRUNE2 ARHGAP1	4.17e-03	12	153	2	PF13716
Domain	TPR	TTC28 TTC14 PRPF6 TTC3 TTC29	4.21e-03	129	153	5	SM00028
Domain	Rossmann-like_a/b/a_fold	MARS2 CARS1 CRY1	5.23e-03	43	153	3	IPR014729
Domain	-	MARS2 CARS1 CRY1	5.23e-03	43	153	3	3.40.50.620
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH9	5.69e-03	14	153	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH9	5.69e-03	14	153	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH9	5.69e-03	14	153	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH9	5.69e-03	14	153	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH9	5.69e-03	14	153	2	IPR011704
Domain	MT	DNAH5 DNAH9	5.69e-03	14	153	2	PF12777
Domain	AAA_8	DNAH5 DNAH9	5.69e-03	14	153	2	PF12780
Domain	AAA_5	DNAH5 DNAH9	5.69e-03	14	153	2	PF07728
Domain	SAM	CNKSR2 BFAR CASKIN2 CNKSR3	5.93e-03	88	153	4	SM00454
Domain	TPR_1	TTC28 TTC14 PRPF6 TTC3	6.41e-03	90	153	4	IPR001440
Domain	TPR_1	TTC28 TTC14 PRPF6 TTC3	6.41e-03	90	153	4	PF00515
Domain	DHC_fam	DNAH5 DNAH9	6.53e-03	15	153	2	IPR026983
Domain	Dynein_heavy	DNAH5 DNAH9	6.53e-03	15	153	2	PF03028
Domain	Dynein_heavy_dom	DNAH5 DNAH9	6.53e-03	15	153	2	IPR004273
Domain	tRNAsynth_Ia_anticodon-bd	MARS2 CARS1	6.53e-03	15	153	2	IPR009080
Domain	ARM-like	MON2 MROH2A HEATR6 MROH2B MMS19 PUM1 TANGO6	6.92e-03	270	153	7	IPR011989
Domain	-	P4HA2 TTC28 TTC14 PRPF6 TTC3 TTC29	7.24e-03	207	153	6	1.25.40.10
Domain	SAM_DOMAIN	CNKSR2 BFAR CASKIN2 CNKSR3	7.75e-03	95	153	4	PS50105
Pathway	REACTOME_PREDNISONE_ADME	UGT2B4 UGT2B10 ALB UGT2B28 UGT2B11	9.08e-07	23	113	5	MM16639
Pathway	REACTOME_ASPIRIN_ADME	UGT2B4 UGT2B10 ALB UGT2B28 UGT2B11	2.56e-05	44	113	5	M45014
Pathway	REACTOME_ASPIRIN_ADME	UGT2B4 UGT2B10 ALB UGT2B28 UGT2B11	2.86e-05	45	113	5	MM15694
Pathway	REACTOME_GLUCURONIDATION	UGT2B4 UGT2B10 UGT2B28 UGT2B11	3.67e-05	24	113	4	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2B4 UGT2B10 UGT2B28 UGT2B11	4.35e-05	25	113	4	M17787
Pathway	WP_GLUCURONIDATION	UGT2B4 UGT2B10 UGT2B28 UGT2B11	4.35e-05	25	113	4	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT2B4 UGT2B10 UGT2B28 UGT2B11	4.35e-05	25	113	4	M605
Pathway	WP_GLUCURONIDATION	UGT2B4 UGT2B10 UGT2B28 UGT2B11	5.11e-05	26	113	4	M39404
Pathway	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	UGT2B4 UGT2B10 UGT2B28 UGT2B11	6.91e-05	28	113	4	M19580
Pathway	KEGG_RETINOL_METABOLISM	UGT2B4 UGT2B10 UGT2B28 UGT2B11 RPE65	1.58e-04	64	113	5	M9488
Pathway	REACTOME_PARACETAMOL_ADME	UGT2B4 UGT2B10 UGT2B28 UGT2B11	2.59e-04	39	113	4	MM15695
Pathway	KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	UGT2B4 UGT2B10 UGT2B28 UGT2B11	3.15e-04	41	113	4	M7399
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.42e-08	7	158	4	26074487
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B4 UGT2B10 UGT2B28 UGT2B11	2.83e-08	8	158	4	32093886
Pubmed	cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.	UGT2B4 UGT2B10 UGT2B11	9.20e-08	3	158	3	8333863
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 DOCK3 EPPK1 RHBDF2 CTC1 MYO9B UBE3B UBR4 WDR70 DYSF TTC3 ADCY9 FAM20C URB1 PCNX4 TTLL4 SNX8 HERC1 PUM1 ADAT1	1.61e-07	1105	158	20	35748872
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MARS2 SET TBRG4 GRWD1 CHAF1A RGS22 UBR4 RBM26 CARS1 PRPF6 TTC3 GTF3C5 DDX10 URB1 UBA1 CLCA2 UBA6 DKC1 UHRF1 PUM1 DNAH5 RAD21	5.56e-07	1425	158	22	30948266
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	SET CHAF1A UBR4 WDR70 RBM26 PRPF6 XRCC1 PHF8 GTF3C5 UBA1 PAPOLA HLTF UBA6 DKC1 UHRF1 MMS19 SON RAD21	9.28e-07	1014	158	18	32416067
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	CLSTN3 PHACTR2 TBRG4 AHI1 PLEKHG4 APAF1 RAD9B FTSJ1 XRCC1 TTC3 ADCY3 PAPOLA CASKIN2 DKC1 UHRF1 RUBCN ADAT1	1.19e-06	925	158	17	28986522
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZNF821 P4HA2 SET AHI1 GRWD1 CTC1 TTC14 ANKRD49 CDCP1 TTC3 ADCY3 URB1 PAPOLA TYW1B PTCD1 TTLL4 HERC1 PUM1	2.37e-06	1084	158	18	11544199
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	MON2 UBR4 ADCY3 ARHGAP1 UBA1 FSTL1 PCNX4 SYNE2 MMS19 TANGO6	2.40e-06	322	158	10	26514267
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MON2 ACSL6 CLSTN3 TTC28 CNKSR2 PHF8 ADCY3 USP8 PUM1 RUBCN SON	2.85e-06	407	158	11	12693553
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PRUNE2 TTC28 APAF1 PHF8 ADCY9 URB1 SYNE2 UNC80	9.49e-06	225	158	8	12168954
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EPPK1 MYO9B PRPF6 XRCC1 GTF3C5 MYEF2 DDX10 URB1 UBA1 SYNE2 UBA6 DKC1 UHRF1 ALB PUM1 SON	1.88e-05	1024	158	16	24711643
Pubmed	The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.	LCK DUSP22	2.05e-05	2	158	2	24714587
Pubmed	Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.	HCAR2 HCAR3	2.05e-05	2	158	2	28186140
Pubmed	The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.	HCAR2 HCAR3	2.05e-05	2	158	2	30154797
Pubmed	The role of HCA2 (GPR109A) in regulating macrophage function.	HCAR2 HCAR3	2.05e-05	2	158	2	23882124
Pubmed	Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.	HCAR2 HCAR3	2.05e-05	2	158	2	36891315
Pubmed	Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.	HCAR2 HCAR3	2.05e-05	2	158	2	38007572
Pubmed	Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.	HCAR2 HCAR3	2.05e-05	2	158	2	24691444
Pubmed	Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.	HCAR2 HCAR3	2.05e-05	2	158	2	31347703
Pubmed	Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.	HCAR2 HCAR3	2.05e-05	2	158	2	30659164
Pubmed	Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.	HCAR2 HCAR3	2.05e-05	2	158	2	19223991
Pubmed	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.	HCAR2 HCAR3	2.05e-05	2	158	2	23967184
Pubmed	Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.	HCAR2 HCAR3	2.05e-05	2	158	2	26371038
Pubmed	Identification and characteristics of a novel E1 like gene nUBE1L in human testis.	UBA1 UBA6	2.05e-05	2	158	2	15202508
Pubmed	Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.	HCAR2 HCAR3	2.05e-05	2	158	2	34653248
Pubmed	Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).	HCAR2 HCAR3	2.05e-05	2	158	2	19136666
Pubmed	G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.	HCAR2 HCAR3	2.05e-05	2	158	2	33488584
Pubmed	Lactate-induced activation of HCA2 improves survival in mice with sepsis.	HCAR2 HCAR3	2.05e-05	2	158	2	30951370
Pubmed	Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.	HCAR2 HCAR3	2.05e-05	2	158	2	31858105
Pubmed	Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.	HCAR2 HCAR3	2.05e-05	2	158	2	32068460
Pubmed	The Escherichia coli adherence factor plasmid of enteropathogenic Escherichia coli causes a global decrease in ubiquitylated host cell proteins by decreasing ubiquitin E1 enzyme expression through host aspartyl proteases.	UBA1 UBA6	2.05e-05	2	158	2	22999844
Pubmed	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	HCAR2 HCAR3	2.05e-05	2	158	2	30657794
Pubmed	Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.	HCAR2 HCAR3	2.05e-05	2	158	2	34092246
Pubmed	Molecular identification of high and low affinity receptors for nicotinic acid.	HCAR2 HCAR3	2.05e-05	2	158	2	12522134
Pubmed	G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.	HCAR2 HCAR3	2.05e-05	2	158	2	30271409
Pubmed	A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming.	XRCC1 RAD21	2.05e-05	2	158	2	27916276
Pubmed	Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.	HCAR2 HCAR3	2.05e-05	2	158	2	30596513
Pubmed	The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.	HCAR2 HCAR3	2.05e-05	2	158	2	35320002
Pubmed	GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.	HCAR2 HCAR3	2.05e-05	2	158	2	16322797
Pubmed	Nicotinic acid receptor agonists.	HCAR2 HCAR3	2.05e-05	2	158	2	18983141
Pubmed	Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.	HCAR2 HCAR3	2.05e-05	2	158	2	31366236
Pubmed	Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK.	TNFSF11 NOS3	2.05e-05	2	158	2	12824189
Pubmed	Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Nav1.5.	UBA1 UBA6	2.05e-05	2	158	2	32315024
Pubmed	GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.	HCAR2 HCAR3	2.05e-05	2	158	2	35489706
Pubmed	Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.	HCAR2 HCAR3	2.05e-05	2	158	2	19561068
Pubmed	The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.	HCAR2 HCAR3	2.05e-05	2	158	2	24371223
Pubmed	High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.	HCAR2 HCAR3	2.05e-05	2	158	2	21774590
Pubmed	GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.	HCAR2 HCAR3	2.05e-05	2	158	2	36208084
Pubmed	The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.	HCAR2 HCAR3	2.05e-05	2	158	2	26656756
Pubmed	Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.	HCAR2 HCAR3	2.05e-05	2	158	2	37597514
Pubmed	The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.	HCAR2 HCAR3	2.05e-05	2	158	2	33924461
Pubmed	Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.	HCAR2 HCAR3	2.05e-05	2	158	2	33977048
Pubmed	PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.	HCAR2 HCAR3	2.05e-05	2	158	2	11745392
Pubmed	Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.	HCAR2 HCAR3	2.05e-05	2	158	2	25622782
Pubmed	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.	HCAR2 HCAR3	2.05e-05	2	158	2	33420329
Pubmed	Molecular identification of nicotinic acid receptor.	HCAR2 HCAR3	2.05e-05	2	158	2	12646212
Pubmed	PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.	HCAR2 HCAR3	2.05e-05	2	158	2	12563315
Pubmed	Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice.	TNFSF11 NOS3	2.05e-05	2	158	2	17038532
Pubmed	UHRF1 inhibition epigenetically reprograms cancer stem cells to suppress the tumorigenic phenotype of hepatocellular carcinoma.	UHRF1 ALB	2.05e-05	2	158	2	37380646
Pubmed	Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.	HCAR2 HCAR3	2.05e-05	2	158	2	30625381
Pubmed	Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.	HCAR2 HCAR3	2.05e-05	2	158	2	30085883
Pubmed	Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.	HCAR2 HCAR3	2.05e-05	2	158	2	21655214
Pubmed	(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.	HCAR2 HCAR3	2.05e-05	2	158	2	15929991
Pubmed	Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.	HCAR2 HCAR3	2.05e-05	2	158	2	36991440
Pubmed	Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.	UGT2B28 UGT2B11	2.05e-05	2	158	2	21679149
Pubmed	Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.	HCAR2 HCAR3	2.05e-05	2	158	2	25320346
Pubmed	Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells.	HCAR2 HCAR3	2.05e-05	2	158	2	21441844
Pubmed	BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.	HCAR2 HCAR3	2.05e-05	2	158	2	31914599
Pubmed	Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.	HCAR2 HCAR3	2.05e-05	2	158	2	20655299
Pubmed	Evidence for constitutive dimerization of niacin receptor subtypes.	HCAR2 HCAR3	2.05e-05	2	158	2	20380810
Pubmed	GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.	HCAR2 HCAR3	2.05e-05	2	158	2	26116596
Pubmed	Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.	HCAR2 HCAR3	2.05e-05	2	158	2	35649469
Pubmed	GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.	HCAR2 HCAR3	2.05e-05	2	158	2	37595951
Pubmed	The hypophagic response to heat stress is not mediated by GPR109A or peripheral β-OH butyrate.	HCAR2 HCAR3	2.05e-05	2	158	2	26936786
Pubmed	Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.	HCAR2 HCAR3	2.05e-05	2	158	2	34084164
Pubmed	The calcium channel TRPV6 is a novel regulator of RANKL-induced osteoclastic differentiation and bone absorption activity through the IGF-PI3K-AKT pathway.	TNFSF11 TRPV6	2.05e-05	2	158	2	33159483
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	GRWD1 UBR4 RBM26 PRPF6 XRCC1 PHF8 MYEF2 DDX10 PAPOLA	2.81e-05	341	158	9	32971831
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ZNF618 UBR4 PHF8 CSMD2 DIPK2B FAM20C URB1 TNFSF11 TRPM3 TLR3 VPS13A ALB RPE65	3.43e-05	736	158	13	29676528
Pubmed	The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells.	TNFSF11 NOS3	6.13e-05	3	158	2	18440890
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN9A	6.13e-05	3	158	2	19284629
Pubmed	Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.	HCAR2 HCAR3	6.13e-05	3	158	2	23579073
Pubmed	Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose.	HCAR2 HCAR3	6.13e-05	3	158	2	37215085
Pubmed	Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.	HCAR2 HCAR3	6.13e-05	3	158	2	20033346
Pubmed	Specificity of the E1-E2-E3 enzymatic cascade for ubiquitin C-terminal sequences identified by phage display.	UBA1 UBA6	6.13e-05	3	158	2	23003343
Pubmed	International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).	HCAR2 HCAR3	6.13e-05	3	158	2	21454438
Pubmed	Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL-18 and glutamatergic synaptic activity.	HCAR2 HCAR3	6.13e-05	3	158	2	34919284
Pubmed	Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism.	FSTL1 NOS3	6.13e-05	3	158	2	18718903
Pubmed	The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.	HCAR2 HCAR3	6.13e-05	3	158	2	24845831
Pubmed	Oral Dimethyl Fumarate Targets HCA2-Expressing Skin Cells in the Imiquimod Mouse Model.	HCAR2 HCAR3	6.13e-05	3	158	2	35189149
Pubmed	The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.	HCAR2 HCAR3	6.13e-05	3	158	2	33597149
Pubmed	Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.	HCAR2 HCAR3	6.13e-05	3	158	2	17008386
Pubmed	Effects of high fat diet on GPR109A and GPR81 gene expression.	HCAR2 HCAR3	6.13e-05	3	158	2	22842580
Pubmed	Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.	HCAR2 HCAR3	6.13e-05	3	158	2	22914621
Pubmed	SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation.	SNX8 SNX1	6.13e-05	3	158	2	21973056
Pubmed	Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.	HCAR2 HCAR3	6.13e-05	3	158	2	32093510
Pubmed	Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.	CLCA2 LY75	6.13e-05	3	158	2	25557950
Pubmed	Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases.	HCAR2 HCAR3	6.13e-05	3	158	2	34852802
Pubmed	Niacin stimulates adiponectin secretion through the GPR109A receptor.	HCAR2 HCAR3	6.13e-05	3	158	2	19141678
Pubmed	Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.	HCAR2 HCAR3	6.13e-05	3	158	2	20664170
Interaction	ACSM5 interactions	MARS2 TBRG4 UBR4 PTCD1 ALDH4A1 PRORP	3.84e-06	55	154	6	int:ACSM5
Interaction	UGT2B28 interactions	UGT2B10 UGT2B28 UGT2B11	8.61e-06	6	154	3	int:UGT2B28
Interaction	MTNR1B interactions	MON2 UBR4 ADCY3 ARHGAP1 FSTL1 PCNX4 SYNE2 TANGO6	9.45e-06	135	154	8	int:MTNR1B
Interaction	APEX1 interactions	CLSTN3 SET PHACTR2 TBRG4 AHI1 PLEKHG4 CHAF1A WDR70 APAF1 RAD9B FTSJ1 XRCC1 PHF8 TTC3 ADCY3 DDX10 URB1 BBX PAPOLA CASKIN2 DKC1 UHRF1 RUBCN ADAT1 RAD21	1.20e-05	1271	154	25	int:APEX1
Interaction	CIB2 interactions	CTC1 APAF1 ADCY3 GTF3C5 TANGO6 RAD21	3.65e-05	81	154	6	int:CIB2
Cytoband	4q13.2	UBA6 UGT2B10 UGT2B28 UGT2B11	3.95e-06	31	158	4	4q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q13	UGT2B4 UBA6 UGT2B10 ALB UGT2B28 UGT2B11	1.86e-05	157	158	6	chr4q13
Cytoband	2q24	SCN9A LY75	6.34e-04	11	158	2	2q24
GeneFamily	UDP glucuronosyltransferases	UGT2B4 UGT2B10 UGT2B28 UGT2B11	4.09e-05	32	110	4	363
GeneFamily	Hydroxy-carboxylic acid receptors	HCAR2 HCAR3	1.10e-04	3	110	2	200
GeneFamily	WD repeat domain containing	DCAF6 FBXW10 AHI1 GRWD1 WDR70 APAF1 SEC31B HERC1	2.00e-04	262	110	8	362
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	PRUNE2 ARHGAP1	7.55e-04	7	110	2	1299
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN9A	1.28e-03	9	110	2	1203
GeneFamily	Ubiquitin like modifier activating enzymes	UBA1 UBA6	1.60e-03	10	110	2	100
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY3 ADCY9	1.60e-03	10	110	2	53
GeneFamily	Maestro heat like repeat containing	MROH2A MROH2B	1.95e-03	11	110	2	636
GeneFamily	Sterile alpha motif domain containing	CNKSR2 BFAR CASKIN2 CNKSR3	2.04e-03	88	110	4	760
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX8 SNX1	2.33e-03	12	110	2	1290
GeneFamily	Dyneins, axonemal	DNAH5 DNAH9	4.70e-03	17	110	2	536
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC28 TTC14 TTC3 TTC29	5.35e-03	115	110	4	769
GeneFamily	Aminoacyl tRNA synthetases, Class I	MARS2 CARS1	5.86e-03	19	110	2	131
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SPTA1 RGS22 CNKSR2 TRPM3 SCN2A SCN9A DNAH5 DNAH9 UNC80	1.21e-09	184	158	10	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SPTA1 RGS22 CNKSR2 TRPM3 SCN2A SCN9A DNAH5 DNAH9 UNC80	1.21e-09	184	158	10	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SPTA1 RGS22 CNKSR2 TRPM3 SCN2A SCN9A DNAH5 DNAH9 UNC80	1.21e-09	184	158	10	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10\|TCGA-Brain / Sample_Type by Project: Shred V9	RGS22 LGI4 TTC29 TLR3 DNAH5 DNAH9 CFAP99	2.67e-06	171	158	7	74be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	PHACTR2 GXYLT1 DIPK2B FSTL1 SCN9A SHE GPRC5B	3.11e-06	175	158	7	16849ea8f0985108baa2085f34c3de14a4f9f28b
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCAR2 NPY6R ATP10B DYSF TECPR2 SCN2A LY75	3.88e-06	181	158	7	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTC28 DUSP8 FSTL1 CASKIN2 SIGIRR NOS3 GPRC5B	3.88e-06	181	158	7	136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TTC28 RBM26 DNAAF9 TTC3 UNC80 SON	4.98e-06	188	158	7	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DYSF DIPK2B PTPN3 CNKSR3 SHE NOS3 GPRC5B	5.16e-06	189	158	7	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	DYSF DIPK2B CASKIN2 CNKSR3 SHE NOS3 GPRC5B	6.99e-06	198	158	7	f83956c4b13b5d0a0c6e3d9f580dbf99649ef175
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)\|390C / Donor, Lineage, Cell class and subclass (all cells)	DYSF DIPK2B CASKIN2 CNKSR3 SHE NOS3 GPRC5B	6.99e-06	198	158	7	5b5ccce5de82ea041465e656147cec3b8beb865b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK3 WFDC1 ATP10B CSMD2 SCN2A SCN9A UNC80	7.23e-06	199	158	7	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	COVID-19_Severe-dn_T\|COVID-19_Severe / Disease condition and Cell class	PHACTR2 CARS1 PTPN3 MROH2B IRAG2 ECI2	1.18e-05	142	158	6	2008033881b9e1b20926c3508d6ebdb6f1a1528f
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DUSP8 DIPK2B KRTDAP SCN2A SHE NOS3	1.67e-05	151	158	6	3b4c57bad61e17a573e6f8dc6b917fba5fd56c43
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A ATP10B LGALS12 APOC4 ST8SIA3 ALB	2.31e-05	160	158	6	f2cdee5a9e3b0eb125d6be7b5d239eb04333ae41
ToppCell	Leuk-UTI-Myeloid-tDC\|Leuk-UTI / Disease, Lineage and Cell Type	CHAF1A PROZ BBX TLR3 SCN9A HLTF	2.40e-05	161	158	6	51b9f60986ed2e8e2297d31c80462c3ab65a2e5e
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|368C / Donor, Lineage, Cell class and subclass (all cells)	DYSF DIPK2B CNKSR3 SCN9A SHE GPRC5B	3.04e-05	168	158	6	a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	DYSF DIPK2B CNKSR3 SCN9A SHE GPRC5B	3.04e-05	168	158	6	dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	LCK URB1 SYNE2 GRAP2 VPS13A IRAG2	3.15e-05	169	158	6	bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SPTA1 SCN9A DNAH5 DNAH9 UNC80	3.15e-05	169	158	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AHI1 LCK ERI2 GRAP2 UBA6 LY75	3.25e-05	170	158	6	3ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell	356C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	P4HA2 DNAAF9 SEC31B ARHGAP1 URB1 HEATR6	3.47e-05	172	158	6	4977e1f4deae781750e27a8054deccd336cfb74a
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AHI1 CSMD2 LGI4 ST8SIA3 SCN9A UNC80	3.83e-05	175	158	6	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AHI1 CSMD2 LGI4 ST8SIA3 SCN9A UNC80	3.83e-05	175	158	6	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PHACTR2 TTC28 WFDC1 MYEF2 TNFSF11 RPE65	4.08e-05	177	158	6	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAD9B LGALS12 CNKSR2 CDCP1 TTLL4 SCN2A	4.08e-05	177	158	6	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	4.76e-05	111	158	5	9ba3590be8862c23b6e2917caed8bdbd9f9c2753
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	4.76e-05	111	158	5	3e38efb22c47506ef2e2c1e19c79450e11d0ce56
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	4.76e-05	111	158	5	cd84f2a9102a6eb63226ecde11d4ece54ff99b48
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DYSF DIPK2B PTPN3 CNKSR3 SHE NOS3	4.91e-05	183	158	6	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 TRPM3 SLC17A1 SYNE2 CNKSR3 VPS13A	5.06e-05	184	158	6	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 CNKSR2 LGI4 TRPM3 SCN9A UNC80	5.37e-05	186	158	6	d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 P4HA2 ADCY9 FAM20C TRPM3 SLC17A1	5.37e-05	186	158	6	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 P4HA2 NAT8B FAM20C TRPM3 SLC17A1	5.53e-05	187	158	6	1b82920588f9e26ef1db244d452736d75fcfd342
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 P4HA2 ADCY9 FAM20C TRPM3 SLC17A1	5.53e-05	187	158	6	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 ADCY9 TRPM3 SLC17A1 CNKSR3 VPS13A	5.53e-05	187	158	6	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 PTPN3 TRPM3 SLC17A1 SCN2A SYNE2	5.53e-05	187	158	6	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 P4HA2 NAT8B FAM20C TRPM3 SLC17A1	5.53e-05	187	158	6	c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TTC28 DYSF DIPK2B CASKIN2 CNKSR3 SHE	5.70e-05	188	158	6	117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCell	Endothelial-endothelial_cell_of_lymph_vessel\|World / Lineage, Cell type, age group and donor	DYSF DIPK2B PTPN3 CNKSR3 SHE GPRC5B	5.70e-05	188	158	6	80910dcbb51990f2baed240f319456c0d3fa2065
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRUNE2 WFDC1 MYEF2 TSGA10IP RPE65	5.70e-05	188	158	6	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYSF DIPK2B CASKIN2 SHE NOS3 GPRC5B	5.87e-05	189	158	6	db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF618 PTPN3 CLCA2 SCN2A TRPV6 GPRC5B	6.04e-05	190	158	6	e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF618 PTPN3 CLCA2 SCN2A TRPV6 GPRC5B	6.04e-05	190	158	6	f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF618 PTPN3 CLCA2 SCN2A TRPV6 GPRC5B	6.04e-05	190	158	6	b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRUNE2 DUSP8 WFDC1 MYEF2 TSGA10IP	6.04e-05	190	158	6	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	facs-Aorta-Heart-24m-Myeloid-professional_antigen_presenting_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCAR2 LGALS12 BFAR KRTDAP TANGO6	6.37e-05	118	158	5	171afacd54b2e447f9f8c4511e93ff4504cd47cc
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DYSF DIPK2B CNKSR3 SHE NOS3 GPRC5B	6.40e-05	192	158	6	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 DNAAF9 TRPM3 SLC17A1 SYNE2 EXOC6B	6.40e-05	192	158	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CTC1 TTC14 SEC31B SYNE2 VPS13A HERC1	6.59e-05	193	158	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DOCK3 CLSTN3 TTC3 SCN2A HERC1 UNC80	6.59e-05	193	158	6	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	6.63e-05	119	158	5	a3807e738d7ca8cf80aa4bd35e3ee4357b1dc00f
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	6.63e-05	119	158	5	8a3f0a3ed9f80d7b061162e9fa519bb09804a86c
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	6.63e-05	119	158	5	938da0fe90372709048bf4e5503cc1cbf8376b17
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRUNE2 AHI1 FAM20C UBA1 SCN9A SON	6.78e-05	194	158	6	8985095f291c1b54e45f4edece49aa26e8c8b732
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DYSF DIPK2B CASKIN2 CNKSR3 SHE GPRC5B	6.78e-05	194	158	6	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DYSF DIPK2B CASKIN2 CNKSR3 SHE GPRC5B	6.78e-05	194	158	6	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBXW10 RGS22 TTC29 DNAH5 DNAH9 CFAP99	6.78e-05	194	158	6	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 TTC3 VPS13A HERC1 UNC80 SON	6.98e-05	195	158	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PHACTR2 CNKSR2 CSMD2 FSTL1 TRPM3 SCN2A	6.98e-05	195	158	6	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 TTC3 VPS13A HERC1 UNC80 SON	6.98e-05	195	158	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	distal-Endothelial-Lymphatic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DYSF DIPK2B PTPN3 CNKSR3 SCN9A GPRC5B	6.98e-05	195	158	6	f45c1349932ee7eb419cced8a4fdedae3610953f
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYSF DIPK2B CASKIN2 SHE NOS3 GPRC5B	7.18e-05	196	158	6	c5fe470f11ee4962bcfb30cddfd8c078af5b1222
ToppCell	frontal_cortex-Neuronal\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CLSTN3 AHI1 TTC3 ST8SIA3 SCN2A UNC80	7.18e-05	196	158	6	de7d10da862f98894ce47244fbc992f4a12d63bb
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHI1 CSMD2 SYNE2 IRAG2 DNAH5 SON	7.38e-05	197	158	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	390C-Endothelial_cells\|390C / Donor, Lineage, Cell class and subclass (all cells)	DYSF DIPK2B CASKIN2 CNKSR3 SHE GPRC5B	7.38e-05	197	158	6	aa381acea0f7882d39435a6f713386bf0588b5f8
ToppCell	(5)_Dendritic_cell-(54)_pDC\|(5)_Dendritic_cell / shred on Cell_type and subtype	AHI1 TTC28 SEC31B CNKSR3 SCN9A RUBCN	7.59e-05	198	158	6	fc6c6b60dddd7f2f997af0f87fae33f1c23f34a8
ToppCell	ASK452-Endothelial-Endothelium\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	PHACTR2 DIPK2B CASKIN2 SYNE2 CNKSR3 NOS3	7.59e-05	198	158	6	e282769f5fa1765bcce79a0ed9d761bf2e14b012
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 NAT8B SLC17A1 DNAJC12 ALDH4A1 ALB	7.59e-05	198	158	6	72733b6149b797ac11cc108bc80428b77fbbba78
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYSF DIPK2B CASKIN2 SHE NOS3 GPRC5B	7.59e-05	198	158	6	e9e98c20ff7b3f3851db86381550ce7085e2db9e
ToppCell	medial-Endothelial-Lymphatic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DYSF DIPK2B PTPN3 CNKSR3 SCN9A GPRC5B	7.59e-05	198	158	6	41983d405215b974044e2e9e6c212b134336a6fe
ToppCell	medial-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DYSF DIPK2B PTPN3 CNKSR3 SCN9A GPRC5B	7.59e-05	198	158	6	e4274584512a72270087a1ab104fab449a2f83bc
ToppCell	PSB\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PRUNE2 P4HA2 RGS22 CLCA2 TTC29 DNAJC12	7.59e-05	198	158	6	4e6b0d1abc55d7a0d89bd7ecf0f13dc5bed66626
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 NAT8B SLC17A1 DNAJC12 ALDH4A1 ALB	7.59e-05	198	158	6	f23559ce6072e3c323f6791ff95269271b0f7ff1
ToppCell	medial-Endothelial-Lymphatic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DYSF DIPK2B PTPN3 CNKSR3 SCN9A GPRC5B	7.59e-05	198	158	6	1760fede363544bc0fa2e22fe36aff522abd2525
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	DUSP8 DYSF DIPK2B SHE NOS3	7.76e-05	123	158	5	e0130010aa406d4e9d8f16ad32858c382277eeb2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK3 WFDC1 ATP10B CSMD2 UNC80 GPRC5B	7.80e-05	199	158	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DYSF DIPK2B PTPN3 CNKSR3 SCN9A GPRC5B	7.80e-05	199	158	6	1587d24b19f5bb64a3b6cc1df87c7c472cf41672
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DYSF DIPK2B PTPN3 CNKSR3 SCN9A GPRC5B	7.80e-05	199	158	6	a9c2041e54899cb8ccc026758647f3ae3ca457dd
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK3 WFDC1 ATP10B CSMD2 UNC80 GPRC5B	7.80e-05	199	158	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	21\|World / Age, Tissue, Lineage and Cell class	HCAR2 SPTA1 LCK HCAR3 GRAP2 ALB	7.80e-05	199	158	6	8c6517243168de4134e06dbe16ca89b1c2a73179
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	ACSL6 CSMD2 LGI4 ST8SIA3 SCN2A SCN9A	8.02e-05	200	158	6	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 NAT8B SLC17A1 DNAJC12 ALDH4A1 ALB	8.02e-05	200	158	6	e118d5e6e5d5bb808877a6667668c36f21afad5b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 NAT8B UBR4 SLC17A1 SYNE2 ALDH4A1	8.02e-05	200	158	6	105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 NAT8B SLC17A1 DNAJC12 ALDH4A1 ALB	8.02e-05	200	158	6	234e5a927eec0e235226586451ba3754c8a14169
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	ACSL6 CSMD2 LGI4 ST8SIA3 SCN2A SCN9A	8.02e-05	200	158	6	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	1.04e-04	131	158	5	d46bb28612b9690b2e3550b8adbd10781788c00d
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NAT8B DIPK2B SIGIRR SHE LY75	1.04e-04	131	158	5	308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Shox2_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CDCP1 PROZ C11orf91 TRPV6	1.06e-04	69	158	4	72031d97bf3a3f3e8fe2ad1130c766e39b3b4c46
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Shox2_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CDCP1 PROZ C11orf91 TRPV6	1.06e-04	69	158	4	20bda1222efe784b025c6b311a7813b3b562ec71
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	1.12e-04	133	158	5	bc29a2faa151b0e48c1c7e3f016cccc49f9a15eb
ToppCell	PBMC-Mild-cDC_2\|Mild / Compartment, Disease Groups and Clusters	EPPK1 LCK FSTL1 SYNE2 DNAH9	1.20e-04	135	158	5	cb9d834f8301cf53f20e09c3f4cb6a148690196a
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	1.29e-04	137	158	5	306b11b3b9e5fd562d845fb5eaa4ac982864efce
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK\|Striatum / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	1.29e-04	137	158	5	d37f425b13bc046baa1f8619b98a16b936f88ff6
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	1.38e-04	139	158	5	34398a6f21a1e670497655a7bb7f3cde9e117560
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	1.38e-04	139	158	5	450c4152c9fe4ec503271bb3cf93739918c59509
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RHBDF2 DIPK2B SIGIRR SHE LY75	1.58e-04	143	158	5	35d3652680c4dddd293301595d813161c66e5673
ToppCell	droplet-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8B CLSTN3 APOC4 ALDH4A1 ALB	1.68e-04	145	158	5	f142b86d4da5b71c189da46cbc4beebdc387ffee
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Signet-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	LDHAL6B UGT2B28 PRORP UGT2B11	2.07e-04	82	158	4	73ddc0286bea35f6d283cea30000a541cc6543c7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PHACTR2 LCK PTPN3 SYNE2 ECI2	2.09e-04	152	158	5	405d19b290232bb3e564d61c0cff0cfdd247bdff
Drug	AC1Q6OQG	TNFSF11 UGT2B4 UGT2B10 UGT2B28 UGT2B11	3.06e-06	33	158	5	CID000009686
Drug	AC1NOWCJ	UGT2B4 UGT2B10 ALB UGT2B28 UGT2B11	4.14e-06	35	158	5	CID005120112
Drug	C1 11-32	UGT2B4 UGT2B10 UGT2B28 UGT2B11	6.33e-06	18	158	4	CID000443077
Drug	C11131	UGT2B4 UGT2B10 UGT2B28 UGT2B11	6.33e-06	18	158	4	CID000443076
Drug	propofol	HCAR2 LDHAL6B APOC4 TYRO3 HCAR3 SIGIRR SCN9A UGT2B4 NOS3	7.80e-06	191	158	9	CID000004943
Drug	T4-G	UGT2B4 UGT2B10 UGT2B28 UGT2B11	7.98e-06	19	158	4	CID000152424
Drug	2-AF	DOCK3 UGT2B4 UGT2B10 UGT2B28 UGT2B11	9.25e-06	41	158	5	CID000005800
Drug	estriol-16-glucuronide	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.22e-05	21	158	4	CID000122281
Drug	estradiol-3-glucuronide	UGT2B4 UGT2B10 UGT2B28 UGT2B11	1.78e-05	23	158	4	CID000066651
Drug	Nicotinic Acids	HCAR2 HCAR3 NOS3	1.79e-05	8	158	3	ctd:D009539
Drug	AC1NQGK1	UGT2B4 UGT2B10 ALB UGT2B28 UGT2B11	3.02e-05	52	158	5	CID005195977
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B4 UGT2B10 UGT2B11	1.19e-05	9	156	3	EFO_0600040
Disease	X-19141 measurement	SLC17A1 UGT2B4 UGT2B11	3.99e-05	13	156	3	EFO_0800799
Disease	Diabetic Angiopathies	ADCY3 ALB NOS3	7.72e-05	16	156	3	C0011875
Disease	Microangiopathy, Diabetic	ADCY3 ALB NOS3	7.72e-05	16	156	3	C0025945
Disease	X-21410 measurement	FAM200A PTCD1 SLC17A1	7.72e-05	16	156	3	EFO_0800813
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13D VPS13A	8.30e-05	3	156	2	DOID:0111611 (implicated_via_orthology)
Disease	sphingomyelin 14:0 measurement	PAPOLA TRPM3 SYNE2	9.33e-05	17	156	3	EFO_0010390
Disease	phosphatidylcholine 36:4 measurement	UGT2B4 UGT2B28 UGT2B11	1.12e-04	18	156	3	EFO_0010382
Disease	X-24947 measurement	SLC17A1 UGT2B4 UGT2B11	2.07e-04	22	156	3	EFO_0800910
Disease	proprotein convertase subtilisin/kexin type 9 measurement	PHACTR2 CNKSR2 DDX10	2.07e-04	22	156	3	EFO_0009312
Disease	obsolete_red blood cell distribution width	MARS2 P4HA2 HCAR2 AHI1 TTC28 MYO9B SPTA1 CHAF1A UBE3B APOC4 ADCY9 HCAR3 KRTDAP SYNE2 VPS13A UGT2B10 DKC1 HERC1	2.86e-04	1347	156	18	EFO_0005192
Disease	vanillylmandelate (VMA) measurement	UGT2B4 UGT2B10	5.73e-04	7	156	2	EFO_0800119
Disease	uveal melanoma disease severity	WDR70 CNKSR3	5.73e-04	7	156	2	EFO_0010244
Disease	Hepatic Insufficiency	ALB NOS3	9.76e-04	9	156	2	C1306571
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN2A SCN9A	9.76e-04	9	156	2	C3502809
Disease	sclerostin measurement	INO80C TNFSF11	9.76e-04	9	156	2	EFO_0010606
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN9A	1.22e-03	10	156	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN9A	1.22e-03	10	156	2	DOID:0080422 (implicated_via_orthology)
Disease	complement C1q tumor necrosis factor-related protein 5 measurement	P4HA2 APAF1	1.48e-03	11	156	2	EFO_0801494
Disease	Occupational Diseases	XRCC1 ALB	1.48e-03	11	156	2	C0028797
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN9A	1.77e-03	12	156	2	DOID:0060170 (implicated_via_orthology)
Disease	amygdala volume	MOV10L1 CNKSR3	2.08e-03	13	156	2	EFO_0006934
Disease	Infantile Severe Myoclonic Epilepsy	SCN2A SCN9A	2.08e-03	13	156	2	C0751122
Disease	Situs ambiguus	DNAH5 DNAH9	2.79e-03	15	156	2	C0266642
Disease	plasminogen activator inhibitor 1 measurement	UBR4 MOV10L1 SNX8	2.95e-03	54	156	3	EFO_0004792
Disease	response to TNF antagonist	RBM26 ATP10B CSMD2	2.95e-03	54	156	3	EFO_0004653
Disease	Dyskeratosis Congenita	CTC1 DKC1	3.17e-03	16	156	2	C0265965
Disease	pre-eclampsia (biomarker_via_orthology)	TLR3 NOS3	3.59e-03	17	156	2	DOID:10591 (biomarker_via_orthology)
Disease	bacteriemia	DOCK3 UGT2B4	3.59e-03	17	156	2	EFO_0003033
Disease	omega-3 polyunsaturated fatty acid measurement	AHI1 WDR70 APOC4 TYW1B	3.62e-03	118	156	4	EFO_0010119
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN2A HERC1	4.02e-03	18	156	2	HP_0002373
Disease	disease progression measurement	UGT2B4 HERC1 UGT2B11	4.17e-03	61	156	3	EFO_0008336
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	HCAR2 APOC4 HCAR3 TYW1B SYNE2	4.30e-03	200	156	5	EFO_0004611, EFO_0020945
Disease	skin sensitivity to sun	RXFP3 DUSP22	4.48e-03	19	156	2	EFO_0004795
Disease	Malignant neoplasm of breast	UBR4 LDHAL6B WFDC1 APOC4 DYSF TTC3 ZNF25 DDX10 TAS2R13 CLCA2 SYNE2 DNAH9 NOS3	4.73e-03	1074	156	13	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
RISLDILKDKWSPAL	UBE2NL	86	Q5JXB2
DKTAKIWSFDLLLPL	APAF1	1106	O14727
LKPVFLNSWIDLRAT	ERI2	171	A8K979
KAWAVARLSQRFPKA	ALB	236	P02768
LLESARPVKFLWKLE	CLSTN3	426	Q9BQT9
LQWHPLLAKKLLDFS	BBX	26	Q8WY36
ALIPGDVFAKNSLWK	CSMD2	3266	Q7Z408
RKAWASFDPKALLPL	CTC1	561	Q2NKJ3
FRKIAWAFLKLLGAN	AHI1	471	Q8N157
FSWKLLVPKDRLSLV	CDCP1	446	Q9H5V8
LLPWLDKSIEFIDKA	DUSP8	221	Q13202
AAWIRKIKGLPIDNF	FBXW10	1021	Q5XX13
WSKDAPSELLRKFRN	DNAJC12	181	Q9UKB3
WDLKPIADRAQIFLK	ALDH4A1	116	P30038
KIWSPLEESRIFNRK	DCAF6	786	Q58WW2
RDLGPLTKAWFLESK	APOC4	91	P55056
KKTALIRARDPWAQD	CHAF1A	576	Q13111
PAFRASWIAQKLNLA	CTBS	116	Q01459
FQKWLQAKRLTPDLV	DIPK2B	151	Q9H7Y0
SAFWIKIKDDFPLLS	FAM200A	496	Q8TCP9
PDKNLLTKVRDAALW	ATP10B	546	O94823
SFQKLLSRIARDKWP	ADAT1	441	Q9BUB4
ARFKGQDLKLAWNKP	RBM26	946	Q5T8P6
FVLSKRGPLAKIWLA	RAD21	6	O60216
SPRWLEASKAIRKQL	PTPN3	81	P26045
FWPKAKCALLRDDLV	MFN1	161	Q8IWA4
DEFWLDPSKKGLALR	RAD9B	26	Q6WBX8
AALRWEEKKALAAAP	CFAP99	551	D6REC4
LSLNFPRKLWKIVES	HSFY1	76	Q96LI6
ESLIAAREPFSWKKL	MOV10L1	451	Q9BXT6
ALKIWDLRQFKSGSP	GRWD1	331	Q9BQ67
LKSWKSSRIFLFNLA	HCAR2	56	Q8TDS4
QKELKDFLPSLWASI	MMS19	291	Q96T76
NASDLRLPSRAWKVK	HERC1	4501	Q15751
WLTEKPELFQLALKA	PCNX4	1011	Q63HM2
WHALFESIKRKLPFL	KRTDAP	66	P60985
ESIKRKLPFLNWDAF	KRTDAP	71	P60985
NWDAFPKLKGLRSAT	KRTDAP	81	P60985
ISRWGQKKLISAPFL	LGALS12	266	Q96DT0
AWKLSAFPKNRIIGS	LDHAL6B	196	Q9BYZ2
LFLRPVDDIWSLLKK	GXYLT1	221	Q4G148
PYDRLKLSLLTKVWN	HEATR6	551	Q6AI08
WRAGRPTIKNEKFLA	LY75	1336	O60449
SLEPEPWFFKNLSRK	LCK	121	P06239
STLNAGKWFVKPELR	GDPD4	276	Q6W3E5
EKDPSRLLLWAAEKN	ANKRD49	71	Q8WVL7
TLLKKWAGIFRNILD	EXOC6B	436	Q9Y2D4
WARLTPADKAAIRKE	PHACTR2	596	O75167
LSLLVKFLDADKPQW	MON2	336	Q7Z3U7
KFLDADKPQWLRAVA	MON2	341	Q7Z3U7
SGILKVRALKDFWNL	CASKIN2	281	Q8WXE0
AKAAARDIFSPKRSW	NOS3	716	P29474
VLKRKAVLWQDSFSP	PUM1	6	Q14671
AYKLVKRLNTDWPAL	P4HA2	86	O15460
FKRWKLNGAFLLITA	GPRC5B	226	Q9NZH0
ILLSKAEWSKLFEAP	PAPOLA	351	P51003
CVENWPSKKDRLLFT	NPY6R	196	Q99463
KNLKQILASERALPW	INO80C	106	Q6PI98
KWEGFPKVSILLRDA	BFAR	76	Q9NZS9
NVDLLALLKWKAFPD	DOCK3	606	Q8IZD9
FLPDLSLAKRKTWRN	FAM20C	391	Q8IXL6
WKLSFQEFLKCLNPS	FSTL1	211	Q12841
ADVFPRLFKEWNITK	CRY1	81	Q16526
KLLSAKLPELDWFLQ	DNAAF9	696	Q5TEA3
AFPKKLVAFSTWIDR	ADCY3	686	O60266
QKKLPQLFERASSRW	ADCY9	76	O60503
KNILAAPGILKFWAF	DUSP22	166	Q9NRW4
RKANKALWLSIAFIV	IRAG2	491	Q12912
WTRLKAFAKLPPNAL	ECI2	331	O75521
KDLARLSLKNPEYVW	DDX10	261	Q13206
PFKASLLNIIKRWSL	DNAH9	1091	Q9NYC9
LWSLLSFLKLKPFID	HLTF	596	Q14527
FLWTEKFPSLNKLVD	GRAP2	116	O75791
KLDTSQWPLLLKNFD	DKC1	46	O60832
FSKDLLIKIWNDPLF	RUBCN	776	Q92622
AFWRLDKTESKIPAR	DYSF	1891	O75923
LPRALKDWQAFLDLK	DNAH5	1456	Q8TE73
AKSFALLKWLSLPLF	TBRG4	336	Q969Z0
LLKWLSLPLFEAFAQ	TBRG4	341	Q969Z0
AWEDKLIQFLRNSLK	MROH2A	641	A6NES4
FRKALKSLLWRIASP	RXFP3	396	Q9NSD7
AKLRQAFLLVAAKVW	TAS2R13	286	Q9NYV9
PQKLPWKTLRAAFQA	TSGA10IP	336	Q3SY00
PVKINLFKFLSSWSL	RPE65	256	Q16518
LSEKRSPNDFALWKA	CARS1	311	P49589
AAPDLWIDAKKPFSL	PRUNE2	2066	Q8WUY3
KVWNDLRPKLSCLFA	SNX8	431	Q9Y5X2
LGRALALWDKLFNLK	SYNE2	1641	Q8WXH0
FVRNLPFDLTWQKLK	MYEF2	526	Q9P2K5
PKTFKCRAIELSWFQ	LGI4	201	Q8N135
WLALDQKLEASLKLP	PLEKHG4	636	Q58EX7
SAELKFWHLRQAKPR	RGS22	521	Q8NE09
ALQVFPSKKSVWLRA	PRPF6	566	O94906
LKSWKSSRIFLFNLA	HCAR3	56	P49019
LKQDPESAWFKTFIL	SLC17A1	421	Q14916
ASRKELIPAAFATWL	EPPK1	1916	P58107
LWAKDAAITLKAINP	ARHGAP1	401	Q07960
NLKEKIFISFAWLPK	SLC9B2	446	Q86UD5
SFRLLRVFKLAKSWP	SCN9A	836	Q15858
SSDFWKEVQLALPRK	SIGIRR	296	Q6IA17
FQKRSELIAKIPNFW	SET	81	Q01105
FFLSLKKLDGAILWI	ST8SIA3	231	O43173
ELKSFKSLLWAFPLE	NLRP7	21	Q8WX94
KSLLWAFPLEDVLQK	NLRP7	26	Q8WX94
LPASKANDVLVRWKR	PROZ	26	P22891
IQLWDLRFASSPLKV	SEC31B	241	Q9NQW1
KKSLISFLLHLWDPN	MROH2B	1431	Q7Z745
ACLPDAKTQRLFFKW	PRORP	506	O15091
LKVALELPASKFLWL	URB1	606	O60287
KIFSQANTPLKRWLL	ACSL6	376	Q9UKU0
ANTPLKRWLLEFAAK	ACSL6	381	Q9UKU0
FFRNIKILIPATWKA	CLCA2	81	Q9UQC9
SFNFTPAPLKNLRWK	CNK3/IPCEF1	296	G9CGD6
KSLLAWLDRSPFAAV	CNKSR2	136	Q8WXI2
SFNFTPAPLKNLRWK	CNKSR3	296	Q6P9H4
LSDFNIWKKLFVPLK	C11orf91	36	Q3C1V1
AKNIWKRALPARLAE	WFDC1	31	Q9HC57
IRLKDGSLFWQSPKR	UBA6	726	A0AVT1
ASLPKIDDFSFQWLK	TLR3	341	O15455
EEWALLAPSQKKLYR	ZNF791	16	Q3KP31
TKLAKLAFWLLAVPA	ZNF618	901	Q5T7W0
FKTPEDARWILTKLQ	VPS13A	3151	Q96RL7
LWRQTSAFLRPKLGK	UNC80	26	Q8N2C7
REAEARLLWANKPDK	SNX1	431	Q13596
SALAKIPQKVLWRFD	UGT2B4	326	P06133
FLPSVRLLKAQKSWI	TRPM3	51	Q9HCF6
SLKLWDIRQFNKPLF	WDR70	401	Q9NW82
LPLLFSHFLWSKLKE	nan	91	Q6ZSR6
SFRLLRVFKLAKSWP	SCN2A	851	Q99250
FLKDPQWKNLKLLRD	TANGO6	61	Q9C0B7
QKRIWESPLLLAAKD	TRPV6	81	Q9H1D0
PKLAAWIQKLNSFGL	TTC3	901	P53804
KADLLFALSWKSDAP	TTC14	71	Q96N46
ALLWKIEQKSNRAFA	TECPR2	861	O15040
PSLAKAIAAWKLQLE	SPTA1	1911	P02549
LFPRLDQSRTWLVKA	MARS2	576	Q96GW9
TALAKIPQKVLWRFD	UGT2B11	326	O75310
QFLFRPWDVTKLKSD	UBA1	516	P22314
WLDLAKRSKLEAQPF	TNFSF11	151	O14788
WRARSAFKLLQLDKE	FTSJ1	21	Q9UET6
WLRKDLKPSVLFQEL	UBE3B	616	Q7Z3V4
AKLWNEVLASLKDRP	UHRF1	691	Q96T88
ALDDAIKARLLNPKW	TTC28	111	Q96AY4
EWKLLTPAQRTLYKD	ZNF25	21	P17030
EAARVRSLFWLQKPL	TTC29	96	Q8NA56
FGPDKLVRAAAEKRW	XRCC1	111	P18887
ALAKIPQKVLWRFDG	UGT2B10	326	P36537
KLLEAQTPSVRKWAL	ZNF821	246	O75541
LNLAFRAWTRKEALP	PHF8	436	Q9UPP1
KLFDIRPIWSRNAVK	GTF3C5	256	Q9Y5Q8
TALAKIPQKVLWRFD	UGT2B28	326	Q9BY64
SPWKDSALQSALKLR	PTCD1	221	O75127
WFKEFPLNLKTVSER	SHE	41	Q5VZ18
DADIWKKFLSRPALP	UBR4	4706	Q5T4S7
SFILPQDAKLLRKAW	TTLL4	696	Q14679
LLERPWKAFLNLSAI	RHBDF2	741	Q6PJF5
FLKFLLGVWAKELNA	PRPF18	191	Q99633
LFKWESKTVLRNEPL	USP8	281	P40818
AWIKKDQFLRAAPVT	SON	2291	P18583
ASKLPVKWLALESLA	TYRO3	691	Q06418
SLKKIDRPLFKDFWQ	TYW1B	476	Q6NUM6
ALIANFGIPKWAREK	TMEM145	366	Q8NBT3
LKKAASWLFKNAEPL	VPS13D	2666	Q5THJ4
SWLFKNAEPLKSLSL	VPS13D	2671	Q5THJ4
LDARSKWSNVFKVLL	L1TD1	801	Q5T7N2
ELWRGKKLVAAASPS	MYO9B	1311	Q13459
FSLSLLPALWFLAKK	NAT8B	66	Q9UHF3