Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	BMPR1B EPHA6 ACVR1B ACVR1C EPHA7	1.69e-05	85	75	5	GO:0019199
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	BMPR1B ACVR1B ACVR1C	5.54e-05	20	75	3	GO:0004675
GeneOntologyMolecularFunction	transporter activity	ATP8B3 CACNA1E SLC22A9 SLC10A2 IPO8 TRPM7 BEST2 CNGB3 KCNMA1 SLC38A7 SV2C TMED10 SLC22A20P TAP1 SLC38A6	7.53e-05	1289	75	15	GO:0005215
GeneOntologyMolecularFunction	melatonin receptor activity	GPR50 MTNR1B	8.31e-05	4	75	2	GO:0008502
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1E SLC22A9 SLC10A2 IPO8 TRPM7 BEST2 CNGB3 KCNMA1 SLC38A7 SV2C TMED10 SLC22A20P TAP1 SLC38A6	1.11e-04	1180	75	14	GO:0022857
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GPR161 BMPR1B GPR50 EPHA6 HTR6 GPR153 OR6C76 OR52E6 MTNR1B ACVR1B ACVR1C IL2RG S1PR4 ADGRG6 EPHA7	1.29e-04	1353	75	15	GO:0004888
GeneOntologyMolecularFunction	activin receptor activity, type I	ACVR1B ACVR1C	1.38e-04	5	75	2	GO:0016361
GeneOntologyMolecularFunction	L-glutamine transmembrane transporter activity	SLC38A7 SLC38A6	4.93e-04	9	75	2	GO:0015186
GeneOntologyMolecularFunction	activin receptor activity	ACVR1B ACVR1C	4.93e-04	9	75	2	GO:0017002
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC22A9 SLC10A2 BEST2 SLC38A7 SLC22A20P SLC38A6	8.17e-04	293	75	6	GO:0008514
GeneOntologyMolecularFunction	activin binding	ACVR1B ACVR1C	8.97e-04	12	75	2	GO:0048185
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHA6 EPHA7	1.42e-03	15	75	2	GO:0005005
GeneOntologyBiologicalProcess	regulation of trophoblast cell migration	FBN2 ACVR1B ACVR1C	3.96e-05	19	73	3	GO:1901163
GeneOntologyBiologicalProcess	trophoblast cell migration	FBN2 ACVR1B ACVR1C	4.64e-05	20	73	3	GO:0061450
GeneOntologyCellularComponent	endoplasmic reticulum membrane	ATP8B3 TLCD3B PIGL RAB3GAP1 SGMS2 SPAST PLPP3 ZDHHC16 TMEM97 TMED10 FITM1 TAP1 GPAT4 DHRS7B ADGRG6	4.64e-05	1293	75	15	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	ATP8B3 TLCD3B PIGL RAB3GAP1 SGMS2 SPAST PLPP3 ZDHHC16 TMEM97 TMED10 FITM1 TAP1 GPAT4 DHRS7B ADGRG6	4.90e-05	1299	75	15	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	ATP8B3 TLCD3B PIGL RAB3GAP1 SGMS2 SPAST PLPP3 ZDHHC16 TMEM97 TMED10 FITM1 TAP1 GPAT4 DHRS7B ADGRG6	6.24e-05	1327	75	15	GO:0042175
GeneOntologyCellularComponent	activin receptor complex	ACVR1B ACVR1C	1.89e-04	6	75	2	GO:0048179
Domain	GS	BMPR1B ACVR1B ACVR1C	2.07e-06	7	74	3	SM00467
Domain	GS_dom	BMPR1B ACVR1B ACVR1C	2.07e-06	7	74	3	IPR003605
Domain	GS	BMPR1B ACVR1B ACVR1C	2.07e-06	7	74	3	PS51256
Domain	TGF_beta_GS	BMPR1B ACVR1B ACVR1C	2.07e-06	7	74	3	PF08515
Domain	Activin_recp	BMPR1B ACVR1B ACVR1C	7.02e-06	10	74	3	IPR000472
Domain	Activin_recp	BMPR1B ACVR1B ACVR1C	7.02e-06	10	74	3	PF01064
Domain	TGFB_receptor	BMPR1B ACVR1B ACVR1C	1.28e-05	12	74	3	IPR000333
Domain	CECR6_TMEM121	TMEM121B TMEM121	1.55e-05	2	74	2	PF14997
Domain	CECR6/TMEM121	TMEM121B TMEM121	1.55e-05	2	74	2	IPR032776
Domain	Adaptor_Cbl_EF_hand-like	CBLC CBL	4.63e-05	3	74	2	IPR014741
Domain	Adaptor_Cbl_SH2-like	CBLC CBL	4.63e-05	3	74	2	IPR014742
Domain	Cbl_N2	CBLC CBL	4.63e-05	3	74	2	PF02761
Domain	Cbl_N3	CBLC CBL	4.63e-05	3	74	2	PF02762
Domain	Cbl_N	CBLC CBL	4.63e-05	3	74	2	PF02262
Domain	Adaptor_Cbl_N_hlx	CBLC CBL	4.63e-05	3	74	2	IPR003153
Domain	CBL_PTB	CBLC CBL	4.63e-05	3	74	2	PS51506
Domain	Adaptor_Cbl	CBLC CBL	4.63e-05	3	74	2	IPR024162
Domain	Cbl_PTB	CBLC CBL	4.63e-05	3	74	2	IPR024159
Domain	-	CBLC CBL	4.63e-05	3	74	2	1.20.930.20
Domain	Melatonin_rcpt	GPR50 MTNR1B	4.63e-05	3	74	2	IPR000025
Domain	MYTH4	PLEKHH1 MYO15A	5.48e-04	9	74	2	PS51016
Domain	MyTH4_dom	PLEKHH1 MYO15A	5.48e-04	9	74	2	IPR000857
Domain	MyTH4	PLEKHH1 MYO15A	5.48e-04	9	74	2	PF00784
Domain	MyTH4	PLEKHH1 MYO15A	5.48e-04	9	74	2	SM00139
Domain	Ion_trans_dom	CACNA1E TRPM7 CNGB3 KCNMA1	1.09e-03	114	74	4	IPR005821
Domain	Ion_trans	CACNA1E TRPM7 CNGB3 KCNMA1	1.09e-03	114	74	4	PF00520
Domain	RECEPTOR_TYR_KIN_V_2	EPHA6 EPHA7	1.37e-03	14	74	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA6 EPHA7	1.37e-03	14	74	2	PS00790
Domain	Eph_TM	EPHA6 EPHA7	1.37e-03	14	74	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHA6 EPHA7	1.37e-03	14	74	2	IPR001426
Domain	EPH_lbd	EPHA6 EPHA7	1.37e-03	14	74	2	SM00615
Domain	Ephrin_lbd	EPHA6 EPHA7	1.37e-03	14	74	2	PF01404
Domain	EphA2_TM	EPHA6 EPHA7	1.37e-03	14	74	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA6 EPHA7	1.37e-03	14	74	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHA6 EPHA7	1.37e-03	14	74	2	IPR001090
Domain	EPH_LBD	EPHA6 EPHA7	1.37e-03	14	74	2	PS51550
Domain	Pkinase_Tyr	BMPR1B EPHA6 ACVR1C EPHA7	1.72e-03	129	74	4	PF07714
Domain	MFS_dom	SLC22A9 SV2C MFSD13A SLC22A20P	1.98e-03	134	74	4	IPR020846
Domain	Aa_trans	SLC38A7 SLC38A6	2.03e-03	17	74	2	PF01490
Domain	AA_transpt_TM	SLC38A7 SLC38A6	2.03e-03	17	74	2	IPR013057
Domain	Ser-Thr/Tyr_kinase_cat_dom	BMPR1B EPHA6 ACVR1C EPHA7	2.20e-03	138	74	4	IPR001245
Domain	P_Acid_Pase_2/haloperoxidase	SGMS2 PLPP3	2.81e-03	20	74	2	IPR000326
Domain	PAP2	SGMS2 PLPP3	2.81e-03	20	74	2	PF01569
Domain	-	MCPH1 DBF4B	3.71e-03	23	74	2	3.40.50.10190
Domain	fn3	FNDC1 EPHA6 IL2RG EPHA7	3.92e-03	162	74	4	PF00041
Domain	Ephrin_rec_like	EPHA6 EPHA7	4.38e-03	25	74	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA6 EPHA7	4.38e-03	25	74	2	IPR011641
Domain	BRCT	MCPH1 DBF4B	4.73e-03	26	74	2	PS50172
Domain	GPCR_Rhodpsn_7TM	GPR161 GPR50 HTR6 GPR153 OR6C76 OR52E6 MTNR1B S1PR4	4.93e-03	670	74	8	IPR017452
Domain	7tm_1	GPR161 GPR50 HTR6 GPR153 OR6C76 OR52E6 MTNR1B S1PR4	5.25e-03	677	74	8	PF00001
Domain	BRCT_dom	MCPH1 DBF4B	5.48e-03	28	74	2	IPR001357
Domain	Kinase-like_dom	BMPR1B GAK EPHA6 TRPM7 ACVR1B ACVR1C EPHA7	5.61e-03	542	74	7	IPR011009
Domain	G_PROTEIN_RECEP_F1_1	GPR161 GPR50 HTR6 GPR153 OR6C76 OR52E6 MTNR1B S1PR4	5.62e-03	685	74	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR161 GPR50 HTR6 GPR153 OR6C76 OR52E6 MTNR1B S1PR4	5.92e-03	691	74	8	PS50262
Domain	GPCR_Rhodpsn	GPR161 GPR50 HTR6 GPR153 OR6C76 OR52E6 MTNR1B S1PR4	5.97e-03	692	74	8	IPR000276
Domain	FN3	FNDC1 EPHA6 IL2RG EPHA7	6.25e-03	185	74	4	SM00060
Pathway	WP_SMALL_LIGAND_GPCRS	GPR50 MTNR1B S1PR4	5.50e-05	19	56	3	M39728
Pubmed	CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2.	CBLC CBL	4.84e-06	2	77	2	22315494
Pubmed	Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.	MCPH1 IL2RG	4.84e-06	2	77	2	19487422
Pubmed	Cloning of a melatonin-related receptor from human pituitary.	GPR50 MTNR1B	4.84e-06	2	77	2	8647286
Pubmed	Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.	ACVR1B ACVR1C	1.45e-05	3	77	2	22056140
Pubmed	HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.	MCPH1 IL2RG	1.45e-05	3	77	2	21521873
Pubmed	Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice.	MCPH1 IL2RG	1.45e-05	3	77	2	23833235
Pubmed	C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus.	CBLC CBL	1.45e-05	3	77	2	11850825
Pubmed	Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.	CBLC CBL	1.45e-05	3	77	2	15265912
Pubmed	KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection.	MCPH1 IL2RG	1.45e-05	3	77	2	33951431
Pubmed	Skin-Grafting and Dendritic Cell "Boosted" Humanized Mouse Models Allow the Pre-Clinical Evaluation of Therapeutic Cancer Vaccines.	MCPH1 IL2RG	1.45e-05	3	77	2	37626903
Pubmed	Exopolysaccharide-Treated Dendritic Cells Effectively Ameliorate Acute Graft-versus-Host Disease.	MCPH1 IL2RG	1.45e-05	3	77	2	37924979
Pubmed	Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.	GPR50 MTNR1B	1.45e-05	3	77	2	20733416
Pubmed	ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse.	ACVR1B ACVR1C	1.45e-05	3	77	2	15485907
Pubmed	Loss of function Cbl-c mutations in solid tumors.	CBLC CBL	1.45e-05	3	77	2	31260484
Pubmed	Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations.	GPR50 MTNR1B	1.45e-05	3	77	2	20050988
Pubmed	Activin isoforms signal through type I receptor serine/threonine kinase ALK7.	ACVR1B ACVR1C	1.45e-05	3	77	2	15196700
Pubmed	Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.	CBLC CBL	1.45e-05	3	77	2	12226085
Pubmed	Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies.	MCPH1 IL2RG	1.45e-05	3	77	2	32142680
Pubmed	Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.	GPR50 MTNR1B	1.45e-05	3	77	2	20657642
Pubmed	NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients.	ACVR1B ACVR1C	2.89e-05	4	77	2	26289399
Pubmed	Changes in melatonin receptor expression in a murine model of glaucoma.	GPR50 MTNR1B	2.89e-05	4	77	2	32818016
Pubmed	Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia.	ACVR1B ACVR1C	2.89e-05	4	77	2	21356369
Pubmed	Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A.	CBLC CBL	2.89e-05	4	77	2	24466333
Pubmed	Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression.	IL2RG TAP1	2.89e-05	4	77	2	17940219
Pubmed	Antigen-guided depletion of anti-HLA antibody-producing cells by HLA-Fc fusion proteins.	MCPH1 IL2RG	2.89e-05	4	77	2	36070233
Pubmed	Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.	IL2RG TAP1	2.89e-05	4	77	2	24209604
Pubmed	Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.	CBL IL2RG	2.89e-05	4	77	2	20805496
Pubmed	Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III.	SPAST GPAT4	2.89e-05	4	77	2	31227594
Pubmed	Mutation screening of melatonin-related genes in patients with autism spectrum disorders.	GPR50 MTNR1B	4.82e-05	5	77	2	20377855
Pubmed	Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding.	CBLC CBL	4.82e-05	5	77	2	19380812
Pubmed	Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.	SGCG PCNX1	4.82e-05	5	77	2	22004471
Pubmed	Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.	CBLC CBL	4.82e-05	5	77	2	12024036
Pubmed	c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.	CBLC CBL	4.82e-05	5	77	2	19641021
Pubmed	Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors.	BMPR1B ACVR1B	4.82e-05	5	77	2	8612709
Pubmed	Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses.	MCPH1 IL2RG	4.82e-05	5	77	2	30487575
Pubmed	Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.	CBLC CBL	4.82e-05	5	77	2	15117950
Pubmed	β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.	IL2RG TAP1	4.82e-05	5	77	2	36868208
Pubmed	cbl-b inhibits epidermal growth factor receptor signaling.	CBLC CBL	7.22e-05	6	77	2	10086340
Pubmed	An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.	CBLC CBL	7.22e-05	6	77	2	30118682
Pubmed	Functional activity of serotoninergic and melatoninergic systems expressed in the skin.	GPR50 MTNR1B	7.22e-05	6	77	2	12767050
Pubmed	Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice.	CACNA1E EPHA6	7.22e-05	6	77	2	16910173
Pubmed	Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.	EPHA6 EPHA7	7.22e-05	6	77	2	15996548
Pubmed	c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination.	CBLC CBL	1.01e-04	7	77	2	12244174
Pubmed	Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.	CBLC CBL	1.01e-04	7	77	2	12234920
Pubmed	SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.	BMPR1B ACVR1B	1.01e-04	7	77	2	12065756
Pubmed	The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.	CBLC CBL	1.01e-04	7	77	2	12842890
Pubmed	Glial TLR2-driven innate immune responses and CD8+ T cell activation against brain tumor.	IL2RG TAP1	1.01e-04	7	77	2	30720218
Pubmed	The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.	GPR50 MTNR1B	1.01e-04	7	77	2	16778767
Pubmed	Humanized mice in translational biomedical research.	MCPH1 IL2RG	1.01e-04	7	77	2	17259968
Pubmed	Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.	CBLC CBL	1.01e-04	7	77	2	22888118
Pubmed	A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.	FBN2 TMEM121B PCNX1	1.21e-04	43	77	3	25130324
Pubmed	Mistargeting hippocampal axons by expression of a truncated Eph receptor.	EPHA6 EPHA7	1.34e-04	8	77	2	12124402
Pubmed	Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.	EPHA6 EPHA7	1.34e-04	8	77	2	10774725
Pubmed	Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.	SLC22A9 SLC22A20P	1.34e-04	8	77	2	17714910
Pubmed	Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis.	ACVR1B ACVR1C	1.34e-04	8	77	2	16845371
Pubmed	Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.	CBLC CBL	1.34e-04	8	77	2	14661060
Pubmed	Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1.	IL2RG TAP1	1.34e-04	8	77	2	12634786
Pubmed	Response to Listeria monocytogenes in mice lacking MHC class Ia molecules.	KCNMA1 TAP1	1.72e-04	9	77	2	10228021
Pubmed	CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.	CBLC CBL	1.72e-04	9	77	2	12177062
Pubmed	Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads.	BMPR1B ACVR1B	1.72e-04	9	77	2	12857866
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA6 EPHA7	2.15e-04	10	77	2	25073978
Pubmed	Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.	BMPR1B ACVR1B	2.15e-04	10	77	2	15611116
Pubmed	Quantitative assessment of computational models for retinotopic map formation.	EPHA6 EPHA7	2.15e-04	10	77	2	25367067
Pubmed	EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain.	EPHA6 EPHA7	2.15e-04	10	77	2	28197551
Pubmed	HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.	EPHA6 EPHA7	2.15e-04	10	77	2	17304517
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA6 EPHA7	2.15e-04	10	77	2	16547242
Pubmed	Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).	BMPR1B ACVR1B	2.15e-04	10	77	2	11266516
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	BMPR1B ACVR1B ACVR1C	2.52e-04	55	77	3	15342483
Pubmed	Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy.	MCPH1 IL2RG	2.63e-04	11	77	2	38518774
Pubmed	Competition is a driving force in topographic mapping.	EPHA6 EPHA7	2.63e-04	11	77	2	22065784
Pubmed	Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.	BMPR1B ACVR1B	2.63e-04	11	77	2	7791754
Pubmed	Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5.	EPHA6 EPHA7	2.63e-04	11	77	2	10559410
Pubmed	Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.	BMPR1B ACVR1B	2.63e-04	11	77	2	19758997
Pubmed	Synergistic interaction between Gdf1 and Nodal during anterior axis development.	ACVR1B ACVR1C	3.15e-04	12	77	2	16564040
Pubmed	Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.	BMPR1B ACVR1B	3.15e-04	12	77	2	25872870
Pubmed	Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.	ACVR1B ACVR1C	3.15e-04	12	77	2	23342175
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FBN2 IPO8 TMEM97 TMED10 CBL TAP1 VIRMA PLRG1 GPAT4 GTF3C4	3.16e-04	1203	77	10	29180619
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EPHA6 EPHA7	3.71e-04	13	77	2	17039519
Pubmed	Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.	SLC22A9 SLC22A20P	3.71e-04	13	77	2	15369770
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EPHA6 EPHA7	3.71e-04	13	77	2	12528186
Pubmed	Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice.	IL2RG TAP1	3.71e-04	13	77	2	23006848
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PLEKHH1 BMPR1B EPHA6 MCPH1 SEL1L3 KCNMA1 NLRC5 ZRANB1 TMEM181 DHRS7B ADGRG6	4.25e-04	1489	77	11	28611215
Pubmed	The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.	BMPR1B GPR50	4.33e-04	14	77	2	21549111
Pubmed	TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.	BMPR1B ACVR1B	4.33e-04	14	77	2	21791611
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHA6 EPHA7	4.33e-04	14	77	2	26941654
Pubmed	A role for the EphA family in the topographic targeting of vomeronasal axons.	EPHA6 EPHA7	4.33e-04	14	77	2	11222144
Pubmed	Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.	SLC38A7 SLC38A6	4.99e-04	15	77	2	23506890
Pubmed	Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.	BMPR1B ACVR1B	5.69e-04	16	77	2	11279102
Pubmed	Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.	EPHA6 EPHA7	5.69e-04	16	77	2	8755474
Pubmed	Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.	SLC22A9 SLC10A2	5.69e-04	16	77	2	19679677
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	SPAST CBL PLRG1 GTF3C4	6.03e-04	173	77	4	31470122
Pubmed	The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.	PLPP3 TRPM7 TAP1 GPAT4	6.43e-04	176	77	4	28692057
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHA6 EPHA7	6.44e-04	17	77	2	12217323
Pubmed	Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.	SFI1 ACVR1B	7.23e-04	18	77	2	24939585
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR161 GPR153 MTNR1B	7.31e-04	79	77	3	12679517
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	CBLC CBL	8.07e-04	19	77	2	31959764
Pubmed	Expression of Ephs and ephrins in developing mouse inner ear.	EPHA6 EPHA7	8.07e-04	19	77	2	12684176
Pubmed	Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.	GAK TMED10 DHRS7B	9.36e-04	86	77	3	25044020
Pubmed	Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.	EPHA6 EPHA7	9.89e-04	21	77	2	9267020
Pubmed	Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.	EPHA6 EPHA7	9.89e-04	21	77	2	10495276
Interaction	EFNA5 interactions	GPR161 SLC10A2 EPHA6 BEST2 TAP1 EPHA7	1.82e-07	68	74	6	int:EFNA5
GeneFamily	Type 1 receptor serine/threonine kinases	BMPR1B ACVR1B ACVR1C	9.24e-07	7	55	3	345
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA6 EPHA7	8.08e-04	14	55	2	1095
GeneFamily	Fibronectin type III domain containing	FNDC1 EPHA6 IL2RG EPHA7	1.42e-03	160	55	4	555
GeneFamily	G protein-coupled receptors, Class A orphans	GPR161 GPR50 GPR153	1.72e-03	78	55	3	262
Drug	Acemetacin [53164-05-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	PLPP3 DYNC2H1 SGCG CNGB3 PCNX1 SFI1 MFSD13A	4.25e-06	194	77	7	7442_UP
Disease	Fanconi anemia (implicated_via_orthology)	FANCL FAN1	1.63e-04	8	72	2	DOID:13636 (implicated_via_orthology)
Disease	factor VIII measurement, coronary artery disease	PLPP3 DYNC2H1 HHIPL1 GTF3C4	1.72e-04	113	72	4	EFO_0001645, EFO_0004630
Disease	Heschl's gyrus morphology measurement	FBN2 TMEM121B PCNX1	2.99e-04	53	72	3	EFO_0005852
Disease	breastfeeding duration	FBN2 TMEM181	5.24e-04	14	72	2	EFO_0006864
Disease	wheezing	PLPP3 SV2C CBL	5.46e-04	65	72	3	EFO_0009715
Disease	Phenyllactate (PLA) measurement	IPO8 SLC38A7	9.77e-04	19	72	2	EFO_0021662
Disease	initial pursuit acceleration	IPO8 KCNMA1 EPHA7	1.27e-03	87	72	3	EFO_0008434
Disease	Agents acting on the renin-angiotensin system use measurement	TLCD3B TICRR FBN2 PLPP3 PCNX1	1.38e-03	335	72	5	EFO_0009931
Disease	pulse pressure measurement	FNDC1 BMPR1B FBN2 PLPP3 TRPM7 DYNC2H1 MTNR1B SLC38A7 HHIPL1 LDAH	1.97e-03	1392	72	10	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSIYKLLWRELLCFL	BEST2	26	Q8NFU1
NALYGRWVLARGLCL	HTR6	86	P50406
LGVCRTHRLAEIIYW	ADM5	41	C9JUS6
YIFRPSCTRLGQWAI	CBLC	261	Q9ULV8
LLRQGYTIRILLWTF	CACNA1E	1586	Q15878
YIRRYILKFCIIGWG	ADGRG6	966	Q86SQ4
CWYANGAARLTALRI	ACVR1B	476	P36896
IYSVGLVYWEIARRC	ACVR1C	391	Q8NER5
CFLQRLLLVHGRWSY	ATP8B3	976	O60423
LEWLSFLCRYVPVGL	DUS3L	576	Q96G46
YSFGLILWEVARRCV	BMPR1B	401	O00238
HCLVRWYGLREFVVI	RAB3GAP1	116	Q15042
NVLLGIARGCWVLSY	MCPH1	696	Q8NEM0
SVYLNRSWLGLRFLR	KCNMA1	261	Q12791
WALEGNLARFCRYLS	HHIPL1	136	Q96JK4
SCQRGWRLLYIVTAY	MYO15A	3131	Q9UKN7
LPIAVVSFCYLRIWV	MTNR1B	211	P49286
LLIVGFCYVRIWTKV	GPR50	201	Q13585
GISRESFCVIYLNWI	PCNX1	1756	Q96RV3
LYRVISGHLGWVRCI	PLRG1	196	O43660
RILYAVFCLPSWEAR	OR52E6	221	Q96RD3
LLLPVFLWACDRYRA	GPR153	291	Q6NV75
IILCYIWLLRFAHTG	EPHA7	11	Q15375
RICYQLIISSWLAGF	OR6C76	136	A6NM76
GLVRCFSTLQWLFRL	NLRC5	1051	Q86WI3
IWALGCILYLLCFRQ	GAK	246	O14976
PCILTQWVLGLFRYD	DYNC2H1	2496	Q8NCM8
IGIFVLLWCLYRRAA	GFY	421	I3L273
TVLWGLGVLIRYCFL	GPAT4	161	Q86UL3
CLRRLYHAWLAAVVI	FITM1	51	A5D6W6
LGYLYLLLTQSLWCR	DBF4B	541	Q8NFT6
WYRKFVGVVLCNSLR	FNDC1	1791	Q4ZHG4
GLIISLLCVYFWLER	IL2RG	271	P31785
GVVWCNFSALLYLLI	GPR161	96	Q8N6U8
YIFRLSCTRLGQWAI	CBL	291	P22681
CLGVFGLFRLLQWVR	DHRS7B	31	Q6IAN0
RLCLQLYFLWLGCVV	FBN2	6	P35556
GVAYLIRPWRCLQFA	SLC22A20P	241	A6NK97
RVYGFIGLCWLLAAL	S1PR4	161	O95977
CRRWGVYAVVRGLFL	MFSD13A	326	Q14CX5
LGIYRRCWLVFRKSS	DOK4	21	Q8TEW6
VKGIRWSVYLVNFRC	PATE1	101	Q8WXA2
RIAGLPWYRCRTVAF	SLC10A2	246	Q12908
TLFFLITGRCQWYIK	EPHA6	566	Q9UF33
LLSNLGYLRARSCWV	IPO8	466	O15397
FLRCFTVGWIYTRIL	FAN1	656	Q9Y2M0
LRIRCVARKFLYLWI	SFI1	86	A8K8P3
DLARRYLGVNCVWRY	SEL1L3	921	Q68CR1
CFVRIRTELYGIWLT	SV2C	406	Q496J9
PRFWIAIAAYLACVL	RHBDL2	276	Q9NX52
CRWGYQALSVVLLLA	TMEM121B	196	Q9BXQ6
ICLYEWLRGLLTSRQ	FANCL	336	Q9NW38
VLGLARLRHWVYLLC	PIGL	61	Q9Y2B2
VLYLQARFTWRGARL	PLPP3	211	O14495
GRRFVLRWCYLQVAI	SLC22A9	171	Q8IVM8
RYWYLDGQTLLIIIC	SLC38A6	161	Q8IZM9
FCGRAVVEGLWLRYQ	SLC38A7	341	Q9NVC3
ENLSLFLWYLVRGLC	TAP1	301	Q03518
LGLLFVWLCQRFSRA	SPAST	71	Q9UBP0
WLFLRYKSIVGRRFC	SGMS2	146	Q8NHU3
IGIYGWRKRCLYLFV	SGCG	26	Q13326
RCYYWAVRTLITIGG	CNGB3	396	Q9NQW8
LTYLSCRFGLARVHW	TICRR	31	Q7Z2Z1
CLIGLATWQVFYLRR	TMED10	196	P49755
LLLFWLCVYHGIRVQ	TMEM181	391	Q9P2C4
VRPLVYTLRCWAQGR	TUT1	406	Q9H6E5
CFLLVLRYVAVWVGA	TMEM121	51	Q9BTD3
TRRCVEWLLGLYFLS	TMEM97	6	Q5BJF2
VVAARGSYVFWCLLL	GTF3C4	391	Q9UKN8
CIRIYLTVARKWPFF	PLEKHH1	1211	Q9ULM0
VQRWRYGKVCLRSLL	ZDHHC16	36	Q969W1
LLAPQLYWFFLICRG	TLCD3B	241	Q71RH2
LVLRGWYNCLTLAIY	VIRMA	111	Q69YN4
CLLGYIGIHNEIRWL	TSPAN19	71	P0C672
GRLIYCLNIIFWYVR	TRPM7	961	Q96QT4
RLYALWNRTAGDCLL	ZRANB1	431	Q9UGI0
GRIATPLLCWFRYVL	LDAH	176	Q9H6V9