Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cell-matrix adhesion	TRIP6 TLN1 PKHD1 ACTN3 VWA2 TNXB EMILIN1 FREM1 VCL	2.77e-06	270	90	9	GO:0007160
GeneOntologyCellularComponent	anchoring junction	EPPK1 RPGRIP1L HMCN1 TRIP6 XIRP2 CDHR2 TLN1 OBSCN ACTN3 MAP2K2 PRX VCL PDZD2	2.41e-04	976	89	13	GO:0070161
GeneOntologyCellularComponent	supramolecular fiber	KRT7 EPPK1 RPGRIP1L XIRP2 MICAL2 TTLL11 OBSCN ACTN3 MAP2K2 DNAH5 EML3 DYNC1I2 RYR1 VCL	4.40e-04	1179	89	14	GO:0099512
GeneOntologyCellularComponent	Z disc	XIRP2 OBSCN ACTN3 RYR1 VCL	4.69e-04	151	89	5	GO:0030018
GeneOntologyCellularComponent	supramolecular polymer	KRT7 EPPK1 RPGRIP1L XIRP2 MICAL2 TTLL11 OBSCN ACTN3 MAP2K2 DNAH5 EML3 DYNC1I2 RYR1 VCL	4.71e-04	1187	89	14	GO:0099081
GeneOntologyCellularComponent	cell-substrate junction	EPPK1 HMCN1 TRIP6 XIRP2 TLN1 ACTN3 MAP2K2 VCL	6.03e-04	443	89	8	GO:0030055
GeneOntologyCellularComponent	I band	XIRP2 OBSCN ACTN3 RYR1 VCL	7.21e-04	166	89	5	GO:0031674
GeneOntologyCellularComponent	chaperonin-containing T-complex	CCT8L2 CCT8L1P	9.62e-04	11	89	2	GO:0005832
GeneOntologyCellularComponent	outer dynein arm	DNAH5 DYNC1I2	1.15e-03	12	89	2	GO:0036157
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KRT7 EPPK1 RPGRIP1L MICAL2 TTLL11 ACTN3 MAP2K2 DNAH5 EML3 DYNC1I2 VCL	1.50e-03	899	89	11	GO:0099513
Domain	-	PM20D1 PM20D2	2.22e-04	5	89	2	3.30.70.360
Domain	M20_dimer	PM20D1 PM20D2	2.22e-04	5	89	2	PF07687
Domain	Peptidase_M20_dimer	PM20D1 PM20D2	2.22e-04	5	89	2	IPR011650
Domain	Peptidase_M20	PM20D1 PM20D2	2.22e-04	5	89	2	PF01546
Domain	Peptidase_M20	PM20D1 PM20D2	2.22e-04	5	89	2	IPR002933
Domain	Vinculin/catenin	TLN1 VCL	4.64e-04	7	89	2	IPR006077
Domain	ApoL	APOL1 APOL2	4.64e-04	7	89	2	PF05461
Domain	ApoL	APOL1 APOL2	4.64e-04	7	89	2	IPR008405
Domain	Calx_beta	ADGRV1 FREM1	7.91e-04	9	89	2	IPR003644
Domain	Calx-beta	ADGRV1 FREM1	7.91e-04	9	89	2	PF03160
Domain	CYTOCHROME_B5_2	HERC2 CYB5A	1.69e-03	13	89	2	PS50255
Domain	CYTOCHROME_B5_1	HERC2 CYB5A	1.69e-03	13	89	2	PS00191
Domain	Cyt-b5	HERC2 CYB5A	1.97e-03	14	89	2	PF00173
Domain	GROEL-like_equatorial	HSPD1 CCT8L2	1.97e-03	14	89	2	IPR027413
Domain	-	HERC2 CYB5A	1.97e-03	14	89	2	3.10.120.10
Domain	-	HSPD1 CCT8L2	1.97e-03	14	89	2	1.10.560.10
Domain	Cyt_B5-like_heme/steroid-bd	HERC2 CYB5A	1.97e-03	14	89	2	IPR001199
Domain	Cyt-b5	HERC2 CYB5A	1.97e-03	14	89	2	SM01117
Domain	GroEL-like_apical_dom	HSPD1 CCT8L2	2.26e-03	15	89	2	IPR027409
Domain	Cpn60/TCP-1	HSPD1 CCT8L2	2.26e-03	15	89	2	IPR002423
Domain	Cpn60_TCP1	HSPD1 CCT8L2	2.26e-03	15	89	2	PF00118
Domain	-	HSPD1 CCT8L2	2.26e-03	15	89	2	3.50.7.10
Domain	Cadherin	CDHR2 PCDH8 PCDH20 FREM1	2.45e-03	118	89	4	IPR002126
Domain	EGF	HMCN1 LRP2 VWA2 TNXB	3.10e-03	126	89	4	PF00008
Domain	EF_hand_dom	CAPN12 ANKEF1 ACTN3 RAB11FIP4 RYR1	5.05e-03	232	89	5	IPR002048
Domain	-	COCH HMCN1 VWA2	5.31e-03	74	89	3	3.40.50.410
Pathway	BIOCARTA_INTEGRIN_PATHWAY	TLN1 ACTN3 MAP2K2 VCL	1.52e-05	33	65	4	MM1426
Pathway	BIOCARTA_INTEGRIN_PATHWAY	TLN1 ACTN3 MAP2K2 VCL	1.72e-05	34	65	4	M3342
Pubmed	LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.	HSPD1 KRT7 HMCN1 ACTN3 PHGDH VCL	2.23e-06	142	92	6	30809309
Pubmed	Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.	PRKG1 ACTN3 VCL	3.87e-06	12	92	3	15465019
Pubmed	Vinculin head-tail interaction defines multiple early mechanisms for cell substrate rigidity sensing.	TLN1 VCL	6.92e-06	2	92	2	27169142
Pubmed	Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.	APOL1 APOL2	6.92e-06	2	92	2	34316015
Pubmed	The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.	TLN1 VCL	6.92e-06	2	92	2	16407302
Pubmed	Dystrophin-glycoprotein complex and vinculin-talin-integrin system in human adult cardiac muscle.	TLN1 VCL	6.92e-06	2	92	2	19148538
Pubmed	Vinculins interaction with talin is essential for mammary epithelial differentiation.	TLN1 VCL	6.92e-06	2	92	2	31804547
Pubmed	Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions.	TLN1 VCL	6.92e-06	2	92	2	24452377
Pubmed	Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin.	TLN1 VCL	6.92e-06	2	92	2	15728584
Pubmed	Actomyosin-dependent formation of the mechanosensitive talin-vinculin complex reinforces actin anchoring.	TLN1 VCL	6.92e-06	2	92	2	24452080
Pubmed	Structural basis for amplifying vinculin activation by talin.	TLN1 VCL	6.92e-06	2	92	2	15070891
Pubmed	Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.	TSEN34 HERC2 APOL1 APOL2	1.41e-05	55	92	4	29997285
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	HSPD1 CDHR2 TLN1 PKHD1 LRP2 PM20D1 PBLD ADGRV1 PHGDH RYR1 VCL LGALS3BP	1.54e-05	1016	92	12	19056867
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	HSPD1 RPGRIP1L TRIP6 TLN1 XRN1 LRP2 UNC45A HERC2 HSD17B4 DYNC1I2 VCL	1.60e-05	853	92	11	28718761
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	EPPK1 TLN1 PKHD1 LRP2 DNAH5 RYR1	1.98e-05	208	92	6	33230847
Pubmed	Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs.	APOL1 APOL2	2.07e-05	3	92	2	15949655
Pubmed	RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.	TLN1 VCL	2.07e-05	3	92	2	23389036
Pubmed	The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.	TLN1 VCL	2.07e-05	3	92	2	16407299
Pubmed	WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.	TLN1 VCL	2.07e-05	3	92	2	17591693
Pubmed	Central region of talin has a unique fold that binds vinculin and actin.	TLN1 VCL	2.07e-05	3	92	2	20610383
Pubmed	ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.	LRP2 DYNC1I2	2.07e-05	3	92	2	23836931
Pubmed	Vinculin and talin: focus on the myocardium.	TLN1 VCL	2.07e-05	3	92	2	19952892
Pubmed	Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia.	APOL1 APOL2	2.07e-05	3	92	2	18632255
Pubmed	Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses.	TLN1 VCL	2.07e-05	3	92	2	26923917
Pubmed	Three new single nucleotide polymorphisms identified by a genome-wide association study in Korean patients with vitiligo.	RPGRIP1L DNAH5	2.07e-05	3	92	2	23678272
Pubmed	Coupling of β2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis.	TLN1 VCL	2.07e-05	3	92	2	31659275
Pubmed	Increased talin-vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections.	TLN1 VCL	2.07e-05	3	92	2	32238906
Pubmed	Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.	TLN1 VCL	2.07e-05	3	92	2	27816808
Pubmed	Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force.	TLN1 VCL	2.07e-05	3	92	2	32561773
Pubmed	Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.	TLN1 VCL	2.07e-05	3	92	2	15494027
Pubmed	Vinculin controls talin engagement with the actomyosin machinery.	TLN1 VCL	2.07e-05	3	92	2	26634421
Pubmed	Focal adhesion proteins talin-1 and vinculin negatively affect paxillin phosphorylation and limit retroviral infection.	TLN1 VCL	2.07e-05	3	92	2	21763488
Pubmed	Vinculin controls focal adhesion formation by direct interactions with talin and actin.	TLN1 VCL	2.07e-05	3	92	2	18056416
Pubmed	Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.	KRT7 PKHD1	2.07e-05	3	92	2	18235088
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PRPSAP2 KRT7 RPGRIP1L TTLL11 TRIM56 DUSP5 SLC5A7 UBA2 EEF1AKMT1 APOL1 APOL2 MAP2K2 DYNC1I2	2.35e-05	1242	92	13	30973865
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	KRT7 HMCN1 CDHR2 GGT6 TLN1 LRP2 PBLD ACTN3 TNXB PHGDH LGALS3BP BHMT	2.55e-05	1070	92	12	23533145
Pubmed	Global landscape of HIV-human protein complexes.	SEPSECS EPPK1 PLAA UNC45A HERC2 EML3 DYNC1I2 LGALS3BP	2.97e-05	457	92	8	22190034
Pubmed	Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks.	TLN1 VCL	4.14e-05	4	92	2	10320340
Pubmed	Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly.	TLN1 VCL	4.14e-05	4	92	2	16000373
Pubmed	Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation.	TLN1 VCL	4.14e-05	4	92	2	20308429
Pubmed	Mouse Apolipoprotein L9 is a phosphatidylethanolamine-binding protein.	APOL1 APOL2	4.14e-05	4	92	2	27697524
Pubmed	Recent progress in protocadherin research.	CDHR2 PCDH20	4.14e-05	4	92	2	11082270
Pubmed	Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.	APOL1 APOL2	4.14e-05	4	92	2	11290834
Pubmed	Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.	PRKG1 RYR1	4.14e-05	4	92	2	8380342
Pubmed	The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.	APOL1 APOL2	4.14e-05	4	92	2	11944986
Pubmed	Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins.	TLN1 VCL	4.14e-05	4	92	2	9054445
Pubmed	Vinculin regulates assembly of talin: β3 integrin complexes.	TLN1 VCL	4.14e-05	4	92	2	24446374
Pubmed	Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.	PRKG1 RYR1	4.14e-05	4	92	2	14532276
Pubmed	Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.	PRKG1 PCDH20	4.14e-05	4	92	2	21907864
Pubmed	Structural dynamics of alpha-actinin-vinculin interactions.	TLN1 VCL	4.14e-05	4	92	2	15988023
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	HSPD1 SEPSECS MTMR4 TRIP6 DUSP5 XRN1 TSEN34 UBA2 JMJD4 UNC45A VCL	5.34e-05	974	92	11	28675297
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	XIRP2 TLN1 RETREG1 OBSCN ACTN3 PHGDH RYR1 VCL	5.35e-05	497	92	8	23414517
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	HSPD1 HMCN1 ADGRV1 FREM1 LGALS3BP	5.40e-05	152	92	5	34299191
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	HSPD1 KRT7 EPPK1 ACTN3 UNC45A HSD17B4 PHGDH VCL LGALS3BP	5.56e-05	647	92	9	26618866
Pubmed	Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.	ACTN3 VCL	6.89e-05	5	92	2	21536590
Pubmed	Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes.	PRKG1 VCL	6.89e-05	5	92	2	21451103
Pubmed	The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.	PKHD1 LRP2	6.89e-05	5	92	2	20048263
Pubmed	Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.	TLN1 VCL	6.89e-05	5	92	2	7534286
Pubmed	Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.	EPOR DUSP5 MAP3K6	6.91e-05	30	92	3	17699753
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	HSPD1 UNC45A PHGDH VCL LGALS3BP	8.20e-05	166	92	5	35687106
Pubmed	Differential gene expression during terminal erythroid differentiation.	APOL1 APOL2	1.03e-04	6	92	2	17764892
Pubmed	The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.	APOL1 APOL2	1.03e-04	6	92	2	11374903
Pubmed	Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.	TLN1 VCL	1.03e-04	6	92	2	22925892
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	HSPD1 PRMT6 PLAA TLN1 UBA2 UNC45A HSD17B4 MAP2K2 PHGDH DYNC1I2	1.11e-04	878	92	10	37223481
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	HSPD1 HSD17B4 PHGDH DYNC1I2 VCL	1.26e-04	182	92	5	30711629
Pubmed	Arf4 is required for Mammalian development but dispensable for ciliary assembly.	PKHD1 LRP2	1.44e-04	7	92	2	24586199
Pubmed	Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.	TLN1 VCL	1.44e-04	7	92	2	23266827
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	HSPD1 TLN1 OBSCN SLC5A7 PKHD1 LRP2 CHD6 EEF1AKMT1 RYR1	1.47e-04	736	92	9	29676528
Pubmed	A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.	EPPK1 TLN1 HERC2 PHGDH VCL	1.51e-04	189	92	5	31594818
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	EPPK1 OBSCN PBLD VCL CYB5A BHMT	1.61e-04	304	92	6	32235678
Pubmed	Functional proteomics mapping of a human signaling pathway.	KRT7 MTMR4 IRF2BP1 CHD6 UNC45A HERC2 PPP1R15A VCL	1.77e-04	591	92	8	15231748
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	HSPD1 TLN1 UNC45A APOL2 PHGDH DYNC1I2	1.85e-04	312	92	6	37120454
Pubmed	Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.	OBSCN VCL	1.92e-04	8	92	2	28826662
Pubmed	The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.	TLN1 ACTN3	1.92e-04	8	92	2	11381084
Pubmed	β2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages.	TLN1 VCL	1.92e-04	8	92	2	22017400
Pubmed	beta-Dystroglycan modulates the interplay between actin and microtubules in human-adhered platelets.	TLN1 VCL	1.92e-04	8	92	2	18341635
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HSPD1 PLAA TRIP6 UTP15 MICAL2 TLN1 XRN1 UNC45A HERC2 PHGDH DYNC1I2 VCL	2.35e-04	1353	92	12	29467282
Pubmed	Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.	DNAH5 DYNC1I2	2.46e-04	9	92	2	27353389
Pubmed	Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.	TLN1 VCL	2.46e-04	9	92	2	11807098
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	PRPSAP2 DUSP5 OBSCN DNAH5 RYR1	2.68e-04	214	92	5	22199357
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	TLN1 EMILIN1 LGALS3BP	3.02e-04	49	92	3	21362503
Pubmed	Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.	TLN1 VCL	3.07e-04	10	92	2	11113628
Pubmed	Assembly of the cochlear gap junction macromolecular complex requires connexin 26.	TLN1 VCL	3.07e-04	10	92	2	24590285
Pubmed	Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes.	HSPD1 CCT8L2 CCT8L1P	3.60e-04	52	92	3	20193073
Pubmed	Identification of a candidate gene for astigmatism.	CHSY1 DNAH5	3.75e-04	11	92	2	23322567
Pubmed	PEX14 is required for microtubule-based peroxisome motility in human cells.	HSD17B4 MAP2K2 DYNC1I2	4.03e-04	54	92	3	21525035
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	KRT7 PLAA TLN1 UNC45A ARMC6	4.12e-04	235	92	5	28378594
Pubmed	Strain-specific modifier genes governing craniofacial phenotypes.	B3GALT6 PHGDH	4.49e-04	12	92	2	22371338
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	HSPD1 PRMT6 PRPSAP2 KRT7 PLAA TRIP6 TLN1 TSEN34 UBA2 UNC45A DYNC1I2 VCL	4.52e-04	1455	92	12	22863883
Pubmed	Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.	HSD17B4 PHGDH DYNC1I2	4.73e-04	57	92	3	18781797
Pubmed	Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1).	SLC5A7 RYR1	5.30e-04	13	92	2	30870432
Pubmed	Loss of migfilin expression has no overt consequences on murine development and homeostasis.	TRIP6 VCL	5.30e-04	13	92	2	21224394
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	KRT7 EPPK1 TLN1 XRN1 UNC45A	6.07e-04	256	92	5	33397691
Pubmed	Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.	PHGDH BHMT	6.17e-04	14	92	2	23378610
Pubmed	Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.	TLN1 VCL	6.17e-04	14	92	2	19652092
Pubmed	ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.	APOL1 APOL2	6.17e-04	14	92	2	34380029
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ATP8B4 TTLL11 HERC2 VWA2 TNXB UNC80 RYR1	6.69e-04	552	92	7	10737800
Pubmed	Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function.	HSPD1 VCL	7.11e-04	15	92	2	19725078
Pubmed	Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.	TLN1 VCL	7.11e-04	15	92	2	19793892
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	HERC2 CEP43	8.11e-04	16	92	2	19068216
GeneFamily	Non-clustered protocadherins	PCDH8 PCDH20	7.00e-04	12	60	2	21
GeneFamily	LIM domain containing	TRIP6 XIRP2 MICAL2	9.90e-04	59	60	3	1218
GeneFamily	Apolipoproteins	APOL1 APOL2	2.18e-03	21	60	2	405
GeneFamily	Beta 3-glycosyltransferases	CHSY1 B3GALT6	2.85e-03	24	60	2	426
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 XIRP2 OBSCN PKHD1 LRP2 ADGRV1 DNAH5 UNC80 FREM1	1.54e-10	184	91	9	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 XIRP2 OBSCN PKHD1 LRP2 ADGRV1 DNAH5 UNC80 FREM1	1.54e-10	184	91	9	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 XIRP2 OBSCN PKHD1 LRP2 ADGRV1 DNAH5 UNC80 FREM1	1.54e-10	184	91	9	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 CECR2 PKHD1 LRP2 ADGRV1 UNC80 FREM1	3.97e-08	160	91	7	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 CECR2 PKHD1 LRP2 ADGRV1 UNC80 FREM1	3.97e-08	160	91	7	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 ATP8B4 ASRGL1 PKHD1 LRP2 BHMT PDZD2	7.93e-08	177	91	7	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Club\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	KRT7 GGT6 LRP2 ADGRV1 PCDH20 LGALS3BP CYB5A	1.59e-07	196	91	7	4e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	MTMR4 PM20D1 CHD6 RAB11FIP4 CYB5A BHMT	6.55e-07	150	91	6	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 PKHD1 LRP2 ADGRV1 DNAH5 UNC80	1.32e-06	169	91	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-GAT-Fat-24m-Epithelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 SEPSECS CDHR2 GGT6 OBSCN ADGRV1	1.51e-06	173	91	6	815ba48a9222ea09ba8005e2d2f7c5addf118ad1
ToppCell	facs-GAT-Fat-24m-Epithelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 SEPSECS CDHR2 GGT6 OBSCN ADGRV1	1.51e-06	173	91	6	98e464d9e6d6b69421e9e4041b638b6825247f60
ToppCell	facs-GAT-Fat-24m-Epithelial-epithelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 SEPSECS CDHR2 GGT6 OBSCN ADGRV1	1.51e-06	173	91	6	3e6f0a08eddfd61871f7a85acccf6d539af6ebda
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 PKHD1 LRP2 ADGRV1 UNC80 FREM1	1.61e-06	175	91	6	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 ALLC ATP8B4 LRP2 BHMT PDZD2	1.66e-06	176	91	6	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HSPD1 EPOR GADD45G DUSP5 RETREG1 B3GALT6	2.15e-06	184	91	6	780d67f04fc795f614e077d8a5cf368542f6d99d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 ATP8B4 ASRGL1 LRP2 BHMT PDZD2	2.15e-06	184	91	6	9434731f651820b05335085582960f08fbf895de
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CDHR2 PKHD1 LRP2 CYB5A BHMT PDZD2	2.29e-06	186	91	6	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	COVID-19-kidney-Stressed_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	HSPD1 ATP8B4 CDHR2 LRP2 BHMT PDZD2	2.37e-06	187	91	6	acd305475f3609800af0d7bc68d83ef41228080b
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PI4K2B TRIM56 XRN1 APOL1 APOL2 LGALS3BP	2.44e-06	188	91	6	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	KRT7 MICAL2 ADGRV1 DNAH5 CYB5A PDZD2	2.44e-06	188	91	6	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RETREG1 PKHD1 PRKG1 ADGRV1 VCL PDZD2	2.44e-06	188	91	6	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	GADD45G MICAL2 CECR2 LRP2 ADGRV1 CYB5A	2.52e-06	189	91	6	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	MICAL2 CECR2 LRP2 ADGRV1 CYB5A PDZD2	2.75e-06	192	91	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	MICAL2 PRKG1 ADGRV1 DNAH5 CYB5A PDZD2	2.75e-06	192	91	6	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	MICAL2 CECR2 LRP2 ADGRV1 CYB5A PDZD2	2.84e-06	193	91	6	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	15-Airway-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	KRT7 GGT6 DNAH5 PCDH20 LGALS3BP CYB5A	3.01e-06	195	91	6	cd0af7e260e4f0c5a9ecdfa93619f37b2a9308a5
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT7 MICAL2 PRKG1 ADGRV1 DNAH5 PDZD2	3.01e-06	195	91	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	Mild-CD4+_T_activated\|World / Disease group and Cell class	PI4K2B TRIM56 XRN1 APOL1 APOL2 LGALS3BP	3.10e-06	196	91	6	417b4fc2e4388f34c410576131b02936f93e46b6
ToppCell	Epithelial_cells-Epithelial_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	ASRGL1 GGT6 LRP2 PBLD CYB5A BHMT	3.29e-06	198	91	6	52e9d41a1726bc1140df6baec9f17a534448ac8b
ToppCell	Epithelial_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	ASRGL1 GGT6 LRP2 PBLD CYB5A BHMT	3.29e-06	198	91	6	eeec789d226171f30799577cc37c07bdced2e3cb
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MICAL2 CECR2 LRP2 ADGRV1 CYB5A PDZD2	3.39e-06	199	91	6	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-immature_natural_killer_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CAPN12 ATP8B4 PRKG1 BHMT PDZD2	1.25e-05	146	91	5	40fac8a298152ec7f7eeeed5a2d28541aea3b338
ToppCell	5'-Adult-Appendix-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN12 MCAT ADGRV1 VWA2 DNAH5	2.19e-05	164	91	5	29da0175bd3808a5b3039a6161c764105608ef96
ToppCell	5'-Adult-Appendix-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN12 MCAT ADGRV1 VWA2 DNAH5	2.19e-05	164	91	5	e83b632ac7e1dace946991ddfe1fbfbbffc3a88b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 PBLD RYR1 BHMT PDZD2	2.38e-05	167	91	5	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-1\|TCGA-Uvea / Sample_Type by Project: Shred V9	IRF2BP1 KANK3 TLN1 B3GALT6 EML3	2.45e-05	168	91	5	b427746929bb40e3d1b5f1c40d302b792d6b32a5
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR KRT7 PAX1 BHMT PDZD2	2.52e-05	169	91	5	2d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR KRT7 PAX1 BHMT PDZD2	2.52e-05	169	91	5	ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR KRT7 PAX1 BHMT PDZD2	2.52e-05	169	91	5	ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 EPPK1 TRIP6 PKHD1 DNAH5	2.75e-05	172	91	5	a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 EPPK1 TRIP6 PKHD1 DNAH5	2.75e-05	172	91	5	0a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 CDHR2 DUSP5 OBSCN MAP3K6	2.90e-05	174	91	5	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PI4K2B TRIM56 XRN1 APOL1 LGALS3BP	3.32e-05	179	91	5	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CAPN12 RETREG1 PKHD1 LRP2 BHMT	3.41e-05	180	91	5	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	MICAL2 CECR2 LRP2 ADGRV1 CYB5A	3.41e-05	180	91	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CDHR2 PKHD1 LRP2 PBLD BHMT	3.50e-05	181	91	5	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MXD3 ASRGL1 METRN RETREG1 ADGRV1	3.60e-05	182	91	5	f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 COCH LRP2 ADGRV1 BHMT	3.69e-05	183	91	5	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	TRIM56 XRN1 PPP1R15A APOL1 APOL2	3.69e-05	183	91	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	MICAL2 LRP2 ADGRV1 CYB5A PDZD2	3.79e-05	184	91	5	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	XIRP2 CACTIN-AS1 OBSCN VCL PDZD2	3.79e-05	184	91	5	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	CAPN12 CECR2 ADGRV1 DNAH5 CYB5A	3.89e-05	185	91	5	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ACTN3 TNXB PCDH20 FREM1	3.89e-05	185	91	5	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ACTN3 TNXB PCDH20 FREM1	3.89e-05	185	91	5	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 LRP2 PBLD BHMT PDZD2	3.99e-05	186	91	5	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 ATP8B4 LRP2 BHMT PDZD2	3.99e-05	186	91	5	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 ASRGL1 RETREG1 PKHD1 LRP2	3.99e-05	186	91	5	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MICAL2 PKHD1 LRP2 ADGRV1 VWA2	4.09e-05	187	91	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 LRP2 PBLD BHMT PDZD2	4.09e-05	187	91	5	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PKHD1 ADGRV1 HSD17B4 CYB5A PDZD2	4.09e-05	187	91	5	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PKHD1 LRP2 BHMT PDZD2	4.09e-05	187	91	5	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	HMCN1 PRKG1 TNXB EMILIN1 FREM1	4.09e-05	187	91	5	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PKHD1 LRP2 BHMT PDZD2	4.09e-05	187	91	5	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 LRP2 PBLD BHMT PDZD2	4.20e-05	188	91	5	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KRT7 GGT6 PAX1 DNAH5 CYB5A	4.20e-05	188	91	5	07705bed928683470a52c8ccfa40ffb9a0971318
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GADD45G OBSCN PRKG1 DNAH5 EMILIN1	4.20e-05	188	91	5	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	KRT7 MICAL2 ADGRV1 DNAH5 PDZD2	4.20e-05	188	91	5	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 LRP2 PBLD BHMT PDZD2	4.20e-05	188	91	5	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PKHD1 LRP2 RAB11FIP4 ADGRV1 VWA2	4.31e-05	189	91	5	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	COCH KANK3 DUSP5 TNXB BHMT	4.31e-05	189	91	5	f0418851ad4042c4cd87c8729e4f0d43bdf8fccb
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 RETREG1 PKHD1 VWA2 DNAH5	4.31e-05	189	91	5	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 RETREG1 PKHD1 VWA2 DNAH5	4.31e-05	189	91	5	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	CAPN12 RETREG1 PKHD1 LRP2 BHMT	4.31e-05	189	91	5	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MXD3 PKHD1 LRP2 ADGRV1 VWA2	4.31e-05	189	91	5	c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPOR DUSP5 RETREG1 PRKG1 PDZD2	4.41e-05	190	91	5	979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCell	Calu_3-infected-SARSCoV2\|infected / Cell line, Condition and Strain	TRIM56 XRN1 PPP1R15A APOL1 APOL2	4.53e-05	191	91	5	2da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	XIRP2 TLN1 PRKG1 FREM1 VCL	4.53e-05	191	91	5	7edc22e7e70697fb22690699efb352577162709b
ToppCell	15-Airway-Epithelial-Secretory_progenitor\|Airway / Age, Tissue, Lineage and Cell class	KRT7 GGT6 PCDH20 LGALS3BP CYB5A	4.53e-05	191	91	5	9359d8c6b00f8977848986baf3c950157adf4c9a
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MICAL2 CECR2 ADGRV1 CYB5A PDZD2	4.53e-05	191	91	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	MICAL2 CECR2 ADGRV1 CYB5A PDZD2	4.64e-05	192	91	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	Enterocyte_Progenitors-C_06\|Enterocyte_Progenitors / shred on cell type and cluster	CAPN12 KRT7 ASRGL1 APOL1 LGALS3BP	4.64e-05	192	91	5	b9938e1a929c00628cc6ebfdf10cf285167f445c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	CECR2 LRP2 PRKG1 ADGRV1 DNAH5	4.64e-05	192	91	5	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPOR DUSP5 RETREG1 PRKG1 PDZD2	4.64e-05	192	91	5	063e119c4b58957643908f667e6cfd6f7517fd03
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MICAL2 PKHD1 ADGRV1 CYB5A PDZD2	4.64e-05	192	91	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	Megakaryocytic-erythropoietic-Megakaryo-cells-Megakaryocyte\|World / Lineage, cell class and subclass	XIRP2 TLN1 PRKG1 EMILIN1 VCL	4.76e-05	193	91	5	352cd442b6e62f09b6d22a139774067873644594
ToppCell	ASK440-Epithelial-Secretory\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	KRT7 GGT6 DNAH5 PCDH20 CYB5A	4.76e-05	193	91	5	50e98d91697c7af6a3de39e52edde6dd2b67b512
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	HMCN1 PRKG1 TNXB EMILIN1 FREM1	4.76e-05	193	91	5	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LRP2 RAB11FIP4 APOL2 PCDH20 DYNC1I2	4.76e-05	193	91	5	947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCell	kidney_cells-CKD+DKD_normotensive\|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group	HSPD1 LRP2 PBLD CYB5A BHMT	4.76e-05	193	91	5	522a301bb48a5c40def7e0b58b2a2c13d85ac7a1
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT7 MICAL2 PRKG1 ADGRV1 PDZD2	4.87e-05	194	91	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 KRT7 RETREG1 PKHD1 LRP2	4.87e-05	194	91	5	70185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCell	343B\|World / Donor, Lineage, Cell class and subclass (all cells)	KRT7 LRP2 DNAH5 PHGDH CYB5A	4.99e-05	195	91	5	2290911fde6efacfa38b985a2541322968bee42d
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	HMCN1 PRKG1 TNXB EMILIN1 FREM1	4.99e-05	195	91	5	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	HSPD1 GADD45G DUSP5 PPP1R15A PRX	5.12e-05	196	91	5	d79a84aa25ba70483ae899cd5b52ba0bbffdcd7b
ToppCell	critical-Epithelial-Secretory\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KRT7 ASRGL1 TRIP6 PCDH20 LGALS3BP	5.12e-05	196	91	5	7da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCell	hematopoetic_progenitors-CD34+_MEP_1\|hematopoetic_progenitors / Lineage and Cell class	EPOR GADD45G MICAL2 TLN1 FREM1	5.24e-05	197	91	5	6172a1b98ff840d9174b1ab20ba0c202a7ef87af
ToppCell	AT2_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	HSPD1 KRT7 DUSP5 RETREG1 PHGDH	5.24e-05	197	91	5	c36513e893488c4299119d4fba6ef0fd72610ee6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPD1 LRP2 PBLD CYB5A BHMT	5.24e-05	197	91	5	291458becbf90e9dda22ea069df7f9a45d827bcd
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MXD3 ERICH3 HMCN1 AMIGO3	5.29e-05	100	91	4	cb0deaf1c33d2789417e93cc01d94e34a611d20a
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Radial_glial-oRG\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	METRN TRIP6 ADGRV1 PHGDH LGALS3BP	5.37e-05	198	91	5	72dc49aa107d0cc6206eb67b577c73e190855125
Disease	Pontocerebellar Hypoplasia Type 2	SEPSECS TSEN34	5.50e-05	4	90	2	C2932714
Disease	Pontocerebellar hypoplasia type 2	SEPSECS TSEN34	1.37e-04	6	90	2	cv:C2932714
Disease	stroke, response to clopidogrel, cardiovascular event measurement	MICAL2 PRKG1	1.91e-04	7	90	2	EFO_0000712, EFO_0006919, GO_1903493
Disease	Ciliopathies	RPGRIP1L PKHD1 ADGRV1 DNAH5	3.65e-04	110	90	4	C4277690
Disease	cannabis dependence measurement	PI4K2B PKHD1 PAX1	4.30e-04	48	90	3	EFO_0008457
Disease	cardiac troponin T measurement	CECR2 PKHD1 RAB11FIP4 MAP2K2 VCL	5.67e-04	219	90	5	EFO_0005043
Disease	serum selenium measurement	PKHD1 PRKG1 BHMT	5.76e-04	53	90	3	EFO_0005266
Disease	Astigmatism	CHSY1 CHD6 HERC2 DNAH5	6.66e-04	129	90	4	HP_0000483
Disease	Congenital pontocerebellar hypoplasia	SEPSECS TSEN34	7.02e-04	13	90	2	C0266468
Disease	Hypertrophic Cardiomyopathy	HSPD1 OBSCN VCL	7.13e-04	57	90	3	C0007194
Disease	Pontoneocerebellar hypoplasia	SEPSECS TSEN34	1.07e-03	16	90	2	cv:C1261175
Disease	bipolar disorder, body mass index	RPGRIP1L PKHD1 PDZD2	1.41e-03	72	90	3	EFO_0004340, MONDO_0004985
Disease	social deprivation, COVID-19	CECR2 PCDH20	1.86e-03	21	90	2	EFO_0009696, MONDO_0100096
Disease	apolipoprotein L1 measurement	APOL1 APOL2	2.64e-03	25	90	2	EFO_0021854

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLNAGEIVIGDGGFV	BHMT	16	Q93088
GRAEGQGGVDVVLRT	ERICH3	1256	Q5RHP9
VGTAGLGAEERRALE	B3GALT6	96	Q96L58
IGRISAEGGEQVERV	APOL2	246	Q9BQE5
LGIQGVIRGFDVDVS	ALLC	66	Q8N6M5
GILREGGSAVDAVEG	ASRGL1	36	Q7L266
RIIVEGGGAVAALQA	ARMC6	406	Q6NXE6
ISVAGGGRLGDDVVV	ADGRV1	4006	Q8WXG9
GGAQLRSGFIVAEIE	ADGRV1	4986	Q8WXG9
VRGILERGGEVNAFD	ANKEF1	201	Q9NU02
GADISRLAGFDGIVV	ATP8B4	186	Q8TF62
NATRAAVEEGIVLGG	HSPD1	426	P10809
ELDALGRGVFVNASG	AMIGO3	96	Q86WK7
RVEAQDGEILVVGAG	CACTIN-AS1	91	Q8N1I8
GRGALVDEVGVEDVE	CACTIN-AS1	111	Q8N1I8
VADRGALSENGVIGE	CECR2	1066	Q9BXF3
DFERISELGAGNGGV	MAP2K2	71	P36507
RVDIRGGAAVVLEGT	PBLD	271	P30039
VAALGLRFGQGEEVE	RAB11FIP4	41	Q86YS3
QSRGVQLAFIVDEGG	PM20D1	206	Q6GTS8
RAGEGLGLIQEAASV	CT47A1	181	Q5JQC4
GEIGVISVTDADAGR	PCDH20	656	Q8N6Y1
GGEAELLRGFVAGQE	MXD3	181	Q9BW11
LADGGATNQGRVEIF	LGALS3BP	26	Q08380
NIDVFDARADGEGIG	RPGRIP1L	1276	Q68CZ1
GAQVFAERAGGALEL	METRN	91	Q9UJH8
LEGEESRLAGDGVGA	KRT7	396	P08729
ESLRGIEVVDVAAGG	HERC2	4086	O95714
NIIDTLGVGGFGRVE	PRKG1	361	Q13976
SGREIAVGDSEGQIV	DYNC1I2	581	Q13409
RGLADGLVQAGVGTE	MAP3K6	196	O95382
DLVIVGAEGVVENGG	EIF2B1	191	Q14232
VREGDGQLTVGDAGL	PCDH8	76	O95206
GAAEQAGIIEAGDEI	PDZD2	2786	O15018
DNDDIGAVRLVTVGG	FREM1	441	Q5H8C1
GGEEVLREQAGGDAT	CYB5A	46	P00167
EAIAAVGEGGRIACV	EEF1AKMT1	66	Q8WVE0
AVTGRGVIERGNVDG	LRP2	1936	P98164
VLQGEGVEFLGRAAD	MTMR4	36	Q9NYA4
RGSVIGNINDVEFGI	HMCN1	4876	Q96RW7
TVVRGLENVEALEGG	OBSCN	4341	Q5VST9
AVRLLDAAGEEGEAG	PI4K2B	46	Q8TCG2
GAQGVAELLRDATGA	MCAT	31	Q8IVS2
AIGTGRIGGLAEEEA	PAX1	481	P15863
GRVTIQLVDEEAGVG	CAPN12	6	Q6ZSI9
IGADGVIRVNGSLDR	CDHR2	291	Q9BYE9
ARDLGIIEAEGTVGG	CEP43	111	O95684
VDDDGETIAVLGAGR	CHD6	256	Q8TD26
GDVQRLAAIVGAGEE	GADD45G	96	O95257
ERGALVVVNDLGGDF	HSD17B4	31	P51659
RELLVAGGNVVDAGV	GGT6	116	Q6P531
LVLREAAAEDGAGLG	JMJD4	396	Q9H9V9
LGVGVRAEEAGARVQ	APOL1	21	O14791
AGLEQELEAGVGGRF	PRMT6	261	Q96LA8
AGNGAGSVQRVEILE	EPOR	186	P19235
AAGRSEGALQVLDGE	KANK3	276	Q6NY19
VVGDVGGRIAIIVDD	PRPSAP2	256	O60256
QEIGLGAFERGVGAL	EML3	351	Q32P44
EGVCERLDTVAGGLQ	EMILIN1	731	Q9Y6C2
DIEEAGIVAREFGVN	COCH	281	O43405
EGGSGLLAAIEEAIR	RYR1	2371	P21817
LQEGGGGVAAVVVLD	DUSP5	76	Q16690
GGGDETREAVVARLA	DNAH5	4346	Q8TE73
LANGLGREEAVAEGA	IRF2BP1	136	Q8IU81
GEEAAGQDVLAVRVL	MICAL2	1151	O94851
KGAALVEAGLEGEAR	PPP1R15A	51	O75807
EERSEAIIVGGRDIG	SLC5A7	36	Q9GZV3
DGRLLVAGSEDGGVQ	UTP15	91	Q8TED0
EGAGLQVEEAAGRAA	RETREG1	51	Q9H6L5
EAQAATGGLVDLARG	EPPK1	76	P58107
RLSVEEAVAAGVVGG	EPPK1	2816	P58107
RLSVEEAVAAGVVGG	EPPK1	3881	P58107
LAEAVAGGRVLVVGA	UBA2	11	Q9UBT2
AAAGINVAVVLGEVD	CCT8L1P	286	A6NM43
AAAGINVAVVLGEVD	CCT8L2	286	Q96SF2
GNRGLLFEVGDAVEG	PKHD1	326	P08F94
EVGAAAALGVRGALE	PM20D2	131	Q8IYS1
EGGRGLAQAVLEGVA	SLC39A2	251	Q9NP94
EVGRLAAGLAGSLEE	ACTN3	666	Q08043
GDLVRVGGFDVSIQG	CHSY1	701	Q86X52
RGIADQEIIAGGDVK	XIRP2	426	A4UGR9
TVAEQVRVDAGAAGE	TTLL11	126	Q8NHH1
VVGDGAGVVALDRVF	TRIP6	286	Q15654
GEVREDGVAVSAVAQ	UNC80	1861	Q8N2C7
AEAVQALRERLGVGG	TSEN34	16	Q9BSV6
AATEDGQLLRGVGAA	TLN1	756	Q9Y490
LVTLGAQEEGRAEGA	PRX	1101	Q9BXM0
RVRGEESEVTVGGLE	TNXB	2781	P22105
RVRGEESEVTVGGLE	TNXB	3211	P22105
DNGDIVVGASDGIIR	PLAA	281	Q9Y263
DRGVGQAAIRGLVAE	VCL	511	P18206
VVVLTGGRGAEDAAV	VWA2	636	Q5GFL6
GEVQDSGDVITEGRI	XRN1	871	Q8IZH2
QVVGRAGTGVDNVDL	PHGDH	71	O43175
VVNCARGGIVDEGAL	PHGDH	231	O43175
GVGEREGRVASALVA	SEPSECS	71	Q9HD40
EEVEDRGTVVAQGGG	UNC45A	676	Q9H3U1
VGTQVEEAAEGVLRA	TRIM56	251	Q9BRZ2