Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone phosphatase activity	EYA2 EYA3	3.12e-05	3	65	2	GO:0140789
GeneOntologyMolecularFunction	histone H2AXY142 phosphatase activity	EYA2 EYA3	3.12e-05	3	65	2	GO:0140793
GeneOntologyMolecularFunction	phosphorylase kinase activity	PHKA1 PHKA2	6.23e-05	4	65	2	GO:0004689
GeneOntologyMolecularFunction	L-leucine binding	UBR1 UBR2	2.17e-04	7	65	2	GO:0070728
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	UBR1 UBR2 FBXO10 UBE2L6 UBE4B MYCBP2 UBR4	8.52e-04	473	65	7	GO:0004842
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR1 UBR2 UBR4	1.08e-07	4	63	3	GO:0071596
GeneOntologyBiologicalProcess	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	9.18e-06	2	63	2	GO:0021816
GeneOntologyBiologicalProcess	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	9.13e-05	5	63	2	GO:0021815
GeneOntologyCellularComponent	phosphorylase kinase complex	PHKA1 PHKA2	1.01e-04	5	67	2	GO:0005964
GeneOntologyCellularComponent	ubiquitin ligase complex	UBR1 UBR2 ZYG11A FBXO10 UBE2L6 UBE4B FBXL20	1.32e-04	352	67	7	GO:0000151
Domain	EYA_fam	EYA4 EYA2 EYA3	1.68e-07	4	66	3	IPR028472
Domain	EYA_dom	EYA4 EYA2 EYA3	1.68e-07	4	66	3	IPR006545
Domain	ZF_UBR	UBR1 UBR2 UBR4	1.46e-06	7	66	3	PS51157
Domain	zf-UBR	UBR1 UBR2 UBR4	1.46e-06	7	66	3	PF02207
Domain	Znf_UBR	UBR1 UBR2 UBR4	1.46e-06	7	66	3	IPR003126
Domain	ZnF_UBR1	UBR1 UBR2 UBR4	1.46e-06	7	66	3	SM00396
Domain	ClpS_core	UBR1 UBR2	1.23e-05	2	66	2	IPR003769
Domain	ClpS	UBR1 UBR2	1.23e-05	2	66	2	PF02617
Domain	Glyco_hydro_15	PHKA1 PHKA2	3.68e-05	3	66	2	PF00723
Domain	Ribosomal_L7/12_C/ClpS-like	UBR1 UBR2	3.68e-05	3	66	2	IPR014719
Domain	Glyco_hydro_15/PHK	PHKA1 PHKA2	3.68e-05	3	66	2	IPR011613
Domain	srGAP2	SRGAP2C SRGAP2	3.68e-05	3	66	2	IPR030252
Domain	-	UBR1 UBR2	3.68e-05	3	66	2	3.30.1390.10
Domain	PHK_A/B_su	PHKA1 PHKA2	3.68e-05	3	66	2	IPR008734
Domain	6hp_glycosidase	PHKA1 PHKA2	3.40e-04	8	66	2	IPR012341
Domain	-	PHKA1 PHKA2	3.40e-04	8	66	2	1.50.10.10
Domain	VWF_A	ITGA11 VWA8 SEC24B VIT	4.16e-04	99	66	4	IPR002035
Domain	6-hairpin_glycosidase-like	PHKA1 PHKA2	9.36e-04	13	66	2	IPR008928
Domain	-	ZYG11A TLR5 LRRCC1 LRRC59 FBXL20 LGR5	9.40e-04	321	66	6	3.80.10.10
Domain	VWA	ITGA11 VWA8 VIT	1.02e-03	56	66	3	PF00092
Domain	L_dom-like	ZYG11A TLR5 LRRCC1 LRRC59 FBXL20 LGR5	1.05e-03	328	66	6	IPR032675
Domain	LRR_1	TLR5 LRRCC1 LRRC59 FBXL20 LGR5	1.06e-03	219	66	5	PF00560
Domain	ARM-type_fold	ZYG11A URB1 MROH2A ANKAR UBR4 BTAF1	1.24e-03	339	66	6	IPR016024
Domain	-	EYA4 ATP13A3 EYA2	1.51e-03	64	66	3	3.40.50.1000
Domain	Leu-rich_rpt	TLR5 LRRCC1 LRRC59 FBXL20 LGR5	2.69e-03	271	66	5	IPR001611
Domain	FCH	SRGAP2C SRGAP2	2.71e-03	22	66	2	PF00611
Domain	FCH	SRGAP2C SRGAP2	2.71e-03	22	66	2	SM00055
Domain	HAD-like_dom	EYA4 ATP13A3 EYA2	2.75e-03	79	66	3	IPR023214
Domain	FCH_dom	SRGAP2C SRGAP2	2.97e-03	23	66	2	IPR001060
Domain	VWFA	ITGA11 VWA8 VIT	3.06e-03	82	66	3	PS50234
Domain	VWA	ITGA11 VWA8 VIT	3.27e-03	84	66	3	SM00327
Domain	-	GDPD4 PLCE1	3.50e-03	25	66	2	3.20.20.190
Domain	F_BAR	SRGAP2C SRGAP2	3.50e-03	25	66	2	IPR031160
Domain	F_BAR	SRGAP2C SRGAP2	3.50e-03	25	66	2	PS51741
Domain	PLC-like_Pdiesterase_TIM-brl	GDPD4 PLCE1	3.50e-03	25	66	2	IPR017946
Domain	LRR	TLR5 LRRCC1 LRRC59 LGR5	5.58e-03	201	66	4	PS51450
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX2 URB1 UBE4B MYCBP2 VWA8 CTC1 GRK6 UBR4 BANP TMEM268 TLN2 ZFYVE26 BTAF1 SRGAP2 ST14 PLXNA1	2.38e-10	1105	67	16	35748872
Pubmed	Mammalian microtubule P-body dynamics are mediated by nesprin-1.	AGO2 SYNE1 DDX6	2.73e-08	4	67	3	24862572
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR1 UBR2 UBR4	2.73e-08	4	67	3	16055722
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR1 UBR2 UBR4	2.73e-08	4	67	3	19008229
Pubmed	EYA4, a novel vertebrate gene related to Drosophila eyes absent.	EYA4 EYA2 EYA3	1.36e-07	6	67	3	9887327
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR1 UBR2 UBR4	5.69e-07	9	67	3	17855541
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR1 UBR2 UBR4	1.48e-06	12	67	3	17360488
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	SMG8 UBE4B DAD1 SRGAP2 CDH3 ST14	1.49e-06	183	67	6	31932471
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 SMG8 DPYSL2 URB1 AGO2 CCT3 UBE4B MYCBP2 TAF1C UBR4 SEC24B ANKRD27 DDX6	1.58e-06	1353	67	13	29467282
Pubmed	X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase.	PHKA1 PHKA2	3.66e-06	2	67	2	8733133
Pubmed	Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.	UBR1 UBR2	3.66e-06	2	67	2	28392261
Pubmed	The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution.	PHKA1 PHKA2	3.66e-06	2	67	2	8226841
Pubmed	Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.	UBR1 UBR2	3.66e-06	2	67	2	20298436
Pubmed	Structural basis of substrate recognition and specificity in the N-end rule pathway.	UBR1 UBR2	3.66e-06	2	67	2	20835242
Pubmed	Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	3.66e-06	2	67	2	16606826
Pubmed	SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.	SRGAP2C SRGAP2	3.66e-06	2	67	2	27373832
Pubmed	Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).	UBR1 UBR2	3.66e-06	2	67	2	16311597
Pubmed	cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis.	PHKA1 PHKA2	3.66e-06	2	67	2	1372435
Pubmed	Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.	UBR1 UBR2	3.66e-06	2	67	2	15548684
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DPYSL2 UBE4B MYCBP2 SYNE1 TAF1C UBR4 DAD1 LRRCC1 TLN2 SRGAP2 EYA3 FLOT1	5.63e-06	1285	67	12	35914814
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PCNX2 STARD9 SYNE1 UBR4 BANP PRICKLE2	6.01e-06	233	67	6	37704626
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	UBR1 UBR2 UBE4B UBR4	6.45e-06	62	67	4	18775313
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2C SRGAP2	1.10e-05	3	67	2	22559944
Pubmed	Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.	EYA2 EYA3	1.10e-05	3	67	2	19351884
Pubmed	A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.	EYA2 EYA3	1.10e-05	3	67	2	9020840
Pubmed	KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.	AGO2 DDX6	1.10e-05	3	67	2	31400113
Pubmed	Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.	UBR1 UBR2	1.10e-05	3	67	2	37057345
Pubmed	Eyes absent represents a class of protein tyrosine phosphatases.	EYA2 EYA3	1.10e-05	3	67	2	14628052
Pubmed	RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	1.10e-05	3	67	2	15317757
Pubmed	Cellular microRNA and P bodies modulate host-HIV-1 interactions.	AGO2 DDX6	1.10e-05	3	67	2	19560422
Pubmed	Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase.	PHKA1 PHKA2	1.10e-05	3	67	2	12876330
Pubmed	Defining the membrane proteome of NK cells.	AGO2 MYCBP2 GRK6 UBR4 DAD1 LRRC59 ATP13A3 FLOT1 ANKRD27 DDX6 NCKAP1L	1.34e-05	1168	67	11	19946888
Pubmed	Dachshund homologues play a conserved role in islet cell development.	EYA4 EYA2 EYA3	1.93e-05	27	67	3	20869363
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2C SRGAP2	2.19e-05	4	67	2	22559943
Pubmed	Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.	UBR1 UBR2	2.19e-05	4	67	2	14585983
Pubmed	The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.	UBR1 UBR2	2.19e-05	4	67	2	32692156
Pubmed	An essential role of N-terminal arginylation in cardiovascular development.	UBR1 UBR2	2.19e-05	4	67	2	12098698
Pubmed	Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.	EYA4 EYA3	2.19e-05	4	67	2	19901965
Pubmed	HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly.	AGO2 DDX6	2.19e-05	4	67	2	22851315
Pubmed	Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.	UBR1 UBR2	2.19e-05	4	67	2	11689692
Pubmed	The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.	UBR1 UBR2	2.19e-05	4	67	2	22670058
Pubmed	Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease.	PHKA1 PHKA2	2.19e-05	4	67	2	1872871
Pubmed	Misexpression of the eyes absent family triggers the apoptotic program.	EYA2 EYA3	2.19e-05	4	67	2	11700312
Pubmed	Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice.	PHKA1 PHKA2	2.19e-05	4	67	2	3472241
Pubmed	Phosphorylase Kinase Deficiency	PHKA1 PHKA2	2.19e-05	4	67	2	21634085
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	UBR1 UBR2 AGO2 UBE2L6 CCT3 SEC24B DAD1 LRRC59 FLOT1 CDH3 DDX6	2.45e-05	1247	67	11	27684187
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	UBR2 AGO2 CCT3 MYCBP2 UBR4 FLOT1	3.19e-05	313	67	6	16196087
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR1 UBR2 MYCBP2 UBR4	3.51e-05	95	67	4	29643511
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	UBR1 UBR2 UBR4	3.58e-05	33	67	3	25582440
Pubmed	Location of phosphorylase kinase (Phk) in the mouse X chromosome.	PHKA1 PHKA2	3.64e-05	5	67	2	4726088
Pubmed	Eyes absent: a gene family found in several metazoan phyla.	EYA2 EYA3	3.64e-05	5	67	2	9195991
Pubmed	Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode.	EYA2 EYA3	3.64e-05	5	67	2	9006082
Pubmed	Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.	EYA2 EYA3	3.64e-05	5	67	2	10490620
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	UBR1 UBR2 AGO2 CCT3 SEC24B LRRC59 DDX6	4.66e-05	494	67	7	26831064
Pubmed	Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.	UBR1 UBR2	5.46e-05	6	67	2	10805755
Pubmed	Adhesion signaling by a novel mitotic substrate of src kinases.	CDH3 ST14	5.46e-05	6	67	2	16007225
Pubmed	Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling.	UBR1 UBR2	5.46e-05	6	67	2	32366662
Pubmed	Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.	AGO2 DDX6	5.46e-05	6	67	2	16756390
Pubmed	The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs.	AGO2 DDX6	5.46e-05	6	67	2	25722370
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	SMG8 AGO2 CCT3 DDX6	5.59e-05	107	67	4	30995489
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	PHKA1 UBR1 UBR2 MYCBP2 UBR4	5.70e-05	212	67	5	33853758
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	DPYSL2 URB1 AGO2 MYCBP2 TAF1C LRRC59 SRGAP2 DDX6	7.50e-05	724	67	8	36232890
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	URB1 MYCBP2 SYNE1 TLN2 ALPK1	7.55e-05	225	67	5	12168954
Pubmed	The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.	UBR1 UBR4	7.63e-05	7	67	2	34893540
Pubmed	A genome-wide scan for common alleles affecting risk for autism.	VWA8 TAF1C	7.63e-05	7	67	2	20663923
Pubmed	Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity.	AGO2 DDX6	7.63e-05	7	67	2	23926332
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBR1 UBR2	7.63e-05	7	67	2	21816346
Pubmed	Role of Rck-Pat1b binding in assembly of processing-bodies.	AGO2 DDX6	7.63e-05	7	67	2	23535175
Pubmed	Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.	AGO2 DDX6	7.63e-05	7	67	2	28683311
Pubmed	Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.	EYA2 EYA3	7.63e-05	7	67	2	9049631
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DPYSL2 URB1 FBXO10 CCT3 HSPBAP1 UBR4 PRICKLE2 GLIPR1L2	8.40e-05	736	67	8	29676528
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DPYSL2 AGO2 CCT3 SYNE1 PRICKLE2 LRRCC1 TLN2 LRRC59 SRGAP2 FLOT1 DDX6	8.50e-05	1431	67	11	37142655
Pubmed	Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.	UBR4 ZFYVE26	1.02e-04	8	67	2	37871017
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PCNX2 UBR2 DPYSL2 USF3 AGO2 UBE4B MYCBP2 ANKAR BANP BTAF1 SRGAP2	1.21e-04	1489	67	11	28611215
Pubmed	Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.	UBR1 CCT3 UBR4	1.26e-04	50	67	3	17550899
Pubmed	A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns.	TLR5 LGR5	1.30e-04	9	67	2	30170812
Pubmed	Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor.	LGR5 CDH3	1.30e-04	9	67	2	29180573
Pubmed	LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.	AGO2 DDX6	1.30e-04	9	67	2	20616046
Pubmed	Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.	AGO2 DDX6	1.30e-04	9	67	2	20014101
Pubmed	Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.	AGO2 DDX6	1.30e-04	9	67	2	16699599
Pubmed	Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.	UBR1 HSPBAP1 LRRC59	1.41e-04	52	67	3	28947420
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	URB1 CCT3 MYCBP2 SYNE1 GRK6 LRRC59 BTAF1 FLOT1 DDX6	1.48e-04	1024	67	9	24711643
Pubmed	The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.	AGO2 DDX6	1.63e-04	10	67	2	23125361
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHKA1 UBR2 EYA4 AGO2 CCT3 MYCBP2 FDFT1 SEC24B EYA2	1.78e-04	1049	67	9	27880917
Pubmed	Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.	UBE2L6 TLR5	1.99e-04	11	67	2	15107846
Pubmed	HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.	AGO2 DDX6	1.99e-04	11	67	2	22915799
Pubmed	A forward genetic screen in mice identifies mutants with abnormal cortical patterning.	MYCBP2 SEC24B	1.99e-04	11	67	2	23968836
Pubmed	Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.	LGR5 CDH3	1.99e-04	11	67	2	23487314
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DPYSL2 UBE4B SYNE1 TLN2 SRGAP2	2.13e-04	281	67	5	28706196
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	DPYSL2 UBE2L6 CCT3 SYNE1 UBR4 SEC24B LRRC59 DDX6	2.14e-04	844	67	8	25963833
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	DPYSL2 UBE2L6 CCT3 LRRC59	2.40e-04	156	67	4	32850835
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 PHKA2 SMG8 EYA4 BTAF1 ANKRD27 PLCE1	2.54e-04	650	67	7	38777146
Pubmed	Stem cell-driven lymphatic remodeling coordinates tissue regeneration.	LGR5 CDH3	3.28e-04	14	67	2	31672914
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	PHKA1 PHKA2	3.28e-04	14	67	2	8432533
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PHKA2 URB1 CCT3 CTC1 SYNE1 TLN2 MAU2 FLOT1 DDX6	3.61e-04	1155	67	9	20360068
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	URB1 CCT3 STARD9 SYNE1 UBR4 TLN2 LRRC59 FLOT1 PLXNA1 DDX6	3.82e-04	1425	67	10	30948266
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	PHKA1 UBR2 PHKA2 EYA4 AFM FDFT1 EYA2 EYA3	4.13e-04	931	67	8	27432908
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	URB1 CCT3 VWA8 FDFT1 UBR4 LRRC59 BTAF1 ATP13A3 FLOT1 DDX6	4.14e-04	1440	67	10	30833792
Pubmed	A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene.	UBR1 STARD9	4.31e-04	16	67	2	7633422
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	URB1 UBE4B FDFT1 UBR4 SEC24B DAD1 LRRC59 BTAF1	4.47e-04	942	67	8	31073040
Interaction	TOP3B interactions	PCNX2 URB1 AGO2 UBE4B MYCBP2 VWA8 CTC1 GRK6 UBR4 SEC24B BANP TMEM268 TLN2 ZFYVE26 BTAF1 SRGAP2 ST14 PLXNA1 DDX6	1.40e-07	1470	66	19	int:TOP3B
Interaction	LYPD6B interactions	UBR1 UBR2 MYCBP2 UBR4	7.92e-06	39	66	4	int:LYPD6B
Cytoband	16q24	TAF1C BANP	2.81e-04	17	67	2	16q24
GeneFamily	EYA transcriptional coactivator and phosphatases	EYA4 EYA2 EYA3	4.32e-08	4	41	3	1044
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR2 UBR4	3.76e-07	7	41	3	785
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2C SRGAP2	1.23e-03	23	41	2	1288
Coexpression	GSE5099_MONOCYTE_VS_ALTERNATIVE_M2_MACROPHAGE_DN	UBR1 AGO2 UBE2L6 GRK6 HEMK1 EYA3	9.27e-06	190	67	6	M6589
Coexpression	GSE17721_POLYIC_VS_GARDIQUIMOD_4H_BMDC_UP	PHKA2 MYCBP2 ZFYVE26 HEMK1 MAU2 CDH3	1.24e-05	200	67	6	M4021
Coexpression	ERWIN_COHEN_BLOOD_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_2DY_UP	SRGAP2C UBE2L6 TMEM268 SRGAP2 SIGLEC1	1.37e-05	119	67	5	M41139
ToppCell	BAL-Mild\|BAL / Compartment, Disease Groups and Clusters	SRGAP2C UBE2L6 TMEM268 SRGAP2 SIGLEC1	1.05e-05	192	67	5	1a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR2 SYNE1 MROH2A UBR4 NCKAP1L	1.05e-05	192	67	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	mild-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DPYSL2 EYA4 SRGAP2 SIGLEC1 ST14	1.27e-05	200	67	5	86f585bf9066b179bbcbc703bf43f15da4a07284
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	UBR2 MYCBP2 BTAF1 SIGLEC1 DDX6	1.27e-05	200	67	5	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	eye disease (implicated_via_orthology)	EYA4 EYA2 EYA3	2.13e-07	6	66	3	DOID:5614 (implicated_via_orthology)
Disease	branchiootorenal syndrome (implicated_via_orthology)	EYA4 EYA2 EYA3	3.72e-07	7	66	3	DOID:14702 (implicated_via_orthology)
Disease	Glycogen phosphorylase kinase deficiency	PHKA1 PHKA2	2.95e-05	4	66	2	cv:C0268147
Disease	glycogen storage disease (is_implicated_in)	PHKA1 PHKA2	1.76e-04	9	66	2	DOID:2747 (is_implicated_in)
Disease	peptidyl-glycine alpha-amidating monooxygenase measurement	MYCBP2 GRK6	2.68e-04	11	66	2	EFO_0801871
Disease	Glycogen storage disease	PHKA1 PHKA2	6.56e-04	17	66	2	cv:C0017919
Disease	cerebral white matter volume change measurement, age at assessment	PRICKLE2 VIT	1.79e-03	28	66	2	EFO_0008007, EFO_0021499
Disease	mean reticulocyte volume	ZYG11A AGO2 FDFT1 TLN2 MAU2 FBXL20 CDH3	2.02e-03	799	66	7	EFO_0010701

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRCVVPQTTVILNND	BANP	111	Q8N9N5
VPTRELALQVSQICI	DDX6	171	P26196
TCPTQTAISQAIIRL	CTC1	1061	Q2NKJ3
PRQSLQQCVAISIQQ	CTCFL	126	Q8NI51
QNKVNCLQTRAIPVT	AFM	196	P43652
ISPQRINICGQLNLV	ATP13A3	481	Q9H7F0
LPSCLVLNSLQQELQ	FBXO10	401	Q9UK96
NCVIVLNVSQRTPTT	CHRNE	321	Q04844
NVQRTTPQTLSNLCL	AGO2	551	Q9UKV8
LVQSVCIQIRGQILQ	ALPK1	191	Q96QP1
CVNVLITTTQLVPAL	EYA3	476	Q99504
ITNVSRPRIVCLNQL	ANKAR	1406	Q7Z5J8
CLRKVVQLITQSPSQ	ANKRD27	286	Q96NW4
SFILAVCLRIQINPQ	DAD1	66	P61803
LCVITVLIVQSQFPN	GLIPR1L2	266	Q4G1C9
CRVTELQQQPLCTSV	LRRC59	266	Q96AG4
VNRAITIANQTNCPL	DPYSL2	236	Q16555
TQPLTSQQLQCIREL	HEMK1	86	Q9Y5R4
RLVQQTILCHQNPVT	PHKA1	16	P46020
CIQQKIVINTSTPLA	KIAA2026	1871	Q5HYC2
QTNVSIPKVNLCLLQ	KIAA1109	1721	Q2LD37
QIISTIRTQNLPNCQ	FDFT1	361	P37268
IRTQNLPNCQLISRS	FDFT1	366	P37268
VLPCIQQIQRISLNT	FLOT1	31	O75955
QVLRNLINSSCDQPL	PCNX2	1811	A6NKB5
LQCVQLTVQPRNVSV	PLXNA1	561	Q9UIW2
IRNALLQQTQPLDSC	NCKAP1L	766	P55160
QCNVITRLRGLQVPV	GDPD4	151	Q6W3E5
VSINCNIRLVPNQEI	ITGA11	1066	Q9UKX5
QTQSPLQLLSQCNIR	PRICKLE2	411	Q7Z3G6
LDCLVNPQVTRIVAQ	HSPBAP1	466	Q96EW2
NCINVLVTTTQLIPA	EYA4	541	O95677
VQQCSIQQSLTVLVP	BTAF1	506	O14981
VPRQLVTNCTQRLEQ	GRK6	121	P43250
RCTLTNIPQTQALLN	SEC24B	561	O95487
LTQLPVITSNTIVRC	SEC24B	591	O95487
PCLKQLQQCIQTIST	MAU2	251	Q9Y6X3
RQITICNQSPVRQVL	CDH3	551	P22223
RLVQQTILCYQNPVT	PHKA2	16	P46019
TVCNQLPNLQVLDLS	LGR5	346	O75473
INTLIRCLQVPEIST	MROH2A	81	A6NES4
NSRPNCVNVLVTTTQ	EYA2	436	O00167
CVNVLVTTTQLIPAL	EYA2	441	O00167
RVLTNQSINCLFTVP	SMG8	316	Q8ND04
VQAVQLCQSALRIPE	SYNE1	5686	Q8NF91
PRVSTAQDVIQQTLC	PLCE1	2156	Q9P212
RIQLQGPVRQVVTCT	TAF1C	261	Q15572
PELVTLNLQTCLQIT	FBXL20	221	Q96IG2
AQALEVIPRTLIQNC	CCT3	441	P49368
PVQSELVQRCQQLQS	SRGAP2C	361	P0DJJ0
CQTIQVPTILNSLQR	MYCBP2	311	O75592
LTRVALEAPTQQCVQ	STARD9	2861	Q9P2P6
TLVQLLTCSPQDQLQ	URB1	1156	O60287
QVLTVLRIDNTCAPI	TMEM268	41	Q5VZI3
TEICLQVNQVTPDQL	UHRF1BP1L	1211	A0JNW5
SQCQALLNRITSVNP	TTLL8	326	A6PVC2
PAVSQLLSNIRSQCI	UBE4B	451	O95155
INQTTCENLLPQQIT	ST14	771	Q9Y5Y6
PVQSELVQRCQQLQS	SRGAP2	361	O75044
TCQVLEALNVLVNRP	UBE2L6	101	O14933
FAVAQRITCPQVLIQ	UBR1	1361	Q8IWV7
VPRIIQNICTEFNSQ	VIT	661	Q6UXI7
LQKQTANVVPVQRTC	USF3	176	Q68DE3
ILENQTVTLVCNTPN	SIGLEC1	336	Q9BZZ2
ESINQLITLCTQQAP	TLN2	1346	Q9Y4G6
CNLTQVPQVLNTTER	TLR5	36	O60602
CVTLLDTNQVVRILP	VWA8	1416	A3KMH1
QTQVPEQRQFVTCIL	UBR2	1096	Q8IWV8
TTVCSLIPRNQLQSV	UBR4	86	Q5T4S7
QNLQCLLLDSTSIPQ	ZYG11A	156	Q6WRX3
QENLSLSVPQVIVSC	ZFYVE26	1216	Q68DK2
CLLSVFQVITINPRN	VN1R2	181	Q8NFZ6
PVNLTEINSSQLQCL	LRRCC1	206	Q9C099