Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	exoribonuclease II activity	DIS3L HELZ2	4.51e-05	3	78	2	GO:0008859
GeneOntologyMolecularFunction	protein-lysine 6-oxidase activity	LOXL2 LOXL4	1.49e-04	5	78	2	GO:0004720
Domain	Requiem/DPF_N_dom	DPF1 DPF2	4.76e-05	3	75	2	IPR025750
Domain	Requiem_N	DPF1 DPF2	4.76e-05	3	75	2	PF14051
Domain	RNase_II/R_CS	DIS3L HELZ2	9.50e-05	4	75	2	IPR022966
Domain	Lysyl_oxidase	LOXL2 LOXL4	1.58e-04	5	75	2	IPR001695
Domain	LYSYL_OXIDASE	LOXL2 LOXL4	1.58e-04	5	75	2	PS00926
Domain	Lysyl_oxidase_CS	LOXL2 LOXL4	1.58e-04	5	75	2	IPR019828
Domain	Lysyl_oxidase	LOXL2 LOXL4	1.58e-04	5	75	2	PF01186
Domain	Sulfatase_CS	ARSH ARSF	1.84e-03	16	75	2	IPR024607
Domain	Gal_mutarotase_SF_dom	MAN2A2 MGAM2	2.08e-03	17	75	2	IPR011013
Domain	SULFATASE_1	ARSH ARSF	2.08e-03	17	75	2	PS00523
Domain	SULFATASE_2	ARSH ARSF	2.08e-03	17	75	2	PS00149
Domain	Sulfatase	ARSH ARSF	2.34e-03	18	75	2	PF00884
Domain	Sulfatase_N	ARSH ARSF	2.34e-03	18	75	2	IPR000917
Domain	Znf_FYVE_PHD	DPF1 RBSN PCLO DPF2	2.90e-03	147	75	4	IPR011011
Domain	SRCR	LOXL2 LOXL4	3.18e-03	21	75	2	PF00530
Domain	SR	LOXL2 LOXL4	4.50e-03	25	75	2	SM00202
Domain	-	LOXL2 LOXL4	4.50e-03	25	75	2	3.10.250.10
Domain	SRCR_1	LOXL2 LOXL4	4.86e-03	26	75	2	PS00420
Domain	SRCR_2	LOXL2 LOXL4	4.86e-03	26	75	2	PS50287
Domain	SRCR-like_dom	LOXL2 LOXL4	4.86e-03	26	75	2	IPR017448
Domain	SRCR	LOXL2 LOXL4	5.23e-03	27	75	2	IPR001190
Domain	Alkaline_phosphatase_core	ARSH ARSF	6.86e-03	31	75	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSH ARSF	6.86e-03	31	75	2	IPR017849
Domain	-	ARSH ARSF	6.86e-03	31	75	2	3.40.720.10
Pubmed	Structure and expression of two members of the d4 gene family in mouse.	DPF1 DPF2	4.97e-06	2	78	2	10602997
Pubmed	Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.	SLC18A1 CETP DNAH17	5.95e-06	16	78	3	24886709
Pubmed	Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.	DPF1 DPF2	1.49e-05	3	78	2	18765789
Pubmed	The d4 gene family in the human genome.	DPF1 DPF2	1.49e-05	3	78	2	8812431
Pubmed	Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities.	LOXL2 LOXL4	1.49e-05	3	78	2	19015874
Pubmed	HELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of the RNB family is expressed from a non-canonical initiation codon.	DIS3L HELZ2	1.49e-05	3	78	2	37602378
Pubmed	The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair.	BRIP1 SPRTN	1.49e-05	3	78	2	36608669
Pubmed	Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions.	SLC18A1 CETP	2.97e-05	4	78	2	20031538
Pubmed	Structural and functional diversity of lysyl oxidase and the LOX-like proteins.	LOXL2 LOXL4	2.97e-05	4	78	2	12686136
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL10A1 LOXL2 FAM20B ADAM10 TNXB	4.78e-05	175	78	5	28071719
Pubmed	Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype.	LOXL2 LOXL4	4.94e-05	5	78	2	21740577
Pubmed	Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.	LOXL2 LOXL4	7.40e-05	6	78	2	17287949
Pubmed	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development.	COL10A1 FAM20B	1.04e-04	7	78	2	20812917
Pubmed	Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.	COL10A1 ADAM10	1.04e-04	7	78	2	31112308
Pubmed	Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.	LOXL2 LOXL4	1.38e-04	8	78	2	19458888
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	DPF1 RBSN PRICKLE3 VPS26B TRIM35 ZFHX3 DPF2 EIF3F	1.92e-04	709	78	8	22988430
Pubmed	TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury.	LOXL2 LOXL4	2.21e-04	10	78	2	23357697
Pubmed	Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-κB RelA/p50 heterodimer.	DPF1 DPF2	2.70e-04	11	78	2	22334708
Pubmed	Development and application of a DNA microarray-based yeast two-hybrid system.	HOXC4 ZNF451 EIF3F SLC4A2	2.93e-04	141	78	4	23275563
Pubmed	Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFβ signaling.	COL10A1 ACVRL1	3.23e-04	12	78	2	31647983
Pubmed	A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.	TUFM MAP3K2	3.81e-04	13	78	2	37408008
Pubmed	Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.	COL10A1 CETP	4.44e-04	14	78	2	21665990
Pubmed	Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer.	PCLO TUFM	5.12e-04	15	78	2	31903119
Pubmed	Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.	LOXL2 LOXL4	5.12e-04	15	78	2	27645581
Pubmed	Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome.	SLC38A2 PCDHA10	5.84e-04	16	78	2	34890862
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DIP2A TRIO DIS3L CLK1 ZNF451 IFIT5 N4BP2L2 EIF3F SIM2 CARS2	5.88e-04	1285	78	10	35914814
Pubmed	MicroRNA-140 plays dual roles in both cartilage development and homeostasis.	COL10A1 ADAM10	6.61e-04	17	78	2	20466812
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DPF1 SETX CLK1 APMAP HELZ2 DPF2 EIF3F TNXB TUFM	7.04e-04	1082	78	9	38697112
Pubmed	Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.	SETX TRIM35	7.42e-04	18	78	2	20064376
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SAMD9L DIS3L DNAH17 HELZ2 TXNDC16 ALPK1	8.54e-04	493	78	6	15368895
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TRIO LOXL2 HELZ2 IFIT5 SPRTN	9.18e-04	332	78	5	37433992
Pubmed	Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.	DIP2A COL10A1	9.19e-04	20	78	2	31291246
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	DIP2A HOXC4 CLK1 ZNF451 LOXL4	1.05e-03	342	78	5	23455924
Pubmed	SWI/SNF chromatin remodeling and cancer.	DPF1 DPF2	1.33e-03	24	78	2	11790558
Pubmed	Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.	DPF1 DPF2	1.33e-03	24	78	2	10078207
Pubmed	The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.	DPF1 DPF2	1.33e-03	24	78	2	12215535
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	LOXL2 ADAM10	1.44e-03	25	78	2	17170699
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MST1R SLC38A2 MAN2A2 BTD LOXL2 FAM20B TXNDC16 ADAM10 SLC4A2	1.46e-03	1201	78	9	35696571
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	EFCAB5 BTD HELZ2 ALPK1 ADAM10 TNXB	1.52e-03	552	78	6	10737800
Pubmed	Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.	DPF1 DPF2	1.56e-03	26	78	2	10778858
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	SLC18A1 CETP	1.56e-03	26	78	2	19060910
Pubmed	An unappreciated role for RNA surveillance.	PDE4A MAN2A2 CLK1	1.59e-03	102	78	3	14759258
Pubmed	REST repression of neuronal genes requires components of the hSWI.SNF complex.	DPF1 DPF2	1.81e-03	28	78	2	12192000
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SLC38A2 RBSN SETX MYH13 ZFHX3 SMCR8 TUFM	1.81e-03	777	78	7	35844135
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	SLC38A2 DIP2A RBSN CATSPERE CLK1 DNAH17 IDE ALPK1 CFAP61	1.84e-03	1242	78	9	30973865
Pubmed	Seven new loci associated with age-related macular degeneration.	COL10A1 CETP	1.94e-03	29	78	2	23455636
Pubmed	Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.	DPF1 DPF2	2.07e-03	30	78	2	31043422
Interaction	LOXL3 interactions	SETX VPS26B APMAP LOXL4	4.13e-06	29	76	4	int:LOXL3
GeneFamily	UPF1 like RNA helicases	SETX HELZ2	4.56e-04	11	53	2	1169
GeneFamily	Sulfatases	ARSH ARSF	1.25e-03	18	53	2	410
Coexpression	GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS	DPF1 SLC38A2 SETX TRIO DIS3L NANS BTD APMAP LOXL2 N4BP2L2 ADAM10 TNFRSF21 SLC4A2 MAP3K2	1.26e-06	1009	77	14	M157
Coexpression	MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN	HOXC4 MOB1A EIF3F TUFM LAX1	3.01e-06	76	77	5	M8315
Coexpression	MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN	HOXC4 MOB1A EIF3F TUFM LAX1	3.42e-05	125	77	5	M19629
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LOXL4 CFAP61 SIM2 ADAM10 PHYHIPL	1.56e-05	181	77	5	6a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SAMD9L TRIO HELZ2 IFIT5 N4BP2L2	1.64e-05	183	77	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL10A1 FAM20B LOXL4 SIM2 TNFRSF21	2.40e-05	198	77	5	3575620db5aeaeb0bdcd7a8ff65c43abd3fa13e4
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SAMD9L SETX HELZ2 ACVRL1 ADAM10	2.52e-05	200	77	5	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial\|10w / Sample Type, Dataset, Time_group, and Cell type.	SAMD9L CATSPERE LOXL2 SIM2 SMCR8	2.52e-05	200	77	5	ff0b2675c68e9fc1fa16b3276431f199f3642eac
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9L SETX CLK1 HELZ2 N4BP2L2	2.52e-05	200	77	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial-Proteoglycan-expressing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	SAMD9L CATSPERE LOXL2 SIM2 SMCR8	2.52e-05	200	77	5	07d2133c85e0a4eb8bef653ee15ecd0f1b2bbd44
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	SAMD9L SETX HELZ2 ACVRL1 ADAM10	2.52e-05	200	77	5	be55cef682ba87250dad97689332c8820b3a7420
Disease	selenium measurement, response to dietary selenium supplementation	TRIO SLC18A1	1.11e-03	20	73	2	EFO_0006331, EFO_0600021
Disease	age-related macular degeneration	COL10A1 CETP TNXB	1.42e-03	89	73	3	EFO_0001365
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	SLC18A1 CETP HELZ2 ADAM10	2.26e-03	222	73	4	EFO_0008317, EFO_0020943
Disease	serum metabolite measurement	SLC38A2 TRIO ASPG CETP DNAH17 TXNDC16 LOXL4 ZFHX3	2.30e-03	945	73	8	EFO_0005653
Disease	1,5 anhydroglucitol measurement	PCDHA10 MGAM2	2.35e-03	29	73	2	EFO_0008009
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	SLC18A1 CETP HELZ2 ADAM10	2.37e-03	225	73	4	EFO_0008317, EFO_0020947

Protein segments in the cluster

Peptide	Gene	Start	Entry
EHEFLFHYCGSYLHA	ARSF	441	P54793
YGEEDFEYHRQSSHH	SLC4A2	66	P04920
SHSDHEFLFHYCGVY	ARSH	416	Q5FYA8
RSHYNIEDFIYFSHH	CFAP61	536	Q8NHU2
TASYLESHHKGHFIY	CETP	241	P11597
HHDFSYVIEKSYLRH	CATSPERE	721	Q5SY80
FHSVIYHEDDINYPH	ADAM10	151	O14672
YHAVVLSYGAEDHRA	FDXR	126	P22570
SYHYTHTHLAEEEGE	DPF1	211	Q92782
ITHYHEHGSLYDFLQ	ACVRL1	276	P37023
TYISEVHEHDGHLYL	APMAP	386	Q9HDC9
HYTGHQDVVVLDHAY	PHYKPL	126	Q8IUZ5
YGHFSYEFSNHRDVV	ALPK1	1161	Q96QP1
YDDEHHSTLVSTRHY	CLK1	331	P49759
FYQLHSHYEEEHSGE	RBSN	26	Q9H1K0
HRHYHSIEVFTHYDL	LOXL4	611	Q96JB6
TEFHGGLHYDIHSLY	MGAM2	521	Q2M2H8
KRHYEQYHGFVVIHG	ASPG	101	Q86U10
THDQVHFYTHLGYQL	NAA80	176	Q93015
ETYYHHIYHTVAIEG	FICD	221	Q9BVA6
HRHYHSMEVFTHYDL	LOXL2	626	Q9Y4K0
TESLDHLAGLSHYYH	PCLO	4136	Q9Y6V0
YRTEKHYAHGSVAHS	OR51J1	151	Q9H342
TLEDHYHADVAYHNS	PDE4A	421	P27815
RRYHVSYHHQEYNDG	MAP3K2	266	Q9Y2U5
HTAHIHATEYAVGIY	LAX1	141	Q8IWV1
AHVEYSTAARHYAHT	TUFM	111	P49411
DVVIRHSFFDHGYNH	HPSE2	416	Q8WWQ2
HYSVYEEARHGTFVG	PCDHA10	31	Q9Y5I2
YFYHGVHKISDQHTL	BRIP1	311	Q9BX63
FYHVGKVYCGRHHAE	PRICKLE3	231	O43900
NVFSTAYHYVHSREH	EFCAB5	1146	A4FU69
TDDHKHQIHYHYGRF	IFIT5	371	Q13325
LEHYSTGSHEDYRVF	DNAH17	3951	Q9UFH2
GHDITEHSVLIHEYY	EIF3F	176	O00303
EFHHYGLALDKYTHF	DIS3L	781	Q8TF46
YYGRTRESGFQHHHQ	HOXC4	36	P09017
DHHEAEYYVAAVYEH	BTD	51	P43251
HAAHYLVLGDKETYH	MAN2A2	601	P49641
HTNYYFDVSHEHLEG	IDE	146	P14735
YTVYGEEALHADHFS	DIP2A	1401	Q14689
IYIREYFHSHVSGGH	HELZ2	581	Q9BYK8
IYHHVTGRYAAYHDL	DERA	301	Q9Y315
GHEFRSHHDYYIIAT	EFNB3	126	Q15768
ETERFGDFHGYIHYL	NXPE1	486	Q8N323
HKEYFDYVREHHGNA	PHYHIPL	191	Q96FC7
VTYEEAHAPHYIAHR	MRPS24	51	Q96EL2
TVYDHAHLGHACSYV	CARS2	81	Q9HA77
FYDAERHCHLYTFHA	TRIM35	441	Q9UPQ4
GYTADHERAYAALQH	TNFRSF21	451	O75509
RSFTHSKEHYHFYEI	PLCD4	506	Q9BRC7
YPFDQFHDSHRYIEH	SAMD9L	166	Q8IVG5
FHDSHRYIEHYTLQP	SAMD9L	171	Q8IVG5
FRVYAHIYHQHFDSV	MOB1A	156	Q9H8S9
YHHVHGCDVFHLRYA	SIM2	266	Q14190
QDLHEYHSGYVHKFR	SETX	1831	Q7Z333
FITEGHERFSDHYYD	ST6GALNAC1	541	Q9NSC7
YGEHKRHLEFSHDQY	NANS	81	Q9NR45
LAAVEDVVGHHGYHY	SLC9A5	481	Q14940
GAFAYVHHLTLYDLE	SMCR8	131	Q8TEV9
IYYFSYHVHVKGTHV	COL10A1	596	Q03692
FDALDDYEHHYHTLH	ZNF511	91	Q8NB15
LYYDRGNHHEFVSLV	VPS26B	76	Q4G0F5
AFLSHYEEHHSIDYV	ZNF451	681	Q9Y4E5
IGSEDVEYAHLYFFH	TXNDC16	201	Q9P2K2
GYLTFYEHVESELLH	SLC38A2	346	Q96QD8
FDYLIGNADRHHYES	FAM20B	281	O75063
FHVDSAAEYYRLHLE	TNXB	4136	P22105
AAEYYRLHLEGYHGT	TNXB	4141	P22105
FHHGEYRTHRTFVQH	ZNF840P	136	A6NDX5
FNDEHHSYDHVIYSL	UBR1	231	Q8IWV7
EAHFSLVHYAGTVDY	MYH13	576	Q9UKX3
YHYAHSHLAEEEGED	DPF2	226	Q92785
VYHTFHDEVDEYRRH	SPRTN	151	Q9H040
YMDEHVRISHFRNHY	TTLL9	91	Q3SXZ7
HLVSYSIEYVHSFHT	MST1R	241	Q04912
HHQGIYEHITLAYSE	TRIO	486	O75962
FGYVRSFVTHAVHDH	ZFHX3	291	Q15911
HLVDLRHTSVYGSVY	SLC18A1	416	P54219
VFSTDDYFHHQDGYR	N4BP2L2	431	Q92802