Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF205 MYNN ZBTB20 ZNF148 PRDM2

3.77e-04320395GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF205 MYNN ZBTB20 ZNF148 PRDM2

4.11e-04326395GO:0001217
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF205 ELF1 MYNN DLX5 ZBTB20 ZNF148 ONECUT1 PRDM2 RBPJ

1.31e-031412399GO:0000981
GeneOntologyMolecularFunctioncysteine-type endopeptidase activator activity involved in apoptotic process

CASP8AP2 NOD1

1.46e-0329392GO:0008656
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF205 ELF1 MYNN DLX5 ZBTB20 ZNF148 ONECUT1 PRDM2 RBPJ

1.65e-031459399GO:0000977
GeneOntologyMolecularFunctionpeptidase activator activity involved in apoptotic process

CASP8AP2 NOD1

1.78e-0332392GO:0016505
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF205 ELF1 MYNN DLX5 ZBTB20 ZNF148 ONECUT1 RBPJ

2.41e-031244398GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF205 ELF1 MYNN DLX5 ZBTB20 ZNF148 ONECUT1 RBPJ

2.76e-031271398GO:0000987
GeneOntologyMolecularFunctionamide transmembrane transporter activity

AQP7B ABCB9

3.05e-0342392GO:0042887
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ELF1 DLX5 ONECUT1 PRDM2 RBPJ

4.46e-03560395GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ELF1 DLX5 ONECUT1 PRDM2 RBPJ

4.67e-03566395GO:0001216
GeneOntologyMolecularFunctionligase activity, forming carbon-nitrogen bonds

NADSYN1 TTLL10

4.81e-0353392GO:0016879
GeneOntologyMolecularFunctioncysteine-type endopeptidase regulator activity involved in apoptotic process

CASP8AP2 NOD1

4.99e-0354392GO:0043028
GeneOntologyMolecularFunctionpeptidase activator activity

CASP8AP2 NOD1

8.26e-0370392GO:0016504
Domain-

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

3.84e-046793873.30.160.60
Domainzf-C2H2

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

4.34e-04693387PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

4.38e-04694387IPR013087
DomainZINC_FINGER_C2H2_2

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

8.45e-04775387PS50157
DomainZINC_FINGER_C2H2_1

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

8.57e-04777387PS00028
DomainZnf_C2H2-like

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

9.88e-04796387IPR015880
DomainZnf_C2H2

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

1.05e-03805387IPR007087
DomainZnF_C2H2

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827 PRDM2

1.08e-03808387SM00355
DomainCollagen

COL26A1 WDR33

1.29e-0285382PF01391
DomainCollagen

COL26A1 WDR33

1.29e-0285382IPR008160
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF462 ZNF205 ELF1 MYNN ZBTB20 ZNF148 ONECUT1 RBPJ

2.67e-0680839820412781
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA6B SNX15 NADSYN1 BCL9 HECTD1 ZNF827 RTTN PCNT BAHCC1

2.87e-06110539935748872
Pubmed

Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia.

ONECUT1 RBPJ

3.67e-06339229388792
Pubmed

Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj.

ONECUT1 RBPJ

3.67e-06339224631193
Pubmed

Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo.

ONECUT1 RBPJ

1.83e-05639221898486
Pubmed

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation.

ONECUT1 RBPJ

2.56e-05739229720662
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 ZNF148 BCL9 PRDM2 BAHCC1

4.42e-0535139538297188
Pubmed

Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons.

DLX5 ZBTB20

5.48e-051039231433982
Pubmed

A census of human transcription factors: function, expression and evolution.

ZNF205 ELF1 DLX5 ZNF148 ONECUT1 PRDM2 RBPJ

5.99e-0590839719274049
Pubmed

RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors.

ONECUT1 RBPJ

8.03e-051239222232429
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF462 CASP8AP2 ZNF148 PRDM2 PCNT

1.01e-0441839534709266
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ZNF462 CASP8AP2 GRIP2 PCNT

1.17e-0422539412168954
Pubmed

LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.

ONECUT1 RBPJ

1.27e-041539226689699
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF462 ELF1 DLX5 TRIM68 ZBTB20 ONECUT1

1.29e-0470939622988430
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYNN MLIP ABCB9 MINDY2 CAMSAP2 WDR33 PCNT BAHCC1

1.67e-04144239835575683
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF462 NADSYN1 MSH5 ZBTB20 COL26A1 HECTD1 ZNF827 PCNT

2.08e-04148939828611215
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

ZNF148 BCL9 WDR33 RBPJ

2.29e-0426839433640491
Pubmed

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode.

DLX5 RBPJ

2.30e-042039218495817
Pubmed

A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.

ZNF462 BCL9

2.54e-042139224025145
Pubmed

Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.

DLX5 RBPJ

2.54e-042139224583262
Pubmed

Jagged1 is essential for osteoblast development during maxillary ossification.

DLX5 RBPJ

2.79e-042239224491691
Pubmed

Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.

GRIP2 RBPJ

3.05e-042339223117660
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

ZNF462 ZNF205 ELF1 HECTD1 RBPJ

3.19e-0453639515840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

ZNF462 ZNF205 ELF1 HECTD1 RBPJ

3.24e-0453839510512203
Pubmed

PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia.

RBPJ PCNT

3.91e-042639229899142
Pubmed

Spatiotemporal structure of cell fate decisions in murine neural crest.

DLX5 ZBTB20

3.91e-042639231171666
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

ONECUT1 RBPJ

3.91e-042639219369401
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CASP8AP2 WDR33 ZMYM6 RBPJ PCNT

4.86e-0458839538580884
Pubmed

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

ONECUT1 RBPJ

4.88e-042939227358050
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CASP8AP2 ZNF205 ZBTB20 ZNF148 WDR33 PRDM2 RBPJ

5.26e-04129439730804502
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF462 ELF1 ZNF148 PRDM2 RBPJ

5.66e-0460839536089195
Pubmed

Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.

RP1 ONECUT1

6.72e-043439226949938
Pubmed

Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.

ONECUT1 RBPJ

7.54e-043639225715395
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

ELF1 ZNF148 WDR33 IMP4

7.73e-0437039422922362
Pubmed

NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo.

DLX5 RBPJ

9.30e-044039226534985
Pubmed

Human transcription factor protein interaction networks.

ZNF462 ELF1 ZNF148 BCL9 WDR33 PRDM2 RBPJ

9.45e-04142939735140242
Pubmed

Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

CASP8AP2 CAMSAP2

9.77e-044139215561718
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

ZNF148 PRDM2 RBPJ BAHCC1

1.01e-0339839435016035
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

ZNF148 BCL9 WDR33

1.09e-0318039335198878
Cytoband15q21.3

MINDY2 ONECUT1

4.11e-043539215q21.3
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF462 ZNF205 MYNN ZBTB20 ZNF148 ZNF827

3.56e-0471825628
GeneFamilyBasic leucine zipper proteins|BTB domain containing

MYNN ZBTB20

1.46e-02134252861
CoexpressionGSE17186_CD21LOW_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN

MYNN NADSYN1 MINDY2 WDR33 RTTN

1.01e-05200385M7193
Diseasealkaline phosphatase measurement

ELF1 RP1 DLX5 ZBTB20 MLIP FHIP2A ONECUT1 ZNF827

3.72e-051015388EFO_0004533
Diseaselifestyle measurement

ZBTB20 FHIP2A ONECUT1 BAHCC1

2.34e-04235384EFO_0010724
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

RP1 MLIP ZNF827 RBPJ

2.50e-04239384EFO_0010934
Diseaseserum albumin measurement

MLIP ZNF148 ABCB9 RBPJ PCNT

9.28e-04592385EFO_0004535
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

MSH5 WDR33

1.61e-0346382DOID:5426 (implicated_via_orthology)
DiseaseIntellectual Disability

ZNF462 FHIP2A ZMYM6 RTTN

2.55e-03447384C3714756
Diseaseprotein-glutamine gamma-glutamyltransferase e measurement

RP1 ZNF827

2.73e-0360382EFO_0020690
Diseaseeye morphology measurement

RP1 DLX5 TTLL10

2.77e-03218383EFO_0007858
Diseasesystemic lupus erythematosus

ELF1 MYNN NADSYN1 MSH5 RALGPS2

3.44e-03799385MONDO_0007915
Diseasebrain measurement, neuroimaging measurement

ZNF462 COL26A1 BAHCC1 RALGPS2

5.34e-03550384EFO_0004346, EFO_0004464
Diseaseage at menarche

ZNF462 MSH5 ZBTB20 PRDM2

6.98e-03594384EFO_0004703
DiseasePsychotic Disorders

BCL9 PCNT

7.53e-03101382C0033975
Diseaseneutrophil count

PLCB2 RP1 BCL9 WDR33 RBPJ PCNT

7.96e-031382386EFO_0004833
Diseasemultiple myeloma

MYNN RP1

9.18e-03112382EFO_0001378
Diseasebrain aneurysm

RP1 PRDM2

9.34e-03113382EFO_0003870

Protein segments in the cluster

PeptideGeneStartEntry
PTPHSAPHALADVMD

BAHCC1

881

Q9P281
SSPEDDMVVAPVTHV

ELF1

126

P32519
LEDQIVHHPETMPSE

ADPRM

131

Q3LIE5
PSMEEISHSVGEHLP

CASP8AP2

1666

Q9UKL3
AMHHPSQESPTLPES

DLX5

26

P56178
SHPMVAIPEHEALDS

MLIP

441

Q5VWP3
HDIPDLGTMSEAKPH

IMP4

171

Q96G21
SVHSAPPLHESMALE

AQP7B

331

A0A075B734
TMEAIGELHGVSHEP

ONECUT1

6

Q9UBC0
EDHHMLLPVTDTQSP

MYNN

571

Q9NPC7
HSEMEIIPSESHPHI

NOD1

6

Q9Y239
HELSLMGPVVHEVSD

PCNT

1751

O95613
VMEHSIVSGADVHEP

HECTD1

1411

Q9ULT8
TIGPDHLDHMTPEQI

BCL9

456

O00512
DEPPHQMDHLSTSLD

FHIP2A

226

Q5W0V3
LHPGDHILSIDGTSM

GRIP2

291

Q9C0E4
TGIHVPSEDIPETMD

CAMSAP2

621

Q08AD1
LEHMIGIHDPLASPE

COL26A1

381

Q96A83
HVEHMQSLPEDPLET

PRDM2

1241

Q13029
GPRHLLDDSVMEPHA

RALGPS2

366

Q86X27
MPHGSDSEPFHEDLL

RP1

1821

P56715
STIHFMPDAPDHESL

MSH5

71

O43196
MESSPESLQPLEHGV

MINDY2

1

Q8NBR6
HSPLDMGHIDLPELE

RTTN

351

Q86VV8
QPTMVHDGSLAPDHL

ABCB9

486

Q9NP78
THPLMDEAVPSLGHA

SEMA6B

401

Q9H3T3
SQSPEHEAHSVVPME

TRIM68

121

Q6AZZ1
PSPTHVAELATMEVE

SNX15

226

Q9NRS6
PDEEPIITHGFTMTT

PLCB2

366

Q00722
MDHTEGSPAEEPPAH

RBPJ

1

Q06330
ETALGLPRDHHMEDP

ZBTB20

271

Q9HC78
PMEVDIQDSHVSISP

ZNF827

676

Q17R98
EMGSEHVSLPLHAEV

ZMYM6

1056

O95789
SLHIKMEPEEPHSEG

ZNF205

46

O95201
TMHVEAGHSAVPEEG

ZNF462

2236

Q96JM2
VEMPHSSVGGSHLED

ZNF148

366

Q9UQR1
HDGPGTSEHREMEAP

WDR33

1236

Q9C0J8
SMEDDPIHHKTPFRG

TTLL10

341

Q6ZVT0
PHSPHIDMGLDGVEI

NADSYN1

181

Q6IA69