Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2D7 CYP2D6 CYP4A11 CYP4A22	1.11e-05	27	104	4	GO:0008391
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	2.69e-05	2	104	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	2.69e-05	2	104	2	GO:0103002
GeneOntologyMolecularFunction	aromatase activity	CYP2D7 CYP2D6 CYP4A11 CYP4A22	3.21e-05	35	104	4	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2D7 CYP2D6 CYP4A11 CYP4A22	1.23e-04	49	104	4	GO:0016712
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.60e-04	4	104	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.60e-04	4	104	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.60e-04	4	104	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.60e-04	4	104	2	GO:0106309
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	3.98e-04	6	104	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	3.98e-04	6	104	2	GO:0062186
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	5.55e-04	7	104	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	5.55e-04	7	104	2	GO:0018685
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	1.18e-03	10	104	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.18e-03	10	104	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.18e-03	10	104	2	GO:0102033
GeneOntologyMolecularFunction	mitochondrial ribosome binding	TACO1 TMEM223	2.02e-03	13	104	2	GO:0097177
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4A11 CYP4A22	2.02e-03	13	104	2	GO:0016713
MousePheno	abnormal locomotor coordination	TACO1 HSPG2 OSTM1 NEUROD4 BACE1 ETV4 TFRC TPP1 AP5Z1 GPR156 PLA2G6 PRKCG GNAS HYDIN BAHCC1	1.80e-05	726	82	15	MP:0003312
Domain	DUF4074	HOXA3 HOXD3	8.83e-05	3	102	2	IPR025281
Domain	DUF4074	HOXA3 HOXD3	8.83e-05	3	102	2	PF13293
Domain	CEBP_ZZ	CPEB3 CPEB4	1.76e-04	4	102	2	IPR032296
Domain	CEBP_ZZ	CPEB3 CPEB4	1.76e-04	4	102	2	PF16366
Domain	RRM_7	CPEB3 CPEB4	1.76e-04	4	102	2	PF16367
Domain	TF_Brachyury	TBXT TBX6	4.37e-04	6	102	2	IPR002070
Domain	Cyt_P450_E_grp-I	CYP2D6 CYP4A11 CYP4A22	1.90e-03	45	102	3	IPR002401
Domain	Cyt_P450_CS	CYP2D6 CYP4A11 CYP4A22	3.04e-03	53	102	3	IPR017972
Domain	CYTOCHROME_P450	CYP2D6 CYP4A11 CYP4A22	3.74e-03	57	102	3	PS00086
Domain	TF_T-box	TBXT TBX6	3.81e-03	17	102	2	IPR001699
Domain	TBOX	TBXT TBX6	3.81e-03	17	102	2	SM00425
Domain	TF_T-box_CS	TBXT TBX6	3.81e-03	17	102	2	IPR018186
Domain	-	TBXT TBX6	3.81e-03	17	102	2	2.60.40.820
Domain	TBOX_3	TBXT TBX6	3.81e-03	17	102	2	PS50252
Domain	T-box	TBXT TBX6	3.81e-03	17	102	2	PF00907
Domain	TBOX_1	TBXT TBX6	3.81e-03	17	102	2	PS01283
Domain	TBOX_2	TBXT TBX6	3.81e-03	17	102	2	PS01264
Domain	-	CYP2D6 CYP4A11 CYP4A22	3.92e-03	58	102	3	1.10.630.10
Domain	p450	CYP2D6 CYP4A11 CYP4A22	3.92e-03	58	102	3	PF00067
Domain	Cyt_P450	CYP2D6 CYP4A11 CYP4A22	4.32e-03	60	102	3	IPR001128
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP2D7 CYP2D6 CYP4A11 CYP4A22	1.92e-06	18	73	4	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP2D7 CYP2D6 CYP4A11 CYP4A22	1.92e-06	18	73	4	MM14841
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP2D6 CYP4A11 CYP4A22	2.83e-05	12	73	3	M27128
Pathway	REACTOME_FATTY_ACIDS	CYP2D6 CYP4A11 CYP4A22	5.80e-05	15	73	3	M27126
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 ABCC3 HSPG2 MFHAS1 FBRSL1 TMEM187 ANKHD1 ARSG MST1R INTS5 ZFP36L2 PLA2G6 AKAP13 MBD5 ARRDC2 BAHCC1	2.14e-07	1105	105	16	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CAMSAP3 PTPN23 SEMA6D TENM3 MBD5 BAHCC1	7.39e-07	103	105	6	10819331
Pubmed	The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.	CYP2D6 CYP4A11 CYP4A22	2.22e-06	9	105	3	7678494
Pubmed	Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.	HSPG2 TJP1 TBXT	5.77e-06	12	105	3	22072575
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	9.03e-06	2	105	2	15611369
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	9.03e-06	2	105	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	9.03e-06	2	105	2	11207030
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	9.03e-06	2	105	2	23641057
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	9.03e-06	2	105	2	28912346
Pubmed	Genetic variants of TBX6 and TBXT identified in patients with congenital scoliosis in Southern China.	TBXT TBX6	9.03e-06	2	105	2	32672867
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	9.03e-06	2	105	2	24413902
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	9.03e-06	2	105	2	8031839
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	9.03e-06	2	105	2	3123997
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	9.03e-06	2	105	2	10860550
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	9.03e-06	2	105	2	11320253
Pubmed	A missense T (Brachyury) mutation contributes to vertebral malformations.	TBXT TBX6	9.03e-06	2	105	2	18466071
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	9.03e-06	2	105	2	12464262
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	9.03e-06	2	105	2	15066132
Pubmed	Maintenance of functional equivalence during paralogous Hox gene evolution.	HOXA3 HOXD3	9.03e-06	2	105	2	10688203
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	9.03e-06	2	105	2	11032406
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	9.03e-06	2	105	2	23825080
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	9.03e-06	2	105	2	16691295
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	9.03e-06	2	105	2	3829886
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	9.03e-06	2	105	2	29277328
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	9.03e-06	2	105	2	21820496
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	9.03e-06	2	105	2	20943934
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	9.03e-06	2	105	2	2766933
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	9.03e-06	2	105	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	9.03e-06	2	105	2	26297049
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	9.03e-06	2	105	2	17112342
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	9.03e-06	2	105	2	15051713
Pubmed	Sequence and expression of the murine Hoxd-3 homeobox gene.	HOXA3 HOXD3	9.03e-06	2	105	2	8710855
Pubmed	Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis.	HOXA3 HOXD3	9.03e-06	2	105	2	7910549
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	9.03e-06	2	105	2	30088983
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	9.03e-06	2	105	2	19208908
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP2D7 CYP2D6 CYP4A11 CYP4A22	9.70e-06	44	105	4	12745259
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2D6 CYP4A11 CYP4A22	1.18e-05	15	105	3	29968852
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2D6 CYP4A11 CYP4A22	1.76e-05	17	105	3	27197076
Pubmed	Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo.	ETV4 TBXT TBX6	2.50e-05	19	105	3	22954964
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	2.70e-05	3	105	2	2354437
Pubmed	Critical role for Tbx6 in mesoderm specification in the mouse embryo.	TBXT TBX6	2.70e-05	3	105	2	12915233
Pubmed	Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.	HOXA3 HOXD3	2.70e-05	3	105	2	7913519
Pubmed	A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice.	GIP GNAS	2.70e-05	3	105	2	17971513
Pubmed	Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain.	TBXT TBX6	2.70e-05	3	105	2	26593875
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	2.70e-05	3	105	2	28270609
Pubmed	CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.	CPEB3 CPEB4	2.70e-05	3	105	2	20937770
Pubmed	CPEB3 Deficiency Elevates TRPV1 Expression in Dorsal Root Ganglia Neurons to Potentiate Thermosensation.	CPEB3 SCN10A	2.70e-05	3	105	2	26915043
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	2.70e-05	3	105	2	37659685
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	2.70e-05	3	105	2	9271096
Pubmed	Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study.	CYP2D6 GNAS	2.70e-05	3	105	2	16315032
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	2.70e-05	3	105	2	2574001
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB3 CPEB4	2.70e-05	3	105	2	12672660
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	2.70e-05	3	105	2	8011168
Pubmed	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	CPEB3 CPEB4	2.70e-05	3	105	2	17024188
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	2.70e-05	3	105	2	1991046
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	2.70e-05	3	105	2	19713718
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	2.70e-05	3	105	2	15313227
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	2.70e-05	3	105	2	1978251
Pubmed	FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis.	ETV4 TBXT TBX6	4.53e-05	23	105	3	21368122
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	THSD7A ATXN7L1 MBD5 BAHCC1 PDZD2	4.83e-05	130	105	5	12421765
Pubmed	Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.	TJP1 TBXT TBX6	5.17e-05	24	105	3	21693517
Pubmed	CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.	CPEB3 CPEB4	5.40e-05	4	105	2	30177570
Pubmed	Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures.	HOXA3 HOXD3	5.40e-05	4	105	2	9441667
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB3 CPEB4	5.40e-05	4	105	2	12871996
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	5.40e-05	4	105	2	8334987
Pubmed	Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.	HSPG2 TENM3	5.40e-05	4	105	2	34174923
Pubmed	Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.	TBXT TBX6	5.40e-05	4	105	2	17668009
Pubmed	The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse.	TBXT FUT4	5.40e-05	4	105	2	9512518
Pubmed	Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation.	TBXT FUT4	5.40e-05	4	105	2	11020711
Pubmed	Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).	HIPK4 HIPK1	5.40e-05	4	105	2	25630557
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	5.40e-05	4	105	2	22159897
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 CYP4A22	5.40e-05	4	105	2	1552159
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	5.40e-05	4	105	2	10049703
Pubmed	The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.	HOXA3 HOXD3	5.40e-05	4	105	2	24127533
Pubmed	Functionally distinct roles for T and Tbx6 during mouse development.	TBXT TBX6	5.40e-05	4	105	2	32855167
Pubmed	Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.	GIP GNAS	5.40e-05	4	105	2	33196462
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	5.40e-05	4	105	2	21161333
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PKD1L2 EEF1G LIPE TENM3 SCN10A PRKCG GNAS	5.72e-05	322	105	7	26514267
Pubmed	Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm.	ETV4 TBXT TBX6	5.86e-05	25	105	3	38345319
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP2D7 CYP2D6 CYP4A11 CYP4A22	6.17e-05	70	105	4	15128046
Pubmed	Lineage tracing of axial progenitors using Nkx1-2CreERT2 mice defines their trunk and tail contributions.	TBXT TBX6	8.97e-05	5	105	2	30201686
Pubmed	Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.	TFRC ZFP36L2	8.97e-05	5	105	2	26952984
Pubmed	Genetic associations with hypertension: meta-analyses of six candidate genetic variants.	CYP4A11 GNAS	8.97e-05	5	105	2	23859711
Pubmed	Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.	HOXA3 HOXD3	8.97e-05	5	105	2	9520319
Pubmed	A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.	CPEB3 CPEB4	8.97e-05	5	105	2	20639532
Pubmed	Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.	CYP4A11 CYP4A22	8.97e-05	5	105	2	8363569
Pubmed	Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.	CPEB3 CPEB4	8.97e-05	5	105	2	21336257
Pubmed	Disruption of the talin gene arrests mouse development at the gastrulation stage.	HSPG2 TBXT	8.97e-05	5	105	2	11084655
Pubmed	Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.	TBXT TBX6	8.97e-05	5	105	2	21555575
Pubmed	Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	8.97e-05	5	105	2	20427718
Pubmed	Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.	LIPE PLA2G6	8.97e-05	5	105	2	16818490
Pubmed	Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.	CYP4A11 CYP4A22	8.97e-05	5	105	2	7601480
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	CYP4A11 CYP4A22 LIPE	9.23e-05	29	105	3	28364022
Pubmed	A census of human transcription factors: function, expression and evolution.	NEUROD4 SOX30 ETV4 HSF5 HOXA3 HOXD3 ZFP36L2 ZFHX2 TBXT PAX4 TBX6	9.67e-05	908	105	11	19274049
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 THSD7A EXPH5 BACE1 PTPN23 ARSG CPEB4 MBD5	1.29e-04	493	105	8	15368895
Pubmed	Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.	CYP4A11 CYP4A22	1.34e-04	6	105	2	28007964
Pubmed	Ectopic expression of T in the paraxial mesoderm disrupts somite maturation in the mouse.	TBXT TBX6	1.34e-04	6	105	2	35276131
Pubmed	New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.	ZNF469 AKAP13	1.34e-04	6	105	2	20719862
Pubmed	Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis.	TJP1 TBXT	1.34e-04	6	105	2	10477764
Pubmed	Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.	CYP4A11 CYP4A22	1.34e-04	6	105	2	11461119
Cytoband	11q12.3	EEF1G INTS5 TMEM223	9.25e-05	38	105	3	11q12.3
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAP1 ATXN7L1 HSF5 TFRC INTS5 CDC42EP2	3.15e-06	170	105	6	833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 MFHAS1 CECR2 ETV4 HOXD3 GNAS	4.96e-06	184	105	6	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MFHAS1 EXPH5 CECR2 SEMA6D HOXD3 CPEB4	5.78e-06	189	105	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MFHAS1 EXPH5 CECR2 SEMA6D HOXD3 CPEB4	5.78e-06	189	105	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RPS6KA1 ITGAX TFRC CATSPER1 SQSTM1 AKAP13	7.99e-06	200	105	6	851c57187db8bc91a393655bca5f13e787a723d4
Drug	tienilic acid	ABCC3 CYP2D7 CYP2D6 CYP4A11 CYP4A22 ENAM	4.59e-06	93	105	6	CID000038409
Drug	p-hydroxymexiletine	CYP2D7 CYP2D6 GNAS	7.85e-06	9	105	3	CID000093286
Drug	paraoxon	CYP2D7 CYP2D6 CYP4A11 CYP4A22 LIPE TPP1 PLA2G6	1.11e-05	164	105	7	CID000009395
Drug	aminopyrine	CYP2D7 CYP2D6 CYP4A11 HIPK1 ACY3 PIPOX CYP4A22	1.46e-05	171	105	7	CID000006009
Drug	5-hydroxypropafenone	CYP2D7 CYP2D6 SCN10A SCNN1D	1.78e-05	34	105	4	CID000107927
Drug	methoxyphenamine	CYP2D7 CYP2D6 EPHA1	2.03e-05	12	105	3	CID000004117
Drug	16 alpha-hydroxytestosterone	CYP2D7 CYP2D6 CYP4A11	2.03e-05	12	105	3	CID000065545
Drug	cupreidine	CYP2D7 CYP2D6	2.11e-05	2	105	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	2.11e-05	2	105	2	CID000074866
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	RPS6KA1 BACE1 TFRC INTS5 ZFP36L2 INTS15 CDC42EP2	2.88e-05	190	105	7	1056_DN
Drug	Metanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A	TANC2 ABCC3 HSPG2 ZNF668 TPP1 SCN10A BAHCC1	3.52e-05	196	105	7	1515_UP
Drug	Tolnaftate [2398-96-1]; Down 200; 13uM; MCF7; HT_HG-U133A	HSPG2 NEUROD4 TENM3 SLC12A9 ZFP36L2 AP5Z1 AKAP13	3.75e-05	198	105	7	4805_DN
Drug	Bergenin monohydrate [477-90-7]; Up 200; 11.6uM; PC3; HT_HG-U133A	MFHAS1 ZFP36L2 SCN10A ZFHX2 MPPE1 EPHA1 BAHCC1	3.75e-05	198	105	7	5870_UP
Drug	Moroxidine hydrochloride [3160-91-6]; Up 200; 19.2uM; MCF7; HT_HG-U133A	TANC2 ATXN7L1 SLC12A9 SCN10A FUT4 MPPE1 BAHCC1	3.87e-05	199	105	7	1527_UP
Drug	Hydroxyzine dihydrochloride [2192-20-3]; Up 200; 9uM; MCF7; HT_HG-U133A	TANC2 ABCC3 ZNF668 ZFP36L2 FUT4 MPPE1 TBX6	4.00e-05	200	105	7	1524_UP
Drug	10-undecynoic acid	CYP2D7 CYP2D6 CYP4A11	6.18e-05	17	105	3	CID000031039
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	6.30e-05	3	105	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	6.30e-05	3	105	2	CID000054736
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	6.30e-05	3	105	2	CID000443037
Drug	phenytoin	CYP2D7 CYP2D6 LIPE CATSPER1 SCN10A SCNN1D OVCA2	7.09e-05	219	105	7	CID000001775
Drug	AC1L1BEQ	CYP2D7 CYP2D6 CYP4A11 CYP4A22 GNAS	7.14e-05	93	105	5	CID000001407
Drug	propafenone	CYP2D7 CYP2D6 CYP4A11 SCN10A SCNN1D	9.16e-05	98	105	5	CID000004932
Drug	lidocaine	CYP2D7 CYP2D6 LIPE SCN10A SCNN1D PRKCG	9.94e-05	160	105	6	CID000003676
Drug	isradipine	CYP2D7 CYP2D6 CATSPER1 SCN10A SCNN1D	1.01e-04	100	105	5	CID000003784
Drug	AC1L1KIN	CYP2D7 CYP2D6 CYP4A11 CYP4A22 PDZD2	1.01e-04	100	105	5	CID000005516
Drug	desethylaprindine	CYP2D7 CYP2D6	1.26e-04	4	105	2	CID000162697
Drug	4,4'-difluorobenzophenone	CYP2D7 CYP2D6	1.26e-04	4	105	2	CID000009582
Drug	Z-10	CYP2D7 CYP2D6	1.26e-04	4	105	2	CID000477529
Drug	1-(1-phenylcyclohexyl)-4-piperidinol	CYP2D7 CYP2D6	1.26e-04	4	105	2	CID000098840
Drug	AC1L2K1Q	CYP2D7 CYP2D6 CYP4A11	1.58e-04	23	105	3	CID000022258
Drug	17-ODYA	CYP2D7 CYP2D6 CYP4A11 PLA2G6	1.71e-04	60	105	4	CID000001449
Drug	senkirkine	ABCC3 CYP2D6 CYP4A11 CYP4A22	1.82e-04	61	105	4	ctd:C009238
Drug	zonisamide	CYP2D7 CYP2D6 SCN10A SCNN1D	1.94e-04	62	105	4	CID000005734
Drug	eptapirone	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID000208928
Drug	L-754,394	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID005481990
Drug	4-hydroxyochratoxin A	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID000114713
Drug	Koe 1801	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID000129632
Drug	2Cmp	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID000023392
Drug	oxosparteine	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID000097492
Drug	threohydrobupropion	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID000000445
Drug	fenproporex	CYP2D7 CYP2D6	2.09e-04	5	105	2	CID000061810
Drug	AC1Q7AUJ	CYP2D7 CYP2D6 CYP4A11 PIPOX CYP4A22	2.11e-04	117	105	5	CID000003303
Drug	8-MOP	CYP2D7 CYP2D6 CYP4A11 PIPOX CYP4A22	2.19e-04	118	105	5	CID000004114
Drug	mexiletine	CYP2D7 CYP2D6 SCN10A SCNN1D	2.47e-04	66	105	4	CID000004178
Drug	procainamide	HSPG2 CYP2D7 CYP2D6 CYP4A11 SCN10A SCNN1D	2.53e-04	190	105	6	CID000004913
Drug	11-deoxy-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	MED20 HIPK1 ZFP36L2 PLA2G6 TBXT MPPE1	2.53e-04	190	105	6	7519_UP
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	BACE1 TFRC INTS5 ZFP36L2 INTS15 CDC42EP2	2.53e-04	190	105	6	1044_DN
Drug	Lobelanidine hydrochloride [6112-86-3]; Down 200; 10.6uM; PC3; HT_HG-U133A	ATXN7L1 ZNF668 SLC12A9 TPP1 AKAP13 EPHA1	2.53e-04	190	105	6	5080_DN
Drug	geldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	HAUS5 BACE1 TFRC ZFP36L2 AP5Z1 CDC42EP2	2.61e-04	191	105	6	1008_DN
Drug	propoxyphene	CYP2D7 CYP2D6 CYP4A11 CYP4A22	2.62e-04	67	105	4	CID000010100
Drug	phenobarbital	ABCC3 CYP2D7 CYP2D6 CYP4A11 ACY3 PIPOX CYP4A22 PRKCG	2.66e-04	360	105	8	CID000004763
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT_HG-U133A	HAUS5 TENM3 ZFP36L2 SQSTM1 INTS15 EPHA1	2.68e-04	192	105	6	4330_DN
Drug	lauric acid	CYP2D7 CYP2D6 CYP4A11 CSMD3 ENAM SCNN1D	2.76e-04	193	105	6	CID000003893
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A	ABCC3 AP5Z1 SCN10A PLA2G6 PAX4 BAHCC1	2.76e-04	193	105	6	4410_DN
Drug	dibucaine	CYP2D7 CYP2D6 SCN10A SCNN1D	2.77e-04	68	105	4	CID000003025
Drug	Leflunomide [75706-12-6]; Up 200; 14.8uM; MCF7; HT_HG-U133A	ATXN7L1 CPEB3 POM121L2 HOXA3 EPHA1 TBX6	2.83e-04	194	105	6	6102_UP
Drug	Iopanoic acid [96-83-3]; Up 200; 7uM; HL60; HT_HG-U133A	HSPG2 ZNF668 ZFP36L2 PLA2G6 MPPE1 EPHA1	2.83e-04	194	105	6	2965_UP
Drug	encainide	CYP2D7 CYP2D6 CYP4A11	2.87e-04	28	105	3	CID000048040
Drug	2-propylpentanoic acid; Down 200; 50uM; HL60; HT_HG-U133A	OSTM1 INTS5 ZFP36L2 SQSTM1 AP5Z1 INTS15	2.91e-04	195	105	6	1163_DN
Drug	Bepridil hydrochloride [74764-40-2]; Down 200; 10uM; HL60; HT_HG-U133A	INTS5 ZFP36L2 AP5Z1 INTS15 GNAS MPPE1	2.91e-04	195	105	6	1274_DN
Drug	Harmaline hydrochloride dihydrate [6027-98-1]; Up 200; 14uM; MCF7; HT_HG-U133A	HSPG2 RPS6KA1 POM121L2 INTS15 FUT4 BAHCC1	2.91e-04	195	105	6	2805_UP
Drug	Chicago sky blue 6B [2610-05-1]; Down 200; 4uM; HL60; HT_HG-U133A	MED20 EXPH5 HAUS5 SLC12A9 TPP1 MPPE1	2.91e-04	195	105	6	1330_DN
Drug	GBR 12909	CYP2D7 CYP2D6 SCN10A SCNN1D	2.93e-04	69	105	4	CID000003455
Drug	BAS 012416453; Up 200; 38uM; MCF7; HT_HG-U133A	HAUS5 IL17RC SLC30A3 ZFP36L2 CDC42EP2 MPPE1	2.99e-04	196	105	6	6880_UP
Drug	Ethotoin [86-35-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A	HSPG2 IL17RC SLC12A9 AP5Z1 PLA2G6 GNAS	2.99e-04	196	105	6	4366_DN
Drug	Cefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A	NEUROD4 TENM3 TPP1 AP5Z1 AKAP13 TBX6	2.99e-04	196	105	6	4718_DN
Drug	5194442; Up 200; 20uM; PC3; HT_HG-U133A	ABCC3 MST1R SEMA6D TENM3 SQSTM1 AP5Z1	2.99e-04	196	105	6	6594_UP
Drug	Pimozide [2062-78-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A	ZNF668 SLC12A9 CDC42EP2 FUT4 MPPE1 EPHA1	2.99e-04	196	105	6	3178_DN
Drug	Chelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; PC3; HT_HG-U133A	IL17RC ZNF668 AP5Z1 SCN10A ZFHX2 TBX6	2.99e-04	196	105	6	5760_DN
Drug	clozapine; Up 200; 10uM; MCF7; HT_HG-U133A	SLC30A3 ZFP36L2 SQSTM1 PLA2G6 BAHCC1 TBX6	3.08e-04	197	105	6	6988_UP
Drug	Procyclidine hydrochloride [1508-76-5]; Down 200; 12.4uM; PC3; HT_HG-U133A	TANC2 ABCC3 HAUS5 ZFP36L2 PLA2G6 EPHA1	3.08e-04	197	105	6	4233_DN
Drug	Ivermectin [70288-86-7]; Up 200; 4.6uM; PC3; HT_HG-U133A	MED20 ABCC3 SOX30 PIPOX CDC42EP2 AKAP13	3.08e-04	197	105	6	2051_UP
Drug	Debrisoquin sulfate [581-88-4]; Down 200; 9uM; MCF7; HT_HG-U133A	MED20 ABCC3 MFHAS1 ZFP36L2 FUT4 BAHCC1	3.08e-04	197	105	6	3207_DN
Drug	aspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A	MED20 MFHAS1 ZFHX2 PLA2G6 FUT4 BAHCC1	3.08e-04	197	105	6	1629_UP
Drug	Acyclovir [59277-89-3]; Up 200; 17.8uM; MCF7; HT_HG-U133A	IL17RC SLC30A3 ZFP36L2 SCN10A PLA2G6 GNAS	3.08e-04	197	105	6	5643_UP
Drug	Tolmetin sodium salt dihydrate [64490-92-2]; Down 200; 12.6uM; HL60; HT_HG-U133A	PIPOX POM121L2 TMEM187 HOXD3 PLA2G6 GNAS	3.08e-04	197	105	6	3009_DN
Drug	U-62066 [87151-85-7]; Down 200; 1uM; PC3; HT_HG-U133A	HSPG2 IL17RC SLC12A9 TPP1 MPPE1 EPHA1	3.08e-04	197	105	6	4553_DN
Drug	8-Methylxanthine	CYP2D7 CYP2D6	3.12e-04	6	105	2	CID000087061
Drug	AC1L45F6	CYP2D7 CYP2D6	3.12e-04	6	105	2	CID000150982
Drug	5-dehydrosparteine	CYP2D7 CYP2D6	3.12e-04	6	105	2	CID000160614
Drug	10-hydroxyochratoxin A	CYP2D7 CYP2D6	3.12e-04	6	105	2	CID000135115
Drug	7-hydroxychlorpromazine	CYP2D7 CYP2D6	3.12e-04	6	105	2	CID000016414
Drug	KRM1674	CYP2D7 CYP2D6	3.12e-04	6	105	2	CID000126235
Drug	nitroguanidine	CYP2D7 CYP2D6	3.12e-04	6	105	2	CID000011174
Drug	Sulfasalazine [599-79-1]; Up 200; 10uM; MCF7; HT_HG-U133A	SLC30A3 SEMA6D TPP1 EPHA1 PDZD2 TBX6	3.16e-04	198	105	6	5446_UP
Drug	Sulfadiazine [68-35-9]; Up 200; 16uM; MCF7; HT_HG-U133A	TANC2 ZNF668 ZFP36L2 PLA2G6 EPHA1 BAHCC1	3.16e-04	198	105	6	1688_UP
Drug	Chenodiol [474-25-9]; Down 200; 10.2uM; PC3; HT_HG-U133A	IL17RC ZFP36L2 SQSTM1 AKAP13 FUT4 MPPE1	3.16e-04	198	105	6	7310_DN
Drug	Nafronyl oxalate [3200-06-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A	HSPG2 ZFP36L2 TPP1 AP5Z1 ZFHX2 GNAS	3.16e-04	198	105	6	2622_UP
Drug	Glutethimide, para-amino [125-84-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A	ABCC3 EXPH5 HAUS5 PLA2G6 FUT4 TBX6	3.16e-04	198	105	6	7421_UP
Drug	dihydralazine	CYP2D7 CYP2D6 ENAM	3.19e-04	29	105	3	CID000010230
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; MCF7; HT_HG-U133A	IL17RC SLC30A3 AP5Z1 SCN10A PLA2G6 EPHA1	3.25e-04	199	105	6	5433_UP
Drug	chlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A_EA	INTS5 ZFP36L2 AP5Z1 INTS15 MPPE1 EPHA1	3.25e-04	199	105	6	997_DN
Drug	Metrizamide [31112-62-6]; Down 200; 5uM; HL60; HT_HG-U133A	EXPH5 TMEM187 ZFP36L2 TPP1 AP5Z1 INTS15	3.25e-04	199	105	6	1318_DN
Drug	DMEs	ABCC3 CYP2D7 CYP2D6 CYP4A11	3.27e-04	71	105	4	CID003038361
Drug	flecainide	CYP2D7 CYP2D6 SCN10A SCNN1D	3.27e-04	71	105	4	CID000003355
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; PC3; HT_HG-U133A	PIPOX POM121L2 GIP SEMA6D TPP1 TBX6	3.33e-04	200	105	6	4091_UP
Drug	Dicloxacillin sodium salt [13412-64-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A	CPEB3 SLC12A9 CDC42EP2 AKAP13 MPPE1 TBX6	3.33e-04	200	105	6	5012_DN
Drug	Midecamycin [35457-80-8]; Up 200; 5uM; MCF7; HT_HG-U133A	HSPG2 PIPOX IL17RC SCN10A GNAS TBX6	3.33e-04	200	105	6	1526_UP
Drug	Pentetic acid [67-43-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A	TANC2 ABCC3 TENM3 AP5Z1 CDC42EP2 GNAS	3.33e-04	200	105	6	5264_DN
Drug	carteolol	CYP2D7 CYP2D6 CYP4A11 CYP4A22	3.45e-04	72	105	4	CID000002583
Disease	solanidine measurement	CYP2D7 CYP2D6	7.21e-05	4	103	2	EFO_0800966
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6 PDZD2	7.93e-05	24	103	3	EFO_0003761, EFO_0005658
Disease	Neuronal Ceroid-Lipofuscinoses	ARSG TPP1	1.79e-04	6	103	2	C0027877
Disease	X-14939 measurement	CYP4A11 CYP4A22	1.79e-04	6	103	2	EFO_0800747
Disease	Acute Confusional Senile Dementia	CYP2D6 BACE1 TPP1 EPHA1	4.09e-04	99	103	4	C0546126
Disease	Alzheimer's Disease, Focal Onset	CYP2D6 BACE1 TPP1 EPHA1	4.09e-04	99	103	4	C0750900
Disease	Alzheimer Disease, Early Onset	CYP2D6 BACE1 TPP1 EPHA1	4.09e-04	99	103	4	C0750901
Disease	Presenile dementia	CYP2D6 BACE1 TPP1 EPHA1	4.09e-04	99	103	4	C0011265
Disease	Alzheimer Disease, Late Onset	CYP2D6 BACE1 TPP1 EPHA1	4.09e-04	99	103	4	C0494463
Disease	Familial Alzheimer Disease (FAD)	CYP2D6 BACE1 TPP1 EPHA1	4.25e-04	100	103	4	C0276496
Disease	Alzheimer's Disease	CYP2D6 BACE1 TPP1 EPHA1	4.41e-04	101	103	4	C0002395
Disease	lymphocyte count	ADAP1 EXPH5 RPS6KA1 TMEM187 ZNF831 HOXA3 MST1R ZNF469 ZFP36L2 SQSTM1 CD300LG PLA2G6 ARRDC2 RNF212B	5.66e-04	1464	103	14	EFO_0004587
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	6.50e-04	11	103	2	DOID:0110861 (biomarker_via_orthology)
Disease	kynurenic acid measurement	THSD7A SEMA6D	9.18e-04	13	103	2	EFO_0010506
Disease	hyperglycemia (is_marker_for)	HSPG2 GIP	9.18e-04	13	103	2	DOID:4195 (is_marker_for)
Disease	mean arterial pressure	PIPOX ZNF831 HOXA3 SLC12A9 CPEB4 GNAS BAHCC1	1.86e-03	499	103	7	EFO_0006340
Disease	prion disease	MFHAS1 CPEB4	1.99e-03	19	103	2	EFO_0004720
Disease	Paroxysmal atrial fibrillation	HSPG2 FBRSL1 SCN10A MBD5	2.21e-03	156	103	4	C0235480
Disease	familial atrial fibrillation	HSPG2 FBRSL1 SCN10A MBD5	2.21e-03	156	103	4	C3468561
Disease	Persistent atrial fibrillation	HSPG2 FBRSL1 SCN10A MBD5	2.21e-03	156	103	4	C2585653
Disease	Atrial Fibrillation	HSPG2 FBRSL1 SCN10A MBD5	2.43e-03	160	103	4	C0004238
Disease	total iron binding capacity	THSD7A POM121L2 TFRC	2.60e-03	78	103	3	EFO_0006334
Disease	Allodynia	PROKR1 SCN10A PRKCG	3.21e-03	84	103	3	C0458247
Disease	Mechanical Allodynia	PROKR1 SCN10A PRKCG	3.21e-03	84	103	3	C2936719
Disease	Hyperalgesia, Secondary	PROKR1 SCN10A PRKCG	3.21e-03	84	103	3	C0751212
Disease	Hyperalgesia, Primary	PROKR1 SCN10A PRKCG	3.21e-03	84	103	3	C0751211
Disease	Hyperalgesia, Thermal	PROKR1 SCN10A PRKCG	3.21e-03	84	103	3	C0751214
Disease	Tactile Allodynia	PROKR1 SCN10A PRKCG	3.21e-03	84	103	3	C0751213
Disease	Hyperalgesia	PROKR1 SCN10A PRKCG	3.21e-03	84	103	3	C0020429
Disease	Colorectal Carcinoma	ABCC3 OTOP2 LRRC4 CSMD3 TFRC ZFP36L2 GNAS EPHA1	3.23e-03	702	103	8	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGTTAHPRGFPELSH	GNAS	171	P84996
HFSPGARGLTTPAVH	EPHA1	391	P21709
PTHVPASLGAFAGHS	FBRSL1	311	Q9HCM7
SSNFAVGAAPHPFLH	BACE1	96	P56817
PVHSVATPIFGNGFR	BAHCC1	2171	Q9P281
FPRTEAGHLAGTVHP	ACY3	231	Q96HD9
FGLAPSQGAVPSHRS	CATSPER1	96	Q8NEC5
PHPTNFRTRLTGFHL	CSMD3	126	Q7Z407
HPGLDNSRPFHSTFH	AKAP13	1696	Q12802
FDPFRFAPGSAQHSH	CYP4A11	431	Q02928
FAPGSAQHSHAFLPF	CYP4A11	436	Q02928
HASGTSFHLPQPSFR	BRPF3	106	Q9ULD4
HSQPTFFPGGLRFSV	B3GALT5	261	Q9Y2C3
FGRSQPGHRVLFHPN	ARSG	396	Q96EG1
GHFSALPSLPVGSHA	GIP	26	P09681
YTVLHGFPPSTQGHH	ADAP1	306	O75689
QGLPHSGGFFSTPRA	AP5Z1	191	O43299
SPVFTFRHPLLSSGG	CAMSAP3	351	Q9P1Y5
RGFQSNHPHSGGFPR	CECR2	1181	Q9BXF3
PLHPFGSRSSSVGSH	ARRDC2	306	Q8TBH0
FSTHHPRPLAFCSFG	ATXN7L1	456	Q9ULK2
NFLRSSGTSQPHPGH	ETV4	161	P43268
FSFRPSPNGHSGHTR	RNF212B	236	A8MTL3
RHLISTHFAPGDFQG	HSPG2	1341	P98160
FHGVLGPSISPSHSQ	ITGAX	556	P20702
HHFSSGIPAGFPAPR	PTPN23	936	Q9H3S7
THPGHTFISGVTFPF	INTS15	431	Q96N11
SFHGLVHGRAPAPVF	ABCC3	91	O15438
HTPFSQGGHFPTIFS	FAM166C	61	A6NJV1
SNSGPALFGLTHLPH	HOXA3	376	O43365
HFPTTVGSFLHRVGA	MFHAS1	511	Q9Y4C4
SHQHGPPRGATSFLQ	HIPK4	596	Q8NE63
PPRGATSFLQHVTGH	HIPK4	601	Q8NE63
PYTFQHGSPLHSTGH	HIPK1	1081	Q86Z02
PLHSGTAPFHSRASG	FUT4	76	P22083
HHGGRVPELSVPSFS	MPPE1	311	Q53F39
PAQFSSHFGREGHPP	PDZD2	2226	O15018
NHPFQGSHRQTPDFG	PCED1A	291	Q9H1Q7
SGNHFPEIRPGSFHG	LRRC4	226	Q9HBW1
LPATGHFTARSLHFP	EXPH5	331	Q8NEV8
GGRPHFLTQLHSTFQ	PRKCG	411	P05129
GPVFNLGHLSHPSSA	HOXD3	371	P31249
HQLHPASPRGSSFIA	HAUS5	481	O94927
GALPFGSSPHRVFHD	OSTM1	31	Q86WC4
PHRQHRLFTAPTFTG	SMPD4	536	Q9NXE4
RLVGPRGFSQPHSHA	PKD1L2	1766	Q7Z442
HPGTGHRNRTIFSPS	PAX4	166	O43316
GRFLASTPGHSHTPT	OTOP2	266	Q7RTS6
IGPTFHFNVPALHFG	HYDIN	561	Q4G0P3
SPPLGDFRHTIHIGS	CDC42EP2	31	O14613
HHVNPVFGGTFSPQI	CPEB3	141	Q8NE35
GQPRPSHHGVFAFLV	CYP2D6	471	P10635
FDPSRFAPGSAQHSH	CYP4A22	431	Q5TCH4
FAPGSAQHSHAFLPF	CYP4A22	436	Q5TCH4
GFHGAPNSSPIHLNR	MBD5	256	Q9P267
HFPGSAPSSVGHRAN	GPR156	611	Q8NFN8
LFQNFPHHVSPGFGG	CPEB4	206	Q17RY0
GAQVRVLSAPPHFHF	EEF1G	26	P26641
VLSAPPHFHFGQTNR	EEF1G	31	P26641
PHFHFGQTNRTPEFL	EEF1G	36	P26641
HLPHPSHGSRGSVFY	ENAM	586	Q9NRM1
FLGHHSFSVRPGTEA	SCNN1D	501	P51172
PGAHGPHDAFRASLS	IL17RC	671	Q8NAC3
TTGHGFPHFSEAPAR	PRIMPOL	211	Q96LW4
FPEGFHPRRSSQGAT	LIPE	941	Q05469
FTFFAHRFGGHTIPP	OR52N5	266	Q8NH56
IHSHRPLGPGEFESF	PIP4K2C	336	Q8TBX8
GSHTPGAPAVFGNRH	MED20	166	Q9H944
PRQVQYTHFGSHSPG	FREM3	121	P0C091
EPHGPVAVGQFHRSF	HSF5	181	Q4G112
NGFPLRSTHPFGHSV	MEIOC	686	A2RUB1
FQGGLRSPRVHHFSP	TOR2A	111	Q8N2E6
HRTRHVVAPPQFGGS	THSD7A	216	Q9UPZ6
PHRLHPSFDFGQLQT	RNF165	136	Q6ZSG1
PGRTLHFTAAVPAGH	TACO1	46	Q9BSH4
AVAGFSSRHPLSPGF	PRAM1	396	Q96QH2
SPPHTSPAHQGGSYR	TANC2	1501	Q9HCD6
GSRTPHYGSQTPLHD	SUPT5H	796	O00267
HYGSQTPLHDGSRTP	SUPT5H	801	O00267
GSAAPHHPFSLERAQ	PLA2G6	426	O60733
GVHRFFASLRLHGPP	INTS5	651	Q6P9B9
THSGGHFIPAAAPQR	OVCA2	201	Q8WZ82
PFRHVFWGSGSHTLP	TFRC	696	P02786
DFTPATGFIFPPHHH	POM121L2	676	Q96KW2
GRSHGPVRFHSVPAF	L3HYPDH	151	Q96EM0
ATLFGTPPRFSFHHP	SOX30	601	O94993
RGHTKLAFPSPFGHL	SQSTM1	161	Q13501
VGTPSFNRQHFSPHP	ANKHD1	2321	Q8IWZ3
GHERTSQYTGTSPHP	CD300LG	191	Q6UXG3
QETTPPDRSHHSGFG	CLUHP3	36	Q96NS8
HFSFSVAAGQPRPSH	CYP2D7	481	A0A087X1C5
SVLNPHGAHATSFPF	PROKR1	21	Q8TCW9
FQGGLRSPRVHHFSP	TOR2A	111	Q5JU69
TTHAPFGLGAHFTVP	TMEM223	136	A0PJW6
FPNAPRAARHAATHG	ZNF668	31	Q96K58
GFHHVGAPARKFPTS	ZFHX2	666	Q9C0A1
HGSVFHFRSPGRDIS	SCN10A	501	Q9Y5Y9
SLPPRFGHFTGFNSS	SLC12A9	231	Q9BXP2
VTFGFHLHNAIPGFP	TENM3	2411	Q9P273
FHGAPSHLPTRSPSF	TBX6	356	O95947
HPQFGGALSLPSTHS	TBXT	261	O15178
FVLHQAGPPHSHGSR	SLC30A3	196	Q99726
LVSGAPFSPRGANFH	ZNF469	1651	Q96JG9
QHTVTLHRAPGFGFG	TJP1	21	Q07157
HFNTHPRFHPSGGKT	TMEM187	246	Q14656
LEQFFLPHSRGSSHG	PIPOX	36	Q9P0Z9
RPSSFGSKGTFPHHD	ZNF831	1471	Q5JPB2
HGHGASRKETPQFFP	SEMA6D	796	Q8NFY4
HSLSFSGFPSGHHQP	ZFP36L2	256	P47974
LTEFHPHSGPLRGST	MST1R	571	Q04912
RRHTEHGAAFPPGSS	ZNF584	131	Q8IVC4
HVDFVGGLHRFPPTS	TPP1	166	O14773
IPPSAGAHQLFRGFS	RPS6KA1	366	Q15418
GHVHSTPFQAGTPRY	NEUROD4	291	Q9HD90