Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tRNA-4-demethylwyosine synthase activity	TYW1B TYW1	1.71e-05	2	83	2	GO:0102521
GeneOntologyMolecularFunction	oxo-acid-lyase activity	TYW1B TYW1	3.54e-04	7	83	2	GO:0016833
GeneOntologyMolecularFunction	tRNA pseudouridine synthase activity	RPUSD4 PUS1	4.70e-04	8	83	2	GO:0106029
GeneOntologyMolecularFunction	cadherin binding	GAPVD1 SLK EIF3E CDH23 PLEC SNX9 PHLDB2	5.26e-04	339	83	7	GO:0045296
GeneOntologyBiologicalProcess	mitochondrial tRNA pseudouridine synthesis	RPUSD4 PUS1	1.56e-05	2	82	2	GO:0070902
HumanPheno	Aplasia of the bladder	FREM2 CC2D2A PLEC	2.69e-06	5	34	3	HP:0010477
Domain	tRNA_wybutosine-synth	TYW1B TYW1	1.86e-05	2	81	2	IPR013917
Domain	Wyosine_form	TYW1B TYW1	1.86e-05	2	81	2	PF08608
Domain	Cul7	CUL9 HERC2	5.56e-05	3	81	2	PF11515
Domain	CPH_domain	CUL9 HERC2	5.56e-05	3	81	2	IPR021097
Domain	APC_su10/DOC_dom	CUL9 HERC2	3.85e-04	7	81	2	IPR004939
Domain	DOC	CUL9 HERC2	3.85e-04	7	81	2	PS51284
Domain	SWIM	ZSWIM5 ZSWIM4	3.85e-04	7	81	2	PF04434
Domain	APC10	CUL9 HERC2	3.85e-04	7	81	2	SM01337
Domain	ANAPC10	CUL9 HERC2	3.85e-04	7	81	2	PF03256
Domain	FLAVODOXIN_LIKE	TYW1B TYW1	5.11e-04	8	81	2	PS50902
Domain	Flavodoxin/NO_synth	TYW1B TYW1	5.11e-04	8	81	2	IPR008254
Domain	Flavdoxin-like	TYW1B TYW1	5.11e-04	8	81	2	IPR001094
Domain	Flavodoxin_1	TYW1B TYW1	5.11e-04	8	81	2	PF00258
Domain	rSAM	TYW1B TYW1	6.56e-04	9	81	2	IPR007197
Domain	Radical_SAM	TYW1B TYW1	6.56e-04	9	81	2	PF04055
Domain	Znf_SWIM	ZSWIM5 ZSWIM4	6.56e-04	9	81	2	IPR007527
Domain	ZF_SWIM	ZSWIM5 ZSWIM4	6.56e-04	9	81	2	PS50966
Domain	Flavoprotein-like_dom	TYW1B TYW1	8.17e-04	10	81	2	IPR029039
Domain	-	TYW1B TYW1	8.17e-04	10	81	2	3.40.50.360
Domain	PsdUridine_synth_cat_dom	RPUSD4 PUS1	1.40e-03	13	81	2	IPR020103
Domain	Rib_L2_dom2	CUL9 HERC2	2.72e-03	18	81	2	IPR014722
Domain	-	CUL9 HERC2	2.72e-03	18	81	2	2.30.30.30
Domain	Apc4_WD40_dom	NWD1 WDR36	3.36e-03	20	81	2	IPR024977
Domain	ANAPC4_WD40	NWD1 WDR36	3.36e-03	20	81	2	PF12894
Domain	CRAL_TRIO	BNIP2 TRIO	3.70e-03	21	81	2	PF00650
Domain	-	CUL9 HERC2 BTBD9	3.93e-03	73	81	3	2.60.120.260
Domain	-	BNIP2 TRIO	4.43e-03	23	81	2	3.40.525.10
Domain	SEC14	BNIP2 TRIO	5.22e-03	25	81	2	SM00516
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 IQSEC3 SLK TRIO KDM5A YLPM1 TNRC6B MPDZ SYNPO MTCL1 HERC2 BTBD9 PHLDB2 SH3BP5	7.45e-08	963	84	14	28671696
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SLK WDR36 VWA8 POLA1 KLHL15 YLPM1 EIF3E MPDZ ABCC12 MTCL1 PLEC HERC2 BTBD9 TADA3	1.25e-07	1005	84	14	19615732
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CSDE1 GAPVD1 WDR36 POLA1 DHX37 YLPM1 EIF3E CUL9 PLEC HERC2 SNX9	5.05e-07	653	84	11	22586326
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	RPUSD4 TRIO DHX37 MPDZ CUL9 UBAC2 HERC2	8.62e-07	212	84	7	33853758
Pubmed	Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.	TYW1B TYW1	5.76e-06	2	84	2	16162496
Pubmed	Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.	CDH23 SESN2	5.76e-06	2	84	2	28818524
Pubmed	Genetic association of PRKCD and CARD9 polymorphisms with Vogt-Koyanagi-Harada disease in the Chinese Han population.	CARD9 PRKCD	5.76e-06	2	84	2	36782298
Pubmed	Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease.	PLEC GFAP	5.76e-06	2	84	2	16507904
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	KIAA1671 CSDE1 GAPVD1 TRIO DHX37 PUS1 TNRC6B PLEC HERC2 CCDC77 SNX9	6.60e-06	853	84	11	28718761
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KIAA1671 CSDE1 GAPVD1 SLK BRD4 YLPM1 TNRC6B MPDZ SNX9	7.34e-06	549	84	9	38280479
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CSDE1 SLK KDM5A POLA1 DHX37 YLPM1 TNRC6B PLEC SNX9 TADA3	9.92e-06	724	84	10	36232890
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	KIAA1671 GAPVD1 TRIO TNRC6B MPDZ MTCL1	1.21e-05	209	84	6	36779422
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	KIAA1671 TANC2 GAPVD1 TNRC6B MPDZ MTCL1 CCDC77 PHLDB2	1.28e-05	446	84	8	24255178
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ELOA TRIO VWA8 ARPC1A YLPM1 TNRC6B MTCL1 HERC2 BTBD9 COLGALT1 TADA3	1.36e-05	922	84	11	27609421
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	WDR36 VWA8 POLA1 DHX37 BRD4 EIF3E TNRC6B HERC2 COLGALT1 PHLDB2	1.41e-05	754	84	10	33060197
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SLK RBM12 VWA8 DHX37 CUL9	1.65e-05	130	84	5	12421765
Pubmed	Plectin-RACK1 (receptor for activated C kinase 1) scaffolding: a novel mechanism to regulate protein kinase C activity.	PRKCD PLEC	1.73e-05	3	84	2	14966116
Pubmed	TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) δ/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice.	CARD9 PRKCD	1.73e-05	3	84	2	33947214
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	IQSEC3 SLK TRIO MPDZ SYNPO BTBD9	3.38e-05	251	84	6	27507650
Pubmed	Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome.	OLIG2 GFAP	3.45e-05	4	84	2	17823967
Pubmed	Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.	SYNPO2 SYNPO	3.45e-05	4	84	2	11673475
Pubmed	Developmental expression of IL-33 in the mouse brain.	OLIG2 GFAP	3.45e-05	4	84	2	24076135
Pubmed	Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis.	TYW1B TYW1	3.45e-05	4	84	2	17150819
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 TANC2 GAPVD1 TRIO KDM5A BRD4 MPDZ MTCL1 PLEC PHLDB2	4.34e-05	861	84	10	36931259
Pubmed	Megalin deficiency induces critical changes in mouse spinal cord development.	OLIG2 GFAP	5.74e-05	5	84	2	18388738
Pubmed	Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.	OLIG2 GFAP	5.74e-05	5	84	2	28115362
Pubmed	The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules.	RPUSD4 PUS1	5.74e-05	5	84	2	28082677
Pubmed	Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.	RPUSD4 PUS1	5.74e-05	5	84	2	35051350
Pubmed	Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.	OLIG2 GFAP	5.74e-05	5	84	2	11091082
Pubmed	Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.	OLIG2 GFAP	5.74e-05	5	84	2	32449185
Pubmed	HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.	EIF3E HERC2 TOP3A	5.82e-05	31	84	3	30279242
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CSDE1 IQSEC3 SLK ZSWIM5 TNRC6B CUL9 MTCL1	5.96e-05	407	84	7	12693553
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CSDE1 TRIO KDM5A YLPM1 CUL9 BEX4 SYNPO PLEC HERC2 OLIG2 GFAP SH3BP5	5.96e-05	1285	84	12	35914814
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	KIAA1671 GAPVD1 SLK EIF3E MARVELD2 PLEC SNX9 PHLDB2	6.82e-05	565	84	8	25468996
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ELOA GAPVD1 TRIO YLPM1 EIF3E TNRC6B MPDZ TYW1 CDT1	7.03e-05	733	84	9	34672954
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	CSDE1 SLC25A18 MTCL1 PLEC HERC2	8.21e-05	182	84	5	31067453
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	KIAA1671 CSDE1 ELOA GAPVD1 SLK RBM12 WDR36 YLPM1 TNRC6B SNX9	8.53e-05	934	84	10	33916271
Pubmed	Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.	CARD9 PRKCD	8.59e-05	6	84	2	27926862
Pubmed	STAT3 but not STAT1 is required for astrocyte differentiation.	OLIG2 GFAP	8.59e-05	6	84	2	24466267
Pubmed	Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system.	NWD1 GFAP	8.59e-05	6	84	2	30004576
Pubmed	Expression of the Ste20-like kinase SLK during embryonic development and in the murine adult central nervous system.	SLK GFAP	8.59e-05	6	84	2	12480135
Pubmed	Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription.	ELOA BRD4	8.59e-05	6	84	2	17690245
Pubmed	The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord.	OLIG2 GFAP	8.59e-05	6	84	2	17178400
Pubmed	Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes.	PLEC GFAP	8.59e-05	6	84	2	17515952
Pubmed	Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype.	CDH23 GFAP	8.59e-05	6	84	2	18001149
Pubmed	Regional- and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium.	OLIG2 GFAP	8.59e-05	6	84	2	18582453
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	KIAA1671 FREM2 YLPM1 TNRC6B PLEC CCDC77	9.39e-05	302	84	6	30561431
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ELOA GAPVD1 KDM5A BRD4 YLPM1 PRKCD CDT1 PLEC PHLDB2	1.06e-04	774	84	9	15302935
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CSDE1 ELOA WDR36 VWA8 KDM5A DHX37 YLPM1 TNRC6B CCDC106 PLEC HERC2 CCDC77	1.10e-04	1371	84	12	36244648
Pubmed	Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.	OLIG2 GFAP	1.20e-04	7	84	2	32135084
Pubmed	Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.	PLEC PHLDB2	1.20e-04	7	84	2	23525008
Pubmed	The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition.	OLIG2 GFAP	1.20e-04	7	84	2	32123192
Pubmed	SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.	BRD4 CDT1	1.20e-04	7	84	2	34599168
Pubmed	Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.	OLIG2 GFAP	1.20e-04	7	84	2	21849552
Pubmed	Syk kinase-coupled C-type lectin receptors engage protein kinase C-δ to elicit Card9 adaptor-mediated innate immunity.	CARD9 PRKCD	1.20e-04	7	84	2	22265677
Pubmed	Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.	OLIG2 GFAP	1.20e-04	7	84	2	11507077
Pubmed	HOPX Defines Heterogeneity of Postnatal Subventricular Zone Neural Stem Cells.	OLIG2 GFAP	1.20e-04	7	84	2	30174314
Pubmed	The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.	CDT1 OLIG2 GFAP	1.26e-04	40	84	3	26657772
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GAPVD1 SLK WDR36 TRIO POLA1 DHX37 ARPC1A EIF3E PUS1 CC2D2A PRKCD COLGALT1	1.58e-04	1425	84	12	30948266
Pubmed	Fgfr3 regulates development of the caudal telencephalon.	OLIG2 GFAP	1.60e-04	8	84	2	21491541
Pubmed	Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy.	OLIG2 GFAP	1.60e-04	8	84	2	15102707
Pubmed	Expression of olig2 in retinal progenitor cells.	OLIG2 GFAP	1.60e-04	8	84	2	16514356
Pubmed	Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.	OLIG2 GFAP	1.60e-04	8	84	2	22529900
Pubmed	Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence.	OLIG2 GFAP	1.60e-04	8	84	2	39196941
Pubmed	Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.	GAPVD1 GFAP	1.60e-04	8	84	2	19725050
Pubmed	Expression Analyses of C-Terminal-Binding Protein 1 (CtBP1) during Mouse Brain Development.	OLIG2 GFAP	1.60e-04	8	84	2	37906993
Pubmed	Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.	SYNPO2 SYNPO	1.60e-04	8	84	2	17923693
Pubmed	Prox1 expression patterns in the developing and adult murine brain.	OLIG2 GFAP	1.60e-04	8	84	2	17117441
Pubmed	Mek1Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome.	OLIG2 GFAP	1.60e-04	8	84	2	29590634
Pubmed	Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development.	OLIG2 GFAP	1.60e-04	8	84	2	16574431
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EFCAB5 ELOA SLC25A18 KDM5A ZSWIM5 YLPM1 CC2D2A CFAP74 SYNPO PLEC CCDC77 SNX9	1.76e-04	1442	84	12	35575683
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CSDE1 FREM2 SLK DHX37 MPDZ COLGALT1 EDEM1 TOP3A	1.79e-04	650	84	8	38777146
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	KIAA1671 WDR36 ARPC1A YLPM1 EIF3E PLEC COLGALT1 PHLDB2	1.98e-04	660	84	8	32780723
Pubmed	Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice.	DDC GFAP	2.05e-04	9	84	2	23264561
Pubmed	A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.	SLK TNRC6B	2.05e-04	9	84	2	21460842
Pubmed	Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor.	OLIG2 GFAP	2.05e-04	9	84	2	11526078
Pubmed	Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm.	OLIG2 GFAP	2.05e-04	9	84	2	31731293
Pubmed	Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.	OLIG2 GFAP	2.05e-04	9	84	2	25754822
Pubmed	Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development.	OLIG2 GFAP	2.05e-04	9	84	2	29203794
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	KLHL15 CUL9 BTBD9	2.17e-04	48	84	3	33504946
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	KIAA1671 ELOA TRIO KLHL15 YLPM1 PUS1 MARVELD2 HERC2 COLGALT1 CCDC77	2.19e-04	1049	84	10	27880917
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	RAD51C GAPVD1 TRIO COLGALT1 SNX9	2.44e-04	230	84	5	35449600
Pubmed	Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex.	OLIG2 GFAP	2.56e-04	10	84	2	38487272
Pubmed	Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.	PLEC GFAP	2.56e-04	10	84	2	19625254
Pubmed	Nkx2.1 regulates the generation of telencephalic astrocytes during embryonic development.	OLIG2 GFAP	2.56e-04	10	84	2	28266561
Pubmed	RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis.	OLIG2 GFAP	2.56e-04	10	84	2	24501358
Pubmed	Cell-type-specific expression of NFIX in the developing and adult cerebellum.	OLIG2 GFAP	2.56e-04	10	84	2	27878595
Pubmed	Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.	OLIG2 GFAP	2.56e-04	10	84	2	11799060
Pubmed	Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon.	OLIG2 GFAP	2.56e-04	10	84	2	20368359
Pubmed	Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.	FANCM TOP3A	2.56e-04	10	84	2	23509288
Pubmed	S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS.	OLIG2 GFAP	2.56e-04	10	84	2	34615523
Pubmed	Diminished Ventral Oligodendrocyte Precursor Generation Results in the Subsequent Over-production of Dorsal Oligodendrocyte Precursors of Aberrant Morphology and Function.	OLIG2 GFAP	2.56e-04	10	84	2	32450295
Pubmed	FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.	FANCM TOP3A	2.56e-04	10	84	2	20064461
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	GAPVD1 COL12A1 TRIO POLA1 SYNPO MTCL1 PLEKHH2 CCDC77	2.64e-04	689	84	8	36543142
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	TANC2 WDR36 CUL9 MTCL1 HERC2 PLEKHH2	2.86e-04	371	84	6	15747579
Pubmed	Netrin-1 is required for the normal development of spinal cord oligodendrocytes.	OLIG2 GFAP	3.13e-04	11	84	2	16481423
Pubmed	γ1 GABAA Receptors in Spinal Nociceptive Circuits.	OLIG2 GFAP	3.13e-04	11	84	2	39137998
Pubmed	NG2 glia are required for vessel network formation during embryonic development.	OLIG2 GFAP	3.13e-04	11	84	2	26651999
Pubmed	Localization of reelin signaling pathway components in murine midbrain and striatum.	OLIG2 GFAP	3.13e-04	11	84	2	25418135
Pubmed	Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain.	OLIG2 GFAP	3.13e-04	11	84	2	23100423
Interaction	CLXN interactions	CLXN HERC2 SNX9	5.76e-06	9	84	3	int:CLXN
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM5 ZSWIM4	3.35e-04	9	56	2	90
Coexpression	PETRETTO_HEART_MASS_QTL_CIS_UP	RPUSD4 TRIO CARD9 PLEC	3.30e-06	32	84	4	M17037
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB5 FREM2 NUGGC SLC25A18 COL12A1 PLEKHH2	5.53e-07	158	84	6	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB5 FREM2 NUGGC SLC25A18 COL12A1 PLEKHH2	5.53e-07	158	84	6	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	facs-Marrow-B-cells-24m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NUGGC CDH23 CCDC106 C1QTNF4 EDEM1	9.08e-07	172	84	6	65b8935a972bf00b7a10dc2d442128fc0ed78bcb
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1S NUGGC CDH23 C1QTNF4 EDEM1	1.62e-05	167	84	5	8ec7a98b542b134f48df8fbec351693cc5cfe55c
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1S NUGGC CDH23 C1QTNF4 EDEM1	1.62e-05	167	84	5	a9f28c4649ce344ae3ba3a3acb58da9c7efad901
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NUGGC CDH23 C1QTNF4 EDEM1	1.71e-05	169	84	5	e348d9877a1bcad4f33dd7b2ce6cb0049583c4d2
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NUGGC CDH23 C1QTNF4 EDEM1	1.71e-05	169	84	5	3167ca0c826244280e0e07d1e02656cf5e4e75a5
ToppCell	facs-Marrow-B-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NUGGC CDH23 CCDC106 EDEM1	1.86e-05	172	84	5	a7fd4d61fb5017dce001d69d6b9a01e6cdf58828
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAD51C POLA1 DHX37 CDT1 TOP3A	1.86e-05	172	84	5	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	facs-Marrow-T-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NUGGC CDH23 C1QTNF4 EDEM1	2.02e-05	175	84	5	0a01e0104cfa3091bc05b0f1d087c941688169a5
ToppCell	facs-Marrow-B-cells-18m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NUGGC ZSWIM5 CDH23 EDEM1	2.08e-05	176	84	5	5f9ae5eb45603ed0422a3a993ecdbe2ce05d6e45
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IQSEC3 EIF3E TNRC6B BEX4 GCK	2.20e-05	178	84	5	73936c2e7e8855b4ab65cad425686513dba331a3
ToppCell	facs-Marrow-T-cells-24m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NUGGC CDH23 C1QTNF4 EDEM1	2.26e-05	179	84	5	3f2934c5f8816a7b7a6aef8d2f83ebf7b2b693bf
ToppCell	AT1_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	COL12A1 SYNPO PLEKHH2 PHLDB2 TMEM139	2.26e-05	179	84	5	1603117b52623663458a977c94bf7f9f6c1114b8
ToppCell	facs-Marrow-T-cells-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NLN NUGGC CDH23 EDEM1	2.38e-05	181	84	5	57f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCell	facs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S NLN NUGGC CDH23 EDEM1	2.38e-05	181	84	5	d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	COL12A1 SYNPO PLEKHH2 PHLDB2 TMEM139	2.51e-05	183	84	5	6821dca076318115d360ff426eb1218cfe104063
ToppCell	AT1_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	KIAA1671 COL12A1 SYNPO TMEM139	2.56e-05	90	84	4	6cbf30dd3992d8ccfaa74ad9781b9f8735f1ef69
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1S FREM2 SLC25A18 NWD1 GFAP	2.71e-05	186	84	5	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NWD1 CLXN MPDZ CC2D2A CFAP74	2.71e-05	186	84	5	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SYNPO GCK MTCL1 DDC GFAP	3.65e-05	198	84	5	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	NS-moderate-d_0-4-Epithelial-Basal\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SYNPO2 POLA1 PHLDB2	4.66e-05	37	84	3	e41e6d3bad3135f3f9109312a2ad6f3206d21d6c
ToppCell	Thalamus-Macroglia-ASTROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	SLC25A18 NWD1 ABCC12 GFAP	8.13e-05	121	84	4	c3a4dfd19b7e8654e859df605d55155b530ad009
ToppCell	Thalamus-Macroglia-ASTROCYTE-Gja1\|Thalamus / BrainAtlas - Mouse McCarroll V32	SLC25A18 NWD1 ABCC12 GFAP	8.13e-05	121	84	4	c3efd44bd01c12ef8c7ce4cc351af1540b70a63c
Disease	Intellectual Disability	TANC2 CSDE1 IQSEC3 TRIO KDM5A BRD4 KLHL15 PUS1	3.81e-05	447	83	8	C3714756
Disease	suicidal ideation	NUGGC WDR36 CDH23	7.44e-05	29	83	3	EFO_0004320
Disease	cystic fibrosis (implicated_via_orthology)	ABCC12 EDEM1	2.78e-04	9	83	2	DOID:1485 (implicated_via_orthology)
Disease	glucose metabolism decline measurement, cingulate cortex measurement	CDH23 TYW1	2.78e-04	9	83	2	EFO_0007738, EFO_0009392
Disease	cardiac troponin T measurement	CACNA1S NUGGC SYNPO2 TRIO CDH23	3.90e-04	219	83	5	EFO_0005043
Disease	Astigmatism	NLN EIF3E MPDZ HERC2	4.91e-04	129	83	4	HP_0000483
Disease	Bone marrow hypocellularity	RAD51C FANCM	1.16e-03	18	83	2	C1855710
Disease	peripheral arterial disease, traffic air pollution measurement	TANC2 VWA8 UBAC2 MTCL1	2.22e-03	194	83	4	EFO_0004265, EFO_0007908
Disease	Fanconi Anemia	RAD51C FANCM	2.25e-03	25	83	2	C0015625
Disease	Neurodevelopmental Disorders	TANC2 TRIO TNRC6B	2.32e-03	93	83	3	C1535926
Disease	Pancytopenia	RAD51C FANCM	2.43e-03	26	83	2	C0030312
Disease	Acute monocytic leukemia	RAD51C FANCM	2.43e-03	26	83	2	C0023465
Disease	uterine fibroid	NLN SLK TNRC6B TOP3A	2.43e-03	199	83	4	EFO_0000731
Disease	Inhalant adrenergic use measurement	WDR36 TRIO UBAC2	2.54e-03	96	83	3	EFO_0009941

Protein segments in the cluster

Peptide	Gene	Start	Entry
RQRVRMADNEVMDAF	TADA3	381	O75528
ARDDVERFVGQMMEI	BEX4	76	Q9NWD9
FVRMVGGRVARMEEQ	BLOC1S4	141	Q9NUP1
KETAARYNAAMGRMR	SH3BP5	181	O60239
RRREAMAATIDMNFQ	BRD4	1336	O60885
TSMKAMEDLGRANRR	ACSL1	246	P33121
TRMAQAREAMDRVKA	APBA3	241	O96018
FAKVQRGVQDMMRRR	CDT1	216	Q9H211
RGVQDMMRRRFEECN	CDT1	221	Q9H211
AMIYDDGASRRREMQ	C1QTNF4	256	Q9BXJ3
EGMRREIFKDRTNKM	CCDC77	381	Q9BR77
EAREMGVIAAMRDGF	CSDE1	346	O75534
MNASEFRRRGKEMVD	DDC	1	P20711
GEARRLRCMEEKEMF	CARD9	311	Q9H257
NKDMAFRMDRISGEI	CDH23	1571	Q9H251
NMSAMERFRNMDKRA	ARPC1A	296	Q92747
LADSRGFRRFMAMDL	NWD1	1111	Q149M9
VFATDEDARLGMMRT	RBM12	46	Q9NTZ6
MRGKTFRFEMQRDLV	RAD51C	1	O43502
KAEMEDMRGQQEREG	MTCL1	596	Q9Y4B5
RRGDFEMDVVAMVND	GCK	191	P35557
TMTEMARRNRAKMGD	LETM2	236	Q2VYF4
AVRMRKAGAMDQRMD	KIAA1671	931	Q9BY89
EVIMDRRLMQDDNRG	MAN2A1	951	Q16706
MRSEDEAKFPTMNRR	PRKCD	131	Q05655
MEMGFSRRNIEFALK	HERC2	2466	O95714
MTRSKNELGRNEDFM	FANCM	396	Q8IYD8
TRQGSAQVMMDFEER	FREM2	2166	Q5SZK8
RKFEIRDMMGLTDDR	GAPVD1	631	Q14C86
GFKETRASERAEMME	GFAP	61	P14136
DRKMMLEDFIRNLRG	IQSEC3	801	Q9UPP2
MSRTLMGGRSERNEF	POLA1	776	P09884
RSDAFNMQMRQRKGT	KDM5A	271	P29375
DRMFGTNRNAISMIR	PLEKHH2	466	Q8IVE3
LLGDREKRMQFFDSM	KCNA10	111	Q16322
FREVIKADMRRQMFA	EFCAB5	376	A4FU69
FRIMFTADMRERDQD	KLHL15	56	Q96M94
AEFSMRGRMREKLQA	CC2D2A	96	Q9P2K1
MNDRSSRRRTMKDDE	CCDC106	1	Q9BWC9
EKGDRGDIASQNMMR	COL12A1	2891	Q99715
EEEAGFTGRRMNSKM	ELOA	546	Q14241
RAMVEAAMEEGIFRR	CACNA1S	1586	Q13698
NDFFRRLLMEDGMQR	SLC25A18	86	Q9H1K4
TRQMQSTRDGRMLFD	EIF3E	101	P60228
RMFRIGEQDHRVDMK	BNIP2	131	Q12982
LRAQMRDLARGMFVF	EDEM1	126	Q92611
KRKMCEMATSGDRQR	MARVELD2	391	Q8N4S9
EMKEAASEMARALRG	CUL9	656	Q8IWT3
DKMGFDEVFMINLRR	COLGALT1	336	Q8NBJ5
GDFMSGRLMALQEDR	HHIPL2	521	Q6UWX4
VRSESRDMDLNYRGM	BTBD9	256	Q96Q07
EANGLRYKAMMEIRR	DHX37	876	Q8IY37
EYMRRRMDAVVALKG	CFAP74	276	Q9C0B2
TEEACMVGRMFKRDG	PATE1	71	Q8WXA2
MDDGKMVKVRRSRNA	RPUSD4	226	Q96CM3
GFESARDVEALMERM	SESN2	251	P58004
TGRFEEEFIKMRMER	SNX9	316	Q9Y5X1
RQVAEGMFERAQERM	NUGGC	696	Q68CJ6
RMAGQSERRASEQMD	TEX55	181	Q96M34
SERRASEQMDRRMSG	TEX55	186	Q96M34
SEQMDRRMSGEAERR	TEX55	191	Q96M34
REQIFRRFEQEMMSK	SLK	856	Q9H2G2
GEDMRKMSFQRCART	PUS1	131	Q9Y606
LEESMARRGSRKSMF	SYNPO	611	Q8N3V7
MRRDVNGVTKSRFEM	FBXL20	1	Q96IG2
RRKMNDFGMAEEFAT	TANC2	1301	Q9HCD6
RERKRMHDLNIAMDG	OLIG2	116	Q13516
MAKDSESRRMLRGYN	PHLDB2	946	Q86SQ0
GRLMNRFSKDMDELD	ABCC12	906	Q96J65
DMIMDRVFRGFDKDN	CLXN	66	Q9HAE3
DKRLSRFDIEMSMRG	NLN	126	Q9BYT8
RRRMEMAFNTRCKEE	NLN	261	Q9BYT8
AKVREMLRMRDSNGA	ZSWIM5	366	Q9P217
GALMFAKRRERMDQI	SYNPO2	491	Q9UMS6
RRGMKQEAELMSRED	MPDZ	461	O75970
LMADFQAGRVTKERM	PLEC	3741	Q15149
FSRAAMEMALRGVRK	TOP3A	21	Q13472
DFRDKMMGRREDSRE	YLPM1	1056	P49750
MLNMQGAEERDIRRE	ZNF502	1	Q8TBZ5
SEEQVARLMEMGFSR	UBAC2	306	Q8NBM4
FRNMGRNEDGERRAM	TYW1	341	Q9NV66
REMQLEDGRFLMSAE	VWA8	196	A3KMH1
RAKLEQRRMASEGSM	TMEM139	136	Q8IV31
RNMGRNEDGERRAMI	TYW1B	296	Q6NUM6
RSGFRKNDEMKAMDV	TRIO	51	O75962
AMNLGDFNDIMRKDR	TNRC6B	1101	Q9UPQ9
GMMLDRKRDFELAQA	WDR36	881	Q8NI36
SKVREMLRMRDSNGA	ZSWIM4	286	Q9H7M6