Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

GTF2IRD2 GTF2IRD2B

1.81e-0543323.90.1460.10
DomainGTF2I

GTF2IRD2 GTF2IRD2B

1.81e-054332IPR004212
DomainGTF2I

GTF2IRD2 GTF2IRD2B

1.81e-054332PS51139
DomainGTF2I

GTF2IRD2 GTF2IRD2B

1.81e-054332PF02946
DomainGAR

MACF1 DST

4.52e-056332PS51460
Domain-

MACF1 DST

4.52e-0563323.30.920.20
Domain-

MACF1 DST

4.52e-0563323.90.1290.10
DomainGAS_dom

MACF1 DST

4.52e-056332IPR003108
DomainGAS2

MACF1 DST

4.52e-056332PF02187
DomainGAS2

MACF1 DST

4.52e-056332SM00243
DomainPlectin_repeat

MACF1 DST

6.32e-057332IPR001101
DomainPlectin

MACF1 DST

6.32e-057332PF00681
DomainPLEC

MACF1 DST

6.32e-057332SM00250
DomainEF-hand-dom_pair

MACF1 DST MICU2 CBLB SCN7A

1.38e-04287335IPR011992
DomainRNaseH-like_dom

GTF2IRD2 GTF2IRD2B RNASEH1

2.43e-0469333IPR012337
DomainActinin_actin-bd_CS

MACF1 DST

7.48e-0423332IPR001589
DomainACTININ_2

MACF1 DST

7.48e-0423332PS00020
DomainACTININ_1

MACF1 DST

7.48e-0423332PS00019
DomainSpectrin

MACF1 DST

7.48e-0423332PF00435
DomainRicin_B_lectin

MRC2 GALNT13

8.85e-0425332PF00652
Domain-

MACF1 DST MICU2 CBLB

1.11e-032613341.10.238.10
DomainRICIN

MRC2 GALNT13

1.11e-0328332SM00458
DomainRICIN_B_LECTIN

MRC2 GALNT13

1.11e-0328332PS50231
DomainSpectrin_repeat

MACF1 DST

1.19e-0329332IPR002017
DomainRicin_B_lectin

MRC2 GALNT13

1.28e-0330332IPR000772
DomainSpectrin/alpha-actinin

MACF1 DST

1.45e-0332332IPR018159
DomainSPEC

MACF1 DST

1.45e-0332332SM00150
DomainEF-hand_1

MACF1 DST MICU2

2.41e-03152333PF00036
DomainEFh

MACF1 DST MICU2

2.69e-03158333SM00054
DomainChannel_four-helix_dom

CACNA1H SCN7A

4.55e-0357332IPR027359
Domain-

CACNA1H SCN7A

4.55e-03573321.20.120.350
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

GTF2IRD2 LARP1 OGDHL MACF1 EEF1D GTF2IRD2B KRT15 DST TOP1MT SMURF2

5.62e-071442331035575683
Pubmed

Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.

MACF1 DST

8.73e-07233211002341
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2 GTF2IRD2B

8.73e-07233215388857
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2 GTF2IRD2B

2.62e-06333215100712
Pubmed

Expression of the mouse Macf2 gene during inner ear development.

MACF1 DST

2.62e-06333212399109
Pubmed

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.

GTF2IRD2 GTF2IRD2B

5.23e-06433221328569
Pubmed

TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.

GTF2IRD2 GTF2IRD2B

5.23e-06433217823943
Pubmed

Evolution of general transcription factors.

GTF2IRD2 GTF2IRD2B

5.23e-06433223229069
Pubmed

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

GTF2IRD2 GTF2IRD2B

5.23e-06433222899722
Pubmed

Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.

MACF1 DST

5.23e-0643328954775
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

CENPP LARP1 MACF1 PLEKHA2 DST

1.47e-0533233537433992
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

LARP1 ACE2 DST MICU2 NRDC DHX34

3.00e-0565033638777146
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

MACF1 EEF1D DST SMURF2

3.18e-0519133433762435
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

LARP1 OGDHL MACF1 EEF1D DST NRDC MYO7A DNAH11

4.46e-05143133837142655
Pubmed

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

MACF1 DST

4.78e-051133216815997
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

GTF2IRD2 LARP1 MACF1 EEF1D GTF2IRD2B KRT15 RNASEH1

8.67e-05115333729845934
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

LARP1 MACF1 DST

1.22e-041013339872452
Pubmed

Transcriptional fates of human-specific segmental duplications in brain.

GTF2IRD2 GTF2IRD2B

1.48e-041933230228200
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

MACF1 DST

1.64e-042033221689717
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

LARP1 MACF1 PLEKHA2 EEF1D DST

1.81e-0456533525468996
Pubmed

LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5.

EEF1D MRC2

1.81e-042133232939012
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

OGDHL TOP1MT RNASEH1 MICU2 NRDC ACO1

2.10e-0492633620877624
Pubmed

Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.

MACF1 CACNA1H

3.02e-042733219026994
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

LARP1 MACF1 KRT15 DST

3.64e-0436033433111431
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

MACF1 DST MRC2

3.98e-0415133317043677
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

ANKRD31 MACF1 DNAH11

4.06e-0415233334299191
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

LARP1 MACF1 PLEKHA2 CACNA1H ANKRD12 SMPDL3B SMURF2

4.17e-04148933728611215
Pubmed

Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.

KRT15 SMARCAL1

4.53e-043333224569637
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

OGDHL CACNA1H DST MYO7A DHX34 SMURF2

5.39e-04110533635748872
Pubmed

Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.

MACF1 EEF1D

5.39e-043633216097034
Pubmed

Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

TOP1MT RNASEH1

5.69e-043733220843780
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

MACF1 PLEKHA2 DST CBLB

6.56e-0442133436976175
Pubmed

In Vitro Reconstitution and Analysis of SARS-CoV-2/Host Protein-Protein Interactions.

LARP1 ACE2

6.66e-044033237483225
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

LARP1 MACF1 EEF1D DST ACO1

9.20e-0480733530575818
Cytoband7q11.23

GTF2IRD2 GTF2IRD2B

2.24e-03973327q11.23
Cytoband8q24.3

EEF1D TOP1MT

3.02e-031133328q24.3
GeneFamilyEF-hand domain containing|Plakins

MACF1 DST

2.61e-058182939
GeneFamilyEF-hand domain containing

MACF1 DST MICU2

1.25e-03219183863
GeneFamilyAnkyrin repeat domain containing

ANKRD31 ANKRD12

2.37e-02242182403
GeneFamilyRing finger proteins

VPS11 CBLB

3.00e-0227518258
CoexpressionLEI_MYB_TARGETS

EEF1D ANKRD12 KRT15 DST NRDC

4.93e-05323335M863
CoexpressionTRAVAGLINI_LUNG_ALVEOLAR_FIBROBLAST_CELL

MACF1 DST MRC2 SCN7A

5.25e-05164334M41676
CoexpressionGSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN

EEF1D TOP1MT GALNT13 SMARCAL1

1.03e-04195334M10022
CoexpressionBLANCO_MELO_BETA_INTERFERON_TREATED_BRONCHIAL_EPITHELIAL_CELLS_UP

ACE2 IRF9 SGMS2 ANKRD12 SMURF2

1.03e-04378335M34022
CoexpressionGSE3982_EFF_MEMORY_CD4_TCELL_VS_TH2_UP

IRF9 MACF1 EEF1D CACNA1H

1.09e-04198334M5580
CoexpressionGSE24634_NAIVE_CD4_TCELL_VS_DAY5_IL4_CONV_TREG_UP

ANKRD12 CBLB SMURF2 MRC2

1.13e-04200334M4588
CoexpressionGSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_IN_MAST_CELL_UP

SMPDL3B RNASEH1 MYO7A MRC2

1.13e-04200334M7333
CoexpressionLAKE_ADULT_KIDNEY_C2_PODOCYTES

MACF1 ANKRD12 DST CBLB

1.42e-04212334M39221
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#4_top-relative-expression-ranked_1000

SGMS2 KRT15 DST

9.95e-0558333gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#4_top-relative-expression-ranked_100

KRT15 DST

1.05e-0410332gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_100_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_100

KRT15 DST

1.28e-0411332gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_100_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#2_top-relative-expression-ranked_100

KRT15 DST

1.28e-0411332DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k2_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#5_top-relative-expression-ranked_100

KRT15 DST

1.53e-0412332gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_100_k5
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

MACF1 PLEKHA2 DST CBLB GALNT13

2.75e-0719033562a3ec1ae0829602b0569cc051210551644f1d46
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST CBLB MRC2 SCN7A

3.12e-071953351cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST CBLB GALNT13 SCN7A

3.29e-071973350034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST CBLB GALNT13 SCN7A

3.29e-0719733511a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

MACF1 ANKRD12 KRT15 CBLB

5.26e-061563341545169694f686d28648a68b552c2ae606599d66
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST CBLB GALNT13

1.24e-05194334b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DST MRC2 SCN7A

1.27e-051953344243190ad291d56694e2155954dbaa879c9d3844
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DST MRC2 SCN7A

1.27e-05195334df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DST MRC2 SCN7A

1.29e-0519633442e9828222a9663525d571633e8a454c30bfa7f8
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DST MRC2 SCN7A

1.29e-05196334cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DST MRC2 SCN7A

1.29e-051963349737a5f006d37b549f281e1863aca558e1e4dc99
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MACF1 DST TOP1MT MRC2

1.32e-05197334fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DST MRC2 SCN7A

1.32e-0519733494a9603cbd3516fbcce871909693b88f20d41713
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST CBLB SCN7A

1.32e-0519733431a1852911bda38543916585fda34255fd62a134
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DST MRC2 SCN7A

1.32e-0519733413896ec65ccda0b928c91d41112dc01b480036b7
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|normal_Lung / Location, Cell class and cell subclass

MACF1 DST MRC2 SCN7A

1.32e-051973346c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MACF1 DST MRC2 SCN7A

1.35e-05198334f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellproximal-mesenchymal-Alveolar_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.37e-051993347f4840ae6a888380feca722543e5e52783f3e35d
ToppCelldistal-mesenchymal-Alveolar_Fibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.37e-05199334fb23ecce41e31e2cc01814e3c0add756f489561f
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

IRF9 MACF1 ANKRD12 CBLB

1.37e-05199334f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellproximal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.37e-05199334301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MACF1 DST MRC2 SCN7A

1.37e-0519933466a79732caf2f04c09b4d9832377aa01ca477677
ToppCellproximal-mesenchymal-Alveolar_Fibroblast-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.37e-051993349a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCelldistal-mesenchymal-Alveolar_Fibroblast|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.37e-05199334655d07cf9a2fd9b945a2ed4f824cba0297de72a8
ToppCellwk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST MRC2 SCN7A

1.37e-051993346bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCellcellseq-Mesenchymal-Fibroblastic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MACF1 DST MRC2 SCN7A

1.40e-052003348978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCellmedial-mesenchymal-Alveolar_Fibroblast-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.40e-052003345c0716bf375c8158f7dc2c82bf5eaf37af594dd0
ToppCellmedial-mesenchymal-Alveolar_Fibroblast|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.40e-05200334c22cbfecee00183dd4be678f116ab9fd9ad0a4dd
ToppCellwk_20-22-Mesenchymal-Fibroblast-Alveolar_fibro|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST MRC2 SCN7A

1.40e-052003340ed49c2177b58269ff7653db6be7d68633a5d34a
ToppCellwk_20-22-Mesenchymal-Fibroblast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MACF1 DST MRC2 SCN7A

1.40e-0520033494bd00fb6ff0dcb668eb36ec2085f1c3128855b6
ToppCellSepsis-ICU-NoSEP-Myeloid-cDC1|ICU-NoSEP / Disease, condition lineage and cell class

DST SMPDL3B TOP1MT MRC2

1.40e-05200334511e642575182fb678df6791ee6539b0ced3eb17
ToppCellmedial-2-mesenchymal-Alveolar_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.40e-05200334cc6062dac07916c29091fc6bee2b864d29e6525b
ToppCelldistal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 DST MRC2 SCN7A

1.40e-0520033420112be28f80baffad92641c9cfd7c3718967dbb
ToppCellControl-PLT_5|World / Disease Group and Platelet Clusters

KRT15 GALNT13 SCN7A

1.10e-041263334ba753c4e83eb1d41964edfa22135e047f06c481
ToppCellBasal|World / shred by cell class for bronchial biopsy

KRT15 DST MRC2

1.29e-04133333d8dd6d0fea5b2c0b1b60b648fa96524027b36e25
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MACF1 ANKRD12 DST

1.35e-04135333b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KRT15 GALNT13 SCN7A

1.38e-0413633327a41463e6f16deb5b1d4f17fefded9959038c07
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT15 GALNT13 SCN7A

1.38e-0413633388b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCellCOVID-19_Moderate-multiplets|COVID-19_Moderate / disease group, cell group and cell class

MACF1 SMPDL3B MRC2

1.74e-04147333baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCell390C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DST MRC2 SCN7A

1.91e-04152333ebce79e106bf1d84241f8dd3496ff1771f9666be
ToppCell390C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DST MRC2 SCN7A

1.91e-041523334a749d1b6d35fd55a8c42d7bd04b6ff5b11ce781
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

TSGA13 DST SCN7A

1.99e-04154333928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

MACF1 SMPDL3B MRC2

2.07e-04156333afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DST TOP1MT MRC2

2.11e-0415733319c0599a669803c4db1f174de1ce755e562a50a3
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 DST SCN7A

2.23e-041603330293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 DST SCN7A

2.23e-041603333eaae86fa08f7651021316f8e5811bf48055591e
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-DC1|bone_marrow / Manually curated celltypes from each tissue

DST MRC2 SCN7A

2.27e-041613332f068ee643de2f647c289779a6624265ab9a749b
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DST TOP1MT MRC2

2.35e-04163333a09449a502627aa369db600dba5bda93de7ce5c0
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

MACF1 PLEKHA2 MRC2

2.35e-04163333f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT15 SMPDL3B SCN7A

2.35e-041633338028636632c168dc50731d0ebecaf88a70daf81d
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DST TOP1MT MRC2

2.39e-04164333ed888b55d9c685096fd785878fcb264f4fee88d6
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DST SMPDL3B MRC2

2.48e-04166333b1bebcbe17386cb102b11d551e62d46156ce0c68
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DST SMPDL3B MRC2

2.52e-04167333e44743b20a7435c579d8e999ddc4ca119d6753f2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DST CBLB SCN7A

2.57e-04168333e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

CBLB MRC2 SCN7A

2.61e-041693336373562ab3b1765060212a6a53d6543e7e942e80
ToppCellControl-B_naive-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MACF1 PLEKHA2 NRDC

2.71e-04171333d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

MACF1 ANKRD12 CBLB

2.71e-041713332e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellcellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

OGDHL KRT15 DST

2.75e-04172333e9095c3dac66cf93d31f5f88364b565abacb1e2d
ToppCellBac-SEP-Myeloid-cDC1|Bac-SEP / Disease, Lineage and Cell Type

DST SMPDL3B MRC2

2.80e-04173333f88269327441858ddb8c49b9dd619b76fd53b1da
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

VPS11 TOP1MT MYO7A

2.95e-04176333437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 GALNT13 DNAH11

2.99e-041773331dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7A SCN7A DNAH11

2.99e-04177333e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DST TOP1MT MRC2

2.99e-04177333e68ad19963a3d8917dfdb81127a41c4fcbe61dd5
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 GALNT13 DNAH11

2.99e-04177333426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCellICU-NoSEP-Myeloid-cDC1|ICU-NoSEP / Disease, Lineage and Cell Type

SMPDL3B TOP1MT MRC2

2.99e-0417733333cd2c183ee8b597012efcbcae72131ac6beaf4e
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

ANKRD12 DST GALNT13

2.99e-04177333e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

CBLB MRC2 SCN7A

3.09e-04179333dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell390C-Fibroblasts-Fibroblast-G|390C / Donor, Lineage, Cell class and subclass (all cells)

DST MRC2 SCN7A

3.15e-04180333137fc14859c89e1ecd98bee388bb58c04b835847
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGMS2 KRT15 DNAH11

3.15e-04180333fc5b9d0e3215652e490ca72d69f776e9725608b2
ToppCell390C-Fibroblasts-Fibroblast-G-|390C / Donor, Lineage, Cell class and subclass (all cells)

DST MRC2 SCN7A

3.15e-04180333cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGMS2 KRT15 DNAH11

3.15e-041803336763b22f2383931c747b37cd0ae2f60b08f64d90
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ACE2 CACNA1H SCN7A

3.20e-0418133333cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

MACF1 ANKRD12 CBLB

3.20e-04181333f2315414e714ac86211546a935660c4be6e85f1b
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OGDHL CBLB SCN7A

3.30e-041833332f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellCOPD-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

SGMS2 DST ACO1

3.35e-041843337fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CBLB MRC2 SCN7A

3.41e-041853338f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 GALNT13 DNAH11

3.46e-0418633316092819e9148dfe64f07c737652b6e533e699f7
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 GALNT13 DNAH11

3.46e-041863334bb54043f944a979db91bde9a86dd66f498c7658
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DST SMPDL3B MYO7A

3.46e-041863337950e03ea080238c168b9d807e217f459acdfb28
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____podocyte-3|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1H KRT15 DNAH11

3.46e-0418633329c79b5a29907d4f3f87ad2ca04840c0f15b7d4e
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DST MRC2 SCN7A

3.46e-041863335473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellRV-07._Pericyte|World / Chamber and Cluster_Paper

ACE2 CACNA1H SCN7A

3.52e-04187333dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSGA13 GALNT13 DNAH11

3.52e-041873331b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

CBLB MRC2 SCN7A

3.52e-041873334ea486991f66c29728d127171a07b81404ec0b78
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SGMS2 DST SCN7A

3.52e-04187333f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellfacs-Kidney-nan-3m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGMS2 KRT15 DST

3.52e-04187333208686e6ebc9f3a774bcbe89274457ac9449f90e
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

MACF1 DST SCN7A

3.52e-0418733392d468dde81125d51daf7abd4703741abe1ab91c
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 DST GALNT13

3.57e-04188333e99e3765b48392c987cf0c5ccbded0655637d7b7
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

MACF1 ANKRD12 CBLB

3.57e-04188333ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 GALNT13 DNAH11

3.63e-04189333ce3fbaf9642785c8adf6edaeae20998bca558928
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DST MYO7A DNAH11

3.63e-0418933398f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SGMS2 DST SCN7A

3.63e-04189333e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DST MYO7A DNAH11

3.63e-04189333f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EEF1D MRC2 DNAH11

3.63e-04189333bd91bdfe35294e60d980259b70fe9e60dca2743f
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

SGMS2 DST ACO1

3.68e-041903332592765016f291565697265800a232b2edef3792
ToppCellIPF-Myeloid-Macrophage_Alveolar|IPF / Disease state, Lineage and Cell class

SGMS2 DST ACO1

3.68e-04190333e539ebc0f4c5ee5dba86c614387be7d91338ad47
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 DST SCN7A

3.68e-04190333d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellCOPD-Myeloid-Macrophage_Alveolar|COPD / Disease state, Lineage and Cell class

SGMS2 DST ACO1

3.68e-04190333006e31606d637033bc81333816ee332773d36b08
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

ACE2 CBLB SCN7A

3.68e-0419033312992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

SGMS2 DST ACO1

3.68e-041903339fc763d65470ba8858b973689c4d4358faab7dd3
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

MACF1 DST SCN7A

1.29e-0449223GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_3
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

MACF1 DST NRDC

1.37e-0450223GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Diseaseunipolar depression, sex interaction measurement

GALNT13 DNAH11

1.49e-0351332EFO_0003761, EFO_0008343
Diseasecancer (implicated_via_orthology)

MACF1 DST TOP1MT

3.30e-03268333DOID:162 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
EFERNRERFEFLKWG

ACO1

146

P21399
MSKFEDFRVFDSWFK

DNAH11

1096

Q96DT5
FDREFWKENFFKSDE

ANKRD12

691

Q6UB98
HFFVEWFEYRKRTFK

CENPP

171

Q6IPU0
IWFDKFKYDDAERRF

EEF1D

11

P29692
ERFNKWENSFLSFVK

ANKRD31

881

Q8N7Z5
FRFWSFFLRDHFNKK

LARP1

916

Q6PKG0
LREFANFDFDIWRKK

DST

7176

Q03001
FFEKTQNKAWFREGF

SMPDL3B

241

Q92485
FRITKADAAEFWRKF

CBLB

171

Q13191
FEDFLARKWSSEKRF

OGDHL

251

Q9ULD0
ELKEFANFDFDVWRK

MACF1

3146

O94854
RREWLRFQEAEYKFF

MRC2

826

Q9UBG0
AEKNRRDVEAWFFSK

KRT15

286

P19012
KEFANFDFDVWRKKY

MACF1

7021

Q9UPN3
RRLAEVWMDEFKDFF

GALNT13

366

Q8IUC8
AWDAQRIFKEAEKFF

ACE2

301

Q9BYF1
REDQDAAFFKAWAIF

IRF9

51

Q00978
RVFQEKWERAYFFVE

GTF2IRD2

426

Q86UP8
RVFQEKWERAYFFVE

GTF2IRD2B

426

Q6EKJ0
FGFRRFFKDRWNQLD

CACNA1H

1671

O95180
ECQKFWTFFERLQRF

DHX34

56

Q14147
VRKSWKRRFFALDDF

PLEKHA2

211

Q9HB19
SFMRKEDFAEWLLFF

MICU2

276

Q8IYU8
QKKRRFEFFDNWDSF

SMARCAL1

936

Q9NZC9
KFFDYIDRVKWAFSV

SGMS2

116

Q8NHU3
ARFKKFATEDEAWAF

RNASEH1

56

O60930
FWKAVEFFDEERRAR

SMURF2

656

Q9HAU4
KREQWFRFSTDNDFK

TSGA13

171

Q96PP4
QWRRFVFFDKELVKE

VPS11

6

Q9H270
TKEVFRKNFFNDWRK

TOP1MT

106

Q969P6
KYFKEALDRWAQFFI

NRDC

281

O43847
SEDDFRKFFQVWKRF

SCN7A

1511

Q01118
FFFDFVRHLTDWIKK

MYO7A

1961

Q13402