Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	TYR CYP7B1 CYP4F2 JMJD6 NOS2	4.64e-05	194	41	5	GO:0016705
GeneOntologyMolecularFunction	monooxygenase activity	TYR CYP7B1 CYP4F2 NOS2	8.97e-05	115	41	4	GO:0004497
GeneOntologyMolecularFunction	cell adhesion molecule binding	CCT8 ITGAL BZW2 NOS2 DSCAML1 PAICS DOCK9	1.95e-04	599	41	7	GO:0050839
GeneOntologyMolecularFunction	cadherin binding	CCT8 BZW2 NOS2 PAICS DOCK9	6.21e-04	339	41	5	GO:0045296
GeneOntologyMolecularFunction	oxidoreductase activity	TYR CYP7B1 CYP4F2 CLIC2 JMJD6 NOS2 DHFR	8.56e-04	766	41	7	GO:0016491
GeneOntologyMolecularFunction	single-stranded RNA binding	LONP1 ILF3 JMJD6	1.53e-03	111	41	3	GO:0003727
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TAOK2 PRKCG PRKG1 CDK13 CPNE3	2.10e-03	446	41	5	GO:0004674
Domain	Copine	CPNE1 CPNE3	1.68e-04	9	41	2	PF07002
Domain	Copine	CPNE1 CPNE3	1.68e-04	9	41	2	IPR010734
Domain	VWFA	CPNE1 ITGAL CPNE3	7.71e-04	82	41	3	PS50234
Domain	VWA	CPNE1 ITGAL CPNE3	8.27e-04	84	41	3	SM00327
Domain	VWF_A	CPNE1 ITGAL CPNE3	1.33e-03	99	41	3	IPR002035
Domain	C2	CPNE1 PRKCG CPNE3	2.96e-03	131	41	3	PF00168
Domain	C2	CPNE1 PRKCG CPNE3	3.36e-03	137	41	3	SM00239
Domain	C2	CPNE1 PRKCG CPNE3	3.71e-03	142	41	3	PS50004
Domain	-	CPNE1 PRKCG CPNE3	4.17e-03	148	41	3	2.60.40.150
Domain	C2_dom	CPNE1 PRKCG CPNE3	5.55e-03	164	41	3	IPR000008
Domain	AGC-kinase_C	PRKCG PRKG1	6.72e-03	56	41	2	IPR000961
Domain	AGC_KINASE_CTER	PRKCG PRKG1	6.72e-03	56	41	2	PS51285
Domain	S_TK_X	PRKCG PRKG1	6.72e-03	56	41	2	SM00133
Domain	CYTOCHROME_P450	CYP7B1 CYP4F2	6.95e-03	57	41	2	PS00086
Domain	-	CYP7B1 CYP4F2	7.19e-03	58	41	2	1.10.630.10
Domain	p450	CYP7B1 CYP4F2	7.19e-03	58	41	2	PF00067
Domain	Ser/Thr_kinase_AS	TAOK2 PRKCG PRKG1 CDK13	7.61e-03	357	41	4	IPR008271
Domain	Cyt_P450	CYP7B1 CYP4F2	7.68e-03	60	41	2	IPR001128
Domain	S_TKc	TAOK2 PRKCG PRKG1 CDK13	7.76e-03	359	41	4	SM00220
Domain	PROTEIN_KINASE_ST	TAOK2 PRKCG PRKG1 CDK13	7.99e-03	362	41	4	PS00108
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	CCT8 CPNE1 SEC22B ILF3 RPLP0 NUP155 BZW2 CLIC2 PAICS	1.10e-07	707	41	9	19738201
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CCT8 CPNE1 LONP1 ILF3 NUP155 MTA3 POLR1E JMJD6 CDK13 CPNE3	2.09e-07	1014	41	10	32416067
Pubmed	A new murine lymphocyte alloantigen, Ly-21.2, mapping to the seventh chromosome.	TYR ITGAL	1.36e-06	2	41	2	6802749
Pubmed	Simulated microgravity promotes nitric oxide-supported angiogenesis via the iNOS-cGMP-PKG pathway in macrovascular endothelial cells.	PRKG1 NOS2	1.36e-06	2	41	2	20600009
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	CPNE1 ILF3 RPLP0 KIF26A POLR1E CDK13	1.88e-06	317	41	6	17620599
Pubmed	Precise mapping of the gene for Ly-21.2 on the 7th chromosome.	TYR ITGAL	4.06e-06	3	41	2	7161508
Pubmed	Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils.	CPNE1 CPNE3	4.06e-06	3	41	2	12949241
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	CCT8 UCK2 LONP1 SEC22B ILF3 RPLP0 NUP155 JMJD6 CDK13 PAICS	4.26e-06	1415	41	10	28515276
Pubmed	Defining the membrane proteome of NK cells.	ARFGEF2 LONP1 ILF3 RPLP0 NUP155 ITGAL BZW2 PAICS DOCK9	7.00e-06	1168	41	9	19946888
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	CCT8 LONP1 SEC22B RPLP0 NUP155 MTA3 CDK13 PAICS	7.30e-06	878	41	8	37223481
Pubmed	Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction.	RAPSN WNT3A	8.12e-06	4	41	2	18541538
Pubmed	Gene mapping of mouse IL-4 receptor: the loci of interleukin 4 (IL-4) receptor gene and lymphocyte function associated antigen 1 (LFA-1) gene are closely linked on chromosome 7.	TYR ITGAL	8.12e-06	4	41	2	1680807
Pubmed	Delayed and acute effects of interferon-gamma on activity of an inwardly rectifying K+ channel in cultured human proximal tubule cells.	PRKG1 NOS2	8.12e-06	4	41	2	18945831
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	CPNE1 LONP1 SEC22B BZW2 PAICS CPNE3	9.67e-06	422	41	6	27342126
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	CCT8 LONP1 NUP155 BZW2 JMJD6 CDK13 PAICS	1.16e-05	665	41	7	30457570
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	CCT8 UCK2 SEC22B ILF3 RPLP0 NUP155 POLR1E PAICS DHFR	1.26e-05	1257	41	9	37317656
Pubmed	A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid.	RPLP0 WNT3A	1.35e-05	5	41	2	8887323
Pubmed	Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting.	CPNE1 CPNE3	1.35e-05	5	41	2	21087455
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	CCT8 CPNE1 LONP1 SEC22B ILF3 RPLP0 NUP155	1.78e-05	711	41	7	33022573
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	CCT8 LONP1 ILF3 RPLP0 POLR1E JMJD6 PAICS DHFR CPNE3	1.84e-05	1318	41	9	30463901
Pubmed	Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling.	RNF31 ITGAL	2.03e-05	6	41	2	26600301
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	CCT8 LONP1 SEC22B ILF3 RPLP0 NUP155 PAICS TTC6 CPNE3	2.03e-05	1335	41	9	29229926
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CCT8 UCK2 LONP1 SEC22B ILF3 RPLP0 NUP155 CPNE3	2.21e-05	1024	41	8	24711643
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CCT8 LONP1 SEC22B ILF3 NUP155 RNF31 POLR1E PAICS CPNE3	2.26e-05	1353	41	9	29467282
Pubmed	Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.	UCK2 LONP1 RPLP0 RNF31 PAICS	2.36e-05	292	41	5	35545034
Pubmed	Activation of annexin 7 by protein kinase C in vitro and in vivo.	PRKCG PRKG1	2.84e-05	7	41	2	11278415
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	UCK2 LONP1 NUP155 PAICS DHFR CPNE3	3.63e-05	534	41	6	35032548
Pubmed	Establishment of the mouse chromosome 7 region with homology to the myotonic dystrophy region of human chromosome 19q.	TYR PRKCG	3.78e-05	8	41	2	1970795
Pubmed	Molecular mapping of the tubby (tub) mutation on mouse chromosome 7.	TYR ITGAL	3.78e-05	8	41	2	8833147
Pubmed	Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation.	CCT8 ILF3 RPLP0 PAICS CPNE3	4.05e-05	327	41	5	34428256
Pubmed	Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling.	CCT8 UCK2 LONP1 BZW2	4.42e-05	166	41	4	34687317
Pubmed	HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.	PRKG1 NOS2	4.86e-05	9	41	2	24666322
Pubmed	The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.	CPNE1 CPNE3	4.86e-05	9	41	2	9430674
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	CCT8 CPNE1 RPLP0 ITGAL PAICS CPNE3	4.97e-05	565	41	6	20458337
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	UCK2 NUP155 BZW2 PAICS DHFR CPNE3	5.26e-05	571	41	6	37167062
Pubmed	Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition.	CPNE1 LONP1 SEC22B NUP155	6.32e-05	182	41	4	36225252
Pubmed	Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells.	UCK2 JMJD6	7.41e-05	11	41	2	31938050
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	CCT8 SEC22B ILF3 RPLP0 GPATCH1	7.73e-05	375	41	5	32788342
Pubmed	Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.	CCT8 UCK2 ILF3 RPLP0 PAICS	7.92e-05	377	41	5	25147182
Pubmed	AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.	CCT8 ILF3 RPLP0 PAICS	9.10e-05	200	41	4	35546148
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CCT8 ILF3 RPLP0 NUP155 MTA3 POLR1E PAICS CPNE3	9.40e-05	1257	41	8	36526897
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	CCT8 SEC22B RPLP0 NUP155 PAICS CPNE3	9.94e-05	641	41	6	36057605
Pubmed	Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.	TYR DHFR	1.22e-04	14	41	2	1354647
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	TYR CYP7B1 NOS2 TTC6 DHFR	1.33e-04	421	41	5	19692168
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	CCT8 LONP1 ILF3 RPLP0 POLR1E CDK13	1.35e-04	678	41	6	30209976
Pubmed	Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.	CCT8 ILF3 PAICS	1.36e-04	84	41	3	19135240
Pubmed	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.	CCT8 ILF3 RPLP0 PAICS	1.41e-04	224	41	4	28443643
Pubmed	Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.	PRKCG WNT3A	1.41e-04	15	41	2	25002511
Pubmed	Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.	LONP1 NUP155 BZW2 DHFR	1.43e-04	225	41	4	31478661
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	CCT8 UCK2 SEC22B DOCK9	1.56e-04	230	41	4	35449600
Pubmed	Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.	CCT8 CPNE1 LONP1	1.61e-04	89	41	3	31267705
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	CCT8 ILF3 RPLP0 POLR1E BZW2 JMJD6	1.66e-04	704	41	6	32994395
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CCT8 ILF3 RPLP0 NUP155 BZW2 PAICS	1.71e-04	708	41	6	39231216
Pubmed	Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.	PRKCG WNT3A	1.82e-04	17	41	2	17199045
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	ILF3 RPLP0 NUP155 CPNE3	1.86e-04	241	41	4	23125841
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	SRL RNF31 ALG1L2 POLR1E PAICS	1.94e-04	457	41	5	32968282
Pubmed	FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.	CCT8 CPNE1 BZW2 PAICS	2.08e-04	248	41	4	32963011
Pubmed	Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.	SEC22B RNF31 DHFR	2.20e-04	99	41	3	31723608
Pubmed	Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.	SLC4A4 NOS2	2.29e-04	19	41	2	24315451
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	NPAS3 PRKG1 DSCAML1	2.34e-04	101	41	3	18519826
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	ARFGEF2 CCT8 RPLP0 NUP155 MTA3 BZW2 JMJD6 PAICS	2.56e-04	1455	41	8	22863883
Pubmed	Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.	UCK2 RPLP0 DHFR	2.62e-04	105	41	3	22505724
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	CCT8 CPNE1 SEC22B RPLP0 GPATCH1	2.63e-04	488	41	5	31324722
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CCT8 CPNE1 ILF3 MTA3 BZW2 CDK13 PAICS	2.77e-04	1103	41	7	34189442
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	ARFGEF2 CCT8 ILF3 NUP155 PAICS	2.78e-04	494	41	5	26831064
Pubmed	The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q.	TYR PRKCG	2.81e-04	21	41	2	2307474
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TAOK2 CCT8 PRKCG LONP1 RPLP0 SLC4A4 DOCK9	3.37e-04	1139	41	7	36417873
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	PRKG1 NOS2	3.38e-04	23	41	2	17954614
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	CCT8 LONP1 ILF3 RPLP0 POLR1E PAICS	3.49e-04	809	41	6	32129710
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	ILF3 MTA3 POLR1E	3.51e-04	116	41	3	21549307
Pubmed	MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.	CCT8 ILF3 PAICS CPNE3	3.62e-04	287	41	4	36180891
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	CCT8 ILF3 RPLP0 MTA3 CDK13 PAICS DOCK9	3.62e-04	1153	41	7	29845934
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	ARFGEF2 CCT8 SEC22B BZW2	3.66e-04	288	41	4	23383273
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 CPNE1 NUP155 MTA3 KIF26A	3.81e-04	529	41	5	14621295
Pubmed	Characterization of Staufen 1 ribonucleoprotein complexes.	ILF3 RPLP0	4.00e-04	25	41	2	15303970
Pubmed	Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.	UCK2 RPLP0 DHFR	4.27e-04	124	41	3	23000965
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	CCT8 SEC22B ILF3 RPLP0 PAICS CPNE3	4.37e-04	844	41	6	25963833
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	UCK2 LONP1 NUP155 MTA3 BZW2	4.94e-04	560	41	5	35241646
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	CCT8 ILF3 RPLP0 POLR1E	5.20e-04	316	41	4	31665637
Pubmed	Global identification of modular cullin-RING ligase substrates.	UCK2 RPLP0 DHFR	5.36e-04	134	41	3	21963094
Pubmed	Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.	TYR ITGAL	5.39e-04	29	41	2	23708969
Pubmed	Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.	CCT8 RPLP0 PAICS	5.71e-04	137	41	3	37039823
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ARFGEF2 CCT8 ILF3 NUP155 CPNE3	5.88e-04	582	41	5	20467437
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	TAOK2 CCT8 RPLP0 NUP155 MTA3	5.92e-04	583	41	5	29844126
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	CCT8 ILF3 RPLP0 GPATCH1	6.11e-04	330	41	4	32529326
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	ILF3 RPLP0 POLR1E DHFR	6.32e-04	333	41	4	36779763
Pubmed	Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.	ILF3 CPNE3	6.58e-04	32	41	2	36252997
Pubmed	ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma.	CCT8 PAICS	7.00e-04	33	41	2	36414381
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	CCT8 RPLP0 PAICS CPNE3	7.14e-04	344	41	4	36282215
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CPNE1 PRKCG SEC22B DOCK9	7.37e-04	347	41	4	17114649
Pubmed	OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.	RNF31 WNT3A	7.87e-04	35	41	2	34157307
Pubmed	A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.	CCT8 RPLP0 PAICS	7.87e-04	153	41	3	27462432
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	CCT8 RPLP0 NUP155 GPATCH1	8.19e-04	357	41	4	37059091
Pubmed	Molecular composition of IMP1 ribonucleoprotein granules.	ILF3 RPLP0	8.33e-04	36	41	2	17289661
Pubmed	Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17.	TYR DHFR	8.33e-04	36	41	2	8094303
Pubmed	Systematic and quantitative assessment of the ubiquitin-modified proteome.	UCK2 RPLP0 DHFR	8.64e-04	158	41	3	21906983
Pubmed	A molecular genetic linkage map of mouse chromosome 7.	TYR PRKCG	8.80e-04	37	41	2	1981054
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CCT8 LONP1 ILF3 NUP155 PAICS	8.88e-04	638	41	5	33239621
Pubmed	Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.	LONP1 SEC22B NUP155	8.96e-04	160	41	3	23798571
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CCT8 SEC22B NUP155 BZW2 PAICS CPNE3	9.25e-04	974	41	6	28675297
Interaction	HUWE1 interactions	CCT8 UCK2 PRKCG ILF3 RPLP0 NUP155 BZW2 NOS2 PAICS DHFR CPNE3	9.23e-06	1110	41	11	int:HUWE1
Interaction	EMC4 interactions	CPNE1 LONP1 SEC22B DEFB106A RPLP0 CPNE3	2.58e-05	292	41	6	int:EMC4
Interaction	FN1 interactions	CCT8 CPNE1 SEC22B ILF3 RPLP0 NUP155 BZW2 CLIC2 PAICS	4.13e-05	848	41	9	int:FN1
Interaction	CDC42 interactions	TAOK2 CPNE1 UCK2 PRKCG LONP1 SEC22B RPLP0 NUP155 BZW2 DOCK9 DHFR	4.73e-05	1323	41	11	int:CDC42
Cytoband	8q21.3	CYP7B1 CPNE3	3.11e-04	29	41	2	8q21.3
GeneFamily	Copines	CPNE1 CPNE3	1.02e-04	9	31	2	829
ToppCell	CV-Moderate-2\|CV / Virus stimulation, Condition and Cluster	CCT8 UCK2 RPLP0 BZW2 PAICS DHFR	2.74e-08	199	41	6	2d98424a5247e87f98095c11fb945289092a9d75
ToppCell	severe-Others-CD34+_GATA2+_cells\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CCT8 ILF3 RPLP0 BZW2 PAICS	8.89e-07	192	41	5	2e80755627d0350be8976324329e106e808d5574
ToppCell	CV-Severe-2\|Severe / Virus stimulation, Condition and Cluster	CCT8 UCK2 RPLP0 BZW2 PAICS	1.03e-06	198	41	5	254659bb53dc2511c714295c2df1ab1fddb2f867
ToppCell	CD8+_Memory_T_cell-CV-2\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	CCT8 UCK2 RPLP0 BZW2 PAICS	1.06e-06	199	41	5	1e33d8e2e0d6a54ef6e2e13f986e19fd209275a8
ToppCell	CV-Moderate-2\|Moderate / Virus stimulation, Condition and Cluster	CCT8 UCK2 RPLP0 BZW2 PAICS	1.06e-06	199	41	5	70d6f2a328eec4cb2cecb7cd85859fba9e15c9c8
ToppCell	BAL-Mild-cDC_11\|Mild / Compartment, Disease Groups and Clusters	ITGAL ALG1L2 DSCAML1 CPNE3	1.55e-05	164	41	4	4bd9629d054545d1e3f9e5c127b5ac2388637106
ToppCell	5'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NOS2 DSCAML1 WNT3A TTC6	2.28e-05	181	41	4	c7a220891567c7539ad5a9ac9db375f0de08ea00
ToppCell	Control-Myeloid-DC_Mature\|Myeloid / Disease state, Lineage and Cell class	UCK2 CYP7B1 CLIC2 DSCAML1	2.54e-05	186	41	4	e9e58c5871b4966cd3586b611703e21af8df6360
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ILF3 RPLP0 BZW2 PAICS	2.76e-05	190	41	4	52c59001a079c76249abbaa3141e9e661b83d9a0
ToppCell	hematopoetic_progenitors-CD34+_CLP\|World / Lineage and Cell class	CCT8 BZW2 PAICS CAPSL	2.82e-05	191	41	4	32f2537c97c9984629d61c6f34a337f555146ad4
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RPLP0 SLC4A4 BZW2 PAICS	2.88e-05	192	41	4	4c9d748f209cc1e13d28c8c7f5180ab8522e0fbf
ToppCell	CV-Severe-2\|CV / Virus stimulation, Condition and Cluster	CCT8 UCK2 BZW2 PAICS	3.06e-05	195	41	4	1cde7f6e6c9c610bacc79014519447112c27dd9d
ToppCell	CV-Moderate-5\|Moderate / Virus stimulation, Condition and Cluster	CCT8 RPLP0 BZW2 PAICS	3.06e-05	195	41	4	646d06ac3fa20acb172735c88cf45e01d212cebf
ToppCell	control-Others-CD34+_GATA2+_cells\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CCT8 RPLP0 BZW2 PAICS	3.12e-05	196	41	4	25994ca143701c72d2f84a3b6d348fcfa1d26a54
ToppCell	Immune_cells-large_pre-B.\|Immune_cells / Lineage and Cell class	UCK2 BZW2 PAICS DHFR	3.24e-05	198	41	4	bc9ceefadb153907d2854d1f736d17349003cb31
ToppCell	CD8+_Memory_T_cell-FLU-2\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	UCK2 BZW2 PAICS DHFR	3.24e-05	198	41	4	9813578a58cdedf68b57a0a5e3cf190c9c25a4cd
ToppCell	Enterocyte_Progenitors\|World / shred on cell type and cluster	ILF3 RPLP0 BZW2 PAICS	3.31e-05	199	41	4	776bcc887927dea9ebd76ec4338ce2225c319c2c
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast\|Megakaryocytic-erythropoietic / Lineage, cell class and subclass	CCT8 ILF3 BZW2 PAICS	3.31e-05	199	41	4	6f159c1215439ec22374903124085746fa8da333
ToppCell	CV-Mild-2\|Mild / Virus stimulation, Condition and Cluster	CCT8 UCK2 BZW2 PAICS	3.31e-05	199	41	4	d88cc07053a852e6c468538a0a851ffa09f97a0d
ToppCell	wk_08-11\|World / Celltypes from embryonic and fetal-stage human lung	CCT8 ILF3 RPLP0 PAICS	3.37e-05	200	41	4	aa35c33762880a5e030a7e691c425524f7dbff8a
Drug	Methylmercury Compounds	CCT8 SRL LONP1 RPLP0 NUP155 BZW2 CLIC2 NOS2 PAICS DHFR	1.54e-06	851	40	10	ctd:D008767
Drug	S-Nitroso-N-Acetylpenicillamine	PRKCG PRKG1 RPLP0 NOS2	4.81e-06	64	40	4	ctd:D026423
Drug	N-Ac-4-S-CAP	TYR DHFR	9.02e-06	3	40	2	CID000124470
Drug	rebamipide	TAOK2 PRKCG NOS2 DHFR	9.07e-06	75	40	4	ctd:C052785
Drug	8-bromoguanosino-3',5'-cyclic monophosphorothioate	PRKG1 NOS2	1.80e-05	4	40	2	ctd:C083763
Drug	4-vinylbenzoate	TYR DHFR	1.80e-05	4	40	2	CID000014098
Drug	GTP - Na	CCT8 UCK2 PRKCG PRKG1 RPLP0 NUP155 POLR1E NOS2 DHFR	2.50e-05	923	40	9	CID000000762
Drug	quinonoid dihydro-(6H)-biopterin	TYR NOS2 DHFR	2.89e-05	34	40	3	CID000000252
Drug	15 Z	TYR NOS2	3.00e-05	5	40	2	CID005322065
Drug	artocarpesin	TYR NOS2	3.00e-05	5	40	2	CID000399491
Drug	metoprine	TYR PRKG1 DHFR	3.45e-05	36	40	3	CID000024466
Drug	iso-H7	PRKCG PRKG1 SLC4A4	3.74e-05	37	40	3	CID000001352
Drug	anemonin	TYR NOS2	4.49e-05	6	40	2	CID000010496
Drug	CCK-J	PRKG1 NOS2	4.49e-05	6	40	2	CID000132626
Drug	8-MOP	TYR CYP7B1 CYP4F2 PAICS	5.42e-05	118	40	4	CID000004114
Drug	2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine	PRKG1 NOS2	6.28e-05	7	40	2	ctd:C459092
Drug	norartocarpetin	TYR NOS2	6.28e-05	7	40	2	CID005481970
Drug	endomorphin-1	PRKCG JMJD6 NOS2	7.24e-05	46	40	3	CID005311080
Drug	PB-3	TAOK2 LONP1 PRKG1	8.22e-05	48	40	3	CID005289109
Drug	X1240	TYR NOS2	8.37e-05	8	40	2	CID005321884
Drug	Triptorelin Pamoate	PRKG1 NOS2	8.37e-05	8	40	2	ctd:D017329
Drug	dieckol	TYR NOS2	8.37e-05	8	40	2	CID003008868
Drug	Nitroglycerin	PRKG1 SLC4A4 NOS2 PAICS	8.64e-05	133	40	4	ctd:D005996
Disease	neuritic plaque measurement	NPAS3 CYP7B1 CYP4F2 PRKG1 CAPSL	9.31e-05	349	39	5	EFO_0006798
Disease	hypertension (biomarker_via_orthology)	CYP4F2 PRKG1 SLC4A4 NOS2	2.27e-04	227	39	4	DOID:10763 (biomarker_via_orthology)
Disease	ankylosing spondylitis	NPAS3 NOS2 CAPSL	2.39e-04	91	39	3	EFO_0003898
Disease	gestational age, birth measurement	NPAS3 RAPSN	3.52e-04	21	39	2	EFO_0005112, EFO_0006921
Disease	impotence (biomarker_via_orthology)	PRKG1 NOS2	3.87e-04	22	39	2	DOID:1875 (biomarker_via_orthology)
Disease	loneliness measurement	ARFGEF2 PRKG1 RAPSN	5.93e-04	124	39	3	EFO_0007865
Disease	nitric oxide exhalation measurement	SLC4A4 NOS2	1.16e-03	38	39	2	EFO_0005536
Disease	Prostatic Neoplasms	UCK2 CYP7B1 RNF31 JMJD6 CPNE3	1.25e-03	616	39	5	C0033578
Disease	Malignant neoplasm of prostate	UCK2 CYP7B1 RNF31 JMJD6 CPNE3	1.25e-03	616	39	5	C0376358
Disease	risky sexual behaviour measurement	CYP7B1 HNF4G KIF26A	1.45e-03	169	39	3	EFO_0007877
Disease	ecosanoids measurement	CYP4F2 RAPSN	2.42e-03	55	39	2	EFO_0020044
Disease	Adenocarcinoma of lung (disorder)	UCK2 SLC4A4 BZW2	2.55e-03	206	39	3	C0152013

Protein segments in the cluster

Peptide	Gene	Start	Entry
AKYFTDAGLKELSDF	BZW2	231	Q9Y6E2
VYDKPASFFKEAPLD	ALG1L2	11	C9J202
APPKANFIEADKYFL	ARFGEF2	56	Q9Y6D5
DNKDLFGKSDPYLEF	CPNE3	151	O75131
DALDFKKDKGAFYLV	CDK13	776	Q14004
VKDYEKALFFPCKAA	RAPSN	176	Q13702
DIFGAVFPYEAKKDR	NOS2	1126	P35228
LLEDYKVPKFFTDDL	JMJD6	146	Q6NYC1
AKAKYEAEAAFFANL	PRKG1	341	Q13976
FAKDPEKQKRYDEFL	GPATCH1	506	Q9BRR8
PTAEKAAFYLDAALA	KIF26A	571	Q9ULI4
VLPAENKKDFYDLAA	LONP1	911	P36776
KFKEPHAAFYAAEIA	PRKCG	451	P05129
LFFLTPAKNAFFDEK	DEFB106A	11	Q8N104
DYTFPLAEKVKAFLA	RPLP0	256	P05388
EYACLKAIVFFDPDA	HNF4G	236	Q14541
TKLYGEFADPFKLAE	NUP155	1186	O75694
VKLFYLDPDAQKLDF	DOCK9	336	Q9BZ29
KFLDNFDSPYDKDGL	CAPSL	161	Q8WWF8
LPLYAKSEAFFRKAD	DSCAML1	1901	Q8TD84
DTFFPEIDLEKYKLL	DHFR	146	P00374
AKAYAALAALEKLFP	ILF3	576	Q12906
INASAAIAPKDKFFY	CYP4F2	111	P78329
ELRDDFLKFDDKFAY	CYP7B1	211	O75881
EAAFPKKLAFAYLED	SEC22B	76	O75396
AAKKYRDFDIPAEFS	CLIC2	196	O15247
KKDFLGKSDPFLEFF	CPNE1	151	Q99829
ASLFEEALEKYGKDF	MTA3	276	Q9BTC8
DAAKPEDVYKFEDLL	POLR1E	206	Q9GZS1
AELFFKDDPEKLFSD	TAOK2	16	Q9UL54
KENFEFYELAKLLPL	NPAS3	66	Q8IXF0
FDFSDYVKRKDPDAL	ITGAL	206	P20701
ESLEPDAYALFHKKL	RNF31	771	Q96EP0
FYPPKVELFFKDDAN	PAICS	121	P22234
ASDYFSKALKFDPEN	TTC6	401	Q86TZ1
SKFDLPNREAYKDFF	SRL	391	Q86TD4
LSAPEKDKFFAYLTL	TYR	126	P14679
PAFEEFCLPTKKYAD	UCK2	191	Q9BZX2
QPDFRAIGDFLKDKY	WNT3A	221	P56704
KRKAPFFASDFYDAL	SLC4A4	451	Q9Y6R1
YAIKKFAEAFEAIPR	CCT8	436	P50990