Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenylate cyclase activity	ADCY4 ADCY2 ADCY7	5.51e-06	18	39	3	GO:0004016
GeneOntologyMolecularFunction	cyclase activity	ADCY4 ADCY2 ADCY7	1.36e-05	24	39	3	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY4 ADCY2 ADCY7	1.54e-05	25	39	3	GO:0016849
GeneOntologyMolecularFunction	lyase activity	ADCY4 FH ADCY2 ADCY7	7.59e-04	212	39	4	GO:0016829
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	ARFGEF3 CCDC88A MYCBP2 ARHGEF5	1.04e-03	231	39	4	GO:0005085
GeneOntologyMolecularFunction	G-protein beta/gamma-subunit complex binding	ADCY4 ADCY2	1.08e-03	25	39	2	GO:0031683
GeneOntologyBiologicalProcess	cAMP biosynthetic process	ADCY4 ADCY2 ADCY7	1.10e-06	11	40	3	GO:0006171
GeneOntologyBiologicalProcess	cyclic nucleotide biosynthetic process	ADCY4 ADCY2 ADCY7	1.16e-05	23	40	3	GO:0009190
GeneOntologyBiologicalProcess	cAMP metabolic process	ADCY4 ADCY2 ADCY7	1.51e-05	25	40	3	GO:0046058
GeneOntologyBiologicalProcess	activation of adenylate cyclase activity	ADCY4 ADCY2 ADCY7	3.88e-05	34	40	3	GO:0007190
GeneOntologyBiologicalProcess	positive regulation of adenylate cyclase activity	ADCY4 ADCY2 ADCY7	6.35e-05	40	40	3	GO:0045762
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	ADCY4 ADCY2 ADCY7	8.47e-05	44	40	3	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	ADCY4 ADCY2 ADCY7	9.06e-05	45	40	3	GO:0009187
GeneOntologyBiologicalProcess	positive regulation of lymphocyte activation	ADK ARID1A LYST GLI2 HLA-DRB1 SPTA1	9.13e-05	385	40	6	GO:0051251
GeneOntologyBiologicalProcess	positive regulation of cyclase activity	ADCY4 ADCY2 ADCY7	1.10e-04	48	40	3	GO:0031281
GeneOntologyBiologicalProcess	positive regulation of lyase activity	ADCY4 ADCY2 ADCY7	1.17e-04	49	40	3	GO:0051349
GeneOntologyBiologicalProcess	positive regulation of leukocyte activation	ADK ARID1A LYST GLI2 HLA-DRB1 SPTA1	1.53e-04	423	40	6	GO:0002696
GeneOntologyBiologicalProcess	regulation of adenylate cyclase activity	ADCY4 ADCY2 ADCY7	2.04e-04	59	40	3	GO:0045761
GeneOntologyBiologicalProcess	positive regulation of cell activation	ADK ARID1A LYST GLI2 HLA-DRB1 SPTA1	2.11e-04	449	40	6	GO:0050867
GeneOntologyBiologicalProcess	positive regulation of T cell activation	ADK ARID1A GLI2 HLA-DRB1 SPTA1	2.33e-04	290	40	5	GO:0050870
GeneOntologyBiologicalProcess	regulation of cyclase activity	ADCY4 ADCY2 ADCY7	3.24e-04	69	40	3	GO:0031279
GeneOntologyBiologicalProcess	positive regulation of leukocyte cell-cell adhesion	ADK ARID1A GLI2 HLA-DRB1 SPTA1	3.52e-04	317	40	5	GO:1903039
GeneOntologyBiologicalProcess	regulation of lyase activity	ADCY4 ADCY2 ADCY7	3.82e-04	73	40	3	GO:0051339
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ADCY4 ADCY2 ADCY7	6.18e-04	86	40	3	GO:0007193
Domain	Adcy_conserved_dom	ADCY4 ADCY2 ADCY7	1.81e-07	6	40	3	IPR009398
Domain	DUF1053	ADCY4 ADCY2 ADCY7	1.81e-07	6	40	3	PF06327
Domain	AC_N	ADCY4 ADCY2 ADCY7	5.06e-07	8	40	3	IPR032628
Domain	Adcy	ADCY4 ADCY2 ADCY7	5.06e-07	8	40	3	IPR030672
Domain	AC_N	ADCY4 ADCY2 ADCY7	5.06e-07	8	40	3	PF16214
Domain	A/G_cyclase_CS	ADCY4 ADCY2 ADCY7	6.06e-06	17	40	3	IPR018297
Domain	Nucleotide_cyclase	ADCY4 ADCY2 ADCY7	7.26e-06	18	40	3	IPR029787
Domain	-	ADCY4 ADCY2 ADCY7	7.26e-06	18	40	3	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY4 ADCY2 ADCY7	8.61e-06	19	40	3	PS00452
Domain	Guanylate_cyc	ADCY4 ADCY2 ADCY7	8.61e-06	19	40	3	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY4 ADCY2 ADCY7	8.61e-06	19	40	3	PS50125
Domain	A/G_cyclase	ADCY4 ADCY2 ADCY7	8.61e-06	19	40	3	IPR001054
Domain	CYCc	ADCY4 ADCY2 ADCY7	8.61e-06	19	40	3	SM00044
Domain	PH-BEACH_dom	WDFY4 LYST	1.24e-04	8	40	2	IPR023362
Domain	-	WDFY4 LYST	1.24e-04	8	40	2	2.30.29.40
Domain	PH_BEACH	WDFY4 LYST	1.24e-04	8	40	2	PS51783
Domain	BEACH_dom	WDFY4 LYST	1.59e-04	9	40	2	IPR000409
Domain	BEACH	WDFY4 LYST	1.59e-04	9	40	2	PS50197
Domain	Beach	WDFY4 LYST	1.59e-04	9	40	2	PF02138
Domain	-	WDFY4 LYST	1.59e-04	9	40	2	1.10.1540.10
Domain	Beach	WDFY4 LYST	1.59e-04	9	40	2	SM01026
Domain	ARM-type_fold	ARFGEF3 MMS19 ARID1A WDFY4 LYST	7.47e-04	339	40	5	IPR016024
Domain	Ig_E-set	CPAMD8 SUOX MYCBP2	1.43e-03	104	40	3	IPR014756
Pathway	KEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY	ADCY4 ARID1A ADCY2 ADCY7	9.55e-07	35	31	4	M47969
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY4 ADCY2 ADCY7	1.14e-06	10	31	3	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY4 ADCY2 ADCY7	1.14e-06	10	31	3	MM14668
Pathway	WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY	ADCY4 ADCY2 ADCY7 SUN1	2.93e-06	46	31	4	M39828
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY4 ADCY2 ADCY7	3.45e-06	14	31	3	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY4 ADCY2 ADCY7	3.45e-06	14	31	3	M750
Pathway	WP_THERMOGENESIS	MGLL ADCY4 ARID1A ADCY2 ADCY7	3.49e-06	108	31	5	M39746
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	4.30e-06	15	31	3	M47794
Pathway	PID_LPA4_PATHWAY	ADCY4 ADCY2 ADCY7	4.30e-06	15	31	3	M56
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	4.30e-06	15	31	3	M47504
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY4 ADCY2 ADCY7	5.29e-06	16	31	3	M39849
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	5.29e-06	16	31	3	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	5.29e-06	16	31	3	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY4 ADCY2 ADCY7	5.29e-06	16	31	3	MM14492
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY4 ADCY2 ADCY7	6.41e-06	17	31	3	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	6.41e-06	17	31	3	M47544
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY4 ADCY2 ADCY7	1.07e-05	20	31	3	M759
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	1.89e-05	24	31	3	M47520
Pathway	KEGG_PURINE_METABOLISM	ADK ADCY4 POLR3B ADCY2 ADCY7	2.30e-05	159	31	5	M14314
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	2.42e-05	26	31	3	M47553
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY4 ADCY2 ADCY7	2.42e-05	26	31	3	MM14495
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	2.72e-05	27	31	3	M47518
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	2.72e-05	27	31	3	M47519
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	3.04e-05	28	31	3	M47647
Pathway	WP_PURINE_METABOLISM	ADK ADCY4 POLR3B ADCY2 ADCY7	3.26e-05	171	31	5	MM15909
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	3.38e-05	29	31	3	M47515
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	3.38e-05	29	31	3	M47627
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	4.15e-05	31	31	3	M47507
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	4.57e-05	32	31	3	M47506
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	ADCY4 ADCY2 ADCY7	5.02e-05	33	31	3	MM15058
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	ADCY4 ADCY2 ADCY7	5.02e-05	33	31	3	M11575
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY4 ADCY2 ADCY7	7.11e-05	37	31	3	M749
Pathway	REACTOME_HEDGEHOG_OFF_STATE	ADCY4 ADCY2 GLI2 ADCY7	7.83e-05	105	31	4	MM15206
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY4 ADCY2 ADCY7	8.34e-05	39	31	3	MM14496
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ADCY4 ADCY2 ADCY7 IQGAP1	8.74e-05	108	31	4	M17034
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ADCY4 ADCY2 ADCY7	9.70e-05	41	31	3	M512
Pathway	REACTOME_HEDGEHOG_OFF_STATE	ADCY4 ADCY2 GLI2 ADCY7	1.04e-04	113	31	4	M27471
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	ADCY4 ADCY2 ADCY7	1.12e-04	43	31	3	M29837
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	ADCY4 ADCY2 ADCY7	1.12e-04	43	31	3	M933
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	ADCY4 ADCY2 ADCY7	1.12e-04	43	31	3	M954
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	ADCY4 ADCY2 ADCY7	1.20e-04	44	31	3	MM15709
Pathway	REACTOME_GPER1_SIGNALING	ADCY4 ADCY2 ADCY7	1.28e-04	45	31	3	M45008
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	ADCY4 ADCY2 ADCY7	1.56e-04	48	31	3	M10775
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	ADCY4 ADCY2 ADCY7	1.98e-04	52	31	3	M920
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	ADCY4 ADCY2 GLI2 ADCY7	2.19e-04	137	31	4	MM15182
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY4 ADCY2 ADCY7	2.21e-04	54	31	3	M26911
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	ADCY4 ADCY2 ADCY7	2.34e-04	55	31	3	M39763
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	ADCY4 ADCY2 ADCY7	3.03e-04	60	31	3	M976
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	ADCY4 ADCY2 ADCY7	3.03e-04	60	31	3	MM15708
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	ADCY4 ADCY2 GLI2 ADCY7	3.10e-04	150	31	4	M27440
Pathway	PID_ENDOTHELIN_PATHWAY	ADCY4 ADCY2 ADCY7	3.50e-04	63	31	3	M8
Pathway	PID_LYSOPHOSPHOLIPID_PATHWAY	ADCY4 ADCY2 ADCY7	3.84e-04	65	31	3	M15
Pathway	REACTOME_OPIOID_SIGNALLING	ADCY4 ADCY2 ADCY7	4.97e-04	71	31	3	MM14491
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	ADCY4 ADCY2 ADCY7	8.42e-04	85	31	3	M3578
Pathway	KEGG_GAP_JUNCTION	ADCY4 ADCY2 ADCY7	9.94e-04	90	31	3	M4013
Pathway	REACTOME_OPIOID_SIGNALLING	ADCY4 ADCY2 ADCY7	9.94e-04	90	31	3	M6467
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	ADCY4 ADCY2 ADCY7	9.94e-04	90	31	3	MM15882
Pathway	KEGG_DILATED_CARDIOMYOPATHY	ADCY4 ADCY2 ADCY7	9.94e-04	90	31	3	M835
Pathway	WP_G_PROTEIN_SIGNALING	ADCY4 ADCY2 ADCY7	1.03e-03	91	31	3	M39426
Pathway	REACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS	ADCY4 ADCY2 ADCY7	1.16e-03	95	31	3	M29842
Pathway	KEGG_MELANOGENESIS	ADCY4 ADCY2 ADCY7	1.39e-03	101	31	3	M7761
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	1.39e-03	101	31	3	M1979
Pathway	KEGG_OOCYTE_MEIOSIS	ADCY4 ADCY2 ADCY7	1.91e-03	113	31	3	M16817
Pathway	WP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS	ADCY4 ADCY2	1.96e-03	30	31	2	M42578
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	ADCY4 ADCY2 ADCY7	2.01e-03	115	31	3	M9387
Pathway	WP_TUMOR_SUPPRESSOR_ACTIVITY_OF_SMARCB1	ARID1A GLI2	2.09e-03	31	31	2	M39522
Pathway	REACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION	ADCY4 ADCY2 ADCY7	3.11e-03	134	31	3	M29840
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	ADCY4 ADCY2 ADCY7	3.81e-03	144	31	3	MM14501
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	ADCY4 ADCY2 ADCY7	4.03e-03	147	31	3	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	ADCY4 ADCY2 ADCY7	4.35e-03	151	31	3	M39329
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	ADCY4 ADCY2 ADCY7	4.59e-03	154	31	3	MM15974
Pathway	WP_CANCER_PATHWAYS	ADCY4 FH ADCY2 GLI2 ADCY7	4.62e-03	507	31	5	M48302
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	ADCY4 ADCY2 ADCY7	4.76e-03	156	31	3	M39475
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	ADCY4 ADCY2 ADCY7	4.85e-03	157	31	3	M4904
Pathway	WP_CHEMOKINE_SIGNALING	ADCY4 ADCY2 ADCY7	5.56e-03	165	31	3	M39400
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	6.86e-03	178	31	3	M2890
Pathway	WP_CHEMOKINE_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	7.52e-03	184	31	3	MM15943
Pathway	KEGG_CHEMOKINE_SIGNALING_PATHWAY	ADCY4 ADCY2 ADCY7	7.97e-03	188	31	3	M4844
Pubmed	Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.	ADCY4 ADCY2 ADCY7	4.92e-08	7	40	3	38109525
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY4 ADCY2 ADCY7	1.18e-07	9	40	3	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY4 ADCY2 ADCY7	1.18e-07	9	40	3	12503609
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY4 ADCY2 ADCY7	1.18e-07	9	40	3	17229090
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY4 ADCY2 ADCY7	1.68e-07	10	40	3	8663304
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY4 ADCY2 ADCY7	1.68e-07	10	40	3	16615126
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY4 ADCY2 ADCY7	1.68e-07	10	40	3	11884542
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY4 ADCY2 ADCY7	2.31e-07	11	40	3	11299302
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY4 ADCY2 ADCY7	2.31e-07	11	40	3	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY4 ADCY2 ADCY7	2.31e-07	11	40	3	10808179
Pubmed	Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.	ADCY4 ADCY2 ADCY7	3.08e-07	12	40	3	9611134
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY4 ADCY2 ADCY7	3.08e-07	12	40	3	10807185
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY4 ADCY2 ADCY7	5.08e-07	14	40	3	14993377
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY4 ADCY2 ADCY7	6.35e-07	15	40	3	2165385
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY4 ADCY2 ADCY7	7.81e-07	16	40	3	17567809
Pubmed	Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus.	ADCY4 ADCY2	1.29e-06	2	40	2	9870949
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZBTB10 FLII MMS19 POLR3B URB2 ARID1A ANKHD1 MGA MYCBP2 IQGAP1	2.24e-06	1353	40	10	29467282
Pubmed	Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.	FLII IQGAP1	3.87e-06	3	40	2	32432944
Pubmed	Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis.	FLII IQGAP1	3.87e-06	3	40	2	32643295
Pubmed	Glucagon and regulation of glucose metabolism.	ADCY4 ADCY2 ADCY7	6.19e-06	31	40	3	12626323
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZBTB10 CCDC88A ANKHD1 MGA MYCBP2 ZMIZ2	7.90e-06	418	40	6	34709266
Pubmed	Mapping of the bcl-2 oncogene on mouse chromosome 1.	REN SPTA1	1.29e-05	5	40	2	2895697
Pubmed	Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.	ADCY4 ADCY2	1.29e-05	5	40	2	21228062
Pubmed	Mammalian adenylyl cyclase family members are randomly located on different chromosomes.	ADCY4 ADCY2	1.29e-05	5	40	2	7959689
Pubmed	Novel associations for hypothyroidism include known autoimmune risk loci.	ZBTB10 SACS HLA-DRB1	1.81e-05	44	40	3	22493691
Pubmed	Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.	ADCY4 ADCY2	1.93e-05	6	40	2	7766992
Pubmed	Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.	ADCY4 ADCY2	1.93e-05	6	40	2	11549699
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY4 ADCY2	2.70e-05	7	40	2	12613887
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLII ZNF395 ARID1A ANKHD1 MYCBP2 LYST ADCY7 ZMIZ2	3.15e-05	1105	40	8	35748872
Pubmed	Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group.	REN SPTA1	4.62e-05	9	40	2	2894402
Pubmed	Receptors for Fc epsilon and Fc gamma are linked on mouse chromosome 1.	REN SPTA1	4.62e-05	9	40	2	2971731
Pubmed	Mapping of alpha-spectrin on distal mouse chromosome 1.	REN SPTA1	4.62e-05	9	40	2	2885153
Pubmed	Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q.	REN SPTA1	5.77e-05	10	40	2	3384439
Pubmed	A molecular genetic approach to gld "autoimmune" disease.	REN SPTA1	5.77e-05	10	40	2	3416634
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	ARFGEF3 MMS19 COG1 ARHGEF5	5.85e-05	183	40	4	23956138
Pubmed	Variation within DNA repair pathway genes and risk of multiple sclerosis.	RAD51D MMS19 HLA-DRB1	7.95e-05	72	40	3	20522537
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII POLR3B ARID1A MYCBP2 COG1 SACS HLA-DRB1 IQGAP1	9.11e-05	1285	40	8	35914814
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MGA MYCBP2 SACS	9.35e-05	76	40	3	27542412
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	URB2 FH ARID1A ANKHD1 MYCBP2 IQGAP1	9.55e-05	653	40	6	22586326
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	ARID1A MGA IQGAP1	1.05e-04	79	40	3	26446488
Pubmed	Mechanism of GTP hydrolysis by G-protein alpha subunits.	ADCY2 ADCY7	1.34e-04	15	40	2	7937899
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII URB2 MGA MYCBP2 SACS SUN1 IQGAP1	1.50e-04	1024	40	7	24711643
Pubmed	HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway.	LYST HLA-DRB1	1.95e-04	18	40	2	19620308
Pubmed	Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.	WDFY4 HLA-DRB1	1.95e-04	18	40	2	19838193
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	REN WDFY4 ADCY2	2.17e-04	101	40	3	18519826
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MED12L WDFY4 ZNF529	2.17e-04	101	40	3	10997877
Pubmed	Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells.	CLCA1 ADCY7	2.18e-04	19	40	2	25855264
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARFGEF3 CPAMD8 CCDC88A	2.30e-04	103	40	3	10574462
Pubmed	Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.	REN SPTA1	2.67e-04	21	40	2	1970330
Pubmed	Genetics of rheumatoid arthritis contributes to biology and drug discovery.	SUOX WDFY4 HLA-DRB1	2.94e-04	112	40	3	24390342
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MED12L CCDC88A ANKHD1 SUN1 IQGAP1	3.39e-04	529	40	5	14621295
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	FLII MMS19 IQGAP1	3.61e-04	120	40	3	27320910
Pubmed	Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1.	REN SPTA1	4.45e-04	27	40	2	2574151
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	ADK UBA5 MMS19 FH COG1 IQGAP1	4.69e-04	878	40	6	37223481
Pubmed	Characterization of the piRNA complex from rat testes.	ZBTB10 RAD51D MGLL	5.66e-04	140	40	3	16778019
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	CCDC88A ARID1A SPTA1	6.52e-04	147	40	3	16959763
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ARFGEF3 MMS19 URB2 COG1 SUN1 IQGAP1	6.79e-04	942	40	6	31073040
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	UBA5 FLII ANKHD1 IQGAP1	7.69e-04	360	40	4	33111431
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	CCDC88A WDFY4 IQGAP1	7.74e-04	156	40	3	30409884
Pubmed	Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.	MGA WDFY4 SUN1	7.89e-04	157	40	3	12466305
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	RAD51D MMS19 ARID1A	7.89e-04	157	40	3	30686591
Pubmed	Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.	ZBTB10 MMS19	7.93e-04	36	40	2	24035498
Pubmed	HSP90 Shapes the Consequences of Human Genetic Variation.	RAD51D MMS19	7.93e-04	36	40	2	28215707
Pubmed	Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.	CLCA1 GLI2	8.37e-04	37	40	2	23266329
Pubmed	Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.	WDFY4 HLA-DRB1	8.83e-04	38	40	2	23273568
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	ARID1A GLI2	9.30e-04	39	40	2	25859222
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLII ADCY4 FH ARID1A SACS SPTA1 IQGAP1	1.11e-03	1431	40	7	37142655
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	FLII ARID1A MGA ZMIZ2	1.11e-03	398	40	4	35016035
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY4 ADCY2 ADCY7	4.42e-07	10	29	3	53
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY4 LYST	8.88e-05	9	29	2	1230
Coexpression	GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_DN	ZNF395 POLR3B URB2 MGA MYCBP2	1.24e-05	198	40	5	M6033
Coexpression	GSE18281_SUBCAPSULAR_VS_PERIMEDULLARY_CORTICAL_REGION_OF_THYMUS_UP	MGLL MMS19 SUOX ADCY7 HLA-DRB1	1.30e-05	200	40	5	M7235
CoexpressionAtlas	DevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#4_top-relative-expression-ranked_500	MED12L MGLL MYCBP2 IQGAP1	4.67e-05	106	40	4	gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500_k4
CoexpressionAtlas	Myeloid Cells, DC.4+.Sp, CD11b CD45 CD4 CD11c CD8a, Spleen, avg-1	CCDC88A MYCBP2 WDFY4 LYST HLA-DRB1 ZMIZ2	7.46e-05	382	40	6	GSM538248_500
CoexpressionAtlas	DevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_500	REN ZNF395 ARID1A MGA ADCY7 SUN1	1.07e-04	408	40	6	gudmap_developingGonad_P2_testes_500
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_500	REN ZNF395 ARID1A MGA ADCY7 SUN1	1.13e-04	412	40	6	gudmap_developingGonad_e18.5_testes_500
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_top-relative-expression-ranked_1000	REN ZNF395 CLCA1 ARID1A MGA SACS ADCY7 SUN1	1.22e-04	819	40	8	gudmap_developingGonad_e16.5_testes_1000
ToppCell	COVID-19-APC-like-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	MED12L CCDC88A WDFY4 ADCY7 HLA-DRB1	6.18e-07	183	40	5	703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCell	COVID-19-APC-like\|COVID-19 / group, cell type (main and fine annotations)	MED12L CCDC88A WDFY4 ADCY7 HLA-DRB1	6.18e-07	183	40	5	b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MED12L CCDC88A WDFY4 SPTA1	1.21e-05	158	40	4	f61ebe3a316e4259387cd9da83707f15e6473cae
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	MED12L ARID1A MGA WDFY4	1.34e-05	162	40	4	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88A WDFY4 ADCY7 HLA-DRB1	1.58e-05	169	40	4	da3485d77bb7876fad4f166f6099e681b27457ae
ToppCell	Immune-dendritic_cell\|World / Lineage, Cell type, age group and donor	MED12L CCDC88A WDFY4 HLA-DRB1	1.65e-05	171	40	4	6a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	1.73e-05	173	40	4	73f858f2c45d19b9ec8d99ac02c91551790f670c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADK WDFY4 LYST HLA-DRB1	1.73e-05	173	40	4	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	1.85e-05	176	40	4	5f8c1f917fba49f3b1c0d88b946eca242b668fde
ToppCell	3'_v3-blood-Hematopoietic_progenitors\|blood / Manually curated celltypes from each tissue	MED12L MGLL REN SPTA1	1.89e-05	177	40	4	22c77077951889e63489abfabf90900655655c82
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MED12L CCDC88A WDFY4 HLA-DRB1	1.89e-05	177	40	4	c5e829bc4594761666d65cace5a9c5d19c16f187
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A MYCBP2 LYST IQGAP1	2.11e-05	182	40	4	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	Control-APC-like-Dendritic_cells\|Control / group, cell type (main and fine annotations)	MED12L CCDC88A WDFY4 HLA-DRB1	2.16e-05	183	40	4	8f9c8e2436f18ea7c265b08e4e149e19cb513a16
ToppCell	Control-APC-like\|Control / group, cell type (main and fine annotations)	MED12L CCDC88A WDFY4 HLA-DRB1	2.16e-05	183	40	4	c313ac72cc9fa1583456d452393f61f0a4ca33a8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.21e-05	184	40	4	4f4aeef3b821a003e857fe4a195124d44b2d7479
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A MYCBP2 LYST IQGAP1	2.21e-05	184	40	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A MYCBP2 LYST IQGAP1	2.25e-05	185	40	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.30e-05	186	40	4	305f1726b8b5add32f1c29c74991ff34f42e0da7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB10 ADK WDFY4 HLA-DRB1	2.40e-05	188	40	4	d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	WDFY4 LYST HLA-DRB1 IQGAP1	2.45e-05	189	40	4	b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADK MYCBP2 LYST HLA-DRB1	2.50e-05	190	40	4	a7498fe55b7810c482291db782dc5282675d246a
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-GC_B_(II)\|GI_large-bowel / Manually curated celltypes from each tissue	MED12L CCDC88A WDFY4 HLA-DRB1	2.50e-05	190	40	4	fee64bacbb330d04dc1dc63909838f2c605d9f1f
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	MGLL CCDC88A WDFY4 HLA-DRB1	2.50e-05	190	40	4	6892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MYCBP2 LYST SUN1 IQGAP1	2.55e-05	191	40	4	9454f642c3621370fa23640b631301346b300950
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.66e-05	193	40	4	3e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	MYCBP2 WDFY4 HLA-DRB1 SUN1	2.66e-05	193	40	4	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB10 ADK WDFY4 HLA-DRB1	2.66e-05	193	40	4	ac227ddabfb3f021b1b39dba73f898517cd5a58e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB10 ADK WDFY4 HLA-DRB1	2.66e-05	193	40	4	f4135615ee0118eec9e221becdd67888e0c2a112
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	MGLL CPAMD8 ADCY4 HLA-DRB1	2.66e-05	193	40	4	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYCBP2 WDFY4 LYST HLA-DRB1	2.71e-05	194	40	4	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	MGLL CPAMD8 ADCY4 HLA-DRB1	2.71e-05	194	40	4	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	MGLL CPAMD8 ADCY4 HLA-DRB1	2.77e-05	195	40	4	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.82e-05	196	40	4	291c59b609985167c98a40d4e2caeea2fad74941
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	MGLL CPAMD8 ADCY4 HLA-DRB1	2.88e-05	197	40	4	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.88e-05	197	40	4	dea1d29154c585ab588e50b83c7c8de7fe24d2d4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.88e-05	197	40	4	57dafb3047745a44b2345b8036e159c3641d496e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.88e-05	197	40	4	826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCell	Dendritic_cell\|World / shred by cell class for turbinate	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.88e-05	197	40	4	ab2213e3742f92798922ea318d76328b6ca18b13
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.88e-05	197	40	4	72cd61b868d57862ec9c230ea68913d3829b0f2b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.88e-05	197	40	4	d95565652ca318a2298d6918d54ba6367e9560f4
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MED12L CCDC88A WDFY4 HLA-DRB1	2.94e-05	198	40	4	fa5c15a656d4132950092919600e270f1fd79abf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.94e-05	198	40	4	96883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCell	COVID-19-kidney-Macrophages\|kidney / Disease (COVID-19 only), tissue and cell type	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.94e-05	198	40	4	161324541fe5da5cbb58142ea94fefd39b7dfb04
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	2.94e-05	198	40	4	623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7 HLA-DRB1	3.00e-05	199	40	4	04adf46975aa4194ea40c7480f8a517def5d929c
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ZBTB10 CCDC88A LYST HLA-DRB1	3.00e-05	199	40	4	7b3d4c62b11268c7c1599600d8a7b331287cf21a
ToppCell	severe-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZBTB10 ADK WDFY4 HLA-DRB1	3.05e-05	200	40	4	0e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B-B_naive\|COVID-19_Severe / Disease, condition lineage and cell class	ZBTB10 ADK WDFY4 HLA-DRB1	3.05e-05	200	40	4	5ba9c541fa356d34f392a63274dcd7bfb844cbb6
ToppCell	mild-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZBTB10 ADK WDFY4 HLA-DRB1	3.05e-05	200	40	4	222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCell	severe-B_naive\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZBTB10 ADK WDFY4 HLA-DRB1	3.05e-05	200	40	4	306df1f498ac2188eaf9f2a8d002bb73bdb9642d
ToppCell	mild-B_naive\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZBTB10 ADK WDFY4 HLA-DRB1	3.05e-05	200	40	4	d0467cab6a42bf780aa49046bf3231ca161dc144
ToppCell	PBMC-Severe-cDC_1\|Severe / Compartment, Disease Groups and Clusters	ADCY4 WDFY4 IQGAP1	5.29e-05	81	40	3	6d1e524f000b71c935359afc801a1d31f218fec8
ToppCell	severe-Lymphocytic-B_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	REN WDFY4 HLA-DRB1	2.46e-04	136	40	3	56a7b5c2e098b4a49124d1b905257a52eb38b519
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MED12L WDFY4 SPTA1	2.68e-04	140	40	3	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma\|TCGA-Uterus / Sample_Type by Project: Shred V9	ARFGEF3 MGLL LYST	3.34e-04	151	40	3	2810bfa01bd3016aeba29735eb4a9284792e8aac
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MED12L WDFY4 HLA-DRB1	3.61e-04	155	40	3	9f937ae48767fdcf1a944af4de0530d9c0ab441d
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADK WDFY4 HLA-DRB1	3.68e-04	156	40	3	d81e78bec5c8a3f3ec9e1447ebab2c5805b815eb
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDFY4 ADCY7 IQGAP1	3.75e-04	157	40	3	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC88A WDFY4 HLA-DRB1	3.75e-04	157	40	3	e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CCDC88A WDFY4 HLA-DRB1	3.82e-04	158	40	3	e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-1\|TCGA-Kidney / Sample_Type by Project: Shred V9	UBA5 REN ZNF395	4.03e-04	161	40	3	6cacae4a759ace763597ee394cff498dc5d96f74
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A MYCBP2 LYST	4.11e-04	162	40	3	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MGLL LYST IQGAP1	4.11e-04	162	40	3	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-cDC1\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88A WDFY4 HLA-DRB1	4.11e-04	162	40	3	448602d5ff8b5be9614c63540a4d0fe6bdaf23b4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADK WDFY4 HLA-DRB1	4.18e-04	163	40	3	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 HLA-DRB1	4.25e-04	164	40	3	43045879505774ac0d9b7f760557955564f06d00
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGLL SUOX SPTA1	4.25e-04	164	40	3	f3772227f5aa75a3672d945f8d5bf3fa0b4e456b
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC88A MYCBP2 WDFY4	4.33e-04	165	40	3	1dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCell	NS-control-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MED12L CCDC88A WDFY4	4.33e-04	165	40	3	8b2d43d7c4ee07bd999bd51bc15117ce1fbb2d86
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MED12L ARFGEF3 ADCY7	4.33e-04	165	40	3	f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCDC88A WDFY4 HLA-DRB1	4.33e-04	165	40	3	d8b0a9b6f704b98e8f0412c11739879a26c036e2
ToppCell	control-Myeloid-pDC\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MED12L CCDC88A WDFY4	4.33e-04	165	40	3	243c74adf8d993ff92acbff2768bdc5a1693eca3
ToppCell	LPS-antiTNF-Epithelial_airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 CLCA1 ADCY2	4.41e-04	166	40	3	eb942ed68677e55c46cb039046f45686d4062d7c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 HLA-DRB1	4.41e-04	166	40	3	63dc58864268b4e7779e4c45155022556fc634f9
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	POLR3B ARID1A MGA	4.41e-04	166	40	3	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88A WDFY4 HLA-DRB1	4.41e-04	166	40	3	479391aa6c09aa070b716128ab51b8fec0aea22d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 CLCA1 ADCY2	4.41e-04	166	40	3	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 CLCA1 ADCY2	4.41e-04	166	40	3	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-cDC2\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SUOX SACS HLA-DRB1	4.49e-04	167	40	3	1bd0aa7a3c8649f342bb856cf861c4c5984ad889
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	MED12L MGLL WDFY4	4.49e-04	167	40	3	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCA1 SUOX SPTA1	4.72e-04	170	40	3	37c647f67505aa1ff12a198df1eeddd9f406fe15
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCA1 SUOX SPTA1	4.72e-04	170	40	3	b180ec9a1b79025a180c8559c27c31272410dea8
ToppCell	3'_v3-blood-Hematopoietic_progenitors-HSC-MPP\|blood / Manually curated celltypes from each tissue	MED12L MGLL REN	4.72e-04	170	40	3	1443d7fccc81088dd42dcbb9361e269872542274
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FH SACS WDFY4	4.72e-04	170	40	3	32917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCell	Influenza_Severe-B_intermediate\|World / Disease group and Cell class	MED12L ADK WDFY4	4.81e-04	171	40	3	4d33e1dc1efc423dbdd5f4cca6d6440a68add8d0
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88A WDFY4 HLA-DRB1	4.81e-04	171	40	3	c2b7bbabc8f9afa8a1157b567d5f962d4b242919
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	CCDC88A WDFY4 HLA-DRB1	4.81e-04	171	40	3	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MED12L CCDC88A WDFY4	4.81e-04	171	40	3	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	CCDC88A WDFY4 HLA-DRB1	4.81e-04	171	40	3	debbb071d260639b16269c94d172766908325c58
ToppCell	droplet-Marrow-nan-3m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A MYCBP2 LYST	4.81e-04	171	40	3	992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB10 ADK HLA-DRB1	4.89e-04	172	40	3	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MED12L CLCA1 SPTA1	4.89e-04	172	40	3	e39ea2f4edbf36ebf9604fa6f9349081859c596c
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A MYCBP2 IQGAP1	4.89e-04	172	40	3	3f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MED12L CLCA1 SPTA1	4.89e-04	172	40	3	bcc50bed47465daa953ba91f17d1ee4c947ab461
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A WDFY4 ZMIZ2	4.89e-04	172	40	3	cabe7b4131d72da87d3caacd8cced3a4f2cbef53
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MED12L CLCA1 SPTA1	4.89e-04	172	40	3	875ea290840e835952623b905eb610f3c71456d2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88A WDFY4 ADCY7	4.89e-04	172	40	3	f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_atypical-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ADK WDFY4 HLA-DRB1	4.97e-04	173	40	3	23248019c819f6e38337dcc4edb763ef1992e89e
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88A WDFY4 HLA-DRB1	4.97e-04	173	40	3	d13ae4046a25ee0fb492ddedf44583a879a432e9
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC88A FH HLA-DRB1	4.97e-04	173	40	3	9c7386bf0a899882c733f0b4921a96afde032a7d
Drug	racemic timolol	ADCY4 REN ADCY2 ADCY7 HLA-DRB1	2.86e-08	51	40	5	CID000005478
Drug	NSC759576	ADK ADCY4 REN SACS ADCY2 ADCY7 IQGAP1	3.86e-08	191	40	7	CID000003075
Drug	etorphine	ADCY4 LYST ADCY2 ADCY7 SPTA1	6.03e-08	59	40	5	CID000026721
Drug	PD 81,723	ADK ADCY4 ADCY2 ADCY7	1.01e-07	25	40	4	CID000122028
Drug	prenalterol	ADCY4 REN ADCY2 ADCY7	1.62e-07	28	40	4	CID000042396
Drug	AC1N2DGT	ADCY4 REN ADCY2 ADCY7	2.17e-07	30	40	4	CID004045015
Drug	chlorthalidone	ADCY4 REN ADCY2 ADCY7	4.62e-07	36	40	4	CID000002732
Drug	practolol	ADCY4 REN ADCY2 ADCY7	5.17e-07	37	40	4	CID000004883
Drug	2',5'-dd3'-FSBA	ADCY4 ADCY2 ADCY7	5.98e-07	10	40	3	CID003081206
Drug	NC-5Z	ADCY4 ADCY2 ADCY7	5.98e-07	10	40	3	CID003035914
Drug	N6-cyclohexyladenosine	ADK ADCY4 REN ADCY7	7.13e-07	40	40	4	CID000002692
Drug	AC1NY9KD	ADCY4 ADCY2 ADCY7	8.21e-07	11	40	3	CID005771741
Drug	AC1L40QM	ADCY4 ADCY2 ADCY7	8.21e-07	11	40	3	CID000099213
Drug	B-Mlvp	ADCY4 ADCY2 ADCY7	8.21e-07	11	40	3	CID000195648
Drug	endrine	RAD51D ADCY4 CLCA1 ADCY2 ADCY7	1.15e-06	106	40	5	CID000003048
Drug	AC1L1E8W	ADK ADCY4 REN ADCY2 ADCY7	1.20e-06	107	40	5	CID000002691
Drug	tungstate	ADCY4 FH SUOX ADCY2 ADCY7	1.26e-06	108	40	5	CID000001152
Drug	FCE 23884	ADCY4 ADCY2 ADCY7	1.42e-06	13	40	3	CID000065898
Drug	betaxolol	ADCY4 REN ADCY2 ADCY7	1.50e-06	48	40	4	CID000002369
Drug	xanthine	ADK ADCY4 SUOX ADCY2 ADCY7	2.04e-06	119	40	5	CID000001188
Drug	indapamide	ADCY4 REN ADCY2 ADCY7	2.25e-06	53	40	4	CID000003702
Drug	BMY 42393	ADCY4 ADCY2 ADCY7	2.25e-06	15	40	3	CID000131961
Drug	saccharin	FLII ADCY4 ADCY2 ADCY7	2.42e-06	54	40	4	CID000005143
Drug	2-deoxyadenosine	ADK MGLL ADCY4 ADCY2 ADCY7	3.52e-06	133	40	5	CID000000636
Drug	AC1Q3G0K	RAD51D ADCY4 ADCY2 ADCY7	3.71e-06	60	40	4	CID000002087
Drug	otenzepad	ADCY4 CCDC88A ADCY2 ADCY7	3.96e-06	61	40	4	CID000107867
Drug	naphthalene-diisocyanate	ADCY4 REN ADCY2 ADCY7	4.23e-06	62	40	4	CID003033874
Drug	Ro 41-9067	ADCY4 ADCY2 ADCY7	4.77e-06	19	40	3	CID000125800
Drug	SK&F 82958	ADCY4 ADCY2 ADCY7	4.77e-06	19	40	3	ctd:C071262
Drug	alprenolol	ADCY4 REN ADCY2 ADCY7	4.81e-06	64	40	4	CID000002119
Drug	MDL-12330A	ADCY4 CLCA1 ADCY2 ADCY7	5.44e-06	66	40	4	CID000004024
Drug	reproterol	ADCY4 ADCY2 ADCY7	6.54e-06	21	40	3	CID000025654
Drug	fenoldopam	ADCY4 REN ADCY2 ADCY7	6.89e-06	70	40	4	CID000003340
Drug	4-isopropylaniline	ADCY4 REN ADCY2 ADCY7	7.29e-06	71	40	4	CID000007464
Drug	naltrexone HCl	FLII ADCY4 ADCY2 ADCY7	7.29e-06	71	40	4	CID000004428
Drug	furosemide	SLC6A5 ADCY4 REN CLCA1 ADCY2 ADCY7	7.51e-06	272	40	6	CID000003440
Drug	GSK835726	ADCY4 ADCY2 ADCY7	7.56e-06	22	40	3	CID005311268
Drug	CaCl2	MGLL ADCY4 REN ADCY2 ADCY7	7.68e-06	156	40	5	CID000024854
Drug	beta-CNA	ADCY4 ADCY2 ADCY7	8.68e-06	23	40	3	CID005486190
Drug	Scpb	ADCY4 ADCY2 ADCY7	8.68e-06	23	40	3	CID000123843
Drug	calmidazolium chloride	ADCY4 REN CLCA1 ADCY2 ADCY7	8.68e-06	160	40	5	CID000002531
Drug	NAIN	ADCY4 ADCY2 ADCY7	9.91e-06	24	40	3	CID000195228
Drug	TL-99	ADCY4 ADCY2 ADCY7	9.91e-06	24	40	3	CID000122132
Drug	trimetoquinol	ADCY4 ADCY2 ADCY7	9.91e-06	24	40	3	CID000005581
Drug	AC1L8VEV	ADCY4 ADCY2 ADCY7	9.91e-06	24	40	3	CID000433433
Drug	AC1L2A3V	FLII ADCY4 ADCY2 ADCY7	1.01e-05	77	40	4	CID000068615
Drug	AC1L1H5B	ADCY4 ARID1A ADCY2 ADCY7	1.01e-05	77	40	4	CID000003981
Drug	octimibate	ADCY4 ADCY2 ADCY7	1.12e-05	25	40	3	CID000065676
Drug	manganese-ATP	ADK ADCY4 ADCY7	1.12e-05	25	40	3	CID000124341
Drug	buspirone	ADCY4 REN ADCY2 ADCY7	1.17e-05	80	40	4	CID000002477
Drug	terbutaline	MGLL ADCY4 ADCY2 ADCY7	1.17e-05	80	40	4	CID000005403
Drug	sumatriptan	ADCY4 CCDC88A ADCY2 ADCY7	1.17e-05	80	40	4	CID000005358
Drug	metaproterenol	ADCY4 ADCY2 ADCY7	1.27e-05	26	40	3	CID000004086
Drug	2',3'-dideoxyadenosine	ADK ADCY4 ADCY2 ADCY7	1.29e-05	82	40	4	CID000020039
Drug	SM-10906	ADCY4 ADCY2 ADCY7	1.43e-05	27	40	3	CID006442261
Drug	tetrahydrofurfuryl alcohol	ADCY4 ADCY2 ADCY7	1.60e-05	28	40	3	CID000007360
Drug	desacetylnantradol	ADCY4 ADCY2 ADCY7	1.60e-05	28	40	3	CID000125211
Drug	Nocloprostum	ADCY4 ADCY2 ADCY7	1.60e-05	28	40	3	CID006435380
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	ZBTB10 POLR3B URB2 ARID1A MGA	1.71e-05	184	40	5	2321_DN
Drug	tolazoline	ADCY4 ADCY2 ADCY7	1.78e-05	29	40	3	CID000005504
Drug	dihydroalprenolol	ADCY4 ARID1A ADCY7	1.97e-05	30	40	3	CID000043216
Drug	bicarbonate	ADCY4 REN CLCA1 SACS ADCY2 ADCY7	2.06e-05	325	40	6	CID000000767
Drug	tienilic acid	ADCY4 REN ADCY2 ADCY7	2.13e-05	93	40	4	CID000038409
Drug	pirenzepine	ADCY4 CCDC88A ADCY2 ADCY7	2.13e-05	93	40	4	CID000004848
Drug	dopexamine	ADCY4 ADCY2 ADCY7	2.41e-05	32	40	3	CID000055483
Drug	ADP beta S	ADCY4 REN ADCY2 ADCY7	2.41e-05	96	40	4	CID005310996
Drug	levo-dromoran tartrate	MGLL ADCY4 ADCY2 ADCY7	2.62e-05	98	40	4	CID000003918
Drug	6,7-ADTN	ADCY4 ADCY2 ADCY7	2.64e-05	33	40	3	CID000003153
Drug	phosphonate analog	ADCY4 ADCY2 ADCY7	2.64e-05	33	40	3	CID000475766
Drug	vanadium pentoxide	ADCY4 LYST ADCY2 ADCY7	2.84e-05	100	40	4	ctd:C066075
Drug	2-chloroadenosine	ADK ADCY4 ADCY2 ADCY7	3.07e-05	102	40	4	CID000008974
Drug	phosphoenolpyruvate	ADCY4 FH SACS ADCY2 ADCY7	3.22e-05	210	40	5	CID000001005
Drug	AC1L1DSZ	ADCY4 ADCY2 ADCY7	3.45e-05	36	40	3	CID000002494
Drug	oxotremorine	ADCY4 CLCA1 ADCY2 ADCY7	3.84e-05	108	40	4	CID000004630
Drug	2g6p	ADCY4 ADCY2 ADCY7	4.06e-05	38	40	3	CID002740174
Drug	AC1L1XPX	ADCY4 ADCY2 ADCY7	4.06e-05	38	40	3	CID000011606
Drug	serotonin	SLC6A5 ADCY4 REN POLR3B CLCA1 ADCY2 ADCY7	4.52e-05	554	40	7	CID000005202
Drug	N-arachidonoylethanolamine	SLC6A5 MGLL ADCY4 ADCY2 ADCY7	4.57e-05	226	40	5	CID000002185
Drug	dimaprit	ADCY4 ADCY2 ADCY7	4.74e-05	40	40	3	CID000003077
Drug	phenoxybenzamine	ADCY4 REN ADCY2 ADCY7	4.91e-05	115	40	4	CID000004768
Drug	potassium	SLC6A5 ADK ADCY4 REN CLCA1 SACS ADCY2 ADCY7 SPTA1	4.99e-05	1008	40	9	CID000000813
Drug	AC1NIP3C	ADCY4 ADCY2 ADCY7	5.11e-05	41	40	3	CID004834553
Drug	AC1L1I54	ADCY4 ADCY2 ADCY7	5.11e-05	41	40	3	CID000004426
Drug	AC1MPJID	ADCY4 ADCY2 ADCY7 HLA-DRB1	5.25e-05	117	40	4	CID003386230
Drug	hydrochlorothiazide	ADCY4 REN ADCY2 ADCY7	5.79e-05	120	40	4	CID000003639
Drug	haloperidol	FLII ADCY4 REN ZNF395 ADCY2 ADCY7	6.03e-05	394	40	6	CID000003559
Drug	atenolol	ADCY4 REN ADCY2 ADCY7	6.18e-05	122	40	4	CID000002249
Drug	theophylline	ADK ADCY4 REN ADCY2 ADCY7	6.20e-05	241	40	5	CID000002153
Drug	benzeneacetamide	ADCY4 ADCY2 ADCY7	7.24e-05	46	40	3	CID000007680
Drug	picryl chloride	CCDC88A SACS LYST	7.24e-05	46	40	3	CID000006953
Drug	prostacyclin sodium salt	ADCY4 REN ADCY2 ADCY7 IQGAP1	7.37e-05	250	40	5	CID000000159
Drug	Lypressin	ADCY4 REN ADCY7	7.72e-05	47	40	3	CID000005772
Drug	ketanserin	ADCY4 REN ADCY2 ADCY7	8.15e-05	131	40	4	CID000003822
Drug	procaterol	ADCY4 ADCY2 ADCY7	8.22e-05	48	40	3	CID000004916
Drug	Neomigran	ADCY4 ADCY2 ADCY7	8.22e-05	48	40	3	CID000003066
Drug	AC1L1EV8	ADCY4 ADCY7	8.37e-05	8	40	2	CID000002964
Drug	UTP-NA	ADK ADCY4 POLR3B CLCA1 ADCY2 ADCY7	8.58e-05	420	40	6	CID000001181
Drug	tetrathionate	REN SUOX SPTA1	8.75e-05	49	40	3	CID000026259
Drug	Gastrin tetrapeptide	ADCY4 ADCY2 ADCY7	9.30e-05	50	40	3	CID000005415
Drug	AC1L1FA8	ADCY4 ADCY2 ADCY7	9.30e-05	50	40	3	CID000003150
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY4 LYST	1.02e-05	4	39	2	DOID:2935 (implicated_via_orthology)
Disease	bilirubin measurement	MYDGF MGLL ARID1A GLI2 HLA-DRB1 SPTA1	2.34e-05	442	39	6	EFO_0004570
Disease	anti-Epstein Barr virus antibody measurement	MED12L HLA-DRB1	1.11e-04	12	39	2	EFO_0009273
Disease	platelet-to-lymphocyte ratio	MED12L MYDGF HLA-DRB1 SPTA1 IQGAP1	1.12e-04	363	39	5	EFO_0008446
Disease	T-Cell Lymphoma	ARID1A MGA	2.02e-04	16	39	2	C0079772
Disease	toxic shock syndrome (is_marker_for)	REN HLA-DRB1	2.87e-04	19	39	2	DOID:14115 (is_marker_for)
Disease	Intellectual Disability	MED12L ADK UBA5 POLR3B SACS	2.94e-04	447	39	5	C3714756
Disease	ulcerative colitis, Crohn's disease	ADCY7 HLA-DRB1	3.19e-04	20	39	2	EFO_0000384, EFO_0000729
Disease	Parkinson disease	MED12L POLR3B MYCBP2 HLA-DRB1	8.37e-04	321	39	4	MONDO_0005180
Disease	response to cytosine arabinoside	SLC6A5 URB2	9.85e-04	35	39	2	EFO_0005655

Protein segments in the cluster

Peptide	Gene	Start	Entry
NQRTTASWDGQVGMV	URB2	716	Q14146
GSTQNSIKVAQWMIQ	ADK	81	P55263
VVMVTQQSSDGWLEG	ARHGEF5	1536	Q12774
IWGNTVNVASRMEST	ADCY4	1006	Q8NFM4
IWGNTVNVASRMEST	ADCY7	1011	P51828
KSWVNQMESQTGEAS	IQGAP1	1096	P46940
QEMVDIGTWGTSEQS	RAD51D	306	O75771
QASAEVAQQGTMWQG	ARID1A	1486	O14497
QAVGGMVTTTTDWNQ	KIAA0100	1676	Q14667
GQEVYMWVGTQTSQV	FLII	1201	Q13045
VGGMFDTVQRSTQWT	MED12L	1526	Q86YW9
TVGGITVTLDNNSMW	MGA	71	Q8IWI9
INMWVSQRTATAGTA	MGLL	286	Q99685
WQVNRGNMVAQSSDV	MMS19	581	Q96T76
VQSMVLAGQWTGSTE	CCDC88A	1496	Q3V6T2
NMPVQWNEVSSGTVD	GLI2	1141	P10070
WGNTVNVASRMDSTG	ADCY2	1021	Q08462
QQSVMGYQVWSSAVV	COG1	676	Q8WTW3
WQTGSGTQTNMNVNE	FH	141	P07954
QVQTSGVLMVFSQAW	ARFGEF3	771	Q5TH69
VSIWAMVTSVDGSQQ	CPAMD8	316	Q8IZJ3
MVSTGLIQNGDWTFQ	HLA-DRB1	171	P01911
QGVRSMNSTDIQWSA	LYST	3521	Q99698
NGVGVRSDWNNSLMT	SACS	2901	Q9NZJ4
WVNMSQSTVVLATDG	SLC6A5	151	Q9Y345
VWQIQMKGVSVGSST	REN	266	P00797
GVVVVVNFNSVGSWM	MT-ND6	111	P03923
TSQIGMSQPGTWQTG	SATL1	406	Q86VE3
NSEGTWVQLDQNSMV	MYCBP2	2631	O75592
NAVSEGLSGWSQSVM	ANKHD1	2406	Q8IWZ3
LQNSQWMNGTVIVDS	CLCA1	496	A8K7I4
NELGQTWMESGVSEN	UBA5	196	Q9GZZ9
WDTSQIIITGSQDGM	WDFY4	3081	Q6ZS81
TGLVEQHSWMEGQVT	ZNF395	91	Q9H8N7
ITNGMVNAISTGNWS	POLR3B	411	Q9NW08
LQNWISSIGGMVSSQ	SPTA1	1301	P02549
VVTTVWGVGNATQSQ	ZMIZ2	41	Q8NF64
SGDNSSTQGWRVMGT	SUOX	46	P51687
SEGQTKVFIWNNMGS	ZBTB10	551	Q96DT7
WMSGVEQQVASLSGQ	SUN1	361	O94901
IQNTGSQWEVMESSK	ZNF529	96	Q6P280
GGTNEQWQMSLGTSE	MYDGF	71	Q969H8