Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprolactin receptor binding

GH1 GH2 CSH1 CSH2

1.66e-097544GO:0005148
GeneOntologyMolecularFunctiongrowth hormone receptor binding

GH1 GH2 CSH1 CSH2

9.91e-0910544GO:0005131
GeneOntologyMolecularFunctionhormone receptor binding

GH1 GH2 CSH1 CSH2

2.09e-0634544GO:0051427
GeneOntologyMolecularFunctionhormone activity

GH1 GH2 CSH1 CSH2 INSL4

3.18e-05135545GO:0005179
GeneOntologyMolecularFunctionpeptide antigen binding

SLC7A8 HLA-E TAP1

3.15e-0449543GO:0042605
GeneOntologyMolecularFunctionTAP1 binding

HLA-E TAP1

3.19e-0410542GO:0046978
GeneOntologyMolecularFunctionTAP2 binding

HLA-E TAP1

3.19e-0410542GO:0046979
GeneOntologyMolecularFunctionTAP binding

HLA-E TAP1

3.19e-0410542GO:0046977
GeneOntologyMolecularFunctiongrowth factor activity

GH1 GH2 CSH1 CSH2

1.23e-03173544GO:0008083
GeneOntologyBiologicalProcesspositive regulation of steroid hormone biosynthetic process

GH1 GH2 CSH1 CSH2

2.73e-0813534GO:0090031
GeneOntologyBiologicalProcessregulation of response to nutrient levels

GH1 GH2 CSH1 CSH2 MTOR

1.17e-0746535GO:0032107
GeneOntologyBiologicalProcesspositive regulation of hormone biosynthetic process

GH1 GH2 CSH1 CSH2

1.46e-0719534GO:0046886
GeneOntologyBiologicalProcessresponse to food

GH1 GH2 CSH1 CSH2 MTOR

3.82e-0758535GO:0032094
GeneOntologyBiologicalProcessregulation of steroid hormone biosynthetic process

GH1 GH2 CSH1 CSH2

3.97e-0724534GO:0090030
GeneOntologyBiologicalProcessgrowth hormone receptor signaling pathway

GH1 GH2 CSH1 CSH2

5.57e-0726534GO:0060396
GeneOntologyBiologicalProcesspositive regulation of hormone metabolic process

GH1 GH2 CSH1 CSH2

5.57e-0726534GO:0032352
GeneOntologyBiologicalProcesscellular response to growth hormone stimulus

GH1 GH2 CSH1 CSH2

6.52e-0727534GO:0071378
GeneOntologyBiologicalProcessregulation of hormone biosynthetic process

GH1 GH2 CSH1 CSH2

2.15e-0636534GO:0046885
GeneOntologyBiologicalProcesspositive regulation of steroid biosynthetic process

GH1 GH2 CSH1 CSH2

2.69e-0638534GO:0010893
GeneOntologyBiologicalProcessresponse to growth hormone

GH1 GH2 CSH1 CSH2

3.67e-0641534GO:0060416
GeneOntologyBiologicalProcesspositive regulation of steroid metabolic process

GH1 GH2 CSH1 CSH2

4.04e-0642534GO:0045940
GeneOntologyBiologicalProcesspositive regulation of multicellular organism growth

GH1 GH2 CSH1 CSH2

6.38e-0647534GO:0040018
GeneOntologyBiologicalProcesspositive regulation of lipid biosynthetic process

GH1 GH2 CSH1 CSH2 MTOR

1.46e-05121535GO:0046889
GeneOntologyBiologicalProcesspositive regulation of receptor signaling pathway via JAK-STAT

GH1 GH2 CSH1 CSH2

1.49e-0558534GO:0046427
GeneOntologyBiologicalProcessregulation of hormone metabolic process

GH1 GH2 CSH1 CSH2

1.49e-0558534GO:0032350
GeneOntologyBiologicalProcesspositive regulation of D-glucose transmembrane transport

GH1 GH2 CSH1 CSH2

2.07e-0563534GO:0010828
GeneOntologyBiologicalProcesspositive regulation of receptor signaling pathway via STAT

GH1 GH2 CSH1 CSH2

2.34e-0565534GO:1904894
GeneOntologyBiologicalProcesspositive regulation of tyrosine phosphorylation of STAT protein

GH1 GH2 CSH1 CSH2

2.97e-0569534GO:0042531
GeneOntologyBiologicalProcesscardiac left ventricle formation

PCDHA12 PCDHA10

3.87e-054532GO:0003218
GeneOntologyBiologicalProcesslung alveolus development

GH1 GH2 CSH1 CSH2

4.13e-0575534GO:0048286
GeneOntologyBiologicalProcessmulticellular organism growth

GH1 GH2 CSH1 CSH2 MTOR HLA-E

4.16e-05249536GO:0035264
GeneOntologyBiologicalProcesshormone biosynthetic process

GH1 GH2 CSH1 CSH2

6.14e-0583534GO:0042446
GeneOntologyBiologicalProcesspositive regulation of lipid metabolic process

GH1 GH2 CSH1 CSH2 MTOR

6.49e-05165535GO:0045834
GeneOntologyBiologicalProcessregulation of tyrosine phosphorylation of STAT protein

GH1 GH2 CSH1 CSH2

6.74e-0585534GO:0042509
GeneOntologyBiologicalProcessregulation of intracellular steroid hormone receptor signaling pathway

GH1 GH2 CSH1 CSH2

7.38e-0587534GO:0033143
GeneOntologyBiologicalProcesstyrosine phosphorylation of STAT protein

GH1 GH2 CSH1 CSH2

8.43e-0590534GO:0007260
GeneOntologyBiologicalProcesshormone metabolic process

GH1 GH2 CSH1 CSH2 CYP2S1 GCNT4

8.96e-05286536GO:0042445
GeneOntologyBiologicalProcessregulation of multicellular organism growth

GH1 GH2 CSH1 CSH2

9.58e-0593534GO:0040014
GeneOntologyBiologicalProcesspositive regulation of peptidyl-tyrosine phosphorylation

GH1 GH2 CSH1 CSH2 MTOR

1.36e-04193535GO:0050731
GeneOntologyBiologicalProcessneuroblast proliferation

GH1 GH2 CSH1 CSH2

1.48e-04104534GO:0007405
GeneOntologyBiologicalProcessregulation of D-glucose transmembrane transport

GH1 GH2 CSH1 CSH2

1.53e-04105534GO:0010827
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

GH1 GH2 CSH1 CSH2

1.59e-04106534GO:0050810
GeneOntologyBiologicalProcessrRNA transcription

POLR1A MTOR TAF1B

2.25e-0446533GO:0009303
GeneOntologyBiologicalProcessprotection from natural killer cell mediated cytotoxicity

HLA-E TAP1

2.31e-049532GO:0042270
GeneOntologyBiologicalProcessresponse to radiation

GH1 GH2 CSH1 CSH2 MTOR SPIDR CNGB1

2.87e-04503537GO:0009314
GeneOntologyBiologicalProcesscardiac ventricle formation

PCDHA12 PCDHA10

2.88e-0410532GO:0003211
GeneOntologyBiologicalProcessregulation of receptor signaling pathway via JAK-STAT

GH1 GH2 CSH1 CSH2

2.99e-04125534GO:0046425
GeneOntologyBiologicalProcessregulation of hormone levels

GH1 GH2 SLC7A8 CSH1 CSH2 CYP2S1 GCNT4 BAIAP3

3.33e-04684538GO:0010817
GeneOntologyBiologicalProcesspositive regulation of developmental growth

GH1 GH2 CSH1 CSH2 MTOR

3.58e-04238535GO:0048639
GeneOntologyBiologicalProcessregulation of steroid metabolic process

GH1 GH2 CSH1 CSH2

4.01e-04135534GO:0019218
GeneOntologyBiologicalProcessnuclear receptor-mediated steroid hormone signaling pathway

GH1 GH2 CSH1 CSH2

4.12e-04136534GO:0030518
GeneOntologyBiologicalProcessregulation of lipid biosynthetic process

GH1 GH2 CSH1 CSH2 MTOR

4.17e-04246535GO:0046890
GeneOntologyBiologicalProcesscellular response to peptide hormone stimulus

GH1 GH2 CSH1 CSH2 MTOR GNRHR2

4.21e-04381536GO:0071375
GeneOntologyBiologicalProcessresponse to light stimulus

GH1 GH2 CSH1 CSH2 MTOR CNGB1

4.27e-04382536GO:0009416
GeneOntologyBiologicalProcessregulation of receptor signaling pathway via STAT

GH1 GH2 CSH1 CSH2

4.98e-04143534GO:1904892
GeneOntologyBiologicalProcessD-glucose transmembrane transport

GH1 GH2 CSH1 CSH2

5.67e-04148534GO:1904659
GeneOntologyBiologicalProcesscardiac chamber formation

PCDHA12 PCDHA10

5.78e-0414532GO:0003207
GeneOntologyBiologicalProcesshexose transmembrane transport

GH1 GH2 CSH1 CSH2

6.12e-04151534GO:0008645
GeneOntologyBiologicalProcesscellular response to insulin stimulus

GH1 GH2 CSH1 CSH2 MTOR

6.47e-04271535GO:0032869
GeneOntologyBiologicalProcessregulation of peptidyl-tyrosine phosphorylation

GH1 GH2 CSH1 CSH2 MTOR

6.58e-04272535GO:0050730
GeneOntologyBiologicalProcessmonosaccharide transmembrane transport

GH1 GH2 CSH1 CSH2

6.58e-04154534GO:0015749
GeneOntologyBiologicalProcesspositive regulation of transmembrane transport

GH1 GH2 THY1 CSH1 CSH2

6.69e-04273535GO:0034764
GeneOntologyBiologicalProcesssteroid hormone receptor signaling pathway

GH1 GH2 CSH1 CSH2

6.75e-04155534GO:0043401
GeneOntologyBiologicalProcessphotoreceptor cell development

THY1 MFRP CNGB1

8.78e-0473533GO:0042461
GeneOntologyBiologicalProcesscarbohydrate transmembrane transport

GH1 GH2 CSH1 CSH2

9.11e-04168534GO:0034219
GeneOntologyBiologicalProcessheart valve development

MTOR PCDHA12 PCDHA10

1.06e-0378533GO:0003170
GeneOntologyBiologicalProcesstranscription by RNA polymerase I

POLR1A MTOR TAF1B

1.10e-0379533GO:0006360
GeneOntologyBiologicalProcesscarbohydrate transport

GH1 GH2 CSH1 CSH2

1.33e-03186534GO:0008643
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

PCDHA12 PCDHA10 PCDHA8 PCDHA4

1.35e-03187534GO:0007156
GeneOntologyBiologicalProcesspeptidyl-tyrosine phosphorylation

GH1 GH2 CSH1 CSH2 MTOR

1.49e-03327535GO:0018108
GeneOntologyBiologicalProcesspeptidyl-tyrosine modification

GH1 GH2 CSH1 CSH2 MTOR

1.54e-03329535GO:0018212
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class I

HLA-E TAP1

1.58e-0323532GO:0019885
GeneOntologyBiologicalProcesscell surface receptor signaling pathway via JAK-STAT

GH1 GH2 CSH1 CSH2

1.67e-03198534GO:0007259
GeneOntologyBiologicalProcesspositive regulation of growth

GH1 GH2 CSH1 CSH2 MTOR

1.75e-03339535GO:0045927
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

GH1 GH2 CSH1 CSH2

1.80e-03202534GO:0141193
GeneOntologyBiologicalProcessresponse to insulin

GH1 GH2 CSH1 CSH2 MTOR

1.82e-03342535GO:0032868
GeneOntologyBiologicalProcesscardiac left ventricle morphogenesis

PCDHA12 PCDHA10

1.87e-0325532GO:0003214
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen

HLA-E TAP1

1.87e-0325532GO:0002483
GeneOntologyBiologicalProcessphotoreceptor cell differentiation

THY1 MFRP CNGB1

1.93e-0396533GO:0046530
GeneOntologyBiologicalProcessregulation of neurogenesis

GH1 GH2 THY1 CSH1 CSH2 MTOR

2.00e-03515536GO:0050767
GeneOntologyBiologicalProcessnucleolar large rRNA transcription by RNA polymerase I

MTOR TAF1B

2.02e-0326532GO:0042790
GeneOntologyBiologicalProcesssteroid biosynthetic process

GH1 GH2 CSH1 CSH2

2.03e-03209534GO:0006694
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

GH1 GH2 CSH1 CSH2 MTOR

2.11e-03354535GO:0050769
GeneOntologyBiologicalProcessdevelopmental growth

GH1 GH2 SLC39A12 CSH1 CSH2 MTOR INSL4 HLA-E

2.13e-03911538GO:0048589
GeneOntologyBiologicalProcesscell surface receptor signaling pathway via STAT

GH1 GH2 CSH1 CSH2

2.29e-03216534GO:0097696
GeneOntologyBiologicalProcessresponse to peptide hormone

GH1 GH2 CSH1 CSH2 MTOR GNRHR2

2.31e-03530536GO:0043434
GeneOntologyCellularComponentgrowth hormone receptor complex

GH1 GH2 CSH1 CSH2

5.94e-106544GO:0070195
GeneOntologyCellularComponentGolgi apparatus subcompartment

GH1 GH2 CSH1 CSH2 HLA-E GAL3ST3 BIRC6 BAIAP3

1.69e-05443548GO:0098791
GeneOntologyCellularComponenttrans-Golgi network

GH1 GH2 CSH1 CSH2 BIRC6 BAIAP3

1.34e-04306546GO:0005802
GeneOntologyCellularComponentendosome lumen

GH1 GH2 CSH1

1.87e-0443543GO:0031904
GeneOntologyCellularComponentMHC class I peptide loading complex

HLA-E TAP1

5.84e-0414542GO:0042824
GeneOntologyCellularComponentcis-Golgi network membrane

HLA-E PHTF1

8.69e-0417542GO:0033106
MousePhenodecreased pituitary gland weight

GH1 GH2 CSH1 CSH2

4.42e-098414MP:0008938
MousePhenoabsent somatotrophs

GH1 GH2 CSH1 CSH2

7.94e-099414MP:0008330
MousePhenoabsent lactotrophs

GH1 GH2 CSH1 CSH2

7.94e-099414MP:0008333
MousePhenoincreased circulating ghrelin level

GH1 GH2 CSH1 CSH2

3.10e-0812414MP:0011612
MousePhenoabnormal pituitary gland weight

GH1 GH2 CSH1 CSH2

3.10e-0812414MP:0008937
MousePhenoabnormal circulating ghrelin level

GH1 GH2 CSH1 CSH2

8.49e-0815414MP:0011611
MousePhenodecreased lactotroph cell number

GH1 GH2 CSH1 CSH2

1.47e-0717414MP:0008332
MousePhenoabnormal lactotroph morphology

GH1 GH2 CSH1 CSH2

2.39e-0719414MP:0008323
MousePhenodelayed sexual maturation

GH1 GH2 CSH1 CSH2 INSL4

2.92e-0749415MP:0001938
MousePhenodecreased somatotroph cell number

GH1 GH2 CSH1 CSH2

3.68e-0721414MP:0008329
MousePhenosmall adenohypophysis

GH1 GH2 CSH1 CSH2

5.42e-0723414MP:0008321
MousePhenoabnormal somatotroph morphology

GH1 GH2 CSH1 CSH2

6.49e-0724414MP:0008322
MousePhenodelayed vaginal opening

GH1 GH2 CSH1 CSH2

1.24e-0628414MP:0002636
MousePhenosmall pituitary gland

GH1 GH2 CSH1 CSH2

1.65e-0630414MP:0005361
MousePhenoabnormal timing of vaginal opening

GH1 GH2 CSH1 CSH2

1.89e-0631414MP:0020150
MousePhenoabnormal sexual maturation

GH1 GH2 CSH1 CSH2 INSL4

2.34e-0674415MP:0001937
MousePhenoabnormal secondary sex determination

GH1 GH2 CSH1 CSH2 INSL4

6.17e-0690415MP:0002212
MousePhenoabnormal pituitary gland size

GH1 GH2 CSH1 CSH2

6.58e-0642414MP:0008936
MousePhenoincreased brown adipose tissue amount

GH1 GH2 CSH1 CSH2

7.23e-0643414MP:0000005
MousePhenoincreased white adipose tissue amount

GH1 GH2 CSH1 CSH2

1.56e-0552414MP:0000008
MousePhenodisproportionate dwarf

GH1 GH2 CSH1 CSH2

2.25e-0557414MP:0002427
MousePhenodecreased kidney weight

GH1 GH2 CSH1 CSH2

4.02e-0566414MP:0003918
MousePhenoabnormal brown adipose tissue amount

GH1 GH2 CSH1 CSH2

9.44e-0582414MP:0001778
MousePhenoabnormal adenohypophysis morphology

GH1 GH2 CSH1 CSH2

1.48e-0492414MP:0004163
MousePhenodecreased lean body mass

GH1 GH2 CSH1 CSH2 MTOR TMEM161B SPIDR

1.61e-04407417MP:0003961
MousePhenofemale infertility

GH1 EIF4E1B GH2 CSH1 CSH2 SPIDR CCDC180

1.68e-04410417MP:0001926
MousePhenoincreased total body fat amount

GH1 GH2 CSH1 CSH2 MTOR TMEM161B SPIDR

2.07e-04424417MP:0010024
MousePhenodecreased fasting circulating glucose level

GH1 GH2 CSH1 CSH2 MFRP

2.81e-04200415MP:0013278
MousePhenoaorta hypoplasia

PCDHA12 PCDHA10

2.98e-049412MP:0010541
MousePhenodecreased spleen weight

GH1 GH2 CSH1 CSH2

3.26e-04113414MP:0004953
MousePhenodecreased prepulse inhibition

GH1 GH2 SLC7A8 CSH1 CSH2 CTSA XKR5

3.58e-04464417MP:0009142
MousePhenodecreased bone mineral content

GH1 GH2 CSH1 CSH2 TMEM161B RTTN SPIDR

3.63e-04465417MP:0010124
MousePhenodecreased heart weight

GH1 GH2 CSH1 CSH2

3.84e-04118414MP:0002834
MousePhenoabnormal heart size

GH1 GH2 CSH1 CSH2 RTTN HLA-E LRRC10 PCDHA12 PCDHA10 CTSA BIRC6

4.37e-0411804111MP:0005406
MousePhenoabnormal pituitary gland morphology

GH1 GH2 CSH1 CSH2

6.39e-04135414MP:0000633
MousePhenoabnormal white adipose tissue amount

GH1 GH2 CSH1 CSH2

6.94e-04138414MP:0001781
MousePhenoabnormal prepulse inhibition

GH1 GH2 SLC7A8 CSH1 CSH2 CTSA XKR5

9.05e-04542417MP:0003088
MousePhenoabnormal brown adipose tissue morphology

GH1 GH2 CSH1 CSH2

1.10e-03156414MP:0002971
MousePhenoabnormal neuroendocrine gland morphology

GH1 GH2 CSH1 CSH2

1.10e-03156414MP:0000631
MousePhenoaorta stenosis

PCDHA12 PCDHA10

1.11e-0317412MP:0010463
MousePhenothrombocytopenia

GH1 GH2 CSH1 CSH2 CTSA

1.15e-03273415MP:0003179
MousePhenosmall spleen

GH1 GH2 CSH1 CSH2 MTOR EYA2

1.25e-03416416MP:0000692
MousePhenoabnormal lean body mass

GH1 GH2 CSH1 CSH2 MTOR TMEM161B HLA-E SPIDR

1.29e-03749418MP:0003959
MousePhenoabnormal diencephalon morphology

GH1 GH2 CSH1 CSH2 MTOR

1.70e-03298415MP:0000830
MousePhenoabnormal CNS synaptic transmission

GH1 GH2 SLC7A8 THY1 CSH1 CSH2 CTSA BAIAP3 XKR5

1.86e-03985419MP:0002206
MousePhenodecreased skeletal muscle weight

MTOR WFIKKN2

2.22e-0324412MP:0010239
MousePhenosmall heart

GH1 GH2 CSH1 CSH2 RTTN

2.35e-03321415MP:0002188
MousePhenobicuspid aortic valve

PCDHA12 PCDHA10

2.41e-0325412MP:0010484
MousePhenoabnormal fasting circulating glucose level

GH1 GH2 CSH1 CSH2 MFRP XKR5

2.42e-03474416MP:0013277
DomainSOMATOTROPIN_2

GH1 GH2 CSH1 CSH2

7.98e-106524PS00338
DomainSOMATOTROPIN_1

GH1 GH2 CSH1 CSH2

7.98e-106524PS00266
DomainHormone_1

GH1 GH2 CSH1 CSH2

7.98e-106524PF00103
DomainSomatotropin

GH1 GH2 CSH1 CSH2

1.86e-097524IPR001400
DomainSomatotropin_CS

GH1 GH2 CSH1

2.03e-075523IPR018116
DomainCadherin_tail

PCDHA12 PCDHA10 PCDHA8 PCDHA4

3.30e-0637524PF15974
DomainCadherin_CBD

PCDHA12 PCDHA10 PCDHA8 PCDHA4

3.30e-0637524IPR031904
Domain4_helix_cytokine_core

GH1 GH2 CSH1 CSH2

1.21e-0551524IPR012351
DomainCadherin_N

PCDHA12 PCDHA10 PCDHA8 PCDHA4

3.19e-0565524IPR013164
DomainCadherin_2

PCDHA12 PCDHA10 PCDHA8 PCDHA4

3.19e-0565524PF08266
Domain4_helix_cytokine-like_core

GH1 GH2 CSH1 CSH2

5.32e-0574524IPR009079
DomainCadherin_CS

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.40e-04109524IPR020894
DomainCadherin

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.75e-04113524PF00028
DomainCADHERIN_1

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.75e-04113524PS00232
DomainCADHERIN_2

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.84e-04114524PS50268
Domain-

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.84e-041145242.60.40.60
DomainCA

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.94e-04115524SM00112
DomainCadherin-like

PCDHA12 PCDHA10 PCDHA8 PCDHA4

3.04e-04116524IPR015919
DomainCadherin

PCDHA12 PCDHA10 PCDHA8 PCDHA4

3.24e-04118524IPR002126
Domain-

GH1 GH2 CSH1

3.64e-04505231.20.1250.10
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

GH1 GH2 CSH1 CSH2

1.99e-0813344MM14516
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

GH1 GH2 CSH1 CSH2

5.03e-0816344MM15710
PathwayBIOCARTA_LONGEVITY_PATHWAY

GH1 GH2 CSH1 CSH2

1.07e-0719344MM1513
PathwayREACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN

GH1 GH2 CSH1 CSH2

1.33e-0720344MM15070
PathwayBIOCARTA_AKT_PATHWAY

GH1 GH2 CSH1 CSH2

4.06e-0726344MM1345
PathwayBIOCARTA_TFF_PATHWAY

GH1 GH2 CSH1 CSH2

6.42e-0729344MM1522
PathwayBIOCARTA_GH_PATHWAY

GH1 GH2 CSH1 CSH2

1.10e-0633344MM1404
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

GH1 GH2 CSH1

5.72e-0615343M552
PathwayWP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY

GH1 EIF4E1B GH2 COL4A6 CSH1 CSH2 MTOR

1.04e-05326347MM15917
PathwayWP_PI3KAKT_SIGNALING

GH1 EIF4E1B GH2 COL4A6 CSH1 CSH2 MTOR

1.34e-05339347M39736
PathwayREACTOME_PEPTIDE_HORMONE_METABOLISM

GH1 GH2 CSH1 CSH2

2.31e-0570344MM14916
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

GH1 GH2 CSH1

2.51e-0524343M519
PathwayKEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY

GH1 GH2 ADCY4

4.03e-0528343M47647
PathwayKEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY

GH1 GH2

1.18e-047342M47646
PathwayWP_ADIPOGENESIS_GENES

GH1 GH2 CSH1 CSH2

3.16e-04137344MM15970
PathwayKEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES

HLA-E TAP1

3.67e-0412342M47529
PathwayKEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY

GH1 GH2

7.51e-0417342M47905
PathwayREACTOME_ER_PHAGOSOME_PATHWAY

HLA-E TAP1

8.43e-0418342MM14525
Pubmed

The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.

GH1 GH2 CSH1 CSH2 MTOR

1.56e-13754517284572
Pubmed

microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling.

GH1 GH2 CSH1 CSH2 MTOR

1.56e-13754536976763
Pubmed

The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.

GH1 GH2 CSH1 CSH2

5.19e-1245447169009
Pubmed

Central growth hormone action regulates metabolism during pregnancy.

GH1 GH2 CSH1 CSH2

2.59e-11554431479305
Pubmed

Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.

GH1 GH2 CSH1 CSH2

2.59e-11554410767558
Pubmed

Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency.

GH1 GH2 CSH1 CSH2

2.59e-1155448496314
Pubmed

Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples.

GH1 GH2 CSH1 CSH2

2.59e-11554421045135
Pubmed

Analysis of gender difference of cardiac risk biomarkers using hGH-transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554416508206
Pubmed

Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference.

GH1 GH2 CSH1 CSH2

2.59e-11554418006625
Pubmed

Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.

GH1 GH2 CSH1 CSH2

2.59e-11554415616010
Pubmed

Nitric oxide stimulates embryonic somatotroph differentiation and growth hormone mRNA and protein expression through a cyclic guanosine monophosphate-independent mechanism.

GH1 GH2 CSH1 CSH2

2.59e-11554419019400
Pubmed

The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?

GH1 GH2 CSH1 CSH2

2.59e-11554432556100
Pubmed

High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice.

GH1 GH2 CSH1 CSH2

2.59e-1155441525063
Pubmed

Obesity and elevated plasma leptin concentration in oMT1A-o growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554411346667
Pubmed

Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554412010633
Pubmed

Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.

GH1 GH2 CSH1 CSH2

2.59e-11554417626886
Pubmed

Growth hormone prevents the development of autoimmune diabetes.

GH1 GH2 CSH1 CSH2

2.59e-11554424218587
Pubmed

Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.

GH1 GH2 CSH1 CSH2

2.59e-11554419359380
Pubmed

Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.

GH1 GH2 CSH1 CSH2

2.59e-1155449546108
Pubmed

Transgene transmission to progeny by oMt1a-oGH transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554416201410
Pubmed

Growth hormone stimulates the selective trafficking of thymic CD4+CD8- emigrants to peripheral lymphoid organs.

GH1 GH2 CSH1 CSH2

2.59e-11554415316240
Pubmed

Genes that prolong life: relationships of growth hormone and growth to aging and life span.

GH1 GH2 CSH1 CSH2

2.59e-11554411487592
Pubmed

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554411318985
Pubmed

Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.

GH1 GH2 CSH1 CSH2

2.59e-11554417301034
Pubmed

Growth hormone action in the developing neural retina: a proteomic analysis.

GH1 GH2 CSH1 CSH2

2.59e-11554418203262
Pubmed

Identification of the glomerular podocyte as a target for growth hormone action.

GH1 GH2 CSH1 CSH2

2.59e-11554417272398
Pubmed

Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis.

GH1 GH2 CSH1 CSH2

2.59e-11554420707609
Pubmed

Assignment of the porcine growth hormone gene to chromosome 12.

GH1 GH2 CSH1 CSH2

2.59e-1155442249485
Pubmed

Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.

GH1 GH2 CSH1 CSH2

2.59e-11554417242167
Pubmed

A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice.

GH1 GH2 CSH1 CSH2

2.59e-11554418180319
Pubmed

Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-1155441874564
Pubmed

Cloning and characterisation of the GH gene from the common dolphin (Delphinus delphis).

GH1 GH2 CSH1 CSH2

2.59e-11554412225773
Pubmed

Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.

GH1 GH2 CSH1 CSH2

2.59e-11554432100023
Pubmed

The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.

GH1 GH2 CSH1 CSH2

2.59e-1155443780533
Pubmed

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554410395045
Pubmed

Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes.

GH1 GH2 CSH1 CSH2

2.59e-11554424190208
Pubmed

Brief report: short stature caused by a mutant growth hormone.

GH1 GH2 CSH1 CSH2

2.59e-1155448552145
Pubmed

Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.

GH1 GH2 CSH1 CSH2

2.59e-11554436762426
Pubmed

High molecular weight isoforms of growth hormone in cells of the immune system.

GH1 GH2 CSH1 CSH2

2.59e-11554421741628
Pubmed

Structure of the growth hormone-encoding gene and its promoter in mice.

GH1 GH2 CSH1 CSH2

2.59e-1155448647448
Pubmed

Thiol-Disulfide Exchange in Human Growth Hormone.

GH1 GH2 CSH1 CSH2

2.59e-11554426887678
Pubmed

Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies.

GH1 GH2 CSH1 CSH2

2.59e-11554410810296
Pubmed

The role of growth hormone in fetal mouse reproductive tract differentiation.

GH1 GH2 CSH1 CSH2

2.59e-1155448756530
Pubmed

GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.

GH1 GH2 CSH1 CSH2

2.59e-11554431099824
Pubmed

Somatotropin transgenic mice have reduced jejunal active glucose transport rates.

GH1 GH2 CSH1 CSH2

2.59e-1155447965203
Pubmed

Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.

GH1 GH2 CSH1 CSH2

2.59e-1155441980158
Pubmed

Vitamin D3 cannot revert desensitization of growth hormone (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues.

GH1 GH2 CSH1 CSH2

2.59e-11554417881271
Pubmed

Neural growth hormone implicated in body weight sex differences.

GH1 GH2 CSH1 CSH2

2.59e-11554423861378
Pubmed

Growth hormone increases low-density lipoprotein receptor and HMG-CoA reductase mRNA expression in mesangial cells.

GH1 GH2 CSH1 CSH2

2.59e-11554412759574
Pubmed

Growth hormone production and action in N1E-115 neuroblastoma cells.

GH1 GH2 CSH1 CSH2

2.59e-11554419301152
Pubmed

Adipocyte insensitivity to insulin in growth hormone-transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554411350075
Pubmed

Transgenic mice overexpressing growth hormone (GH) have reduced or increased cardiac apoptosis through activation of multiple GH-dependent or -independent cell death pathways.

GH1 GH2 CSH1 CSH2

2.59e-11554418617616
Pubmed

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.

GH1 GH2 CSH1 CSH2

2.59e-11554417347312
Pubmed

Growth hormone and fertility in oMt1a-oGH transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554411570960
Pubmed

Promoter shuffling has occurred during the evolution of the vertebrate growth hormone gene.

GH1 GH2 CSH1 CSH2

2.59e-11554410974531
Pubmed

Pleiotropic effects of growth hormone signaling in aging.

GH1 GH2 CSH1 CSH2

2.59e-11554421852148
Pubmed

Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender.

GH1 GH2 CSH1 CSH2

2.59e-11554412175649
Pubmed

Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation.

GH1 GH2 CSH1 CSH2

2.59e-11554415070902
Pubmed

Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone.

GH1 GH2 CSH1 CSH2

2.59e-11554423428905
Pubmed

A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity.

GH1 GH2 CSH1 CSH2

2.59e-11554414726450
Pubmed

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.

GH1 GH2 CSH1 CSH2

2.59e-11554424758742
Pubmed

Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes.

GH1 GH2 CSH1 CSH2

2.59e-11554410076541
Pubmed

Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads.

GH1 GH2 CSH1 CSH2

2.59e-11554410594738
Pubmed

Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes.

GH1 GH2 CSH1 CSH2

2.59e-11554423639351
Pubmed

Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood.

GH1 GH2 CSH1 CSH2

2.59e-11554421098290
Pubmed

Cardiac expression of adenine nucleotide translocase-1 in transgenic mice overexpressing bovine GH.

GH1 GH2 CSH1 CSH2

2.59e-11554417761891
Pubmed

Age-related changes in body composition of bovine growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

2.59e-11554418948397
Pubmed

The human growth hormone locus: nucleotide sequence, biology, and evolution.

GH1 GH2 CSH1 CSH2

7.76e-1165442744760
Pubmed

Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.

GH1 GH2 CSH1 CSH2

7.76e-11654412399427
Pubmed

Transgenic mice over-expressing galanin exhibit pituitary adenomas and increased secretion of galanin, prolactin and growth hormone.

GH1 GH2 CSH1 CSH2

7.76e-11654414596666
Pubmed

GH modulates hepatic epidermal growth factor signaling in the mouse.

GH1 GH2 CSH1 CSH2

7.76e-11654420032199
Pubmed

Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.

GH1 GH2 CSH1 CSH2

7.76e-11654411316754
Pubmed

The use of transgenic mice to analyze the role of accessory factor two in the regulation of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes.

GH1 GH2 CSH1 CSH2

7.76e-11654411309401
Pubmed

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice.

GH1 GH2 CSH1 CSH2

7.76e-11654423150490
Pubmed

Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy.

GH1 GH2 CSH1 CSH2

7.76e-1165442991252
Pubmed

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.

GH1 GH2 CSH1 CSH2

7.76e-11654425017732
Pubmed

Third party data gene data set of eutherian growth hormone genes.

GH1 GH2 CSH1 CSH2

7.76e-11654426697363
Pubmed

Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness.

GH1 GH2 CSH1 CSH2

7.76e-11654410689811
Pubmed

Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse.

GH1 GH2 CSH1 CSH2

7.76e-11654415985453
Pubmed

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes.

GH1 GH2 CSH1 CSH2

7.76e-11654420863500
Pubmed

An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth.

GH1 GH2 CSH1 CSH2

7.76e-11654424949662
Pubmed

Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1.

GH1 GH2 CSH1 CSH2

7.76e-11654433539533
Pubmed

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

GH1 GH2 CSH1 CSH2

7.76e-11654420231469
Pubmed

Growth hormone resistance: clinical states and animal models.

GH1 GH2 CSH1 CSH2

7.76e-11654410556764
Pubmed

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.

GH1 GH2 CSH1 CSH2

7.76e-11654412208853
Pubmed

Involvement of growth hormone as a regulating factor in sex differences of mouse hepatic aldehyde oxidase.

GH1 GH2 CSH1 CSH2

7.76e-1165449175714
Pubmed

Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse.

GH1 GH2 CSH1 CSH2

7.76e-11654416141391
Pubmed

Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.

GH1 GH2 CSH1 CSH2

7.76e-11654418618017
Pubmed

Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.

GH1 GH2 CSH1 CSH2

7.76e-11654412166626
Pubmed

Growth hormone expression in murine bone marrow cells is independent of the pituitary transcription factor Pit-1.

GH1 GH2 CSH1 CSH2

7.76e-1165449275086
Pubmed

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

GH1 GH2 CSH1 CSH2

7.76e-11654423782652
Pubmed

Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.

GH1 GH2 CSH1 CSH2

7.76e-11654414759511
Pubmed

Age related changes in gene expression within the cochlea of C57BL/6J mice.

GH1 GH2 CSH1 CSH2

7.76e-11654423010755
Pubmed

Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice.

GH1 GH2 CSH1 CSH2

7.76e-11654425645493
Pubmed

Administration of human insulin-like growth factor-binding protein-1 increases circulating levels of growth hormone in mice.

GH1 GH2 CSH1 CSH2

7.76e-11654415166120
Pubmed

Osteocalcin induces growth hormone/insulin-like growth factor-1 system by promoting testosterone synthesis in male mice.

GH1 GH2 CSH1 CSH2

7.76e-11654424691732
Pubmed

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

GH1 GH2 CSH1 CSH2

7.76e-11654421725989
Pubmed

CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment.

GH1 GH2 CSH1 CSH2

7.76e-11654438951485
Pubmed

Evidence that growth hormone exerts a feedback effect on stomach ghrelin production and secretion.

GH1 GH2 CSH1 CSH2

7.76e-11654414530511
Pubmed

Growth hormone controls lipolysis by regulation of FSP27 expression.

GH1 GH2 CSH1 CSH2

7.76e-11654430400015
InteractionPCDHA7 interactions

PCDHA12 PCDHA10 PCDHA8 PCDHA4

3.87e-0814524int:PCDHA7
InteractionPCDHA12 interactions

PCDHA12 PCDHA10 PCDHA8 PCDHA4 CYP2S1

1.19e-0746525int:PCDHA12
InteractionPCDHA10 interactions

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.78e-0722524int:PCDHA10
InteractionCSH2 interactions

GH1 CSH1 CSH2

7.21e-0615523int:CSH2
InteractionGH1 interactions

GH1 CSH1 CSH2

8.86e-0616523int:GH1
InteractionPCDHA8 interactions

PCDHA12 PCDHA10 PCDHA8 PCDHA4

1.22e-0555524int:PCDHA8
InteractionCSH1 interactions

GH1 CSH1 CSH2

1.29e-0518523int:CSH1
InteractionCNNM1 interactions

HLA-E PCDHA12 PCDHA4 GCNT4

1.31e-0556524int:CNNM1
InteractionPCDHA11 interactions

PCDHA12 PCDHA10 PCDHA4

1.52e-0519523int:PCDHA11
InteractionPCDHGA10 interactions

PCDHA12 PCDHA8 PCDHA4

1.52e-0519523int:PCDHGA10
InteractionPCDHA4 interactions

PCDHA12 PCDHA10 PCDHA8 PCDHA4

1.73e-0560524int:PCDHA4
InteractionPCDHA13 interactions

PCDHA10 PCDHA8

1.36e-047522int:PCDHA13
InteractionCSHL1 interactions

CSH1 CSH2

1.36e-047522int:CSHL1
InteractionAPLNR interactions

MTOR TMEM161B TUBGCP3 CYP2S1 TAP1

2.09e-04211525int:APLNR
InteractionPCDHA6 interactions

PCDHA10 PCDHA8

2.32e-049522int:PCDHA6
InteractionPCDHA1 interactions

PCDHA8 PCDHA4

2.32e-049522int:PCDHA1
InteractionTMEM39A interactions

SLC39A12 PCDHA8 PCDHA4

2.75e-0449523int:TMEM39A
InteractionMFSD4A interactions

MTOR TM9SF3 TUBGCP3 CYP2S1 TAP1

2.81e-04225525int:MFSD4A
Cytoband17q24.2

GH1 GH2 CSH1 CSH2

4.58e-083054417q24.2
Cytoband5q31

PCDHA12 PCDHA10 PCDHA8 PCDHA4

1.07e-051155445q31
CytobandEnsembl 112 genes in cytogenetic band chr17q23

GH1 GH2 CSH1 CSH2

1.27e-05120544chr17q23
Cytoband10p12.33

SLC39A12 ST8SIA6

3.79e-05854210p12.33
Cytoband20q13.1

EYA2 CTSA

6.07e-051054220q13.1
CytobandEnsembl 112 genes in cytogenetic band chr5q31

PCDHA12 PCDHA10 PCDHA8 PCDHA4

4.26e-04298544chr5q31
GeneFamilyGrowth hormone family

GH1 GH2 CSH1 CSH2

2.22e-1063741175
GeneFamilyClustered protocadherins

PCDHA12 PCDHA10 PCDHA8 PCDHA4

8.64e-066437420
CoexpressionDESCARTES_FETAL_PLACENTA_TROPHOBLAST_GIANT_CELLS

GH1 GH2 CSH1 CSH2 INSL4

1.39e-0693545M40279
CoexpressionWANG_LSD1_TARGETS_DN

GH1 GH2 CSH1 CSH2

2.25e-0645544MM740
CoexpressionHOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN

GH1 GH2 CSH1 CSH2

5.86e-0657544MM807
CoexpressionZAMORA_NOS2_TARGETS_UP

GH1 GH2 CSH1 CSH2

7.20e-0660544MM1165
CoexpressionBREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

GH1 GH2 CSH1 CSH2

1.66e-0574544MM769
ComputationalNeighborhood of MMP11

GH2 CSH1 INSL4

1.35e-0442263GNF2_MMP11
ComputationalNeighborhood of TIMP2

GH2 CSH1 INSL4

1.78e-0446263GNF2_TIMP2
ComputationalNeighborhood of KISS1

GH2 CSH1 INSL4

2.15e-0449263GNF2_KISS1
Drugalpha-bromoergocriptine

GH1 GH2 ADCY4 CSH1 CSH2 TAP1

1.07e-06142546CID000002443
DrugCabergoline-d5

GH1 GH2 CSH1 CSH2 TAP1

1.57e-0683545CID000002512
Drug3'dGTP

GH1 GH2 CSH2

5.62e-0615543CID000148770
Drugalpha-methylhomocysteine-thiolactone

GH1 GH2 CSH2 CTSA

8.81e-0655544CID000133014
Drugbeta-carene

GH2 CSH2

1.65e-053542CID000011129
Drugprostaglandins G

GH1 GH2 CSH1 CSH2

2.44e-0571544CID000078964
DrugMK-677

GH1 GH2 CSH1 CSH2

2.72e-0573544CID000178024
DrugT-E-A-T

GH1 GH2 CSH1 CSH2

3.19e-0576544CID000086807
DrugZr-C

GH2 CSH2

3.30e-054542CID000449163
DrugC-S-S

GH1 GH2 CSH1 CSH2

3.91e-0580544CID000165331
Drug4-benzyloxybutyric acid

GH2 CSH2

5.50e-055542CID000562201
Drugnopinone

GH2 CSH2

5.50e-055542CID000032735
DrugBay P 8857

GH2 CSH2

5.50e-055542CID003086449
DrugNSC9700

GH1 GH2 ADCY4 POLR1A CSH1 CSH2 CYP2S1 MFRP

6.11e-05578548CID000005408
Drugatrazine

GH1 GH2 CSH2 INSL4

6.21e-0590544CID000002256
Drugpyridostigmine

GH1 GH2 CSH1 CSH2

7.06e-0593544CID000004991
DrugGHRP-6

GH1 GH2 CSH1 CSH2

7.99e-0596544CID004345065
Drug2brn

GH1 GH2 CSH1 CSH2

8.65e-0598544CID004369434
Druggadolinium

GH1 GH2 CSH1 CSH2 CTSA

1.08e-04199545CID000023982
DrugAC1L947I

THY1 TAP1

1.15e-047542CID000437680
DrugC 15

GH1 CSH1

1.15e-047542CID003014700
Drug16-PC

GH2 CSH2

1.15e-047542CID006454583
DrugSureCN160413

GH1 GH2 CSH2

1.17e-0440543CID011446521
Drughydroxylysine

GH2 COL4A6 CSH2 MFRP

1.31e-04109544CID000001029
Drug2-(ethylsulfonyl)ethanol

GH1 GH2 COL4A6 CSH1 CSH2

1.39e-04210545CID000010549
DrugAC1L3OEQ

GH2 CSH2

1.53e-048542CID000119216
DrugGH 5

GH1 GH2 CSH2

1.67e-0445543CID000163897
Druggly-pro

GH2 CSH1 CSH2 BIRC6

1.83e-04119544CID000079101
Drugboron monoxide

GH1 GH2 CSH1 CSH2

1.95e-04121544CID006327189
Drug2,6-t

GH2 CSH2

1.97e-049542CID000011331
DrugI82-2

GH2 CSH2

1.97e-049542CID000007899
DrugS2-o

GH2 CSH2

1.97e-049542CID000140772
DrugAC1O5E2B

GH2 CSH2

1.97e-049542CID002724224
DrugNSC20266

GH1 GH2 CSH1 CSH2

2.02e-04122544CID000000812
DrugTRH-T

GH1 GH2 CSH2

2.02e-0448543CID000032281
Diseaseisolated growth hormone deficiency type II (implicated_via_orthology)

GH1 GH2 CSH1 CSH2

5.00e-115544DOID:0060872 (implicated_via_orthology)
Diseaseisolated growth hormone deficiency (implicated_via_orthology)

GH1 GH2 CSH1 CSH2

3.49e-107544DOID:0060870 (implicated_via_orthology)
Diseasecongenital hypothyroidism (biomarker_via_orthology)

GH1 GH2 CSH1 CSH2

9.89e-0914544DOID:0050328 (biomarker_via_orthology)
Diseaseosteoporosis (biomarker_via_orthology)

GH1 GH2 CSH1 CSH2

7.15e-0822544DOID:11476 (biomarker_via_orthology)
Disease1,5 anhydroglucitol measurement

PCDHA12 PCDHA10 PCDHA8 PCDHA4

2.30e-0729544EFO_0008009
Diseasetype 1 diabetes mellitus (implicated_via_orthology)

GH1 GH2 CSH1 CSH2

7.86e-0739544DOID:9744 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

GH1 GH2 CSH1 CSH2 MTOR

7.45e-06147545DOID:9352 (biomarker_via_orthology)
Diseasevisceral adipose tissue measurement, body mass index

PCDHA12 PCDHA10 PCDHA8 PCDHA4

1.99e-0587544EFO_0004340, EFO_0004765
DiseaseRussell-Silver syndrome

GH2 CSH1

1.47e-0410542C0175693
DiseasePrimary microcephaly

RTTN TUBGCP3

7.42e-0422542C0431350
Diseaseneutrophil count, basophil count

PCDHA12 PCDHA10 PCDHA8 PCDHA4

7.59e-04224544EFO_0004833, EFO_0005090
Diseaseaspartate aminotransferase measurement

SLC39A12 ST8SIA6 MROH6 MTOR EYA2 GCNT4 BIRC6

1.25e-03904547EFO_0004736
DiseaseAbnormality of refraction

FER1L4 PCDHA12 PCDHA10 PCDHA8 PCDHA4 BIRC6

1.40e-03673546HP_0000539
Diseaseretinitis pigmentosa (is_implicated_in)

MFRP CNGB1

2.58e-0341542DOID:10584 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
LWLLLVTLCLTEELA

COL4A6

6

Q14031
QLESLLQLWLTLSLN

BIRC6

2656

Q9NR09
RVLEALWELLLQAIL

BAIAP3

916

O94812
ELKLLLLLLWLAASC

ADCY4

741

Q8NFM4
LLARLSLLTEQDLWT

ANGEL2

506

Q5VTE6
IILTLLWESSENLLT

CCDC180

1376

Q9P1Z9
LRLLAAICLLLLTWV

SLC7A8

161

Q9UHI5
LRTLARCLILWDDIL

ANAPC1

1406

Q9H1A4
SWLCVLLLSSLLLLL

MFRP

66

Q9BY79
SWRLLLLLLLLAAWK

PCDHA8

11

Q9Y5H6
LLLLLSEALALTQTW

HLA-E

6

P13747
ARWHLTLLLVLEDRL

NRBP2

436

Q9NSY0
LRLCELWLLLLGSSL

GLIPR1L2

26

Q4G1C9
LDRLWLETLLCLIGE

EIF4E1B

151

A6NMX2
RYWRTLVLLLLVLLT

FER1L4

1756

A9Z1Z3
LLRISLLLIESWLEP

CSH2

101

P0DML3
TWALLLALALLLLLT

CYP2S1

6

Q96SQ9
SAELSWLDLQLLEIL

KCNV1

231

Q6PIU1
LLLWLALLLSIQRRL

MFSD6L

531

Q8IWD5
LGLESSLTLRRLLVW

TUBGCP3

356

Q96CW5
ELSLLQNLRTLWIEA

LRRC10

116

Q5BKY1
LLREEVILERLLTWQ

MROH6

396

A6NGR9
AIWLLLSQLLRESLA

INSL4

11

Q14641
FEDLWLITNELILRL

BBS9

606

Q3SYG4
QCLLLSLLLLAAWEV

PCDHA10

11

Q9Y5I2
LLLLLLLLLVSWASR

CTSA

11

P10619
SRRLLLLLLLLAAWE

PCDHA4

11

Q9UN74
ESLVLLRRLLAWDLD

GAL3ST3

246

Q96A11
LTLWLLSLLKLLNVR

GCNT4

21

Q9P109
LLRISLLLIESWLEP

CSH1

101

P0DML2
TLRLSELDQLLNTLW

SLC39A12

246

Q504Y0
SQRLLLSLLLLAAWE

PCDHA12

11

Q9UN75
LEWLRRLSLELLKDS

MTOR

1281

P42345
LQLRAELEALTDLWL

EYA2

411

O00167
SSLELLNWILELLLR

RTTN

1161

Q86VV8
ELSLDRLRTLLQLKW

POLR1A

1186

O95602
SWRALRLLEESLLSL

SYNE3

736

Q6ZMZ3
FDTLRLWLIILLCAL

TMEM161B

311

Q8NDZ6
SLLWQREAITLSDLL

TAF1B

221

Q53T94
LQQLLLLLLENIREW

FAM178B

471

Q8IXR5
LRLALLILLTFILCW

GNRHR2

176

Q96P88
LASLLLLLLLRLLWC

ST8SIA6

11

P61647
VLLLLADWVLLRTAL

TAP1

26

Q03518
LRLLLWLEQNLERVL

CNGB1

156

Q14028
LLRISLLLIQSWLEP

GH2

101

P01242
ATKLVLILDDLLWVL

UHRF1BP1L

231

A0JNW5
LILDDLLWVLTDSQL

UHRF1BP1L

236

A0JNW5
EFLIWETALLLFLLR

PHTF1

646

Q9UMS5
KSLLLLEQREIWLLV

SPIDR

661

Q14159
LAQNTSWLLLLLLSL

THY1

136

P04216
SWLLLLLLSLSLLQA

THY1

141

P04216
TLLLILLRQWKRELG

NUP188

1161

Q5SRE5
LLRISLLLIQSWLEP

GH1

101

P01241
LWLLLLLLPRTRADE

TM9SF3

16

Q9HD45
WLQLQEADLSALRLL

XKR5

101

Q6UX68
LATDQLLLLWDRILG

TBC1D19

456

Q8N5T2
SRWEQVAALLLLLLL

WFIKKN2

11

Q8TEU8