Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	PHACTR2 MYL3 SYNE1 SPTB DST SYNE2 PHACTR4 MYO1F AFDN PPP1R9B DIXDC1 TNS4 FMNL1	5.97e-05	479	148	13	GO:0003779
GeneOntologyMolecularFunction	cytoskeletal protein binding	PHACTR2 MYL3 SYNE1 SPTB KIF1B OBSCN RMDN3 DES DST SYNE2 PHACTR4 MYO1F AFDN PPP1R9B DIXDC1 TNS4 KIF13A FMNL1 MTUS2 NLRP5	1.81e-04	1099	148	20	GO:0008092
GeneOntologyMolecularFunction	cadherin binding	CAST OBSCN CDH23 PPL TBC1D10A USO1 AFDN CDH6 SNX1 MPP7	2.24e-04	339	148	10	GO:0045296
GeneOntologyMolecularFunction	leptin receptor binding	SNX4 SNX1	3.24e-04	4	148	2	GO:1990460
GeneOntologyMolecularFunction	protein phosphatase inhibitor activity	PHACTR2 SH3RF2 PHACTR4 PPP1R9B	5.12e-04	50	148	4	GO:0004864
GeneOntologyMolecularFunction	cell adhesion molecule binding	CAST OBSCN CDH23 VSIG10 PPL POSTN DST TBC1D10A USO1 AFDN CDH6 SNX1 MPP7	5.28e-04	599	148	13	GO:0050839
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	5.38e-04	5	148	2	GO:0140444
GeneOntologyMolecularFunction	phosphatase inhibitor activity	PHACTR2 SH3RF2 PHACTR4 PPP1R9B	6.87e-04	54	148	4	GO:0019212
GeneOntologyMolecularFunction	enzyme regulator activity	ERBB3 GRIPAP1 RAP1A PHACTR2 TBC1D2B CAST OBSCN ARHGAP30 APOA4 RGS9 ANKLE2 TBC1D10A PIK3CA SH3RF2 RALBP1 MOB1B PHACTR4 MOB1A PPP1R9B C3 ARHGEF37 HERC1	7.68e-04	1418	148	22	GO:0030234
GeneOntologyMolecularFunction	protein phosphatase regulator activity	PHACTR2 ANKLE2 SH3RF2 PHACTR4 PPP1R9B	8.94e-04	100	148	5	GO:0019888
GeneOntologyCellularComponent	cell-cell contact zone	OBSCN DES DST PIK3CA AFDN RAP2C ATP2A2	4.95e-06	94	149	7	GO:0044291
GeneOntologyCellularComponent	anchoring junction	RAP1A RAP1B OBSCN VSIG10 YES1 PPL DES FRMD4A SLC8A3 NPHS2 DST PIK3CA SYNE2 AFDN PPP1R9B DIXDC1 TNS4 RAP2C ATP2A2 CDH6 MPP7	6.02e-06	976	149	21	GO:0070161
GeneOntologyCellularComponent	cell-cell junction	RAP1B OBSCN VSIG10 PPL DES FRMD4A NPHS2 DST PIK3CA AFDN PPP1R9B RAP2C ATP2A2 CDH6 MPP7	2.20e-05	591	149	15	GO:0005911
GeneOntologyCellularComponent	extrinsic component of postsynaptic endosome membrane	GRIPAP1 SNX1	5.05e-05	2	149	2	GO:0098999
GeneOntologyCellularComponent	intercalated disc	OBSCN DES DST PIK3CA ATP2A2	1.25e-04	68	149	5	GO:0014704
GeneOntologyCellularComponent	extrinsic component of endosome membrane	GRIPAP1 SNX1	3.00e-04	4	149	2	GO:0031313
GeneOntologyCellularComponent	type III intermediate filament	DES DST	7.43e-04	6	149	2	GO:0045098
Domain	Spectrin_repeat	DRP2 SYNE1 SPTB PPL DST SYNE2	8.78e-08	29	147	6	IPR002017
Domain	SPEC	DRP2 SYNE1 SPTB PPL DST SYNE2	1.64e-07	32	147	6	SM00150
Domain	Spectrin/alpha-actinin	DRP2 SYNE1 SPTB PPL DST SYNE2	1.64e-07	32	147	6	IPR018159
Domain	Spectrin	DRP2 SYNE1 SPTB DST SYNE2	8.47e-07	23	147	5	PF00435
Domain	GOLGA6L	GOLGA6L4 GOLGA6L10 GOLGA6L19	9.39e-06	6	147	3	IPR026737
Domain	ACTININ_2	SYNE1 SPTB DST SYNE2	2.90e-05	23	147	4	PS00020
Domain	ACTININ_1	SYNE1 SPTB DST SYNE2	2.90e-05	23	147	4	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 SPTB DST SYNE2	2.90e-05	23	147	4	IPR001589
Domain	CH	SYNE1 SPTB DST SYNE2 DIXDC1	1.59e-04	65	147	5	SM00033
Domain	CH	SYNE1 SPTB DST SYNE2 DIXDC1	2.26e-04	70	147	5	PF00307
Domain	-	SYNE1 SPTB DST SYNE2 DIXDC1	2.42e-04	71	147	5	1.10.418.10
Domain	CH	SYNE1 SPTB DST SYNE2 DIXDC1	2.76e-04	73	147	5	PS50021
Domain	CH-domain	SYNE1 SPTB DST SYNE2 DIXDC1	3.13e-04	75	147	5	IPR001715
Domain	SH3	OBSCN YES1 SH3D21 DST SH3RF2 MYO1F ARHGEF37 MPP7	3.17e-04	216	147	8	PS50002
Domain	GOLGA2L5	GOLGA6L4 GOLGA6L10 GOLGA6L19	3.57e-04	18	147	3	PF15070
Domain	Golgin_A	GOLGA6L4 GOLGA6L10 GOLGA6L19	3.57e-04	18	147	3	IPR024858
Domain	SH3_domain	OBSCN YES1 SH3D21 DST SH3RF2 MYO1F ARHGEF37 MPP7	3.58e-04	220	147	8	IPR001452
Domain	Kinesin-like_KIF1-typ	KIF1B KIF13A	3.65e-04	4	147	2	IPR022140
Domain	KASH	SYNE1 SYNE2	3.65e-04	4	147	2	IPR012315
Domain	KIF1B	KIF1B KIF13A	3.65e-04	4	147	2	PF12423
Domain	KASH	SYNE1 SYNE2	3.65e-04	4	147	2	PS51049
Domain	KASH	SYNE1 SYNE2	3.65e-04	4	147	2	SM01249
Domain	KASH	SYNE1 SYNE2	3.65e-04	4	147	2	PF10541
Domain	Kinesin_assoc	KIF1B KIF13A	9.04e-04	6	147	2	PF16183
Domain	SPOC_C	PHF3 SPEN	9.04e-04	6	147	2	IPR012921
Domain	Kinesin-like	KIF1B KIF13A	9.04e-04	6	147	2	IPR022164
Domain	Kinesin_assoc	KIF1B KIF13A	9.04e-04	6	147	2	IPR032405
Domain	DUF3694	KIF1B KIF13A	9.04e-04	6	147	2	PF12473
Domain	SPOC	PHF3 SPEN	9.04e-04	6	147	2	PF07744
Domain	PROTEIN_KINASE_TYR	ERBB3 INSRR OBSCN YES1 EPHA7	1.02e-03	97	147	5	PS00109
Domain	Tyr_kinase_AS	ERBB3 INSRR OBSCN YES1 EPHA7	1.02e-03	97	147	5	IPR008266
Domain	RPEL	PHACTR2 PHACTR4	1.26e-03	7	147	2	PS51073
Domain	RPEL	PHACTR2 PHACTR4	1.26e-03	7	147	2	SM00707
Domain	Plectin	PPL DST	1.26e-03	7	147	2	PF00681
Domain	Recep_L_domain	ERBB3 INSRR	1.26e-03	7	147	2	PF01030
Domain	Mob1_phocein	MOB1B MOB1A	1.26e-03	7	147	2	PF03637
Domain	Plectin_repeat	PPL DST	1.26e-03	7	147	2	IPR001101
Domain	Furin-like	ERBB3 INSRR	1.26e-03	7	147	2	PF00757
Domain	Rcpt_L-dom	ERBB3 INSRR	1.26e-03	7	147	2	IPR000494
Domain	RPEL	PHACTR2 PHACTR4	1.26e-03	7	147	2	PF02755
Domain	RAWUL	PCGF1 PCGF5	1.26e-03	7	147	2	IPR032443
Domain	Furin-like_Cys-rich_dom	ERBB3 INSRR	1.26e-03	7	147	2	IPR006211
Domain	RPEL_repeat	PHACTR2 PHACTR4	1.26e-03	7	147	2	IPR004018
Domain	-	ERBB3 INSRR	1.26e-03	7	147	2	3.80.20.20
Domain	MOB_kinase_act_fam	MOB1B MOB1A	1.26e-03	7	147	2	IPR005301
Domain	-	MOB1B MOB1A	1.26e-03	7	147	2	1.20.140.30
Domain	Mob1_phocein	MOB1B MOB1A	1.26e-03	7	147	2	SM01388
Domain	RAWUL	PCGF1 PCGF5	1.26e-03	7	147	2	PF16207
Domain	PLEC	PPL DST	1.26e-03	7	147	2	SM00250
Domain	FHA	KIF1B AFDN KIF13A	1.35e-03	28	147	3	SM00240
Domain	SH3	OBSCN YES1 SH3D21 SH3RF2 MYO1F ARHGEF37 MPP7	1.63e-03	216	147	7	SM00326
Domain	Calx_beta	FREM3 SLC8A3	1.67e-03	8	147	2	SM00237
Domain	FHA_DOMAIN	KIF1B AFDN KIF13A	1.83e-03	31	147	3	PS50006
Domain	FHA	KIF1B AFDN KIF13A	1.83e-03	31	147	3	PF00498
Domain	Calx_beta	FREM3 SLC8A3	2.14e-03	9	147	2	IPR003644
Domain	Calx-beta	FREM3 SLC8A3	2.14e-03	9	147	2	PF03160
Domain	Cadherin	CDH23 FREM3 CELSR1 PCDH19 CDH6	2.42e-03	118	147	5	IPR002126
Domain	Znf_C3HC4_RING-type	PCGF1 RNF114 PCGF5 TRIM10 SH3RF2 RLIM	2.43e-03	172	147	6	IPR018957
Domain	RAS	RAP1A RAP1B RAP2C	2.60e-03	35	147	3	PS51421
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	CEP104 USP34 KIF1B SARM1 ADAMTSL3 PPL GREB1 ECE2	2.39e-08	105	154	8	9628581
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	CEP104 USP34 SMG1 ERBB3 INSRR ZC3H4 FAM186A RLIM DIXDC1 HERC1 CTSD SPEN EPHA7	5.42e-08	420	154	13	28065597
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CYLC2 CEP104 SMG1 RAP1A RAP1B PHACTR2 NHSL2 SYNE1 ANKLE2 SH3D21 PPL DES DST FAM186A SYNE2 SEC23IP SMARCD2 PPP1R9B IFT122 UQCRB SPEN ATP2A2 CFAP46	1.05e-07	1442	154	23	35575683
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP104 USP34 SMG1 SATB2 TBC1D2B ANKLE2 KMT2C DST ATP11B WASHC5 ZC3H4 DIXDC1 LZTS2 FTO	1.13e-07	529	154	14	14621295
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RAP1A REXO4 SYNE1 CHD1 YES1 C2CD2L RIOX2 RMDN3 SCAF1 KMT2C CELSR1 DST TBC1D10A TCERG1 PHF3 SGPL1 ASCC2 AFDN LZTS2 RAP2C SPEN ATP2A2 MPP7	2.03e-07	1497	154	23	31527615
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	GRIPAP1 SNX4 RAP1B SYNE1 TBC1D2B YES1 USO1 PHACTR4 SEC23IP FMNL1 SNX1	3.73e-07	339	154	11	37232246
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 SMG1 SYNE1 C2CD2L KMT2C DST ZC3H4 PHF3 SYNE2	7.95e-07	225	154	9	12168954
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	SMG1 CENPB NHSL2 SYNE1 CYP20A1 ATP11B UBE2V2 SGPL1 PHACTR4 SEC23IP SMARCD2 AFDN HERC1 KIF13A EPHA7	8.06e-07	719	154	15	35337019
Pubmed	Rap1 regulates lumen continuity via Afadin in renal epithelia.	RAP1A RAP1B AFDN	2.94e-06	7	154	3	37276970
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	SYNE1 OBSCN DES ATP2A2	4.35e-06	25	154	4	38877142
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 ERBB3 SYNE1 SPTB KIF1B NSUN2 THOP1 DST TCERG1 CLK1 RALBP1 SEC23IP AFDN IFT122 HARS1 ATP2A2 MTUS2 SNX1 ECE2	4.46e-06	1285	154	19	35914814
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	ERBB3 PHACTR2 CAST PPL DST TBC1D10A USO1 PHACTR4 AFDN LZTS2 SNX1 MPP7	8.91e-06	565	154	12	25468996
Pubmed	Functional proteomics mapping of a human signaling pathway.	SMG1 ANKLE2 YES1 PPL DST ASCC2 AFDN PPP1R9B LZTS2 HERC1 KIF13A FMNL1	1.39e-05	591	154	12	15231748
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SMG1 COL12A1 SYNE1 SPTB KIF1B OBSCN DES DST CLK1 RALBP1 SYNE2	1.46e-05	497	154	11	23414517
Pubmed	Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.	RAP1A RAP1B	1.95e-05	2	154	2	13679863
Pubmed	Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.	RAP1A RAP1B	1.95e-05	2	154	2	25807985
Pubmed	Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy.	DES C3	1.95e-05	2	154	2	33897891
Pubmed	Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices.	COL12A1 C3	1.95e-05	2	154	2	9344363
Pubmed	Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle.	SYNE1 DES	1.95e-05	2	154	2	24943590
Pubmed	Phase Ib Study of Safety and Pharmacokinetics of the PI3K Inhibitor SAR245408 with the HER3-Neutralizing Human Antibody SAR256212 in Patients with Solid Tumors.	ERBB3 PIK3CA	1.95e-05	2	154	2	28031425
Pubmed	Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization.	EEF1AKMT4-ECE2 ECE2	1.95e-05	2	154	2	11718899
Pubmed	Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons.	SATB2 EPHA7	1.95e-05	2	154	2	34546353
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	1.95e-05	2	154	2	11792814
Pubmed	The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBPα.	CEBPA TCERG1	1.95e-05	2	154	2	26264132
Pubmed	Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.	RAP1A RAP1B	1.95e-05	2	154	2	34140948
Pubmed	TCERG1 inhibits C/EBPα through a mechanism that does not involve sequestration of C/EBPα at pericentromeric heterochromatin.	CEBPA TCERG1	1.95e-05	2	154	2	21503969
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	1.95e-05	2	154	2	24931616
Pubmed	Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.	RAP1A RAP1B	1.95e-05	2	154	2	29222111
Pubmed	Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1.	RAP1A RAP1B	1.95e-05	2	154	2	18305243
Pubmed	Mutation in RAP1 is a rare event in myelodysplastic syndromes.	RAP1A RAP1B	1.95e-05	2	154	2	16118622
Pubmed	Mutation analysis of RAP1 gene in papillary thyroid carcinomas.	RAP1A RAP1B	1.95e-05	2	154	2	18948674
Pubmed	Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.	RAP1A RAP1B	1.95e-05	2	154	2	9330640
Pubmed	Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.	RAP1A RAP1B	1.95e-05	2	154	2	24039860
Pubmed	Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.	RAP1A RAP1B	1.95e-05	2	154	2	31403469
Pubmed	CCAAT/enhancer-binding protein α is a crucial regulator of human fat mass and obesity associated gene transcription and expression.	CEBPA FTO	1.95e-05	2	154	2	24877091
Pubmed	Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.	RAP1A RAP1B	1.95e-05	2	154	2	18805968
Pubmed	The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands.	RAP1A RAP1B	1.95e-05	2	154	2	18191594
Pubmed	Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively.	RAP1A RAP1B	1.95e-05	2	154	2	2108841
Pubmed	Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.	RAP1A RAP1B	1.95e-05	2	154	2	18056377
Pubmed	Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.	RAP1A RAP1B	1.95e-05	2	154	2	18625726
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	1.95e-05	2	154	2	22768332
Pubmed	Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha.	CEBPA TCERG1	1.95e-05	2	154	2	16644732
Pubmed	Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.	MOB1B MOB1A	1.95e-05	2	154	2	30349003
Pubmed	Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.	MOB1B MOB1A	1.95e-05	2	154	2	23143302
Pubmed	Promotion of periostin expression contributes to the migration of Schwann cells.	ERBB3 POSTN	1.95e-05	2	154	2	26187852
Pubmed	Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.	RAP1A RAP1B	1.95e-05	2	154	2	3141412
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	1.95e-05	2	154	2	17267447
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	1.95e-05	2	154	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	1.95e-05	2	154	2	24586179
Pubmed	A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations.	ERBB3 PIK3CA	1.95e-05	2	154	2	25367220
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	1.95e-05	2	154	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	1.95e-05	2	154	2	31578382
Pubmed	The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction.	RAP1A RAP1B	1.95e-05	2	154	2	32651478
Pubmed	Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.	MOB1B MOB1A	1.95e-05	2	154	2	22454515
Pubmed	Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.	RAP1A RAP1B	1.95e-05	2	154	2	26804993
Pubmed	Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.	RAP1A RAP1B	1.95e-05	2	154	2	32184389
Pubmed	Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.	ERBB3 PIK3CA	1.95e-05	2	154	2	23633485
Pubmed	Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.	ERBB3 PIK3CA	1.95e-05	2	154	2	21725367
Pubmed	Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.	RAP1A RAP1B	1.95e-05	2	154	2	30796637
Pubmed	Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration.	RAP1A RAP1B	1.95e-05	2	154	2	23946483
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PHACTR2 ANKLE2 YES1 DST PIK3CA PCDH19 PHACTR4 SEC23IP SNX1 MPP7	1.98e-05	421	154	10	36976175
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	KIF1B DST SGPL1 MOB1B MOB1A AFDN PPP1R9B LZTS2 FMNL1 MPP7	3.23e-05	446	154	10	24255178
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RAP1A TUT4 SPTB KIF1B CAST OBSCN ARMC2 CERT1 DNAH14 GMPS KMT2C THOP1 ATP11B PPP1R9B IFT122 GREB1 LZTS2 ARHGEF37 SLC4A5	3.46e-05	1489	154	19	28611215
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 ERBB3 POLE NSUN2 DST TCERG1 WASHC5 ZC3H4 SGPL1 AFDN IFT122 KYNU	3.53e-05	650	154	12	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 REXO4 POLE CHD1 NSUN2 GMPS DST PHF3 SYNE2 AFDN SPEN ATP2A2	3.69e-05	653	154	12	22586326
Pubmed	Rap2A links intestinal cell polarity to brush border formation.	RAP1A RAP1B RAP2C	3.73e-05	15	154	3	22797597
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 GRIPAP1 REXO4 KIF1B PPL DST USO1 ZC3H4 PHACTR4 SEC23IP AFDN SPEN SNX1	4.56e-05	777	154	13	35844135
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RAP1A CAST ANKLE2 C2CD2L RMDN3 DST SYNE2 PHACTR4 SEC23IP FMNL1 SNX1	4.92e-05	568	154	11	37774976
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	USP34 SMG1 CHD1 YES1 PCGF5 DST ZC3H4 CLK1 RALBP1 MOB1B NRK MOB1A LZTS2 EPHA7	5.70e-05	910	154	14	36736316
Pubmed	Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.	RAP1A RAP1B	5.83e-05	3	154	2	24642466
Pubmed	Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release.	RAP1A RAP1B	5.83e-05	3	154	2	23616533
Pubmed	Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis.	PCGF1 CEBPA	5.83e-05	3	154	2	37266576
Pubmed	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.	MOB1B MOB1A	5.83e-05	3	154	2	34725466
Pubmed	Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice.	RAP1A RAP1B	5.83e-05	3	154	2	38010922
Pubmed	Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer.	ERBB3 PIK3CA	5.83e-05	3	154	2	25471734
Pubmed	Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.	RAP1A RAP1B	5.83e-05	3	154	2	32539601
Pubmed	The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.	MOB1B MOB1A	5.83e-05	3	154	2	16674920
Pubmed	Rap1 and its effector RIAM are required for lymphocyte trafficking.	RAP1A RAP1B	5.83e-05	3	154	2	26324702
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	5.83e-05	3	154	2	16079285
Pubmed	Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).	RAP1A RAP1B	5.83e-05	3	154	2	22577140
Pubmed	SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation.	SNX4 SNX1	5.83e-05	3	154	2	21973056
Pubmed	Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors.	CEBPA PPL	5.83e-05	3	154	2	10725330
Pubmed	Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B.	RAP1A RAP1B	5.83e-05	3	154	2	27760305
Pubmed	Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation.	F8 C3	5.83e-05	3	154	2	32582142
Pubmed	Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes.	RAP1A RAP1B	5.83e-05	3	154	2	20733035
Pubmed	CHD1 assumes a central role during follicle development.	CEBPA CHD1	5.83e-05	3	154	2	18817785
Pubmed	Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor.	RAP1A AFDN	5.83e-05	3	154	2	19887591
Pubmed	Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.	RAP1A RAP1B	5.83e-05	3	154	2	26714318
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	5.83e-05	3	154	2	10878022
Pubmed	Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells.	RAP1A RAP1B	5.83e-05	3	154	2	18422604
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	5.83e-05	3	154	2	12408964
Pubmed	Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941.	ERBB3 PIK3CA	5.83e-05	3	154	2	19411071
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	5.83e-05	3	154	2	17462627
Pubmed	Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.	RAP1A RAP1B	5.83e-05	3	154	2	26634692
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	5.83e-05	3	154	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	5.83e-05	3	154	2	25516977
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	RAP1A RAP1B MYL3 OBSCN DES WASHC5 AFDN CTSD	6.73e-05	304	154	8	32235678
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	USP34 GRIPAP1 DCPS KIF1B CAST CERT1 NSUN2 GMPS THOP1 WASHC5 PHACTR4 SEC23IP HARS1 HERC1 FTO KIF13A KYNU SNX1	8.36e-05	1455	154	18	22863883
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SYNE1 GMPS DST FAM186A HERC1 KIF13A SLC4A5	8.76e-05	234	154	7	36243803
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	CEBPA KMT2C ASCC2	9.18e-05	20	154	3	19047629
Interaction	NPAS1 interactions	GRIPAP1 SNX4 NHSL2 POLE TBC1D2B ANKLE2 WASHC5 SEC23IP RLIM IFT122 TNS4 HERC1	2.70e-07	245	148	12	int:NPAS1
Interaction	RAB11A interactions	GRIPAP1 SNX4 RAP1B REXO4 TBC1D2B ANKLE2 YES1 NSUN2 DST ATP11B USO1 SYNE2 PHACTR4 SEC23IP LZTS2 KIF13A FMNL1 SNX1 MPP7	1.11e-05	830	148	19	int:RAB11A
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	TCP11X1 DRP2 TCP11X2 NRK PCDH19 TAF7L	2.59e-05	172	153	6	chrXq22
Cytoband	15q25.2	ADAMTSL3 GOLGA6L4 GOLGA6L10	4.06e-04	43	153	3	15q25.2
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	1.84e-04	4	101	2	1252
GeneFamily	Phosphatase and actin regulators	PHACTR2 PHACTR4	1.84e-04	4	101	2	679
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB1B MOB1A	6.37e-04	7	101	2	647
GeneFamily	Ring finger proteins\|Polycomb group ring fingers	PCGF1 PCGF5	6.37e-04	7	101	2	61
GeneFamily	RAS type GTPase family	RAP1A RAP1B RAP2C	6.79e-04	31	101	3	389
GeneFamily	EF-hand domain containing\|Plakins	PPL DST	8.46e-04	8	101	2	939
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX4 SNX1	1.97e-03	12	101	2	1290
Coexpression	GSE14769_40MIN_VS_360MIN_LPS_BMDM_DN	RAP1B KDM5D ANKLE2 NXPE3 KMT2C OAF ZC3H4 TNS4 HERC1 SPEN	2.36e-07	199	150	10	M3517
Coexpression	GSE17721_0.5H_VS_8H_GARDIQUIMOD_BMDC_DN	SATB2 SNX4 RGS9 KDM5D CERT1 CHRD C3 ATP2A2 CDH6	2.31e-06	199	150	9	M4142
Coexpression	GENTILE_UV_RESPONSE_CLUSTER_D2	SATB2 SNX4 CHD1 ZC3H4 PHF3	2.47e-06	38	150	5	M12861
Coexpression	PUJANA_ATM_PCC_NETWORK	USP34 RAP1A SNX4 RAP1B PCGF1 POLE CAST OBSCN RNF114 BBS9 ATP11B TCERG1 WASHC5 ZC3H4 PHF3 SGPL1 RALBP1 SEC23IP MOB1A SMARCD2 KYNU FMNL1 ECE2	4.55e-06	1394	150	23	M9585
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	CEP104 SMG1 TUT4 POLE KMT2C PHACTR4 HERC1 ATP2A2	9.71e-06	180	150	8	M8239
Coexpression	DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP	CEP104 SATB2 DIPK1A KIF1B DST SGPL1 SYNE2 DLK2 DIXDC1 FTO	2.78e-05	340	150	10	M2012
Coexpression	GSE3920_IFNA_VS_IFNG_TREATED_ENDOTHELIAL_CELL_DN	CEP104 COL12A1 SQLE SH3RF2 DIXDC1 ATP2A2 EPHA7	5.15e-05	167	150	7	M6699
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1B INSRR KDM5D KMT2C DST CLK1 HERC1 ATP2A2	4.10e-07	195	154	8	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1B INSRR KDM5D KMT2C DST CLK1 HERC1 ATP2A2	4.10e-07	195	154	8	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 CAST CHD1 KMT2C CLK1 PHF3 SYNE2	4.96e-07	200	154	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL3 RAX POSTN DES NT5DC2 PCDH19 CDH6	3.40e-06	182	154	7	9edaccf1154cec92ca9a28e9b1f9075cfd422bfd
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL3 RAX POSTN DES NT5DC2 PCDH19 CDH6	3.40e-06	182	154	7	aba4c06d5d7618ac21b2695bca8e7a1346a91090
ToppCell	normal-na-Lymphocytic_NK-NK_dim-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 KDM5D YES1 SYNE2 MYO1F CTSD	3.78e-06	185	154	7	b1a8a8c4d0fc7605eabc17dcb6bd9e8ab4fd578c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 SYNE1 DNAH14 NRK SYNE2 CDH6 EPHA7	3.92e-06	186	154	7	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 SMG1 CHD1 KMT2C SYNE2 HERC1 SPEN	4.21e-06	188	154	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 SYNE1 DNAH14 PPL CELSR1 NEK11 EPHA7	4.21e-06	188	154	7	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP73 SYNE1 ARMC2 BBS9 DIXDC1 NEK11 CFAP46	5.00e-06	193	154	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CAPN12 RAP1B SYNE1 RGS9 YES1 SYNE2 MYO1F	5.35e-06	195	154	7	609732e83ab7fc3ba7dace66f5a17e46557fd6d1
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CAPN12 RAP1B SYNE1 RGS9 YES1 SYNE2 MYO1F	5.35e-06	195	154	7	acc603dc94ac6518adb0dffb43305b380ec75b52
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 SYNE1 KMT2C SLC9A4 SYNE2 HERC1	5.72e-06	197	154	7	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 SYNE1 CLK1 PHF3 SYNE2 HERC1	6.11e-06	199	154	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	USP34 TUT4 COL12A1 KMT2C DST SYNE2 AFDN	6.31e-06	200	154	7	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ERBB3 PPL CELSR1 DST SYNE2 AFDN ATP2A2	6.31e-06	200	154	7	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SYNE1 POSTN DES DST DIXDC1 CDH6 EPHA7	6.31e-06	200	154	7	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB3 PPL CELSR1 DST SYNE2 AFDN ATP2A2	6.31e-06	200	154	7	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	facs-Lung-nan-3m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPA ARHGAP30 WASHC5 MYO1F TNS4 ARHGEF37	1.74e-05	156	154	6	3f0b9e35d4da85c90759b930052e5b9c3cde9b15
ToppCell	facs-Lung-nan-3m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPA ARHGAP30 WASHC5 MYO1F TNS4 ARHGEF37	1.74e-05	156	154	6	69e6e8810d1738a66c9821910f41498931cf30cc
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYL3 OBSCN POSTN DES CHRD MTUS2	2.82e-05	170	154	6	cb1ed6bd409ee1cf11be0d5e7cdcffe2ab220d38
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYL3 OBSCN POSTN DES CHRD MTUS2	2.82e-05	170	154	6	da4fb1e186e9bec6bba0b25f2a0e68f9e11c6017
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SMG1 TUT4 SYNE1 CHD1 SYNE2 HERC1	2.91e-05	171	154	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CAPN12 ERBB3 SYNE1 YES1 SLC8A3 SYNE2	2.91e-05	171	154	6	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	NHSL2 SYNE1 FRMD4A C3 CDH6 EPHA7	3.01e-05	172	154	6	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NHSL2 SYNE1 ATP11B MYO1F HERC1 CTSD	3.01e-05	172	154	6	c05af6e559f6af0fb15cefa03ffa1413e98a1a4a
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NHSL2 SYNE1 ATP11B MYO1F HERC1 CTSD	3.01e-05	172	154	6	953b05f776348cff784e79c93df65841939d880f
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL3 POSTN DES NT5DC2 PCDH19 CDH6	3.31e-05	175	154	6	2a53d4f140d5ab096efe8118d8aa351db7838b49
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL3 POSTN DES NT5DC2 PCDH19 CDH6	3.31e-05	175	154	6	fb91a45763e4c48d993094a13088ffc19f1e2574
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN12 ERBB3 CEBPA TRIM10 CELSR1 HSD3B1	3.42e-05	176	154	6	24eedbbb406d788630bb16678cceef4492d3999c
ToppCell	facs-Heart-RV-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYL3 OBSCN DES ATP2A2 MTUS2 CFAP46	3.53e-05	177	154	6	692cd03bf0958ebeec34d41bfe87713a768e9a8e
ToppCell	facs-Heart-RV-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYL3 OBSCN DES ATP2A2 MTUS2 CFAP46	3.53e-05	177	154	6	c08583ea68bbeb6b5de852a46b0c0f04792dae55
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSRR F8 DST RLIM HERC1 ATP2A2	3.65e-05	178	154	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	COL12A1 NHSL2 SYNE1 FRMD4A DST C3	3.76e-05	179	154	6	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL3 RAX POSTN DES NT5DC2 PCDH19	3.76e-05	179	154	6	f5bb4d3a27d56698473219970e764084096cc582
ToppCell	facs-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL3 POSTN DES NT5DC2 PCDH19 CDH6	3.76e-05	179	154	6	7078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL3 RAX POSTN DES NT5DC2 PCDH19	3.76e-05	179	154	6	fa03ec3cc0132f977b4cb28e7b23789732375183
ToppCell	facs-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL3 POSTN DES NT5DC2 PCDH19 CDH6	3.76e-05	179	154	6	d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCell	droplet-Tongue-nan-24m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQLE PPL ATP11B RALBP1 ENTPD5 AFDN	4.25e-05	183	154	6	9e6c96ada930e8559246a270dfc69fb3cbb3bdf3
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL3 POSTN DES NT5DC2 PCDH19 CDH6	4.39e-05	184	154	6	4cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL3 POSTN DES NT5DC2 PCDH19 CDH6	4.39e-05	184	154	6	39bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMH+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SYNE1 KDM5D YES1 FAM186A SYNE2 MYO1F	4.52e-05	185	154	6	097d628f92e13250c15b550f2fd1f4225fc07558
ToppCell	Control-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	NTS POSTN DST OAF DLK2 TNS4	4.52e-05	185	154	6	d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNX4 RGS9 YES1 PHACTR4 PPP1R9B KIF13A	4.94e-05	188	154	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNX4 RGS9 YES1 PHACTR4 PPP1R9B KIF13A	4.94e-05	188	154	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNX4 RGS9 YES1 PHACTR4 PPP1R9B KIF13A	4.94e-05	188	154	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB2 SPTB RGS9 PPL CDH6 EPHA7	4.94e-05	188	154	6	c300accbac71a3bc075fe985543d8a8ead82531b
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL12A1 ANKLE2 PPL SH3RF2 NRK AFDN	4.94e-05	188	154	6	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 DNAH14 PPL CELSR1 SYNE2 EPHA7	5.09e-05	189	154	6	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-innate_lymphocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CAPN12 RAP1B SYNE1 RGS9 YES1 SYNE2	5.24e-05	190	154	6	1f890be1ac8613a098b271945f25a58c3c2530ab
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYL3 SPTB OBSCN ADAMTSL3 DES MTUS2	5.24e-05	190	154	6	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CAPN12 RAP1B SYNE1 RGS9 YES1 SYNE2	5.24e-05	190	154	6	d7cecf88451f736f8f3f6f4644504cf22846cd6e
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD8-Tem/emra_CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RAP1B TRAV6 SYNE1 RGS9 SYNE2 MYO1F	5.24e-05	190	154	6	66d29f53f129fc18771f6214316a913eeaccd55e
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RGS9 KDM5D SYNE2 MYO1F	5.40e-05	191	154	6	b2d0ea24970da09209da9d9dda76e30fbfe22917
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 DNAH14 PPL SYNE2 NEK11 EPHA7	5.40e-05	191	154	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	facs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CABP5 NTS YES1 F8 CELSR1 MPP7	5.40e-05	191	154	6	48823a97c38263f2c6e58348214f5b62773a6368
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	TUT4 CHD1 PIK3CA CLK1 PHF3 HERC1	5.40e-05	191	154	6	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CABP5 NTS YES1 F8 CELSR1 MPP7	5.40e-05	191	154	6	0eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ERBB3 TUT4 TCERG1 PHF3 AFDN GREB1	5.55e-05	192	154	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB OBSCN PM20D2 DES ATP2A2 MTUS2	5.55e-05	192	154	6	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SMG1 CHD1 KMT2C CLK1 SYNE2 HERC1	5.55e-05	192	154	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POSTN DES SLC8A3 SH3RF2 PCDH19 GREB1	5.55e-05	192	154	6	2cc712186e37fb21a964c032765c36a8b4a852cf
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RGS9 KDM5D SYNE2 MYO1F	5.55e-05	192	154	6	fdc741e1846cfd8ed741b160e3c611c310c5d36d
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB OBSCN PM20D2 DES ATP2A2 MTUS2	5.55e-05	192	154	6	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 DCPS NTS POSTN FRMD4A CDH6	5.72e-05	193	154	6	4f4f430d7e1b65e19ca829f55ca93edeb6c1c85d
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 SYNE1 ZKSCAN8 SLC9A4 SYNE2 HERC1	5.72e-05	193	154	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SPTB KDM5D TRIM10 FRMD4A ARHGEF37 HERC1	5.72e-05	193	154	6	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 SYNE1 PPL SYNE2 AFDN NEK11	5.88e-05	194	154	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL12A1 OBSCN ADAMTSL3 POSTN DES CDH6	5.88e-05	194	154	6	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH14 CELSR1 SYNE2 PHACTR4 AFDN CDH6	5.88e-05	194	154	6	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CAPN12 RAP1B SYNE1 RGS9 SYNE2 MYO1F	6.05e-05	195	154	6	72f42f0be53a2a61f61647118b4883e752d998a5
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CAPN12 RAP1B SYNE1 RGS9 SYNE2 MYO1F	6.05e-05	195	154	6	49a4f58aac168fc1838bd5d2b202135cd794c28b
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 NTS POSTN FRMD4A DST CDH6	6.05e-05	195	154	6	9fea1ddb68da83ca43dd8006c9e51295b1817f0e
ToppCell	normal-na-Lymphocytic_NK\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CAPN12 RAP1B SYNE1 YES1 SYNE2 MYO1F	6.05e-05	195	154	6	cebe79c42af5910353ba9ad7d0edb01982f772a3
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 NTS POSTN FRMD4A DST CDH6	6.23e-05	196	154	6	9afd0a7135028a446f06bb68f334e79b8f171b45
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB OBSCN PM20D2 DES ATP2A2 MTUS2	6.23e-05	196	154	6	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB OBSCN PM20D2 DES ATP2A2 MTUS2	6.23e-05	196	154	6	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_NK-NK_CD16\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE1 RGS9 YES1 SYNE2 MYO1F CTSD	6.23e-05	196	154	6	f7e5a7fad4547e8ab9ab8b140239281832fb4260
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RGS9 YES1 SYNE2 MYO1F	6.23e-05	196	154	6	c25f90c4e5abfe7cfaa85bfe136c438a5179c978
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RGS9 YES1 SYNE2 MYO1F	6.23e-05	196	154	6	d451f279f4086fcf727af712f98923551181c76e
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 PPL POSTN CELSR1 OAF EPHA7	6.23e-05	196	154	6	dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 RGS9 YES1 SYNE2 MYO1F CTSD	6.40e-05	197	154	6	f84263c5aaf3a5cd46d6e06358e8de6c6e6eaa3b
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP73 SYNE1 ARMC2 SYNE2 NEK11 CFAP46	6.40e-05	197	154	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RGS9 YES1 SYNE2 MYO1F	6.40e-05	197	154	6	550cce374332c49893bcf4ce4b7dceb7f5fe26aa
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SMG1 TUT4 CHD1 KMT2C PHF3 FMNL1	6.40e-05	197	154	6	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	normal-na-Lymphocytic_NK-natural_killer_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CAPN12 RAP1B SYNE1 YES1 SYNE2 MYO1F	6.40e-05	197	154	6	73a33d8b27043ba3074d04bc2d18cd287e00117f
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B TUT4 SYNE1 ARHGAP30 PHF3 SYNE2	6.59e-05	198	154	6	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD4+_CTL\|URO / Disease, condition lineage and cell class	DIPK1A SYNE1 SPTB RGS9 GOLGA6L10 SYNE2	6.59e-05	198	154	6	c53405a8d082fbd10131a6ec88b69fdd835f2925
ToppCell	Epithelial_cells-Basal_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	POSTN DST OAF DLK2 TNS4 CDH6	6.59e-05	198	154	6	4235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SMG1 TUT4 CHD1 KMT2C PHF3 FMNL1	6.59e-05	198	154	6	44417089b62056269cac38d3134ff209c05b7007
ToppCell	(0)_NK_cells-(0)_NK_FCGR3Apos\|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	RAP1B SYNE1 CAST RGS9 SYNE2 MYO1F	6.59e-05	198	154	6	eba39656c6f699ab297b652ded8cb9727b49593c
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ARMC2 NXPE3 DES DST SMARCD2 CDH6	6.59e-05	198	154	6	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	Bronchial_Biopsy\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	NTS POSTN DST SYNE2 DLK2 TNS4	6.59e-05	198	154	6	f5b7013045b61fc56894f80092f799770dde1c8f
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SMG1 TUT4 CHD1 KMT2C PHF3 FMNL1	6.59e-05	198	154	6	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RGS9 YES1 SYNE2 MYO1F	6.59e-05	198	154	6	5607e36f393cb399fcc2504502498453fd32d96b
ToppCell	T/NK_cells-CD8+_Naive_T_cell\|T/NK_cells / Lineage and Cell class	RAP1B CAST SYNE2 MYO1F CTSD FMNL1	6.59e-05	198	154	6	5b78118af2283f2e1ad9c6a6ab448a018bf2f2e0
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SYNE1 POSTN DES DST DIXDC1 EPHA7	6.77e-05	199	154	6	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	COL12A1 ADAMTSL3 CERT1 OAF NRK C3	6.77e-05	199	154	6	8de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	PHACTR2 DST PHF3 RALBP1 SYNE2 RLIM	6.77e-05	199	154	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL12A1 SPTB DES NT5DC2 CHRD CDH6	6.77e-05	199	154	6	7c272a1aa7f3e931ad5d20809719d85b3bce4cb0
Disease	FEV/FEC ratio	USP34 ERBB3 DIPK1A SOX30 KIF1B CDH23 ADAMTSL3 ARMC2 SH3D21 DES FRMD4A DST SYNE2 MYO1F ASCC2 HERC1 FTO KIF13A MPP7	1.46e-05	1228	149	19	EFO_0004713
Disease	Vascular anomaly	YES1 PIK3CA	2.53e-05	2	149	2	C0158570
Disease	age at menarche	CYLC2 USP34 EEF1AKMT4-ECE2 SATB2 CAST DST ZC3H4 NT5DC2 SEC23IP GREB1 FTO ECE2	5.16e-05	594	149	12	EFO_0004703
Disease	Malignant Head and Neck Neoplasm	ERBB3 CEBPA FANCF PIK3CA	7.24e-05	44	149	4	C0278996
Disease	Prostatic Neoplasms	ERBB3 CHD1 PPL KMT2C USO1 PIK3CA RALBP1 RLIM HSD3B1 GREB1 CTSD SPEN	7.29e-05	616	149	12	C0033578
Disease	Malignant neoplasm of prostate	ERBB3 CHD1 PPL KMT2C USO1 PIK3CA RALBP1 RLIM HSD3B1 GREB1 CTSD SPEN	7.29e-05	616	149	12	C0376358
Disease	Benign neoplasm of stomach	ERBB3 POLE PIK3CA	8.15e-05	17	149	3	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB3 POLE PIK3CA	8.15e-05	17	149	3	C0496905
Disease	Carcinoma in situ of stomach	ERBB3 POLE PIK3CA	8.15e-05	17	149	3	C0154060
Disease	Adenocarcinoma of large intestine	POLE PIK3CA NRK NEK11 EPHA7	1.30e-04	96	149	5	C1319315
Disease	Kabuki make-up syndrome	RAP1A RAP1B	1.51e-04	4	149	2	C0796004
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	1.51e-04	4	149	2	cv:CN293514
Disease	Stomach Carcinoma	ERBB3 POLE PIK3CA	1.57e-04	21	149	3	C0699791
Disease	Nasopharyngeal carcinoma	ERBB3 SYNE1 PIK3CA	1.81e-04	22	149	3	C2931822
Disease	Colorectal Carcinoma	SATB2 SYNE1 POLE OBSCN CHD1 ADAMTSL3 POSTN KMT2C PIK3CA TNS4 LZTS2 EPHA7	2.45e-04	702	149	12	C0009402
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	2.51e-04	5	149	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	2.51e-04	5	149	2	C0410190
Disease	non-lobar intracerebral hemorrhage	CYP20A1 DNAH14 FRMD4A FTO	2.95e-04	63	149	4	EFO_0010178
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	3.75e-04	6	149	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	3.75e-04	6	149	2	C0410189
Disease	Usher syndrome	CDH23 HARS1	5.23e-04	7	149	2	cv:C0271097
Disease	CUB domain-containing protein 1 measurement	DCPS SARM1	5.23e-04	7	149	2	EFO_0802432
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	5.23e-04	7	149	2	C0751337
Disease	Head and Neck Neoplasms	ERBB3 CEBPA PIK3CA	6.16e-04	33	149	3	C0018671
Disease	zinc-alpha-2-glycoprotein measurement	SARM1 NPHS2	6.95e-04	8	149	2	EFO_0802228
Disease	calcium/calmodulin-dependent protein kinase type 1D measurement	SARM1 C3	6.95e-04	8	149	2	EFO_0008063
Disease	mean reticulocyte volume	CEBPA DIPK1A SPTB CHD1 ARMC2 TRIM10 PIK3CA SGPL1 MOB1B SEC23IP AFDN CDH6	7.72e-04	799	149	12	EFO_0010701
Disease	chronic obstructive pulmonary disease	ERBB3 KIF1B FREM3 ADAMTSL3 ARMC2 DES FRMD4A ASCC2 FTO KIF13A ATP2A2	7.73e-04	688	149	11	EFO_0000341
Disease	apolipoprotein A-V measurement	SARM1 APOA4	8.91e-04	9	149	2	EFO_0801387
Disease	cellular retinoic acid-binding protein 1 measurement	SARM1 C3	8.91e-04	9	149	2	EFO_0801463
Disease	membranous glomerulonephritis (implicated_via_orthology)	NPHS2 C3	8.91e-04	9	149	2	DOID:10976 (implicated_via_orthology)
Disease	tumor necrosis factor ligand superfamily member 14 measurement	SARM1 C3	8.91e-04	9	149	2	EFO_0010613
Disease	reticulocyte measurement	USP34 CEBPA DIPK1A SPTB RGS9 SH3D21 TRIM10 ATP11B PIK3CA ZC3H4 SGPL1 SYNE2 ASCC2 AFDN	9.32e-04	1053	149	14	EFO_0010700
Disease	abdominal aortic aneurysm (is_marker_for)	POSTN FTO	1.11e-03	10	149	2	DOID:7693 (is_marker_for)
Disease	OCIA domain-containing protein 1 measurement	SARM1 C3	1.11e-03	10	149	2	EFO_0008252
Disease	Head and Neck Carcinoma	ERBB3 PIK3CA	1.11e-03	10	149	2	C3887461
Disease	Uterine leiomyoma	SYNE1 ARMC2 GREB1 RAP2C	1.19e-03	91	149	4	HP_0000131
Disease	Charcot-Marie-Tooth disease	DRP2 KIF1B SGPL1	1.25e-03	42	149	3	cv:C0007959
Disease	obsolete_red blood cell distribution width	DIPK1A SPTB CDH23 FREM3 BBS9 F8 TRIM10 FRMD4A ATP11B ZC3H4 SGPL1 MOB1B SYNE2 AFDN HERC1 FTO	1.32e-03	1347	149	16	EFO_0005192
Disease	nasopharynx carcinoma (is_marker_for)	ERBB3 KMT2C SPEN	1.34e-03	43	149	3	DOID:9261 (is_marker_for)
Disease	schizophrenia, gastroesophageal reflux disease	SATB2 ATP2A2	1.35e-03	11	149	2	EFO_0003948, MONDO_0005090
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	1.62e-03	12	149	2	DOID:11726 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (biomarker_via_orthology)	KIF1B C3	1.90e-03	13	149	2	DOID:332 (biomarker_via_orthology)
Disease	Alzheimer's disease (is_marker_for)	PHACTR2 CEBPA CAST SLC8A3 PPP1R9B CTSD	2.00e-03	257	149	6	DOID:10652 (is_marker_for)
Disease	Nephrosis	DES NPHS2	2.55e-03	15	149	2	C0027720
Disease	Synostotic Posterior Plagiocephaly	BBS9 IFT122	2.90e-03	16	149	2	C1833340
Disease	Craniosynostosis, Type 1	BBS9 IFT122	2.90e-03	16	149	2	C4551902
Disease	Acrocephaly	BBS9 IFT122	2.90e-03	16	149	2	C0030044
Disease	Trigonocephaly	BBS9 IFT122	2.90e-03	16	149	2	C0265535
Disease	Scaphycephaly	BBS9 IFT122	2.90e-03	16	149	2	C0265534
Disease	Synostotic Anterior Plagiocephaly	BBS9 IFT122	2.90e-03	16	149	2	C2931150
Disease	Metopic synostosis	BBS9 IFT122	2.90e-03	16	149	2	C1860819
Disease	Colorectal Neoplasms	SATB2 SYNE1 POLE CHD1 POSTN PIK3CA	2.91e-03	277	149	6	C0009404
Disease	adult onset asthma	ERBB3 CEBPA ADAMTSL3 SLC9A4	3.07e-03	118	149	4	EFO_1002011
Disease	Brachycephaly	BBS9 IFT122	3.28e-03	17	149	2	C0221356
Disease	Malignant neoplasm of skin	ERBB3 CEBPA POLE	3.34e-03	59	149	3	C0007114
Disease	Skin Neoplasms	ERBB3 CEBPA POLE	3.34e-03	59	149	3	C0037286
Disease	smoking behavior, BMI-adjusted waist circumference	KIF1B ADAMTSL3 NT5DC2 MYO1F	3.46e-03	122	149	4	EFO_0004318, EFO_0007789
Disease	disease progression measurement	CDH23 CELSR1 HERC1	3.67e-03	61	149	3	EFO_0008336
Disease	essential hypertension (is_implicated_in)	FTO ATP2A2	3.67e-03	18	149	2	DOID:10825 (is_implicated_in)
Disease	mean arterial pressure	GRIPAP1 MYL3 YES1 PPL FANCF OAF FTO ATP2A2	3.96e-03	499	149	8	EFO_0006340
Disease	Sarcomatoid Renal Cell Carcinoma	PIK3CA SYNE2 HARS1 CTSD	4.10e-03	128	149	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	PIK3CA SYNE2 HARS1 CTSD	4.10e-03	128	149	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	PIK3CA SYNE2 HARS1 CTSD	4.10e-03	128	149	4	C1266044
Disease	Papillary Renal Cell Carcinoma	PIK3CA SYNE2 HARS1 CTSD	4.10e-03	128	149	4	C1306837
Disease	Renal Cell Carcinoma	PIK3CA SYNE2 HARS1 CTSD	4.10e-03	128	149	4	C0007134
Disease	Disorder of eye	CDH23 RGS9 BBS9 HARS1 CTSD	4.53e-03	212	149	5	C0015397
Disease	chronic kidney disease (is_marker_for)	APOA4 POSTN	4.53e-03	20	149	2	DOID:784 (is_marker_for)
Disease	Craniosynostosis	BBS9 IFT122	4.53e-03	20	149	2	C0010278
Disease	brain age measurement	EEF1AKMT4-ECE2 ECE2	4.53e-03	20	149	2	EFO_0010602
Disease	memory performance	CAPN12 KIF1B ARMC2 BBS9 NT5DC2 SYNE2 CFAP46	4.88e-03	409	149	7	EFO_0004874
Disease	ST2 protein measurement	DCPS SLC9A4	4.99e-03	21	149	2	EFO_0010599
Disease	Infiltrating duct carcinoma of female breast	SMG1 NRK	4.99e-03	21	149	2	C3165106

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERRLDIDEKPLVVQL	AFDN	101	P55196
RLAEVPDLLEKGERL	ERBB3	916	P21860
RLKLLNPDDLREEIV	ANKLE2	71	Q86XL3
EIRVLDKAFGPELRE	HSD3B1	31	P14060
RKEPELQRHIQGIVE	ARHGEF37	136	A1IGU5
TRIVPILRELEKEEN	ARMC2	271	Q8NEN0
QVLRTKVPREGQEED	ASCC2	646	Q9H1I8
KPVQDLRQDLRDGVI	DIXDC1	41	Q155Q3
EGLQVEEKERPVQRL	CFAP46	2251	Q8IYW2
TLDPERLGREGVQKE	C3	946	P01024
IIDEEQLRGDRRQPL	CYLC2	61	Q14093
DISRRENGEVLPLKI	CELSR1	2456	Q9NYQ6
PVLRLLEKRQELVDA	CFAP73	31	A6NFT4
PQLGKRKRELDVEEA	DCPS	6	Q96C86
PVEGVLRVRKDVELD	CDH23	1796	Q9H251
LDRPEKGLSEREQLE	CHD1	1431	O14646
RDERTLINPDIKVVD	CLK1	311	P49759
DSKPLDVIEEERRLG	MTUS2	446	Q5JR59
LPETQAGIKEEIRRQ	RALBP1	391	Q15311
LREQILRVKDTEDVP	RAP1A	96	P62834
LREQILRVKDTDDVP	RAP1B	96	P61224
LILVGNKVDLEPERE	RAP2C	111	Q9Y3L5
DEDVKEAIRRLPENL	UQCRB	41	P14927
PVILRQLEEEAKARE	RGS9	446	O75916
IPRLQIDVDGRKEIL	NSUN2	246	Q08J23
EIGKELEELRARLLP	APOA4	101	P06727
RREVEENGIVLDPLK	CERT1	431	Q9Y5P4
ISKNDIRLVPRDVEE	PCDH19	781	Q8TAB3
EEIIFKLVPGLREQE	PCGF5	76	Q86SE9
KLVPGLREQELERES	PCGF5	81	Q86SE9
EVLRVVRGKLHQPEE	ENTPD5	306	O75356
LERLQEVGKAEAERP	FANCF	171	Q9NPI8
PEEQLVIERLQGEKE	KMT2C	711	Q8NEZ4
IDLEVLRPKRDDRQL	IFT122	1111	Q9HBG6
EREQRELGPRLEETK	LZTS2	426	Q9BRK4
ELERNRQEELGIKPQ	GREB1	1621	Q4ZG55
EVLRVLGKPRQEELN	MYL3	91	P08590
KIGVIRLLDPEDVDV	DST	221	Q03001
VKREGLPVEQRNEIL	FTO	421	Q9C0B1
VGRIRNKPEVDEAAV	KIF1B	1316	O60333
VSPVIDELQKRREEG	HERC1	1456	Q15751
RDLPVGLEELRQLEL	KDM5D	1046	Q9BY66
IAEKQRERPLGQDEI	CABP5	16	Q9NP86
ERIEELGAQPLRDLI	ECE2	231	P0DPD6
RPLSDIEGARELQEK	KIAA1586	261	Q9HCI6
LEALRRRGPQVEVKE	PPL	1216	O60437
REVNGIPVEDKRPEE	MPP7	186	Q5T2T1
EIALERPEKEIRNEG	NEK11	496	Q8NG66
ERIEIKDVRLPAGLQ	NPHS2	261	Q9NP85
EKLPGQERLLEEVEK	GOLGA6L3	331	A6NEY3
QEKLPGQERLLEEVE	GOLGA6L4	316	A6NEF3
LPGQERLLEEVEKLL	GOLGA6L10	326	A6NI86
QEKLPGQERLLEEVE	GOLGA6L19	351	H0YKK7
QFRLPLEETELEKRI	F8	1336	P00451
ALEIDPTVQRVKRDE	KRT82	106	Q9NSB4
LEEVQLLKPRVVIDG	NLRP5	1171	P59047
IDRRELAPLQELIEK	MOB1B	196	Q7L9L4
ARELIEQIGRPLELD	POLE	846	Q07864
IRRGVLKELPDQDGD	PHACTR2	76	O75167
ERAERPKFEQIVGIL	EPHA7	876	Q15375
EELVKRGVLLEDPEQ	PHACTR4	76	Q8IZ21
VIEPVGNREEKILNR	PIK3CA	101	P42336
EVDLRDPVLQVEVGK	BBS9	71	Q3SYG4
LDEPAELGLRERVKA	OBSCN	7406	Q5VST9
GEVHEEELVARRKLP	NTS	76	P30990
QKILPKGEEAELERL	FRMD4A	451	Q9P2Q2
QVERIEELGAQPLRD	EEF1AKMT4-ECE2	301	P0DPD8
EELGAQPLRDLIEKI	EEF1AKMT4-ECE2	306	P0DPD8
VEIAVGDKVPADIRL	ATP2A2	151	P16615
DVVVDDRLPVREGKL	CAPN12	151	Q6ZSI9
IIQEVEENPDLRKGE	CENPB	16	P07199
QDPEVAQIIRKLDER	CEP104	206	O60308
ELLEREARGEVKVTP	IDI2	181	Q9BXS1
ELIRKLREEGKVIEP	GMPS	396	P49915
KDEVRILGRELGLPE	GMPS	416	P49915
PKLQARERGEEQVEL	C2CD2L	221	O14523
GKSQDEVEIPARELR	COL12A1	251	Q99715
RPLVIKQEPREEDEA	CEBPA	156	P49715
DEVRELQKAIGAVPL	CTSD	306	P07339
RKLLEGEESRINLPI	DES	406	P17661
VIERDLKEPDRIVGE	SQLE	151	Q14534
PKDDDVIRNIIRLRE	DNAH14	251	Q0VDD8
RQAEPELDLRSIKEV	CAST	301	P20810
EIQEDKVPRERAVLS	INSRR	761	P14616
EELEEKGLIRILRGP	FMNL1	481	O95466
EAIEDNKLRRDIVPE	CDH6	681	P55285
LQDIEGKIDRFIIPR	CYP20A1	346	Q6UW02
VKEVVRRQEAGLGEP	DLK2	291	Q6UY11
PERGLEDLERQIKTK	FAM186A	971	A6NE01
VLRDLVKPGDENLRE	GRIPAP1	776	Q4V328
RGAPSEIREELEKQL	DIPK1A	376	Q5T7M9
REELAKEIGVPESRV	DUXA	131	A6NLW8
REDLVEEIKRRTGQP	HARS1	491	P12081
ERLEEERGILVNVPL	DRP2	456	Q13474
LVPGLQDSEEKRIRE	PCGF1	111	Q9BSM1
EAVGVQLEPERLVKI	ARHGAP30	116	Q7Z6I6
DPNAKVIRELREEVE	KIF13A	361	Q9H1H9
GIPLIFEREEAIKEQ	NRK	341	Q7Z2Y5
KIEEDIGELLIPVRR	FREM3	1896	P0C091
IRPENLKQGEELEVV	REXO4	296	Q9GZR2
IESPDVENEVKRLLR	TAF7L	256	Q5H9L4
GIQPEEIGRLREEIE	USO1	726	O60763
SLPREGQEKVLDRLD	RMDN3	81	Q96TC7
ETPEQREARIKVLEE	SNX4	366	O95219
PDELALRRGDVVKVL	SH3D21	81	A4FU49
PVRDEAIQKLETIRD	TCP11X1	171	B4DZS4
PVRDEAIQKLETIRD	TCP11X2	76	Q5H9J9
LENIDRRKNEIVPID	SYNE1	8566	Q8NF91
LKQEQEGVERDRLPA	SYNE2	4071	Q8WXH0
VEDEGPKVRVLPERI	NHSL2	971	Q5HYW2
SEGIRVLQRLQEDKP	NXPE3	191	Q969Y0
IDRRELAPLQELIEK	MOB1A	196	Q9H8S9
EGVRLLPREKSEVQN	SMG1	1641	Q96Q15
QGLLSEILRKEEDPR	SATB2	391	Q9UPW6
QRIQGIKRLSPEDVE	SLC9A4	576	Q6AI14
PRVVKRGIDDNLDEI	SEC23IP	421	Q9Y6Y8
ELRVRVRLPDGQVTE	OAF	31	Q86UD1
LDVIFKPELLEGIRE	PM20D2	406	Q8IYS1
AIREGVIKTEEPERL	SOX30	206	O94993
REELAGKVNLPEVRV	RAX	166	Q9Y2V3
DIFPGLRKIEAEIVR	SGPL1	176	O95470
RRDLKIITDVIGNPE	SMARCD2	476	Q92925
EAQGVVKDLEPELLR	CHRD	606	Q9H2X0
RVGDIVRIAKDEIFP	ATP11B	141	Q9Y2G3
LREQILRVKDTDDVP	nan	96	A6NIZ1
DPKQLLEDGIRKELV	WASHC5	701	Q12768
EVILLREGEAERKPV	SPEN	1026	Q96T58
VREFLEKEELPRAVG	SNX1	261	Q13596
LAPGVRAVELERQIE	RNF114	71	Q9Y508
GVILNLAKEREPVEL	SARM1	166	Q6SZW1
DLIGRADVDKIIQEP	TCERG1	561	O14776
REQAIELLRKEEPGA	TNS4	456	Q8IZW8
ELLRKEEPGAFVIRD	TNS4	461	Q8IZW8
LELVAEVRIGDRDPI	SCAF1	126	Q9H7N4
EEELLRRLQQIKEGP	RLIM	61	Q9NVW2
ELILPNRNLRDKVEE	PHF3	106	Q92576
IEKQIEDGLLRPELR	SLC4A5	191	Q9BY07
LKERQIAERPAEETG	SPTB	2076	P11277
GAIIPELEREIRIIN	NT5DC2	376	Q9H857
KEDVELRTGIPRQLL	RIOX2	281	Q8IUF8
EEGERALREKAVNIP	ZC3H4	926	Q9UPT8
EDVQRKGELRLRPEE	TRIM10	386	Q9UDY6
GVKVPRNFRLLEELE	UBE2V2	6	Q15819
QEGAREREELPKEIP	VSIG10	481	Q8N0Z9
PDELDLQKGEGVRVL	SH3RF2	396	Q8TEC5
IPIGNKKEEEELRRT	USP34	496	Q70CQ2
NEAFEKLPRGVLERI	POSTN	276	Q15063
EKETREERIITGPEI	POSTN	746	Q15063
DEEIKRLLQGDTPVR	POSTN	801	Q15063
VPRELLEKLIESRQA	THOP1	531	P52888
PEQRLGLKQAEERLE	TUT4	271	Q5TAX3
LEEVPLEVLRQRESK	TBC1D10A	71	Q9BXI6
EQLLGEEPEKRRRQE	TCHH	971	Q07283
VVPVARDQLELDRLK	TBC1D2B	476	Q9UPU7
RGPVFLLLIRENEKE	TRAV6	81	A0A075B6T7
LEDLERQIDILGRPV	ZKSCAN8	126	Q15776
EIPRESLRLEVKLGQ	YES1	271	P07947
EKREENVIAVPLGSR	ADAMTSL3	241	P82987
KPREGEETLRIEDIL	KYNU	191	Q16719
LEERPELRQFLGKRE	MYO1F	746	O00160
LVPLEGKEVDESRRE	SLC8A3	301	P57103
EKRVERLELFPVELE	PPP1R9B	486	Q96SB3