Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionMAP kinase kinase kinase activity

MAP3K3 MAP3K5 MAP3K9 MAP3K2

8.78e-0627984GO:0004709
DomainRCC1

MYCBP2 RCC1 NEK8

1.28e-0420933PF00415
DomainJunctophilin

JPH4 JPH2

1.46e-044932IPR017191
DomainRCC1_1

MYCBP2 RCC1 NEK8

1.49e-0421933PS00625
DomainRCC1_2

MYCBP2 RCC1 NEK8

1.49e-0421933PS00626
DomainRCC1_3

MYCBP2 RCC1 NEK8

1.49e-0421933PS50012
DomainReg_chr_condens

MYCBP2 RCC1 NEK8

1.72e-0422933IPR000408
Domain-

MYCBP2 RCC1 NEK8

1.72e-04229332.130.10.30
DomainRCC1/BLIP-II

MYCBP2 RCC1 NEK8

1.97e-0423933IPR009091
DomainGAR

GAS2 DST

3.63e-046932PS51460
Domain-

GAS2 DST

3.63e-0469323.30.920.20
DomainGAS_dom

GAS2 DST

3.63e-046932IPR003108
DomainGAS2

GAS2 DST

3.63e-046932PF02187
DomainGAS2

GAS2 DST

3.63e-046932SM00243
DomainKinase-like_dom

OBSCN SRMS MAP3K3 MAP3K5 DST NEK8 MAP3K9 ATM DCLK1 MAP3K2

3.64e-045429310IPR011009
DomainSer/Thr_kinase_AS

OBSCN MAP3K3 MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

2.04e-03357937IPR008271
DomainPROTEIN_KINASE_ATP

OBSCN SRMS MAP3K3 MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

2.06e-03459938PS00107
DomainS_TKc

OBSCN MAP3K3 MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

2.10e-03359937SM00220
DomainMORN

JPH4 JPH2

2.15e-0314932SM00698
DomainPB1

MAP3K3 MAP3K2

2.15e-0314932SM00666
DomainPB1

MAP3K3 MAP3K2

2.15e-0314932PF00564
DomainPB1

MAP3K3 MAP3K2

2.15e-0314932PS51745
DomainPB1_dom

MAP3K3 MAP3K2

2.15e-0314932IPR000270
DomainPROTEIN_KINASE_ST

OBSCN MAP3K3 MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

2.21e-03362937PS00108
DomainMORN

JPH4 JPH2

2.47e-0315932IPR003409
DomainCRYSTALLIN_BETA_GAMMA

CRYBG2 CRYBG3

2.47e-0315932PS50915
DomainMORN

JPH4 JPH2

2.47e-0315932PF02493
DomainCrystall

CRYBG2 CRYBG3

2.47e-0315932PF00030
DomainBeta/gamma_crystallin

CRYBG2 CRYBG3

2.47e-0315932IPR001064
DomainXTALbg

CRYBG2 CRYBG3

2.47e-0315932SM00247
DomainProtein_kinase_ATP_BS

OBSCN SRMS MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

2.85e-03379937IPR017441
DomainPkinase

OBSCN MAP3K3 MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

2.93e-03381937PF00069
DomainProt_kinase_dom

OBSCN SRMS MAP3K3 MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

3.04e-03489938IPR000719
DomainPROTEIN_KINASE_DOM

OBSCN SRMS MAP3K3 MAP3K5 NEK8 MAP3K9 DCLK1 MAP3K2

3.19e-03493938PS50011
DomainG_crystallin-rel

CRYBG2 CRYBG3

3.56e-0318932IPR011024
DomainTSP_1

THSD7A THSD7B C6

3.82e-0363933PF00090
DomainPA

SPPL2B EDEM3

3.97e-0319932PF02225
DomainPA_domain

SPPL2B EDEM3

3.97e-0319932IPR003137
DomainTSP1

THSD7A THSD7B C6

4.18e-0365933SM00209
DomainTSP1_rpt

THSD7A THSD7B C6

4.18e-0365933IPR000884
DomainTSP1

THSD7A THSD7B C6

4.18e-0365933PS50092
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CRYBG2 ARSJ MYCBP2 OBSCN PFAS CLDN3 SPPL2B ITGB4 ABCA7 ACOX3 MAP3K5 DST CANT1 NEK8 TNKS1BP1 WDR90 AGAP3

1.44e-081105991735748872
Pubmed

MAP3Ks as central regulators of cell fate during development.

MAP3K3 MAP3K5 MAP3K9 MAP3K2

8.23e-081599418855897
Pubmed

PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.

MAP3K3 MAP3K5 MAP3K2

2.23e-07599312912994
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

IGSF8 MYCBP2 FKRP NECTIN3 ITGB4 ABCA7 EDEM3 CANT1 KIRREL1 NCEH1 TNKS1BP1 ATM MTDH PIGO

7.84e-061201991435696571
Pubmed

The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.

MAP3K3 MAP3K2

8.02e-06299221333552
Pubmed

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase.

MAP3K3 MAP3K2

8.02e-0629928621389
Pubmed

Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1.

RPS6 ATM

8.02e-06299222451389
Pubmed

Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes.

ITGB4 DST

8.02e-06299231006587
Pubmed

Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.

ATM DCLK1

8.02e-06299227876863
Pubmed

Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men.

RPS6 EIF2B5

2.40e-05399218565837
Pubmed

Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway.

MAP3K5 CTSB

2.40e-05399225713304
Pubmed

Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.

ATM MMP13

2.40e-05399227556690
Pubmed

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.

MAP3K5 MAP3K9

2.40e-05399222197930
Pubmed

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta.

MAP3K3 MAP3K2

2.40e-05399210085062
Pubmed

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.

MAP3K3 MAP3K2

2.40e-05399214681216
Pubmed

Plakophilin 2 affects cell migration by modulating focal adhesion dynamics and integrin protein expression.

ITGB4 PKP2

2.40e-05399223884246
Pubmed

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.

MAP3K3 MAP3K2

2.40e-05399214661019
Pubmed

BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.

ITGB4 DST

4.79e-05499219403692
Pubmed

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

ITGB4 DST

4.79e-05499214668477
Pubmed

MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.

MAP3K3 MAP3K2

4.79e-05499229662197
Pubmed

MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia.

MYCBP2 RCC1

4.79e-05499226304119
Pubmed

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.

MAP3K3 MAP3K2

4.79e-05499211073940
Pubmed

The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression.

ITGB4 DST

4.79e-05499211375975
Pubmed

Structure and function of hemidesmosomes: more than simple adhesion complexes.

ITGB4 DST

7.98e-05599210201522
Pubmed

Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.

MAP3K3 MAP3K2

1.19e-04699219318350
Pubmed

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.

MAP3K3 MAP3K2

1.19e-0469929305638
Pubmed

Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide.

IRF3 MAP3K5

1.19e-04699216670275
Pubmed

Comparison of the human immune response to conjugate and polysaccharide pneumococcal vaccination using a reconstituted SCID mouse model.

IGHV3-49 IGHV3-30

1.19e-04699216860443
Pubmed

PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.

MAP3K3 MAP3K2

1.19e-04699219903815
Pubmed

mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis.

RPS6 MMP13

1.19e-04699224948603
Pubmed

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

SPSB1 ATM

1.67e-04799218449195
Pubmed

14-3-3 proteins interact with specific MEK kinases.

MAP3K3 MAP3K2

1.67e-0479929452471
Pubmed

Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation.

IRF3 ATM

1.67e-04799228930658
Pubmed

Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization.

IGSF8 ITGB4

1.67e-04799216537545
Pubmed

Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system.

GABRB3 GNRH1

1.67e-04799216101898
Pubmed

The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.

ITGB4 DST

1.67e-04799210637308
Pubmed

The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.

MYCBP2 RPS6

1.67e-04799222798074
Pubmed

Genome-wide association study to identify genetic determinants of severe asthma.

ACO1 NDFIP1

1.67e-04799222561531
Pubmed

A single synonymous mutation determines the phosphorylation and stability of the nascent protein.

RPS6 ATM

1.67e-04799230252118
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MYCBP2 MAP3K3 DST MAP3K9 PKP2 TNKS1BP1 CRYBG3 DCLK1 MAP3K2 AGAP3

1.76e-04861991036931259
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

MYCBP2 POLH RCC1 DST LRP2 TNKS1BP1 CRYBG3

1.98e-0441899734709266
Pubmed

Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.

RPS6 RCC1 EIF3D CTSB

2.12e-0410299431722399
Pubmed

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.

MAP3K3 MAP3K2

2.22e-04899215001576
Pubmed

Mechanosensitive mTORC1 signaling maintains lymphatic valves.

RPS6 LYVE1

2.85e-04999237036444
Pubmed

Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling.

RPS6 LYVE1

2.85e-04999228974734
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

ITGB4 DST

2.85e-04999212482924
Pubmed

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.

IRF3 ATM

2.85e-04999216413926
Pubmed

Identification of G protein-coupled receptor genes from the human genome sequence.

ADGRF3 PIGO GPR148

3.11e-044699312044878
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

IRF3 PFAS ITGB4 ADCY3 TSFM CLCN3 EIF2B5 WDR90 CTSB MVK

3.11e-04925991028986522
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

DMGDH GALC ACO1 BCAT2 ACOX3 TSFM SUOX DNAJC11 GHITM ACSF3

3.14e-04926991020877624
Pubmed

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.

RPS6 EIF2B5

3.56e-041099212388085
Pubmed

Expression of olfactory receptors in the cribriform mesenchyme during prenatal development.

ADCY3 GNRH1

3.56e-041099215261832
Pubmed

A microsatellite map of the pink-eyed dilution (p) deletion complex in mouse chromosome 7.

GABRB3 GAS2

3.56e-04109929060416
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

OBSCN RCC1 CTSB MTDH AGAP3

3.77e-0421499522199357
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

RPS6 SRMS RCC1 DST TNKS1BP1 MTDH

3.85e-0433299637433992
Pubmed

A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

MYCBP2 LRP2

4.34e-041199223968836
Pubmed

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

ITGB4 DST

4.34e-04119928707838
Pubmed

Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.

MAP3K3 MAP3K2

4.34e-04119929162092
Pubmed

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.

ITGB4 DST

4.34e-041199210811835
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

ITGB4 DST

4.34e-041199212802069
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

ITGB4 DST

4.34e-041199216757171
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

JPH4 JPH2

5.20e-041299219095005
Pubmed

WNT7B promotes bone formation in part through mTORC1.

RPS6 MMP13

5.20e-041299224497849
Pubmed

Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.

MAP3K3 MAP3K2

5.20e-041299224975362
Pubmed

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.

IRF3 CTSB

5.20e-041299224743339
Pubmed

Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium.

ADCY3 GNRH1

5.20e-041299220573694
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

THSD7A THSD7B DST KATNIP

5.33e-0413099412421765
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYCBP2 RPS6 PFAS PWP1 DST TNKS1BP1 ATM EIF3D

5.66e-0465399822586326
Pubmed

MEKK2 and MEKK3 orchestrate multiple signals to regulate Hippo pathway.

MAP3K3 MAP3K2

6.13e-041399233571521
Pubmed

Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.

ITGB4 DST

6.13e-041399222962592
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

ITGB4 DST

6.13e-04139929670011
Pubmed

Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.

GABRB3 GAS2

6.13e-04139928601493
Pubmed

Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain.

TMC1 LYVE1

7.14e-041499216455951
Pubmed

Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration.

CLDN3 MMP13

7.14e-041499233159885
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

DMGDH GALC ACO1 BCAT2 ACOX3 TSFM SUOX DNAJC11 GHITM ACSF3

8.12e-041047991018614015
Pubmed

Osteoclasts and Macrophages-Their Role in Bone Marrow Cavity Formation During Mouse Embryonic Development.

MMP13 CTSB

8.22e-041599235689447
Pubmed

Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.

MGMT ATM

8.22e-041599220232390
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

FKRP ACO1 NECTIN3 NDFIP1 TMEM177 CANT1 NCEH1 ATM CTSB PIGO

8.98e-041061991033845483
Pubmed

Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation.

RPS6 MMP13

9.38e-041699224218567
Pubmed

Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.

ITGB4 ADCY3

9.38e-041699221067603
Pubmed

Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.

GABRB3 GAS2

9.38e-04169928601494
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

GALC IGHV3-30 MYCBP2 RCC1 PWP1 DST TNKS1BP1 ATM EIF3D MTDH

1.04e-031082991038697112
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

OBSCN SPPL2B ITGB4 ADCY3 MAP3K3 CANT1 LRP2 MAP3K9 MTDH DCLK1

1.06e-031084991011544199
Pubmed

High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies.

GABRB3 JPH4

1.06e-031799221966449
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THSD7A LRP2 CRYBG3

1.11e-037199333541421
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

INPP1 BCAT2 MAP3K3 MAP3K5 ATM

1.18e-0327699528319085
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

IGSF8 OBSCN NECTIN3 KIRREL1

1.21e-0316299425826454
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

OBSCN DNAH2 DST LRP2 MAP3K9 ATM EIF3D C6

1.22e-0373699829676528
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

THSD7A THSD7B C6

1.30e-037599320637190
Pubmed

Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium.

RPS6 ADCY3

1.33e-031999233470495
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

GALC MYCBP2 MAP3K3 NEK8 EIF2B5 KATNIP TNKS1BP1 EIF3D DCLK1 MAP3K2 AGAP3

1.35e-031321991127173435
Pubmed

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

ADCY3 NDFIP1 LYVE1 CANT1 ACSF3 CTSB

1.47e-0343099616303743
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

RPS6 RCC1 NECTIN3 TSFM NDFIP1 CANT1 DNAJC11 KIRREL1 PIGO

1.60e-0395299938569033
Pubmed

Mekk3 is essential for early embryonic cardiovascular development.

MAP3K3 MAP3K2

1.63e-032199210700190
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

MYCBP2 EDEM3 DNAJC11 GHITM PKP2

1.66e-0329899532353859
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

DST DNAJC11 PKP2 KIRREL1 MAP3K2 AGAP3

1.77e-0344699624255178
Pubmed

Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics.

LRP2 MVK

1.79e-032299210438476
Pubmed

Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.

DPYD EEPD1

1.79e-032299221507922
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

CRYBG2 ABCA7 DCLK1

1.80e-038499315203218
Pubmed

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

POLH MGMT ATM

1.80e-038499319237606
Cytoband14q32.33

IGHV3-49 IGHV3-30 TMEM121 IGHV3-30-5 IGHV3-30-3

1.41e-0422899514q32.33
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K3 MAP3K5 MAP3K9 MAP3K2

8.37e-0724564654
GeneFamilyBeta-gamma crystallin domain containing

CRYBG2 CRYBG3

2.82e-0535621360
GeneFamilyImmunoglobulin heavy locus at 14q32.33

IGHV3-49 IGHV3-30 IGHV3-30-5 IGHV3-30-3

2.68e-03187564349
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_1000_k-means-cluster#5

IGSF8 INPP1 SPSB1 THSD7B MAP3K5 SUOX

1.09e-05114936Facebase_RNAseq_e8.5_Paraxial Mesoderm_1000_K5
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_1000_k-means-cluster#1

IGSF8 CLDN3 THSD7B MAP3K5 SUOX FGF11

1.85e-05125936Facebase_RNAseq_e9.5_Facial Mesenchyne_1000_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

IGSF8 JPH4 THSD7B MAP3K5 SUOX LRP2 PKP2 FGF11

6.70e-05311938Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K4
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_500_k-means-cluster#5

IGSF8 CLDN3 THSD7B FGF11

7.95e-0552934Facebase_RNAseq_e9.5_Facial Mesenchyne_500_K5
CoexpressionAtlasFacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000

IGSF8 GABRB3 CRYBG2 JPH4 DNAH2 THSD7B TMEM121 MAP3K5 CLCN3 SUOX DNAJC11 SPACA6 LRP2 FGF11

8.58e-059769314Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000
CoexpressionAtlasFacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#1

JPH4 CLCN3 LRP2 PKP2 FGF11

1.18e-04109935Facebase_RNAseq_e9.5_Olfactory Placode_1000_K1
CoexpressionAtlaskidney_adult_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

GABRB3 DPYD ACO1 GAS2 JPH2 MFSD4A ACOX3 MAP3K5 SUOX LRP2 NCEH1 CTSB

1.89e-047999312gudmap_kidney_adult_JuxtaGlom_Ren1_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_500_k-means-cluster#5

IGSF8 THSD7B MAP3K5 SUOX

1.90e-0465934Facebase_RNAseq_e8.5_Paraxial Mesoderm_500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#3

IGSF8 INPP1 IRF3 THSD7B MAP3K5 SUOX CTSB

2.17e-04277937Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K3
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#2

IGSF8 IRF3 THSD7B MAP3K5 SUOX FGF11 CTSB

2.37e-04281937Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_2500_K2
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#5

IGSF8 THSD7B MAP3K5 SUOX CTSB

2.50e-04128935Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_1000_K5
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_500

IGSF8 JPH4 INPP1 CLDN3 THSD7B DNAJC11 SPACA6 FGF11 CTSB

2.81e-04486939Facebase_RNAseq_e9.5_Facial Mesenchyne_500
CoexpressionAtlasFacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000

IGSF8 JPH4 DNAH2 CLDN3 THSD7B MAP3K5 CLCN3 SUOX DNAJC11 SPACA6 LRP2 PKP2 FGF11

3.14e-049739313Facebase_RNAseq_e9.5_Olfactory Placode_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_top-relative-expression-ranked_500

GALC MYCBP2 CLDN3 MAP3K5 DST CLCN3 LRP2 PKP2

3.37e-04394938gudmap_developingLowerUrinaryTract_e15.5_urothelium_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000

IGSF8 CRYBG2 JPH4 POLH DNAH2 CLDN3 THSD7B MAP3K5 SUOX SPACA6 LRP2 PKP2 FGF11

3.50e-049849313Facebase_RNAseq_e10.5_Olfactory Pit_1000
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARSJ THSD7A OBSCN ITGB4 LYVE1 DST ANKRD2

9.37e-08170977af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARSJ THSD7A OBSCN ITGB4 LYVE1 DST ANKRD2

1.02e-071729779a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD ACO1 CLDN3 EEPD1 PKP2

3.03e-06183976d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

THSD7A RPS6 ITGB4 LYVE1 DST CTSB

4.12e-061939765f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CRYBG2 FKRP SPSB1 SUOX GPANK1

2.34e-0515697584f01419d8c116714e8c8c857c4d153a755b7867
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-fibrocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC1 THSD7B ABCA7 DNAAF3 CD163L1

2.34e-051569755b56217336771baf57d791efcb4e206c6aea83b1
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CRYBG2 FKRP SPSB1 SUOX GPANK1

2.34e-051569752285be9746d0d0f62a488b9c64fa67a834758dd7
ToppCellControl-B_naive-12|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

DMGDH GALC PFAS DST CRYBG3

2.49e-0515897541318f864770370ce77ed3fa4a84f76c0c22c482
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

CRYBG2 INPP1 MFSD4A TNKS1BP1 MMP13

3.63e-05171975adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages|bone_marrow / Manually curated celltypes from each tissue

LYVE1 DST NCEH1 HAS1 CTSB

3.95e-051749750746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

PFAS DST CLCN3 NEK8 MAP3K2

3.95e-051749752274648b80dd74f3c948a779bba3391095964c34
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A THSD7B CD163L1 PKP2 KIRREL1

4.06e-05175975e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ARSJ THSD7A OBSCN LYVE1 DST

4.40e-051789750139b42494c1186390b12106dea7957e2b6717c2
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-8|TCGA-Kidney / Sample_Type by Project: Shred V9

BCAT2 TSFM TMEM177 ACSF3 CTSB

4.52e-051799758c6a84602b079bd357c66244371eb23dd9384918
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A GAS2 TMEM121 KIRREL1 NCEH1

4.52e-05179975c7c74e26bbf86c5326ee38bac7de111d5414f46b
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF8 POLH RCC1 NECTIN3 TMEM121

4.76e-05181975145fae2746c5212640b7b11b04a7759ba8e5c322
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF8 POLH RCC1 NECTIN3 TMEM121

4.76e-05181975a9f1fc5973cffdbeb7d1f5c41534422d85d596ff
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD CLDN3 NECTIN3 PKP2

4.89e-05182975770ce9f3f4538d0181a0181543841bc964c68274
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARSJ THSD7A ITGB4 LYVE1 DST

4.89e-05182975ebc812ed3f25839ea25f76b952c463d79a8325b1
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD CLDN3 NECTIN3 PKP2

4.89e-0518297577ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH DPYD CLDN3 NECTIN3 PKP2

4.89e-051829754921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARSJ THSD7A ITGB4 LYVE1 DST

4.89e-0518297547ff6b4002a4167412c79210651316d1342503f9
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A ITGB4 LYVE1 DST SPACA6

5.02e-0518397512e876d6205af8aad74265c668b5e95b9e7487f3
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SPSB1 PAQR4 JPH2 EEPD1 DCLK1

5.02e-05183975e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RENBP F10 DST NCEH1 CTSB

5.15e-05184975fe9ea4d0e0be820e95eaf9bb42a5560d0e177574
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARSJ THSD7A ITGB4 LYVE1 DST

5.15e-05184975f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARSJ THSD7A ITGB4 LYVE1 DST

5.15e-051849758bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A THSD7B CD163L1 PKP2 KIRREL1

5.15e-0518497532473dbdb2de66391157c5814ef34e790806e4f2
ToppCellCOVID-19-Heart-CM_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

GAS2 OBSCN JPH2 ANKRD2 PKP2

5.15e-05184975e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARSJ THSD7A EDEM3 DST NEK8

5.28e-0518597587151ab95530e70d61328b336518df58db584acb
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

GAS2 OBSCN ANKRD2 PKP2 NCEH1

5.28e-051859756baccb26f999145e51b91d94315bf8d4655bef31
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RENBP F10 DST NCEH1 CTSB

5.42e-051869757950e03ea080238c168b9d807e217f459acdfb28
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARSJ THSD7A ITGB4 LYVE1 DST

5.42e-051869755302399825f213d105ac70b91366a4513b732838
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

GAS2 OBSCN JPH2 PKP2 NCEH1

5.56e-0518797578cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A THSD7B CD163L1 PKP2 KIRREL1

5.70e-051889756ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

THSD7A RPS6 LYVE1 DST CTSB

5.70e-0518897550b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

GAS2 OBSCN ANKRD2 PKP2 NCEH1

5.70e-051889750758b474457efa36488e0195f7357100f4b6a090
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

THSD7A ITGB4 LYVE1 DST CTSB

5.70e-05188975263169029293e005bcffd87db20221fdd2d3917e
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

GAS2 OBSCN JPH2 PKP2 NCEH1

5.85e-051899759c1debd65c13d63fd4f3158917d621b44b714c26
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYD JPH2 TMEM121 WSCD2 INPP5J

5.85e-051899754dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYD JPH2 TMEM121 WSCD2 INPP5J

5.85e-051899750d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellCF-Lymphoid-B_cell|CF / Disease state, Lineage and Cell class

MYCBP2 PWP1 FCRL1 MGMT ATM

5.99e-05190975374d8fd63c733178acab07682ed1519693efab45
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ARSJ THSD7A ITGB4 LYVE1 DST

5.99e-05190975e1b721bb74561fe51c53328a0394c9954e489049
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

ACO1 FCRL1 DST PKP2 NCEH1

5.99e-051909752592765016f291565697265800a232b2edef3792
ToppCellP03-Endothelial-large_vessel_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

THSD7A RPS6 ITGB4 LYVE1 DST

6.15e-05191975b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RENBP LYVE1 CD163L1 EEPD1 CTSB

6.46e-051939752d0dd2671ff27b922eb316f1ed0140353536ef30
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARSJ THSD7A ITGB4 LYVE1 DST

6.46e-0519397558c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SPSB1 MAP3K5 DST EEPD1 DCLK1

6.61e-0519497590efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SPSB1 MAP3K5 DST EEPD1 DCLK1

6.61e-05194975df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

DPYD LYVE1 CD163L1 EEPD1 CTSB

6.78e-05195975c172c5599379c29123340621a36bfb1fc90c2115
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARSJ SPSB1 ANKRD2 HAS1 DCLK1

7.28e-051989752dc0510846cbc296a300b8465e7be9b39f479852
ToppCellParenchyma_Control_(B.)-Stromal-TX-Mesothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ARSJ SPSB1 ANKRD2 HAS1 DCLK1

7.28e-05198975eb7e674d08a7aeb554c1e4797338280581b79989
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ARSJ SPSB1 ANKRD2 HAS1 DCLK1

7.28e-05198975364de83e30d842123fb92367f54b4bea57a47c84
ToppCellSevere_COVID-19-Myeloid-MoAM4|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

RENBP EEPD1 NCEH1 CTSB AGAP3

7.64e-0520097530448a41ca64d6f0fedaff0b7a6670dd33cdf2c5
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RENBP EEPD1 NCEH1 CTSB AGAP3

7.64e-052009754f481d87e30195365900acb5d50641a9e7b2f462
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RENBP EEPD1 NCEH1 CTSB AGAP3

7.64e-052009755490393c5f54748f912676e19b58bd1320415a06
ToppCellBiopsy_Other_PF-Mesenchymal-PLIN2+_Fibroblasts|Biopsy_Other_PF / Sample group, Lineage and Cell type

ARSJ SPSB1 F10 HAS1 DCLK1

7.64e-052009750aa316b71f195ecf17ee897e307f8928a755a637
ToppCellNeuronal-Inhibitory-iA|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A THSD7B EEPD1 PKP2 KIRREL1

7.64e-052009755ef4a3dc18a44292184a59ced916183c0699b01e
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RENBP EEPD1 NCEH1 CTSB AGAP3

7.64e-05200975cf720d3973e79ffd4c6e763a7284799ced22a274
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RENBP EEPD1 NCEH1 CTSB AGAP3

7.64e-05200975df821ac12953e44fcfedbbefb35a4976e406ccd6
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

INPP1 PAQR4 NEK8 ACSF3

1.29e-0411897408bdf7bc3c9dcbc0f690658fe14e6cc4b9581698
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

INPP1 PAQR4 NEK8 ACSF3

1.29e-041189743b077ad5c68c01b3fcc93f203cb130bb90705af9
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPYD DNAH2 NDFIP1 ATM

1.51e-04123974511b7c20a4a85e49980936d52af7dbca19bb848e
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

IGSF8 ADCY3 MAP3K3 GNRH1

1.93e-0413197488b3298110bc2333ffa202a3f41ac0d24e2308c7
ToppCellBasal|World / shred by cell class for bronchial biopsy

RPS6 BCAT2 ITGB4 DST

2.04e-04133974d8dd6d0fea5b2c0b1b60b648fa96524027b36e25
ToppCelldroplet-Heart-4Chambers-18m-Hematologic-erythrocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM177 GHITM WDR90

2.48e-045697364bb7d3632b14452b6b861f73880b1dab729a0cf
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf|Cerebellum / BrainAtlas - Mouse McCarroll V32

CRYBG2 THSD7B GNRH1

3.51e-046397383e1c91f830aadaf13e13254ce30189fd434bcc9
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

CRYBG2 THSD7B GNRH1

3.51e-0463973f2532b1aa117eea550f0ae0b599780c4fe621407
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1|Cerebellum / BrainAtlas - Mouse McCarroll V32

CRYBG2 THSD7B GNRH1

3.51e-04639730643435edf3280daf38c950e5bec287a9d5cb517
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)|Cerebellum / BrainAtlas - Mouse McCarroll V32

CRYBG2 THSD7B GNRH1

3.51e-046397371c3afda6534401320791b714e3e2fe83094c914
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

LYVE1 DST CD163L1 NCEH1

3.75e-041569749a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellControl-B_naive-12|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

DMGDH GALC DST CRYBG3

3.84e-041579744803f601c1ba43260aa09172acc7964aac2c8ccf
ToppCellClub_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

THSD7A MFSD4A BCAT2 ADGRF3

4.13e-04160974b261a3a49c850d92bc9e04fc3527c752dfe37a1a
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MFSD4A ABCA7 DST DCLK1

4.13e-0416097458ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SPSB1 OBSCN THSD7B MAP3K5

4.32e-0416297458da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SPSB1 OBSCN THSD7B MAP3K5

4.32e-041629744d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PAQR4 JPH2 LYVE1 GNRH1

4.43e-041639748f24cef152f5965727bbeee116bd26c75cbba82a
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALC ADCY3 AJM1 C6

4.43e-041639748dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SPSB1 OBSCN THSD7B MAP3K5

4.43e-04163974b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3|TCGA-Uterus / Sample_Type by Project: Shred V9

MFSD4A NDFIP1 DST MMP13

4.43e-04163974d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALC ADCY3 AJM1 C6

4.43e-04163974fd243ca223079033be480a24817a399f281fa4d4
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MYCBP2 THSD7B F10 CRYBG3

4.53e-041649744d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCellBasal_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

BCAT2 THSD7B ITGB4 MMP13

4.53e-0416497485487a303194f5244956ec1ca2d1758d38117f41
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-7|TCGA-Kidney / Sample_Type by Project: Shred V9

CLDN3 DNAAF3 NEK8 KATNIP

4.74e-04166974b545de32578047c9ca422354b8992f2d9c9e1cc7
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

MAP3K9 FGF11 NYAP1 INPP5J

4.85e-041679749efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

MAP3K9 FGF11 NYAP1 INPP5J

4.85e-04167974904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOWAHD BCAT2 F10 AJM1

5.07e-041699741558606be0a8bcd4fd0ce609701a1411e4ca2f9f
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOWAHD BCAT2 F10 AJM1

5.07e-041699741b2354de1ce4080118d9f01e7c5fd6079e705125
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANKRD2 PKP2 FGF11 DCLK1

5.07e-04169974559e98216720e4babf0b0941100f1b485c35b11b
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

OBSCN JPH2 ANKRD2 PKP2

5.19e-041709743f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

OBSCN LYVE1 CD163L1 CTSB

5.19e-041709744232fe937909f93d3736988c707b8f95ce993398
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFSD4A THSD7B ITGB4 LYVE1

5.30e-04171974686f95892c3909973c66c9a27159a070a068f175
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFSD4A THSD7B ITGB4 LYVE1

5.30e-04171974f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCelldroplet-Kidney-nan-21m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH CLDN3 LRP2 NCEH1

5.30e-04171974007f148f4611ea1826edfa9f91ced36541ad9f5a
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A THSD7B PKP2 KIRREL1

5.30e-04171974a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCellPND14-Endothelial-Endothelial_lymphatic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFSD4A THSD7B ITGB4 LYVE1

5.30e-04171974d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH CLDN3 LRP2 NCEH1

5.30e-041719748e7223ba447947cdf4e1c82a52fd90439cf3d8f6
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFSD4A THSD7B ITGB4 LYVE1

5.30e-04171974fbf8e9db00573adcada4b25730e191417b7c9999
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

MAP3K5 LRP2 WSCD2 KIRREL1

5.42e-0417297436a96714a0eb6ac438648135336c9791881ddadb
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYD DST C6 MMP13

5.42e-041729747295bf3ae21a61dd6bcfa0dfb7a37d0f3e8f94ab
DiseaseEpidermolysis Bullosa Simplex

ITGB4 DST

9.56e-055922C0079298
Diseasemental or behavioural disorder, substance abuse

PWP1 MGMT

1.43e-046922EFO_0000677, MONDO_0002491
DiseaseCD5 antigen-like measurement

FCRL1 KIRREL1

2.00e-047922EFO_0020248
Diseasefemale breast cancer (is_implicated_in)

POLH ATM

2.66e-048922DOID:0050671 (is_implicated_in)
DiseaseGastric Adenocarcinoma

MAP3K9 ATM DCLK1

3.79e-0445923C0278701
DiseaseCardiomyopathy, Dilated

RENBP PKP2 ATM

4.58e-0448923C0007193
DiseaseMachado-Joseph disease, age at onset

INPP1 THSD7B

5.19e-0411922EFO_0004847, MONDO_0007182
Diseasesmoking behaviour measurement, waist-hip ratio

BCAT2 MGMT

5.19e-0411922EFO_0004343, EFO_0005671
Diseaseeye colour measurement

MYCBP2 NECTIN3 FCRL1 MGMT LRP2

6.14e-04218925EFO_0009764
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

MAP3K5 LRP2

8.54e-0414922DOID:10976 (biomarker_via_orthology)
DiseaseChildhood Ataxia with Central Nervous System Hypomyelinization

DPYD EIF2B5

8.54e-0414922C1858991
Diseasethalamus volume change measurement

TMC1 SPSB1

8.54e-0414922EFO_0021496
Diseasebreast cancer (is_implicated_in)

F10 MGMT ATM GNRH1

1.27e-03150924DOID:1612 (is_implicated_in)
Diseaseanorexia nervosa

THSD7A MGMT LRP2

1.38e-0370923MONDO_0005351
Diseasebrain age measurement

DMGDH GALC

1.76e-0320922EFO_0010602
DiseaseDisease Exacerbation

RPS6 ABCA7 CLCN3 CTSB

1.80e-03165924C0235874
DiseaseHereditary Diffuse Gastric Cancer

DPYD RPS6 CLDN3 CLCN3 ATM

2.27e-03293925C1708349
DiseaseSensorineural Hearing Loss (disorder)

TMC1 LRP2

2.33e-0323922C0018784
DiseaseStomach Neoplasms

DPYD RPS6 CLDN3 CLCN3 ATM

2.41e-03297925C0038356
DiseaseMalignant neoplasm of stomach

DPYD RPS6 CLDN3 CLCN3 ATM

2.51e-03300925C0024623
DiseaseGlioma

CLCN3 MGMT ATM

2.57e-0387923C0017638
Diseaseresponse to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema

THSD7A DCLK1

2.98e-0326922EFO_0005325, EFO_0005532, EFO_0010735

Protein segments in the cluster

PeptideGeneStartEntry
GKEYGAGSSRDWAAK

ACO1

771

P21399
LANSVWEGALGGYSK

AGAP3

701

Q96P47
YLREGECWLDGKGGA

ADGRF3

911

Q8IZF5
FWTRKGLVSGGLYES

CTSB

161

P07858
KSGLWIAYEGSNFLG

CRYBG3

2791

Q68DQ2
GRADGELYKNLWGAV

ACOX3

656

O15254
KGRAGEGLGRNWYVT

AJM1

516

C9J069
WPAVGIAKRTTYGGV

DPYD

751

Q12882
GDTVVFKDGQYWIRG

ACSF3

456

Q4G176
GGKYIGERSVRVWGH

CD163L1

951

Q9NR16
QKGAGYAGFLWDAAA

EEPD1

346

Q7L9B9
KKWVNEVRYGGFSLG

ABCA7

1406

Q8IZY2
VGYAVTKDGRVFAWG

RCC1

356

P18754
GEWFGYLSREGKVAL

RENBP

366

P51606
RVTSAKGWGELEFGA

DNAJC11

201

Q9NVH1
AGVDRWANKGGLIAY

INPP1

361

P49441
EGYWSQGKRHGLGIE

JPH2

61

Q9BR39
GKGLEWVAVISYDGS

IGHV3-30-5

61

P0DP03
SYGWVGDGFVVISRI

LYVE1

86

Q9Y5Y7
GAAVSYLLGRGAAWV

GPANK1

156

O95872
PKDGAGTRVSYAFWI

MFSD4A

211

Q8N468
IRAAWYTAGIVGGLS

GHITM

216

Q9H3K2
GKGLEWVAVISYDGS

IGHV3-30-3

61

P0DP02
SGSWRGRKEEYVTGQ

DST

2551

Q03001
IKSTWGDRHYVGLNG

KATNIP

981

O60303
LRGSKGTYWEGGIRA

ARSJ

341

Q5FYB0
GNYSGGLAVKEWLLA

MGMT

156

P16455
WVRKDSGVGAGIDSY

EDEM3

281

Q9BZQ6
VSGLRYAGLWKDGFQ

JPH4

101

Q96JJ6
ETGYGLKVDIWAAGV

DCLK1

561

O15075
WLAVKDERLYVGGLG

CANT1

216

Q8WVQ1
GLAISKDFWGTVGYR

C9orf131

361

Q5VYM1
AEVGAAGKGYLWKAA

EIF2B5

486

Q13144
RAAWVKVPSGFYVGS

TSFM

201

P43897
GRKFWALNGYDILEG

MMP13

351

P45452
KRSVVYIHGGGWALA

NCEH1

106

Q6PIU2
YIHGGGWALASAKIR

NCEH1

111

Q6PIU2
EVISGEGYGRKADIW

MAP3K2

531

Q9Y2U5
VAIGAESEVYSWGKG

NEK8

626

Q86SG6
ESEVYSWGKGARGRL

NEK8

631

Q86SG6
FYWRGGDKAVTGVER

GABRB3

191

P28472
GVRGIAVDWVAGNLY

LRP2

2146

P98164
GKGLEWVGFIRSKAY

IGHV3-49

61

A0A0A0MS15
WVGFIRSKAYGGTTE

IGHV3-49

66

A0A0A0MS15
VSGSDAAGYFRVWKV

H1-7

111

Q75WM6
YTVKARNGAGWGPER

ITGB4

1296

P16144
VGYTVLSGVAGWRAL

PAQR4

151

Q8N4S7
RSGRAWYLGLDKEGQ

FGF11

166

Q92914
GYRVEVKEGATGQWR

OBSCN

4556

Q5VST9
RYGAISGFGLSLIKW

NDFIP1

146

Q9BT67
GLGGAWAFVLRDVIY

ATM

1456

Q13315
SWAGVGALAYKAPEA

ANKRD2

6

Q9GZV1
LEAVAWLAGGTVYRG

IGSF8

441

Q969P0
ERVAARGYWGDIATG

DNAAF3

266

Q8N9W5
GGRSEYGAALAWEKG

C6

446

P13671
YGAALAWEKGSSGLE

C6

451

P13671
GDITFLWYKGAVGLN

FCRL1

141

Q96LA6
GDRLGKVADWTGATY

EIF3D

36

O15371
RIYAEAKTSGIWGQG

GPR148

241

Q8TDV2
AKTSGIWGQGYSRAR

GPR148

246

Q8TDV2
VKAAWGKVGAHAGEY

HBA1;

11

P69905
VKGGRGYDRDHVVLW

CRYBG2

1631

Q8N1P7
AGVIGARKPHYDIWG

ADCY3

1051

O60266
GKGLEWVAVISYDGS

IGHV3-30

61

P01768
SGWGTSGRRKLAANY

HAS1

486

Q92839
IIHAGGVGKYLSDWI

DMGDH

401

Q9UI17
LLGYGWAAACAGARK

MTDH

66

Q86UE4
EILGYRWAKGGFLIE

KIRREL1

251

Q96J84
GVLEAAGVRYWLEGG

FKRP

331

Q9H9S5
WSYGLRPGGKRDAEN

GNRH1

26

P01148
IVSWGEGCARKGKYG

F10

436

P00742
AFIRAWVGGVGNYKL

BCAT2

216

O15382
RVTGDLAGWIIYALG

GALC

606

P54803
KDGVWVRGLYLEGAG

DNAH2

4326

Q9P225
ITYSWKFAGGGLRTQ

SPACA6

181

W5XKT8
GKVYRAFWIGDEVAV

MAP3K9

156

P80192
GEGYGRKADVWSLGC

MAP3K3

541

Q99759
AWAEATGAYVPGRDK

IRF3

56

Q14653
TFGAGWALQRKVLYG

NYAP1

626

Q6ZVC0
RGYGKAADIWSLGCT

MAP3K5

856

Q99683
RVGGGWETFAGYLLK

GAS2

251

O43903
LGEEWKGYVVRISGG

RPS6

41

P62753
DGRLKTWVYGVAAGA

THSD7A

1601

Q9UPZ6
KYGRKATWIGASGDQ

MYCBP2

1046

O75592
SWKGGGIIAVSYEAR

POLH

41

Q9Y253
TGSLGRYWGKAAAAA

SOWAHD

36

A6NJG2
ALGRKLGEGYFGEVW

SRMS

231

Q9H3Y6
LGGSGYLIFWAVKRS

TMC1

376

Q8TDI8
KREMGAGLYVGWAAA

CLDN3

156

O15551
TSKWVGDAFGREGIY

CLCN3

616

P51790
YWGNKGGVSVRLAAF

INPP5J

536

Q15735
YAFGGQKEGLRVWDI

PWP1

446

Q13610
GWLRLKAVVGYSGNG

WDR90

1106

Q96KV7
AIRGKVGYTRGLHVW

SPSB1

86

Q96BD6
AVSTWGGALRYHQGK

MVK

206

Q03426
GFSYADVLGSAKGWA

PFAS

1116

O15067
VWVGAEVRTAKRGYA

TMEM121

61

Q9BTD3
VAIGGYWAGSRDVKK

SPPL2B

186

Q8TCT7
EFGKSAWIRDYSSGG

TNKS1BP1

951

Q9C0C2
VGGRAKNLWYGACVA

PIGO

661

Q8TEQ8
KGYAWSGGGRAVIRV

SUOX

446

P51687
RAKLGDYGGAWSRAL

WSCD2

101

Q2TBF2
DYGGAWSRALKGRVV

WSCD2

106

Q2TBF2
DGRVKIWVYGVSGGA

THSD7B

1551

Q9C0I4
WALGVGAKYTLGLHA

TMEM177

181

Q53S58
LKAGTTATYEGRWGR

PKP2

111

Q99959
VSVTGYDGNWFVGRK

NECTIN3

271

Q9NQS3