Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ligase activity	AARS1 CAD ACSM1 ACSS2 VARS1 DPH6	4.56e-05	174	74	6	GO:0016874
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B7 UGT2B28 UGT2B11	2.35e-06	8	73	3	GO:0070980
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B7 UGT2B28 UGT2B11	5.01e-06	10	73	3	GO:0018879
GeneOntologyBiologicalProcess	benzene-containing compound metabolic process	ACSM1 UGT2B7 UGT2B28 UGT2B11	8.73e-06	37	73	4	GO:0042537
GeneOntologyBiologicalProcess	organophosphate metabolic process	FCSK FASN CAD PDE4D PIK3C3 PLCH2 ACSM1 DOLK FLCN NR1H2 ABCD1 ACSS2 ABCC6 GFPT1 MMUT	9.03e-06	1142	73	15	GO:0019637
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT2B7 UGT2B28 UGT2B11	9.15e-06	12	73	3	GO:0052697
GeneOntologyBiologicalProcess	short-chain fatty acid metabolic process	ACSM1 ACSS2 MMUT	3.34e-05	18	73	3	GO:0046459
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	FASN ACSM1 ABCD1 ACSS2 MMUT	4.24e-05	109	73	5	GO:0006637
GeneOntologyBiologicalProcess	thioester metabolic process	FASN ACSM1 ABCD1 ACSS2 MMUT	4.24e-05	109	73	5	GO:0035383
GeneOntologyBiologicalProcess	monocarboxylic acid metabolic process	FASN ACSM1 UGT2B7 FLCN NR1H2 ABCD1 HADH UGT2B28 ACSS2 UGT2B11 MMUT	4.94e-05	731	73	11	GO:0032787
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT2B7 UGT2B28 UGT2B11	5.40e-05	21	73	3	GO:0052695
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	FASN CAD ACSM1 UGT2B7 FLCN NR1H2 ABCD1 HADH UGT2B28 ACSS2 UGT2B11 GFPT1 MMUT	6.19e-05	1035	73	13	GO:0019752
GeneOntologyBiologicalProcess	nucleobase-containing small molecule metabolic process	FCSK FASN CAD PDE4D ACSM1 FLCN ABCD1 ACSS2 ABCC6 GFPT1 MMUT	7.60e-05	767	73	11	GO:0055086
GeneOntologyBiologicalProcess	oxoacid metabolic process	FASN CAD ACSM1 UGT2B7 FLCN NR1H2 ABCD1 HADH UGT2B28 ACSS2 UGT2B11 GFPT1 MMUT	7.74e-05	1058	73	13	GO:0043436
GeneOntologyBiologicalProcess	organic acid metabolic process	FASN CAD ACSM1 UGT2B7 FLCN NR1H2 ABCD1 HADH UGT2B28 ACSS2 UGT2B11 GFPT1 MMUT	8.20e-05	1064	73	13	GO:0006082
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT2B7 UGT2B28 UGT2B11	1.04e-04	26	73	3	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT2B7 UGT2B28 UGT2B11	1.04e-04	26	73	3	GO:0006063
GeneOntologyBiologicalProcess	ribonucleotide metabolic process	FASN CAD PDE4D ACSM1 FLCN ABCD1 ACSS2 ABCC6 MMUT	1.07e-04	533	73	9	GO:0009259
GeneOntologyBiologicalProcess	ribose phosphate metabolic process	FASN CAD PDE4D ACSM1 FLCN ABCD1 ACSS2 ABCC6 MMUT	1.18e-04	540	73	9	GO:0019693
GeneOntologyBiologicalProcess	propionate metabolic process	ACSS2 MMUT	1.23e-04	5	73	2	GO:0019541
GeneOntologyBiologicalProcess	positive regulation of macrophage fusion	ADAM9 OCSTAMP	1.23e-04	5	73	2	GO:0034241
GeneOntologyBiologicalProcess	nucleotide metabolic process	FCSK FASN CAD PDE4D ACSM1 FLCN ABCD1 ACSS2 ABCC6 MMUT	1.42e-04	684	73	10	GO:0009117
GeneOntologyBiologicalProcess	xenobiotic metabolic process	CAD ACSM1 UGT2B7 UGT2B28 UGT2B11	1.44e-04	141	73	5	GO:0006805
GeneOntologyBiologicalProcess	nucleoside bisphosphate metabolic process	FASN ACSM1 ABCD1 ACSS2 MMUT	1.49e-04	142	73	5	GO:0033865
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate metabolic process	FASN ACSM1 ABCD1 ACSS2 MMUT	1.49e-04	142	73	5	GO:0033875
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate metabolic process	FASN ACSM1 ABCD1 ACSS2 MMUT	1.49e-04	142	73	5	GO:0034032
GeneOntologyBiologicalProcess	nucleoside phosphate metabolic process	FCSK FASN CAD PDE4D ACSM1 FLCN ABCD1 ACSS2 ABCC6 MMUT	1.54e-04	691	73	10	GO:0006753
GeneOntologyBiologicalProcess	regulation of macrophage fusion	ADAM9 OCSTAMP	1.84e-04	6	73	2	GO:0034239
GeneOntologyBiologicalProcess	xenobiotic catabolic process	UGT2B7 UGT2B28 UGT2B11	3.03e-04	37	73	3	GO:0042178
GeneOntologyBiologicalProcess	androgen metabolic process	UGT2B7 UGT2B28 UGT2B11	3.28e-04	38	73	3	GO:0008209
GeneOntologyBiologicalProcess	carbohydrate derivative metabolic process	FCSK FASN CAD PDE4D ACSM1 DOLK FLCN ABCD1 ACSS2 TET3 ABCC6 GFPT1 MMUT	3.32e-04	1226	73	13	GO:1901135
GeneOntologyBiologicalProcess	macrophage fusion	ADAM9 OCSTAMP	3.41e-04	8	73	2	GO:0034238
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	3.41e-04	8	73	2	GO:2000427
GeneOntologyBiologicalProcess	purine ribonucleotide metabolic process	FASN PDE4D ACSM1 FLCN ABCD1 ACSS2 ABCC6 MMUT	4.46e-04	512	73	8	GO:0009150
GeneOntologyBiologicalProcess	response to xenobiotic stimulus	CAD ACSM1 UGT2B7 HADH UGT2B28 XRCC5 UGT2B11 ABCC6	5.26e-04	525	73	8	GO:0009410
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	5.46e-04	10	73	2	GO:2000425
GeneOntologyBiologicalProcess	fatty acid biosynthetic process	FASN ACSM1 NR1H2 ABCD1 ACSS2	5.83e-04	191	73	5	GO:0006633
GeneOntologyBiologicalProcess	estrogen metabolic process	UGT2B7 UGT2B28 UGT2B11	8.30e-04	52	73	3	GO:0008210
GeneOntologyBiologicalProcess	aminoacyl-tRNA metabolism involved in translational fidelity	AARS1 VARS1	9.40e-04	13	73	2	GO:0106074
GeneOntologyCellularComponent	nuclear outer membrane	BOK UGT2B7 UGT2B28 UGT2B11	1.20e-05	40	74	4	GO:0005640
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	3.41e-04	8	74	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	4.38e-04	9	74	2	GO:0044217
Domain	UDPGT	UGT2B7 UGT2B28 UGT2B11	6.95e-05	21	72	3	PF00201
Domain	UDPGT	UGT2B7 UGT2B28 UGT2B11	6.95e-05	21	72	3	PS00375
Domain	UDP_glucos_trans	UGT2B7 UGT2B28 UGT2B11	6.95e-05	21	72	3	IPR002213
Domain	Anaphylatoxin_comp_syst	C4A C4B	1.45e-04	5	72	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	1.45e-04	5	72	2	IPR001840
Domain	ABC_TM1F	ABCB7 ABCD1 ABCC6	1.68e-04	28	72	3	PS50929
Domain	ABC1_TM_dom	ABCB7 ABCD1 ABCC6	1.68e-04	28	72	3	IPR011527
Domain	ANATO	C4A C4B	3.04e-04	7	72	2	SM00104
Domain	ANATO	C4A C4B	3.04e-04	7	72	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	3.04e-04	7	72	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	3.04e-04	7	72	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	3.04e-04	7	72	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	4.04e-04	8	72	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	4.04e-04	8	72	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	4.04e-04	8	72	2	IPR019742
Domain	ABC_transporter_CS	ABCB7 ABCD1 ABCC6	5.66e-04	42	72	3	IPR017871
Domain	A2M_N	C4A C4B	6.46e-04	10	72	2	PF01835
Domain	A2M_N	C4A C4B	6.46e-04	10	72	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	6.46e-04	10	72	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	6.46e-04	10	72	2	PS00477
Domain	A2M	C4A C4B	6.46e-04	10	72	2	PF00207
Domain	A2M_N_2	C4A C4B	6.46e-04	10	72	2	IPR011625
Domain	A2M_comp	C4A C4B	6.46e-04	10	72	2	IPR011626
Domain	A2M_N_2	C4A C4B	6.46e-04	10	72	2	PF07703
Domain	A2M_recep	C4A C4B	6.46e-04	10	72	2	PF07677
Domain	A2M_comp	C4A C4B	6.46e-04	10	72	2	PF07678
Domain	Macroglobln_a2	C4A C4B	6.46e-04	10	72	2	IPR001599
Domain	ABC_tran	ABCB7 ABCD1 ABCC6	8.39e-04	48	72	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCB7 ABCD1 ABCC6	8.39e-04	48	72	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCB7 ABCD1 ABCC6	8.91e-04	49	72	3	PS00211
Domain	ABC_transporter-like	ABCB7 ABCD1 ABCC6	9.45e-04	50	72	3	IPR003439
Domain	EGF_extracell	TENM4 ADAM9 TNR	1.61e-03	60	72	3	IPR013111
Domain	EGF_2	TENM4 ADAM9 TNR	1.61e-03	60	72	3	PF07974
Domain	C345C	C4A C4B	1.92e-03	17	72	2	SM00643
Domain	AMP-bd_C	ACSM1 ACSS2	1.92e-03	17	72	2	IPR025110
Domain	AMP-binding_C	ACSM1 ACSS2	1.92e-03	17	72	2	PF13193
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	2.15e-03	18	72	2	IPR008930
Domain	NTR	C4A C4B	2.40e-03	19	72	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	2.40e-03	19	72	2	IPR018933
Domain	NTR	C4A C4B	3.52e-03	23	72	2	PS50189
Domain	Netrin_domain	C4A C4B	3.52e-03	23	72	2	IPR001134
Domain	Metal_Hydrolase	TATDN3 CAD	3.83e-03	24	72	2	IPR032466
Domain	ABC_membrane	ABCB7 ABCC6	3.83e-03	24	72	2	PF00664
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	SLC26A2 ACSM1 UGT2B7 UGT2B28 UGT2B11	8.99e-05	107	60	5	MM14595
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	SLC26A2 ACSM1 UGT2B7 UGT2B28 UGT2B11	9.81e-05	109	60	5	M18788
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	FASN HADH ACSS2	1.07e-04	22	60	3	M39440
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	FASN HADH ACSS2	1.22e-04	23	60	3	MM15885
Pathway	REACTOME_PREDNISONE_ADME	UGT2B7 UGT2B28 UGT2B11	1.22e-04	23	60	3	MM16639
Pathway	REACTOME_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	1.39e-04	24	60	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	1.58e-04	25	60	3	M17787
Pathway	WP_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	1.58e-04	25	60	3	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT2B7 UGT2B28 UGT2B11	1.58e-04	25	60	3	M605
Pathway	WP_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	1.78e-04	26	60	3	M39404
Pathway	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	UGT2B7 UGT2B28 UGT2B11	2.23e-04	28	60	3	M19580
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	SLC26A2 ACSM1 UGT2B7 UGT2B28 ACSS2 UGT2B11	3.27e-04	219	60	6	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	SLC26A2 ACSM1 UGT2B7 UGT2B28 ACSS2 UGT2B11	3.35e-04	220	60	6	M10320
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	3.69e-04	7	60	2	MM14685
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	4.91e-04	8	60	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	4.91e-04	8	60	2	M47872
Pathway	REACTOME_PARACETAMOL_ADME	UGT2B7 UGT2B28 UGT2B11	6.01e-04	39	60	3	MM15695
Pathway	WP_AMINO_ACID_METABOLISM	CAD HADH VARS1 MMUT	6.01e-04	91	60	4	M39570
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS	FASN NR1H2	6.29e-04	9	60	2	M29789
Pathway	KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	UGT2B7 UGT2B28 UGT2B11	6.96e-04	41	60	3	M7399
Pathway	WP_AMINO_ACID_METABOLISM	CAD HADH VARS1 MMUT	7.95e-04	98	60	4	MM15942
Pathway	REACTOME_ASPIRIN_ADME	UGT2B7 UGT2B28 UGT2B11	8.57e-04	44	60	3	M45014
Pathway	KEGG_ABC_TRANSPORTERS	ABCB7 ABCD1 ABCC6	8.57e-04	44	60	3	M11911
Pathway	REACTOME_ASPIRIN_ADME	UGT2B7 UGT2B28 UGT2B11	9.16e-04	45	60	3	MM15694
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	9.56e-04	11	60	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	9.56e-04	11	60	2	M47874
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	FKBP15 PIK3C3 RHOV TOM1 ATP9B ABCD1 HADH	1.12e-03	381	60	7	M48063
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.14e-03	12	60	2	MM1368
Pathway	KEGG_DRUG_METABOLISM_OTHER_ENZYMES	UGT2B7 UGT2B28 UGT2B11	1.32e-03	51	60	3	M17726
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	1.35e-03	13	60	2	M4732
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	UGT2B7 UGT2B28 UGT2B11	1.40e-03	52	60	3	M14171
Pathway	KEGG_STEROID_HORMONE_BIOSYNTHESIS	UGT2B7 UGT2B28 UGT2B11	1.64e-03	55	60	3	M14933
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSYLATION_PRECURSOR_BIOSYNTHESIS	DOLK GFPT1	1.81e-03	15	60	2	M27468
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.81e-03	15	60	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	2.33e-03	17	60	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	2.33e-03	17	60	2	MM1369
Pathway	KEGG_RETINOL_METABOLISM	UGT2B7 UGT2B28 UGT2B11	2.54e-03	64	60	3	M9488
Pathway	REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS	FCSK DOLK GFPT1	2.54e-03	64	60	3	M892
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	3.22e-03	20	60	2	M917
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	UGT2B7 UGT2B28 UGT2B11	3.28e-03	70	60	3	M16794
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B7 UGT2B28 UGT2B11	3.22e-07	7	74	3	26074487
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B7 UGT2B28 UGT2B11	5.14e-07	8	74	3	32093886
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	FASN CAD PA2G4 WDR46 XRCC5 DDX27	6.67e-07	144	74	6	35681168
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	AARS1 FASN FAM234A PA2G4 ADAM9 TOM1 GEMIN4 RANBP6 ABCD1 PJA1 VARS1 GFPT1	6.82e-07	942	74	12	31073040
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	DOCK5 FASN CAD PIK3C3 GEMIN4 UGT2B11 DDX27 GFPT1 DISP1	1.10e-06	496	74	9	31343991
Pubmed	Mapping of the L-methylmalonyl-CoA mutase gene to mouse chromosome 17.	C4A C4B MMUT	2.60e-06	13	74	3	1970332
Pubmed	Network organization of the human autophagy system.	IQGAP2 PIK3C3 PA2G4 GEMIN4 FLCN HADH VARS1 GFPT1	4.26e-06	437	74	8	20562859
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	4.47e-06	2	74	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	4.47e-06	2	74	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	4.47e-06	2	74	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	4.47e-06	2	74	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	4.47e-06	2	74	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	4.47e-06	2	74	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	4.47e-06	2	74	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	4.47e-06	2	74	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	4.47e-06	2	74	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	4.47e-06	2	74	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	4.47e-06	2	74	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	4.47e-06	2	74	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	4.47e-06	2	74	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	4.47e-06	2	74	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	4.47e-06	2	74	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	4.47e-06	2	74	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	4.47e-06	2	74	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	4.47e-06	2	74	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	4.47e-06	2	74	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	4.47e-06	2	74	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	4.47e-06	2	74	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	4.47e-06	2	74	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	4.47e-06	2	74	2	23918728
Pubmed	Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor.	NR1H2 ABCC6	4.47e-06	2	74	2	17045963
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	4.47e-06	2	74	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	4.47e-06	2	74	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	4.47e-06	2	74	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	4.47e-06	2	74	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	4.47e-06	2	74	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	4.47e-06	2	74	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	4.47e-06	2	74	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	4.47e-06	2	74	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	4.47e-06	2	74	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	4.47e-06	2	74	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	4.47e-06	2	74	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	4.47e-06	2	74	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	4.47e-06	2	74	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	4.47e-06	2	74	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	4.47e-06	2	74	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	4.47e-06	2	74	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	4.47e-06	2	74	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	4.47e-06	2	74	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	4.47e-06	2	74	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	4.47e-06	2	74	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	4.47e-06	2	74	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	4.47e-06	2	74	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	4.47e-06	2	74	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	4.47e-06	2	74	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	4.47e-06	2	74	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	4.47e-06	2	74	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	4.47e-06	2	74	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	4.47e-06	2	74	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	4.47e-06	2	74	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	4.47e-06	2	74	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	4.47e-06	2	74	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	4.47e-06	2	74	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	4.47e-06	2	74	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	4.47e-06	2	74	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	4.47e-06	2	74	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	4.47e-06	2	74	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	4.47e-06	2	74	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	4.47e-06	2	74	2	2395880
Pubmed	Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.	UGT2B28 UGT2B11	4.47e-06	2	74	2	21679149
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	4.47e-06	2	74	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	4.47e-06	2	74	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	4.47e-06	2	74	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	4.47e-06	2	74	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	4.47e-06	2	74	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	4.47e-06	2	74	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	4.47e-06	2	74	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	4.47e-06	2	74	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	4.47e-06	2	74	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	4.47e-06	2	74	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	4.47e-06	2	74	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	4.47e-06	2	74	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	4.47e-06	2	74	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	4.47e-06	2	74	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	4.47e-06	2	74	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	4.47e-06	2	74	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	4.47e-06	2	74	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	4.47e-06	2	74	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	4.47e-06	2	74	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	4.47e-06	2	74	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	4.47e-06	2	74	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	4.47e-06	2	74	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	4.47e-06	2	74	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	4.47e-06	2	74	2	28873507
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	4.47e-06	2	74	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	4.47e-06	2	74	2	2900855
Pubmed	Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication.	FASN PIK3C3	4.47e-06	2	74	2	34320401
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	4.47e-06	2	74	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	4.47e-06	2	74	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	4.47e-06	2	74	2	3794341
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	WDR46 C4A C4B MICA TEAD3 VARS1	1.66e-04	503	74	6	chr6p21
Cytoband	6p21.3	WDR46 C4A C4B VARS1	7.33e-04	250	74	4	6p21.3
Cytoband	4q13.2	UGT2B28 UGT2B11	1.16e-03	31	74	2	4q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q13	UGT2B7 UGT2B28 UGT2B11	2.13e-03	157	74	3	chr4q13
GeneFamily	UDP glucuronosyltransferases	UGT2B7 UGT2B28 UGT2B11	7.26e-05	32	46	3	363
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	2.25e-04	9	46	2	1234
GeneFamily	Acyl-CoA synthetase family	ACSM1 ACSS2	1.98e-03	26	46	2	40
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	3.78e-03	36	46	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	3.99e-03	37	46	2	454
Coexpression	YAMASHITA_LIVER_CANCER_WITH_EPCAM_DN	UGT2B7 C4A UGT2B11	1.43e-05	17	74	3	M9914
Coexpression	GSE19888_ADENOSINE_A3R_ACT_VS_A3R_ACT_WITH_A3R_INH_PRETREATMENT_IN_MAST_CELL_UP	AARS1 CAD WDR90 HADH PJA1 COQ3	1.97e-05	196	74	6	M7316
Coexpression	GSE1460_INTRATHYMIC_T_PROGENITOR_VS_DP_THYMOCYTE_DN	FRY PDE4D PLCH2 NR1H2 ATP9B EXOC2	2.02e-05	197	74	6	M3438
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma\|TCGA-Kidney / Sample_Type by Project: Shred V9	FCSK FAM234A ACSM1 ACSS2 GTF2IRD1 VARS1	6.54e-07	185	74	6	46f4f6f20b1e152922f6f2ba1244c56e48a49b79
Drug	2-O-Methylfucose	C4A ABCC6 GFPT1	5.34e-06	11	74	3	CID000169586
Drug	AC1Q68ZE	FASN ACSM1 HADH ACSS2 MMUT	5.91e-06	79	74	5	CID000000265
Drug	testosterone glucuronide	UGT2B7 FLCN UGT2B28 UGT2B11	9.50e-06	41	74	4	CID000108192
Drug	2-hydroxyestriol	UGT2B7 UGT2B11	1.04e-05	2	74	2	ctd:C008012
Drug	phenobarbital	GABRD CAD UGT2B7 GRIA3 UGT2B28 UGT2B11 VARS1 ABCC6	2.20e-05	360	74	8	CID000004763
Drug	AC1NQGK1	UGT2B7 UGT2B28 UGT2B11 ABCC6	2.47e-05	52	74	4	CID005195977
Drug	C1 11-32	UGT2B7 UGT2B28 UGT2B11	2.60e-05	18	74	3	CID000443077
Drug	C11131	UGT2B7 UGT2B28 UGT2B11	2.60e-05	18	74	3	CID000443076
Drug	T4-G	UGT2B7 UGT2B28 UGT2B11	3.08e-05	19	74	3	CID000152424
Drug	R-Q2	C4A MMUT	3.12e-05	3	74	2	CID000095714
Drug	2-aminothiophenol	C4A C4B	3.12e-05	3	74	2	ctd:C005464
Drug	dehydroepiandrosterone sulfate	GABRD BOK SLC26A2 ACSM1 C4A ABCD1 ACSS2	3.28e-05	277	74	7	CID000005244
Drug	acetaminophen glucuronide	UGT2B7 UGT2B28 UGT2B11 ABCC6	4.09e-05	59	74	4	CID000083944
Drug	SN-38G	UGT2B7 UGT2B28 UGT2B11 ABCC6	4.09e-05	59	74	4	CID000443154
Drug	estriol-16-glucuronide	UGT2B7 UGT2B28 UGT2B11	4.20e-05	21	74	3	CID000122281
Drug	HMDS	UGT2B7 GFPT1 MMUT	4.20e-05	21	74	3	CID000013838
Drug	estradiol-3-glucuronide	UGT2B7 UGT2B28 UGT2B11	5.57e-05	23	74	3	CID000066651
Drug	dimethyl itaconate	FASN MMUT	6.23e-05	4	74	2	CID000069240
Drug	oltipraz	UGT2B7 UGT2B28 ADGRV1 UGT2B11 ABCC6	8.46e-05	137	74	5	CID000047318
Drug	L-idaro-1,4-lactone	UGT2B7 UGT2B28 UGT2B11	1.02e-04	28	74	3	CID000078997
Drug	GDP-Ara	FCSK ABCC6	1.04e-04	5	74	2	CID003036025
Drug	methoxyamine hydrochloride	NR1H2 ABCD1	1.04e-04	5	74	2	CID000011639
Disease	cerebellar ataxia (implicated_via_orthology)	AARS1 VPS13A	1.63e-04	8	72	2	DOID:0050753 (implicated_via_orthology)
Disease	Generalized Epilepsy with Febrile Seizures Plus	GABRD ADGRV1	2.09e-04	9	72	2	C3502809
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B7 UGT2B11	2.09e-04	9	72	2	EFO_0600040
Disease	Congenital Disorders of Glycosylation	FCSK DOLK	2.61e-04	10	72	2	C0282577
Disease	X-19141 measurement	UGT2B7 UGT2B11	4.50e-04	13	72	2	EFO_0800799
Disease	renal cell carcinoma (is_implicated_in)	FLCN C4A C4B	6.50e-04	69	72	3	DOID:4450 (is_implicated_in)
Disease	hair colour measurement	PDE4D TENM4 TOM1 RANBP6 HADH EXOC2 ADGRV1	7.54e-04	615	72	7	EFO_0007822
Disease	Intellectual Disability	FCSK FRY FASN ZNF335 PJA1 TET3	7.85e-04	447	72	6	C3714756
Disease	phosphatidylcholine 36:4 measurement	UGT2B28 UGT2B11	8.76e-04	18	72	2	EFO_0010382
Disease	rheumatoid arthritis	ICOSLG TXNDC16 MICA EXOC2 GTF2IRD1 TET3	9.32e-04	462	72	6	EFO_0000685
Disease	lung carcinoma	FRY FASN PDE4D TENM4 EXOC2 DEPDC7	1.16e-03	482	72	6	EFO_0001071
Disease	X-24947 measurement	UGT2B7 UGT2B11	1.31e-03	22	72	2	EFO_0800910
Disease	sphingomyelin 24:1 measurement	MMS22L PDE4D	1.44e-03	23	72	2	EFO_0010398
Disease	Obesity	FASN HADH GFPT1 MMUT	1.61e-03	205	72	4	C0028754
Disease	sunburn	MMS22L PDE4D EXOC2	1.69e-03	96	72	3	EFO_0003958
Disease	mammographic density percentage	INTU TET3	2.28e-03	29	72	2	EFO_0006502

Protein segments in the cluster

Peptide	Gene	Start	Entry
LANVSTHIVAFDAVL	FAM234A	471	Q9H0X4
DETVALTAFVTIALH	C4B	1136	P0C0L5
FDAVVASEVVEHVID	COQ3	216	Q9NZJ6
VDSSEVVIHSADAFA	DPH6	221	Q7L8W6
VASQILVTIAASDHA	ADGRV1	1846	Q8WXG9
FVGSEAVDVIFSHLI	DEPDC7	66	Q96QD5
SALVEHEAVAEAAVV	ACSS2	586	Q9NR19
VVTDAFLAVAGHIFS	BOK	101	Q9UMX3
TISVAVGLSVDFAVH	DISP1	1041	Q96F81
EAIVAALLTRTFTDH	DDX27	451	Q96GQ7
HVSAVAAAAIFVIII	MICA	311	Q29983
SLTEDVVAFAASVAH	ABCD1	196	P33897
GFIANVAHTFVVDVA	PA2G4	116	Q9UQ80
LAEAAVVFAVVLSIH	DOLK	21	Q9UPQ8
LSSEFAVIVEVHAAA	FLCN	431	Q8NFG4
LLLAAVAEVEDVASH	MMS22L	536	Q6ZRQ5
AASVVHSTDLVVEAI	HADH	106	Q16836
ESEFVHVVAISFTAL	ATP9B	1036	O43861
TSALTHDAILVIAEA	GRIA3	306	P42263
EALVNIIAVHAEVFT	EXOC2	801	Q96KP1
AHTVVADALAKAVAE	FHIP2B	356	Q86V87
EILAAIFASAIHDVD	PDE4D	491	Q08499
VTEELAAATAQVSHL	FKBP15	641	Q5T1M5
VALALEVASIDHISE	GABRD	66	O14764
LSVEVTLHVAANFSV	ICOSLG	126	O75144
FHDSVTEIAIEIAFK	INTU	921	Q9ULD6
VFFSVETAERLLATH	FCSK	226	Q8N0W3
DETSTIALFKAHEVA	DOCK5	176	Q9H7D0
ITVETFASIVAHELG	ADAM9	336	Q13443
TVAHIVVEAASLAAD	E4F1	116	Q66K89
VVEAASLAADISHAS	E4F1	121	Q66K89
LESFIHVAVSDSATL	FRY	796	Q5TBA9
EVACVAVHDESAFVV	GTF2IRD1	51	Q9UHL9
FDDIVHSFVSLTAIQ	FASN	546	P49327
AFTASVQHVEAELSA	MED11	51	Q9P086
DETVALTAFVTIALH	C4A	1136	P0C0L4
ACTDTFLVVIVDAIH	OR6K6	216	Q8NGW6
VDAIHAAEIVASFLV	OR6K6	226	Q8NGW6
LSAAVTEAFVRLHEE	VARS1	451	P26640
FESVLVDAFSHVARE	RPRD1B	81	Q9NQG5
VVALVAVAEHSGEFE	TATDN3	36	Q17R31
ASAVIEHTNRVIFLE	GFPT1	281	Q06210
VALVVFAVHTLVAEN	ABCC6	546	O95255
ELSVDEAALHAAVIA	IQGAP2	206	Q13576
RFAHFTELAIISVQE	NR1H2	266	P55055
SLIDESVHALFAAVV	PIK3C3	861	Q8NEB9
VATAVAVATDHVAFL	OCSTAMP	311	Q9BR26
AVATDHVAFLLAQAT	OCSTAMP	316	Q9BR26
VQSHAASALIIFIED	RANBP6	466	O60518
IFIAHRLSTVVDADE	ABCB7	661	O75027
SALVEHPAVAESAVV	ACSM1	486	Q08AH1
ALVHAASAFEVDVVV	CLP1	241	Q92989
NVESSAELVFVSHVI	RNF17	411	Q9BXT8
LQISDAVHFFTEELA	TRIM69	151	Q86WT6
TDTLFDVNAIVAHVL	TXNDC16	116	Q9P2K2
VRSFSLEAAEVLVEH	WDR90	766	Q96KV7
AEVNLAEHSTVITFL	VPS13A	2391	Q96RL7
EVFDSAILSAIEHKA	RHOV	196	Q96L33
SSHAGAFVIVTEEAI	AARS1	731	P49588
ELVVVVAATLASHFG	SLC26A2	336	P50443
HVLVASQDFVESVLV	TOM1	86	O60784
EEASIFVHVAVSDIS	PLCH2	871	O75038
VIAFVFEVSTSEHGA	TEAD3	411	Q99594
VLTHFAVAGETILVD	TNR	986	Q92752
VAIHATLESATALAV	TENM4	1461	Q6N022
DAHDLVAFSAVAEAV	TET3	196	O43151
HEVTVLASSASILFD	UGT2B11	51	O75310
IVEAVDIASAAKHFD	WDR46	176	O15213
ASDGVVAAIAISEHV	CAD	1141	P27708
VSDVVDSDITVHNFV	ZFX	41	P17010
HEVTVLASSASILFD	UGT2B28	51	Q9BY64
HEVTVLASSASILFD	UGT2B7	51	P16662
LEAAAHSAVTAVADA	ZNF335	1291	Q9H4Z2
ALAHLESLAVDVEVA	PJA1	551	Q8NG27
EAAAVALSSLIHALD	XRCC5	371	P13010
EHVTVDTSAEDVAFF	GEMIN4	146	P57678
AVDADVHAVGISTLA	MMUT	661	P22033