Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calmodulin binding	MYO1D MYO10 KCNQ1 MYO1B EEF2K CASK	1.02e-04	230	65	6	GO:0005516
GeneOntologyMolecularFunction	ATP-dependent activity	ACSL6 ATP6V1H MYO1D ATP13A1 MYO10 AACS MYO1B ASCC3 XRCC5	1.59e-04	614	65	9	GO:0140657
GeneOntologyMolecularFunction	microfilament motor activity	MYO1D MYO10 MYO1B	2.56e-04	38	65	3	GO:0000146
GeneOntologyMolecularFunction	protein phosphatase 2A binding	CACNA1B PPP2R2A SHC1	3.45e-04	42	65	3	GO:0051721
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM7A KDM8	5.63e-04	11	65	2	GO:0051864
Domain	N-CoR_GPS2_interact	NCOR1 NCOR2	1.23e-05	2	66	2	IPR031557
Domain	GPS2_interact	NCOR1 NCOR2	1.23e-05	2	66	2	PF15784
Domain	TPR-like_helical_dom	POLR1A IFT172 EEF2K CFAP70 TTC9C XAB2	1.72e-04	233	66	6	IPR011990
Domain	Myosin_TH1	MYO1D MYO1B	2.55e-04	7	66	2	PF06017
Domain	Myosin_TH1	MYO1D MYO1B	2.55e-04	7	66	2	IPR010926
Domain	TH1	MYO1D MYO1B	2.55e-04	7	66	2	PS51757
Domain	Myosin_head_motor_dom	MYO1D MYO10 MYO1B	3.25e-04	38	66	3	IPR001609
Domain	MYOSIN_MOTOR	MYO1D MYO10 MYO1B	3.25e-04	38	66	3	PS51456
Domain	Myosin_head	MYO1D MYO10 MYO1B	3.25e-04	38	66	3	PF00063
Domain	MYSc	MYO1D MYO10 MYO1B	3.25e-04	38	66	3	SM00242
Domain	IQ	MYO1D MYO10 MYO1B	2.03e-03	71	66	3	PF00612
Domain	IQ	MYO1D MYO10 MYO1B	2.95e-03	81	66	3	SM00015
Domain	AMP-binding_CS	ACSL6 AACS	3.78e-03	26	66	2	IPR020845
Domain	SANT_dom	NCOR1 NCOR2	3.78e-03	26	66	2	IPR017884
Domain	PH_dom-like	EPB41L4B DOCK11 MYO10 SHC1 MYO1B PLCE1	3.90e-03	426	66	6	IPR011993
Domain	IQ_motif_EF-hand-BS	MYO1D MYO10 MYO1B	3.98e-03	90	66	3	IPR000048
Domain	IQ	MYO1D MYO10 MYO1B	4.36e-03	93	66	3	PS50096
Domain	AMP_BINDING	ACSL6 AACS	4.38e-03	28	66	2	PS00455
Domain	SANT	NCOR1 NCOR2	4.38e-03	28	66	2	PS51293
Domain	AMP-binding	ACSL6 AACS	5.02e-03	30	66	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSL6 AACS	5.02e-03	30	66	2	IPR000873
Domain	JMJC	KDM7A KDM8	5.70e-03	32	66	2	PS51184
Domain	JmjC_dom	KDM7A KDM8	5.70e-03	32	66	2	IPR003347
Domain	JmjC	KDM7A KDM8	6.05e-03	33	66	2	SM00558
Domain	Myb_DNA-binding	NCOR1 NCOR2	6.79e-03	35	66	2	PF00249
Domain	RA	MYO10 PLCE1	7.17e-03	36	66	2	PF00788
Domain	MYB_LIKE	NCOR1 NCOR2	7.97e-03	38	66	2	PS50090
Pubmed	Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.	NCOR1 NCOR2 XRCC5	2.92e-06	15	66	3	17242407
Pubmed	NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.	NCOR1 NCOR2	3.55e-06	2	66	2	29531310
Pubmed	CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.	NCOR1 NCOR2	3.55e-06	2	66	2	27733359
Pubmed	Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.	NCOR1 NCOR2	3.55e-06	2	66	2	22944139
Pubmed	Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.	NCOR1 NCOR2	3.55e-06	2	66	2	21131350
Pubmed	Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.	NCOR1 NCOR2	3.55e-06	2	66	2	26166430
Pubmed	Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.	NCOR1 NCOR2	3.55e-06	2	66	2	19299558
Pubmed	Unique forms of human and mouse nuclear receptor corepressor SMRT.	NCOR1 NCOR2	3.55e-06	2	66	2	10077563
Pubmed	Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.	NCOR1 NCOR2	3.55e-06	2	66	2	39106294
Pubmed	Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.	NCOR1 NCOR2	3.55e-06	2	66	2	31208445
Pubmed	Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.	NCOR1 NCOR2	1.06e-05	3	66	2	16030140
Pubmed	Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor.	NCOR1 NCOR2	1.06e-05	3	66	2	19098224
Pubmed	The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.	NCOR1 NCOR2	1.06e-05	3	66	2	16373395
Pubmed	Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.	NCOR1 NCOR2	1.06e-05	3	66	2	31404087
Pubmed	Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.	NCOR1 NCOR2	1.06e-05	3	66	2	22337871
Pubmed	Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.	NCOR1 NCOR2	1.06e-05	3	66	2	23292142
Pubmed	Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.	NCOR1 NCOR2	1.06e-05	3	66	2	15016838
Pubmed	Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.	NCOR1 NCOR2	1.06e-05	3	66	2	24268577
Pubmed	Association of neuronal calcium channels with modular adaptor proteins.	CACNA1B CASK	1.06e-05	3	66	2	10455105
Pubmed	Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis.	NCOR1 NCOR2	1.06e-05	3	66	2	34390859
Pubmed	Oligomerization of ETO is obligatory for corepressor interaction.	NCOR1 NCOR2	1.06e-05	3	66	2	11113190
Pubmed	RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.	NCOR1 NCOR2	1.06e-05	3	66	2	12011091
Pubmed	EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.	NCOR1 NCOR2	1.06e-05	3	66	2	21518914
Pubmed	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.	NCOR1 NCOR2	1.06e-05	3	66	2	15802375
Pubmed	SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.	NCOR1 NCOR2	1.06e-05	3	66	2	36238311
Pubmed	The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.	NCOR1 NCOR2	1.06e-05	3	66	2	10406466
Pubmed	Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.	NCOR1 NCOR2	1.06e-05	3	66	2	36316474
Pubmed	The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha.	NCOR1 NCOR2	1.06e-05	3	66	2	18052923
Pubmed	The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.	NCOR1 NCOR2	1.06e-05	3	66	2	11997503
Pubmed	Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor.	NCOR1 NCOR2	1.06e-05	3	66	2	18852122
Pubmed	Whole-genome sequencing reveals host factors underlying critical COVID-19.	ACSL6 ABO DPP9	1.46e-05	25	66	3	35255492
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	EPB41L4B TEX264 IFT172 TTC9C XAB2 CASK SMAD9	1.48e-05	419	66	7	33001583
Pubmed	MicroRNAs are mediators of androgen action in prostate and muscle.	NCOR1 NCOR2	2.12e-05	4	66	2	21048966
Pubmed	Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.	NCOR1 NCOR2	2.12e-05	4	66	2	9819405
Pubmed	Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.	NCOR1 NCOR2	2.12e-05	4	66	2	18362166
Pubmed	Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.	NCOR1 NCOR2	2.12e-05	4	66	2	18632669
Pubmed	Dichotomous engagement of HDAC3 activity governs inflammatory responses.	NCOR1 NCOR2	2.12e-05	4	66	2	32760002
Pubmed	A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones.	NCOR1 NCOR2	2.12e-05	4	66	2	19147680
Pubmed	A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain.	NCOR1 NCOR2	2.12e-05	4	66	2	32072640
Pubmed	NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.	NCOR1 NCOR2	2.12e-05	4	66	2	25421714
Pubmed	Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.	NCOR1 NCOR2	2.12e-05	4	66	2	15878880
Pubmed	FBI-1 functions as a novel AR co-repressor in prostate cancer cells.	NCOR1 NCOR2	2.12e-05	4	66	2	20812024
Pubmed	Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).	NCOR1 NCOR2	2.12e-05	4	66	2	17073437
Pubmed	The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.	NCOR1 NCOR2	2.12e-05	4	66	2	16024608
Pubmed	The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.	NCOR1 NCOR2	2.12e-05	4	66	2	11509652
Pubmed	The retinoid X receptor binding to the thyroid hormone receptor: relationship with cofactor binding and transcriptional activity.	NCOR1 NCOR2	2.12e-05	4	66	2	19211732
Pubmed	Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.	NCOR1 NCOR2	2.12e-05	4	66	2	19595715
Pubmed	Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.	NCOR1 NCOR2	2.12e-05	4	66	2	16121196
Pubmed	A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.	NCOR1 NCOR2	2.12e-05	4	66	2	12840002
Pubmed	Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.	NCOR1 NCOR2	2.12e-05	4	66	2	20003447
Pubmed	A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.	NCOR1 NCOR2	2.12e-05	4	66	2	20543827
Pubmed	GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression.	NCOR1 NCOR2	2.12e-05	4	66	2	26712002
Pubmed	Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.	NCOR1 NCOR2	2.12e-05	4	66	2	26712006
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	NCOR1 NCOR2 PPP2R2A MYO1D SHC1 MYO1B MARVELD2 ELP3 NSD3 CASK	2.72e-05	1049	66	10	27880917
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CACNA1B NCOR1 NCOR2 PPP2R2A DOCK11 IFT172 CASK	3.30e-05	475	66	7	31040226
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	NCOR2 PPP2R2A MYO10 MYO1B XRCC5 ELP3	3.37e-05	321	66	6	32098917
Pubmed	Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.	NCOR1 NCOR2	3.53e-05	5	66	2	7566114
Pubmed	ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus.	NCOR1 NCOR2	3.53e-05	5	66	2	12904255
Pubmed	Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.	NCOR1 NCOR2	3.53e-05	5	66	2	15175761
Pubmed	Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor.	NCOR1 NCOR2	3.53e-05	5	66	2	14593076
Pubmed	Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.	NCOR1 NCOR2	3.53e-05	5	66	2	11865059
Pubmed	Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells.	NCOR1 NCOR2	3.53e-05	5	66	2	21088000
Pubmed	Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells.	NCOR1 NCOR2	3.53e-05	5	66	2	23703729
Pubmed	Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.	NCOR1 NCOR2	3.53e-05	5	66	2	15531890
Pubmed	Combinatorial roles of the nuclear receptor corepressor in transcription and development.	NCOR1 NCOR2	3.53e-05	5	66	2	11030619
Pubmed	Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.	NCOR1 NCOR2	3.53e-05	5	66	2	29033129
Pubmed	Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.	PLCE1 SMAD9	3.53e-05	5	66	2	15743817
Pubmed	The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures.	NCOR1 NCOR2	3.53e-05	5	66	2	16033423
Pubmed	Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.	NCOR1 NCOR2	3.53e-05	5	66	2	16712523
Pubmed	The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3.	NCOR1 NCOR2	3.53e-05	5	66	2	15832170
Pubmed	Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.	NCOR1 NCOR2	3.53e-05	5	66	2	15729358
Pubmed	Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.	NCOR1 NCOR2	3.53e-05	5	66	2	21143702
Pubmed	The histone deacetylase-3 complex contains nuclear receptor corepressors.	NCOR1 NCOR2	3.53e-05	5	66	2	10860984
Pubmed	A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.	NCOR1 NCOR2	3.53e-05	5	66	2	10809664
Pubmed	Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection.	NCOR1 NCOR2	3.53e-05	5	66	2	30664766
Pubmed	Mouse germline restriction of Oct4 expression by germ cell nuclear factor.	NCOR1 NCOR2	3.53e-05	5	66	2	11702949
Pubmed	Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status.	NCOR1 NCOR2	3.53e-05	5	66	2	10803578
Pubmed	Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300.	NCOR1 NCOR2	3.53e-05	5	66	2	14985122
Pubmed	Tagging genes with cassette-exchange sites.	NCOR1 NCOR2 PPP2R2A ZNF277 KDM7A ELP3	4.27e-05	335	66	6	15741177
Pubmed	Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.	NCOR1 NCOR2	5.29e-05	6	66	2	26859354
Pubmed	Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.	NCOR1 NCOR2	5.29e-05	6	66	2	9405624
Pubmed	SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR.	NCOR1 NCOR2	5.29e-05	6	66	2	19955185
Pubmed	Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines.	NCOR1 NCOR2	5.29e-05	6	66	2	18832723
Pubmed	MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer.	NCOR1 NCOR2	5.29e-05	6	66	2	20388878
Pubmed	Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.	MYO1D MYO1B	5.29e-05	6	66	2	12486594
Pubmed	Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis.	NCOR1 NCOR2	5.29e-05	6	66	2	27506116
Pubmed	The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators.	NCOR1 NCOR2	5.29e-05	6	66	2	9878542
Pubmed	AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.	NCOR1 NCOR2	5.29e-05	6	66	2	12460926
Pubmed	Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.	NCOR1 NCOR2	5.29e-05	6	66	2	10640275
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	PPP2R2A POLR1A MYO1D CELF2 EPB41L4B DOCK11 ASCC3 XAB2	6.72e-05	724	66	8	36232890
Pubmed	MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.	NCOR1 NCOR2	7.40e-05	7	66	2	15454082
Pubmed	The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.	NCOR1 NCOR2	7.40e-05	7	66	2	11867749
Pubmed	A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.	NCOR1 NCOR2	7.40e-05	7	66	2	16980585
Pubmed	SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.	NCOR1 NCOR2	7.40e-05	7	66	2	18500350
Pubmed	Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.	NCOR1 NCOR2	7.40e-05	7	66	2	11804585
Pubmed	Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.	NCOR1 NCOR2	7.40e-05	7	66	2	29523594
Pubmed	Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.	NCOR1 NCOR2	7.40e-05	7	66	2	11903058
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	NCOR1 NCOR2	7.40e-05	7	66	2	15695367
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	NCOR1 ATP6V1H MYO1B ELP3 NDUFS2 XAB2 CASK	9.26e-05	560	66	7	35241646
Pubmed	HDAC3 Is a Master Regulator of mTEC Development.	NCOR1 NCOR2	9.86e-05	8	66	2	27068467
GeneFamily	Myosins, class I	MYO1D MYO1B	2.08e-04	8	50	2	1097
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM7A KDM8	1.99e-03	24	50	2	485
GeneFamily	Ataxins\|Trinucleotide repeat containing	NCOR2 CASK	2.16e-03	25	50	2	775
GeneFamily	Acyl-CoA synthetase family	ACSL6 AACS	2.33e-03	26	50	2	40
Coexpression	GSE32423_MEMORY_VS_NAIVE_CD8_TCELL_IL7_IL4_DN	MAN1A2 SLF1 ZNF277 DEPDC5 ASCC3 TTC9C	1.14e-05	200	66	6	M5081
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1B MAN1A2 SLF1 CELF2 ANKRD36 ADAM22	5.21e-07	200	66	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSMC3IP KCNQ1 CC2D2A CFAP70 SMAD9	7.91e-06	184	66	5	e7b9c69fc77040c5191ad8089697051e2589c30e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSMC3IP KCNQ1 CC2D2A CFAP70 SMAD9	9.24e-06	190	66	5	52c59001a079c76249abbaa3141e9e661b83d9a0
ToppCell	Endothelial_cells-Endothelial-B\|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id	SHC1 CCDC80 PCDH12 PLCE1 CASK	1.07e-05	196	66	5	36f95f9ef74eb951e41ef46fd136ceaef45208fc
Drug	halofenate	NCOR1 NCOR2 ABO	9.29e-08	4	66	3	CID000033584
Drug	Androstenols	NCOR1 NCOR2 CYP2B6	5.02e-06	12	66	3	ctd:D000737
Disease	X-11423--O-sulfo-L-tyrosine measurement	ABO PCDH15	7.35e-05	6	66	2	EFO_0021231
Disease	mannosyl-oligosaccharide 1,2-alpha-mannosidase IB measurement	MAN1A2 ABO	7.35e-05	6	66	2	EFO_0801783
Disease	severe acute respiratory syndrome (is_implicated_in)	ACE2 ABO	1.03e-04	7	66	2	DOID:2945 (is_implicated_in)
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	KDM7A CASK	1.37e-04	8	66	2	DOID:0060309 (implicated_via_orthology)
Disease	xanthine measurement	CELF2 ADAM22	3.78e-04	13	66	2	EFO_0010548
Disease	leukemia (is_implicated_in)	ACSL6 ABO	3.78e-04	13	66	2	DOID:1240 (is_implicated_in)
Disease	alkaline phosphatase measurement	CYP2B6 CILP2 MAN1A2 ABO ATP13A1 MYO1B ZNF318 FHIP2A PLCE1	4.15e-04	1015	66	9	EFO_0004533
Disease	immature granulocyte count	ABO DEPDC5	6.56e-04	17	66	2	EFO_0803542
Disease	COVID-19 (is_implicated_in)	ACE2 ABO	1.01e-03	21	66	2	DOID:0080600 (is_implicated_in)
Disease	Ovarian Failure, Premature	PSMC3IP POF1B	1.01e-03	21	66	2	C0085215
Disease	migraine disorder, diastolic blood pressure	NCOR2 PLCE1	1.43e-03	25	66	2	EFO_0006336, MONDO_0005277
Disease	L lactate dehydrogenase measurement	ABO KCNQ1	1.55e-03	26	66	2	EFO_0004808
Disease	glucose tolerance test	ABO KCNQ1	1.67e-03	27	66	2	EFO_0004307
Disease	C-C motif chemokine 7 measurement	ANKRD36 ELP3	1.92e-03	29	66	2	EFO_0008054
Disease	respiratory failure, COVID-19	ABO DPP9	1.92e-03	29	66	2	EFO_0009686, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
RVNIGEVLDKRYNVY	PRPF4B	676	Q13523
NKVPEDRVYEELNIY	MS4A2	211	Q01362
EPYGAVYQINVLRDR	CELF2	61	O95319
KYPHVAERVYREIEQ	CYP2B6	316	P20813
YERRPQSQAYIPKDE	ABO	246	P16442
ENRPVETYQVHEYLR	PPP2R2A	316	P63151
CVPQYNKYREERVIL	AACS	571	Q86V21
YYRQQVTGEPQERDK	AHSP	51	Q9NZD4
YLYREAQARSPEKQE	ATP13A1	1071	Q9HD20
QLRRYPRNVEEETKY	ADAM22	226	Q9P0K1
EYERKRYEDLPINSN	ANKRD36	251	A6QL64
YLDYEKEEVEAQPRQ	CACNA1B	1326	Q00975
LTDVDLRVKQYYEVP	CCDC80	716	Q76M96
YEVERQPGEQEIKFY	PADI1	236	Q9ULC6
DYEKNPAYEVDVQAR	PCDH12	311	Q9NPG4
VFRLRPYQDVYVNVV	DEPDC5	76	O75140
EYYEKQFPEIRKQRE	NCOR2	331	Q9Y618
KGRQIYVRAQFEYDP	CASK	611	O14936
NHEVRQLYRYDKPVE	KDM7A	776	Q6ZMT4
QARKPYDVRDVIEQY	KCNQ1	531	P51787
QDLVQEKYLEYRQVP	MAGEA1	241	P43355
PEEKEQVYRERQKYC	PSMC3IP	156	Q9P2W1
KYIVNEPRDVGYLAQ	KDM8	261	Q8N371
ERIVQYYGCLRDPQE	MAP3K2	416	Q9Y2U5
DVVEQIYKRNPILRY	MYO10	1521	Q9HD67
QPPEKNVVYERVRTY	POF1B	41	Q8WVV4
DLRKTQPYDVYDQVE	NDUFS2	301	O75306
KYREAERLYVTVQEP	IFT172	986	Q9UG01
KLNREVRDYYELVVV	PCDH15	776	Q96QU1
VPEFRNYKQVPVYDR	CC2D2A	921	Q9P2K1
IRYAEIPDESRNVNY	DOCK11	1011	Q5JSL3
RAVPRNVQPYVVYEE	DPP9	401	Q86TI2
AYYKERLVREPQNLD	CFAP70	656	Q5T0N1
EVGKQLRPLYEEYVV	ACE2	171	Q9BYF1
RPYQVELVRRDYVAN	ELP3	416	Q9H9T3
YPVIQTDDERERYKA	MARVELD2	446	Q8N4S9
VRQAEKYYILRPEVI	MAN1A2	521	O60476
RLEPGQQEEYYRKLA	LCAT	171	P04180
NYVAKRYIEPVDRDV	EEF2K	166	O00418
VLRNLEERNYTEYKP	FHIP2A	491	Q5W0V3
NKATEDEYYRRPLQV	CST4	56	P01036
RVKYYSSEPNNLREE	EPB41L4B	161	Q9H329
YERATRAVEPAQQYD	XAB2	616	Q9HCS7
EYVRHYPRGKRVIEQ	ATP6V1H	416	Q9UI12
YYQQEKCLRPEDILR	POLR1A	1326	O95602
EQEQTIYRRVLPVDY	PLCE1	541	Q9P212
LINEHRYPAEIRKYE	NT5DC3	126	Q86UY8
YYEKQFPEIRKQREQ	NCOR1	341	O75376
YCPVRNQYLEKEQRR	PXYLP1	246	Q8TE99
NNRRYEVPHQYVKEF	SI	166	P14410
EGICIERPENQYVYK	SGCG	11	Q13326
QKEVCINPYHYRRVE	SMAD9	121	O15198
EYVAPEKIENIYIRS	ACSL6	566	Q9UKU0
QRENNKLYEEVRIPY	ASCC3	431	Q8N3C0
RVEADKYEYNVVPFR	CILP2	901	Q8IUL8
DPVQAAIDKYVVRYT	TNN	641	Q9UQP3
ERKLCAYPRLEIYQE	TEX264	161	Q9Y6I9
EPVNYERVREYSQKV	TTC9C	86	Q8N5M4
AVRYNCIRIDKQPVY	SLF1	386	Q9BQI6
RIEQYTFIYIDKQPE	NSD3	386	Q9BZ95
INPKNREYDRFYVIN	ZNF277	251	Q9NRM2
YKYGRPDEIIEERIQ	WDR31	36	Q8NA23
NKRAPVRIVYYDPDV	THEGL	426	P0DJG4
KYVDENPLYEERRNL	ZNF318	1166	Q5VUA4
AEYVAYVAKDPVNQR	SHC1	271	P29353
AIVRYAYDKRANPQV	XRCC5	391	P13010
PEKVEEYRNRNFYEL	MYO1B	66	O43795
DTIEQYKGRELYERP	MYO1D	61	O94832