| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | transporter activity | SLC6A12 SLC7A13 KCNB1 KCNJ12 TMEM37 SLC19A2 ANO7 ATP10B ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ABCA8 MFSD12 SLC12A5 KCNH5 | 6.78e-09 | 1289 | 50 | 17 | GO:0005215 |
| GeneOntologyMolecularFunction | gated channel activity | KCNB1 KCNJ12 TMEM37 ANO7 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 KCNH5 | 8.51e-09 | 334 | 50 | 10 | GO:0022836 |
| GeneOntologyMolecularFunction | transmembrane transporter activity | SLC6A12 SLC7A13 KCNB1 KCNJ12 TMEM37 SLC19A2 ANO7 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ABCA8 MFSD12 SLC12A5 KCNH5 | 1.46e-08 | 1180 | 50 | 16 | GO:0022857 |
| GeneOntologyMolecularFunction | metal ion transmembrane transporter activity | SLC6A12 KCNB1 KCNJ12 TMEM37 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 SLC12A5 KCNH5 | 1.60e-08 | 465 | 50 | 11 | GO:0046873 |
| GeneOntologyMolecularFunction | channel activity | KCNB1 KCNJ12 TMEM37 ANO7 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 SLC12A5 KCNH5 | 5.52e-08 | 525 | 50 | 11 | GO:0015267 |
| GeneOntologyMolecularFunction | passive transmembrane transporter activity | KCNB1 KCNJ12 TMEM37 ANO7 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 SLC12A5 KCNH5 | 5.63e-08 | 526 | 50 | 11 | GO:0022803 |
| GeneOntologyMolecularFunction | monoatomic cation channel activity | 1.58e-07 | 343 | 50 | 9 | GO:0005261 | |
| GeneOntologyMolecularFunction | monoatomic ion channel activity | KCNB1 KCNJ12 TMEM37 ANO7 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 KCNH5 | 1.68e-07 | 459 | 50 | 10 | GO:0005216 |
| GeneOntologyMolecularFunction | inorganic molecular entity transmembrane transporter activity | SLC6A12 KCNB1 KCNJ12 TMEM37 ANO7 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 SLC12A5 KCNH5 | 2.64e-07 | 758 | 50 | 12 | GO:0015318 |
| GeneOntologyMolecularFunction | inorganic cation transmembrane transporter activity | SLC6A12 KCNB1 KCNJ12 TMEM37 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 SLC12A5 KCNH5 | 3.29e-07 | 627 | 50 | 11 | GO:0022890 |
| GeneOntologyMolecularFunction | voltage-gated monoatomic ion channel activity | 3.34e-07 | 182 | 50 | 7 | GO:0005244 | |
| GeneOntologyMolecularFunction | voltage-gated channel activity | 3.60e-07 | 184 | 50 | 7 | GO:0022832 | |
| GeneOntologyMolecularFunction | monoatomic ion transmembrane transporter activity | SLC6A12 KCNB1 KCNJ12 TMEM37 ANO7 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 SLC12A5 KCNH5 | 4.28e-07 | 793 | 50 | 12 | GO:0015075 |
| GeneOntologyMolecularFunction | ligand-gated monoatomic ion channel activity | 4.97e-07 | 193 | 50 | 7 | GO:0015276 | |
| GeneOntologyMolecularFunction | ligand-gated channel activity | 5.70e-07 | 197 | 50 | 7 | GO:0022834 | |
| GeneOntologyMolecularFunction | monoatomic cation transmembrane transporter activity | SLC6A12 KCNB1 KCNJ12 TMEM37 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 SLC12A5 KCNH5 | 5.80e-07 | 664 | 50 | 11 | GO:0008324 |
| GeneOntologyMolecularFunction | transmembrane signaling receptor activity | TSPAN12 LIFR TAS2R8 OR52A4P TRHR SCTR IL20RB OR13G1 ADGRF3 GRIN3A ADGRV1 TAS2R20 GRIN3B PLXNB2 OR6X1 | 6.35e-07 | 1353 | 50 | 15 | GO:0004888 |
| GeneOntologyMolecularFunction | dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity | 6.14e-06 | 2 | 50 | 2 | GO:0106073 | |
| GeneOntologyMolecularFunction | amino acid transmembrane transporter activity | 6.41e-06 | 105 | 50 | 5 | GO:0015171 | |
| GeneOntologyMolecularFunction | carboxylic acid transmembrane transporter activity | 1.25e-05 | 207 | 50 | 6 | GO:0046943 | |
| GeneOntologyMolecularFunction | organic acid transmembrane transporter activity | 1.29e-05 | 208 | 50 | 6 | GO:0005342 | |
| GeneOntologyMolecularFunction | potassium ion transmembrane transporter activity | 6.02e-05 | 167 | 50 | 5 | GO:0015079 | |
| GeneOntologyMolecularFunction | organic anion transmembrane transporter activity | 8.76e-05 | 293 | 50 | 6 | GO:0008514 | |
| GeneOntologyMolecularFunction | voltage-gated potassium channel activity | 1.23e-04 | 102 | 50 | 4 | GO:0005249 | |
| GeneOntologyMolecularFunction | NMDA glutamate receptor activity | 1.70e-04 | 8 | 50 | 2 | GO:0004972 | |
| GeneOntologyMolecularFunction | potassium channel activity | 2.95e-04 | 128 | 50 | 4 | GO:0005267 | |
| GeneOntologyMolecularFunction | calcium channel activity | 3.04e-04 | 129 | 50 | 4 | GO:0005262 | |
| GeneOntologyMolecularFunction | G protein-coupled receptor activity | 3.06e-04 | 884 | 50 | 9 | GO:0004930 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic cation channel activity | 4.15e-04 | 140 | 50 | 4 | GO:0099094 | |
| GeneOntologyMolecularFunction | glycine binding | 5.49e-04 | 14 | 50 | 2 | GO:0016594 | |
| GeneOntologyMolecularFunction | calcium ion transmembrane transporter activity | 5.52e-04 | 151 | 50 | 4 | GO:0015085 | |
| GeneOntologyMolecularFunction | voltage-gated monoatomic cation channel activity | 5.66e-04 | 152 | 50 | 4 | GO:0022843 | |
| GeneOntologyMolecularFunction | glutamate-gated receptor activity | 8.16e-04 | 17 | 50 | 2 | GO:0004970 | |
| GeneOntologyMolecularFunction | glucosyltransferase activity | 1.37e-03 | 22 | 50 | 2 | GO:0046527 | |
| GeneOntologyMolecularFunction | chloride:monoatomic cation symporter activity | 1.50e-03 | 23 | 50 | 2 | GO:0015377 | |
| GeneOntologyMolecularFunction | nuclear steroid receptor activity | 1.78e-03 | 25 | 50 | 2 | GO:0003707 | |
| GeneOntologyMolecularFunction | monoatomic anion:monoatomic cation symporter activity | 1.92e-03 | 26 | 50 | 2 | GO:0015296 | |
| GeneOntologyMolecularFunction | glutamate receptor activity | 2.07e-03 | 27 | 50 | 2 | GO:0008066 | |
| GeneOntologyMolecularFunction | bitter taste receptor activity | 2.07e-03 | 27 | 50 | 2 | GO:0033038 | |
| GeneOntologyMolecularFunction | inward rectifier potassium channel activity | 2.23e-03 | 28 | 50 | 2 | GO:0005242 | |
| GeneOntologyMolecularFunction | TBP-class protein binding | 3.09e-03 | 33 | 50 | 2 | GO:0017025 | |
| GeneOntologyMolecularFunction | taste receptor activity | 3.09e-03 | 33 | 50 | 2 | GO:0008527 | |
| GeneOntologyMolecularFunction | chloride transmembrane transporter activity | 3.79e-03 | 125 | 50 | 3 | GO:0015108 | |
| GeneOntologyMolecularFunction | symporter activity | 6.29e-03 | 150 | 50 | 3 | GO:0015293 | |
| GeneOntologyMolecularFunction | secondary active transmembrane transporter activity | 6.38e-03 | 296 | 50 | 4 | GO:0015291 | |
| GeneOntologyMolecularFunction | monoatomic anion transmembrane transporter activity | 6.41e-03 | 151 | 50 | 3 | GO:0008509 | |
| GeneOntologyMolecularFunction | active transmembrane transporter activity | 6.67e-03 | 477 | 50 | 5 | GO:0022804 | |
| GeneOntologyMolecularFunction | intramembrane lipid transporter activity | 7.24e-03 | 51 | 50 | 2 | GO:0140303 | |
| GeneOntologyMolecularFunction | sodium channel activity | 7.52e-03 | 52 | 50 | 2 | GO:0005272 | |
| GeneOntologyMolecularFunction | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 8.98e-03 | 57 | 50 | 2 | GO:1904315 | |
| GeneOntologyMolecularFunction | inorganic anion transmembrane transporter activity | 9.01e-03 | 171 | 50 | 3 | GO:0015103 | |
| GeneOntologyMolecularFunction | sodium ion transmembrane transporter activity | 9.01e-03 | 171 | 50 | 3 | GO:0015081 | |
| GeneOntologyMolecularFunction | nuclear receptor activity | 9.91e-03 | 60 | 50 | 2 | GO:0004879 | |
| GeneOntologyMolecularFunction | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 9.91e-03 | 60 | 50 | 2 | GO:0099529 | |
| GeneOntologyMolecularFunction | sulfur compound transmembrane transporter activity | 1.02e-02 | 61 | 50 | 2 | GO:1901682 | |
| GeneOntologyMolecularFunction | ligand-activated transcription factor activity | 1.02e-02 | 61 | 50 | 2 | GO:0098531 | |
| GeneOntologyMolecularFunction | general transcription initiation factor binding | 1.12e-02 | 64 | 50 | 2 | GO:0140296 | |
| GeneOntologyMolecularFunction | transmitter-gated channel activity | 1.16e-02 | 65 | 50 | 2 | GO:0022835 | |
| GeneOntologyMolecularFunction | transmitter-gated monoatomic ion channel activity | 1.16e-02 | 65 | 50 | 2 | GO:0022824 | |
| GeneOntologyMolecularFunction | lipid transporter activity | 1.30e-02 | 196 | 50 | 3 | GO:0005319 | |
| GeneOntologyMolecularFunction | amino acid binding | 1.44e-02 | 73 | 50 | 2 | GO:0016597 | |
| GeneOntologyMolecularFunction | phospholipid transporter activity | 1.48e-02 | 74 | 50 | 2 | GO:0005548 | |
| GeneOntologyBiologicalProcess | inorganic ion transmembrane transport | SLC6A12 KCNB1 KCNJ12 ALG10 TMEM37 ANO7 MAIP1 NR3C2 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ALG10B SLC12A5 KCNH5 | 7.82e-10 | 1017 | 49 | 16 | GO:0098660 |
| GeneOntologyBiologicalProcess | inorganic cation transmembrane transport | SLC6A12 KCNB1 KCNJ12 ALG10 TMEM37 MAIP1 NR3C2 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ALG10B SLC12A5 KCNH5 | 1.92e-09 | 922 | 49 | 15 | GO:0098662 |
| GeneOntologyBiologicalProcess | monoatomic cation transmembrane transport | SLC6A12 KCNB1 KCNJ12 ALG10 TMEM37 MAIP1 NR3C2 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ALG10B SLC12A5 KCNH5 | 2.58e-09 | 942 | 49 | 15 | GO:0098655 |
| GeneOntologyBiologicalProcess | monoatomic ion transmembrane transport | SLC6A12 KCNB1 KCNJ12 ALG10 TMEM37 ANO7 MAIP1 NR3C2 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ALG10B SLC12A5 KCNH5 | 2.95e-09 | 1115 | 49 | 16 | GO:0034220 |
| GeneOntologyBiologicalProcess | metal ion transport | SLC6A12 KCNB1 KCNJ12 ALG10 TMEM37 MAIP1 NR3C2 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ALG10B SLC12A5 KCNH5 | 5.79e-09 | 1000 | 49 | 15 | GO:0030001 |
| GeneOntologyBiologicalProcess | monoatomic cation transport | SLC6A12 KCNB1 KCNJ12 ALG10 TMEM37 MAIP1 NR3C2 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ALG10B SLC12A5 KCNH5 | 4.06e-08 | 1157 | 49 | 15 | GO:0006812 |
| GeneOntologyBiologicalProcess | monoatomic ion transport | SLC6A12 KCNB1 KCNJ12 ALG10 TMEM37 ANO7 MAIP1 NR3C2 ASIC5 GRIN3A KCNJ18 GRIN3B CNGA3 ALG10B SLC12A5 KCNH5 | 5.65e-08 | 1374 | 49 | 16 | GO:0006811 |
| GeneOntologyBiologicalProcess | potassium ion transmembrane transport | 6.88e-08 | 232 | 49 | 8 | GO:0071805 | |
| GeneOntologyBiologicalProcess | potassium ion transport | 2.33e-07 | 272 | 49 | 8 | GO:0006813 | |
| GeneOntologyBiologicalProcess | pigment metabolic process involved in pigmentation | 5.50e-05 | 5 | 49 | 2 | GO:0043474 | |
| GeneOntologyBiologicalProcess | cell volume homeostasis | 1.36e-04 | 42 | 49 | 3 | GO:0006884 | |
| GeneOntologyBiologicalProcess | modified amino acid transport | 1.56e-04 | 44 | 49 | 3 | GO:0072337 | |
| GeneOntologyBiologicalProcess | sensory perception | TYR TAS2R8 OR52A4P ALG10 OR13G1 ADGRV1 TAS2R20 CNGA3 OR6X1 ALG10B | 1.78e-04 | 1072 | 49 | 10 | GO:0007600 |
| GeneOntologyBiologicalProcess | intracellular water homeostasis | 1.97e-04 | 9 | 49 | 2 | GO:0009992 | |
| GeneOntologyBiologicalProcess | potassium ion import across plasma membrane | 2.42e-04 | 51 | 49 | 3 | GO:1990573 | |
| GeneOntologyBiologicalProcess | G protein-coupled receptor signaling pathway | PDE3A TAS2R8 OR52A4P TRHR SCTR OR13G1 NR3C2 ADGRF3 ADGRV1 TAS2R20 OR6X1 | 3.48e-04 | 1395 | 49 | 11 | GO:0007186 |
| GeneOntologyBiologicalProcess | inorganic ion import across plasma membrane | 3.59e-04 | 142 | 49 | 4 | GO:0099587 | |
| GeneOntologyBiologicalProcess | inorganic cation import across plasma membrane | 3.59e-04 | 142 | 49 | 4 | GO:0098659 | |
| GeneOntologyBiologicalProcess | glutamate receptor signaling pathway | 3.73e-04 | 59 | 49 | 3 | GO:0007215 | |
| GeneOntologyBiologicalProcess | organic cation transport | 3.88e-04 | 145 | 49 | 4 | GO:0015695 | |
| GeneOntologyBiologicalProcess | sulfur amino acid transport | 4.24e-04 | 13 | 49 | 2 | GO:0000101 | |
| GeneOntologyBiologicalProcess | sulfur compound transport | 4.96e-04 | 65 | 49 | 3 | GO:0072348 | |
| GeneOntologyBiologicalProcess | inner ear receptor cell development | 6.97e-04 | 73 | 49 | 3 | GO:0060119 | |
| GeneOntologyCellularComponent | monoatomic ion channel complex | 2.45e-07 | 378 | 50 | 9 | GO:0034702 | |
| GeneOntologyCellularComponent | transporter complex | KCNB1 KCNJ12 TMEM37 ATP10B GRIN3A KCNJ18 GRIN3B CNGA3 CNIH3 KCNH5 | 5.84e-07 | 550 | 50 | 10 | GO:1990351 |
| GeneOntologyCellularComponent | transmembrane transporter complex | 3.61e-06 | 523 | 50 | 9 | GO:1902495 | |
| GeneOntologyCellularComponent | ionotropic glutamate receptor complex | 1.70e-04 | 45 | 50 | 3 | GO:0008328 | |
| GeneOntologyCellularComponent | NMDA selective glutamate receptor complex | 2.00e-04 | 9 | 50 | 2 | GO:0017146 | |
| GeneOntologyCellularComponent | neurotransmitter receptor complex | 2.33e-04 | 50 | 50 | 3 | GO:0098878 | |
| GeneOntologyCellularComponent | receptor complex | 4.38e-04 | 581 | 50 | 7 | GO:0043235 | |
| GeneOntologyCellularComponent | neuron projection membrane | 9.98e-04 | 82 | 50 | 3 | GO:0032589 | |
| GeneOntologyCellularComponent | pigment granule membrane | 1.26e-03 | 22 | 50 | 2 | GO:0090741 | |
| GeneOntologyCellularComponent | chitosome | 1.26e-03 | 22 | 50 | 2 | GO:0045009 | |
| GeneOntologyCellularComponent | melanosome membrane | 1.26e-03 | 22 | 50 | 2 | GO:0033162 | |
| GeneOntologyCellularComponent | postsynaptic specialization membrane | 1.35e-03 | 201 | 50 | 4 | GO:0099634 | |
| GeneOntologyCellularComponent | postsynaptic membrane | 2.76e-03 | 405 | 50 | 5 | GO:0045211 | |
| GeneOntologyCellularComponent | neuronal cell body | 3.54e-03 | 835 | 50 | 7 | GO:0043025 | |
| MousePheno | abnormal olfactory bulb periglomerular cell morphology | 2.27e-05 | 3 | 39 | 2 | MP:0009943 | |
| MousePheno | abnormal cochlear outer hair cell physiology | 6.27e-05 | 28 | 39 | 3 | MP:0004434 | |
| MousePheno | abnormal somatic nervous system physiology | 8.11e-05 | 83 | 39 | 4 | MP:0005423 | |
| MousePheno | abnormal distortion product otoacoustic emission | 8.90e-05 | 85 | 39 | 4 | MP:0004736 | |
| MousePheno | abnormal otoacoustic response | 9.32e-05 | 86 | 39 | 4 | MP:0006336 | |
| MousePheno | cochlear outer hair cell degeneration | 9.32e-05 | 86 | 39 | 4 | MP:0004404 | |
| MousePheno | abnormal somatic sensory system morphology | 1.05e-04 | 702 | 39 | 9 | MP:0000959 | |
| MousePheno | abnormal olfactory bulb interneuron morphology | 1.58e-04 | 7 | 39 | 2 | MP:0009941 | |
| MousePheno | abnormal cochlear hair cell physiology | 1.85e-04 | 40 | 39 | 3 | MP:0004432 | |
| MousePheno | absent distortion product otoacoustic emissions | 1.99e-04 | 41 | 39 | 3 | MP:0004737 | |
| MousePheno | cochlear hair cell degeneration | 2.09e-04 | 106 | 39 | 4 | MP:0004362 | |
| MousePheno | absent cochlear microphonics | 3.37e-04 | 10 | 39 | 2 | MP:0004413 | |
| MousePheno | abnormal hair cell physiology | 3.38e-04 | 49 | 39 | 3 | MP:0003879 | |
| MousePheno | abnormal cochlear labyrinth morphology | 4.65e-04 | 235 | 39 | 5 | MP:0004426 | |
| MousePheno | abnormal scala media morphology | 4.65e-04 | 235 | 39 | 5 | MP:0003169 | |
| MousePheno | increased or absent threshold for auditory brainstem response | 4.74e-04 | 236 | 39 | 5 | MP:0011967 | |
| MousePheno | abnormal olfactory bulb glomerular layer morphology | 4.92e-04 | 12 | 39 | 2 | MP:0009948 | |
| MousePheno | absent coat pigmentation | 4.92e-04 | 12 | 39 | 2 | MP:0005171 | |
| MousePheno | bleb | 5.80e-04 | 13 | 39 | 2 | MP:0008854 | |
| MousePheno | abnormal cochlea morphology | 5.94e-04 | 248 | 39 | 5 | MP:0000031 | |
| MousePheno | abnormal hippocampal pyramidal neuron dendrite morphology | 6.76e-04 | 14 | 39 | 2 | MP:0020338 | |
| MousePheno | abnormal membranous labyrinth morphology | 7.61e-04 | 262 | 39 | 5 | MP:0000035 | |
| MousePheno | abnormal cochlear outer hair cell morphology | 9.72e-04 | 159 | 39 | 4 | MP:0004399 | |
| MousePheno | abnormal sensory neuron physiology | 1.05e-03 | 72 | 39 | 3 | MP:0010055 | |
| MousePheno | abnormal cochlear microphonics | 1.13e-03 | 18 | 39 | 2 | MP:0004412 | |
| Domain | K_chnl_inward-rec_Kir2.2 | 6.47e-06 | 2 | 48 | 2 | IPR003272 | |
| Domain | Alg10 | 6.47e-06 | 2 | 48 | 2 | IPR016900 | |
| Domain | DIE2_ALG10 | 6.47e-06 | 2 | 48 | 2 | PF04922 | |
| Domain | K_chnl_inward-rec_Kir_N | 1.94e-05 | 3 | 48 | 2 | IPR013673 | |
| Domain | IRK_N | 1.94e-05 | 3 | 48 | 2 | PF08466 | |
| Domain | G_PROTEIN_RECEP_F2_1 | 1.47e-04 | 40 | 48 | 3 | PS00649 | |
| Domain | G_PROTEIN_RECEP_F2_3 | 1.47e-04 | 40 | 48 | 3 | PS50227 | |
| Domain | GPCR_2_extracellular_dom | 1.47e-04 | 40 | 48 | 3 | IPR001879 | |
| Domain | PMP22_EMP_MP20 | 2.30e-04 | 9 | 48 | 2 | IPR004032 | |
| Domain | PMP22_2 | 2.30e-04 | 9 | 48 | 2 | PS01222 | |
| Domain | PMP22_1 | 2.30e-04 | 9 | 48 | 2 | PS01221 | |
| Domain | G_PROTEIN_RECEP_F2_2 | 2.87e-04 | 50 | 48 | 3 | PS00650 | |
| Domain | 7tm_2 | 2.87e-04 | 50 | 48 | 3 | PF00002 | |
| Domain | GPCR_2-like | 4.92e-04 | 60 | 48 | 3 | IPR017981 | |
| Domain | GPCR_2_secretin-like | 4.92e-04 | 60 | 48 | 3 | IPR000832 | |
| Domain | G_PROTEIN_RECEP_F2_4 | 5.16e-04 | 61 | 48 | 3 | PS50261 | |
| Domain | K_chnl_volt-dep_EAG/ELK/ERG | 5.77e-04 | 14 | 48 | 2 | IPR003938 | |
| Domain | K_chnl_inward-rec_Kir_cyto | 7.58e-04 | 16 | 48 | 2 | IPR013518 | |
| Domain | IRK | 7.58e-04 | 16 | 48 | 2 | PF01007 | |
| Domain | - | 7.58e-04 | 16 | 48 | 2 | 2.60.40.1400 | |
| Domain | K_chnl_inward-rec_Kir | 7.58e-04 | 16 | 48 | 2 | IPR016449 | |
| Domain | Iontro_rcpt | 9.64e-04 | 18 | 48 | 2 | IPR001320 | |
| Domain | Lig_chan | 9.64e-04 | 18 | 48 | 2 | PF00060 | |
| Domain | Lig_chan-Glu_bd | 9.64e-04 | 18 | 48 | 2 | PF10613 | |
| Domain | PBPe | 9.64e-04 | 18 | 48 | 2 | SM00079 | |
| Domain | Iono_rcpt_met | 9.64e-04 | 18 | 48 | 2 | IPR001508 | |
| Domain | Glu/Gly-bd | 9.64e-04 | 18 | 48 | 2 | IPR019594 | |
| Domain | Lig_chan-Glu_bd | 9.64e-04 | 18 | 48 | 2 | SM00918 | |
| Domain | AA-permease/SLC12A_dom | 1.45e-03 | 22 | 48 | 2 | IPR004841 | |
| Domain | AA_permease | 1.45e-03 | 22 | 48 | 2 | PF00324 | |
| Domain | TAS2R | 2.02e-03 | 26 | 48 | 2 | PF05296 | |
| Domain | T2R | 2.02e-03 | 26 | 48 | 2 | IPR007960 | |
| Domain | HRM | 2.34e-03 | 28 | 48 | 2 | PF02793 | |
| Domain | Ig_E-set | 2.42e-03 | 104 | 48 | 3 | IPR014756 | |
| Domain | CNMP_BINDING_1 | 3.05e-03 | 32 | 48 | 2 | PS00888 | |
| Domain | CNMP_BINDING_2 | 3.05e-03 | 32 | 48 | 2 | PS00889 | |
| Domain | Ion_trans_dom | 3.14e-03 | 114 | 48 | 3 | IPR005821 | |
| Domain | Ion_trans | 3.14e-03 | 114 | 48 | 3 | PF00520 | |
| Domain | cNMP | 3.44e-03 | 34 | 48 | 2 | SM00100 | |
| Domain | GPS | 3.44e-03 | 34 | 48 | 2 | SM00303 | |
| Domain | cNMP_binding | 3.44e-03 | 34 | 48 | 2 | PF00027 | |
| Domain | GPCR_2_secretin-like_CS | 3.44e-03 | 34 | 48 | 2 | IPR017983 | |
| Domain | cNMP-bd_dom | 3.65e-03 | 35 | 48 | 2 | IPR000595 | |
| Domain | GPS | 3.65e-03 | 35 | 48 | 2 | PF01825 | |
| Domain | CNMP_BINDING_3 | 3.65e-03 | 35 | 48 | 2 | PS50042 | |
| Domain | GPS | 3.85e-03 | 36 | 48 | 2 | PS50221 | |
| Domain | GPS | 4.07e-03 | 37 | 48 | 2 | IPR000203 | |
| Domain | cNMP-bd-like | 4.29e-03 | 38 | 48 | 2 | IPR018490 | |
| Domain | Peripla_BP_I | 4.51e-03 | 39 | 48 | 2 | IPR028082 | |
| Domain | - | 6.77e-03 | 48 | 48 | 2 | 2.60.120.10 | |
| Domain | RmlC-like_jellyroll | 7.61e-03 | 51 | 48 | 2 | IPR014710 | |
| Pathway | REACTOME_POTASSIUM_CHANNELS | 2.01e-04 | 98 | 42 | 4 | MM14545 | |
| Pathway | REACTOME_NEURONAL_SYSTEM | 4.39e-04 | 335 | 42 | 6 | MM14503 | |
| Pathway | KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST | 4.69e-04 | 11 | 42 | 2 | M47614 | |
| Pathway | KEGG_TASTE_TRANSDUCTION | 4.91e-04 | 52 | 42 | 3 | M5785 | |
| Pubmed | 1.87e-06 | 17 | 50 | 3 | 24086760 | ||
| Pubmed | 2.03e-06 | 2 | 50 | 2 | 32248400 | ||
| Pubmed | Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse. | 2.03e-06 | 2 | 50 | 2 | 15705530 | |
| Pubmed | 2.03e-06 | 2 | 50 | 2 | 11735224 | ||
| Pubmed | 2.03e-06 | 2 | 50 | 2 | 20016182 | ||
| Pubmed | 4.85e-06 | 23 | 50 | 3 | 12955145 | ||
| Pubmed | 6.07e-06 | 3 | 50 | 2 | 8083233 | ||
| Pubmed | Secretin deficiency causes impairment in survival of neural progenitor cells in mice. | 6.07e-06 | 3 | 50 | 2 | 21159798 | |
| Pubmed | 6.07e-06 | 3 | 50 | 2 | 11410627 | ||
| Pubmed | 6.07e-06 | 3 | 50 | 2 | 17640933 | ||
| Pubmed | 6.07e-06 | 3 | 50 | 2 | 24303013 | ||
| Pubmed | 6.07e-06 | 3 | 50 | 2 | 10904001 | ||
| Pubmed | 1.21e-05 | 4 | 50 | 2 | 8921409 | ||
| Pubmed | The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. | 1.21e-05 | 4 | 50 | 2 | 14525949 | |
| Pubmed | 1.21e-05 | 4 | 50 | 2 | 20798526 | ||
| Pubmed | 1.21e-05 | 4 | 50 | 2 | 32990585 | ||
| Pubmed | NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons. | 1.21e-05 | 4 | 50 | 2 | 15813953 | |
| Pubmed | 2.02e-05 | 5 | 50 | 2 | 16177047 | ||
| Pubmed | 3.03e-05 | 6 | 50 | 2 | 9529344 | ||
| Pubmed | 3.03e-05 | 6 | 50 | 2 | 7580148 | ||
| Pubmed | HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. | 4.23e-05 | 7 | 50 | 2 | 11606043 | |
| Pubmed | HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. | 4.23e-05 | 7 | 50 | 2 | 11483648 | |
| Pubmed | 4.23e-05 | 7 | 50 | 2 | 10197777 | ||
| Pubmed | 4.23e-05 | 7 | 50 | 2 | 14644469 | ||
| Pubmed | 4.23e-05 | 7 | 50 | 2 | 12414113 | ||
| Pubmed | 4.23e-05 | 7 | 50 | 2 | 12775422 | ||
| Pubmed | Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. | 4.23e-05 | 7 | 50 | 2 | 7569905 | |
| Pubmed | HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors. | 4.23e-05 | 7 | 50 | 2 | 22940423 | |
| Pubmed | Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. | 5.64e-05 | 8 | 50 | 2 | 8804048 | |
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 9651389 | ||
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 8724036 | ||
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 8845955 | ||
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 16489129 | ||
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 8822372 | ||
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 8563977 | ||
| Pubmed | HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. | 5.64e-05 | 8 | 50 | 2 | 8821747 | |
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 10448428 | ||
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 7695237 | ||
| Pubmed | Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS. | 5.64e-05 | 8 | 50 | 2 | 27930290 | |
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 8955056 | ||
| Pubmed | 5.64e-05 | 8 | 50 | 2 | 10555109 | ||
| Pubmed | D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity. | 7.25e-05 | 9 | 50 | 2 | 22552781 | |
| Pubmed | 7.25e-05 | 9 | 50 | 2 | 21491143 | ||
| Pubmed | 7.25e-05 | 9 | 50 | 2 | 16554481 | ||
| Pubmed | 8.42e-05 | 160 | 50 | 4 | 23375831 | ||
| Pubmed | 9.05e-05 | 10 | 50 | 2 | 19332541 | ||
| Pubmed | 9.05e-05 | 10 | 50 | 2 | 14960569 | ||
| Pubmed | 1.10e-04 | 11 | 50 | 2 | 8581564 | ||
| Pubmed | HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells. | 1.10e-04 | 11 | 50 | 2 | 24739951 | |
| Pubmed | Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells. | 1.10e-04 | 11 | 50 | 2 | 16481105 | |
| Pubmed | 1.56e-04 | 13 | 50 | 2 | 10049592 | ||
| Pubmed | 1.82e-04 | 14 | 50 | 2 | 15749123 | ||
| Pubmed | 1.82e-04 | 14 | 50 | 2 | 19850283 | ||
| Pubmed | Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport. | 2.10e-04 | 15 | 50 | 2 | 21948112 | |
| Pubmed | PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis. | 3.05e-04 | 18 | 50 | 2 | 21511879 | |
| Pubmed | 4.18e-04 | 21 | 50 | 2 | 22114277 | ||
| Pubmed | 4.18e-04 | 21 | 50 | 2 | 10761934 | ||
| Pubmed | Rare independent mutations in renal salt handling genes contribute to blood pressure variation. | 4.59e-04 | 22 | 50 | 2 | 18391953 | |
| Pubmed | Glutamate can act as a signaling molecule in mouse preimplantation embryos†. | 5.48e-04 | 24 | 50 | 2 | 35746896 | |
| Pubmed | Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro. | 5.48e-04 | 24 | 50 | 2 | 36109497 | |
| Pubmed | 5.95e-04 | 25 | 50 | 2 | 12139982 | ||
| Pubmed | Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. | 6.44e-04 | 26 | 50 | 2 | 9745929 | |
| Pubmed | Molecular mechanisms of bitter and sweet taste transduction. | 6.44e-04 | 26 | 50 | 2 | 11696554 | |
| Pubmed | 6.95e-04 | 27 | 50 | 2 | 12581520 | ||
| Pubmed | 6.95e-04 | 27 | 50 | 2 | 17273973 | ||
| Pubmed | 6.95e-04 | 27 | 50 | 2 | 24550280 | ||
| Pubmed | Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. | 7.48e-04 | 28 | 50 | 2 | 15744053 | |
| Pubmed | The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. | 8.02e-04 | 29 | 50 | 2 | 15203201 | |
| Pubmed | 9.15e-04 | 300 | 50 | 4 | 19086053 | ||
| Pubmed | Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. | 9.17e-04 | 31 | 50 | 2 | 17473172 | |
| Pubmed | Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. | 1.02e-03 | 137 | 50 | 3 | 30862715 | |
| Pubmed | 1.04e-03 | 33 | 50 | 2 | 19526283 | ||
| Pubmed | International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. | 1.04e-03 | 33 | 50 | 2 | 25713288 | |
| Pubmed | 1.10e-03 | 34 | 50 | 2 | 15496549 | ||
| Interaction | KCNH1 interactions | 1.27e-05 | 19 | 49 | 3 | int:KCNH1 | |
| Interaction | CD79A interactions | 3.99e-05 | 262 | 49 | 6 | int:CD79A | |
| Cytoband | 12q12 | 1.27e-03 | 47 | 51 | 2 | 12q12 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr12q12 | 2.26e-03 | 63 | 51 | 2 | chr12q12 | |
| Cytoband | 12p13 | 2.33e-03 | 64 | 51 | 2 | 12p13 | |
| GeneFamily | Alpha-1,2-glucosyltransferases | 4.08e-06 | 2 | 37 | 2 | 448 | |
| GeneFamily | Glutamate ionotropic receptor NMDA type subunits | 8.50e-05 | 7 | 37 | 2 | 1201 | |
| GeneFamily | Potassium voltage-gated channel subfamily J | 4.80e-04 | 16 | 37 | 2 | 276 | |
| GeneFamily | Taste 2 receptors | 2.88e-03 | 39 | 37 | 2 | 1162 | |
| GeneFamily | Potassium voltage-gated channels | 3.03e-03 | 40 | 37 | 2 | 274 | |
| GeneFamily | Solute carriers | 8.39e-03 | 395 | 37 | 4 | 752 | |
| Drug | dofetilide | 4.48e-09 | 63 | 49 | 6 | CID000071329 | |
| Disease | Long Qt Syndrome 2 | 7.44e-06 | 3 | 47 | 2 | C3150943 | |
| Disease | nonsyndromic deafness (implicated_via_orthology) | 3.71e-05 | 6 | 47 | 2 | DOID:0050563 (implicated_via_orthology) | |
| Disease | cutaneous melanoma | 4.19e-05 | 121 | 47 | 4 | EFO_0000389 | |
| Disease | cutaneous melanoma, hair color | 1.34e-04 | 62 | 47 | 3 | EFO_0000389, EFO_0003924 | |
| Disease | Disorder of eye | 3.63e-04 | 212 | 47 | 4 | C0015397 | |
| Disease | nevus count, cutaneous melanoma | 4.17e-04 | 91 | 47 | 3 | EFO_0000389, EFO_0004632 | |
| Disease | Schizophrenia | 4.65e-04 | 883 | 47 | 7 | C0036341 | |
| Disease | QT interval | 1.56e-03 | 534 | 47 | 5 | EFO_0004682 | |
| Disease | complement factor H-related protein 3 measurement | 2.49e-03 | 169 | 47 | 3 | EFO_0600056 | |
| Disease | sleep duration | 2.62e-03 | 362 | 47 | 4 | EFO_0005271 | |
| Disease | cardiac troponin I measurement | 2.79e-03 | 176 | 47 | 3 | EFO_0010071 | |
| Disease | attention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder | 3.01e-03 | 51 | 47 | 2 | EFO_0003756, EFO_0003888, MONDO_0002009, MONDO_0004985, MONDO_0005090 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| FLCHFLYLATFFWML | 846 | Q8IZF5 | |
| VTHYLYLCQFSWMLI | 5976 | Q8WXG9 | |
| NLSMLFCLTWPYILL | 246 | Q5I7T1 | |
| MFWCEFTASFLLFLN | 161 | Q8WXS4 | |
| WISMVDAFYQSLICF | 1196 | O94823 | |
| FTWLDFDYERKLMFC | 31 | A0A1B0GUU1 | |
| FSLFMALWAVLLLEY | 426 | Q6IWH7 | |
| YAGCMSQLFLFTWSL | 91 | Q8NGZ3 | |
| LIQYSWMCLSSFALS | 801 | P08235 | |
| VNILMCFWYLTSANI | 221 | Q8WWC4 | |
| RYMLLIFSLAFLASW | 81 | Q14500 | |
| MNYLKTWFVIDLLSC | 286 | Q8NCM2 | |
| LSNWMSICLYQYLKD | 1401 | O15031 | |
| IYFDACLFQMWLIHT | 96 | A6NMU1 | |
| LFSLLCAFFWMGLYL | 136 | Q14432 | |
| MNCFWEAAFRYSLKI | 96 | Q4G148 | |
| PMYFFLCNLSFLEIW | 56 | Q8NH79 | |
| FMWFFYALIPCLLTD | 16 | Q6UXL0 | |
| ILTMNNWYNFSLLLC | 256 | Q8TCU5 | |
| CYMLGLWSSIFSLNL | 571 | Q3MJ16 | |
| CIAWFTMEYLLRFLS | 236 | Q14721 | |
| SYIFIWLQLELCAMA | 6 | Q13145 | |
| SVFFWMLAKALLILY | 531 | Q8IZF7 | |
| FYWICIFFLLKISEM | 471 | Q9NY37 | |
| MRWLLLYYALCFSLS | 1 | P48740 | |
| FMTSLILFIWYCTCK | 186 | P56749 | |
| LLVLKVLWNDFLMCY | 276 | O60779 | |
| LNDLCASMWFTYLLL | 31 | Q6NUT3 | |
| LMFCLIALSTDFWFE | 16 | Q16617 | |
| LYRCALDIMIWNSVF | 86 | Q8NE79 | |
| FQWLLSTFILLYLMN | 26 | P42702 | |
| YYHWTLSFLGMSLCL | 616 | Q9H2X9 | |
| MNLWAIFCLLVLSSY | 646 | O60391 | |
| YFLCLIISFWNFKMR | 241 | P59543 | |
| RYMLLIFSLAFLASW | 81 | B7U540 | |
| AFTSLYCMLWFFLLD | 151 | P34981 | |
| YCMLWFFLLDLNIST | 156 | P34981 | |
| MPQTLAFCYLSLLWQ | 211 | Q53T94 | |
| LSQLWSCLFFIMLIF | 376 | P48065 | |
| FLAYIMFWLVLTSSC | 1021 | O94911 | |
| KSIFWNLMFFICLFT | 391 | Q5BKT4 | |
| CFDELQSEYLMLWLV | 191 | Q16281 | |
| SLFCIMFLCAQEWLT | 76 | Q8TBE1 | |
| LFCILQFLSMTWYSL | 126 | Q8WV19 | |
| QFELCERDTYMLLLW | 266 | Q03169 | |
| DLFQSMFLCALLLFW | 381 | Q9P2C4 | |
| MELWGAYLLLCLFSL | 1 | P05452 | |
| SWCSDMLSLYQEFLE | 61 | Q8N1Q8 | |
| LFQYCIMANYSWLLV | 221 | P47872 | |
| MLLAVLYCLLWSFQT | 1 | P14679 | |
| SDLQSLGYCMLKWLY | 371 | Q8IV63 | |
| LAWFEKMTCYLQLLF | 446 | Q8TCU3 | |
| RCLLYALNLLFWLMS | 11 | O95859 | |
| NMWITTCLNVFYFLK | 96 | Q9NYW2 |