Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	3.44e-15	431	68	18	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P NMBR	6.71e-11	884	68	19	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P NMBR ITGAL NOTCH2	2.09e-09	1353	68	21	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR9I1 OR10J3 OR13A1 OR10W1 OR5B21	7.27e-05	127	68	5	GO:0005549
GeneOntologyBiologicalProcess	sensory perception	OR10A3 OR1N1 OR10D3 OR51A7 UNC119 OR2A14 OR6B1 TSHZ3 EYS OR4S1 OR10J5 OR4Q2 ATXN7 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 LRP2 OR1F2P SLC38A8 OTOG	1.85e-15	1072	68	25	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	2.06e-15	432	68	18	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	7.37e-15	465	68	18	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	1.52e-14	485	68	18	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 EYS OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	2.51e-14	582	68	19	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	5.72e-14	524	68	18	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus	OR10A3 OR1N1 OR10D3 OR51A7 UNC119 OR2A14 OR6B1 EYS OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	9.97e-14	722	68	20	GO:0051606
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	1.19e-13	547	68	18	GO:0007606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P CCL15 NMBR	1.25e-08	1395	68	20	GO:0007186
GeneOntologyBiologicalProcess	peptidyl-tryptophan modification	DPY19L1 DPY19L2P2	1.59e-04	6	68	2	GO:0018211
GeneOntologyBiologicalProcess	protein C-linked glycosylation via tryptophan	DPY19L1 DPY19L2P2	1.59e-04	6	68	2	GO:0018317
GeneOntologyBiologicalProcess	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	DPY19L1 DPY19L2P2	1.59e-04	6	68	2	GO:0018406
GeneOntologyBiologicalProcess	protein C-linked glycosylation	DPY19L1 DPY19L2P2	1.59e-04	6	68	2	GO:0018103
Domain	Olfact_rcpt	OR10A3 OR1N1 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P	2.62e-12	393	63	15	IPR000725
Domain	7tm_1	OR10A3 OR1N1 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P NMBR	5.58e-10	677	63	16	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR10A3 OR1N1 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P NMBR	6.62e-10	685	63	16	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR10A3 OR1N1 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P NMBR	7.51e-10	691	63	16	PS50262
Domain	GPCR_Rhodpsn	OR10A3 OR1N1 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR6J1 OR10W1 OR5B21 OR1F2P NMBR	7.67e-10	692	63	16	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR10A3 OR1N1 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR10W1 OR5B21 NMBR	3.75e-08	670	63	14	IPR017452
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR13A1 OR6J1 OR10W1 OR5B21	1.95e-12	417	54	16	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR13A1 OR6J1 OR10W1 OR5B21 LRP2 OTOG	1.00e-11	636	54	18	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR10A3 OR1N1 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR5B21	1.98e-08	389	54	12	M14091
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR10W1 OR5B21 OR1F2P	4.27e-15	340	68	14	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR10W1 OR5B21 OR1F2P	4.27e-15	340	68	14	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR10W1 OR5B21 OR1F2P	4.82e-15	343	68	14	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR10J5 OR4C6 OR9I1 OR10J3 OR13A1 OR10W1 OR5B21 OR1F2P	5.43e-15	346	68	14	14611657
Pubmed	The human olfactory receptor gene family.	OR10A3 OR1N1 OR10D3 OR51A7 OR2A14 OR6B1 OR4S1 OR10J5 OR4Q2 OR4C6 OR9I1 OR10J3 OR10J6P OR13A1 OR10W1 OR1F2P	6.58e-15	541	68	16	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR10A3 OR1N1 OR2A14 OR6B1 OR4Q2 OR9I1 OR10J3 OR10J6P OR1F2P	4.71e-10	219	68	9	12213199
Pubmed	A dual role for talin in NK cell cytotoxicity: activation of LFA-1-mediated cell adhesion and polarization of NK cells.	TLN1 ITGAL	3.77e-06	2	68	2	19124737
Pubmed	Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg).	LRP2 TG	3.77e-06	2	68	2	9492085
Pubmed	A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.	TLN1 ITGAL	3.77e-06	2	68	2	15983060
Pubmed	Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin.	PRKN HERC5	1.13e-05	3	68	2	27534820
Pubmed	Expression of members of the putative olfactory receptor gene family in mammalian germ cells.	OR10A3 OR10D3 OR1F2P	1.59e-05	25	68	3	1370859
Pubmed	Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.	TLN1 ITGAL	2.25e-05	4	68	2	21454358
Pubmed	ATXN3, ATXN7, CACNA1A, and RAI1 Genes and Mitochondrial Polymorphism A10398G Did Not Modify Age at Onset in Spinocerebellar Ataxia Type 2 Patients from South America.	CACNA1A ATXN7	2.25e-05	4	68	2	25869926
Pubmed	The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance.	TLN1 ITGAL	2.25e-05	4	68	2	27760339
Pubmed	Molecular analysis of Spinocerebellar ataxias in Koreans: frequencies and reference ranges of SCA1, SCA2, SCA3, SCA6, and SCA7.	CACNA1A ATXN7	3.75e-05	5	68	2	11804332
Pubmed	The cytosolic protein talin induces an intermediate affinity integrin alphaLbeta2.	TLN1 ITGAL	3.75e-05	5	68	2	17591777
Pubmed	Spinocerebellar ataxias: microsatellite and allele frequency in unaffected and affected individuals.	CACNA1A ATXN7	3.75e-05	5	68	2	20069235
Pubmed	CAG repeats in Restless Legs syndrome.	CACNA1A ATXN7	5.62e-05	6	68	2	16389595
Pubmed	Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.	PRKN PKN1	5.62e-05	6	68	2	12716939
Pubmed	A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer.	KMT2A PKN1	7.86e-05	7	68	2	24793694
Pubmed	Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.	TLN1 ITGAL	1.34e-04	9	68	2	37267105
Pubmed	Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.	PRKN UBASH3A	1.34e-04	9	68	2	17599067
Pubmed	The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study.	CACNA1A ATXN7	1.68e-04	10	68	2	19259763
Pubmed	Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia.	CACNA1A ATXN7	1.68e-04	10	68	2	19235102
Pubmed	Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice.	UCP3 TG	2.05e-04	11	68	2	23690091
Pubmed	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	EYS PRKN	2.90e-04	13	68	2	22993228
Pubmed	Chromosomal location-dependent nonstochastic onset of odor receptor expression.	OR6B1 OR10J5	5.03e-04	17	68	2	20668191
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	TLN1 LRP2	5.65e-04	18	68	2	10827173
Pubmed	Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.	OR10J5 OR10J3	6.30e-04	19	68	2	22939635
Pubmed	Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.	TSHZ3 NETO1	6.30e-04	19	68	2	24315451
Pubmed	Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter.	TSHZ3 CCL15 NOTCH2	6.51e-04	86	68	3	35103284
Pubmed	Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.	DPY19L1 DPY19L2P2	7.00e-04	20	68	2	22028030
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	TLN1 LRP2 KMT2A OTOG	7.50e-04	208	68	4	33230847
Pubmed	The Repeat Expansion Diseases: The dark side of DNA repair.	CACNA1A ATXN7	9.28e-04	23	68	2	26002199
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	TSHZ3 ZNF644 KMT2A	1.10e-03	103	68	3	32744500
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	RCE1 UNC119 ATXN7 LRP2	1.14e-03	233	68	4	32290105
Pubmed	The sequence of the human genome.	EYS DPY19L1 DNAH17 KMT2A SLC47A2 SLC38A8	1.17e-03	603	68	6	11181995
Pubmed	Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.	SLC38A7 PRKN ZC3H7B	1.19e-03	106	68	3	33087821
Pubmed	Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.	TLN1 ITGAL	1.48e-03	29	68	2	23708969
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	TLN1 OTOG	1.69e-03	31	68	2	31550482
Pubmed	Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.	TLN1 F13A1	1.69e-03	31	68	2	14630798
Pubmed	The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.	ITGAL TG	1.69e-03	31	68	2	2165966
Cytoband	1q23.2	OR10J5 OR10J3 OR10J6P	1.97e-05	35	68	3	1q23.2
Cytoband	11q12.1	OR9I1 OR10W1 OR5B21	1.79e-03	161	68	3	11q12.1
Cytoband	7q35	OR2A14 OR6B1	3.05e-03	55	68	2	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	OR2A14 OR6B1	4.36e-03	66	68	2	chr7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr1q23	OR10J5 OR10J3 OR10J6P	4.66e-03	226	68	3	chr1q23
Cytoband	11q13.4	UCP3 PAAF1	5.59e-03	75	68	2	11q13.4
GeneFamily	Olfactory receptors, family 10	OR10A3 OR10D3 OR10J5 OR10J3 OR10J6P OR10W1	2.32e-08	66	49	6	157
Drug	butylate	CD33 KMT2A ITGAL UBASH3A	1.67e-06	30	66	4	CID000016181
Disease	serum amyloid P-component measurement	OR10J5 OR10J6P	2.60e-05	4	62	2	EFO_0008283
Disease	growth-regulated alpha protein measurement	OR10J5 OR10J3 OR10J6P	2.14e-04	55	62	3	EFO_0008146
Disease	chronic kidney disease, Proteinuria	CACNA1A KMT2A	2.36e-04	11	62	2	EFO_0003884, HP_0000093
Disease	autoimmune thyroiditis (is_implicated_in)	LRP2 TG	2.83e-04	12	62	2	DOID:7188 (is_implicated_in)
Disease	corpus callosum volume measurement	TLN1 SLC38A7 TG	1.24e-03	100	62	3	EFO_0010299
Disease	Vitiligo	ZC3H7B UBASH3A TG	1.27e-03	101	62	3	EFO_0004208
Disease	C-C motif chemokine 14 measurement	OR10J5 OR10J6P	1.47e-03	27	62	2	EFO_0008042
Disease	lumbar disc degeneration	EYS PRKN	1.59e-03	28	62	2	EFO_0004994

Protein segments in the cluster

Peptide	Gene	Start	Entry
FCGVVAHIQTPEDFF	TDRD1	496	Q9BXT4
FHSSFNCFDCGVIIG	CACNA1A	546	O00555
VFDCKFSPDGNHFAC	BRWD3	516	Q6RI45
PVVLNSFHFAADCCT	CCL15	41	Q16663
SFQEPPCEGNTFFCH	NETO1	286	Q8TDF5
CSGHVFVDSVPEFCL	INTS9	71	Q9NV88
HCAAQFFLFTICAGT	OR9I1	96	Q8NGQ6
FTGRHCETFVDVCPQ	NOTCH2	1296	Q04721
SLPFCQAQGIEHFFC	OR10W1	156	Q8NGF6
FPFCGPNEINHLFCE	OR10A3	166	P58181
PFCGPHEINHFFCEI	OR2A14	166	Q96R47
FCGSNEINHFFCDIP	OR5B21	166	A6NL26
FVGCFIFCWFPNHIL	NMBR	271	P28336
SGIVSFQCDCPLHFT	EYS	2121	Q5T1H1
SFCHICFELNIEGVP	EURL	31	Q9NYK6
VQEGLCVLVPCTFFH	CD33	31	P20138
AVFTCPLFFGVAHFH	RCE1	196	Q9Y256
CGFMHVIATFSLPFC	OR14L1P	156	Q8NHC6
GISPNACFAQEFFIH	OR51A7	91	Q8NH64
HLPFCGPNQVTFFCD	OR4Q2	166	P0C623
FCGPNEIDNFFCDVH	OR4S1	166	Q8NGB4
TVLCFFFNHGECTRV	DPY19L1	191	Q2PZI1
GHVCFQFDAPFVFAE	F13A1	421	P00488
NGDCSHFCFPVPNFQ	LRP2	981	P98164
TVVTFFCRPHNICTF	PRTN3	176	P24158
FGFCPAHDDFYLVVC	ATXN7	136	O15265
EGHVFDVNCCRFFPS	PAAF1	131	Q9BRP4
SFCADNTIPHIFCDV	OR1F2P	166	Q96R84
ENVQCCVIFSHFPFI	HERC5	621	Q9UII4
HFCVFAVSFPGQEAL	DNAH17	2586	Q9UFH2
HFPEFFGAVICANVT	AGA	296	P20933
CCCEGFPFHEVIQEF	GEN1	321	Q17RS7
GHVEFVYCQVCCEPF	KMT2A	1441	Q03164
KFHVIVAECAPFCQG	EIF2B2	186	P49770
ITVLCFFFNHGEATC	DPY19L2P2	86	Q6ZN68
CPEFVPGQAFCSHTE	LARP1B	316	Q659C4
FSNGVFGCNCDHAPF	CROT	316	Q9UKG9
DCVCQLFFFHFLGSI	OR10D3	96	Q8NH80
FCGPNVIIHFFCEVP	OR13A1	186	Q8NGR1
LFSCFNGGECVHPAF	OTOG	111	Q6ZRI0
GLPFCDAFVISHFFC	OR10J3	166	Q5JRS4
LPFCGTVVDHFFCDI	OR10J5	166	Q8NHC4
LPFCHTVVGHFFCDI	OR10J6P	166	Q8NGY7
FCVTGEIAHFFCDIT	OR1N1	166	Q8NGS0
FCGPNIIDHFICDLF	OR4C6	166	Q8NH72
CPGTSAEFFFKCGAH	PRKN	201	O60260
VFHVFEAICCVYGGV	SLC47A2	416	Q86VL8
DKFGFHTVTCCGFIP	FN3K	141	Q9H479
ICFGFQCHVSSVPVF	SLC38A7	251	Q9NVC3
LFGCFQTPEHVCFVM	PKN1	681	Q16512
AAFKPHGCFCVFNSI	ARHGAP5	651	Q13017
SCTDFSFHFPVCVQD	ITGAL	706	P20701
VFPTICFGFQCHEAA	SLC38A8	221	A6NNN8
ECTDTFQVHIQGFFC	PLPPR1	36	Q8TBJ4
PFCGSNIINHFFCDS	OR6J1	166	Q8NGC5
LSFCGPNVINHFFCD	OR6B1	166	O95007
NFPCHFVSAFGAGFC	UCP3	216	P55916
DFHFGFCIPSSKNTC	UNC119	176	Q13432
PFHCNACGKSFVVSS	ZNF668	391	Q96K58
IGFCNIIPSFFHCFT	SLC26A2	421	P50443
CGTGAFHPTCAFVEV	SEMA3B	131	Q13214
CEFAGFQCQIQFGPH	TLN1	236	Q9Y490
TGHPVFFCNDCASQI	TSHZ3	971	Q63HK5
CVFGTNCPKTFVQHA	ZNF644	501	Q9H582
AVCFVFTPNEFHAAG	TMEM129	16	A0AVI4
SVICSDHFAPACFDV	THAP10	51	Q9P2Z0
ACTSEGHFLPVQCFN	TG	686	P01266
EVFPHVTLCDFFTCE	UBASH3A	106	P57075
HAFCCFLTAVEDVNP	UNC79	1091	Q9P2D8
HQGIFTFLCEICFDS	ZC3H7B	546	Q9UGR2