Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionribosomal protein S6 kinase activity

RPS6KA2 RPS6KA3

4.26e-057292GO:0004711
GeneOntologyMolecularFunctionmagnesium ion binding

CDC42BPG ATP8B4 RPS6KA2 RPS6KA3

4.26e-04247294GO:0000287
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP8B4 ABCA7

7.52e-0428292GO:0140326
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP8B4 ABCA7

2.48e-0351292GO:0140303
GeneOntologyBiologicalProcesslysosomal protein catabolic process

AP5Z1 GGA3 VPS13A

4.96e-0624293GO:1905146
GeneOntologyBiologicalProcessprotein catabolic process in the vacuole

AP5Z1 GGA3 VPS13A

7.99e-0628293GO:0007039
GeneOntologyBiologicalProcessvacuolar transport

SPTBN5 HMGXB4 GGA3 VPS13A

1.30e-04187294GO:0007034
DomainPkinase_C

CDC42BPG RPS6KA2 RPS6KA3

2.52e-0537293IPR017892
DomainRibosomal_S6_kinase_II

RPS6KA2 RPS6KA3

3.48e-056292IPR016239
DomainPkinase_C

CDC42BPG RPS6KA2 RPS6KA3

3.71e-0542293PF00433
DomainAGC-kinase_C

CDC42BPG RPS6KA2 RPS6KA3

8.83e-0556293IPR000961
DomainAGC_KINASE_CTER

CDC42BPG RPS6KA2 RPS6KA3

8.83e-0556293PS51285
DomainS_TK_X

CDC42BPG RPS6KA2 RPS6KA3

8.83e-0556293SM00133
Domain-

PIDD1 LRRC3C AMIGO3 FBXL8 CARMIL3

1.23e-043212953.80.10.10
DomainL_dom-like

PIDD1 LRRC3C AMIGO3 FBXL8 CARMIL3

1.36e-04328295IPR032675
DomainLeu-rich_rpt

PIDD1 LRRC3C AMIGO3 CARMIL3

7.74e-04271294IPR001611
DomainLRR_8

PIDD1 LRRC3C AMIGO3

2.31e-03171293PF13855
DomainLeu-rich_rpt_typical-subtyp

PIDD1 LRRC3C AMIGO3

2.55e-03177293IPR003591
DomainLRR_TYP

PIDD1 LRRC3C AMIGO3

2.55e-03177293SM00369
DomainLRR

PIDD1 LRRC3C AMIGO3

3.65e-03201293PS51450
Domain-

EYA4 ATP8B4

4.42e-03642923.40.50.1000
DomainLRR_1

PIDD1 LRRC3C AMIGO3

4.64e-03219293PF00560
DomainHAD-like_dom

EYA4 ATP8B4

6.66e-0379292IPR023214
DomainLRRNT

LRRC3C AMIGO3

1.01e-0298292IPR000372
DomainLRRNT

LRRC3C AMIGO3

1.01e-0298292SM00013
DomainSer/Thr_kinase_AS

CDC42BPG RPS6KA2 RPS6KA3

1.75e-02357293IPR008271
DomainS_TKc

CDC42BPG RPS6KA2 RPS6KA3

1.78e-02359293SM00220
DomainPROTEIN_KINASE_ST

CDC42BPG RPS6KA2 RPS6KA3

1.82e-02362293PS00108
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

RPS6KA2 RPS6KA3

1.05e-055152MM15108
PathwayKEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING

RPS6KA2 RPS6KA3

1.58e-056152M47936
PathwayREACTOME_CREB_PHOSPHORYLATION

RPS6KA2 RPS6KA3

2.21e-057152MM14784
PathwayREACTOME_CREB_PHOSPHORYLATION

RPS6KA2 RPS6KA3

2.21e-057152M27096
PathwayREACTOME_RSK_ACTIVATION

RPS6KA2 RPS6KA3

2.21e-057152M27369
PathwayREACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS

RPS6KA2 RPS6KA3

1.10e-0415152MM15103
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA2 RPS6KA3

1.26e-0416152MM15477
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA2 RPS6KA3

1.60e-0418152M657
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA2 RPS6KA3

1.79e-0419152MM14780
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA2 RPS6KA3

2.41e-0422152M13408
PathwayREACTOME_L1CAM_INTERACTIONS

SPTBN5 RPS6KA2 RPS6KA3

2.60e-04121153M872
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

RPS6KA2 RPS6KA3

3.65e-0427152MM14779
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA2 RPS6KA3

3.93e-0428152MM15132
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

RPS6KA2 RPS6KA3

3.93e-0428152M837
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA2 RPS6KA3

4.83e-0431152M15195
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

RPS6KA2 RPS6KA3

6.16e-0435152MM15109
PathwayWP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING

RPS6KA2 RPS6KA3

6.52e-0436152M39908
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

RPS6KA2 RPS6KA3

6.52e-0436152M1315
PathwayREACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP

RPS6KA2 RPS6KA3

7.65e-0439152MM14900
PathwayREACTOME_RECYCLING_PATHWAY_OF_L1

RPS6KA2 RPS6KA3

1.21e-0349152M891
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

RPS6KA2 RPS6KA3

1.31e-0351152M7955
PathwayKEGG_MTOR_SIGNALING_PATHWAY

RPS6KA2 RPS6KA3

1.36e-0352152M7561
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

GNRH2 RPS6KA2 RPS6KA3

1.43e-03217153M18437
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

RPS6KA2 RPS6KA3

1.75e-0359152MM15128
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

RPS6KA2 RPS6KA3

1.87e-0361152M152
PathwayREACTOME_SIGNALING_BY_NTRK1_TRKA

RPS6KA2 RPS6KA3

1.99e-0363152MM14714
PathwaySIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES

RPS6KA2 RPS6KA3

2.25e-0367152M295
PathwayKEGG_LONG_TERM_POTENTIATION

RPS6KA2 RPS6KA3

2.45e-0370152M3115
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

RPS6KA2 RPS6KA3

2.52e-0371152M27382
PathwayREACTOME_SIGNALING_BY_NTRKS

RPS6KA2 RPS6KA3

2.80e-0375152MM14652
PathwayBIOCARTA_MAPK_PATHWAY

RPS6KA2 RPS6KA3

2.88e-0376152MM1433
PathwayWP_CYTOPLASMIC_RIBOSOMAL_PROTEINS

RPS6KA2 RPS6KA3

3.26e-0381152MM15911
PathwayBIOCARTA_MAPK_PATHWAY

RPS6KA2 RPS6KA3

3.26e-0381152M13863
PathwayREACTOME_MYD88_MAL_TIRAP_CASCADE_INITIATED_ON_PLASMA_MEMBRANE

RPS6KA2 RPS6KA3

3.59e-0385152MM14645
PathwayKEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION

RPS6KA2 RPS6KA3

3.59e-0385152M3578
PathwayWP_CYTOPLASMIC_RIBOSOMAL_PROTEINS

RPS6KA2 RPS6KA3

3.84e-0388152M39495
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

RPS6KA2 RPS6KA3

4.37e-0394152M2843
PathwayREACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE

RPS6KA2 RPS6KA3

4.83e-0399152MM14660
PathwayWP_THERMOGENESIS

RPS6KA2 RPS6KA3

5.72e-03108152M39746
PathwayREACTOME_MYD88_INDEPENDENT_TLR4_CASCADE

RPS6KA2 RPS6KA3

5.82e-03109152M29565
PathwayREACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE

RPS6KA2 RPS6KA3

5.82e-03109152M27012
PathwayREACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP

RPS6KA2 RPS6KA3

6.03e-03111152M27187
PathwayWP_SENESCENCEASSOCIATED_SECRETORY_PHENOTYPE_SASP

RPS6KA2 RPS6KA3

6.14e-03112152M48334
PathwayKEGG_OOCYTE_MEIOSIS

RPS6KA2 RPS6KA3

6.25e-03113152M16817
PathwayREACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE

RPS6KA2 RPS6KA3

6.46e-03115152M27013
PathwayREACTOME_CELLULAR_SENESCENCE

RPS6KA2 RPS6KA3

6.91e-03119152MM14901
PathwayREACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE

RPS6KA2 RPS6KA3

7.25e-03122152MM14640
PathwayKEGG_NEUROTROPHIN_SIGNALING_PATHWAY

RPS6KA2 RPS6KA3

7.71e-03126152M16763
PathwayWP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY

RPS6KA2 RPS6KA3

8.44e-03132152M39338
PathwayREACTOME_SIGNALING_BY_NTRKS

RPS6KA2 RPS6KA3

8.68e-03134152M3574
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

RPS6KA2 RPS6KA3 GGA3

9.03e-03418153MM15587
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

RPS6KA2 RPS6KA3

9.97e-03144152MM14501
PathwayREACTOME_TOLL_LIKE_RECEPTOR_CASCADES

RPS6KA2 RPS6KA3

1.15e-02155152MM14665
PathwayWP_INSULIN_SIGNALING

RPS6KA2 RPS6KA3

1.22e-02160152M39482
PathwayWP_INSULIN_SIGNALING

RPS6KA2 RPS6KA3

1.22e-02160152MM15956
PathwayWP_EGFEGFR_SIGNALING

RPS6KA2 RPS6KA3

1.25e-02162152M39334
PathwayREACTOME_TOLL_LIKE_RECEPTOR_CASCADES

RPS6KA2 RPS6KA3

1.37e-02170152M7494
PathwayWP_EGFR1_SIGNALING_PATHWAY

RPS6KA2 RPS6KA3

1.66e-02188152MM15828
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

RPS6KA2 RPS6KA3 GGA3

1.73e-02532153M27870
PathwayREACTOME_CELLULAR_SENESCENCE

RPS6KA2 RPS6KA3

1.81e-02197152M27188
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

RPS6KA2 RPS6KA3

1.95e-02205152M752
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

RPS6KA2 RPS6KA3

2.04e-02210152MM15043
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

RPS6KA2 RPS6KA3

2.06e-02211152MM14502
Pubmed

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit.

RPS6KA2 RPS6KA3

7.19e-07230211495723
Pubmed

Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.

RPS6KA2 RPS6KA3

2.16e-06330212016217
Pubmed

Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning.

RPS6KA2 RPS6KA3

2.16e-06330212393804
Pubmed

Human rsk isoforms: cloning and characterization of tissue-specific expression.

RPS6KA2 RPS6KA3

2.16e-0633028141249
Pubmed

The Clinical Implications of RSK1-3 in Human Breast Cancer.

RPS6KA2 RPS6KA3

2.16e-06330226977024
Pubmed

p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.

RPS6KA2 RPS6KA3

4.31e-06430221527514
Pubmed

RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.

RPS6KA2 RPS6KA3

4.31e-0643027623830
Pubmed

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.

RPS6KA2 RPS6KA3

4.31e-0643029770464
Pubmed

RSK2 is a modulator of craniofacial development.

RPS6KA2 RPS6KA3

7.18e-06530224416220
Pubmed

Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.

RPS6KA2 RPS6KA3

7.18e-0653029915826
Pubmed

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

RPS6KA2 RPS6KA3

7.18e-06530210480933
Pubmed

Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission.

RPS6KA2 RPS6KA3

7.18e-06530216217014
Pubmed

Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes.

RPS6KA2 RPS6KA3

7.18e-06530215526037
Pubmed

The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.

RPS6KA2 RPS6KA3

7.18e-06530237068088
Pubmed

Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.

RPS6KA2 RPS6KA3

7.18e-06530211160957
Pubmed

The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.

RPS6KA2 RPS6KA3

7.18e-06530215867353
Pubmed

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.

RPS6KA2 RPS6KA3

1.08e-05630212832467
Pubmed

NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.

RPS6KA2 RPS6KA3

1.08e-05630211175347
Pubmed

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

RPS6KA2 RPS6KA3

1.08e-05630216626623
Pubmed

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.

RPS6KA2 RPS6KA3

1.08e-0563028688081
Pubmed

Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.

RPS6KA2 RPS6KA3

1.08e-0563028939914
Pubmed

CREB is a regulatory target for the protein kinase Akt/PKB.

RPS6KA2 RPS6KA3

2.01e-0583029829964
Pubmed

P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.

RPS6KA2 RPS6KA3

2.58e-05930219555761
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

ADAM11 FCGBP ABCA7

5.26e-058430315203218
Pubmed

Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos.

RPS6KA2 RPS6KA3

6.50e-051430215305288
Pubmed

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

RPS6KA2 RPS6KA3

6.50e-05143029687510
Pubmed

Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors.

RPS6KA2 RPS6KA3

7.50e-051530227644329
Pubmed

Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.

RPS6KA2 RPS6KA3

1.35e-042030221421818
Cytoband20p13

SIGLEC1 GNRH2

2.04e-0310230220p13
CytobandEnsembl 112 genes in cytogenetic band chr20p13

SIGLEC1 GNRH2

2.95e-03123302chr20p13
GeneFamilyMitogen-activated protein kinase-activated protein kinases

RPS6KA2 RPS6KA3

4.55e-05111721156
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM11 BAIAP3 CARMIL3 GGA3

4.65e-06167304b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

FCGBP TTC7B ABCA7 GGA3

5.23e-06172304f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ATP8B4 TTC7B ABCA7 RPS6KA2

6.54e-0618230452eac2f892ea7f26731e0b21c578fd2665a1657a
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

BAIAP3 ABCA7 AP5Z1 RPS6KA2

9.01e-051813041535_UP
DrugBI D1870

RPS6KA2 RPS6KA3

9.16e-0511302ctd:C516541
Drugirinotecan HCl; Up 200; 100uM; MCF7; HT_HG-U133A

PIDD1 BAIAP3 ABCA7 AP5Z1

9.80e-051853047498_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

BAIAP3 ABCA7 AP5Z1 RPS6KA2

1.00e-041863047499_UP
DrugIsocorydine (+) [475-67-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ABCA7 GNRH2 AP5Z1 RPS6KA2

1.18e-041943042780_UP
DrugPentamidine isethionate [140-64-7]; Up 200; 6.8uM; PC3; HT_HG-U133A

PIDD1 ADAM11 BAIAP3 GGA3

1.18e-041943044573_UP
DrugChlorogenic acid [327-97-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A

PIDD1 BAIAP3 AP5Z1 GGA3

1.20e-041953043282_UP
DrugTheobromine [83-67-0]; Up 200; 22.2uM; MCF7; HT_HG-U133A

PIDD1 BAIAP3 RPS6KA2 GGA3

1.22e-041963044958_UP
DrugTolbutamide [64-77-7]; Down 200; 14.8uM; PC3; HT_HG-U133A

BAIAP3 ABCA7 RUBCN RPS6KA2

1.22e-041963044540_DN
DrugSulfaquinoxaline sodium salt [967-80-6]; Up 200; 12.4uM; MCF7; HT_HG-U133A

SPTBN5 SIGLEC1 MFSD13A BAIAP3

1.25e-041973046090_UP
DrugColistin sulfate [1264-72-8]; Down 200; 3uM; MCF7; HT_HG-U133A

MFSD13A AP5Z1 RPS6KA2 VPS13A

1.25e-041973044796_DN
DrugMerbromin [129-16-8]; Down 200; 5uM; MCF7; HT_HG-U133A

PIDD1 AP5Z1 RPS6KA2 VPS13A

1.25e-041973043439_DN
DrugGliquidone [33342-05-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A

BAIAP3 AP5Z1 RPS6KA2 VPS13A

1.30e-041993046004_UP
DrugCanrenoic acid potassium salt [2181-04-6]; Up 200; 10uM; MCF7; HT_HG-U133A

PIDD1 SIGLEC1 BAIAP3 AP5Z1

1.30e-041993046783_UP
DrugVigabatrin [60643-86-9]; Up 200; 31uM; MCF7; HT_HG-U133A

PIDD1 BAIAP3 ABCA7 AP5Z1

1.30e-041993045415_UP
DrugSB 202190; Up 200; 1uM; PC3; HT_HG-U133A

EYA4 ABCA7 AP5Z1 RPS6KA2

1.30e-041993047058_UP
DrugProxyphylline [603-00-9]; Up 200; 16.8uM; PC3; HT_HG-U133A

SIGLEC1 MFSD13A ABCA7 AP5Z1

1.30e-041993047290_UP
DrugCefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A

SPTBN5 BAIAP3 ABCA7 GGA3

1.30e-041993042235_UP
DrugArtemisinin [63968-64-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A

PIDD1 BAIAP3 AP5Z1 VPS13A

1.32e-042003047007_UP
Drugvaldecoxib; Up 200; 10uM; PC3; HT_HG-U133A

SPTBN5 MFSD13A AP5Z1 VPS13A

1.32e-042003046408_UP
DrugSaquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A

SIGLEC1 ADAM11 ABCA7 RPS6KA2

1.32e-042003046246_UP
DrugAD 288

RPS6KA2 RPS6KA3

1.51e-0414302CID000073553
Drugdiphenyl sulfide

SIGLEC1 RPS6KA3

1.51e-0414302CID000008766
DrugOvta

RPS6KA2 RPS6KA3

1.51e-0414302CID003081047
DrugR165481

RPS6KA2 RPS6KA3

1.99e-0416302CID005459348
DiseaseCoffin-Lowry syndrome (implicated_via_orthology)

RPS6KA2 RPS6KA3

5.59e-064292DOID:3783 (implicated_via_orthology)
Diseasesusceptibility to rubella infection measurement

TTC7B MFSD5

1.20e-0352292EFO_0008418
Diseasehearing impairment

EYA4 RPS6KA3

4.18e-0398292C1384666
DiseaseGlioblastoma Multiforme

CDC42BPG RPS6KA3

5.33e-03111292C1621958
Diseasestroke outcome severity measurement

TTC7B RPS6KA2

5.61e-03114292EFO_0009603
Diseasecranial vault morphology measurement

EYA4 GNRH2

6.30e-03121292EFO_0009278
Diseasebipolar I disorder

LRRC3C RPS6KA2

8.46e-03141292EFO_0009963

Protein segments in the cluster

PeptideGeneStartEntry
DLLPLLLGTAQHSDH

ARSL

436

P51690
SGFLSHLLLLSHLLR

BAIAP3

401

O94812
NFTLDLELNHHLLSS

ADAM11

96

O75078
DNLHLFSGHLSTLRL

AP5Z1

416

O43299
LIINGHSLAHALESD

ATP8B4

756

Q8TF62
HLHGLSATHLLTLDL

AMIGO3

176

Q86WK7
LILSTHHLDEAELLG

ABCA7

991

Q8IZY2
LDLLLALHHELSSGP

CDC42BPG

26

Q6DT37
EELDLSHNALAHLSG

LRRC3C

106

A6NJW4
NLLLETLLHHDGLLL

KIAA0825

811

Q8IV33
ELALALDHLHSLGII

RPS6KA3

176

P51812
GLSLNSHLSDLHLDL

CARMIL3

446

Q8ND23
SHLSDLHLDLSSCEL

CARMIL3

451

Q8ND23
LALGNSALHHLDALD

GGA3

506

Q9NZ52
AHLQLLGESLSLIGH

HMGXB4

526

Q9UGU5
ISSHSDLLALHQALE

EYA4

621

O95677
LGLHLASLSHAILEA

FBXL8

196

Q96CD0
LPFQLDSLLHAHLSG

FCGBP

3361

Q9Y6R7
LHASLLRSLDADSFH

C19orf44

611

Q9H6X5
LLLLTAHLGPSEAQH

GNRH2

11

O43555
GHLTEDLHLYSLNDL

RUBCN

841

Q92622
HALLADLALSAHDRT

MFSD13A

146

Q14CX5
HSLACLGLLVLHDSD

MFSD5

386

Q6N075
LSGLAHLAHLDLSFN

PIDD1

121

Q9HB75
HLAHLDLSFNSLETL

PIDD1

126

Q9HB75
LLHIHSADGQLHLLS

RTL1

1296

A6NKG5
HSLALLEDLEGHLLA

NHSL2

46

Q5HYW2
ELAESRGHALHASLL

SPTBN5

2136

Q9NRC6
FSSLDIHLHTEALLN

VPS13A

991

Q96RL7
LLALFHGEHLLATSL

SIGLEC1

826

Q9BZZ2
HLLHASALDLLHALA

nan

61

Q5BKY6
GDDANSLHLLALLLS

TTC7B

546

Q86TV6
LHLLLHGCDLELLTS

UHRF1BP1

1281

Q6BDS2
AELALALDHLHSLGI

RPS6KA2

166

Q15349