Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alcohol binding	NPC1 OSBPL2 OSBPL10 PTCH1 CYP2W1	2.73e-05	102	69	5	GO:0043178
GeneOntologyMolecularFunction	cholesterol binding	NPC1 OSBPL2 OSBPL10 PTCH1	4.81e-05	58	69	4	GO:0015485
GeneOntologyMolecularFunction	steroid binding	NPC1 OSBPL2 OSBPL10 PTCH1 NR1H4	9.71e-05	133	69	5	GO:0005496
GeneOntologyMolecularFunction	sterol binding	NPC1 OSBPL2 OSBPL10 PTCH1	1.07e-04	71	69	4	GO:0032934
GeneOntologyMolecularFunction	transition metal ion binding	NAALADL1 PLOD3 SUMF1 TRIM34 KDM4A PTCH1 MMP14 MMP16 TARS1 ALOX12B NR1H4 CYP2W1 L3MBTL4	1.89e-04	1189	69	13	GO:0046914
GeneOntologyMolecularFunction	dioxygenase activity	PLOD3 KDM4A JMJD1C ALOX12B	3.69e-04	98	69	4	GO:0051213
GeneOntologyMolecularFunction	aminopeptidase activity	NAALADL1 MMP14 MMP16	4.41e-04	43	69	3	GO:0004177
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM4A JMJD1C	1.04e-03	14	69	2	GO:0032454
GeneOntologyMolecularFunction	protein tyrosine kinase activity	CSF1R HIPK4 HIPK1 HIPK2	1.60e-03	145	69	4	GO:0004713
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH8 DNAH11	1.74e-03	18	69	2	GO:0008569
GeneOntologyMolecularFunction	phospholipid transporter activity	TMEM30B OSBPL2 OSBPL10	2.15e-03	74	69	3	GO:0005548
GeneOntologyMolecularFunction	zinc ion binding	NAALADL1 TRIM34 KDM4A PTCH1 MMP14 MMP16 TARS1 NR1H4 L3MBTL4	3.46e-03	891	69	9	GO:0008270
GeneOntologyMolecularFunction	metalloaminopeptidase activity	MMP14 MMP16	3.63e-03	26	69	2	GO:0070006
GeneOntologyBiologicalProcess	adaptive immune response	TRAV9-2 TRAV9-1 TRAV8-3 IGLV2-18 TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1 RAP1GAP2 IGLV7-43 IGLV3-16	1.43e-05	838	78	13	GO:0002250
GeneOntologyCellularComponent	T cell receptor complex	TRAV9-2 TRAV9-1 TRAV8-3 TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1	1.10e-08	163	79	9	GO:0042101
GeneOntologyCellularComponent	receptor complex	TRAV9-2 TRAV9-1 TRAV8-3 CSF1R TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1 PTPRQ GPR101 NR1H4	2.54e-07	581	79	13	GO:0043235
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	TRAV9-2 TRAV9-1 TRAV8-3 TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1	6.85e-06	350	79	9	GO:0098802
GeneOntologyCellularComponent	cytoplasmic stress granule	HIPK2 PUM2 GIGYF2 PUM1	4.82e-04	96	79	4	GO:0010494
GeneOntologyCellularComponent	plasma membrane protein complex	TRAV9-2 TRAV9-1 TRAV8-3 TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1 CDH6	7.30e-04	785	79	10	GO:0098797
MousePheno	mandibular cyst	ENAM PTCH1	1.46e-05	2	54	2	MP:0030220
MousePheno	jaw cyst	ENAM PTCH1	1.46e-05	2	54	2	MP:0030219
MousePheno	abnormal upper incisor morphology	ENAM PTCH1 MMP14	5.05e-05	19	54	3	MP:0030137
Domain	Ptc/Disp	NPC1 DISP3 PTCH1	3.18e-06	9	64	3	IPR003392
Domain	Patched	NPC1 DISP3 PTCH1	3.18e-06	9	64	3	PF02460
Domain	SSD	NPC1 DISP3 PTCH1	1.07e-05	13	64	3	IPR000731
Domain	SSD	NPC1 DISP3 PTCH1	1.07e-05	13	64	3	PS50156
Domain	Pumilio_RNA-bd	PUM2 PUM1	1.16e-05	2	64	2	IPR033712
Domain	PUM-HD	PUM2 PUM1	3.46e-05	3	64	2	IPR033133
Domain	PUF	PUM2 PUM1	3.46e-05	3	64	2	PF00806
Domain	PUM_HD	PUM2 PUM1	3.46e-05	3	64	2	PS50303
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	6.90e-05	4	64	2	IPR001313
Domain	DUF3377	MMP14 MMP16	6.90e-05	4	64	2	PF11857
Domain	Pept_M10A_metallopeptidase_C	MMP14 MMP16	6.90e-05	4	64	2	IPR021805
Domain	PUM	PUM2 PUM1	6.90e-05	4	64	2	PS50302
Domain	Pumilio	PUM2 PUM1	6.90e-05	4	64	2	SM00025
Domain	DHC_N1	DNAH8 DNAH11	3.19e-04	8	64	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH8 DNAH11	3.19e-04	8	64	2	IPR013594
Domain	Oxysterol-bd	OSBPL2 OSBPL10	7.46e-04	12	64	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL2 OSBPL10	7.46e-04	12	64	2	IPR018494
Domain	Oxysterol_BP	OSBPL2 OSBPL10	7.46e-04	12	64	2	PF01237
Domain	OSBP	OSBPL2 OSBPL10	7.46e-04	12	64	2	PS01013
Domain	Dynein_heavy_chain_D4_dom	DNAH8 DNAH11	1.02e-03	14	64	2	IPR024317
Domain	Dynein_HC_stalk	DNAH8 DNAH11	1.02e-03	14	64	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH8 DNAH11	1.02e-03	14	64	2	IPR013602
Domain	DHC_N2	DNAH8 DNAH11	1.02e-03	14	64	2	PF08393
Domain	MT	DNAH8 DNAH11	1.02e-03	14	64	2	PF12777
Domain	AAA_8	DNAH8 DNAH11	1.02e-03	14	64	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH8 DNAH11	1.02e-03	14	64	2	IPR011704
Domain	AAA_5	DNAH8 DNAH11	1.02e-03	14	64	2	PF07728
Domain	DHC_fam	DNAH8 DNAH11	1.18e-03	15	64	2	IPR026983
Domain	Pept_M10A_Zn_BS	MMP14 MMP16	1.18e-03	15	64	2	IPR021158
Domain	Dynein_heavy_dom	DNAH8 DNAH11	1.18e-03	15	64	2	IPR004273
Domain	Dynein_heavy	DNAH8 DNAH11	1.18e-03	15	64	2	PF03028
Domain	Hemopexin_CS	MMP14 MMP16	1.52e-03	17	64	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP14 MMP16	1.71e-03	18	64	2	IPR016293
Domain	PG_binding_1	MMP14 MMP16	2.11e-03	20	64	2	PF01471
Domain	Peptidoglycan-bd-like	MMP14 MMP16	2.11e-03	20	64	2	IPR002477
Domain	MetalloPept_cat_dom	MIPEP MMP14 MMP16	2.71e-03	81	64	3	IPR024079
Domain	-	MIPEP MMP14 MMP16	2.71e-03	81	64	3	3.40.390.10
Domain	Hemopexin-like_dom	MMP14 MMP16	2.79e-03	23	64	2	IPR000585
Domain	Hemopexin-like_repeat	MMP14 MMP16	2.79e-03	23	64	2	IPR018487
Domain	M10A_MMP	MMP14 MMP16	2.79e-03	23	64	2	IPR033739
Domain	Hemopexin	MMP14 MMP16	2.79e-03	23	64	2	PF00045
Domain	HEMOPEXIN	MMP14 MMP16	2.79e-03	23	64	2	PS00024
Domain	-	MMP14 MMP16	2.79e-03	23	64	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP14 MMP16	2.79e-03	23	64	2	PS51642
Domain	HX	MMP14 MMP16	2.79e-03	23	64	2	SM00120
Domain	Pept_M10A	MMP14 MMP16	2.79e-03	23	64	2	IPR021190
Domain	Peptidase_M10	MMP14 MMP16	3.04e-03	24	64	2	PF00413
Domain	JmjC	KDM4A JMJD1C	3.04e-03	24	64	2	PF02373
Domain	ZnMc	MMP14 MMP16	4.42e-03	29	64	2	SM00235
Domain	Peptidase_Metallo	MMP14 MMP16	4.42e-03	29	64	2	IPR006026
Domain	ZINC_PROTEASE	MIPEP MMP14 MMP16	4.63e-03	98	64	3	PS00142
Domain	JMJC	KDM4A JMJD1C	5.37e-03	32	64	2	PS51184
Domain	JmjC_dom	KDM4A JMJD1C	5.37e-03	32	64	2	IPR003347
Domain	JmjC	KDM4A JMJD1C	5.70e-03	33	64	2	SM00558
Pubmed	Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).	HIPK4 HIPK1 HIPK2	4.50e-08	4	79	3	25630557
Pubmed	The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.	TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1	8.38e-08	95	79	6	8650574
Pubmed	Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid.	NPC1 NR1H4	5.09e-06	2	79	2	19965601
Pubmed	Acetylcholinesterase level and molecular isoforms are altered in brain of Reelin Orleans mutant mice.	RELN ACHE	5.09e-06	2	79	2	14535959
Pubmed	Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.	XPC REV1	5.09e-06	2	79	2	19332561
Pubmed	Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation.	HIPK1 HIPK2	5.09e-06	2	79	2	20231426
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	5.09e-06	2	79	2	12459267
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	5.09e-06	2	79	2	29165587
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	5.09e-06	2	79	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	5.09e-06	2	79	2	26517885
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	5.09e-06	2	79	2	12667987
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	5.09e-06	2	79	2	12771951
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	5.09e-06	2	79	2	21397187
Pubmed	Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.	XPC REV1	5.09e-06	2	79	2	20007784
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	5.09e-06	2	79	2	31078383
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	5.09e-06	2	79	2	32753408
Pubmed	Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis.	MMP14 MMP16	5.09e-06	2	79	2	18022611
Pubmed	Translational regulation of acetylcholinesterase by the RNA-binding protein Pumilio-2 at the neuromuscular synapse.	ACHE PUM2	5.09e-06	2	79	2	21865157
Pubmed	Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.	XPC REV1	5.09e-06	2	79	2	28827409
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	5.09e-06	2	79	2	35338151
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	5.09e-06	2	79	2	32437472
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	5.09e-06	2	79	2	18776931
Pubmed	Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.	PUM2 PUM1	5.09e-06	2	79	2	32316190
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	RELN PCDHA5 CNTN2	8.98e-06	18	79	3	15570159
Pubmed	Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.	PUM2 PUM1	1.53e-05	3	79	2	30333515
Pubmed	Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.	PUM2 PUM1	1.53e-05	3	79	2	33397688
Pubmed	NORAD: Defender of the Genome.	PUM2 PUM1	1.53e-05	3	79	2	27157388
Pubmed	Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.	MMP14 MMP16	1.53e-05	3	79	2	18784838
Pubmed	OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.	OSBPL2 OSBPL10	1.53e-05	3	79	2	19554302
Pubmed	A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.	PUM2 PUM1	1.53e-05	3	79	2	25340845
Pubmed	PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.	PUM2 PUM1	1.53e-05	3	79	2	28232582
Pubmed	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.	PUM2 PUM1	1.53e-05	3	79	2	26724866
Pubmed	A cancer cell metalloprotease triad regulates the basement membrane transmigration program.	MMP14 MMP16	1.53e-05	3	79	2	16983145
Pubmed	Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.	MMP14 MMP16	1.53e-05	3	79	2	9119382
Pubmed	COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.	PUM2 PUM1	1.53e-05	3	79	2	38427913
Pubmed	Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.	HIPK1 HIPK2	1.53e-05	3	79	2	29793420
Pubmed	Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing.	PTCH1 CNTN2	1.53e-05	3	79	2	19946319
Pubmed	Pumilio facilitates miRNA regulation of the E2F3 oncogene.	PUM2 PUM1	1.53e-05	3	79	2	22345517
Pubmed	Presenilin 1 in migration and morphogenesis in the central nervous system.	RELN CDH6 CNTN2	2.50e-05	25	79	3	15163631
Pubmed	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	PUM2 PUM1	3.05e-05	4	79	2	30811992
Pubmed	Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland.	MMP14 MMP16	3.05e-05	4	79	2	15895410
Pubmed	A molecular genetic linkage map of mouse chromosome 18, including spm, Grl-1, Fim-2/c-fms, and Mbp.	NPC1 CSF1R	3.05e-05	4	79	2	1679325
Pubmed	Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).	MMP14 MMP16	3.05e-05	4	79	2	35062057
Pubmed	Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding.	MMP14 MMP16	3.05e-05	4	79	2	24970228
Pubmed	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.	HIPK1 HIPK2	3.05e-05	4	79	2	34785661
Pubmed	Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1.	HIPK1 HIPK2	3.05e-05	4	79	2	19250734
Pubmed	Target RNA motif and target mRNAs of the Quaking STAR protein.	PUM2 PUM1	3.05e-05	4	79	2	16041388
Pubmed	Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice.	RELN CNTN2	3.05e-05	4	79	2	16324103
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 HIPK1 RAP1GAP2 OTUD4 PUM2 GIGYF2 PUM1	4.01e-05	407	79	7	12693553
Pubmed	An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.	PUM2 PUM1	5.07e-05	5	79	2	27170441
Pubmed	Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons.	RELN CNTN2	5.07e-05	5	79	2	10399933
Pubmed	Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts.	CSF1R MMP14	5.07e-05	5	79	2	28914985
Pubmed	PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues.	PUM2 PUM1	5.07e-05	5	79	2	30269240
Pubmed	mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.	MMP14 MMP16	5.07e-05	5	79	2	12661033
Pubmed	Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells.	RELN CSF1R	5.07e-05	5	79	2	9852586
Pubmed	MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.	MMP14 MMP16	5.07e-05	5	79	2	29196321
Pubmed	The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence.	RELN PTCH1 CDH6	7.01e-05	35	79	3	20943929
Pubmed	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	PUM2 PUM1	7.60e-05	6	79	2	17768378
Pubmed	Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis.	PUM2 PUM1	7.60e-05	6	79	2	32198202
Pubmed	Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.	HIPK1 HIPK2	7.60e-05	6	79	2	16917507
Pubmed	The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.	MMP14 MMP16	7.60e-05	6	79	2	14645246
Pubmed	Regulation of area identity in the mammalian neocortex by Emx2 and Pax6.	ACHE CDH6	7.60e-05	6	79	2	10764649
Pubmed	Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.	HIPK1 HIPK2	7.60e-05	6	79	2	12529400
Pubmed	Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.	RELN CNTN2	7.60e-05	6	79	2	22351125
Pubmed	Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.	HIPK1 HIPK2	7.60e-05	6	79	2	20579985
Pubmed	Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.	HIPK1 HIPK2	7.60e-05	6	79	2	9748262
Pubmed	Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.	MMP14 MMP16	1.06e-04	7	79	2	19542530
Pubmed	Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation.	HIPK2 PTCH1	1.06e-04	7	79	2	12874272
Pubmed	Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.	MMP14 MMP16	1.06e-04	7	79	2	12879005
Pubmed	Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro.	PUM2 PUM1	1.06e-04	7	79	2	34678304
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH8 DNAH11	1.06e-04	7	79	2	9256245
Pubmed	Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.	PUM2 PUM1	1.06e-04	7	79	2	25100735
Pubmed	Membrane-type matrix metalloproteinases: Their functions and regulations.	MMP14 MMP16	1.06e-04	7	79	2	25794647
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH8 DNAH11	1.06e-04	7	79	2	31178125
Pubmed	Activation of C1r by proteolytic cleavage.	IGLV2-18 IGLV7-43 IGLV3-16	1.30e-04	43	79	3	1249422
Pubmed	The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.	OSBPL2 OSBPL10	1.41e-04	8	79	2	17428193
Pubmed	Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification.	SUMF1 PTCH1	1.41e-04	8	79	2	18832069
Pubmed	Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum.	PTCH1 CNTN2	1.41e-04	8	79	2	15183722
Pubmed	Physicochemical and functional characterization of the C1r subunit of the first complement component.	IGLV2-18 IGLV7-43 IGLV3-16	1.70e-04	47	79	3	814163
Pubmed	Recognition of immunoglobulins by Fcgamma receptors.	IGLV2-18 IGLV7-43 IGLV3-16	1.81e-04	48	79	3	11955599
Pubmed	Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators.	PUM2 PUM1	1.82e-04	9	79	2	35678316
Pubmed	Dorsal-to-Ventral Cortical Expansion Is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons.	RELN CNTN2	1.82e-04	9	79	2	31693895
Pubmed	ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.	OSBPL2 OSBPL10	1.82e-04	9	79	2	32734583
Pubmed	Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.	HIPK1 HIPK2	1.82e-04	9	79	2	16940173
Pubmed	Neural cell adhesion molecule is required for ventricular conduction system development.	ST8SIA2 CNTN2	2.27e-04	10	79	2	34100064
Pubmed	Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.	RELN CNTN2	2.27e-04	10	79	2	16407979
Pubmed	Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2.	ST8SIA2 CNTN2	2.27e-04	10	79	2	35115485
Pubmed	Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling.	PTCH1 DNAH11	2.27e-04	10	79	2	21098568
Pubmed	The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.	PUM2 PUM1	2.27e-04	10	79	2	23125361
Pubmed	Cellular functions of long noncoding RNAs.	PUM2 PUM1	2.27e-04	10	79	2	31048766
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP14 MMP16	2.76e-04	11	79	2	10949161
Pubmed	Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice.	ST8SIA2 CNTN2	2.76e-04	11	79	2	21273415
Pubmed	The Hedgehog receptor Patched1 regulates proliferation, neurogenesis, and axon guidance in the embryonic spinal cord.	PTCH1 CNTN2	2.76e-04	11	79	2	31634536
Pubmed	The genomic structure of human V beta 6 T cell antigen receptor genes.	TRBV7-3 TRBV7-1	2.76e-04	11	79	2	1660526
Pubmed	A forward genetic screen in mice identifies mutants with abnormal cortical patterning.	RELN CNTN2	2.76e-04	11	79	2	23968836
Pubmed	The OSBP-related protein family in humans.	OSBPL2 OSBPL10	2.76e-04	11	79	2	11483621
Pubmed	Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.	PTCH1 CNTN2	2.76e-04	11	79	2	25652406
Pubmed	Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.	ACHE PTCH1	2.76e-04	11	79	2	10521398
Pubmed	Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain.	RELN CNTN2	2.76e-04	11	79	2	20170731
Pubmed	Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves.	PTCH1 CNTN2	3.31e-04	12	79	2	26156498
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1 HIPK2	3.49e-08	185	79	7	chr7q34
Cytoband	7q34	TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1	4.72e-07	167	79	6	7q34
Cytoband	7q22	RELN PLOD3 ACHE	3.96e-05	38	79	3	7q22
Cytoband	6q24.1	ECT2L ADGRG6	3.91e-04	17	79	2	6q24.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	RELN PLOD3 ACHE TMEM225B	5.72e-04	219	79	4	chr7q22
Cytoband	22q11.2	IGLV2-18 IGLV7-43 IGLV3-16	1.19e-03	120	79	3	22q11.2
Cytoband	14q11	TRAV9-2 TRAV9-1 TRAV8-3	1.57e-03	132	79	3	14q11
Cytoband	Ensembl 112 genes in cytogenetic band chr14q11	TRAV9-2 TRAV9-1 TRAV8-3 MMP14	2.64e-03	332	79	4	chr14q11
Cytoband	1p13.2	CHIA HIPK1	2.88e-03	46	79	2	1p13.2
GeneFamily	T cell receptor beta locus at 7q34	TRBV13 TRBV7-9 TRBV7-7 TRBV7-6 TRBV7-3 TRBV7-1	1.58e-07	87	51	6	372
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL2 OSBPL10	5.06e-04	12	51	2	670
GeneFamily	Dyneins, axonemal	DNAH8 DNAH11	1.03e-03	17	51	2	536
GeneFamily	Immunoglobulin lambda locus at 22q11.2	IGLV2-18 IGLV7-43 IGLV3-16	2.02e-03	89	51	3	353
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP14 MMP16	2.07e-03	24	51	2	891
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4A JMJD1C	2.07e-03	24	51	2	485
GeneFamily	T-cell receptor alpha locus at 14q11.2	TRAV9-2 TRAV9-1 TRAV8-3	4.39e-03	117	51	3	371
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	FNIP2 EI24 HIPK2 MMP14 CDC34 SEC14L1	5.50e-07	168	79	6	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NRK PTPRQ DISP3 CNTN2 DNAH11	9.35e-07	184	79	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NRK PTPRQ DISP3 CNTN2 DNAH11	9.35e-07	184	79	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NRK PTPRQ DISP3 CNTN2 DNAH11	9.35e-07	184	79	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC44A5 OSBPL10 CDH6 NR1H4 ADGRG6 DNAH11	9.96e-07	186	79	6	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TMEM30B CHIA TRBV7-9 TRBV7-6 DISP3	6.67e-06	148	79	5	1186ee0d15244fee74c1d09df3967c1b69f8ddce
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC44A5 OSBPL10 CDH6 NR1H4 ADGRG6	1.23e-05	168	79	5	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLOD3 CSF1R HIPK1 TSPYL4 SEC14L1	1.54e-05	176	79	5	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC44A5 RGS9 ADGRG6 L3MBTL4 DNAH11	1.81e-05	182	79	5	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ST8SIA2 OSBPL10 CDH6 ADGRG6 L3MBTL4	2.01e-05	186	79	5	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC44A5 NRK OSBPL10 CDH6 DNAH11	2.01e-05	186	79	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC44A5 NRK HIPK2 OSBPL10 CDH6	2.07e-05	187	79	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RAP1GAP2 RGS9 TMEM225B MMP14 ADGRG6	2.23e-05	190	79	5	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ENAM CHIA NRK PTPRQ DNAH8	2.40e-05	193	79	5	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Cajal_Retzius-36\|World / Primary Cells by Cluster	TYRP1 RELN ACHE HIPK2 BCAN	2.52e-05	195	79	5	bc76a0586cc78f013cb96a2444e63e3c5daa3bc7
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Cajal_Retzius\|World / Primary Cells by Cluster	TYRP1 RELN ACHE HIPK2 BCAN	2.52e-05	195	79	5	424d8e2bc7f7e68f74219de06dbbb671c8b4c24c
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN GLCE RGS9 GPR101	4.90e-05	113	79	4	feb3c6a7723263d58e5ce020a0097fedfcf78ca8
Disease	Gastrointestinal Stromal Sarcoma	NPC1 HIPK1 HIPK2 PTCH1	4.27e-06	47	68	4	C3179349
Disease	Gastrointestinal Stromal Tumors	NPC1 HIPK1 HIPK2 PTCH1	5.48e-06	50	68	4	C0238198
Disease	Cis-4-decenoyl carnitine measurement	FNIP2 SLC44A5	5.21e-05	5	68	2	EFO_0022091
Disease	lung volume	PTCH1 ADGRG6	1.45e-04	8	68	2	EFO_0600046
Disease	renin measurement	NBEAL1 CNTN2	1.45e-04	8	68	2	EFO_0010616
Disease	octanoylcarnitine measurement	FNIP2 SLC44A5	1.86e-04	9	68	2	EFO_0021042
Disease	melanoma	TMEM30B TYRP1 KDM4A XPC TSPYL4	2.73e-04	248	68	5	C0025202
Disease	Basal cell carcinoma	XPC PTCH1	2.84e-04	11	68	2	C0007117
Disease	Parkinson's disease (implicated_via_orthology)	HIPK4 HIPK1 HIPK2 PTCH1	4.82e-04	157	68	4	DOID:14330 (implicated_via_orthology)
Disease	Ataxia	NPC1 PUM1	1.52e-03	25	68	2	C0004134
Disease	Ciliopathies	DNAH8 NR1H4 DNAH11	2.12e-03	110	68	3	C4277690

Protein segments in the cluster

Peptide	Gene	Start	Entry
WPPYTAGAQQYVSLD	ACHE	531	P22303
GRAFPEYPWNFNPYL	ERFL	221	A0A1W2PQ73
FGAPLPNYYSVDDRW	DISP3	401	Q9P2K9
YAWPFYNPVDVNALG	BRDT	291	Q58F21
FYNATNPLVTYWGPV	ADGRG6	561	Q86SQ4
QGWDAPQEVPYAYQG	CHIA	316	Q9BZP6
PQEVPYAYQGNVWVG	CHIA	321	Q9BZP6
SPGLQLFNVYPWLGA	CYP2W1	211	Q8TAV3
ILYVNPQDLGWNPYV	DNAH11	2316	Q96DT5
TQWGPQGYFYPIQIA	GLCE	201	O94923
GWFLPYTPTDNEYGA	ECT2L	126	Q008S8
EAWLQQYGYLPPGDL	MMP14	36	P50281
GRTYNDLAQYPVFPW	NBEAL1	2026	Q6ZS30
VWYGYPFQGFIENPV	OTUD4	861	Q01804
PDGSLYRFQTPYFWP	RGS9	96	O75916
YGVPWGVYPANLFQQ	PUM2	346	Q8TB72
GFYPQQPEEWYSPGI	NR1H4	81	Q96RI1
AYWYQQKPGQFPVLV	IGLV3-16	51	A0A075B6K0
YENWNPGQPDSYFLS	BCAN	766	Q96GW7
QLNYLGNYVPNGWTP	PLOD3	261	O60568
LGWPLYPGASEYDQI	HIPK2	396	Q9H2X6
GWPLYPGNNEYDQVR	HIPK4	211	Q8NE63
FLGWPLYPGASEYDQ	HIPK1	386	Q86Z02
EWLPSLGLPQYRSYF	PPFIA4	951	O75335
QLGLYPIIWQYPNGT	JMJD1C	856	Q15652
FGPLGWNIPYEFNSA	DNAH8	4066	Q96JB1
PLLELGWPAFYQGAY	FAM83D	111	Q9H4H8
YWKNLTFNPPIYGAD	KDM4A	121	O75164
QGYPNPENFSWTEYL	L3MBTL4	261	Q8NA19
YNRVSWYQQPPGTAP	IGLV2-18	51	A0A075B6J9
YPLSQWVAGLPGYEL	METTL25B	296	Q96FB5
TWYQYGFVQPQGPKA	POMGNT2	241	Q8NAT1
LQSTPPLYGWGQAAF	GPR101	161	Q96P66
GYNAWLSYELQPAPG	PCDHA5	601	Q9Y5H7
GYYPNWFQQKPGQAP	IGLV7-43	51	P04211
RWYQGFYPAGSQPVT	RELN	2106	P78509
SWQPPLEPNGIILYY	PTPRQ	916	Q9UMZ3
WVPPAQPNGLVFYYV	PTPRQ	1116	Q9UMZ3
YGVTPWGVYPASLFQ	PUM1	461	Q14671
VFPWLVLGGYDDQNY	NPC1	541	O15118
EAYPGLQGFNWTYLG	CSF1R	326	P07333
WYYKDPQGEIQGPFN	GIGYF2	536	Q6Y7W6
YNPLWAQLGDLYGAI	FNIP2	481	Q9P278
ERNWPYYFGFGLPLA	EI24	236	O14681
WYFSLPELFQGPVYL	TMEM30B	96	Q3MIR4
YPGLSYRWLLNEFPN	CNTN2	161	Q02246
EWNGYIPGFPILINF	ALOX12B	176	O75342
LPVIAQGPASLNYYW	SLC44A5	636	Q8NCS7
QGPASLNYYWVPLLT	SLC44A5	641	Q8NCS7
LQELPYGGWVAPNIY	DBR1	91	Q9UK59
YFLLLFWVGQPYPTL	CDH6	6	P55285
PYPNIRNFPSGRQWY	ENAM	321	Q9NRM1
TWTPPQVLQDYYAGG	SEC14L1	316	Q92503
SPPVYLTNEWVGYNA	NRK	881	Q7Z2Y5
LQGGFAPDYYDWGQQ	GPR137B	361	O60478
DGGRAELNPWPEYIY	TARS1	41	P26639
VPIWPFQCYNYGVLG	TRIM34	326	Q9BYJ4
YPQVILPQFGGYWIE	RAP1GAP2	101	Q684P5
GPLQFSVLWPYYVLG	TMEM225B	141	P0DP42
LSSYPNGYPFLFWEQ	PTCH1	1006	Q13635
NGYPFLFWEQYIGLR	PTCH1	1011	Q13635
YLYGFWPFPLDQNQN	ST8SIA2	311	Q92186
YFIQEGDGWVYFNPL	OSBPL10	746	Q9BXB5
TRWFYPGNNPYTGTP	OSBPL2	446	Q9H1P3
PGNNPYTGTPDWLYA	OSBPL2	451	Q9H1P3
PNGYGLYNIVGNAWE	SUMF1	286	Q8NBK3
APDNLGYTYEIQWPS	TYRP1	456	P17643
WEVAIFGPPNTYYEG	CDC34	41	P49427
VYWYQQGPGQDPQFL	TRBV13	61	A0A0A6YYD4
KFYGLPYVPNTAWQL	MIPEP	606	Q99797
FNVEVWLQKYGYLPP	MMP16	41	P51512
PLRPGANPQLEWQYY	REV1	456	Q9UBZ9
LYWYRQSLGQGPEFL	TRBV7-3	51	A0A075B6L6
SLFWYVQYPGEGLQL	TRAV9-2	51	A0A087WT02
ELWPNPLQYYLMGEG	TSPYL4	376	Q9UJ04
LYWYRQALGQGPEFL	TRBV7-6	51	A0A1B0GX31
LYWYQQALGQGPEFL	TRBV7-7	51	A0A0K0K1E9
SLFWYVQYPGEGPQL	TRAV9-1	51	A0A075B6T8
LYWYRQTLGQGPEFL	TRBV7-9	51	P04435
GLFGYWQTEEYQPPV	XPC	731	Q01831
LYWYRQSLGQGLEFP	TRBV7-1	51	A0A0A6YYK4
GPQVPLYWLGFVYAA	TMEM14EP	6	Q6UXP3
YLFWYVQSPGQGLQL	TRAV8-3	51	A0A0A6YYJ7
PGPGDLSIYDNWIRY	NAALADL1	476	Q9UQQ1