Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2 RYR3	1.31e-07	4	65	3	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2 RYR3	6.54e-07	6	65	3	GO:0048763
GeneOntologyMolecularFunction	transition metal ion binding	MYT1L FLG TRAF5 MYCBP2 MYT1 PEPD CRNN PEX10 PGLYRP2 XPNPEP1 HRNR FLG2 PLOD2 D2HGDH	2.28e-05	1189	65	14	GO:0046914
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2 RYR3	2.59e-05	18	65	3	GO:0015278
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR2 RYR3	1.39e-04	31	65	3	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR2 RYR3	1.68e-04	33	65	3	GO:0005217
GeneOntologyMolecularFunction	E-box binding	NEUROD2 ATOH1 NEUROD6	1.04e-03	61	65	3	GO:0070888
GeneOntologyBiologicalProcess	response to caffeine	IRS1 RYR1 RYR2 RYR3	4.55e-07	21	63	4	GO:0031000
GeneOntologyBiologicalProcess	cellular response to caffeine	RYR1 RYR2 RYR3	4.40e-06	11	63	3	GO:0071313
GeneOntologyBiologicalProcess	cellular response to alkaloid	ADCY8 RYR1 RYR2 RYR3	6.65e-06	40	63	4	GO:0071312
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	RYR1 RYR2 RYR3	9.65e-06	14	63	3	GO:0071415
GeneOntologyBiologicalProcess	response to calcium ion	NEUROD2 D2HGDH ADCY8 RYR1 RYR2 RYR3	9.69e-06	161	63	6	GO:0051592
GeneOntologyBiologicalProcess	response to alkaloid	IRS1 ADCY8 RYR1 RYR2 RYR3	4.00e-05	125	63	5	GO:0043279
GeneOntologyBiologicalProcess	response to magnesium ion	D2HGDH RYR2 RYR3	5.95e-05	25	63	3	GO:0032026
GeneOntologyBiologicalProcess	protein homooligomerization	KCNA3 SPAST SIGMAR1 ADCY8 RYR1 RYR3	6.22e-05	224	63	6	GO:0051260
GeneOntologyBiologicalProcess	cellular response to calcium ion	NEUROD2 ADCY8 RYR1 RYR3	1.52e-04	88	63	4	GO:0071277
GeneOntologyBiologicalProcess	skin epidermis development	FOXE1 FLG PUM2 HRNR FLG2	1.53e-04	166	63	5	GO:0098773
GeneOntologyBiologicalProcess	calcium-mediated signaling	DEFB1 NEUROD2 MYOZ1 RYR1 RYR2 RYR3	1.60e-04	266	63	6	GO:0019722
GeneOntologyBiologicalProcess	protein import into peroxisome matrix, receptor recycling	USP9X PEX10	1.91e-04	7	63	2	GO:0016562
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	RYR1 RYR2 RYR3	1.96e-04	37	63	3	GO:0014808
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by endoplasmic reticulum	RYR1 RYR2 RYR3	2.29e-04	39	63	3	GO:1903514
GeneOntologyBiologicalProcess	establishment of skin barrier	FLG HRNR FLG2	2.66e-04	41	63	3	GO:0061436
GeneOntologyBiologicalProcess	neutral lipid catabolic process	LPL PNPLA5 ABHD12	2.66e-04	41	63	3	GO:0046461
GeneOntologyBiologicalProcess	acylglycerol catabolic process	LPL PNPLA5 ABHD12	2.66e-04	41	63	3	GO:0046464
GeneOntologyBiologicalProcess	protein complex oligomerization	KCNA3 SPAST SIGMAR1 ADCY8 RYR1 RYR3	2.84e-04	296	63	6	GO:0051259
GeneOntologyBiologicalProcess	sarcoplasmic reticulum calcium ion transport	RYR1 RYR2 RYR3	3.29e-04	44	63	3	GO:0070296
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR FLG2	2.99e-07	5	66	3	GO:0036457
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	JAK1 TRAF5 RYR1 RYR2 RYR3	2.97e-04	185	66	5	GO:0009898
GeneOntologyCellularComponent	junctional membrane complex	RYR1 RYR3	3.48e-04	9	66	2	GO:0030314
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	RYR1 RYR2 RYR3	3.88e-04	45	66	3	GO:0033017
GeneOntologyCellularComponent	smooth endoplasmic reticulum	RYR1 RYR2 RYR3	4.14e-04	46	66	3	GO:0005790
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	4.35e-04	10	66	2	GO:0014701
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	JAK1 RYR1 RYR2	7.39e-04	56	66	3	GO:0031234
GeneOntologyCellularComponent	cytoplasmic side of membrane	JAK1 TRAF5 RYR1 RYR2 RYR3	7.99e-04	230	66	5	GO:0098562
GeneOntologyCellularComponent	Z disc	MYOZ1 RYR1 RYR2 RYR3	1.33e-03	151	66	4	GO:0030018
GeneOntologyCellularComponent	cornified envelope	FLG HRNR FLG2	1.36e-03	69	66	3	GO:0001533
GeneOntologyCellularComponent	calcium channel complex	RYR1 RYR2 RYR3	1.60e-03	73	66	3	GO:0034704
GeneOntologyCellularComponent	I band	MYOZ1 RYR1 RYR2 RYR3	1.88e-03	166	66	4	GO:0031674
GeneOntologyCellularComponent	perinuclear region of cytoplasm	JCAD SPAST PER2 TRAPPC12 PUM2 HRNR HEATR5B RYR1 RYR3	2.57e-03	934	66	9	GO:0048471
GeneOntologyCellularComponent	sarcoplasmic reticulum	RYR1 RYR2 RYR3	2.72e-03	88	66	3	GO:0016529
Domain	MIR	SDF2 RYR1 RYR2 RYR3	2.76e-08	10	65	4	PS50919
Domain	MIR	SDF2 RYR1 RYR2 RYR3	2.76e-08	10	65	4	PF02815
Domain	MIR	SDF2 RYR1 RYR2 RYR3	2.76e-08	10	65	4	SM00472
Domain	MIR_motif	SDF2 RYR1 RYR2 RYR3	2.76e-08	10	65	4	IPR016093
Domain	Ryanrecept_TM4-6	RYR1 RYR2 RYR3	4.02e-08	3	65	3	IPR009460
Domain	RyR	RYR1 RYR2 RYR3	4.02e-08	3	65	3	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2 RYR3	4.02e-08	3	65	3	IPR003032
Domain	RR_TM4-6	RYR1 RYR2 RYR3	4.02e-08	3	65	3	PF06459
Domain	Ryan_recept	RYR1 RYR2 RYR3	4.02e-08	3	65	3	IPR013333
Domain	RIH_assoc	RYR1 RYR2 RYR3	7.99e-07	6	65	3	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2 RYR3	7.99e-07	6	65	3	IPR013662
Domain	RIH_dom	RYR1 RYR2 RYR3	7.99e-07	6	65	3	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2 RYR3	7.99e-07	6	65	3	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2 RYR3	7.99e-07	6	65	3	IPR015925
Domain	-	RYR1 RYR2 RYR3	7.99e-07	6	65	3	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2 RYR3	7.99e-07	6	65	3	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2 RYR3	7.99e-07	6	65	3	PF08709
Domain	S_100	FLG CRNN HRNR FLG2	2.21e-06	27	65	4	PF01023
Domain	S100_Ca-bd_sub	FLG CRNN HRNR FLG2	2.57e-06	28	65	4	IPR013787
Domain	S_100	FLG CRNN HRNR FLG2	2.57e-06	28	65	4	SM01394
Domain	Filaggrin	FLG FLG2	1.19e-05	2	65	2	IPR003303
Domain	EF_hand_dom	FLG CRNN HRNR FLG2 RYR1 RYR2 RYR3	1.57e-05	232	65	7	IPR002048
Domain	-	FLG CRNN HRNR FLG2 RYR1 RYR2 RYR3	3.35e-05	261	65	7	1.10.238.10
Domain	MYT1	MYT1L MYT1	3.57e-05	3	65	2	PF08474
Domain	Myelin_TF	MYT1L MYT1	3.57e-05	3	65	2	IPR013681
Domain	PROLINE_PEPTIDASE	PEPD XPNPEP1	3.57e-05	3	65	2	PS00491
Domain	Peptidase_M24B_aminopep-P_CS	PEPD XPNPEP1	3.57e-05	3	65	2	IPR001131
Domain	EF-hand-dom_pair	FLG CRNN HRNR FLG2 RYR1 RYR2 RYR3	6.11e-05	287	65	7	IPR011992
Domain	Neurogenic_DUF	NEUROD2 NEUROD6	7.12e-05	4	65	2	IPR022575
Domain	Neuro_bHLH	NEUROD2 NEUROD6	7.12e-05	4	65	2	PF12533
Domain	Creatinase/Aminopeptidase_P_N	PEPD XPNPEP1	7.12e-05	4	65	2	IPR028980
Domain	TF_bHLH_NeuroD	NEUROD2 NEUROD6	7.12e-05	4	65	2	IPR016637
Domain	S100_CABP	FLG HRNR FLG2	1.11e-04	27	65	3	PS00303
Domain	-	PEPD XPNPEP1	1.18e-04	5	65	2	3.40.350.10
Domain	Creatin/AminoP/Spt16_NTD	PEPD XPNPEP1	1.18e-04	5	65	2	IPR029149
Domain	S100/CaBP-9k_CS	FLG HRNR FLG2	1.24e-04	28	65	3	IPR001751
Domain	EF_HAND_2	FLG CRNN HRNR FLG2 RYR2 RYR3	1.51e-04	231	65	6	PS50222
Domain	Znf_C2HC	MYT1L MYT1	1.77e-04	6	65	2	IPR002515
Domain	zf-C2HC	MYT1L MYT1	1.77e-04	6	65	2	PF01530
Domain	ZF_CCHHC	MYT1L MYT1	2.48e-04	7	65	2	PS51802
Domain	Pept_M24	PEPD XPNPEP1	4.23e-04	9	65	2	IPR000994
Domain	Peptidase_M24	PEPD XPNPEP1	4.23e-04	9	65	2	PF00557
Domain	-	PEPD XPNPEP1	4.23e-04	9	65	2	3.90.230.10
Domain	Ion_trans_dom	KCNA3 RYR1 RYR2 RYR3	6.69e-04	114	65	4	IPR005821
Domain	Ion_trans	KCNA3 RYR1 RYR2 RYR3	6.69e-04	114	65	4	PF00520
Domain	EF_Hand_1_Ca_BS	FLG CRNN HRNR FLG2	3.23e-03	175	65	4	IPR018247
Domain	SPRY	RYR1 RYR2 RYR3	3.46e-03	87	65	3	SM00449
Domain	SPRY	RYR1 RYR2 RYR3	4.30e-03	94	65	3	PF00622
Domain	SPRY_dom	RYR1 RYR2 RYR3	4.30e-03	94	65	3	IPR003877
Domain	B30.2/SPRY	RYR1 RYR2 RYR3	4.43e-03	95	65	3	IPR001870
Domain	B302_SPRY	RYR1 RYR2 RYR3	4.43e-03	95	65	3	PS50188
Domain	EF_HAND_1	FLG CRNN HRNR FLG2	5.57e-03	204	65	4	PS00018
Domain	EF-hand_8	RYR1 RYR2	6.23e-03	34	65	2	PF13833
Domain	-	NEUROD2 ATOH1 NEUROD6	6.50e-03	109	65	3	4.10.280.10
Domain	HLH	NEUROD2 ATOH1 NEUROD6	6.83e-03	111	65	3	PF00010
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR1 RYR2 RYR3	4.29e-06	11	43	3	M47958
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 RYR2 RYR3	7.40e-06	13	43	3	M39589
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 RYR2 RYR3	2.48e-05	19	43	3	M47760
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	18403125
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2 RYR3	6.53e-09	3	66	3	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2 RYR3	6.53e-09	3	66	3	12213830
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR FLG2	6.53e-09	3	66	3	23403047
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	10788707
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2 RYR3	6.53e-09	3	66	3	11159936
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2 RYR3	6.53e-09	3	66	3	7635066
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2 RYR3	2.61e-08	4	66	3	18206662
Pubmed	Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal.	NEUROD2 ATOH1 NEUROD6	2.61e-08	4	66	3	8938455
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2 RYR3	2.61e-08	4	66	3	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2 RYR3	2.61e-08	4	66	3	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2 RYR3	2.61e-08	4	66	3	9607712
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2 RYR3	2.61e-08	4	66	3	23482488
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	SIGMAR1 RYR2 RYR3	6.51e-08	5	66	3	33060591
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2 RYR3	6.51e-08	5	66	3	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2 RYR3	6.51e-08	5	66	3	19011160
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	23463619
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	19009018
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2 RYR3	1.30e-07	6	66	3	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2 RYR3	2.27e-07	7	66	3	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2 RYR3	2.27e-07	7	66	3	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2 RYR3	3.63e-07	8	66	3	19033399
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2 RYR3	3.63e-07	8	66	3	11784029
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYT1L JAK1 ATRN JCAD NEUROD2 SPAST DNAJC14 MYCBP2 CIAO3 USP9X NEUROD6 ABHD12 RYR3	7.44e-07	1285	66	13	35914814
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2 RYR3	1.42e-06	12	66	3	19095005
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	SHROOM3 SIGMAR1 USP9X ADCY8 RYR2 RYR3	1.98e-06	195	66	6	17110338
Pubmed	Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.	LPL NEUROD6	3.55e-06	2	66	2	21195353
Pubmed	Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice.	NEUROD2 NEUROD6	3.55e-06	2	66	2	9454850
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	3.55e-06	2	66	2	27678121
Pubmed	Murine filaggrin-2 is involved in epithelial barrier function and down-regulated in metabolically induced skin barrier dysfunction.	FLG2 HR	3.55e-06	2	66	2	22417302
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	3.55e-06	2	66	2	21531043
Pubmed	Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors.	MYT1L MYT1	3.55e-06	2	66	2	29291346
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	3.55e-06	2	66	2	16678258
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	3.55e-06	2	66	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	3.55e-06	2	66	2	9489997
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	3.55e-06	2	66	2	17259277
Pubmed	M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.	PEPD XPNPEP1	3.55e-06	2	66	2	35165443
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	3.55e-06	2	66	2	9192302
Pubmed	Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation.	JAK1 IRS1	3.55e-06	2	66	2	11162588
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	3.55e-06	2	66	2	12640042
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	3.55e-06	2	66	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	3.55e-06	2	66	2	26009179
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	3.55e-06	2	66	2	7556644
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	3.55e-06	2	66	2	32899693
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	3.55e-06	2	66	2	14592949
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	3.55e-06	2	66	2	8898078
Pubmed	Sex differences in obesity development in pair-fed neuronal lipoprotein lipase deficient mice.	LPL NEUROD6	3.55e-06	2	66	2	27689015
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	3.55e-06	2	66	2	15894801
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	3.55e-06	2	66	2	30542613
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	3.55e-06	2	66	2	14550562
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	3.55e-06	2	66	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	3.55e-06	2	66	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	3.55e-06	2	66	2	11673462
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	3.55e-06	2	66	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	3.55e-06	2	66	2	9817784
Pubmed	High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis.	LPL IRS1	3.55e-06	2	66	2	21986524
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	3.55e-06	2	66	2	25370123
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	3.55e-06	2	66	2	14985349
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	3.55e-06	2	66	2	15033925
Pubmed	MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system.	ATOH1 NEUROD6	3.55e-06	2	66	2	7744035
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	3.55e-06	2	66	2	18618700
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	3.55e-06	2	66	2	17118445
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	3.55e-06	2	66	2	24813994
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	3.55e-06	2	66	2	11500519
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SHROOM3 DNAJC14 PER2 MYCBP2 TRAPPC12 ZNRF1 IRS1 D2HGDH RYR1 PPP1R16A HR	6.87e-06	1105	66	11	35748872
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG HRNR FLG2	8.47e-06	21	66	3	19601998
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	1.06e-05	3	66	2	11171121
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	1.06e-05	3	66	2	18313230
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	1.06e-05	3	66	2	29730765
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.06e-05	3	66	2	24123915
Pubmed	Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression.	MYT1L MYT1	1.06e-05	3	66	2	30312684
Pubmed	Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of Hr(Hp) mice.	FOXE1 HR	1.06e-05	3	66	2	21777520
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.06e-05	3	66	2	23278119
Pubmed	Decrease of a Current Mediated by Kv1.3 Channels Causes Striatal Cholinergic Interneuron Hyperexcitability in Experimental Parkinsonism.	KCNA3 CHAT	1.06e-05	3	66	2	27568555
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	1.06e-05	3	66	2	28928464
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	1.06e-05	3	66	2	23454728
Pubmed	Developmental expression of PAM (protein associated with MYC) in the rodent brain.	MYCBP2 ADCY8	1.06e-05	3	66	2	12036515
Pubmed	Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice.	LPL NEUROD6	1.06e-05	3	66	2	28456865
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	1.06e-05	3	66	2	15024040
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	1.06e-05	3	66	2	32437351
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	1.06e-05	3	66	2	9986730
Pubmed	Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.	SPAST CHAT	1.06e-05	3	66	2	27773584
Pubmed	Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice.	ATOH1 NEUROD6	1.06e-05	3	66	2	11591219
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	2.12e-05	4	66	2	22100703
Interaction	SRI interactions	SIGMAR1 ATOH1 ITGA4 RYR2 RYR3	4.86e-06	78	64	5	int:SRI
Cytoband	1q21.3	FLG BNIPL HRNR FLG2	2.56e-05	117	66	4	1q21.3
Cytoband	2p25.3	MYT1L TRAPPC12	2.73e-04	17	66	2	2p25.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	FLG BNIPL CRNN HRNR FLG2	2.96e-04	404	66	5	chr1q21
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG CRNN HRNR FLG2	8.76e-10	7	42	4	1350
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2 RYR3	1.17e-08	3	42	3	287
GeneFamily	EF-hand domain containing	FLG CRNN HRNR FLG2 RYR2 RYR3	1.07e-05	219	42	6	863
GeneFamily	Zinc fingers C2H2C-type	MYT1L MYT1	1.58e-05	3	42	2	1261
GeneFamily	Basic helix-loop-helix proteins	NEUROD2 ATOH1 NEUROD6	2.12e-03	110	42	3	420
ToppCell	TCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-4\|TCGA-Stomach / Sample_Type by Project: Shred V9	FOXE1 FLG BNIPL CRNN MUC22	3.65e-06	157	66	5	2553ebf3e48de5bd184e77bd61114faa5a1d95ed
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L DEFB1 NEUROD2 NEUROD6 ADCY8	4.13e-06	161	66	5	69f5e759c0925daa37e0177a9cc3154842906bf6
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	JCAD NEUROD2 KIAA1549L NEUROD6 RYR2	8.34e-06	186	66	5	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	Nasal_Brush-Immune-Neutrophils\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZNF703 KLHDC2 POT1 D2HGDH S1PR4	8.34e-06	186	66	5	f5aa91dbef29f7efa2b9a728c6539d7541340cd4
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	FLG CRNN FLG2 MUC22	3.81e-05	127	66	4	d61b71572eab8a850ee8ce54323fb247525006e5
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1549L ADCY8 RYR2 RYR3	9.35e-05	160	66	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1549L ADCY8 RYR2 RYR3	9.35e-05	160	66	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Healthy_Control-Myeloid-Macrophages-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	NKPD1 PGLYRP2 IRS1 RYR2	9.58e-05	161	66	4	d0482666479530cd2fd0d229cbb59a1d79839477
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-4\|TCGA-Stomach / Sample_Type by Project: Shred V9	FOXE1 BNIPL CRNN MUC22	1.00e-04	163	66	4	6a12b802cb181f979ebc72674f3626fb855024e3
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2-Excitatory_Neuron.Slc17a7.Neurod2-C1ql3_(Nucleus_of_the_lateral_olfactory_tract_(LOT))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CILP2 NEUROD2 NEUROD6	1.02e-04	61	66	3	a9f5cbbe5683f2574130ffe8d375d693b9aa8f2d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Neuronal\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 NEUROD6	1.02e-04	61	66	3	0e5e74b82a61c1b544325f976fda3b217e5ce3d4
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2-Excitatory_Neuron.Slc17a7.Neurod2-C1ql3_(Nucleus_of_the_lateral_olfactory_tract_(LOT))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CILP2 NEUROD2 NEUROD6	1.02e-04	61	66	3	3797e1e122818211664847bb54730034af61430e
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L NEUROD2 NEUROD6 ADCY8	1.05e-04	165	66	4	6d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L NEUROD2 NEUROD6 ADCY8	1.05e-04	165	66	4	02cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAK1 MYCBP2 PGLYRP2 S1PR4	1.18e-04	170	66	4	90f7640f04672c800cb28aea50004b1bb0565e8a
ToppCell	Pericytes-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	MYT1L CILP2 KIAA1549L RYR2	1.21e-04	171	66	4	bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYT1L ITGA4 RYR1 RYR3	1.21e-04	171	66	4	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	TRAF5 POT1 NEURL4 RYR1	1.24e-04	172	66	4	58eaadf12366701103a0d1f133462c9495fedc30
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	TRAF5 POT1 NEURL4 RYR1	1.24e-04	172	66	4	4483073469001770015526303772fd54906c5d68
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHROOM3 TRAF5 ADCY8 RYR3	1.29e-04	174	66	4	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHROOM3 TRAF5 LPL ADCY8	1.35e-04	176	66	4	40993c41c1017b53039a337174fc56632b278609
ToppCell	facs-Heart-RA-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA3 PGLYRP2 ITGA4 S1PR4	1.38e-04	177	66	4	31201a72b7c1bdb0eff892b7072a35c80fd34727
ToppCell	facs-Heart-RA-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA3 PGLYRP2 ITGA4 S1PR4	1.38e-04	177	66	4	89d0131320cd96af8b0ee54f0f4d4771d17ef44e
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X MYT1 CHAT IRS1	1.41e-04	178	66	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_RORB_CARTPT\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHROOM3 TRAF5 LPL ADCY8	1.47e-04	180	66	4	5e78b29fa1cbdcf502fee3577e5b45766b90d1dc
ToppCell	severe-CD8+_T_naive\|severe / disease stage, cell group and cell class	ATRN DNAJC14 PGGHG POT1	1.47e-04	180	66	4	94fe530367b170777f4051a4034cff06d80dbb83
ToppCell	severe-CD8+_T_naive\|World / disease stage, cell group and cell class	ATRN DNAJC14 PGGHG POT1	1.50e-04	181	66	4	69eeeb7f326e230b07495d557f708fbe3312ac0a
ToppCell	droplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF703 LPL ABHD12 HR	1.57e-04	183	66	4	ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCell	droplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF703 LPL ABHD12 HR	1.60e-04	184	66	4	15ea746c77785120f69f9ab370fb7eb9b70692f8
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF703 LPL ABHD12 HR	1.60e-04	184	66	4	8fa30789c9d583188667cf375d2218e392dd40bc
ToppCell	droplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF703 LPL ABHD12 HR	1.60e-04	184	66	4	bd5e8fc453a6393b8778734a2c3c2f1281769bcd
ToppCell	droplet-Lung-nan-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF703 LPL ABHD12 HR	1.60e-04	184	66	4	3261d767d5e3d9e9fbac22ad73ca14e44beed89c
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF703 LPL ABHD12 HR	1.63e-04	185	66	4	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF703 LPL ABHD12 HR	1.67e-04	186	66	4	f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEFB1 SHROOM3 LPL RYR2	1.67e-04	186	66	4	8eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCell	droplet-Lung-nan-21m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF703 LPL ABHD12 HR	1.67e-04	186	66	4	8f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell	droplet-Lung-nan-18m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF703 LPL ABHD12 HR	1.70e-04	187	66	4	f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCell	droplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF703 LPL ABHD12 HR	1.70e-04	187	66	4	f20e7a1751694390f535ffb27b97e887220f8695
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	SHROOM3 TRAF5 RYR2 RYR3	1.74e-04	188	66	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEFB1 SHROOM3 LPL IRS1	1.74e-04	188	66	4	14e120b20e76baa07b6510a94f0c2dcdfdd52357
ToppCell	facs-Heart-RA-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CILP2 SHROOM3 RYR2 RYR3	1.77e-04	189	66	4	e4efbb0733b382f4c855f6653dcddf36e0f8df28
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEFB1 SHROOM3 LPL IRS1	1.77e-04	189	66	4	443359d90fafae0c1de6bdcce9e8c95df6ea4de8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	PGGHG MYCBP2 NEUROD6 RYR3	1.77e-04	189	66	4	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FADS1 ZNRF1 PLOD2 RYR3	1.77e-04	189	66	4	56156325cc36b1329bf483f81bb74f371ef15e20
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK-NK_CD56bright_CD16-\|bone_marrow / Manually curated celltypes from each tissue	JAK1 TRAF5 PGGHG ITGA4	1.77e-04	189	66	4	6e402fb3fc31e4cb541e3cd140d7a86c1083dbf5
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEFB1 SHROOM3 LPL IRS1	1.81e-04	190	66	4	68ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JAK1 JCAD MYCBP2 ITGA4	1.81e-04	190	66	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEFB1 SHROOM3 LPL IRS1	1.81e-04	190	66	4	010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 NEUROD6	1.81e-04	74	66	3	a50df7f4f7847b8aeff3fc6d521a69b50e05c719
ToppCell	NS-critical-d_07-13-Lymphoid-Treg\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TRAF5 KCNA3 ITGA4 S1PR4	1.88e-04	192	66	4	cd34defac6565d34db507918e791b09c79f7d1f8
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYT1L SHROOM3 FLG2 RYR3	2.00e-04	195	66	4	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYT1L SHROOM3 FLG2 RYR3	2.00e-04	195	66	4	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FADS1 LPL ITGA4 S1PR4	2.00e-04	195	66	4	c96755d2eb98112b703b5dbee9c88730ace7dcbf
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 NEUROD6 RYR2	2.04e-04	196	66	4	c9e7ac34993c873de4f198cdae77dcf099731532
ToppCell	367C-Myeloid-Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DEFB1 LPL PEPD S1PR4	2.08e-04	197	66	4	f5c21f0d363b5c298a2b82f6dff4f369397b5f25
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 LPL NEUROD6	2.12e-04	198	66	4	a0032e3ed259e39324a659490b9d340c5d9ba0fc
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 LPL NEUROD6	2.12e-04	198	66	4	60d8d3bbd754ffde41c50013d822667b185a9751
ToppCell	Skin\|World / Skin and Kidney Cells in Lupus Nephritis Patients.	FLG MYCBP2 BNIPL HR	2.16e-04	199	66	4	6be1340413ee868c610b6e3f58c65b493eb22bb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	MYT1L LPL NEUROD6 RYR2	2.16e-04	199	66	4	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 LPL NEUROD6	2.16e-04	199	66	4	0cd3e4e0fba000c996feaf012ff32198e1048c9d
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	MYT1L LPL NEUROD6 RYR2	2.16e-04	199	66	4	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 MYCBP2 NEUROD6	2.16e-04	199	66	4	77b4aa00f14b86ef5db0490be98787e063979541
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	MYT1L NEUROD2 LPL NEUROD6	2.16e-04	199	66	4	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 SPAST NEUROD6	2.20e-04	200	66	4	84e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Cortical_neuron\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ZNF703 NEUROD2 KIAA1549L NEUROD6	2.20e-04	200	66	4	7bba2ff09349c8db3d1ccf53520b12cbf7b0abac
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon\|organoid_Velasco_nature / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 LPL NEUROD6	2.20e-04	200	66	4	f6d6a2f4e2f51c292dfb97280353a49117798fc6
ToppCell	mLN-Dendritic_cell-cDC2\|Dendritic_cell / Region, Cell class and subclass	ZNF703 PER2 MYCBP2 PEX10	2.20e-04	200	66	4	e3f7852aaa26a9b3e626d85e40afde799e873045
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	MYT1L KIAA1549L MYCBP2 RYR2	2.20e-04	200	66	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 LPL NEUROD6	2.20e-04	200	66	4	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer\|World / Primary Cells by Cluster	MYT1L LPL NEUROD6 RYR2	2.20e-04	200	66	4	db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 LPL NEUROD6	2.20e-04	200	66	4	e4f0bb57be1112869c7068d0a789c2b802a442dd
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21\|World / Primary Cells by Cluster	MYT1L LPL NEUROD6 RYR2	2.20e-04	200	66	4	30a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 ZNRF1 NEUROD6	2.20e-04	200	66	4	5b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital\|World / Primary Cells by Cluster	MYT1L NEUROD2 LPL NEUROD6	2.20e-04	200	66	4	6bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19\|World / Primary Cells by Cluster	MYT1L NEUROD2 LPL NEUROD6	2.20e-04	200	66	4	c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	MYT1L NEUROD2 NEUROD6	2.46e-04	82	66	3	dadc97c81e44858f60687145316102fc10ecc13e
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Chat_(Habenular_cholinergic_cells)\|Thalamus / BrainAtlas - Mouse McCarroll V32	NEUROD2 CHAT NEUROD6	2.46e-04	82	66	3	51dd9ab3ddb26d3d3395d0c1a156a12a86caf89b
Drug	2-hydroxycarbazole	RYR1 RYR2 RYR3	2.22e-08	3	65	3	CID000093551
Drug	cis-diammineplatinum(II	RYR1 RYR2 RYR3	2.22e-08	3	65	3	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2 RYR3	2.22e-08	3	65	3	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2 RYR3	2.22e-08	3	65	3	CID005748312
Drug	8N3-cADPR	RYR1 RYR2 RYR3	2.22e-08	3	65	3	CID000127713
Drug	aminodantrolene	RYR1 RYR2 RYR3	2.22e-08	3	65	3	CID009570289
Drug	Gvapspat amide	LPL RYR1 RYR2 RYR3	8.06e-08	15	65	4	CID000125015
Drug	PCB74	RYR1 RYR2 RYR3	8.87e-08	4	65	3	CID000036218
Drug	148504-47-6	RYR1 RYR2 RYR3	8.87e-08	4	65	3	CID006444275
Drug	SC 38249	RYR1 RYR2 RYR3	8.87e-08	4	65	3	CID000134834
Drug	AC1L1U7A	RYR1 RYR2 RYR3	8.87e-08	4	65	3	CID000035682
Drug	MBED	RYR1 RYR2 RYR3	4.41e-07	6	65	3	CID000129958
Drug	chloro-m-cresol	RYR1 RYR2 RYR3	4.41e-07	6	65	3	CID000012008
Drug	AC1O528X	RYR1 RYR2 RYR3	4.41e-07	6	65	3	CID006475857
Drug	NSC114784	RYR1 RYR2 RYR3	4.41e-07	6	65	3	CID000419425
Drug	Azumoleno	RYR1 RYR2 RYR3	7.71e-07	7	65	3	CID000056259
Drug	Br2BAPTA	RYR1 RYR2 RYR3	7.71e-07	7	65	3	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR2 RYR3	7.71e-07	7	65	3	CID009547999
Drug	N-methyl-DL-aspartic acid	ATRN DNAJC14 PER2 SIGMAR1 ZBTB9 WDR18 CHAT ADCY8 RYR1 RYR2 RYR3	2.24e-06	655	65	11	CID000004376
Drug	PCB 95	RYR1 RYR2 RYR3	2.63e-06	10	65	3	CID000038012
Drug	PCB 66	RYR1 RYR2 RYR3	3.60e-06	11	65	3	CID000036185
Drug	R 478	RYR1 RYR2 RYR3	3.60e-06	11	65	3	CID000084223
Drug	8-amino-cADPR	RYR1 RYR2 RYR3	3.60e-06	11	65	3	CID003081323
Drug	Ryanodine	RYR1 RYR2 RYR3	4.80e-06	12	65	3	ctd:D012433
Drug	bimoclomol	IRS1 RYR1 RYR3	7.90e-06	14	65	3	CID009576891
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	8.03e-06	2	65	2	ctd:C005147
Drug	FPL 64176	RYR1 RYR2 RYR3	9.86e-06	15	65	3	CID000003423
Drug	AC1L9KQO	ATRN RYR1 RYR2 RYR3	1.16e-05	49	65	4	CID000447335
Drug	loperamide	SIGMAR1 IRS1 RYR1 RYR2 RYR3	1.26e-05	105	65	5	CID000003954
Drug	NSC7524	CHAT ADCY8 RYR1 RYR2 RYR3 S1PR4	1.34e-05	182	65	6	CID000005657
Drug	kazinol B	RYR1 RYR2 RYR3	1.47e-05	17	65	3	CID000480869
Drug	methylcoumarin	RYR1 RYR2 RYR3	1.76e-05	18	65	3	CID000007092
Drug	AC1L380G	RYR1 RYR2 RYR3	2.08e-05	19	65	3	CID000084698
Drug	AC1MW7VF	RYR1 RYR2 RYR3	2.08e-05	19	65	3	CID000414699
Drug	SK&F 82958	ADCY8 RYR1 RYR2	2.08e-05	19	65	3	ctd:C071262
Drug	TCNB	FADS1 MYOZ1 RYR1 RYR2 RYR3	2.30e-05	119	65	5	CID000008330
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	2.40e-05	3	65	2	CID000080262
Drug	flubendiamide	RYR1 RYR3	2.40e-05	3	65	2	CID011193251
Drug	IAA-94	KCNA3 RYR1 RYR2 RYR3	2.79e-05	61	65	4	CID000003667
Drug	indo-1/AM	RYR1 RYR2 RYR3	2.85e-05	21	65	3	CID000123918
Drug	succinylcholine	CHAT RYR1 RYR2 RYR3	3.38e-05	64	65	4	CID000005314
Drug	fura 2	ITGA4 RYR1 RYR2 RYR3	3.59e-05	65	65	4	CID000057054
Drug	phenytoin	KCNA3 SIGMAR1 PEPD RYR1 RYR2 RYR3	3.81e-05	219	65	6	CID000001775
Drug	pioglitazone	PER2 LPL PEPD IRS1 RYR1 RYR2 RYR3	3.95e-05	326	65	7	CID000004829
Drug	natrin	KCNA3 RYR1	4.80e-05	4	65	2	CID000019130
Drug	A-30	RYR1 RYR3	4.80e-05	4	65	2	CID003028528
Drug	Bastadin 10	RYR1 RYR3	4.80e-05	4	65	2	CID009589366
Drug	Sudan Red 7B	LPL NEURL4	4.80e-05	4	65	2	CID000061396
Drug	T0702	RYR1 RYR2 RYR3	4.88e-05	25	65	3	CID000005908
Drug	zaprinast	NEUROD2 ADCY8 RYR1 RYR2 RYR3	5.20e-05	141	65	5	CID000005722
Drug	Kn 04	KCNA3 RYR1 RYR3	5.51e-05	26	65	3	CID000131117
Drug	ethosuximide	SPAST RYR1 RYR2 RYR3	5.99e-05	74	65	4	CID000003291
Drug	A 68930	RYR1 RYR2	7.98e-05	5	65	2	ctd:C065380
Drug	2,4-xylidinothiazoline	RYR1 RYR2 RYR3	8.53e-05	30	65	3	CID000099296
Drug	LOPAC	RYR1 RYR2 RYR3	8.53e-05	30	65	3	CID000062696
Drug	M-HN	RYR1 RYR2 RYR3	9.43e-05	31	65	3	CID000015450
Drug	M3/M4	RYR1 RYR2 RYR3	1.04e-04	32	65	3	CID000486507
Drug	valproate	ATRN SHROOM3 CHAT XPNPEP1 RYR1 RYR2 RYR3	1.05e-04	381	65	7	CID000003121
Drug	CNS 1145	RYR1 RYR2 RYR3	1.14e-04	33	65	3	CID000190902
Drug	IHC-64	RYR1 RYR2 RYR3	1.14e-04	33	65	3	CID000162753
Drug	tetracaine	ADCY8 RYR1 RYR2 RYR3	1.18e-04	88	65	4	CID000005411
Drug	NSC692750	RYR1 RYR3	1.19e-04	6	65	2	CID000078910
Drug	cobalt-60	CIAO3 PEPD XPNPEP1 ADCY8 RYR1 RYR2 RYR3	1.21e-04	390	65	7	CID000061492
Drug	1,2-dichlorohexafluorocyclobutane	RYR1 RYR2 RYR3	1.61e-04	37	65	3	CID000009643
Drug	mag-fura-2	RYR1 RYR2 RYR3	1.61e-04	37	65	3	CID000123839
Drug	4-chloro-m-cresol	RYR1 RYR2 RYR3	1.61e-04	37	65	3	CID000001732
Drug	mag-indo-1	RYR1 RYR3	1.67e-04	7	65	2	CID000131881
Drug	CHEBI:564108	RYR1 RYR3	1.67e-04	7	65	2	CID006400637
Drug	AC1L98DX	RYR1 RYR2 RYR3	1.74e-04	38	65	3	CID000439957
Drug	AC1L1XPX	CHAT NEUROD6 ADCY8	1.74e-04	38	65	3	CID000011606
Drug	nitrendipine	ADCY8 RYR1 RYR2 RYR3	1.79e-04	98	65	4	CID000004507
Drug	NAADP	RYR1 RYR2 RYR3	1.89e-04	39	65	3	CID000123952
Drug	Vitamin K 3	JAK1 ATRN DEFB1 DNAJC14 GPBP1 PER2 USP9X PEPD ZNRF1 ITGA4 RYR1 PPP1R16A	1.90e-04	1249	65	12	ctd:D024483
Drug	Ethaverine hydrochloride [985-13-7]; Up 200; 9.2uM; HL60; HT_HG-U133A	NEUROD2 PGGHG CRNN RYR1 HR	1.96e-04	187	65	5	3037_UP
Drug	NSC406942	SIGMAR1 LPL CHAT ATOH1 ADCY8 RYR1 RYR2 RYR3	1.99e-04	565	65	8	CID000001115
Drug	dipyrone	RYR1 RYR2 RYR3	2.03e-04	40	65	3	CID000003110
Drug	baclofen	SIGMAR1 ADCY8 RYR1 RYR2 RYR3	2.17e-04	191	65	5	CID000002284
Drug	Dantrolene	RYR1 RYR2 RYR3	2.19e-04	41	65	3	ctd:D003620
Drug	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxy-3-methyl-5-oxohexanethioate	LPL RYR1	2.22e-04	8	65	2	CID016061173
Drug	noradrealine	PER2 SIGMAR1 LPL CHAT ADCY8 RYR1 RYR2 RYR3	2.24e-04	575	65	8	CID000000951
Drug	Labetalol hydrochloride [32780-64-6]; Up 200; 11uM; MCF7; HT_HG-U133A	MYOZ1 LPL CHAT RYR2 HR	2.27e-04	193	65	5	6809_UP
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HG-U133A	TRAF5 SIGMAR1 TRAPPC12 CIAO3 XPNPEP1	2.56e-04	198	65	5	421_DN
Drug	Furosemide [54-31-9]; Up 200; 12uM; MCF7; HT_HG-U133A	PER2 FAM120C LPL CHAT RYR1	2.62e-04	199	65	5	6841_UP
Drug	Acrylamide	PER2 MYOZ1 CHAT RYR1 RYR3	2.62e-04	199	65	5	ctd:D020106
Drug	Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A	PGGHG MYT1 CHAT ITGA4 HR	2.62e-04	199	65	5	6080_UP
Drug	escina	RYR1 RYR2 RYR3	2.71e-04	44	65	3	CID006433489
Drug	lactosyl lysosphingolipid	RYR1 RYR3	2.85e-04	9	65	2	CID006439268
Drug	FLA 365	RYR1 RYR3	2.85e-04	9	65	2	CID000072776
Drug	4,4'-dithiodipyridine	RYR1 RYR2 RYR3	2.89e-04	45	65	3	CID000075846
Drug	ts M	RYR1 RYR2 RYR3	3.50e-04	48	65	3	CID000428025
Drug	AC1N38XE	RYR1 RYR3	3.56e-04	10	65	2	CID004060965
Drug	EDAC	SIGMAR1 CRNN PGLYRP2 ADCY8	3.64e-04	118	65	4	CID000015908
Drug	Trp-Trp	RYR1 RYR2 RYR3	3.73e-04	49	65	3	CID000088656
Drug	AC1L1KS5	DEFB1 LPL ADCY8 RYR1 RYR2 RYR3	3.80e-04	334	65	6	CID000005631
Drug	manganese	LPL PEPD NKPD1 XPNPEP1 ITGA4 ADCY8 RYR1 RYR2 RYR3	3.94e-04	791	65	9	CID000023930
Drug	etridiazole	RYR1 RYR2 RYR3	3.95e-04	50	65	3	CID000017432
Drug	2,3,6,2',3',6'-hexachlorobiphenyl	RYR1 RYR2	4.34e-04	11	65	2	ctd:C010498
Drug	carbanilide	ITGA4 RYR1	4.34e-04	11	65	2	CID000007595
Drug	Tyr-pro-leu-gly	PEPD XPNPEP1	4.34e-04	11	65	2	CID003081038
Drug	tectoridin	RYR1 RYR2	4.34e-04	11	65	2	CID005281810
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2 RYR3	9.28e-09	3	63	3	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2 RYR3	9.28e-09	3	63	3	DOID:8545 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	FADS1 RYR1 RYR2 RYR3 HR	6.17e-05	195	63	5	DOID:1574 (implicated_via_orthology)
Disease	eosinophil count	JAK1 CILP2 FADS1 MYT1 LPL POT1 ZBTB9 XPNPEP1 ITGA4 MUC22 D2HGDH S1PR4	6.31e-05	1488	63	12	EFO_0004842
Disease	cancer antigen 125 measurement	CIAO3 D2HGDH	2.00e-04	10	63	2	EFO_0010603
Disease	free cholesterol to total lipids in very large HDL percentage	FADS1 NEUROD2 LPL	2.25e-04	55	63	3	EFO_0022288
Disease	susceptibility to mononucleosis measurement	MYT1L ZBTB9 RYR2	4.40e-04	69	63	3	EFO_0008403
Disease	level of Triacylglycerol (53:3) in blood serum	FADS1 LPL	4.63e-04	15	63	2	OBA_2045165
Disease	high density lipoprotein cholesterol measurement, metabolic syndrome	FADS1 LPL	4.63e-04	15	63	2	EFO_0000195, EFO_0004612
Disease	diacylglycerol 36:2 measurement	FADS1 LPL	5.28e-04	16	63	2	EFO_0010355
Disease	Lipidemias	LPL IRS1	5.98e-04	17	63	2	C1706412
Disease	Hyperlipidemia	LPL IRS1	5.98e-04	17	63	2	C0020473
Disease	parental longevity	MYT1L JCAD SHROOM3 LPL MUC22 RYR3	6.48e-04	494	63	6	EFO_0007796
Disease	diacylglycerol 36:3 measurement	FADS1 LPL	6.71e-04	18	63	2	EFO_0020062
Disease	pulmonary hypertension (biomarker_via_orthology)	RYR1 RYR2 RYR3	6.78e-04	80	63	3	DOID:6432 (biomarker_via_orthology)
Disease	childhood onset asthma	FLG NEUROD2 ZBTB9 HRNR D2HGDH	7.41e-04	334	63	5	MONDO_0005405
Disease	monocyte percentage of leukocytes	JAK1 FADS1 KCNA3 PEPD ITGA4 NEURL4 S1PR4	9.24e-04	731	63	7	EFO_0007989
Disease	lymphocyte count	JAK1 JCAD CILP2 SPAST PEPD PGLYRP2 ITGA4 MUC22 NEURL4 S1PR4	1.01e-03	1464	63	10	EFO_0004587
Disease	level of Sphingomyelin (d40:2) in blood serum	FADS1 MYT1	1.10e-03	23	63	2	OBA_2045181
Disease	obesity (implicated_via_orthology)	LPL PUM2 IRS1 PNPLA5	1.17e-03	215	63	4	DOID:9970 (implicated_via_orthology)
Disease	triglyceride measurement, alcohol drinking	FADS1 LPL PEPD	1.26e-03	99	63	3	EFO_0004329, EFO_0004530
Disease	diacylglycerol 34:2 measurement	FADS1 LPL	1.30e-03	25	63	2	EFO_0010353
Disease	triglyceride measurement, alcohol consumption measurement	FADS1 LPL PEPD	1.33e-03	101	63	3	EFO_0004530, EFO_0007878
Disease	Absence Seizures	SIGMAR1 CHAT D2HGDH	1.37e-03	102	63	3	C4316903
Disease	Tonic Seizures	SIGMAR1 CHAT D2HGDH	1.37e-03	102	63	3	C0270844
Disease	level of Sterol ester (27:1/18:2) in blood serum	FADS1 NKPD1	1.41e-03	26	63	2	OBA_2045194
Disease	Myoclonic Seizures	SIGMAR1 CHAT D2HGDH	1.45e-03	104	63	3	C4317123
Disease	Tonic - clonic seizures	SIGMAR1 CHAT D2HGDH	1.45e-03	104	63	3	C0494475
Disease	age at assessment, lateral ventricle volume change measurement	LPL ADCY8	1.52e-03	27	63	2	EFO_0008007, EFO_0021502
Disease	reticulocyte count	ATRN USP9X LPL PEPD IRS1 ITGA4 ADCY8 S1PR4	1.66e-03	1045	63	8	EFO_0007986
Disease	coronary artery disease, factor VII measurement	JCAD LPL MUC22	1.75e-03	111	63	3	EFO_0001645, EFO_0004619
Disease	triacylglycerol 56:7 measurement	FADS1 LPL	1.76e-03	29	63	2	EFO_0010434
Disease	basophil count, eosinophil count	JAK1 FADS1 D2HGDH S1PR4	1.77e-03	241	63	4	EFO_0004842, EFO_0005090
Disease	factor VIII measurement, coronary artery disease	JCAD LPL MUC22	1.84e-03	113	63	3	EFO_0001645, EFO_0004630
Disease	factor XI measurement, coronary artery disease	JCAD LPL MUC22	1.93e-03	115	63	3	EFO_0001645, EFO_0004694
Disease	eicosapentaenoic acid measurement	FADS1 MUC22	2.00e-03	31	63	2	EFO_0007760
Disease	triacylglycerol 54:3 measurement	FADS1 LPL	2.00e-03	31	63	2	EFO_0010421
Disease	von Willebrand factor measurement, coronary artery disease	JCAD LPL MUC22	2.08e-03	118	63	3	EFO_0001645, EFO_0004629

Protein segments in the cluster

Peptide	Gene	Start	Entry
TEQRFIHGHRGGSGS	ADCY8	46	P40145
GGNFLTGLGHRSDHY	DEFB1	21	P60022
GHPGSSRGGRQGSYH	FLG	1491	P20930
HPGSSRGGRQGSHYE	FLG	1816	P20930
GHPGSSRRGRQGSHY	FLG	3436	P20930
GSGENSAVLHYGHAG	PEPD	246	P12955
GEHLGRGTRTHIYSG	JAK1	586	P23458
HLGGLTNGSGRYISA	PUM2	651	Q8TB72
YRGGLRSAAGGALHS	PEX10	21	O60683
ILYLHGNAGTRGGDH	ABHD12	171	Q8N2K0
TGDTTRHGHSGYGQS	FLG2	2301	Q5D862
LYGAHHSGGASLRTL	DNAJC14	11	Q6Y2X3
GSGTFHSLGNALVHG	MUC22	1716	E2RYF6
TENINHRGGYHGGSS	GPBP1	81	Q86WP2
HTQGALVQGGYGHSS	ATRN	491	O75882
GSQHGHTGRQVSSPY	JCAD	531	Q9P266
VLSHGGYHGDGLNAV	BNIPL	201	Q7Z465
AYGVSPHRGHLGTKN	HR	991	O43593
GYGSLGSNGSHEHLM	PER2	481	O15055
LGYSLGAHAAGIAGS	LPL	156	P06858
VGAHTLGHNSRGFGV	PGLYRP2	466	Q96PD5
HGSGSRQSLGHGRQG	HRNR	286	Q86YZ3
SYGQHGSGSRQSLGH	HRNR	516	Q86YZ3
PASSGGAHTLVNHGY	KCNA3	26	P22001
SAGHAGQSRHQEAYG	KIAA1549L	1566	Q6ZVL6
HVSGVYNGAGGDTHR	PGGHG	41	Q32M88
GHYILSRGGNGHRCT	IRS1	481	P35568
AGKGQHYEGSSHRQS	CRNN	126	Q9UBG3
GGKHHDSRISGGYEN	PLOD2	591	O00469
GHSLALGCLHRYVGG	HEATR5B	911	Q9P2D3
ALGAYSGGAGPIRHH	FAM120C	71	Q9NX05
HHLRTAASYEGGAGN	ATOH1	236	Q92858
RHPGGSRVISHYAGQ	FADS1	51	O60427
LGYSVGAGHFRSQHT	ITGA4	251	P13612
RVLYLFGGHHSRGNT	KLHDC2	101	Q9Y2U9
VLHYNHSGRLAGRGG	S1PR4	26	O95977
SSQGGGHRTLLYGHA	RYR1	91	P21817
QGGGHRTLLYGHAIL	RYR2	106	Q92736
GAGGSDLRFHQLHGS	NEURL4	711	Q96JN8
GYGHLGDGNLHLNVT	D2HGDH	431	Q8N465
YAGGEGIQHASHGTA	GARIN3	231	Q8TC56
VGVLVHSGQASGGHY	USP9X	1866	Q93008
LGGASAGAYHARHAA	FOXE1	346	O00358
LYLSLGGHALGHGSP	NKPD1	136	Q17RQ9
NLSFSGAGYLGAHHV	PNPLA5	11	Q7Z6Z6
LEFHLHGGTSYGRGI	POT1	261	Q9NUX5
HNGRVGGSPVRHLYS	PPP1R16A	411	Q96I34
LFGTALGSRGHSGRY	SIGMAR1	106	Q99720
GGSGFGHNYRPHRTV	SHROOM3	801	Q8TF72
YGQHGQLGHGDVNSR	MYCBP2	966	O75592
HSGANLLTYRGGQAG	WDR18	26	Q9BV38
GSAGLSGHHRAPSYS	SPAST	256	Q9UBP0
LHSHDVRYGSGSGQQ	SDF2	41	Q99470
AYLNGDGSGRGSHLS	TRAF5	446	O00463
HRGGGSGGYLEHVFR	CIAO3	311	Q9H6Q4
HNAGGSHPRTRGQLY	CILP2	956	Q8IUL8
THRALQLLHGGGYSK	CHAT	401	P28329
CLGGYHGASHLGGSS	ZNF703	381	Q9H7S9
LDYLHGTGHGVGSFL	XPNPEP1	481	Q9NQW7
AHGQGYGKSGLLTSH	TRAPPC12	406	Q8WVT3
QGGGHRTLLYGHAVL	RYR3	96	Q15413
GGISARGGNSYHALL	ZBTB9	146	Q96C00
GKGFSGYSSLQAHHR	ZNF112	811	Q9UJU3
TGGGHHRDGMLYLGS	ZNRF1	106	Q8ND25
QYGSDQQHHLGSGSG	MYOZ1	126	Q9NP98
GQGHITGKYASHRSA	MYT1L	961	Q9UL68
GSGHITGNYASHRSL	MYT1	851	Q01538
GLGGGAAHALRTHGY	NEUROD2	256	Q15784
GQGGEAAHHTRSPYS	NEUROD6	191	Q96NK8