Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domainfn3

SDK2 PTPRC RIMBP2 SDK1

1.71e-03162594PF00041
DomainFN3

SDK2 PTPRC RIMBP2 SDK1

2.77e-03185594SM00060
DomainFN3

SDK2 PTPRC RIMBP2 SDK1

3.60e-03199594PS50853
DomainFN3_dom

SDK2 PTPRC RIMBP2 SDK1

4.29e-03209594IPR003961
DomainSNF2_N

ERCC6 CHD8

4.58e-0332592IPR000330
DomainPID

CCM2 SHC3

4.58e-0332592PS01179
DomainSNF2_N

ERCC6 CHD8

4.58e-0332592PF00176
DomainPTB/PI_dom

CCM2 SHC3

7.43e-0341592IPR006020
Pubmed

Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.

SDK2 SDK1

2.93e-06260215213259
Pubmed

Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.

SDK2 SDK1

2.93e-06260215703275
Pubmed

Architecture of cell-cell adhesion mediated by sidekicks.

SDK2 SDK1

2.93e-06260230150416
Pubmed

Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.

SDK2 SDK1

2.93e-06260212230981
Pubmed

Molecular basis of sidekick-mediated cell-cell adhesion and specificity.

SDK2 SDK1

2.93e-06260227644106
Pubmed

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.

VHL DVL2

8.77e-06360236357669
Pubmed

CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.

NPR1 CCM2

8.77e-06360228432261
Pubmed

A mouse carrying genetic defect in the choice between T and B lymphocytes.

VPREB1 PTPRC

1.75e-0546029794386
Pubmed

The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges.

SDK2 SDK1

2.92e-05560234545809
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

ARHGAP32 WWC2 PCLO TNRC6A DVL2

3.81e-0521860533378226
Pubmed

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.

HGS SSX2IP RFX4

4.27e-053960322458338
Pubmed

Expression and Roles of the Immunoglobulin Superfamily Recognition Molecule Sidekick1 in Mouse Retina.

SDK2 SDK1

4.37e-05660230687002
Pubmed

Reporter-nanobody fusions (RANbodies) as versatile, small, sensitive immunohistochemical reagents.

SDK2 SDK1

4.37e-05660229440485
Pubmed

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.

VHL DVL2

4.37e-05660220639871
Pubmed

Functional proteomics mapping of a human signaling pathway.

VHL NPR1 ERCC6 PTPRC EXPH5 ARFGEF2 SDK1

6.99e-0559160715231748
Pubmed

Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the  receptor protein of CRL2Prame complex.

VHL KLHL9 FBXW9

7.99e-054860333504946
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

ARHGAP32 EXPH5 HGS TNRC6A DVL2

9.26e-0526360534702444
Pubmed

The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.

VHL DVL2

1.05e-04960225825496
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

MFAP1 NAA35 ERCC6 ATP7B FAT3 SSX2IP TNRC6A DVL2 CHD8

1.19e-04111660931753913
Pubmed

Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo.

VPREB1 PTPRC

1.31e-041060215909309
Pubmed

G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.

ARHGAP32 RFX4

1.59e-041160218218630
Pubmed

VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.

VHL PTPRC

1.59e-041160220382704
Pubmed

Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.

ARHGAP32 SHC3

1.91e-041260212446789
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

MFAP1 HGS SSX2IP TNRC6A

2.12e-0416960431462741
Pubmed

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.

PTPRC TG

2.26e-041360222724066
Pubmed

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.

PTPRC CHD8

2.26e-041360228402856
Pubmed

Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.

SSX2IP RIMBP2

2.63e-041460216112646
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

MFAP1 KLHL9 ATP7B TRAPPC12 HGS SNRNP35 TNRC6A

2.63e-0473360734672954
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ARHGAP32 WWC2 PTPRC HGS SSX2IP TNRC6A PPEF1 RBM20

4.25e-04104960827880917
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

SDK2 FAT3 SDK1

5.32e-049160328558017
Pubmed

Widespread macromolecular interaction perturbations in human genetic disorders.

VHL CCM2 HGS SSX2IP BEGAIN EPM2AIP1

5.35e-0459060625910212
Pubmed

A quantitative survey of gravity receptor function in mutant mouse strains.

ESPN USH1G

5.45e-042060216235133
Pubmed

Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development.

VHL PTPRC

5.45e-042060239040069
Pubmed

PTPN14 is required for the density-dependent control of YAP1.

VHL WWC2

6.02e-042160222948661
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

ARHGAP32 KLHL9 GPATCH1 HGS SSX2IP TNRC6A DVL2

6.50e-0485360728718761
Pubmed

Mechanical load regulates bone growth via periosteal Osteocrin.

NPR1 PTPRC

6.61e-042260234260913
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ARHGAP32 ZNF432 EPM2AIP1

7.21e-041016039872452
Pubmed

Sidekick 2 directs formation of a retinal circuit that detects differential motion.

SDK2 SDK1

7.23e-042360226287463
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SDK2 TNRC6A BEGAIN

7.64e-0410360310819331
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

NFIB UHRF1 CHD8

9.00e-0410960333554859
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

CHST12 TG

9.26e-042660233905568
Pubmed

A human MAP kinase interactome.

ARHGAP32 EXPH5 HGS TNRC6A CHD8

1.52e-0348660520936779
Pubmed

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

DVL2 CHD8

1.58e-033460230894540
CoexpressionNFE2L2.V2

UGT1A4 VPREB1 GLA SLCO4C1 FAT3 SPDYE3 DGKG RFX4

1.12e-05469608M2870
CoexpressionZHONG_PFC_C3_MICROGLIA

SDK2 NFIB FAT3 PCLO RIMBP2 SDK1 MOAP1 EPM2AIP1

1.49e-05488608M39104
DiseaseMacrocephaly

NFIB CHD8

2.21e-0411602C0221355
Diseasecorpus callosum mid-anterior volume measurement

CCM2 TG

1.38e-0327602EFO_0010297
DiseaseMalignant neoplasm of breast

ERCC6 PTPRC ATP7B TRAPPC12 PCDHB15 ZNF432 ARFGEF2 DGKG

1.43e-031074608C0006142

Protein segments in the cluster

PeptideGeneStartEntry
EWGRAPLRDMFLSDE

USH1G

266

Q495M9
LVGEDAPRRAELEMW

CHD8

2326

Q9HCK8
GEDMRGQWRPLSVED

BEGAIN

411

Q9BUH8
EDAGELSRESMWDLS

SSX2IP

316

Q9Y2D8
MDDRWRDSPRATPWD

ATP7B

1406

P35670
LLTWRPVGMEEDSSE

ARFGEF2

1486

Q9Y6D5
IDDCWMAPQRDSEGR

GLA

91

P06280
DRSAPSEGDEWDRMI

CCM2

411

Q9BSQ5
QEEPWEEEFGREMRR

FAM186B

476

Q8IYM0
SGDRETDFSLWDMDP

NPR1

401

P16066
AAPESGLEVRDRMWL

DVL2

431

O14641
ARRPWESDMRPEAEG

ERCC6

351

Q03468
NGDDKRDRMDPWAHD

RBM20

696

Q5T481
PAAGSRTWHERDQDM

NFIB

296

O00712
LEEPDMDSTESWIER

RFX4

6

Q33E94
FSELWRAIMDIDPDG

ANKAR

171

Q7Z5J8
ARRPWESDMRPEAEG

ERCC6

351

P0DP91
MELPLGRCDDSRTWD

FBXW9

1

Q5XUX1
EGDAWRMEREDSSEE

MFAP1

121

P55081
EEESPRWGSLHEMEE

JHY

76

Q6NUN7
TRPLVEAEWEAGMTD

METTL25

76

Q8N6Q8
EEEEEARLASMPAWR

ESPN

776

B1AK53
LERCLDPSMTEWERG

GPATCH1

531

Q9BRR8
DPSMTEWERGRERDE

GPATCH1

536

Q9BRR8
RESPEPGEEEFGRWM

MOAP1

171

Q96BY2
DEDQDEWDMPTRSRR

PCLO

3476

Q9Y6V0
DERAQEWRSLAPMDA

KLHL9

321

Q9P2J3
GMDASELTPRAWERI

EXPH5

1146

Q8NEV8
AGWEPRRYSVMEETE

PCDHB15

26

Q9Y5E8
PDWEETLSAMARGAD

ARHGAP32

66

A7KAX9
EEEAPWAATERRMPG

MCAT

46

Q8IVS2
MGEERWVSLTPEEFD

DGKG

1

P49619
VATTEMEPGWDDLVR

EPM2AIP1

586

Q7L775
MEPGWDDLVRERNES

EPM2AIP1

591

Q7L775
RDTLEDMAWRLADGV

FRRS1

286

Q6ZNA5
TSDWMPGARLSDIEE

FAT3

4356

Q8TDW7
RLRPEEMFETWEDDL

CASQ2

251

O14958
VIEARPSDEGLWDMF

SDK1

1936

Q7Z5N4
MLVRWSEVPEADRNG

SDK2

1216

Q58EX2
MRDRWDYVDSIDVPD

PPEF1

91

O14829
MPWDIVIRTRAEDEG

SMG8

796

Q8ND04
GPHARMDEAWEQSRA

RIMBP2

616

O15034
RMQSLDEPWTEEEGD

SHC3

321

Q92529
RTVPGEEETRMWAQD

IL1R2

76

P27930
EDMLSALGWSREDRP

CIPC

61

Q9C0C6
SMEESVRGYDWSPRD

CHST12

96

Q9NRB3
TREWPMPEDLAEADD

CNGA4

536

Q8IV77
PDGDWLTMLREASDE

WWC2

891

Q6AWC2
SVDDDDSGWELSMPE

NAA35

6

Q5VZE5
SEMDRRNDAWLPGEA

TRAPPC12

301

Q8WVT3
AMGESTDVTEDDPRW

SLCO4C1

296

Q6ZQN7
SMRCRAWVSPEELEE

SPDYE3

516

A6NKU9
EREREWEEEMEPTAA

VPREB1

126

P12018
MFAAERAPDWVDAEE

HGS

151

O14964
MPRRAENWDEAEVGA

VHL

1

P40337
GTDEDPHDRAVWRAM

SNRNP35

21

Q16560
ETDSRPADEDMWDET

UHRF1

116

Q96T88
ERGEEPWTMEDERHS

ZNF432

61

O94892
QGPRDETVDDFWRMI

PTPRC

726

P08575
MDREESEGWPAIDGS

TG

2306

P01266
RRKMEIDDGTSAWGD

TNRC6A

996

Q8NDV7
MRESRWEADTLDKEG

ULK3

446

Q6PHR2
TDGSPWLSMREALRE

UGT1A4

36

P22310