Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	response to ATP	P2RX3 P2RX4 IL1B TOP2B RYR1	8.25e-07	40	90	5	GO:0033198
GeneOntologyBiologicalProcess	cellular response to ATP	P2RX3 P2RX4 TOP2B RYR1	1.92e-06	21	90	4	GO:0071318
GeneOntologyBiologicalProcess	retrograde transport, vesicle recycling within Golgi	COG6 COG5 COG8	9.43e-06	10	90	3	GO:0000301
GeneOntologyCellularComponent	Golgi transport complex	COG6 COG5 COG8	9.37e-06	10	91	3	GO:0017119
GeneOntologyCellularComponent	axon cytoplasm	AP3S1 DST MAPK8IP3 AP3S2	2.21e-04	68	91	4	GO:1904115
GeneOntologyCellularComponent	centriolar satellite	FAM184A TBC1D31 GPR174 LRRC49 PTPN20	2.43e-04	128	91	5	GO:0034451
Domain	HECT	UBE3C HUWE1 TRIP12	2.63e-04	27	87	3	PF00632
Domain	HECTc	UBE3C HUWE1 TRIP12	2.63e-04	27	87	3	SM00119
Domain	HECT_dom	UBE3C HUWE1 TRIP12	2.63e-04	27	87	3	IPR000569
Domain	HECT	UBE3C HUWE1 TRIP12	2.63e-04	27	87	3	PS50237
Domain	P2X_receptor	P2RX3 P2RX4	4.44e-04	7	87	2	PF00864
Domain	P2X_purnocptor	P2RX3 P2RX4	4.44e-04	7	87	2	IPR001429
Domain	-	P2RX3 P2RX4	4.44e-04	7	87	2	2.60.490.10
Domain	P2X_RECEPTOR	P2RX3 P2RX4	4.44e-04	7	87	2	PS01212
Domain	P2X_extracellular_dom	P2RX3 P2RX4	4.44e-04	7	87	2	IPR027309
Domain	AP_complex_ssu	AP3S1 AP3S2	4.44e-04	7	87	2	IPR016635
Domain	MCM_OB	MCM9 MCM3	5.90e-04	8	87	2	IPR033762
Domain	MCM_2	MCM9 MCM3	5.90e-04	8	87	2	PS50051
Domain	MCM_1	MCM9 MCM3	5.90e-04	8	87	2	PS00847
Domain	MCM_OB	MCM9 MCM3	5.90e-04	8	87	2	PF17207
Domain	MCM	MCM9 MCM3	7.56e-04	9	87	2	SM00350
Domain	MCM_dom	MCM9 MCM3	7.56e-04	9	87	2	IPR001208
Domain	CLAT_ADAPTOR_S	AP3S1 AP3S2	7.56e-04	9	87	2	PS00989
Domain	MCM	MCM9 MCM3	7.56e-04	9	87	2	IPR031327
Domain	MCM	MCM9 MCM3	7.56e-04	9	87	2	PF00493
Domain	WWE	HUWE1 TRIP12	1.37e-03	12	87	2	PS50918
Domain	WWE	HUWE1 TRIP12	1.37e-03	12	87	2	PF02825
Domain	Clathrin_sm-chain_CS	AP3S1 AP3S2	1.37e-03	12	87	2	IPR000804
Domain	WWE-dom	HUWE1 TRIP12	1.37e-03	12	87	2	IPR004170
Domain	AP_mu_sigma_su	AP3S1 AP3S2	2.47e-03	16	87	2	IPR022775
Domain	Clat_adaptor_s	AP3S1 AP3S2	2.47e-03	16	87	2	PF01217
Domain	WD40_repeat_dom	FBXW10 TBC1D31 SMU1 GNB4 CFAP43 MAPK8IP3	2.64e-03	297	87	6	IPR017986
Domain	RhoGAP	ARHGAP24 ARHGAP44 ARHGAP27	3.03e-03	62	87	3	SM00324
Domain	RhoGAP	ARHGAP24 ARHGAP44 ARHGAP27	3.17e-03	63	87	3	PF00620
Domain	RHOGAP	ARHGAP24 ARHGAP44 ARHGAP27	3.31e-03	64	87	3	PS50238
Domain	RhoGAP_dom	ARHGAP24 ARHGAP44 ARHGAP27	3.31e-03	64	87	3	IPR000198
Domain	-	ARHGAP24 ARHGAP44 ARHGAP27	3.31e-03	64	87	3	1.10.555.10
Domain	-	FBXW10 TBC1D31 SMU1 GNB4 CFAP43 MAPK8IP3	4.62e-03	333	87	6	2.130.10.10
Pubmed	Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication.	COG6 COG5 COG8	6.92e-08	4	91	3	25179963
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	THADA MDN1 DST ZNF335 POLR2A ARHGAP44 NOB1 MFN2 LRP5 CFAP43 UBE3C HUWE1 RYR1 ANO8 MAPK8IP3	1.77e-07	1105	91	15	35748872
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	AP3S1 MDN1 DST DSC3 POLR2A NOB1 SMU1 ALDH18A1 MCM3 RECQL POLR1B DGKD HUWE1 TRIP12 GFPT1 TOP2B	4.19e-07	1353	91	16	29467282
Pubmed	A protein interaction landscape of breast cancer.	MDN1 DST POLR2A MCM9 DHPS COPS4 SMU1 ALDH18A1 UBE3C TOP2B CHP1	8.57e-07	634	91	11	34591612
Pubmed	Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.	COG6 COG5 COG8	9.61e-07	8	91	3	11929878
Pubmed	The binary interacting network of the conserved oligomeric Golgi tethering complex.	COG6 COG5 COG8	9.61e-07	8	91	3	15047703
Pubmed	Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.	COG6 COG5 COG8	9.61e-07	8	91	3	11980916
Pubmed	COG Complex Complexities: Detailed Characterization of a Complete Set of HEK293T Cells Lacking Individual COG Subunits.	COG6 COG5 COG8	9.61e-07	8	91	3	27066481
Pubmed	Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.	UBE3C HUWE1 TRIP12	1.44e-06	9	91	3	9575161
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SCYL2 THADA MDN1 DST LRRC49 FASTKD1 MFN2 CDK5RAP2 TMEM131 GNB4 DHX35 CRYBG3 UBE3C HUWE1 ME2 CHP1	1.57e-06	1496	91	16	32877691
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TBC1D31 ZFYVE9 DSC3 POLR2A DHPS ALDH18A1 CDK5RAP2 GNB4 SSH2 CRYBG3 HUWE1 PTPN20 NIN	3.46e-06	1049	91	13	27880917
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	THBS4 AP3S1 MDN1 DST POLR2A ALDH18A1 CHD6 HUWE1 TRIP12 GFPT1 RYR1	3.61e-06	736	91	11	29676528
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	THADA AP3S1 MDN1 DST COG6 NOB1 SMU1 ALDH18A1 MCM3 RECQL UBE3C HUWE1 COG5 TOP2B CHP1	4.77e-06	1440	91	15	30833792
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	RMI1 DST ZFYVE9 COPS4 RECQL UBE3C HUWE1 TRIP12 CHP1	4.94e-06	481	91	9	28190767
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MDN1 DST ZNF335 IFFO2 CDK5RAP2 CHD6 GFPT1 NIN	5.22e-06	363	91	8	14691545
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	THADA AP3S1 DST IFFO2 ALDH18A1 CDK5RAP2 MCM3 HUWE1 TRIP12 PKHD1L1 AP3S2	6.02e-06	777	91	11	35844135
Pubmed	Molecular characterization and pharmacological properties of the human P2X3 purinoceptor.	P2RX3 P2RX4	6.77e-06	2	91	2	9221902
Pubmed	Mouse germ cell-less as an essential component for nuclear integrity.	GMCL1 GMCL2	6.77e-06	2	91	2	12556490
Pubmed	Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.	P2RX3 P2RX4	6.77e-06	2	91	2	9016352
Pubmed	Synergistic effects of electronegative-LDL- and palmitic-acid-triggered IL-1β production in macrophages via LOX-1- and voltage-gated-potassium-channel-dependent pathways.	IL1B OLR1	6.77e-06	2	91	2	34052311
Pubmed	Interleukin-1β Promotes Ox-LDL Uptake by Human Glomerular Mesangial Cells via LOX-1.	IL1B OLR1	6.77e-06	2	91	2	32410835
Pubmed	Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation.	COG5 COG8	6.77e-06	2	91	2	18353293
Pubmed	Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells.	GMCL1 GMCL2	6.77e-06	2	91	2	10448096
Pubmed	A new inborn error of glycosylation due to a Cog8 deficiency reveals a critical role for the Cog1-Cog8 interaction in COG complex formation.	COG6 COG8	6.77e-06	2	91	2	17220172
Pubmed	Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility.	GMCL1 GMCL2	6.77e-06	2	91	2	15700541
Pubmed	COG8 deficiency causes new congenital disorder of glycosylation type IIh.	COG6 COG8	6.77e-06	2	91	2	17331980
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MDN1 DST POLR2A SMU1 ALDH18A1 RECQL HUWE1 TRIP12 ME2 GFPT1	8.34e-06	653	91	10	22586326
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	DST NFYC SMU1 ALDH18A1 MCM3 RECQL POLR1B SSH2 TRIP12 TOP2B	9.15e-06	660	91	10	32780723
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	SCYL2 AP3S1 DST ZFYVE9 DSC3 CHP1 AP3S2	1.04e-05	285	91	7	34369648
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	AP3S1 POLR2A SMU1 MCM3 RECQL POLR1B HUWE1 TRIP12 GFPT1 TOP2B	1.59e-05	704	91	10	29955894
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SCYL2 FBXW10 AP3S1 POLR2A NOB1 SMU1 GNB4 DHX35 SSH2 VPS37B CHP1 AP3S2	1.69e-05	1038	91	12	26673895
Pubmed	AP-3: an adaptor-like protein complex with ubiquitous expression.	AP3S1 AP3S2	2.03e-05	3	91	2	9118953
Pubmed	The mouse Mcmd gene for DNA replication protein P1MCM3 maps to bands A3-A5 on chromosome 1 by fluorescence in situ hybridization.	DST MCM3	2.03e-05	3	91	2	8838817
Pubmed	Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.	GMCL1 GMCL2	2.03e-05	3	91	2	9878064
Pubmed	Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.	COG6 COG5	2.03e-05	3	91	2	16051600
Pubmed	Subunit architecture of the conserved oligomeric Golgi complex.	COG6 COG5	2.03e-05	3	91	2	16020545
Pubmed	Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.	MFN2 HUWE1	2.03e-05	3	91	2	22748923
Pubmed	The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.	COG6 COG8	2.03e-05	3	91	2	11703943
Pubmed	Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies.	P2RX3 P2RX4	2.03e-05	3	91	2	15081800
Pubmed	A genome-wide association study identifies protein quantitative trait loci (pQTLs).	COL11A1 DSC3 POLR2A PAFAH1B2	2.04e-05	61	91	4	18464913
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	POLR2A DHPS COPS4 SMU1 RECQL TRIP12	2.07e-05	212	91	6	33462405
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POLR2A MCM3 POLR1B DHX35 HUWE1 TRIP12 GFPT1 TOP2B	2.09e-05	440	91	8	34244565
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SCYL2 GMCL1 DST COPS4 TMEM131 DHX35 CHD6 HUWE1 TRIP12 OLR1 GFPT1 KRIT1 MAPK8IP3	2.97e-05	1285	91	13	35914814
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	FAM184A THADA TBC1D31 MDN1 DSC3 DHPS COPS4 SMU1 CDK5RAP2 TMEM131 CRYBG3 ME2 TOP2B NIN	3.14e-05	1487	91	14	33957083
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MDN1 DST FAM186A ZNF335 TRIP12 TOP2B	3.60e-05	234	91	6	36243803
Pubmed	HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.	HUWE1 TRIP12	4.05e-05	4	91	2	23209776
Pubmed	Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors.	P2RX3 P2RX4	4.05e-05	4	91	2	20699225
Pubmed	Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.	MFN2 IL1B	4.05e-05	4	91	2	24127597
Pubmed	BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ.	POLR2A TOP2B	4.05e-05	4	91	2	34610268
Pubmed	Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.	GMCL1 GMCL2	4.05e-05	4	91	2	12927808
Pubmed	Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+.	P2RX3 P2RX4	4.05e-05	4	91	2	23959888
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	TBC1D31 DST POLR2A RECQL GNB4 CHD6 HUWE1 TRIP12 NIN	4.98e-05	645	91	9	25281560
Pubmed	Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.	MFN2 TEAD3	6.74e-05	5	91	2	12527753
Pubmed	Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.	AP3S1 AP3S2	6.74e-05	5	91	2	12967569
Pubmed	Activity-Based Probes for HECT E3 Ubiquitin Ligases.	UBE3C HUWE1	6.74e-05	5	91	2	28425671
Pubmed	The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.	MCM9 MCM3	6.74e-05	5	91	2	27757957
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	COG6 TMEM131 HUWE1 MAPK8IP3	8.27e-05	87	91	4	12465718
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	THADA MDN1 POLR2A COPS4 SMU1 ALDH18A1 MCM3 RECQL UBE3C HUWE1 ME2 GFPT1 TOP2B	8.52e-05	1425	91	13	30948266
Pubmed	Molecular physiology of P2X receptors.	P2RX3 P2RX4	1.01e-04	6	91	2	12270951
Pubmed	Ghrelin effects on mitochondrial fitness modulates macrophage function.	MFN2 IL1B	1.01e-04	6	91	2	31525456
Pubmed	Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.	AP3S1 AP3S2	1.01e-04	6	91	2	15537701
Pubmed	Identification of a mouse germ cell-less homologue with conserved activity in Drosophila.	GMCL1 GMCL2	1.01e-04	6	91	2	10727854
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	MDN1 POLR2A NOB1 MFN2 ALDH18A1 MCM3 POLR1B GNB4 UBE3C HUWE1 GFPT1 CHP1	1.07e-04	1257	91	12	37317656
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	POLR2A COPS4 HUWE1	1.16e-04	36	91	3	35379950
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TBC1D31 P2RX4 INTS13 NOB1 NFYC CDK5RAP2 TMEM131 HUWE1 COG5 TRIP12 ME2	1.25e-04	1084	91	11	11544199
Pubmed	Update of P2X receptor properties and their pharmacology: IUPHAR Review 30.	P2RX3 P2RX4	1.41e-04	7	91	2	33125712
Pubmed	Membrane compartments and purinergic signalling: occurrence and function of P2X receptors in lung.	P2RX3 P2RX4	1.41e-04	7	91	2	19076210
Pubmed	ATP-gated P2X cation-channels.	P2RX3 P2RX4	1.41e-04	7	91	2	18657557
Pubmed	Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels.	P2RX3 P2RX4	1.41e-04	7	91	2	17895406
Pubmed	TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.	HUWE1 TRIP12	1.41e-04	7	91	2	22561347
Pubmed	A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.	POLR2A HUWE1	1.41e-04	7	91	2	31980388
Pubmed	Characterization of the adaptor-related protein complex, AP-3.	AP3S1 AP3S2	1.41e-04	7	91	2	9151686
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CDK5RAP2 HUWE1 ANO8 NIN	1.47e-04	101	91	4	10997877
Pubmed	An ear-core interaction regulates the recruitment of the AP-3 complex to membranes.	AP3S1 AP3S2	1.88e-04	8	91	2	15469849
Pubmed	Association of the AP-3 adaptor complex with clathrin.	AP3S1 AP3S2	1.88e-04	8	91	2	9545220
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	PAFAH1B2 NOB1 ALDH18A1 MCM3 RECQL HUWE1 ME2 GFPT1	1.96e-04	607	91	8	39147351
Pubmed	SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.	DST POLR2A ME2 GFPT1	2.05e-04	110	91	4	28883622
Pubmed	Congenital Disorders of N-Linked Glycosylation and Multiple Pathway Overview	COG6 COG5 COG8	2.12e-04	44	91	3	20301507
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	NFYC LRP5 CDK5RAP2	2.12e-04	44	91	3	20200978
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ARHGAP24 MDN1 DST ARHGAP44 MFN2 CDK5RAP2 MCM3 SSH2 HUWE1 MAPK8IP3	2.14e-04	963	91	10	28671696
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RMI1 POLR2A PAFAH1B2 COPS4 IFFO2 ALDH18A1 CDK5RAP2 GNB4 DHX35 COG5 TOP2B	2.16e-04	1155	91	11	20360068
Pubmed	Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.	MFN2 HUWE1	2.41e-04	9	91	2	28943312
Pubmed	Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.	CD207 IL1B	2.41e-04	9	91	2	25240383
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	SCYL2 MDN1 POLR2A SMU1 MCM3 UBE3C HUWE1 TOP2B	2.74e-04	638	91	8	33239621
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MDN1 INTS13 NOB1 YY2 CDK5RAP2 CHD6 GFPT1 RYR1	2.74e-04	638	91	8	31182584
Pubmed	A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.	CDK5RAP2 NIN	3.01e-04	10	91	2	25220058
Pubmed	NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.	POLR2A NFYC	3.01e-04	10	91	2	15601870
Pubmed	HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.	MFN2 HUWE1	3.01e-04	10	91	2	30217973
Pubmed	Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation.	CD207 IL1B	3.01e-04	10	91	2	37576598
Pubmed	Mechanism of glycyrrhizic acid inhibition of Kaposi's sarcoma-associated herpesvirus: disruption of CTCF-cohesin-mediated RNA polymerase II pausing and sister chromatid cohesion.	POLR2A MCM3	3.01e-04	10	91	2	21880767
Pubmed	HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.	AP3S1 AP3S2	3.01e-04	10	91	2	18076669
Pubmed	Genomic analysis of mouse retinal development.	DST COG6 POLR2A LRRC49 CARF MCM9 FASTKD1 SMU1 ARHGAP27 VPS37B	3.03e-04	1006	91	10	15226823
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	FAM184A TBC1D31 NOB1 IFFO2 MCM3 TMEM131 UBE3C GFPT1 NIN	4.01e-04	853	91	9	28718761
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	MDN1 POLR2A MFN2 MCM3 RECQL	4.07e-04	237	91	5	29564676
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	AP3S1 INTS13 POLR2A PAFAH1B2 DHPS COPS4 MCM3 RECQL UBE3C HUWE1 COG5 GFPT1	4.09e-04	1455	91	12	22863883
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	POLR2A DHPS SMU1 ALDH18A1 MCM3 RECQL DHX35 HUWE1 TEAD3 TRIP12 GFPT1	4.14e-04	1247	91	11	27684187
Pubmed	Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less).	GMCL1 GMCL2	4.39e-04	12	91	2	11591818
Pubmed	Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production.	NFYC IL1B	4.39e-04	12	91	2	19734906
Pubmed	A functional interaction between the survival motor neuron complex and RNA polymerase II.	POLR2A COG8	5.18e-04	13	91	2	11149922
Pubmed	NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.	MCM3 CHD6	5.18e-04	13	91	2	28416489
Interaction	OCIAD1 interactions	SCYL2 THADA COG6 INSC LRRC49 MFN2 GNB4 CRYBG3 HUWE1 COG5 COG8	2.62e-06	419	90	11	int:OCIAD1
Interaction	PARP16 interactions	GMCL1 MDN1 COG6 LRP5 COG5	2.87e-06	50	90	5	int:PARP16
Interaction	VSIG2 interactions	THADA COG6 COG5 COG8	1.22e-05	32	90	4	int:VSIG2
Interaction	VSIG1 interactions	AP3S1 MDN1 COG6 MFN2 COG5	1.75e-05	72	90	5	int:VSIG1
Interaction	TACSTD2 interactions	THADA AP3S1 MDN1 FASTKD1 UBE3C COG5	2.45e-05	129	90	6	int:TACSTD2
Interaction	SCN2B interactions	THADA MDN1 COG6 FASTKD1 UBE3C	6.70e-05	95	90	5	int:SCN2B
Interaction	DTNBP1 interactions	AP3S1 DST COG6 CDK5RAP2 COG5 AP3S2	8.77e-05	162	90	6	int:DTNBP1
Interaction	MCM7 interactions	ARHGAP24 COG6 POLR2A SMU1 MCM3 RECQL POLR1B HUWE1 TOP2B	9.71e-05	414	90	9	int:MCM7
Interaction	ARRDC2 interactions	POLR2A SMU1 UBE3C HUWE1	9.92e-05	54	90	4	int:ARRDC2
Interaction	NRIP1 interactions	DST POLR2A TMEM131 HUWE1 TRIP12 MAPK8IP3	1.14e-04	170	90	6	int:NRIP1
Interaction	GAGE12B interactions	GMCL1 GMCL2	1.18e-04	4	90	2	int:GAGE12B
Interaction	GAGE12I interactions	GMCL1 GMCL2	1.18e-04	4	90	2	int:GAGE12I
Interaction	COG4 interactions	COG6 MFSD4A COG5 COG8 CHP1	1.23e-04	108	90	5	int:COG4
GeneFamily	Components of oligomeric golgi complex	COG6 COG5 COG8	2.02e-06	8	61	3	493
GeneFamily	Purinergic receptors P2X	P2RX3 P2RX4	2.33e-04	7	61	2	214
GeneFamily	MCM family	MCM9 MCM3	3.97e-04	9	61	2	1085
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP24 ARHGAP44 ARHGAP27	6.40e-04	50	61	3	721
GeneFamily	WD repeat domain containing	FBXW10 TBC1D31 SMU1 GNB4 CFAP43	1.89e-03	262	61	5	362
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	CD207 OLR1	3.72e-03	27	61	2	1253
GeneFamily	RNA polymerase subunits	POLR2A POLR1B	4.29e-03	29	61	2	726
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	THADA ARMC3	9.25e-03	43	61	2	409
GeneFamily	C-type lectin domain family	CD207 OLR1	1.10e-02	47	61	2	494
Coexpression	GSE21670_UNTREATED_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN	FAM184A MDN1 DHPS ALDH18A1 POLR1B UBE3C IL1B	5.78e-06	197	91	7	M7458
Disease	phospholipase B-like 1 measurement	COPS4 MFN2	9.15e-05	5	90	2	EFO_0802865
Disease	Abnormal muscle tone	DHPS MAPK8IP3	1.37e-04	6	90	2	C0852413
Disease	Congenital disorder of glycosylation	COG6 COG5 COG8	2.14e-04	38	90	3	cv:C0282577
Disease	multiple system atrophy	RMI1 ARHGAP44 PKHD1L1	2.50e-04	40	90	3	EFO_1001050
Disease	Behcet's syndrome	THADA CNTN5 IL1B	5.76e-04	53	90	3	EFO_0003780
Disease	Global developmental delay	ZNF335 POLR2A DHPS MAPK8IP3	7.47e-04	133	90	4	C0557874
Disease	trimethylamine-N-oxide measurement	INTS13 UBE3C	8.17e-04	14	90	2	EFO_0010541
Disease	Autosomal recessive primary microcephaly	ZNF335 CDK5RAP2	9.41e-04	15	90	2	cv:C3711387
Disease	hemoglobin A1 measurement	GMCL2 THADA CNTN5 DGKD UBE3C COG5 AP3S2	1.07e-03	520	90	7	EFO_0007629
Disease	Van Buchem disease	COL11A1 LRP5	1.21e-03	17	90	2	C0432272
Disease	cortical thickness	THADA COL11A1 FBXW10 LRRC49 CDK5RAP2 TMEM131 SSH2 ME2 PTPN20 MAPK8IP3	2.09e-03	1113	90	10	EFO_0004840
Disease	Mechanical Allodynia	P2RX3 MFN2 IL1B	2.19e-03	84	90	3	C2936719
Disease	Allodynia	P2RX3 MFN2 IL1B	2.19e-03	84	90	3	C0458247
Disease	Hyperalgesia, Secondary	P2RX3 MFN2 IL1B	2.19e-03	84	90	3	C0751212
Disease	Hyperalgesia, Primary	P2RX3 MFN2 IL1B	2.19e-03	84	90	3	C0751211
Disease	Hyperalgesia, Thermal	P2RX3 MFN2 IL1B	2.19e-03	84	90	3	C0751214
Disease	Tactile Allodynia	P2RX3 MFN2 IL1B	2.19e-03	84	90	3	C0751213
Disease	Hyperalgesia	P2RX3 MFN2 IL1B	2.19e-03	84	90	3	C0020429
Disease	response to xenobiotic stimulus	STX2 THADA ENOX1 IFFO2	2.37e-03	182	90	4	GO_0009410

Protein segments in the cluster

Peptide	Gene	Start	Entry
IQSMRISMDGQNILV	CFAP43	686	Q8NDM7
IQQTEGLEEQGMENM	CRYBG3	1256	Q68DQ2
ILQNSMVTVMTNINS	CDKL4	346	Q5MAI5
QGNRMVVNTESNVLM	FBXW10	666	Q5XX13
SMNNTTEDILGMVQI	ADGRF4	261	Q8IZF3
GGMVLETNMNEIVAQ	AP3S2	126	P59780
LEDMDTMVQIQQTGG	ARMC3	261	Q5W041
GGMVLETNMNEIVTQ	AP3S1	126	Q92572
IGMLQATQMTQEVTI	FAM184A	386	Q8NB25
QKVMEAMGVLAIVVN	ANO8	806	Q9HCE9
SVGVEMNTQNELMER	CDK5RAP2	1321	Q96SN8
VEMVNGVLMIHNVNQ	CNTN5	436	O94779
IGSSNLFVMQVEMDI	GMCL1	261	Q96IK5
EEVGNQNIVETSMMQ	RAD21L1	386	Q9H4I0
VMTNVILTMNQTQGL	P2RX4	101	Q99571
MIISQTTIFNMQAVV	INTS13	461	Q9NVM9
HLQGQDMEQQVVFSM	IL1B	146	P01584
TTIAQNVIMNITMVA	SLC17A3	51	O00476
TGVENMQNTQAMELA	MDN1	5036	Q9NU22
TTDFAMQNVLLQMGL	NOB1	236	Q9ULX3
NMEVQVTQEMRNVSI	MAPK8IP3	316	Q9UPT6
GEMVLQMLVGSIFQA	MFSD4A	446	Q8N468
IDMVQRSTLQENTGM	DST	1721	Q03001
GMETETINQQLNMFK	DST	5311	Q03001
NMIESSNMLGQERVV	LRP5	826	O75197
ELQSLGESNAQMMIV	CARF	91	Q8N187
VEGNSINMVQMTFLK	COL11A1	1686	P12107
QMITEGRMNGFIDQI	COPS4	341	Q9BT78
GIVNEVRQSMQLMLS	COG8	196	Q96MW5
KINGTEVTQNDMIMA	LRRC49	526	Q8IUZ0
NTTVQQIMEGMRLSQ	KRIT1	441	O00522
QIMEGMRLSQETQQY	KRIT1	446	O00522
VQITSNMDSVGRIQM	GNB4	31	Q9HAV0
NVNLAQSVVMMTIGE	GPR174	176	Q9BXC1
VTIMVLGMQLSQVSD	OLR1	51	P78380
VMTQEVGQLLQDMGD	HUWE1	1971	Q7Z6Z7
RQIEQGMDMVISSVI	MEDAG	146	Q5VYS4
QTMQVMQQIITNTGE	NFYC	221	Q13952
ITNSLQTMQQDMIDG	MFN2	486	O95140
QVSVLQNQGREMMLV	ALDH18A1	101	P54886
QMVLENNSNVIAMIT	PTPN20	241	Q4JDL3
KMQDDNQVMVSEGII	MCM3	791	P25205
TIMEGTVVVQQLMSV	ARHGAP24	306	Q8N264
ATGIESLEGVLQMMQ	COG5	121	Q9UP83
RTNQQTAGLEIMEQM	COG6	201	Q9Y2V7
QETIEMMKGGNQTLE	DSC3	776	Q14574
GSQISRQMIQQYEMV	CHD6	541	Q8TD26
QEILSIAAMMQIQNI	DHX35	506	Q9H5Z1
ILDQMVMEQNTEGVK	DHPS	186	P49366
MDGTQQQIFKMLAEV	FASTKD1	696	Q53R41
GIVDSQLRNMFISMV	ANKRD7	221	Q92527
MNLQTMVDTLQEAAQ	IFFO2	231	Q5TF58
NLIVMSMVENGLSEQ	ME2	321	P23368
ILEVVAVFGSMQMAV	DGKD	871	Q16760
IQENGVQLIMGMLSE	INSC	456	Q1MX18
EIQGMLQELIGTTMF	FAM186A	236	A6NE01
VVMVFGFVMAITNTQ	SLC38A11	351	Q08AI6
EGNVVNGMIARQMVD	RYR1	4031	P21817
TMQGMQQQLLTIQEE	ENOX1	476	Q8TC92
MQNGTIITNMEDIGL	OTOGL	1696	Q3ZCN5
DVLFVGDSMVQLMQQ	PAFAH1B2	41	P68402
VIITKMIVTENQMQG	P2RX3	91	P56373
VVNAMTLFETNMEIG	MCM9	41	Q9NXL9
SMMLVQKVQDFQGNL	THADA	201	Q6YHU6
VLSQDGIMRFINMQT	TBC1D31	281	Q96DN5
GEQALMMTIVNLAQN	TOP2B	781	Q02880
GRAVQTLQMELQQIM	GFPT1	321	Q06210
QGNQEQLVTVMEERM	NIN	2026	Q8N4C6
MLQLTDGIVQIQGME	RMI1	136	Q9H9A7
IGSSNLFVMQVEMDV	GMCL2	261	Q8NEA9
MTMVFQNQVVELILQ	ARHGAP27	866	Q6ZUM4
GNQMNVSEEMKVTNI	SCYL2	626	Q6P3W7
EGNITEMMTTVSLQI	ARHGAP44	416	Q17R89
GEMINNIERNVMNAT	STX2	226	P32856
MQTLQNVSMVQSEIS	CCDC110	71	Q8TBZ0
GMEAAGVQIQMVNES	CD207	101	Q9UJ71
MMVGVNISDEQLGSI	CHP1	141	Q99653
ISSMVVMENVGQQKL	RECQL	426	P46063
VVLNQGMEIVQTMNS	THBS4	751	P35443
TVVIMNMQGQIVRSF	SMU1	421	Q2TAY7
NEMIVILGQMDSPTQ	SSH2	296	Q76I76
NMLTDMTLQGIEQIS	POLR2A	1291	P24928
MMNSVLENFTILQVV	TEAD3	386	Q99594
VRNNLTVMDAVMVQG	TMEM131	956	Q92545
QEMLMLQTQEEVVGY	YY2	76	O15391
ISVMINNIQCNVTMA	PKHD1L1	1946	Q86WI1
EELIGTMEQIFMNVA	POLR1B	631	Q9H9Y6
QAVIEMCQLLVMGNE	TRIP12	456	Q14669
GQLTEMVQKMEETQN	VPS37B	26	Q9H9H4
QSLEAMMEVVVVQQF	ZNF335	231	Q9H4Z2
IVEDGVMVQITAENM	ZFYVE9	1221	O95405
VTTSSEMQQCIQMEQ	UBE3C	581	Q15386
GARMMELTNVQQAVQ	KCNF1	276	Q9H3M0