Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF3454	NOTCH1 NOTCH3	2.10e-05	3	50	2	PF11936
Domain	DUF3454_notch	NOTCH1 NOTCH3	2.10e-05	3	50	2	IPR024600
Domain	DUF3454	NOTCH1 NOTCH3	2.10e-05	3	50	2	SM01334
Domain	EGF	PCSK5 STAB2 SCUBE2 VWDE NOTCH1 NOTCH3	3.72e-05	235	50	6	SM00181
Domain	Notch	NOTCH1 NOTCH3	4.20e-05	4	50	2	IPR008297
Domain	NODP	NOTCH1 NOTCH3	4.20e-05	4	50	2	PF07684
Domain	Notch_NODP_dom	NOTCH1 NOTCH3	4.20e-05	4	50	2	IPR011656
Domain	Notch_NOD_dom	NOTCH1 NOTCH3	4.20e-05	4	50	2	IPR010660
Domain	NOD	NOTCH1 NOTCH3	4.20e-05	4	50	2	PF06816
Domain	NOD	NOTCH1 NOTCH3	4.20e-05	4	50	2	SM01338
Domain	NODP	NOTCH1 NOTCH3	4.20e-05	4	50	2	SM01339
Domain	EGF-like_dom	PCSK5 STAB2 SCUBE2 VWDE NOTCH1 NOTCH3	5.14e-05	249	50	6	IPR000742
Domain	Growth_fac_rcpt_	PCSK5 STAB2 SCUBE2 NOTCH1 NOTCH3	5.96e-05	156	50	5	IPR009030
Domain	LNR	NOTCH1 NOTCH3	6.99e-05	5	50	2	PS50258
Domain	Znf_RING_CS	TRAF4 RAD18 TRIM54 RNF40 TRIM3	7.35e-05	163	50	5	IPR017907
Domain	WxxW_domain	CILP MUC5AC	1.05e-04	6	50	2	IPR025155
Domain	Mucin2_WxxW	CILP MUC5AC	1.05e-04	6	50	2	PF13330
Domain	Notch_dom	NOTCH1 NOTCH3	1.46e-04	7	50	2	IPR000800
Domain	Notch	NOTCH1 NOTCH3	1.46e-04	7	50	2	PF00066
Domain	NL	NOTCH1 NOTCH3	1.46e-04	7	50	2	SM00004
Domain	RING	TRAF4 RAD18 DEF8 TRIM54 RNF40 TRIM3	1.57e-04	305	50	6	SM00184
Domain	Znf_RING	TRAF4 RAD18 DEF8 TRIM54 RNF40 TRIM3	2.25e-04	326	50	6	IPR001841
Domain	EGF_CA	STAB2 SCUBE2 NOTCH1 NOTCH3	3.16e-04	122	50	4	SM00179
Domain	zf-C3HC4	TRAF4 RAD18 TRIM54 RNF40 TRIM3	3.17e-04	223	50	5	PF00097
Domain	EGF-like_Ca-bd_dom	STAB2 SCUBE2 NOTCH1 NOTCH3	3.37e-04	124	50	4	IPR001881
Domain	EGF	STAB2 SCUBE2 NOTCH1 NOTCH3	3.58e-04	126	50	4	PF00008
Domain	EGF_3	STAB2 SCUBE2 VWDE NOTCH1 NOTCH3	4.04e-04	235	50	5	PS50026
Domain	EGF_3	STAB2 SCUBE2	4.56e-04	12	50	2	PF12947
Domain	EGF_dom	STAB2 SCUBE2	4.56e-04	12	50	2	IPR024731
Domain	EGF_extracell	STAB2 NOTCH1 NOTCH3	5.55e-04	60	50	3	IPR013111
Domain	EGF_2	STAB2 NOTCH1 NOTCH3	5.55e-04	60	50	3	PF07974
Domain	EGF_1	STAB2 SCUBE2 VWDE NOTCH1 NOTCH3	5.85e-04	255	50	5	PS00022
Domain	EGF-like_CS	STAB2 SCUBE2 VWDE NOTCH1 NOTCH3	6.50e-04	261	50	5	IPR013032
Domain	EGF_2	STAB2 SCUBE2 VWDE NOTCH1 NOTCH3	6.97e-04	265	50	5	PS01186
Domain	VWD	MUC5AC VWDE	8.23e-04	16	50	2	SM00216
Domain	VWF_type-D	MUC5AC VWDE	8.23e-04	16	50	2	IPR001846
Domain	VWFD	MUC5AC VWDE	8.23e-04	16	50	2	PS51233
Domain	VWD	MUC5AC VWDE	8.23e-04	16	50	2	PF00094
Domain	ZF_RING_1	TRAF4 RAD18 TRIM54 RNF40 TRIM3	1.06e-03	291	50	5	PS00518
Domain	Znf_C3HC4_RING-type	TRAF4 RAD18 TRIM54 TRIM3	1.15e-03	172	50	4	IPR018957
Domain	PLAC	ADAMTS12 PCSK5	1.17e-03	19	50	2	PS50900
Domain	PLAC	ADAMTS12 PCSK5	1.17e-03	19	50	2	IPR010909
Domain	ZF_RING_2	TRAF4 RAD18 TRIM54 RNF40 TRIM3	1.18e-03	298	50	5	PS50089
Domain	-	TRAF4 RAD18 KDM5C TRIM54 RNF40 TRIM3	1.21e-03	449	50	6	3.30.40.10
Domain	HAD-like_dom	EPHX2 ATP2C2 ATP10B	1.24e-03	79	50	3	IPR023214
Domain	Znf_RING/FYVE/PHD	TRAF4 RAD18 KDM5C TRIM54 RNF40 TRIM3	1.36e-03	459	50	6	IPR013083
Domain	EGF_CA	SCUBE2 NOTCH1 NOTCH3	1.58e-03	86	50	3	PF07645
Domain	Ephrin_rec_like	PCSK5 SCUBE2	2.03e-03	25	50	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	PCSK5 SCUBE2	2.03e-03	25	50	2	IPR011641
Domain	EGF_Ca-bd_CS	SCUBE2 NOTCH1 NOTCH3	2.23e-03	97	50	3	IPR018097
Domain	EGF_CA	SCUBE2 NOTCH1 NOTCH3	2.36e-03	99	50	3	PS01187
Domain	ASX_HYDROXYL	SCUBE2 NOTCH1 NOTCH3	2.43e-03	100	50	3	PS00010
Domain	hEGF	NOTCH1 NOTCH3	2.54e-03	28	50	2	PF12661
Domain	VWC	CHRDL1 MUC5AC	2.54e-03	28	50	2	PF00093
Domain	EGF-type_Asp/Asn_hydroxyl_site	SCUBE2 NOTCH1 NOTCH3	2.87e-03	106	50	3	IPR000152
Domain	Znf-RING_LisH	TRIM54 TRIM3	3.73e-03	34	50	2	IPR027370
Domain	zf-RING_UBOX	TRIM54 TRIM3	3.73e-03	34	50	2	PF13445
Domain	ATPase_P-typ_cyto_domN	ATP2C2 ATP10B	3.95e-03	35	50	2	IPR023299
Domain	VWFC_1	CHRDL1 MUC5AC	4.18e-03	36	50	2	PS01208
Domain	P_typ_ATPase	ATP2C2 ATP10B	4.18e-03	36	50	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP2C2 ATP10B	4.18e-03	36	50	2	IPR018303
Domain	ATPASE_E1_E2	ATP2C2 ATP10B	4.18e-03	36	50	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2C2 ATP10B	4.41e-03	37	50	2	IPR008250
Domain	E1-E2_ATPase	ATP2C2 ATP10B	4.41e-03	37	50	2	PF00122
Domain	VWC	CHRDL1 MUC5AC	4.64e-03	38	50	2	SM00214
Domain	VWFC_2	CHRDL1 MUC5AC	4.64e-03	38	50	2	PS50184
Domain	VWF_dom	CHRDL1 MUC5AC	5.65e-03	42	50	2	IPR001007
Domain	C1_1	PRKD2 DEF8	1.02e-02	57	50	2	PF00130
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS12 MUC5AC NOTCH1 NOTCH3	2.90e-05	68	37	4	M27303
Pathway	KEGG_DORSO_VENTRAL_AXIS_FORMATION	PIWIL1 NOTCH1 NOTCH3	3.24e-05	24	37	3	M11190
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS12 ALG6 MUC5AC NOTCH1 NOTCH3	3.36e-05	143	37	5	M27275
Pathway	REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3	NOTCH1 NOTCH3	6.67e-05	5	37	2	M27411
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH1 NOTCH3	6.67e-05	5	37	2	MM14733
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	NOTCH1 NOTCH3	9.99e-05	6	37	2	M27068
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	NOTCH1 NOTCH3	1.40e-04	7	37	2	MM14734
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	NOTCH1 NOTCH3	3.63e-04	11	37	2	M47865
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	NOTCH1 NOTCH3	4.35e-04	12	37	2	M47532
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381	NOTCH1 NOTCH3	4.35e-04	12	37	2	M47533
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS12 ALG6 MUC5AC NOTCH1 NOTCH3	4.62e-04	250	37	5	M27554
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	NOTCH1 NOTCH3	5.13e-04	13	37	2	M47423
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	NOTCH1 NOTCH3	5.13e-04	13	37	2	M47534
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH1 NOTCH3	9.99e-04	18	37	2	M614
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	NOTCH1 NOTCH3	1.64e-03	23	37	2	MM14954
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	ASB17 TRAF4 TRIM54 RNF40 TRIM3	1.68e-06	138	50	5	28786561
Pubmed	Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature.	NOTCH1 NOTCH3	2.03e-06	2	50	2	34878922
Pubmed	Notch3 signaling is associated with MUC5AC expression and favorable prognosis in patients with small intestinal adenocarcinomas.	MUC5AC NOTCH3	2.03e-06	2	50	2	24810798
Pubmed	PLCε knockdown inhibits prostate cancer cell proliferation via suppression of Notch signalling and nuclear translocation of the androgen receptor.	AR NOTCH1	2.03e-06	2	50	2	25796442
Pubmed	The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance.	NOTCH1 NOTCH3	2.03e-06	2	50	2	26634853
Pubmed	A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.	NOTCH1 NOTCH3	2.03e-06	2	50	2	21191019
Pubmed	Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk.	NOTCH1 NOTCH3	2.03e-06	2	50	2	17881497
Pubmed	Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Individuals with Asthma.	MUC5AC NOTCH3	2.03e-06	2	50	2	31922915
Pubmed	The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.	NOTCH1 NOTCH3	2.03e-06	2	50	2	29023469
Pubmed	Nuclear Notch3 expression is associated with tumor recurrence in patients with stage II and III colorectal cancer.	NOTCH1 NOTCH3	2.03e-06	2	50	2	24728738
Pubmed	Distinct roles for Notch1 and Notch3 in human adipose-derived stem/stromal cell adipogenesis.	NOTCH1 NOTCH3	2.03e-06	2	50	2	33021719
Pubmed	Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations.	NOTCH1 NOTCH3	2.03e-06	2	50	2	26563570
Pubmed	Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation.	NOTCH1 NOTCH3	2.03e-06	2	50	2	14595837
Pubmed	Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.	NOTCH1 NOTCH3	2.03e-06	2	50	2	21768299
Pubmed	Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway.	NOTCH1 NOTCH3	2.03e-06	2	50	2	25700162
Pubmed	Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis.	NOTCH1 NOTCH3	2.03e-06	2	50	2	18069660
Pubmed	Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.	NOTCH1 NOTCH3	2.03e-06	2	50	2	16507912
Pubmed	E3 ubiquitin ligase FBXW7 balances airway cell fates.	MUC5AC NOTCH1 NOTCH3	4.22e-06	22	50	3	34998785
Pubmed	Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro.	NOTCH1 NOTCH3	6.07e-06	3	50	2	15987768
Pubmed	Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.	NOTCH1 NOTCH3	6.07e-06	3	50	2	7615640
Pubmed	Notch receptor expression in human brain arteriovenous malformations.	NOTCH1 NOTCH3	6.07e-06	3	50	2	25846406
Pubmed	The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.	NOTCH1 NOTCH3	6.07e-06	3	50	2	7918097
Pubmed	Complementary and combinatorial patterns of Notch gene family expression during early mouse development.	NOTCH1 NOTCH3	6.07e-06	3	50	2	8645602
Pubmed	Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression.	NOTCH1 NOTCH3	6.07e-06	3	50	2	31346528
Pubmed	PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study.	NOTCH1 NOTCH3	6.07e-06	3	50	2	34846251
Pubmed	Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study.	NOTCH1 NOTCH3	6.07e-06	3	50	2	21471519
Pubmed	MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways.	MUC5AC NOTCH1	6.07e-06	3	50	2	21622856
Pubmed	Smooth muscle Notch1 mediates neointimal formation after vascular injury.	NOTCH1 NOTCH3	6.07e-06	3	50	2	19433762
Pubmed	Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.	RNF40 AR	6.07e-06	3	50	2	22155569
Pubmed	Effect of notch1,2,3 genes silicing on NF-κB signaling pathway of macrophages in patients with atherosclerosis.	NOTCH1 NOTCH3	6.07e-06	3	50	2	27697639
Pubmed	NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.	NOTCH1 NOTCH3	6.07e-06	3	50	2	20801121
Pubmed	Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells.	NOTCH1 NOTCH3	6.07e-06	3	50	2	18483410
Pubmed	KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.	NOTCH1 NOTCH3	6.07e-06	3	50	2	34854382
Pubmed	Overlapping but distinct roles for NOTCH receptors in human cardiovascular disease.	NOTCH1 NOTCH3	6.07e-06	3	50	2	29767458
Pubmed	The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation.	NOTCH1 NOTCH3	6.07e-06	3	50	2	7698746
Pubmed	Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations.	AR NOTCH1	6.07e-06	3	50	2	34232601
Pubmed	Hepatitis B virus X protein and hypoxia‑inducible factor-1α stimulate Notch gene expression in liver cancer cells.	NOTCH1 NOTCH3	6.07e-06	3	50	2	27840976
Pubmed	The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex.	CDC27 AR	6.07e-06	3	50	2	27312068
Pubmed	Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells.	NOTCH1 NOTCH3	6.07e-06	3	50	2	33664344
Pubmed	Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development.	CLDN3 NOTCH1 NOTCH3	7.10e-06	26	50	3	32467237
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	MUC5AC NOTCH1 NOTCH3	7.98e-06	27	50	3	21791528
Pubmed	Notch signaling in stomach epithelial stem cell homeostasis.	MUC5AC NOTCH1 NOTCH3	9.95e-06	29	50	3	21402740
Pubmed	Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.	NOTCH1 NOTCH3	1.21e-05	4	50	2	28061457
Pubmed	Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.	NOTCH1 NOTCH3	1.21e-05	4	50	2	21673954
Pubmed	The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.	NOTCH1 NOTCH3	1.21e-05	4	50	2	24145721
Pubmed	A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.	NOTCH1 NOTCH3	1.21e-05	4	50	2	20069356
Pubmed	Expression and clinical significance of Notch receptors in human renal cell carcinoma.	NOTCH1 NOTCH3	1.21e-05	4	50	2	19404845
Pubmed	Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.	NOTCH1 NOTCH3	1.21e-05	4	50	2	28669409
Pubmed	Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.	NOTCH1 NOTCH3	1.21e-05	4	50	2	10551863
Pubmed	Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis.	EPHX2 NOTCH3	1.21e-05	4	50	2	27266621
Pubmed	Evolutionary analysis of vertebrate Notch genes.	NOTCH1 NOTCH3	1.21e-05	4	50	2	11466531
Pubmed	Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.	NOTCH1 NOTCH3	1.21e-05	4	50	2	24151014
Pubmed	Activation of Notch signaling in human tongue carcinoma.	NOTCH1 NOTCH3	1.21e-05	4	50	2	20819128
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	MUC5AC NOTCH3	1.21e-05	4	50	2	22691042
Pubmed	Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.	NOTCH1 NOTCH3	1.21e-05	4	50	2	11401408
Pubmed	Novel MIR143-NOTCH fusions in benign and malignant glomus tumors.	NOTCH1 NOTCH3	1.21e-05	4	50	2	23999936
Pubmed	Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.	NOTCH1 NOTCH3	1.21e-05	4	50	2	29170450
Pubmed	Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.	NOTCH1 NOTCH3	1.21e-05	4	50	2	10194420
Pubmed	NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.	NOTCH1 NOTCH3	1.21e-05	4	50	2	18156632
Pubmed	Functional conservation of mouse Notch receptor family members.	NOTCH1 NOTCH3	1.21e-05	4	50	2	8898100
Pubmed	Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.	NOTCH1 TRIM3	1.21e-05	4	50	2	26893479
Pubmed	Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.	NOTCH1 NOTCH3	1.21e-05	4	50	2	11978185
Pubmed	Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.	NOTCH1 NOTCH3	1.21e-05	4	50	2	11459941
Pubmed	Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.	AR NOTCH1	1.21e-05	4	50	2	28178391
Pubmed	p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.	NOTCH1 NOTCH3	1.21e-05	4	50	2	12391150
Pubmed	Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.	NOTCH1 NOTCH3	1.21e-05	4	50	2	20829372
Pubmed	Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.	NOTCH1 NOTCH3	1.21e-05	4	50	2	18184405
Pubmed	CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.	NOTCH1 NOTCH3	1.21e-05	4	50	2	22705236
Pubmed	Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.	NOTCH1 NOTCH3	1.21e-05	4	50	2	20040020
Pubmed	Notch signaling in the mammalian central nervous system: insights from mouse mutants.	NOTCH1 NOTCH3	1.21e-05	4	50	2	15917835
Pubmed	TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer.	TRAF4 AR	1.21e-05	4	50	2	37155905
Pubmed	Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.	NOTCH1 NOTCH3	1.21e-05	4	50	2	23444212
Pubmed	Deregulated expression of Notch receptors in human hepatocellular carcinoma.	NOTCH1 NOTCH3	1.21e-05	4	50	2	17920003
Pubmed	Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.	NOTCH1 NOTCH3	1.21e-05	4	50	2	11044625
Pubmed	Notch signaling in bulge stem cells is not required for selection of hair follicle fate.	NOTCH1 NOTCH3	2.02e-05	5	50	2	19211676
Pubmed	A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.	NOTCH1 NOTCH3	2.02e-05	5	50	2	27040987
Pubmed	Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.	NOTCH1 NOTCH3	2.02e-05	5	50	2	11006133
Pubmed	Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.	NOTCH1 NOTCH3	2.02e-05	5	50	2	21124806
Pubmed	Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells.	NOTCH1 NOTCH3	2.02e-05	5	50	2	15879553
Pubmed	Functional diversity of notch family genes in fetal lung development.	NOTCH1 NOTCH3	2.02e-05	5	50	2	15064243
Pubmed	A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.	NOTCH1 NOTCH3	2.02e-05	5	50	2	21562564
Pubmed	Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).	NOTCH1 NOTCH3	2.02e-05	5	50	2	23675950
Pubmed	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.	NOTCH1 NOTCH3	2.02e-05	5	50	2	11101851
Pubmed	Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.	CLDN3 AR	2.02e-05	5	50	2	24825397
Pubmed	Notch expression in developing olfactory neuroepithelium.	NOTCH1 NOTCH3	2.02e-05	5	50	2	15076712
Pubmed	Notch3 drives development and progression of cholangiocarcinoma.	NOTCH1 NOTCH3	2.02e-05	5	50	2	27791012
Pubmed	Chimeric analysis of Notch2 function: a role for Notch2 in the development of the roof plate of the mouse brain.	NOTCH1 NOTCH3	2.02e-05	5	50	2	12242712
Pubmed	Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.	NOTCH1 NOTCH3	2.02e-05	5	50	2	15882997
Pubmed	Deficiency of Notch signaling in pericytes results in arteriovenous malformations.	NOTCH1 NOTCH3	2.02e-05	5	50	2	33148887
Pubmed	Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.	NOTCH1 NOTCH3	2.02e-05	5	50	2	20554499
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	MUC5AC NOTCH1 NOTCH3	2.87e-05	41	50	3	22675208
Pubmed	RBP-L, a transcription factor related to RBP-Jkappa.	NOTCH1 NOTCH3	3.03e-05	6	50	2	9111338
Pubmed	Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.	NOTCH1 NOTCH3	3.03e-05	6	50	2	20870902
Pubmed	The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.	NOTCH1 NOTCH3	3.03e-05	6	50	2	26062937
Pubmed	A study on Notch signaling in human breast cancer.	NOTCH1 NOTCH3	3.03e-05	6	50	2	17822320
Pubmed	The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity.	NOTCH1 NOTCH3	3.03e-05	6	50	2	11404076
Pubmed	ALDH maintains the stemness of lung adenoma stem cells by suppressing the Notch/CDK2/CCNE pathway.	NOTCH1 NOTCH3	3.03e-05	6	50	2	24671051
Pubmed	Characterization of Notch receptor expression in the developing mammalian heart and liver.	NOTCH1 NOTCH3	3.03e-05	6	50	2	12244553
Pubmed	Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.	NOTCH1 NOTCH3	3.03e-05	6	50	2	22526456
Pubmed	Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes.	NOTCH1 NOTCH3	3.03e-05	6	50	2	31249304
Cytoband	1p31.1	ASB17 ERICH3 SLC44A5	6.59e-05	71	50	3	1p31.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1p31	ASB17 ERICH3 SLC44A5 ALG6	1.07e-04	224	50	4	chr1p31
GeneFamily	Ring finger proteins	TRAF4 RAD18 TRIM54 RNF40 TRIM3	2.96e-04	275	39	5	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM54 CMYA5 TRIM3	1.12e-03	95	39	3	59
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB49 BNC2 SCAPER ZNF267 ZNF101 ZNF626	4.09e-03	718	39	6	28
Coexpression	SMID_BREAST_CANCER_ERBB2_UP	TRAF4 ATP2C2 SCNN1A AR TRIM3	1.05e-05	152	50	5	M3102
Coexpression	SMID_BREAST_CANCER_LUMINAL_A_UP	PCSK5 SCUBE2 CILP CHRDL1	2.12e-05	85	50	4	M7517
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM184A ATP2C2 SCNN1A ATP10B CMYA5 MUC5AC	5.01e-08	179	50	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TMEM184A ATP2C2 SCNN1A ATP10B CLDN3 MUC5AC	9.38e-08	199	50	6	7223f853335492ca617dbec3e4b6872a8a463a45
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TMEM184A ATP2C2 SCNN1A ATP10B CLDN3 MUC5AC	9.38e-08	199	50	6	e03bdc7cb825e287f41b834ec6061d23c1c03b04
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SCUBE2 SEMA6D TMEM184A SLC44A5 NOTCH3	1.78e-06	180	50	5	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TMEM184A SCNN1A CLDN3 MUC5AC CFAP65	1.87e-06	182	50	5	dc29e8735c3562ce32322351d28f7d9709208ebf
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM184A ATP2C2 SCNN1A CMYA5 MUC5AC	1.98e-06	184	50	5	01c19a830348ab0b9c02c1546a439de70ee10f97
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	BNC2 SCUBE2 SEMA6D CILP CHRDL1	2.03e-06	185	50	5	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM184A ATP2C2 SCNN1A CMYA5 MUC5AC	2.31e-06	190	50	5	3c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM184A ATP2C2 SCNN1A CMYA5 MUC5AC	2.31e-06	190	50	5	23f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM184A ATP2C2 SCNN1A CLDN3 CFAP65	2.50e-06	193	50	5	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 SCNN1A CLDN3 MUC5AC CFAP65	2.50e-06	193	50	5	aa10924b203c71e65fdbd2b90ba131dbd362d8b1
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM184A SCNN1A ATP10B CLDN3 NOTCH3	2.50e-06	193	50	5	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM184A ATP2C2 SCNN1A CLDN3 CFAP65	2.50e-06	193	50	5	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	STX19 SCNN1A ATP10B CLDN3 MUC5AC	2.63e-06	195	50	5	b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STX19 ATP2C2 SCNN1A CLDN3 CFAP65	2.63e-06	195	50	5	09605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STX19 ATP2C2 SCNN1A CLDN3 CFAP65	2.63e-06	195	50	5	7ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell	distal-Epithelial-Goblet\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ATP2C2 ATP10B CLDN3 CMYA5 MUC5AC	2.76e-06	197	50	5	da1ed7303cc9cb2d205c0e5c49c52544d3540951
ToppCell	COVID-19-Epithelial\|COVID-19 / Condition, Lineage and Cell class	ERICH3 ATP2C2 SCNN1A CLDN3 CFAP65	2.76e-06	197	50	5	18fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell	Bronchus_Control_(B.)\|World / Sample group, Lineage and Cell type	TMEM184A ZNF267 ATP10B CMYA5 MUC5AC	2.76e-06	197	50	5	b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCell	distal-Epithelial-Goblet-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ATP2C2 ATP10B CLDN3 CMYA5 MUC5AC	2.76e-06	197	50	5	3fbf456ae4f73da4f6254a6f0d24f0ec27d7a3cc
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SCUBE2 SLC44A5 SCNN1A MUC5AC NOTCH3	2.83e-06	198	50	5	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TMEM184A ATP2C2 SCNN1A ATP10B MUC5AC	2.90e-06	199	50	5	a706ad5cd5e0dc8d7e925a05e45b07d35963f294
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Club\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	TMEM184A ATP2C2 SCNN1A CMYA5 MUC5AC	2.97e-06	200	50	5	292c63693eb7f435335a8cfba07aa35b72139393
ToppCell	Bronchus_Control_(B.)-Epithelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ERICH3 ATP2C2 SCNN1A CLDN3 MUC5AC	2.97e-06	200	50	5	f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ToppCell	TCGA-Breast\|World / Sample_Type by Project: Shred V9	SCUBE2 CILP CLPSL1 AR	2.43e-05	150	50	4	08686ba1acac5c58667bf62e2af84c691d6bbdfb
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP2C2 SCNN1A CLDN3 CFAP65	3.12e-05	160	50	4	028b5261a1da832d52f66fb620db83e5fbbd874a
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP2C2 SCNN1A CLDN3 CFAP65	3.12e-05	160	50	4	1f4ee446436726c3d373f56d87dd80b6a12e8b9e
ToppCell	Club-club-12\|World / Class top	ATP2C2 CLDN3 MUC5AC TRIM3	3.52e-05	165	50	4	9b7a31cbdcd2f96b8bd08a4cd4141b92bd5e9062
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 ATP10B CLDN3 CFAP65	3.52e-05	165	50	4	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 ATP10B CLDN3 CFAP65	3.52e-05	165	50	4	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	TMEM184A ATP2C2 MUC5AC AR	3.69e-05	167	50	4	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCNN1A CLDN3 TRIM3 CFAP65	3.96e-05	170	50	4	9bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCNN1A CLDN3 TRIM3 CFAP65	3.96e-05	170	50	4	2c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor-MUC5AC+ASCL1+_intermediate_\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	STX19 SCNN1A CLDN3 MUC5AC	3.96e-05	170	50	4	d6e244725b21592c6056b9c443aac090f1eae836
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCNN1A CLDN3 MUC5AC CFAP65	4.33e-05	174	50	4	e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC44A5 CILP CHRDL1 ATP10B	4.33e-05	174	50	4	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC44A5 CILP CHRDL1 ATP10B	4.33e-05	174	50	4	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCNN1A CLDN3 MUC5AC CFAP65	4.33e-05	174	50	4	ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 CHRDL1	4.84e-05	179	50	4	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRAF4 TMEM184A SLC44A5 SCNN1A	5.16e-05	182	50	4	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	droplet-Lung-LUNG-1m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STX19 TMEM184A SCNN1A CLDN3	5.16e-05	182	50	4	c1e0be27064e14043b78ae501b02d4e9542267a3
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STX19 TMEM184A SCNN1A CLDN3	5.16e-05	182	50	4	3c9b4869d357884ae4bcd22a9872faf83a5cfc6d
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCNN1A ATP10B CLDN3 MUC5AC	5.27e-05	183	50	4	514b72a1ae55656934839800513385e19bc240e2
ToppCell	NS-critical-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 STAB2 SCUBE2 AR	5.27e-05	183	50	4	ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 CHRDL1	5.27e-05	183	50	4	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCNN1A ATP10B CLDN3 MUC5AC	5.38e-05	184	50	4	49eccf72725593a8fb4a529e7985a5c413b3ca6a
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCNN1A ATP10B CLDN3 MUC5AC	5.38e-05	184	50	4	41164109d9d7bb1c431220e2e85e08dc5f56856d
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP2C2 SCNN1A CLDN3 CFAP65	5.38e-05	184	50	4	886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-CD8+_T_naive\|COVID-19_Convalescent / Disease group, lineage and cell class	PCSK5 EPHX2 DSC1 PIWIL1	5.38e-05	184	50	4	0299cd30a3ea8e861a9d529043c204048ae21d29
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP2C2 SCNN1A CLDN3 CFAP65	5.38e-05	184	50	4	936b39377eebea3961d702532779f6cd27953be7
ToppCell	critical-Epithelial-Ionocyte\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 STAB2 SCUBE2 AR	5.38e-05	184	50	4	58d36577eff814d46d72f031f3533d71549e3d6e
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	PCSK5 EPHX2 DSC1 PIWIL1	5.50e-05	185	50	4	863a3d44c1f115942d7a2a2b63a92fe5fc768814
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 CHRDL1	5.50e-05	185	50	4	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 CHRDL1	5.50e-05	185	50	4	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PCSK5 EPHX2 DSC1 PIWIL1	5.50e-05	185	50	4	27dbfcd40ec832d5cf757331d8af3b5176ae90fb
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PCSK5 EPHX2 DSC1 PIWIL1	5.50e-05	185	50	4	1c23891e4d75f99296d1304af7a9d6c3cb28d04c
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PCSK5 EPHX2 DSC1 PIWIL1	5.50e-05	185	50	4	ca8e921a6b45cd39474b9f86c95e7be023585c5d
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ATP2C2 SANBR CLDN3 MUC5AC	5.73e-05	187	50	4	82bbc107f58c623f3b90430c90c562624a12abef
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM184A ATP2C2 SCNN1A MUC5AC	5.85e-05	188	50	4	5901b276f2379abf486b8285957277e95f08464e
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 ATP2C2 CLDN3 AR	5.85e-05	188	50	4	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 SCNN1A CLDN3 MUC5AC	5.85e-05	188	50	4	3cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 ATP2C2 CLDN3 VWDE	5.97e-05	189	50	4	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 BNC2 CHRDL1 NOTCH3	5.97e-05	189	50	4	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 BNC2 CHRDL1 NOTCH3	5.97e-05	189	50	4	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PCSK5 SCUBE2 CILP TRIM54	6.10e-05	190	50	4	3aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP10B CLDN3 NOTCH1 NOTCH3	6.10e-05	190	50	4	0bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERICH3 ATP10B MUC5AC CFAP65	6.10e-05	190	50	4	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	7b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	STX19 SLC44A5 SCNN1A CLDN3	6.22e-05	191	50	4	63aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	9f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCell	Control-Epithelial\|Control / Disease group,lineage and cell class （2021.01.30）	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	b78547dae8328244a47c83346447bdd787efbcae
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 SCNN1A CLDN3 MUC5AC	6.22e-05	191	50	4	05731ece7867659c662f952812805f947032fe10
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SCUBE2 TMEM184A SLC44A5 SCNN1A	6.22e-05	191	50	4	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	b4e335e798c9617356b8e24412f9270c42dce656
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	c4b223b33c020a064f576711a3d700eb60a2d737
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	5129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCell	Control-Epithelial-Ciliated\|Control / Disease group,lineage and cell class （2021.01.30）	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	ERICH3 ATP2C2 CLDN3 CFAP65	6.22e-05	191	50	4	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 SCNN1A CLDN3 MUC5AC	6.35e-05	192	50	4	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SCNN1A CLDN3 VWDE CFAP65	6.48e-05	193	50	4	8603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SCNN1A TRIM54 CLDN3 VWDE	6.48e-05	193	50	4	44839a606ae2f8e37421bda46d588189e1c943d2
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STX19 ATP2C2 SCNN1A CLDN3	6.61e-05	194	50	4	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STX19 SCNN1A CLDN3 CFAP65	6.61e-05	194	50	4	1a188e52f2f0b6eca3e8d4a4671d9beab0fbbb88
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STX19 ATP2C2 SCNN1A CLDN3	6.61e-05	194	50	4	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ERICH3 SCNN1A CLDN3 CFAP65	6.61e-05	194	50	4	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLC44A5 ATP2C2 CLDN3 AR	6.61e-05	194	50	4	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP2C2 SCNN1A ATP10B CLDN3	6.74e-05	195	50	4	c5f33b420c9ac14dc67fea632b8c2bc2442cbf3d
ToppCell	Nasal_Brush\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	SCNN1A ATP10B MUC5AC FBXO34	6.74e-05	195	50	4	7509b980b6b293df02bec619ef5b83a6c7b49c03
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCNN1A ATP10B CLDN3 NOTCH3	6.74e-05	195	50	4	25703e3c2e0512ef12e7aa389fad3968c3f13905
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STX19 SCNN1A CLDN3 CFAP65	6.74e-05	195	50	4	3365768101454060b9ea96ef6b426c76c150bc8f
ToppCell	distal-Epithelial-Differentiating_Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	STX19 TRAF4 CLDN3 CMYA5	6.74e-05	195	50	4	3fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCSK5 BNC2 CILP CHRDL1	6.74e-05	195	50	4	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCUBE2 ATP2C2 ATP10B CLDN3	6.74e-05	195	50	4	b67d4f34cae729c18275486d3b20c9dd7d5cbe79
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-Goblet_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP2C2 SCNN1A ATP10B CLDN3	6.74e-05	195	50	4	219c5d0cde7f6082755154f54db221413ec555cb
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM184A ATP2C2 SCNN1A MUC5AC	6.88e-05	196	50	4	c18874f37b90e6afacc562b2082b67ea8a7cb4a4
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP2C2 TRIM54 ATP10B CLDN3	6.88e-05	196	50	4	97324c9e93f833e1f218e81fb53066d44c6892df
Drug	Viomycin sulfate [37883-00-4]; Down 200; 5.2uM; PC3; HT_HG-U133A	EPHX2 TRAF4 ATP2C2 CLDN3 TRIM3 NOTCH3	4.37e-06	196	50	6	7278_DN
Drug	16 alpha,17-epoxyprogesterone	EPHX2 AR	4.73e-06	2	50	2	ctd:C028108
Drug	D-CW	EPHX2 AR	1.42e-05	3	50	2	CID000004277
Disease	adenocarcinoma (implicated_via_orthology)	NOTCH1 NOTCH3	5.88e-05	7	50	2	DOID:299 (implicated_via_orthology)
Disease	central nervous system cancer (implicated_via_orthology)	NOTCH1 NOTCH3	5.88e-05	7	50	2	DOID:3620 (implicated_via_orthology)
Disease	cis-4-decenoylcarnitine (C10:1) measurement	ASB17 SLC44A5	7.83e-05	8	50	2	EFO_0800311
Disease	skin pigmentation measurement	ADAMTS12 BNC2 SEMA6D DEF8	8.68e-05	137	50	4	EFO_0007009
Disease	decanoylcarnitine measurement	ASB17 SLC44A5	1.84e-04	12	50	2	EFO_0021039
Disease	squamous cell carcinoma	ADAMTS12 BNC2 DEF8	2.03e-04	67	50	3	EFO_0000707
Disease	skin pigmentation	BNC2 DEF8 USP48	2.22e-04	69	50	3	EFO_0003784
Disease	actinic keratosis	BNC2 DEF8	2.53e-04	14	50	2	EFO_0002496
Disease	Carcinoma, Pancreatic Ductal	NOTCH1 NOTCH3	7.58e-04	24	50	2	C0887833
Disease	Cerebral Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0750935
Disease	Intracranial Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0750936
Disease	Pilocytic Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0334583
Disease	Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0280783
Disease	Diffuse Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0280785
Disease	Grade I Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0205768
Disease	Mixed oligoastrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0547065
Disease	Childhood Cerebral Astrocytoma	AR NOTCH1	8.23e-04	25	50	2	C0338070
Disease	brain cancer (implicated_via_orthology)	NOTCH1 NOTCH3	8.91e-04	26	50	2	DOID:1319 (implicated_via_orthology)
Disease	Gemistocytic astrocytoma	AR NOTCH1	8.91e-04	26	50	2	C0334581
Disease	Protoplasmic astrocytoma	AR NOTCH1	8.91e-04	26	50	2	C0334580
Disease	Fibrillary Astrocytoma	AR NOTCH1	8.91e-04	26	50	2	C0334582
Disease	Anaplastic astrocytoma	AR NOTCH1	9.61e-04	27	50	2	C0334579
Disease	colorectal cancer (implicated_via_orthology)	NOTCH1 NOTCH3	1.19e-03	30	50	2	DOID:9256 (implicated_via_orthology)
Disease	intestinal cancer (implicated_via_orthology)	NOTCH1 NOTCH3	1.35e-03	32	50	2	DOID:10155 (implicated_via_orthology)
Disease	cannabis dependence	EPHX2 SEMA6D ATP10B	1.57e-03	135	50	3	EFO_0007191

Protein segments in the cluster

Peptide	Gene	Start	Entry
VCVERSSPCYKCIIA	ERICH3	386	Q5RHP9
EYKARLTCPCCNTRK	RNF40	941	O75150
LCSSPDPKICYVCKK	BNC2	826	Q6ZN30
PAVVLYCCCLKEIST	ALG6	126	Q9Y672
PTKSLVALKCTCCYF	FBXO34	591	Q9NWN3
LKLCEKYCCSPKRVQ	ATP2C2	926	O75185
YCRSVLCCRSTPLQK	ATP10B	1021	O94823
KKCSVPTVRAECCFS	ADAMTS12	1556	P58397
RKFLSYKTQCPTCCV	RAD18	51	Q9NS91
TCDLLTLTEYKCRCP	NOTCH1	116	P46531
TCCTACEPARKYKTL	CFAP65	1561	Q6ZU64
KLCGKTSCPRSNIFC	ASB17	6	Q8WXJ9
YKLKNNTRICVSSCP	PCSK5	661	Q92824
KCLDLVDKYLCRCPS	NOTCH3	596	Q9UM47
SYTRPTVCQACKKLL	PRKD2	271	Q9BZL6
YVCGKTINLLKLCCP	TUBGCP6	596	Q96RT7
CLNYEVRVLCCETPK	MUC5AC	4041	P98088
DCTIDKFRRKNCPSC	AR	601	P10275
RSSKCCCIYEKPRAF	PPP1R11	56	O60927
CRKCSETAKVCLPKN	EPHX2	71	P34913
NVYCGLKTCPKLTCA	CHRDL1	151	Q9BU40
RACPCLRNLTCIYSK	CLPSL1	81	A2RUU4
KSQIDTYCYTCKCPI	CMYA5	3506	Q8N3K9
YRCHSKCLNLISKPC	DEF8	236	Q6ZN54
CFCVTAKRTVKKCFP	DSC1	711	Q08554
CPTTQICVSKCPEKF	SLC44A5	111	Q8NCS7
LCQNTPTSYKCSCKP	SCUBE2	61	Q9NQ36
CFTKCRKPCSVTSYQ	SCNN1A	471	P37088
TPYERKKQCSLCNVL	SCAPER	786	Q9BY12
CTTPQCKYLLAKCCV	CDC27	66	P30260
PKRSLCYCESCRKLR	NEURL4	1361	Q96JN8
IKKYLCTDCPTPSQC	PIWIL1	571	Q96J94
KPIKSSCLYGTCCLR	TMEM184A	156	Q6ZMB5
AATLYRCCLCKKLLT	SANBR	321	Q6NSI8
CCSCPPREKKYTATK	CLDN3	181	O15551
TLPTKVAKECSCQRC	CILP	471	O75339
IYCLSCEVPTCSLCK	TRIM54	136	Q9BYV2
TICKYPCGKSRECVA	VWDE	1296	Q8N2E2
AVKYKKRNPCRVLCC	STX19	271	Q8N4C7
SYKCNKCVEVCTQSL	ZNF267	266	Q14586
ARYCNATVKIPKCCK	STAB2	716	Q8WWQ8
SECPKRTQPCTYCTK	TRAF4	186	Q9BUZ4
CLTTTPRKICQCDKY	ZNF626	136	Q68DY1
ECQKCAKVFRCPTSL	ZNF101	311	Q8IZC7
KPYTCEICNKCFTRS	ZBTB49	561	Q6ZSB9
PLSRCERYGSCKKSC	SEMA6D	511	Q8NFY4
PSYKECCSQCKILER	USP48	686	Q86UV5
CSTVVCVICLEKPKY	ZNHIT3	6	Q15649
VCSICLDRYQCPKVL	TRIM3	21	O75382
KKNSCYTLLEVLCPC	KDM5C	1091	P41229