Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

COL4A2 THBS1 RELN HMCN1 LAMC2 COL22A1 EDIL3 TNXB FBN3

2.16e-08188719GO:0005201
GeneOntologyMolecularFunctioncalcium ion binding

THBS1 NOTCH2NLB HMCN1 MEGF6 PLA2G12A LRP1 BCAN LTBP3 PLA2G2F PLA2G2C EDIL3 VWA2 FBN3 NOTCH2 CRB2

4.61e-087497115GO:0005509
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF250 ZNF274 ZNF358 ZNF423 ESRRB ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 RFXAP ZNF251 ZKSCAN5 NOTCH2 ZNF286A

2.79e-0514127116GO:0000981
GeneOntologyMolecularFunctioncalcium-dependent phospholipase A2 activity

PLA2G12A PLA2G2F PLA2G2C

3.38e-0518713GO:0047498
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF250 ZNF274 ZNF358 ZNF423 ESRRB ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF251 ZKSCAN5 NOTCH2 ZNF286A

1.31e-0412717114GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF250 ZNF274 ZNF358 ZNF423 ESRRB ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 RFXAP ZNF251 ZKSCAN5 ZNF286A

1.56e-0414597115GO:0000977
GeneOntologyMolecularFunctionphospholipase A2 activity

PLA2G12A PLA2G2F PLA2G2C

3.07e-0437713GO:0004623
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF250 ZNF274 ZNF358 ZNF423 ESRRB ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF251 ZKSCAN5 ZNF286A

3.93e-0412447113GO:0000978
GeneOntologyMolecularFunctionintegrin binding

THBS1 EGFR EDIL3 TNXB ITGB5

3.98e-04175715GO:0005178
GeneOntologyMolecularFunctionphospholipase activity

PLA2G12A PLA2G2F PLA2G2C BDKRB2

7.29e-04114714GO:0004620
GeneOntologyMolecularFunctionzinc ion binding

PAPPA2 PRICKLE4 ZCCHC9 POLR3B ADAMTS9 ESRRB BHMT2 BIRC2 ZKSCAN5 PHF5A

1.16e-038917110GO:0008270
GeneOntologyMolecularFunctionlipase activity

PLA2G12A PLA2G2F PLA2G2C BDKRB2

1.48e-03138714GO:0016298
GeneOntologyMolecularFunctiongrowth factor binding

THBS1 EGFR SCN5A LTBP3

2.32e-03156714GO:0019838
GeneOntologyMolecularFunctionglycosaminoglycan binding

THBS1 TENM1 LAMC2 BCAN TNXB

2.66e-03268715GO:0005539
GeneOntologyMolecularFunctioncollagen binding

THBS1 USH2A TNXB

3.01e-0381713GO:0005518
GeneOntologyMolecularFunctioncysteine-type endopeptidase inhibitor activity involved in apoptotic process

BIRC2 BIRC3

3.27e-0324712GO:0043027
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF358 ESRRB ZNF629 ZNF112 ZNF229 RFXAP NOTCH2

3.71e-03560717GO:0001228
GeneOntologyMolecularFunctiontransforming growth factor beta binding

THBS1 LTBP3

3.83e-0326712GO:0050431
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF358 ESRRB ZNF629 ZNF112 ZNF229 RFXAP NOTCH2

3.93e-03566717GO:0001216
GeneOntologyMolecularFunctionNotch binding

NOTCH2NLB MEGF10

4.13e-0327712GO:0005112
GeneOntologyMolecularFunctionscavenger receptor activity

LRP1 MEGF10

4.13e-0327712GO:0005044
GeneOntologyMolecularFunctionfibroblast growth factor binding

THBS1 SCN5A

4.13e-0327712GO:0017134
GeneOntologyMolecularFunctionstructural molecule activity

COL4A2 THBS1 RELN HMCN1 LAMC2 COL22A1 EDIL3 TNXB FBN3

4.20e-03891719GO:0005198
GeneOntologyMolecularFunctionheparin binding

THBS1 TENM1 LAMC2 TNXB

4.87e-03192714GO:0008201
GeneOntologyBiologicalProcesscell-matrix adhesion

PCSK5 THBS1 ADAMTS9 LRP1 BCAN VWA2 TNXB ITGB5

3.64e-06270708GO:0007160
GeneOntologyBiologicalProcesslong-chain fatty acid transport

THBS1 PLA2G12A PLA2G2F PLA2G2C BDKRB2

5.23e-0674705GO:0015909
GeneOntologyBiologicalProcessarachidonate secretion

PLA2G12A PLA2G2F PLA2G2C BDKRB2

6.60e-0636704GO:0050482
GeneOntologyBiologicalProcessarachidonate transport

PLA2G12A PLA2G2F PLA2G2C BDKRB2

6.60e-0636704GO:1903963
GeneOntologyBiologicalProcesscell-substrate adhesion

PCSK5 THBS1 ADAMTS9 LRP1 BCAN EDIL3 VWA2 TNXB ITGB5

9.89e-06410709GO:0031589
GeneOntologyBiologicalProcessicosanoid secretion

PLA2G12A PLA2G2F PLA2G2C BDKRB2

3.91e-0556704GO:0032309
GeneOntologyBiologicalProcessfatty acid transport

THBS1 PLA2G12A PLA2G2F PLA2G2C BDKRB2

8.63e-05132705GO:0015908
GeneOntologyBiologicalProcessicosanoid transport

PLA2G12A PLA2G2F PLA2G2C BDKRB2

1.11e-0473704GO:0071715
GeneOntologyCellularComponentcollagen-containing extracellular matrix

COL4A2 THBS1 RELN HMCN1 MEGF6 ADAMTS9 LAMC2 BCAN LTBP3 COL22A1 EDIL3 VWA2 USH2A TNXB

2.45e-095307114GO:0062023
GeneOntologyCellularComponentextracellular matrix

COL4A2 THBS1 RELN HMCN1 MEGF6 ADAMTS9 LAMC2 BCAN LTBP3 COL22A1 EDIL3 VWA2 USH2A TNXB FBN3

4.32e-096567115GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

COL4A2 THBS1 RELN HMCN1 MEGF6 ADAMTS9 LAMC2 BCAN LTBP3 COL22A1 EDIL3 VWA2 USH2A TNXB FBN3

4.50e-096587115GO:0030312
GeneOntologyCellularComponentbasement membrane

COL4A2 HMCN1 LAMC2 VWA2 USH2A

5.97e-05122715GO:0005604
MousePhenoabnormal pinna cartilage morphology

LAMC2 EDIL3

1.46e-052542MP:0030423
DomainEGF

PCSK5 THBS1 RELN HMCN1 MEGF6 TENM1 LRP1 LAMC2 BCAN LTBP3 EDIL3 VWA2 TNXB ITGB5 FBN3 MEGF10 NOTCH2 CRB2

3.16e-192356918SM00181
DomainEGF_1

THBS1 RELN HMCN1 MEGF6 TENM1 LRP1 LAMC2 BCAN LTBP3 EDIL3 VWA2 USH2A TNXB ITGB5 FBN3 MEGF10 NOTCH2 CRB2

1.38e-182556918PS00022
DomainEGF-like_dom

PCSK5 THBS1 RELN HMCN1 MEGF6 TENM1 LRP1 LAMC2 BCAN LTBP3 EDIL3 VWA2 TNXB FBN3 MEGF10 NOTCH2 CRB2

2.47e-172496917IPR000742
DomainEGF-like_CS

THBS1 RELN HMCN1 MEGF6 TENM1 LRP1 LAMC2 BCAN LTBP3 EDIL3 VWA2 TNXB ITGB5 FBN3 MEGF10 NOTCH2 CRB2

5.46e-172616917IPR013032
DomainEGF_2

THBS1 RELN HMCN1 MEGF6 TENM1 LRP1 LAMC2 BCAN LTBP3 EDIL3 VWA2 TNXB ITGB5 FBN3 MEGF10 NOTCH2 CRB2

7.06e-172656917PS01186
DomainEGF_3

THBS1 RELN HMCN1 MEGF6 TENM1 LRP1 BCAN LTBP3 EDIL3 VWA2 TNXB FBN3 MEGF10 NOTCH2 CRB2

6.22e-152356915PS50026
DomainEGF

HMCN1 MEGF6 LRP1 BCAN EDIL3 VWA2 TNXB ITGB5 FBN3 NOTCH2 CRB2

1.11e-121266911PF00008
DomainhEGF

MEGF6 LTBP3 EDIL3 FBN3 MEGF10 NOTCH2 CRB2

7.65e-1228697PF12661
DomainEGF_CA

THBS1 HMCN1 MEGF6 LRP1 LTBP3 EDIL3 VWA2 FBN3 NOTCH2 CRB2

2.39e-111226910SM00179
DomainEGF-like_Ca-bd_dom

THBS1 HMCN1 MEGF6 LRP1 LTBP3 EDIL3 VWA2 FBN3 NOTCH2 CRB2

2.81e-111246910IPR001881
DomainGrowth_fac_rcpt_

PCSK5 HMCN1 MEGF6 EGFR LRP1 LAMC2 LTBP3 TNXB FBN3 NOTCH2

2.75e-101566910IPR009030
DomainEGF_extracell

RELN MEGF6 TENM1 EDIL3 TNXB ITGB5 MEGF10

2.27e-0960697IPR013111
DomainEGF_2

RELN MEGF6 TENM1 EDIL3 TNXB ITGB5 MEGF10

2.27e-0960697PF07974
DomainEGF_Ca-bd_CS

HMCN1 MEGF6 LRP1 LTBP3 EDIL3 FBN3 NOTCH2 CRB2

2.54e-0997698IPR018097
DomainEGF_CA

HMCN1 MEGF6 LRP1 LTBP3 EDIL3 FBN3 NOTCH2 CRB2

3.00e-0999698PS01187
DomainASX_HYDROXYL

HMCN1 MEGF6 LRP1 LTBP3 EDIL3 FBN3 NOTCH2 CRB2

3.25e-09100698PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

HMCN1 MEGF6 LRP1 LTBP3 EDIL3 FBN3 NOTCH2 CRB2

5.17e-09106698IPR000152
DomainEGF_CA

THBS1 HMCN1 MEGF6 LRP1 LTBP3 FBN3 NOTCH2

2.93e-0886697PF07645
DomainZINC_FINGER_C2H2_2

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 HELZ2 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

7.39e-077756914PS50157
DomainZINC_FINGER_C2H2_1

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 HELZ2 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

7.62e-077776914PS00028
DomainZnf_C2H2-like

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 HELZ2 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

1.02e-067966914IPR015880
Domain-

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

1.02e-0667969133.30.160.60
DomainZnF_C2H2

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 HELZ2 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

1.21e-068086914SM00355
DomainZnf_C2H2/integrase_DNA-bd

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

1.31e-066946913IPR013087
DomaincEGF

HMCN1 LRP1 LTBP3 FBN3

2.40e-0626694IPR026823
DomaincEGF

HMCN1 LRP1 LTBP3 FBN3

2.40e-0626694PF12662
DomainKRAB

ZNF250 ZNF274 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

6.50e-06358699PS50805
DomainKRAB

ZNF250 ZNF274 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

6.50e-06358699PF01352
DomainZnf_C2H2

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

6.64e-068056913IPR007087
Domainzf-C2H2

ZNF250 ZNF274 ZNF358 ZNF423 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

7.84e-066936912PF00096
Domain-

HMCN1 CACHD1 COL22A1 VWA2 ITGB5

7.85e-06746953.40.50.410
DomainLaminin_EGF

MEGF6 LAMC2 USH2A MEGF10

8.19e-0635694PF00053
DomainEGF_Lam

MEGF6 LAMC2 USH2A MEGF10

8.19e-0635694SM00180
DomainKRAB

ZNF250 ZNF274 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

8.29e-06369699SM00349
DomainKRAB

ZNF250 ZNF274 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

8.47e-06370699IPR001909
DomainLaminin_EGF

MEGF6 LAMC2 USH2A MEGF10

1.15e-0538694IPR002049
DomainVWFA

HMCN1 CACHD1 COL22A1 VWA2 ITGB5

1.30e-0582695PS50234
DomainVWA

HMCN1 CACHD1 COL22A1 VWA2 ITGB5

1.46e-0584695SM00327
Domainzf-C2H2_6

ZNF250 ZNF358 ZNF423 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

2.00e-05314698PF13912
DomainVWF_A

HMCN1 CACHD1 COL22A1 VWA2 ITGB5

3.25e-0599695IPR002035
DomainSCAN

ZNF274 ZSCAN18 ZNF202 ZKSCAN5

5.42e-0556694SM00431
DomainSCAN_BOX

ZNF274 ZSCAN18 ZNF202 ZKSCAN5

6.23e-0558694PS50804
DomainLaminin_G

THBS1 COL22A1 USH2A CRB2

6.23e-0558694IPR001791
DomainSCAN

ZNF274 ZSCAN18 ZNF202 ZKSCAN5

6.23e-0558694PF02023
DomainSCAN_dom

ZNF274 ZSCAN18 ZNF202 ZKSCAN5

6.23e-0558694IPR003309
DomainRetrov_capsid_C

ZNF274 ZSCAN18 ZNF202 ZKSCAN5

6.66e-0559694IPR008916
DomainLamGL

PAPPA2 USH2A

8.03e-054692SM00560
DomainLamG-like

PAPPA2 USH2A

8.03e-054692IPR006558
DomainGF_recep_IV

PCSK5 EGFR

2.00e-046692PF14843
DomainGF_recep_IV

PCSK5 EGFR

2.00e-046692IPR032778
DomainTB

LTBP3 FBN3

2.79e-047692PF00683
DomainNotch_dom

PAPPA2 NOTCH2

2.79e-047692IPR000800
DomainNotch

PAPPA2 NOTCH2

2.79e-047692PF00066
DomainNL

PAPPA2 NOTCH2

2.79e-047692SM00004
DomainBIR

BIRC2 BIRC3

3.71e-048692SM00238
Domain-

BIRC2 BIRC3

3.71e-0486921.10.1170.10
DomainBIR

BIRC2 BIRC3

3.71e-048692PF00653
DomainBIR_REPEAT_2

BIRC2 BIRC3

3.71e-048692PS50143
Domain-

LTBP3 FBN3

3.71e-0486923.90.290.10
DomainBIR_rpt

BIRC2 BIRC3

3.71e-048692IPR001370
DomainBIR_REPEAT_1

BIRC2 BIRC3

3.71e-048692PS01282
Domain-

PAPPA2 THBS1 USH2A CRB2

4.22e-04956942.60.120.200
DomainTB

LTBP3 FBN3

4.76e-049692PS51364
DomainTB_dom

LTBP3 FBN3

4.76e-049692IPR017878
DomainPLipase_A2_His_AS

PLA2G12A PLA2G2F

5.94e-0410692IPR033113
DomainPA2_HIS

PLA2G12A PLA2G2F

7.24e-0411692PS00118
DomainPA2_ASP

PLA2G12A PLA2G2F

7.24e-0411692PS00119
DomainPLipase_A2_dom

PLA2G12A PLA2G2F

8.67e-0412692IPR016090
Domain-

PLA2G12A PLA2G2F

8.67e-04126921.20.90.10
DomainVWA

CACHD1 COL22A1 VWA2

1.16e-0356693PF00092
DomainConA-like_dom

PAPPA2 THBS1 COL22A1 USH2A CRB2

1.29e-03219695IPR013320
DomainCARD

BIRC2 BIRC3

1.56e-0316692SM00114
DomainEMI_domain

MEGF6 MEGF10

1.56e-0316692IPR011489
DomainTSP_1

THBS1 HMCN1 ADAMTS9

1.64e-0363693PF00090
DomainEMI

MEGF6 MEGF10

1.76e-0317692PS51041
DomainTSP1

THBS1 HMCN1 ADAMTS9

1.79e-0365693SM00209
DomainTSP1_rpt

THBS1 HMCN1 ADAMTS9

1.79e-0365693IPR000884
DomainTSP1

THBS1 HMCN1 ADAMTS9

1.79e-0365693PS50092
DomainFurin_repeat

PCSK5 EGFR

1.98e-0318692IPR006212
DomainFU

PCSK5 EGFR

1.98e-0318692SM00261
DomainTSPN

THBS1 COL22A1

3.24e-0323692SM00210
DomainC2H2_Znf_fam

ZSCAN18 ZNF202

3.52e-0324692IPR027775
PathwayWP_FOCAL_ADHESION

COL4A2 THBS1 RELN EGFR BIRC2 BIRC3 LAMC2 TNXB ITGB5

3.94e-08187559MM15913
PathwayWP_FOCAL_ADHESION

COL4A2 THBS1 RELN EGFR BIRC2 BIRC3 LAMC2 TNXB ITGB5

6.74e-08199559M39402
PathwayKEGG_FOCAL_ADHESION

COL4A2 THBS1 RELN EGFR BIRC2 BIRC3 LAMC2 TNXB ITGB5

6.74e-08199559M7253
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A2 THBS1 ADAMTS9 LAMC2 BCAN LTBP3 COL22A1 TNXB ITGB5 FBN3

2.06e-073005510M610
PathwayKEGG_ECM_RECEPTOR_INTERACTION

COL4A2 THBS1 RELN LAMC2 TNXB ITGB5

8.57e-0784556M7098
PathwayWP_MIRNA_TARGETS_IN_ECM_AND_MEMBRANE_RECEPTORS

COL4A2 THBS1 TNXB ITGB5

2.29e-0543554M39565
PathwayKEGG_ALPHA_LINOLENIC_ACID_METABOLISM

PLA2G12A PLA2G2F PLA2G2C

5.21e-0519553M311
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A2 THBS1 MEGF6 BCAN LTBP3 COL22A1 TNXB

6.08e-05258557MM14572
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

COL4A2 THBS1 LAMC2 ITGB5

8.05e-0559554M27218
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

COL4A2 THBS1 RELN EGFR LAMC2 TNXB ITGB5

1.62e-04302557M39719
PathwayKEGG_LINOLEIC_ACID_METABOLISM

PLA2G12A PLA2G2F PLA2G2C

1.91e-0429553M2920
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A2 ADAMTS9 LAMC2 BCAN FBN3

2.10e-04140555M587
PathwayREACTOME_ECM_PROTEOGLYCANS

COL4A2 BCAN TNXB ITGB5

2.16e-0476554M27219
PathwayWP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY

COL4A2 THBS1 RELN EGFR LAMC2 TNXB ITGB5

2.59e-04326557MM15917
PathwayKEGG_ETHER_LIPID_METABOLISM

PLA2G12A PLA2G2F PLA2G2C

2.82e-0433553M2130
PathwayKEGG_SMALL_CELL_LUNG_CANCER

COL4A2 BIRC2 BIRC3 LAMC2

3.17e-0484554M3228
PathwayWP_PI3KAKT_SIGNALING

COL4A2 THBS1 RELN EGFR LAMC2 TNXB ITGB5

3.29e-04339557M39736
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP3 ITGB5 FBN3

3.98e-0437553M27134
PathwayWP_SMALL_CELL_LUNG_CANCER

COL4A2 BIRC2 BIRC3 LAMC2

5.28e-0496554M39834
PathwayPID_UPA_UPAR_PATHWAY

EGFR LRP1 ITGB5

5.79e-0442553M174
PathwayKEGG_GNRH_SIGNALING_PATHWAY

EGFR PLA2G12A PLA2G2F PLA2G2C

6.40e-04101554M1979
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP3 ITGB5 FBN3

6.65e-0444553M26969
PathwayKEGG_MEDICUS_PATHOGEN_HSV_GD_TO_HVEM_NFKB_SIGNALING_PATHWAY

BIRC2 BIRC3

9.62e-0412552M47600
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

THBS1 RELN POLR3B ADAMTS9 ZNF423 LRP1 BIRC2 ZNF202 CACHD1 LTBP3 CMAS EDIL3 ZNF251 ZKSCAN5 SDHA

3.95e-081285711535914814
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

COL4A2 THBS1 RELN HMCN1 MEGF6 COL22A1 TNXB

7.34e-0817571728071719
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

COL4A2 THBS1 HMCN1 ADAMTS9 TNXB

2.13e-076471522261194
Pubmed

Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch.

EGFR BIRC2 BIRC3

2.84e-07771323972990
Pubmed

Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are increased after labour in foetal membranes and myometrium and are essential for TNF-α-induced expression of pro-labour mediators.

BIRC2 BIRC3

4.11e-06271225046208
Pubmed

Bradykinin B2 receptor activates extracellular signal-regulated protein kinase in mIMCD-3 cells via epidermal growth factor receptor transactivation.

EGFR BDKRB2

4.11e-06271212604671
Pubmed

Silencing of LAMC2 Reverses Epithelial-Mesenchymal Transition and Inhibits Angiogenesis in Cholangiocarcinoma via Inactivation of the Epidermal Growth Factor Receptor Signaling Pathway.

EGFR LAMC2

4.11e-06271231345467
Pubmed

Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans.

THBS1 LRP1

4.11e-06271214991768
Pubmed

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

BIRC2 BIRC3

4.11e-06271229452637
Pubmed

Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes.

BIRC2 BIRC3

4.11e-0627129441758
Pubmed

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy.

BIRC2 BIRC3

4.11e-06271231126323
Pubmed

Laminin-5γ-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration, and invasion by modulating signaling of EGFR.

EGFR LAMC2

4.11e-06271224170107
Pubmed

Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic Cholangiocarcinoma via Promoting EGFR Translation.

EGFR LAMC2

4.11e-06271238526177
Pubmed

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

BIRC2 BIRC3

4.11e-06271220651737
Pubmed

Cellular internalization and degradation of thrombospondin-1 is mediated by the amino-terminal heparin binding domain (HBD). High affinity interaction of dimeric HBD with the low density lipoprotein receptor-related protein.

THBS1 LRP1

4.11e-0627129045712
Pubmed

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.

BIRC2 BIRC3

4.11e-06271210797013
Pubmed

Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis.

ESRRB EDIL3

4.11e-06271217765677
Pubmed

Correlation between laminin-5 gamma2 chain and epidermal growth factor receptor expression in esophageal squamous cell carcinomas.

EGFR LAMC2

4.11e-06271216103736
Pubmed

Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1).

THBS1 LRP1

4.11e-06271217154366
Pubmed

Estrogen-related receptor β deficiency alters body composition and response to restraint stress.

ESRRB EDIL3

4.11e-06271224053666
Pubmed

Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.

THBS1 LRP1

4.11e-06271224877199
Pubmed

Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.

BIRC2 BIRC3

4.11e-06271223250032
Pubmed

Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression.

ESRRB EDIL3

4.11e-06271223360481
Pubmed

Self-termination of the terminator.

BIRC2 BIRC3

4.11e-06271219008929
Pubmed

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

BIRC2 BIRC3

4.11e-06271222434933
Pubmed

Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients.

BIRC2 BIRC3

4.11e-06271221795072
Pubmed

BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.

BIRC2 BIRC3

4.11e-06271234997070
Pubmed

Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.

BIRC2 BIRC3

4.11e-06271235985688
Pubmed

Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.

BIRC2 BIRC3

4.11e-0627129892732
Pubmed

Cellular inhibitors of apoptosis (cIAP) 1 and 2 are increased in placenta from obese pregnant women.

BIRC2 BIRC3

4.11e-06271225113061
Pubmed

Antigen-induced regulation of T-cell motility, interaction with antigen-presenting cells and activation through endogenous thrombospondin-1 and its receptors.

THBS1 LRP1

4.11e-06271225393517
Pubmed

c-IAP1 and c-IAP2 redundancy differs between T and B cells.

BIRC2 BIRC3

4.11e-06271223799077
Pubmed

The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival.

ESRRB EDIL3

4.11e-06271220534447
Pubmed

A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

BIRC2 BIRC3

4.11e-06271212651874
Pubmed

Subcellular expression of c-IAP1 and c-IAP2 in colorectal cancers: relationships with clinicopathological features and prognosis.

BIRC2 BIRC3

4.11e-06271214708638
Pubmed

Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia.

BIRC2 BIRC3

4.11e-06271215183896
Pubmed

Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate.

BIRC2 BIRC3

4.11e-06271220078866
Pubmed

Degradation of cIAPs contributes to hepatocyte lipoapoptosis.

BIRC2 BIRC3

4.11e-06271224008361
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

PRICKLE4 THBS1 EGFR ABCA12 LRP1 ITGB5

5.19e-0621471622199357
Pubmed

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.

BIRC2 BIRC3 EDIL3

5.43e-061771320080598
Pubmed

HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.

PLA2G12A PLA2G2F PLA2G2C

7.72e-06197139377118
Pubmed

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.

BIRC2 BIRC3

1.23e-05371221393245
Pubmed

Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.

BIRC2 BIRC3

1.23e-05371223184147
Pubmed

Clinicopathological significance of MMP-7, laminin γ2 and EGFR expression at the invasive front of gastric carcinoma.

EGFR LAMC2

1.23e-05371224048760
Pubmed

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

BIRC2 BIRC3

1.23e-05371219464198
Pubmed

Increased Expression of BIRC2, BIRC3, and BIRC5 from the IAP Family in Mesenchymal Stem Cells of the Umbilical Cord Wharton's Jelly (WJSC) in Younger Women Giving Birth Naturally.

BIRC2 BIRC3

1.23e-05371232322338
Pubmed

PERK-dependent regulation of IAP translation during ER stress.

BIRC2 BIRC3

1.23e-05371219029953
Pubmed

Gas1 is induced during and participates in excitotoxic neuronal death.

BIRC2 BIRC3

1.23e-05371211906213
Pubmed

To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

BIRC2 BIRC3

1.23e-05371220888210
Pubmed

Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas.

BIRC2 BIRC3

1.23e-05371216983704
Pubmed

Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.

BIRC2 BIRC3

1.23e-05371229518103
Pubmed

The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation.

BIRC2 BIRC3

1.23e-05371225065467
Pubmed

Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization.

BIRC2 BIRC3

1.23e-0537128938457
Pubmed

Identification of key proteins of cultured human intestinal cells involved in interaction with enteroaggregative Escherichia coli.

THBS1 EGFR

1.23e-05371222672426
Pubmed

Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

BIRC2 BIRC3

1.23e-05371221447281
Pubmed

Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.

THBS1 RELN

1.23e-05371238147128
Pubmed

Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation.

THBS1 EGFR

1.23e-05371221531776
Pubmed

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

PCSK5 LTBP3

1.23e-05371221700711
Pubmed

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

BIRC2 BIRC3

1.23e-05371221817100
Pubmed

MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.

BIRC2 BIRC3

1.23e-05371219276372
Pubmed

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

BIRC2 BIRC3

1.23e-05371214960576
Pubmed

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis.

THBS1 LRP1

1.23e-05371218653767
Pubmed

IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes.

LRP1 BIRC2

1.23e-05371216929535
Pubmed

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment.

BIRC2 BIRC3

1.23e-05371218784070
Pubmed

Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.

BIRC2 BIRC3

1.23e-05371212243753
Pubmed

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways.

EGFR BDKRB2

1.23e-05371226360782
Pubmed

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.

BIRC2 BIRC3

1.23e-05371215353805
Pubmed

GDC-0152 induces apoptosis through down-regulation of IAPs in human leukemia cells and inhibition of PI3K/Akt signaling pathway.

BIRC2 BIRC3

1.23e-05371225273171
Pubmed

cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression.

BIRC2 BIRC3

1.23e-05371223126497
Pubmed

Future Therapeutic Directions for Smac-Mimetics.

BIRC2 BIRC3

1.23e-05371232053868
Pubmed

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.

EGFR BIRC2

1.23e-05371229674627
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

COL4A2 THBS1 LTBP3 EDIL3 TNXB

1.27e-0514671527068509
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THBS1 LRP1 LTBP3 ZNF112

1.40e-057171433541421
Pubmed

Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.

PLA2G12A PLA2G2F PLA2G2C

2.05e-05267139745929
Pubmed

Transcriptome-based systematic identification of extracellular matrix proteins.

COL4A2 THBS1 LAMC2 EDIL3

2.13e-057971418757743
Pubmed

Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3.

BIRC2 BIRC3

2.46e-05471226612615
Pubmed

cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.

BIRC2 BIRC3

2.46e-05471219223549
Pubmed

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes.

BIRC2 BIRC3

2.46e-05471232028675
Pubmed

Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.

BIRC2 BIRC3

2.46e-05471229191979
Pubmed

Cell adhesion tunes inflammatory TPL2 kinase signal transduction.

BIRC2 BIRC3

2.46e-05471235218437
Pubmed

Hemicentin 1 influences podocyte dynamic changes in glomerular diseases.

HMCN1 EDIL3

2.46e-05471229488390
Pubmed

The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

BIRC2 BIRC3

2.46e-05471221849505
Pubmed

cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer.

EGFR BIRC3

2.46e-05471220959404
Pubmed

Variant mapping and mutation discovery in inbred mice using next-generation sequencing.

PCSK5 ABCA12

2.46e-05471226552429
Pubmed

Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.

BIRC2 BIRC3

2.46e-05471224194568
Pubmed

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.

BIRC2 BIRC3

2.46e-0547129545235
Pubmed

Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.

NOTCH2NLB NOTCH2

2.46e-05471232330268
Pubmed

Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein.

BIRC2 BIRC3

2.46e-05471210753917
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

THBS1 LRP1

2.46e-0547127775583
Pubmed

IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells.

BIRC2 BIRC3

2.46e-05471217069460
Pubmed

Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.

BIRC2 BIRC3

2.46e-05471222195745
Pubmed

Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1.

HMCN1 LAMC2

2.46e-05471215370542
Pubmed

The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination.

BIRC2 BIRC3

2.46e-05471216510124
Pubmed

Small-molecule SMAC mimetics as new cancer therapeutics.

BIRC2 BIRC3

2.46e-05471224841289
Pubmed

Apoptotic sensitivity of murine IAP-deficient cells.

BIRC2 BIRC3

2.46e-05471218684108
Pubmed

TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).

BIRC2 BIRC3

2.46e-05471221628460
Pubmed

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

BIRC2 BIRC3

2.46e-05471215665297
Pubmed

A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.

BIRC2 BIRC3

2.46e-05471224371121
Pubmed

CIAP2 inhibits anigen receptor signaling by targeting Bcl10 for degredation.

BIRC2 BIRC3

2.46e-05471216775419
Pubmed

Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.

BIRC2 BIRC3

2.46e-05471215798218
InteractionRIC8B interactions

EGFR LRP1 BIRC3 UPP1 VWA2

7.63e-0750695int:RIC8B
InteractionCACNA1A interactions

PCSK5 CACNB1 MEGF6 SCN5A LRP1 LTBP3

4.00e-06123696int:CACNA1A
Cytoband11q22

BIRC2 BIRC3

1.29e-041171211q22
Cytoband8q24.3

ZNF250 COL22A1 ZNF251

7.35e-041137138q24.3
CytobandEnsembl 112 genes in cytogenetic band chr5q14

ZCCHC9 BHMT2 EDIL3

1.25e-03136713chr5q14
Cytoband7q22

RELN ZKSCAN5

1.60e-03387127q22
CytobandEnsembl 112 genes in cytogenetic band chr1q25

PAPPA2 HMCN1 LAMC2

2.25e-03167713chr1q25
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF250 ZNF274 ZNF358 ZNF423 ZSCAN18 ZNF629 ZNF202 ZNF112 ZNF229 ZNF442 ZNF251 ZKSCAN5 ZNF286A

1.35e-07718541328
GeneFamilyRing finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing

BIRC2 BIRC3

2.42e-048542419
GeneFamilyPhospholipases

PLA2G12A PLA2G2F PLA2G2C

2.66e-0442543467
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SSC4D MEGF10

2.93e-03275421253
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

BIRC2 BIRC3

3.61e-0330542959
GeneFamilyCollagens

COL4A2 COL22A1

8.33e-0346542490
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

PAPPA2 BCAN

1.26e-02575421179
CoexpressionNABA_CORE_MATRISOME

COL4A2 THBS1 RELN HMCN1 LAMC2 BCAN LTBP3 COL22A1 EDIL3 VWA2 USH2A TNXB FBN3

3.92e-132757013M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 RELN HMCN1 LAMC2 LTBP3 EDIL3 VWA2 USH2A TNXB FBN3

1.17e-101967010M3008
CoexpressionNABA_MATRISOME

PAPPA2 COL4A2 PCSK5 THBS1 RELN HMCN1 MEGF6 ADAMTS9 LAMC2 BCAN LTBP3 COL22A1 EDIL3 VWA2 USH2A TNXB FBN3 MEGF10

1.36e-1010267018M5889
CoexpressionNABA_CORE_MATRISOME

COL4A2 THBS1 RELN HMCN1 LAMC2 BCAN LTBP3 COL22A1 EDIL3 VWA2 TNXB

1.43e-102707011MM17057
CoexpressionNABA_MATRISOME

PAPPA2 COL4A2 PCSK5 THBS1 RELN HMCN1 MEGF6 ADAMTS9 LAMC2 BCAN LTBP3 COL22A1 EDIL3 VWA2 TNXB MEGF10

7.17e-0910087016MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 RELN HMCN1 LAMC2 LTBP3 EDIL3 VWA2 TNXB

4.40e-08191708MM17059
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

COL4A2 THBS1 LRP1 LAMC2 EDIL3 ITGB5 NOTCH2

1.08e-06200707M5930
CoexpressionNABA_BASEMENT_MEMBRANES

COL4A2 HMCN1 LAMC2 USH2A

3.96e-0640704M5887
CoexpressionPHONG_TNF_TARGETS_UP

ADAMTS9 BIRC2 BIRC3 LAMC2

2.47e-0563704M2496
CoexpressionHEBERT_MATRISOME_TNBC_LUNG_METASTASIS

COL4A2 LAMC2 TNXB

3.11e-0523703M48001
CoexpressionBLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_INFECTION_UP

THBS1 EGFR HELZ2 BIRC3 EDIL3

3.34e-05137705M34024
CoexpressionLU_EZH2_TARGETS_DN

ZCCHC9 THBS1 EGFR BIRC2 FAM83D LAMC2 CACHD1

9.59e-05400707M2140
CoexpressionSNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS

EGFR BIRC2 BIRC3

1.33e-0437703M12802
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 THBS1 EGFR LRP1 LTBP3 COL22A1 EDIL3 ITGB5

9.45e-10196718fcb275746bf51269ed8ba4cf93edb054a45f1ccd
ToppCell(2)_Fibroblasts-(21)_Fibro-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

EGFR LRP1 LTBP3 COL22A1 TNXB ITGB5 MEGF10

2.35e-081917175ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 THBS1 EGFR LRP1 LTBP3 TNXB ITGB5

2.53e-0819371749600db68ed65cafc67bd45a285b364e4f5f88af
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 THBS1 EGFR LRP1 LTBP3 TNXB ITGB5

2.53e-0819371745b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN HMCN1 ABCA12 TENM1 COL22A1 USH2A

4.95e-071847162cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN HMCN1 ABCA12 TENM1 COL22A1 USH2A

4.95e-07184716ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN HMCN1 ABCA12 TENM1 COL22A1 USH2A

4.95e-071847162b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A2 THBS1 EGFR TENM1 LRP1 TNXB

5.11e-071857169faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNB1 THBS1 SCN5A LRP1 CACHD1 EDIL3

5.28e-07186716f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 LRP1 LTBP3 COL22A1 EDIL3 ITGB5

6.35e-07192716b35f0e422070ba9c7c1d9ff3eace4edc10286cde
ToppCellfacs-Heart-RA-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EGFR LRP1 LTBP3 TNXB ITGB5 NOTCH2

6.75e-07194716bc945450b350f597c3ff910d3a14a533d90086a8
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 EGFR LRP1 CACHD1 LTBP3 ITGB5

7.16e-07196716b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 EGFR LRP1 CACHD1 LTBP3 ITGB5

7.16e-07196716787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 EGFR LRP1 LTBP3 TNXB ITGB5

7.60e-071987160dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 THBS1 LRP1 LTBP3 COL22A1 ITGB5

7.83e-07199716edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN FAM83D CACHD1 RXFP1 MEGF10

1.46e-061217157f2057367777c6c92f596054cbc5fe567d079fbc
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Nptx2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN CACHD1 RXFP1 ITGB5 MEGF10

1.52e-0612271591e338db581b36baffecc323b1909f2069b27242
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN MEGF6 EGFR FAM83D RXFP1

3.93e-061487155e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCell21-Trachea-Epithelial-Submucosal_gland_basal|Trachea / Age, Tissue, Lineage and Cell class

COL4A2 HMCN1 ADAMTS9 BCAN COL22A1

5.58e-061597154f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BUD23 ZNF250 VWA2 TNXB ZNF286A

6.11e-0616271556f1789e69a6cb29956e46aba92b290847327c1f
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)-|356C / Donor, Lineage, Cell class and subclass (all cells)

RELN ADAMTS9 SCN5A BHMT2 TNXB

6.88e-061667155ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)|356C / Donor, Lineage, Cell class and subclass (all cells)

RELN ADAMTS9 SCN5A BHMT2 TNXB

6.88e-061667156bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ABCA12 TENM1 CACHD1 BDKRB2

8.41e-061737152e35bf2b5534a289d93a09faae660f665c131062
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 ADAMTS9 UPP1 VWA2 BDKRB2

8.65e-0617471540bb87d219aafab0357ab0d797efd38085fc0312
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DPF1 COL4A2 THBS1 EGFR NOTCH2

8.89e-06175715910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DPF1 COL4A2 THBS1 EGFR NOTCH2

8.89e-06175715f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

RELN ADAMTS9 ZNF423 BHMT2 TNXB

9.66e-06178715c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN ADAMTS9 BIRC3 LAMC2 ZNF286A

9.92e-06179715dfd5b25f2a6a5a8bf4714f1516cb0997de72b06f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 TENM1 BIRC3 RXFP1 VWA2

1.02e-05180715b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 HMCN1 ESRRB LAMC2 UPP1

1.08e-05182715a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A2 THBS1 ADAMTS9 ZSCAN18 COL22A1

1.08e-05182715ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 RELN ADAMTS9 TENM1 ITGB5

1.13e-051847157f6c8912677764d438ab0555faca344d74c2f483
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

PAPPA2 PCSK5 THBS1 HMCN1 MEGF10

1.16e-05185715427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellEndothelial-B-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 RELN ADAMTS9 BHMT2 TNXB

1.16e-05185715133c9dc64d564dae4aeeeca22f386aa3f13fa980
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 RELN ADAMTS9 TENM1 ITGB5

1.19e-0518671596f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCellAnterior_Cingulate_gyrus_(CgG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 ADAMTS9 TENM1 BIRC3 CACHD1

1.19e-0518671532af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A2 THBS1 EGFR LRP1 TNXB

1.19e-051867157582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 RELN ADAMTS9 TENM1 ITGB5

1.23e-0518771585f1678338a47d91e296f0620d4887f057eb7e70
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

COL4A2 PCSK5 EGFR LRP1 TNXB

1.23e-051877154ea486991f66c29728d127171a07b81404ec0b78
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 THBS1 RELN EDIL3 CRB2

1.26e-05188715b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A2 THBS1 EGFR ITGB5 NOTCH2

1.26e-051887154544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 THBS1 RELN EDIL3 CRB2

1.26e-05188715874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellTransplant_Alveoli_and_parenchyma-Endothelial-Lymphatic|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

COL4A2 RELN ADAMTS9 BHMT2 TNXB

1.32e-051907158d6ec2fc0af19a5cb16fff34f8b131b71b33d45f
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel|Adult / Lineage, Cell type, age group and donor

RELN ADAMTS9 ZNF423 BHMT2 TNXB

1.32e-0519071591bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.32e-05190715c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.32e-05190715834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPF1 PAPPA2 PCSK5 LTBP3 ZNF286A

1.36e-051917159d3fa8d8138700640cc7927521c7635299df697d
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPF1 PAPPA2 PCSK5 THBS1 MEGF10

1.36e-05191715fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPF1 PAPPA2 PCSK5 LTBP3 ZNF286A

1.36e-05191715d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 EGFR LRP1 EDIL3 TNXB

1.39e-0519271511088878043a6ff95ba1970361256a82e434b80a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 EGFR LRP1 TNXB ITGB5

1.39e-05192715beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPF1 PAPPA2 PCSK5 LTBP3 ZNF286A

1.43e-051937152b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EGFR LRP1 LTBP3 TNXB ITGB5

1.43e-05193715d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellcritical-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

COL4A2 ADAMTS9 BCAN COL22A1 MEGF10

1.43e-051937156be11fef87af04ee7a3cc223882ccd4077caded9
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPF1 PAPPA2 PCSK5 LTBP3 ZNF286A

1.43e-0519371590cfc34c2d0d7c70f071703d35db1d6037961481
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1 COL22A1 TNXB ITGB5 BDKRB2

1.46e-0519471569362e13158033de44f90f3773db6c0f27de8cb3
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

THBS1 EGFR LRP1 TNXB NOTCH2

1.46e-05194715d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A2 HMCN1 ZNF423 CACHD1 RXFP1

1.46e-051947150b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellP28-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.46e-051947153c661c6768c3f05d2aba03d329adb257ca201b2d
ToppCellAdult-Endothelial|Adult / Lineage, Cell type, age group and donor

COL4A2 RELN ADAMTS9 ZNF423 RXFP1

1.46e-05194715963b3fbee0575af8379baa397ace65949eaf34f7
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

COL4A2 PCSK5 EGFR LRP1 TNXB

1.46e-05194715234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.50e-05195715d32716a12014522492becbde1088dc1106308490
ToppCellfacs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 LTBP3 TNXB ITGB5 NOTCH2

1.50e-05195715690d6e15d7c863fc8f2d33b1f7bf86f019f415c9
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

COL4A2 PCSK5 EGFR LRP1 TNXB

1.50e-05195715a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.50e-05195715c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.50e-051957153f64e2313ec79a6d5f4013a52722d071172f6c5d
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.50e-05195715b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.50e-05195715ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCellfacs-Lung-3m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THBS1 EGFR LTBP3 ITGB5 NOTCH2

1.50e-05195715c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
ToppCellfacs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 LTBP3 TNXB ITGB5 NOTCH2

1.50e-051957155c05e2bcea3d5d7ebe6325f7187ccf83301053d8
ToppCellASK452|World / Donor, Lineage and Cell class of Lung cells from Dropseq

THBS1 ADAMTS9 BIRC3 LAMC2 EDIL3

1.50e-051957157efd9d3a3f5e7dfe9698a4143ce4a0f9bf3a862c
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.50e-051957157a5108335353ac160b684650c5da97d6f7f4dbcf
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 PCSK5 HMCN1 EGFR LRP1

1.54e-051967156bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 THBS1 RELN EDIL3 CRB2

1.54e-0519671534e79918a448f6c19b87e1b1ce13c012b24be1f8
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 PCSK5 HMCN1 EGFR LRP1

1.54e-05196715c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 THBS1 RELN EDIL3 CRB2

1.54e-051967158f82e01ca50aa4cd6149547505b4474a02fad618
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 HMCN1 LRP1 RXFP1 TNXB

1.54e-05196715fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 HMCN1 LRP1 RXFP1 TNXB

1.54e-05196715802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 THBS1 RELN EDIL3 CRB2

1.54e-05196715545d2e4469924d333e3f655f559c899fa1260196
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.58e-051977157d97c2d51a543c02d679e9257b22d0581e73a11d
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG|World / Primary Cells by Cluster

BCAN ITGB5 MEGF10 NOTCH2 CRB2

1.58e-0519771561749ccafeb938c310cff1de5ff924a1c794325a
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 BHMT2 LRP1 TNXB ITGB5

1.58e-0519771571786e9432e2d649f5d86f639abb25e7102deb67
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 PCSK5 THBS1 LTBP3 MEGF10

1.58e-05197715671d6b5effbac2dd71d18f48d23c523738db1828
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HMCN1 BHMT2 TENM1 BCAN TNXB

1.58e-0519771544673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG-25|World / Primary Cells by Cluster

BCAN ITGB5 MEGF10 NOTCH2 CRB2

1.58e-051977159d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCellBronchus_Control_(B.)-Stromal-TX-Smooth_muscle-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

COL4A2 ADAMTS9 SCN5A EDIL3 EDA2R

1.61e-051987150f1feed8a37293ae02465909f99548ab58dc7ce5
ToppCellFibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

COL4A2 EGFR LRP1 LTBP3 ITGB5

1.65e-0519971540de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 THBS1 RELN EDIL3 CRB2

1.65e-05199715b9338b739162cd8e5661c9a4dcb41a31219b5723
ToppCell(02)_MMP9/10+-(1)_GFP|(02)_MMP9/10+ / shred by cell type by condition

COL4A2 THBS1 LAMC2 UPP1 COL22A1

1.65e-05199715448ba982be804007f991d469eca9d885b21ae499
ToppCell(03)_KRT6B+|World / shred by cell type by condition

COL4A2 THBS1 BIRC3 LAMC2 COL22A1

1.65e-051997159feaf8649b3f68f30b8cb6b045a2caa2dd343c7f
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-3|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

COL4A2 EDIL3 TNXB EDA2R MEGF10

1.65e-0519971507b8c33342c62afd9c63ec2d757cfa3ba65d2a98
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 THBS1 RELN EDIL3 CRB2

1.65e-05199715c972d3036151403f26fa9d6271520639c281ab84
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 COL4A2 THBS1 LAMC2 UPP1

1.69e-05200715ae91dc047dc80560ba298d8d21a772154fa2775d
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 THBS1 LRP1 LTBP3 TNXB

1.69e-052007159d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 THBS1 LRP1 LTBP3 TNXB

1.69e-05200715a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A2 HMCN1 TENM1 LRP1 TNXB

1.69e-05200715b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial-Astrocyte|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NOTCH2NLB BCAN ITGB5 MEGF10 NOTCH2

1.69e-052007157c66953ff6d8f16f4decd23c85232990d2d8c6c4
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-erythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB1 WDR25 CMAS ZKSCAN5

1.99e-05100714f305bc37f97617007b59bf06d288dd14c3c06e42
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Nptx2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN RXFP1 ITGB5 MEGF10

4.34e-051227141720756e0b3e8db14a9ccabe83f9b41689a4f754
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Tmem182|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN FAM83D CACHD1 RXFP1

4.63e-05124714690595d710b57b7cff8029a3bb06a8dd7e3c03c1
Druggamma-secretase inhibitor I

BIRC2 BIRC3 NOTCH2

1.11e-074703CID011754711
Drugpyrachlostrobin

THBS1 EGFR ADAMTS9 SCN5A FAM83D LTBP3 COL22A1 ITGB5 BDKRB2 EDA2R MEGF10 NOTCH2 CRB2

9.81e-078117013ctd:C513428
DrugFlurandrenolide [1524-88-5]; Up 200; 9.2uM; HL60; HT_HG-U133A

PAPPA2 THBS1 MEGF6 ZSCAN18 UPP1 WDR25

1.88e-051797062184_UP
DrugAkt-I-1 compound

BIRC2 BIRC3

2.79e-053702ctd:C501520
Drugaclacinomycins

BIRC2 BIRC3

2.79e-053702ctd:C011157
DrugBenfotiamine [22457-89-2]; Up 200; 8.6uM; HL60; HT_HG-U133A

THBS1 ZSCAN18 BIRC3 LTBP3 WDR25 ITGB5

3.22e-051977062177_UP
DrugSisomicin sulfate [53179-09-2]; Up 200; 2.8uM; PC3; HT_HG-U133A

PAPPA2 CACNB1 AAAS MEGF6 BHMT2 TENM1

3.22e-051977064014_UP
DrugPC9

EGFR BIRC2 BIRC3 UPP1

3.28e-0559704CID016040245
DrugSTOCK1N-28457; Up 200; 20uM; MCF7; HT_HG-U133A

PAPPA2 ABCA12 ZNF423 LAMC2 ZKSCAN5 NOTCH2

3.40e-051997066869_UP
DrugLabetalol hydrochloride [32780-64-6]; Up 200; 11uM; MCF7; HT_HG-U133A

DPF1 PCSK5 CACNB1 MEGF6 ADAMTS9 TENM1

3.50e-052007063167_UP
Diseasecentral nervous system cancer

PAPPA2 POLR3B EGFR

5.25e-0531693EFO_0000326
Diseasepulse pressure measurement, migraine without aura, susceptibility to, 4

LRP1 ITGB5

1.92e-049692EFO_0005763, MONDO_0011847
Diseaseglioblastoma multiforme

POLR3B EGFR

1.92e-049692EFO_0000519
DiseaseCardiomyopathy, Dilated

EGFR SCN5A SDHA

1.96e-0448693C0007193
Diseaseage at onset, multiple sclerosis

PCSK5 RELN

2.40e-0410692EFO_0004847, MONDO_0005301
Diseasecortical thickness

COL4A2 THBS1 RELN EGFR ADAMTS9 ZNF423 LRP1 CMAS ITGB5 CRB2

2.52e-0411136910EFO_0004840
Diseasecortical surface area measurement

THBS1 RELN MEGF6 EGFR ADAMTS9 ZNF423 CACHD1 COL22A1 TNXB ITGB5 FBN3

2.71e-0413456911EFO_0010736
DiseaseSmall cell carcinoma of lung

COL4A2 EGFR COL22A1

2.79e-0454693C0149925
DiseaseAmelogenesis Imperfecta

LAMC2 LTBP3

3.50e-0412692C0002452
Diseaseresponse to antipsychotic drug

ZNF202 COL22A1 MEGF10

3.81e-0460693GO_0097332
Diseaseoral squamous cell carcinoma (is_marker_for)

EGFR BIRC2 BIRC3

4.40e-0463693DOID:0050866 (is_marker_for)
Diseasecolorectal cancer (is_marker_for)

THBS1 EGFR BIRC2 BIRC3

5.10e-04157694DOID:9256 (is_marker_for)
Diseasehigh grade glioma (biomarker_via_orthology)

BCAN BDKRB2

5.55e-0415692DOID:3070 (biomarker_via_orthology)
Diseasecardiomyopathy (implicated_via_orthology)

EGFR LRP1 SDHA

6.24e-0471693DOID:0050700 (implicated_via_orthology)
Diseaselung non-small cell carcinoma (is_marker_for)

EGFR BIRC2 BIRC3 LAMC2

6.72e-04169694DOID:3908 (is_marker_for)
DiseaseQRS duration

HMCN1 ZNF358 SCN5A MEGF10 NOTCH2

6.73e-04298695EFO_0005055
Diseaseotosclerosis

COL4A2 RELN LTBP3

9.16e-0481693EFO_0004213
DiseaseColorectal Carcinoma

CACNB1 EGFR ABCA12 TENM1 LRP1 ZNF442 VWA2

1.26e-03702697C0009402
DiseaseDegenerative polyarthritis

LTBP3 EDIL3 SDHA

1.37e-0393693C0029408
DiseaseOsteoarthrosis Deformans

LTBP3 EDIL3 SDHA

1.37e-0393693C0086743
DiseaseSquamous cell carcinoma of esophagus

EGFR TNXB NOTCH2

1.45e-0395693C0279626
Diseaseresponse to interferon

COL22A1 CMAS

1.56e-0325692EFO_0007859
Diseasesciatic neuropathy (biomarker_via_orthology)

PCSK5 LRP1 BDKRB2

1.63e-0399693DOID:11446 (biomarker_via_orthology)
Diseasemigraine disorder, pulse pressure measurement

LRP1 ITGB5

1.69e-0326692EFO_0005763, MONDO_0005277
Diseaseretinitis pigmentosa (implicated_via_orthology)

USH2A CRB2

1.82e-0327692DOID:10584 (implicated_via_orthology)
DiseaseFEV/FEC ratio

COL4A2 PCSK5 HMCN1 MEGF6 LRP1 LAMC2 LTBP3 TNXB CRB2

2.18e-031228699EFO_0004713
DiseasePrimary familial dilated cardiomyopathy

SCN5A SDHA

2.25e-0330692cv:C0340427

Protein segments in the cluster

PeptideGeneStartEntry
VGERPYECNECGKGF

ZNF286A

321

Q9HBT8
ENKPCYLLDIGCGTG

BUD23

51

O43709
VYQGVCQKGGCRSEP

BDKRB2

346

P30411
LSFPERCGEGKGCVG

AAAS

356

Q9NRG9
GRNKARYCAEGGGPV

CACNB1

566

Q02641
RYCAEGGGPVLGRNK

CACNB1

571

Q02641
EQGGLRCCGSPFYLK

ABCA12

1551

Q86UK0
GTVIPNGYCDFCLGG

DPF1

266

Q92782
YCAPQKECFGGIVGA

CACHD1

1056

Q5VU97
DCSGGCQCYPEKGGR

COL4A2

46

P08572
YIGPGDRVACFACGG

BIRC3

196

Q13489
CTRGYKLSPGGACVG

FBN3

1791

Q75N90
GYGCYCGLGDKGIPV

PLA2G2C

41

Q5R387
RGEKCELPCQDGTYG

MEGF10

521

Q96KG7
EGVRCLCLPGYGGDL

BCAN

666

Q96GW7
LCLPGYGGDLCDVGL

BCAN

671

Q96GW7
NGTGYCKCPEGFLGE

NOTCH2NLB

46

P0DPK3
NGTGYCKCPEGFLGE

NOTCH2

46

Q04721
LGGEDGLCQYKCSDG

PLA2G12A

56

Q9BZM1
VCAPGYGGTRCQLDL

CRB2

171

Q5IJ48
GGQLGCLLDPNGEKC

IBTK

311

Q9P2D0
DQYGKPGGCSDICLL

LRP1

481

Q07954
LLGGSCVRKCGPGFY

PCSK5

1106

Q92824
GEGGPYGCKDALRQQ

FAM83D

141

Q9H4H8
KGRLCGDGTGACYLL

FAM169B

61

Q8N8A8
CYCGLGGRGQPKDEV

PLA2G2F

46

Q9BZM2
CQDGVSYPGQRKCEG

ITGB5

401

P18084
PGYLGTRCECQDGEN

ITGB5

491

P18084
EGCYPASAGKGCEGN

RELN

1336

P78509
GCSDPVPQYGGRKCE

HMCN1

4726

Q96RW7
CQDCAGPLGGGRYAL

PRICKLE4

176

Q2TBC4
GAPYCGDGKVSERLG

PAPPA2

1111

Q9BXP8
GRNCQYKCSGPLGIE

EDIL3

151

O43854
GPCRKVCNGIGIGEF

EGFR

331

P00533
PDGTRVVGKCGGYCG

ADAMTS9

1906

Q9P2N4
NLGVRYIGGCCGFEP

BHMT2

281

Q9H2M3
CALGGQCVKGDRGAP

COL22A1

1016

Q8NFW1
KCIACQPGYRSQGGG

LTBP3

726

Q9NS15
PGVTGARCELCADGY

LAMC2

486

Q13753
GLGGTPCRKSYEDCA

ESRRB

66

O95718
RGEKRLGGPCILYCG

HELZ2

2206

Q9BYK8
AVYSLEPRLCGGKGG

SDE2

66

Q6IQ49
SGECGKRCPAGFQGE

MEGF6

711

O75095
CVGAELGLDCPGRDY

UPP1

71

Q16831
CCGGEEGVVYNRLPG

USH2A

3306

O75445
YGAGCLITEGCRGEG

SDHA

301

P31040
VGYICKCNGGRGAIR

CMAS

401

Q8NFW8
DAGTCPEGYRCLKAG

SCN5A

331

Q14524
DSCPVLCGGNGEYEK

TENM1

561

Q9UKZ4
GAGKPVRYLCEGAGD

RFXAP

66

O00287
YIGPGDRVACFACGG

BIRC2

211

Q13490
CECKPGYAGNGIICG

THBS1

676

P07996
GEKPYECGECGRAFN

ZNF250

531

P15622
VGGAKYLPGCCNRVL

RHD

306

Q02161
YGRGPVLLDNVGCAG

SSC4D

401

Q8WTU2
GERPYVCQDCGKGFV

ZNF274

531

Q96GC6
ENGRCVCNPGYTGED

TNXB

291

P22105
NGGTCVPEGLDGYQC

VWA2

306

Q5GFL6
GGQDVKCSLGYFPCG

RXFP1

21

Q9HBX9
EVDVCGQCGLLGYSG

POLR3B

1076

Q9NW08
GERPYVCDVCGKGFI

ZNF229

596

Q9UJW7
IVQRGGGPYICKLCG

ZNF442

201

Q9H7R0
SGERPYICEVCGKGF

ZNF112

716

Q9UJU3
GEKPYVCNECGRAFG

ZNF251

401

Q9BRH9
GLSRGKPYACGECGE

ZSCAN18

406

Q8TBC5
LYADGGGCKLCGSVE

ZCCHC9

206

Q8N567
KLDVNGLPYGLCAGC

ZNF423

1081

Q2M1K9
KVEGYSVGCECSPGG

WDR25

471

Q64LD2
GRPAGAEKPYICNEC

ZNF629

141

Q9UEG4
CGPGQELSKDCGYGE

EDA2R

21

Q9HAV5
GRCVICGGPGVSDAY

PHF5A

56

Q7RTV0
HLGGKPYLCGECGED

ZNF202

531

O95125
EGYICPVLFGSACGG

TMEM38A

241

Q9H6F2
GERPYGCNECGKNFG

ZKSCAN5

426

Q9Y2L8
GERPYRCQLCGKAFG

ZNF358

371

Q9NW07