Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	1.23e-12	1244	42	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	1.80e-12	1271	42	19	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 SP7 ZNF189	1.14e-11	1412	42	19	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	2.02e-11	1459	42	19	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF600 ZNF841 ZNF226 ZNF519 ZNF606 SP7	1.05e-03	560	42	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF600 ZNF841 ZNF226 ZNF519 ZNF606 SP7	1.11e-03	566	42	6	GO:0001216
Domain	-	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	1.63e-18	679	41	20	3.30.160.60
Domain	zf-C2H2	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	2.42e-18	693	41	20	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	2.49e-18	694	41	20	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	2.13e-17	775	41	20	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	2.24e-17	777	41	20	PS00028
Domain	Znf_C2H2-like	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	3.58e-17	796	41	20	IPR015880
Domain	Znf_C2H2	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	4.45e-17	805	41	20	IPR007087
Domain	ZnF_C2H2	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	4.78e-17	808	41	20	SM00355
Domain	zf-C2H2_6	ZNF787 ZNF737 ZNF677 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF606 ZNF157 ZNF160	5.14e-11	314	41	11	PF13912
Domain	KRAB	ZNF737 ZNF677 ZNF773 ZNF84 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF189	2.08e-10	358	41	11	PS50805
Domain	KRAB	ZNF737 ZNF677 ZNF773 ZNF84 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF189	2.08e-10	358	41	11	PF01352
Domain	KRAB	ZNF737 ZNF677 ZNF773 ZNF84 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF189	2.87e-10	369	41	11	SM00349
Domain	KRAB	ZNF737 ZNF677 ZNF773 ZNF84 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF189	2.95e-10	370	41	11	IPR001909
Domain	Sp1_fam	SP5 SP9 SP8 SP7	4.16e-09	10	41	4	IPR030450
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF737 ZNF677 ZNF600 ZNF773 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 FURIN SP7 ZNF189	4.44e-06	1387	32	13	M734
Pubmed	Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning.	SP5 SP9 SP8 SP7	2.54e-10	9	43	4	17509151
Pubmed	Mammalian SP/KLF transcription factors: bring in the family.	SP5 SP9 SP8 SP7	2.51e-08	25	43	4	15820306
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF737 ZNF84 ZNF841 ZNF486 ZNF160	2.96e-06	181	43	5	37372979
Pubmed	Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.	SP9 SP8	1.49e-05	5	43	2	15358670
Pubmed	Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.	SP5 SP8	4.16e-05	8	43	2	26969725
Pubmed	Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells.	SP5 SP8	9.78e-05	12	43	2	24475213
Pubmed	Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons.	SP9 SP8	1.15e-04	13	43	2	34014554
Pubmed	Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration.	SP9 SP8	1.15e-04	13	43	2	31001083
Pubmed	Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.	SP9 SP8	1.15e-04	13	43	2	31070778
Pubmed	Replication of recently described type 2 diabetes gene variants in a South Indian population.	MC4R WFS1	1.15e-04	13	43	2	20580033
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	JCAD ZNF84 PTPN13 ZNF841 REPS1 ZNF606 GFPT1 ZNF189	1.56e-04	1285	43	8	35914814
Pubmed	The transcription factor Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity.	SP9 SP8	2.01e-04	17	43	2	36081908
Pubmed	Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.	SP9 SP8	2.01e-04	17	43	2	17376983
Pubmed	Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.	MC4R FARS2	2.52e-04	19	43	2	23563609
Pubmed	A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation.	SP5 SP8	2.52e-04	19	43	2	32156757
Pubmed	Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.	SP9 SP8	2.52e-04	19	43	2	28981617
Pubmed	Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.	SP9 SP8	2.52e-04	19	43	2	32234482
Pubmed	Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.	MC4R WFS1	3.40e-04	22	43	2	19794065
Pubmed	Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.	SP9 SP8	4.05e-04	24	43	2	29878134
Pubmed	Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.	SP9 SP8	4.40e-04	25	43	2	23042297
Pubmed	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.	SP8 WFS1	5.14e-04	27	43	2	37995181
Pubmed	Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.	ZNF486 PNKD TRIM41 SOCS5	5.47e-04	305	43	4	21244100
Pubmed	The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.	SP9 SP8	5.53e-04	28	43	2	32868762
Pubmed	Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.	SP9 SP8	5.53e-04	28	43	2	30796806
Pubmed	SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.	SP9 SP8	5.53e-04	28	43	2	29967281
Pubmed	Obesity and diabetes genetic variants associated with gestational weight gain.	MC4R WFS1	5.93e-04	29	43	2	20816152
Pubmed	Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain.	SP9 SP8	6.35e-04	30	43	2	17470284
Pubmed	Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos.	SP5 SP8	6.35e-04	30	43	2	31789450
Pubmed	Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.	SP9 SP8	7.23e-04	32	43	2	35156680
Pubmed	Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.	SP5 SP8	7.69e-04	33	43	2	18480165
Pubmed	A census of human transcription factors: function, expression and evolution.	SP5 SP9 ZNF444 ZNF157 ZNF160 SP7	8.33e-04	908	43	6	19274049
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	LINC00299 JCAD ZNF444 ARHGAP45 GFPT1	1.11e-03	638	43	5	31182584
Interaction	SP9 interactions	SP9 SP7	4.24e-06	2	42	2	int:SP9
Interaction	ZNF519 interactions	SP8 ZNF519	4.24e-06	2	42	2	int:ZNF519
Interaction	SP8 interactions	SP8 ZNF519	2.54e-05	4	42	2	int:SP8
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF787 ZNF677 ZNF444 ZNF600 ZNF773 ZNF841 ZNF226 ZNF606 ZNF160 ZNF835	1.18e-07	1192	43	10	chr19q13
Cytoband	19q13.43	ZNF787 ZNF444 ZNF773 ZNF835	1.40e-06	87	43	4	19q13.43
Cytoband	19q13.41	ZNF600 ZNF841	2.46e-03	78	43	2	19q13.41
Cytoband	2q31.1	SP5 SP9	2.85e-03	84	43	2	2q31.1
Cytoband	19p12	ZNF737 ZNF486	3.26e-03	90	43	2	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF737 ZNF486	5.89e-03	122	43	2	chr19p12
Cytoband	19q13.42	ZNF677 ZNF160	6.17e-03	125	43	2	19q13.42
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF787 ZNF737 SP5 SP9 SP8 ZNF677 ZNF444 ZNF600 ZNF773 ZNF84 ZNF841 ZNF486 ZNF226 ZNF519 ZNF606 ZNF157 ZNF160 ZNF835 SP7 ZNF189	1.06e-20	718	32	20	28
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP5 SP9 SP8 SP7	1.01e-09	9	32	4	755
ToppCell	Control-Epithelial-Ionocyte\|Epithelial / Disease state, Lineage and Cell class	SP8 ZNF677 ZNF773 ZNF519 SP7	3.94e-07	155	43	5	4b9369b203a4d7071c56d3d8e6b450e9a0121c41
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LINC00299 ZNF486 ZNF157 METRNL	2.02e-05	167	43	4	e242827999caad08b0894d88ab97bc1df41b7650
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	LINC00299 FAM120B ZNF486 METRNL	2.71e-05	180	43	4	310a311c3ed924c912a800cf287a825de44b8775
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD ZNF606 WFS1 TRIM41	2.71e-05	180	43	4	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LINC00299 ZNF600 TRIM41 FURIN	2.89e-05	183	43	4	f079179f2984def91ddf0b33d7949d5ecdbd380d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LINC00299 ZNF600 TRIM41 FURIN	2.89e-05	183	43	4	49e8ee16e4f677f9f649e2a2faf1b9b16c5a27e7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINC00299 SP9 SP8 SP7	3.01e-05	185	43	4	6e7fefdd65d30abaffb26b92b0d04e1630d262ad
ToppCell	VE-NK\|VE / Condition, Cell_class and T cell subcluster	ZNF600 FUT7 METRNL FURIN	3.85e-05	197	43	4	cae6ff8763501e7a5897b50188ac2640d65a47c0
ToppCell	VE-NK-\|VE / Condition, Cell_class and T cell subcluster	ZNF600 FUT7 METRNL FURIN	3.85e-05	197	43	4	ee89b8521fb4faaed9e4d39f7171e45eccf38b00
Disease	factor XI measurement, coronary artery disease	JCAD ZNF160 KNG1 FURIN	1.98e-05	115	41	4	EFO_0001645, EFO_0004694
Disease	factor XI measurement	ZNF160 KNG1	5.25e-05	8	41	2	EFO_0004694
Disease	factor XI measurement, Ischemic stroke	ZNF160 KNG1	2.53e-04	17	41	2	EFO_0004694, HP_0002140
Disease	partial thromboplastin time	ZNF160 KNG1	5.10e-04	24	41	2	EFO_0004310
Disease	factor VIII measurement, coronary artery disease	JCAD ACAD10 FURIN	5.24e-04	113	41	3	EFO_0001645, EFO_0004630
Disease	antipsychotic drug related weight gain	MC4R LINC00299	6.47e-04	27	41	2	EFO_0004567
Disease	factor XI measurement, venous thromboembolism	ZNF160 KNG1	7.99e-04	30	41	2	EFO_0004286, EFO_0004694
Disease	diastolic blood pressure, unipolar depression	ACAD10 FURIN	7.99e-04	30	41	2	EFO_0003761, EFO_0006336
Disease	factor VIII measurement, venous thromboembolism	ZNF160 KNG1	1.03e-03	34	41	2	EFO_0004286, EFO_0004630
Disease	chronic kidney disease, diabetic nephropathy	PTPN13 REPS1	1.15e-03	36	41	2	EFO_0000401, EFO_0003884
Disease	coronary artery disease	MC4R ZNF787 JCAD SP8 ACAD10 REPS1 FURIN	1.18e-03	1194	41	7	EFO_0001645
Disease	HbA1c measurement	LINC00299 PNKD ARHGAP45 WFS1 METRNL	2.34e-03	675	41	5	EFO_0004541
Disease	diastolic blood pressure, alcohol consumption measurement	ACAD10 FURIN	2.58e-03	54	41	2	EFO_0006336, EFO_0007878
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	ZNF160 KNG1	2.77e-03	56	41	2	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	Insulin Sensitivity	MC4R METRNL	3.17e-03	60	41	2	C0920563
Disease	Insulin Resistance	MC4R METRNL	3.17e-03	60	41	2	C0021655
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	JCAD FURIN	3.49e-03	63	41	2	EFO_0001645, EFO_0004792
Disease	lymphocyte count	LINC00299 JCAD ACAD10 TMEM267 FUT7 ARHGAP45 NUP88	3.73e-03	1464	41	7	EFO_0004587

Protein segments in the cluster

Peptide	Gene	Start	Entry
HHERWKREGKLHNHG	nan	301	A8MVM7
LHRHGDQAWGKHRRQ	LINC00299	56	Q6ZSB3
LKHTQRRHQGSHRWT	ACAD10	21	Q6JQN1
RRHQGSHRWTHLGGS	ACAD10	26	Q6JQN1
RISSGKAGTHWHQVR	DET1	26	Q7L5Y6
KDHRAGRGHQVHKSW	ARHGAP45	606	Q92619
KHRELKHSGSWPGHR	JCAD	671	Q9P266
HTHGLSHLRGIFNWV	FUT7	126	Q11130
RCSWKGSGLTHEAHR	METRNL	51	Q641Q3
HFWHRGVTKRSLSPH	FURIN	66	P09958
HRGMHTSLHLWNRSS	MC4R	6	P32245
KEQGHTRRHDWGHEK	KNG1	421	P01042
WGHEKQRKHNLGHGH	KNG1	431	P01042
ENRRITGRAHWGSHH	FAM120B	851	Q96EK7
KDHHWSRGTLRHISE	PTPN13	1216	Q12923
AGVHSVGLTWIHKLH	NUP88	411	Q99567
RGWAVGAARESTHHK	TRIM41	496	Q8WV44
THKHWDHSGGNRDLS	PNKD	171	Q8N490
HTWRKHSRHPSGGNS	REPS1	176	Q96D71
SHLKAHLRWHTGERP	SP5	311	Q6BEB4
DSHTHVSRQGAWKVH	SOCS5	346	O75159
DVHLGIAHTRWATHG	GFPT1	86	Q06210
TSHLKAHLRWHTGER	SP9	346	P0CG40
SHLKAHLRWHTGERP	SP8	371	Q8IXZ3
LRWHSSNLGKKIHDH	ADAMDEC1	291	O15204
WKSHLIEHQRTHTGE	ZNF189	271	O75820
WREHLVRHRKTHSGA	ZNF444	261	Q8N0Y2
NSHLISHWRIHTGEK	ZNF160	381	Q9HCG1
RKAHLTEHQRTHIGW	ZNF157	481	P51786
WGSHLTQHQRVHTGE	ZNF519	471	Q8TB69
GKASHLKAHLRWHTG	SP7	306	Q8TDD2
SRKSHLISHWRTHTG	ZNF84	301	P51523
RSHLWGHQRTHTGEK	ZNF677	471	Q86XU0
SHKSSLINHWRVHTG	ZNF773	341	Q6PK81
IGWISHHDGHRVHKS	ZNF226	206	Q9NYT6
RSGLARHWSIHTGEK	ZNF841	661	Q6ZN19
LASHWRTHTGEKPHR	ZNF835	181	Q9Y2P0
SHISRGHQHQAWGSR	FARS2	21	O95363
AWNSHLVRHTRIHSG	ZNF600	396	Q6ZNG1
AFTWSAGLHKHRRTH	ZNF486	386	Q96H40
RDGWSRVHNDHSHLG	SPATA6	281	Q9NWH7
SWTSHHIRDGIRHGL	TMEM267	151	Q0VDI3
SWNSHLIVHKRIHTG	ZNF606	466	Q8WXB4
SHLEGHRVTWTGRFK	WFS1	691	O76024
NWSSHLTTHKRIHTG	ZNF737	211	O75373
SHWSKLTRHQRTHTG	ZNF787	76	Q6DD87