Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	1.15e-06	431	80	11	GO:0004984
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	MAN2A2 MAN2A1	1.59e-05	2	80	2	GO:0004572
GeneOntologyMolecularFunction	alpha-mannosidase activity	MAN2A2 MAN2B2 MAN2A1	2.72e-05	15	80	3	GO:0004559
GeneOntologyMolecularFunction	mannosidase activity	MAN2A2 MAN2B2 MAN2A1	3.34e-05	16	80	3	GO:0015923
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T8 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 FZD5 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	4.63e-05	884	80	13	GO:0004930
GeneOntologyMolecularFunction	mannosyl-oligosaccharide mannosidase activity	MAN2A2 MAN2A1	6.99e-04	10	80	2	GO:0015924
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2T8 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 FZD5 OR10W1 OR8S1 OR2T12 OR51G1 PTPRT OR4K14 OR11H6	8.91e-04	1353	80	14	GO:0004888
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	5.78e-07	432	77	11	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	1.19e-06	465	77	11	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	1.79e-06	485	77	11	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	3.76e-06	524	77	11	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	5.66e-06	547	77	11	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	1.02e-05	582	77	11	GO:0050906
GeneOntologyBiologicalProcess	mannose metabolic process	MAN2A2 MAN2B2 MAN2A1	1.07e-05	12	77	3	GO:0006013
GeneOntologyBiologicalProcess	detection of stimulus	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	7.30e-05	722	77	11	GO:0051606
GeneOntologyBiologicalProcess	positive regulation of T cell cytokine production	DENND1B FZD5 GATA3	1.37e-04	27	77	3	GO:0002726
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2T8 ADCY10 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 FZD5 OR10W1 TENM1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	1.73e-04	1395	77	15	GO:0007186
MousePheno	abnormal conotruncal ridge morphology	SHROOM3 MYH10 GATA3	4.42e-05	17	58	3	MP:0010585
MousePheno	abnormal conotruncus morphology	SHROOM3 MYH10 GATA3	5.29e-05	18	58	3	MP:0010583
Domain	-	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	1.20.1270.50
Domain	-	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	3.20.110.10
Domain	Glyco_hydro_38_C	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	SM00872
Domain	Alpha-mann_mid	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	PF09261
Domain	Glyco_hydro_38_N	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	IPR027291
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	IPR015341
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	IPR028995
Domain	Glyco_hydro_38C	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	PF07748
Domain	Glyco_hydro_38	MAN2A2 MAN2B2 MAN2A1	7.52e-07	5	80	3	PF01074
Domain	Olfact_rcpt	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	8.88e-07	393	80	11	IPR000725
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A2 MAN2B2 MAN2A1	2.62e-06	7	80	3	IPR011330
Domain	GPCR_Rhodpsn_7TM	OR2T8 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	2.66e-05	670	80	12	IPR017452
Domain	-	MAN2A2 MAN2B2 MAN2A1	2.66e-05	14	80	3	2.60.40.1180
Domain	uDENN	DENND1B DENND1C DENND1A	2.66e-05	14	80	3	SM00800
Domain	7tm_1	OR2T8 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	2.94e-05	677	80	12	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T8 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	3.30e-05	685	80	12	PS00237
Domain	Glyco_hydro_b	MAN2A2 MAN2B2 MAN2A1	3.32e-05	15	80	3	IPR013780
Domain	uDENN	DENND1B DENND1C DENND1A	3.32e-05	15	80	3	PF03456
Domain	G_PROTEIN_RECEP_F1_2	OR2T8 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	3.59e-05	691	80	12	PS50262
Domain	GPCR_Rhodpsn	OR2T8 OR51S1 OR2T33 P2RY6 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	3.64e-05	692	80	12	IPR000276
Domain	UDENN	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	PS50946
Domain	DDENN	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	PS50947
Domain	DENN	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	SM00799
Domain	dDENN	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	SM00801
Domain	DENN	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	PF02141
Domain	dDENN_dom	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	IPR005112
Domain	uDENN_dom	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	IPR005113
Domain	dDENN	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	PF03455
Domain	DENN	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	PS50211
Domain	DENN_dom	DENND1B DENND1C DENND1A	4.07e-05	16	80	3	IPR001194
Domain	Gal_mutarotase_SF_dom	MAN2A2 MAN2B2 MAN2A1	4.93e-05	17	80	3	IPR011013
Domain	Fe_hydrogenase	CIAO3 OPHN1	5.42e-05	3	80	2	IPR009016
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	2.05e-06	417	63	11	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	7.91e-06	389	63	10	M14091
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS	MAN2A2 MAN2A1 ST6GAL1	4.57e-05	16	63	3	M47632
Pathway	REACTOME_SENSORY_PERCEPTION	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR4K14 OR11H6	1.05e-04	636	63	11	M41834
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	MAN2A2 MAN2A1 ST6GAL1	2.06e-04	26	63	3	M979
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	MAN2A2 MAN2A1 ST6GAL1	2.86e-04	29	63	3	MM15699
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR11H6	6.28e-09	340	80	10	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR11H6	6.28e-09	340	80	10	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR11H6	6.82e-09	343	80	10	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2T8 OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR8S1 OR2T12 OR51G1 OR11H6	7.41e-09	346	80	10	14611657
Pubmed	The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.	DENND1B DENND1C DENND1A	1.17e-08	3	80	3	20154091
Pubmed	The human olfactory receptor gene family.	OR51S1 OR2T33 OR6K2 OR11H4 OR10W1 OR2T12 OR51G1 OR4K14 OR11H6	4.34e-06	541	80	9	14983052
Pubmed	Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors.	DENND1B DENND1A	5.23e-06	2	80	2	26055712
Pubmed	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.	MAN2A2 MAN2A1	5.23e-06	2	80	2	8524845
Pubmed	Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia.	MAN2A2 MAN2B2	5.23e-06	2	80	2	9425289
Pubmed	Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.	SETDB1 NFIX	5.23e-06	2	80	2	34026436
Pubmed	N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.	MAN2A2 MAN2A1	5.23e-06	2	80	2	17113875
Pubmed	Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.	MAN2A2 MAN2A1	5.23e-06	2	80	2	11778047
Pubmed	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.	MAN2A2 MAN2A1	5.23e-06	2	80	2	16754854
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN2A2 MAN2B2 MAN2A1	5.23e-06	15	80	3	8892864
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN2A2 MAN2B2 MAN2A1	7.79e-06	17	80	3	2355006
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN2A2 MAN2B2 MAN2A1	1.30e-05	20	80	3	12560567
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	MISP MYH10 GSE1 GATA3 BTAF1 PCID2 NUP205	1.41e-05	341	80	7	32971831
Pubmed	Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens.	KLK4 ST6GAL1	1.57e-05	3	80	2	29288201
Pubmed	Post-GWAS Validation of Target Genes Associated with HbF and HbA2 Levels.	CCND3 NFIX	1.57e-05	3	80	2	39056767
Pubmed	Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.	SETDB1 UHRF1	1.57e-05	3	80	2	27151458
Pubmed	Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing.	SETDB1 UHRF1	1.57e-05	3	80	2	33998651
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN2A2 MAN2B2 MAN2A1	1.75e-05	22	80	3	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	MAN2A2 MAN2B2 MAN2A1	1.75e-05	22	80	3	9109416
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	MAN2A2 MAN2B2 MAN2A1	1.75e-05	22	80	3	11530211
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	MAN2A2 MAN2B2 MAN2A1	2.01e-05	23	80	3	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	MAN2A2 MAN2B2 MAN2A1	2.01e-05	23	80	3	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	MAN2A2 MAN2B2 MAN2A1	2.01e-05	23	80	3	3099781
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	MAN2A2 MAN2B2 MAN2A1	2.01e-05	23	80	3	3264072
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	MAN2A2 MAN2B2 MAN2A1	2.60e-05	25	80	3	2283726
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	MAN2A2 MAN2B2 MAN2A1	2.93e-05	26	80	3	8218172
Pubmed	NFIA and GATA3 are crucial regulators of embryonic articular cartilage differentiation.	NFIX GATA3	3.13e-05	4	80	2	29247144
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TBC1D19 CCND3 SHROOM3 MYH10 KLK4 MAN2B2 DENND1B NFIX BTAF1 TTYH3 IDE DENND1A CDC42BPB	3.35e-05	1489	80	13	28611215
Pubmed	A genetic approach to Mammalian glycan function.	MAN2A2 MAN2A1 ST6GAL1	4.55e-05	30	80	3	12676797
Pubmed	Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis.	SHROOM3 MYH10	5.20e-05	5	80	2	21726547
Pubmed	Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network.	SHROOM3 MYH10	7.79e-05	6	80	2	16249236
Pubmed	Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.	ELOA REXO1	7.79e-05	6	80	2	12943681
Pubmed	An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.	DENND1B DENND1A	7.79e-05	6	80	2	33443570
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	MAN2A2 MAN2B2 MAN2A1	8.61e-05	37	80	3	2541446
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	MAN2A2 MAN2B2 MAN2A1	8.61e-05	37	80	3	2542563
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	DENND1B DENND1C DENND1A	8.61e-05	37	80	3	20937701
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	MAN2A2 MAN2B2 MAN2A1	9.33e-05	38	80	3	2829950
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	MAN2A2 MAN2B2 MAN2A1	9.33e-05	38	80	3	2187500
Pubmed	Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.	SHROOM3 MYH10	1.09e-04	7	80	2	25596276
Pubmed	Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition.	SHROOM3 MYH10	1.09e-04	7	80	2	26902112
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STARD8 MAN2B2 TOGARAM1 TTYH3 KLHDC10 CDC42BPB REXO1	1.43e-04	493	80	7	15368895
Pubmed	p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.	SHROOM3 MYH10	1.45e-04	8	80	2	25038041
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR2T8 OR11H4 OR2T12	1.66e-04	46	80	3	32126975
Pubmed	Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.	MAN2A2 MAN2B2 MAN2A1	1.66e-04	46	80	3	2649653
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	TBC1D19 ELOA MYH10 BTAF1 SMC5 CDC42BPB	1.86e-04	360	80	6	33111431
Pubmed	Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.	ELOA UHRF1	2.32e-04	10	80	2	36376892
Pubmed	HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments.	MAN2A2 MAN2A1	2.32e-04	10	80	2	18215327
Pubmed	β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis.	CCND3 SP7	2.32e-04	10	80	2	21108844
Pubmed	Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility.	MAN2A2 MAN2A1	2.32e-04	10	80	2	18330979
Pubmed	Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses.	MAN2A2 MAN2A1	2.32e-04	10	80	2	18314154
Pubmed	GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis.	GATA3 SP7	3.40e-04	12	80	2	36449606
Pubmed	Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.	SHROOM3 MYH10	6.14e-04	16	80	2	15037549
Pubmed	GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.	SHROOM3 MYH10	6.95e-04	17	80	2	29237740
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	SETDB1 UHRF1	7.81e-04	18	80	2	24025402
Pubmed	Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.	LBH F8	7.81e-04	18	80	2	21810271
Pubmed	TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.	MYH10 UHRF1	7.81e-04	18	80	2	34729304
Pubmed	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.	ADAM30 IDE	9.66e-04	20	80	2	19862325
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCND3 SHROOM3 MAN2A2 INTS11 BTAF1 TTYH3 DENND1A CDC42BPB REXO1	9.82e-04	1105	80	9	35748872
Pubmed	Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.	ADAM30 IDE	1.07e-03	21	80	2	18591388
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	TMEM182 BACH2 ST6GAL1 PTPRT	1.17e-03	199	80	4	23382691
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	DENND1B BACH2 INTS11 ADAM30 TTYH3	1.17e-03	342	80	5	23128233
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	SETDB1 IDE KLHDC10 CDC42BPB	1.40e-03	209	80	4	26389662
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CCND3 ELOA KLK4 ADAM30 KDM1B MAPK4 CDC42BPB	1.47e-03	730	80	7	34857952
Pubmed	Neural tube defects by NUAK1 and NUAK2 double mutation.	SHROOM3 MYH10	1.51e-03	25	80	2	22689267
Pubmed	Human transcription factor protein interaction networks.	SETDB1 NR2C2 MYH10 GSE1 NFIX GATA3 KDM1B PCMT1 NUP205 SP7	1.60e-03	1429	80	10	35140242
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	ELOA REXO1	1.64e-03	26	80	2	33298525
Pubmed	Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.	SETDB1 MAN2A1	2.04e-03	29	80	2	12652657
Pubmed	Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.	SHROOM3 MYH10	2.04e-03	29	80	2	30228103
Pubmed	Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro.	SHROOM3 NFIX	2.18e-03	30	80	2	29555813
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	FNIP2 SETDB1 CATIP STARD8 MAN2B2 DENND1B BACH2 DENND1C IDE	2.19e-03	1242	80	9	30973865
Cytoband	19p13.3	MISP NFIX UHRF1 DENND1C REXO1	6.16e-05	237	80	5	19p13.3
Cytoband	14q11.2	OR11H4 CMA1 OR4K14 OR11H6	2.86e-04	180	80	4	14q11.2
Cytoband	Xq12	ZC3H12B OPHN1	9.48e-04	26	80	2	Xq12
Cytoband	1q44	OR2T8 OR2T33 OR2T12	9.62e-04	110	80	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T8 OR2T33 OR2T12	1.49e-03	128	80	3	chr1q44
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2B2 MAN2A1	2.80e-07	5	56	3	1194
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	FNIP2 DENND1B DENND1C DENND1A	9.95e-07	25	56	4	504
GeneFamily	Olfactory receptors, family 11	OR11H4 OR11H6	2.29e-03	23	56	2	159
Disease	nervousness	AGBL2 DENND1A	7.08e-04	16	73	2	NCIT_C74532
Disease	Intrahepatic cholestasis of pregnancy	SHROOM3 ABCG8	7.08e-04	16	73	2	EFO_0009048
Disease	inflammatory bowel disease	CCND3 DENND1B BACH2 INTS11 ADAM30 ITGB8	8.65e-04	449	73	6	EFO_0003767
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	GSE1 BACH2 PTPRT	1.08e-03	81	73	3	EFO_0803334
Disease	cholelithiasis	SHROOM3 UGT1A5 ABCG8	1.37e-03	88	73	3	EFO_0004799
Disease	cortical surface area measurement	FNIP2 SHROOM3 MYH10 DENND1B NFIX UHRF1 DENND1A ITGB8 PCMT1 SP7	1.70e-03	1345	73	10	EFO_0010736
Disease	Inhalant adrenergic use measurement	BACH2 GATA3 ITGB8	1.76e-03	96	73	3	EFO_0009941
Disease	anxiety	TMEM182 DENND1B AGBL2 DENND1A	2.30e-03	223	73	4	EFO_0005230
Disease	gallstones	SHROOM3 UGT1A5 ABCG8	2.46e-03	108	73	3	EFO_0004210
Disease	eosinophil percentage of leukocytes	GSE1 BACH2 GATA3 ST6GAL1 ITGB8 MASP2 NUP205	2.47e-03	746	73	7	EFO_0007991
Disease	rheumatoid arthritis, celiac disease	BACH2 LBH	3.03e-03	33	73	2	EFO_0000685, EFO_0001060

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPDSPMYVYESTVHC	BACH2	6	Q9BYV9
LCVLFVSHFYTPMPD	AADACL2	11	Q6P093
LALCATDYTFAMYPP	CCND3	186	P30281
SPHCDLFPGASYLMT	ARHGEF5	416	Q12774
PHPAFRMDDSYCLSA	GSE1	261	Q14687
LPEHCAYIIIYGMPT	ABCG8	501	Q9H221
GPVFCPRLYHLMAYV	ADCY10	1506	Q96PN6
PHMPTYLVAFVICDY	LVRN	301	Q6Q4G3
PAAYLNPCSAMDYSL	SDHD	81	O14521
LDYCCAPMPYLIGVH	DENND1C	256	Q8IV53
PMPEYLNVHYICESA	NR2C2	376	P49116
HYLAICSPLHYPSIM	OR6K2	121	Q8NGY2
MGHPPLEFSDCYLDS	OPHN1	1	O60890
HYAFMLDSCFTSPPP	NUP205	1366	Q92621
MQYRHSKPCPDYVSH	PAQR3	296	Q6TCH7
EVCSKLYDPLYHPSM	KLK4	176	Q9Y5K2
SLPYMTCPGNHEERY	ACP7	196	Q6ZNF0
DTSYTYHLVCMGPEA	MISP	26	Q8IVT2
MEFVFLAYPSCPELH	OR10W1	1	Q8NGF6
IYAVRCNPLLHTPMY	OR11H4	56	Q8NGC9
YLAICRPLHYPSIMT	OR11H6	141	Q8NGC7
YAAVCHPLRYPTLMS	OR2T12	121	Q8NG77
MYSPYCLTQDEFHPF	NFIX	1	Q14938
CHMMPFYSYDIPHTC	MAN2A1	346	Q16706
YDGPIYMTHPTQAIC	INTS11	86	Q5TA45
GLQHPYMSPYSCPED	MAPK4	306	P31152
MSIYFPIHCPDYLRS	LBH	1	Q53QV2
LPATMPEPVYFHCAA	KLHDC10	356	Q6PID8
YAAVCHPLRYPTLMS	OR2T8	121	A6NH00
ICTDATLHGPMYYFL	OR51G1	51	Q8NGK1
LAYMPYCLPQVLTHS	OR51S1	171	Q8NGJ8
SDPCLHSSPMYFLLG	OR4K14	51	Q8NGD5
MASDPLCLTYSYLSH	F8	166	P00451
EYLLCFSHMGLYVDP	CDC42BPB	1436	Q9Y5S2
YAAVCHPLRYPTLMS	OR2T33	121	Q8NG76
QTHPYRTCDPVEMSY	PTPRT	846	O14522
CSDYNLDCMPPHGYI	ITGB8	211	P26012
PPYDEMFAAHLRCTY	PCID2	56	Q5JVF3
LCSMYTPICLPDYHK	FZD5	86	Q13467
LSHSYMDAAQYPLPE	GATA3	31	P23771
EDHPYIPKDCNYMGS	ADAM30	101	Q9UKF2
AAPLLSAYYPDCVGM	KDM1B	216	Q8NB78
QHLPHLYMCLQYPST	BTAF1	1106	O14981
PPSCTSPHQMYVDHY	ELOA	206	Q14241
PGNTPIMYYCHEFSS	GALNT8	516	Q9NY28
YCPTYMPDLVLHGTG	FNIP2	951	Q9P278
PMSCQYYLLSDGHLA	CATIP	241	Q7Z7H3
GCAAMAAYPSLHIYT	AGBL2	886	Q5U5Z8
CHMMPFYSYDVPHTC	MAN2A2	346	P49641
MDQYSYCTPSHIPFS	MAN2B2	211	Q9Y2E5
IHYTSTAQPCPYPMA	MASP2	291	O00187
LDYCCAPMPYLIGIH	DENND1A	236	Q8TEH3
PFAYVDPLHCNMAYL	IDE	581	P14735
TACIHGSAALLYPMY	DENND1B	226	Q6P3S1
YCCAPMPYLIGIHSS	DENND1B	256	Q6P3S1
MEANHCSLGVYPSYP	SLFN13	1	Q68D06
PPHIYAISESAYRCM	MYH10	151	P35580
VCYDLSPPALATHYM	P2RY6	176	Q15077
ASIFIMMPCHSTPYY	PIGB	431	Q92521
STPYYSHVHCPLPMR	PIGB	441	Q92521
THPGIYALDCEMSYT	REXO1	1056	Q8N1G1
PTYPHFYSEICNMLR	UTP25	691	Q68CQ4
DRSHYAKCNPYMDSP	PCMT1	36	P22061
MTIAYCTNNAHPPDY	NXPE2	531	Q96DL1
SMLVNCPAYYSVSAP	SHROOM3	1741	Q8TF72
DSACTMGAYHPLLYE	ST6GAL1	361	P15907
LSTSPAHKYYLAMDP	TENM1	1231	Q9UKZ4
HYSYEMPSLLPLSCS	OR8S1	176	Q8NH09
LYHYVTDSMAPHPCR	STARD8	906	Q92502
APMEKLFYLPHVCSY	SETDB1	566	Q15047
PYHYVEVMACPSGCL	CIAO3	386	Q9H6Q4
TECKPHSRPYMAYLE	CMA1	26	P23946
CLPSVYTSLDMTHPY	SP7	121	Q8TDD2
YPLALSYLCHAVSAP	UGT1A5	216	P35504
GYHSYPLSNSLMQPC	ZC3H12B	741	Q5HYM0
CDMAFHIYCLDPPLS	UHRF1	336	Q96T88
RDSMHIYGSYSPTIC	TOGARAM1	631	Q9Y4F4
DAPDPVMSYLCCQYH	SMC5	571	Q8IY18
MYVAPLCFLYHEPSK	TBC1D19	371	Q8N5T2
DSLYRVHMPSLYSCG	TTYH3	436	Q9C0H2
CTHAYLSPYPFMRGE	TMEM182	86	Q6ZP80
MLYNPSPDYVTTVHC	JKAMP	131	Q9P055