Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein kinase activity

PASK AURKC FLT4 EPHA6 ATR FASTK MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6

2.18e-066008813GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

PASK AURKC FLT4 EPHA6 ATR FASTK MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6 PDXK

2.52e-067098814GO:0016773
GeneOntologyMolecularFunctionkinase activity

PASK AURKC FLT4 EPHA6 ATR FASTK MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6 PDXK

5.96e-067648814GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

PASK AURKC FLT4 EPHA6 ATR FASTK MAP3K14 PAK2 DKC1 PRKCA TNK2 ROS1 FGFR1 MAP3K6 PDXK

1.37e-059388815GO:0016772
GeneOntologyMolecularFunctionprotein serine kinase activity

PASK AURKC ATR FASTK MAP3K14 PAK2 PRKCA TNK2 MAP3K6

3.17e-05363889GO:0106310
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

PASK AURKC ATR FASTK MAP3K14 PAK2 PRKCA TNK2 MAP3K6

1.53e-04446889GO:0004674
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

FLT4 EPHA6 ROS1 FGFR1

1.94e-0465884GO:0004714
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

FLT4 EPHA6 TNK2 ROS1 FGFR1

4.55e-04145885GO:0004713
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

FLT4 EPHA6 ROS1 FGFR1

5.43e-0485884GO:0019199
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

8.44e-0410882GO:0001849
GeneOntologyMolecularFunction4 iron, 4 sulfur cluster binding

RSAD1 ACO1 NUBPL

1.17e-0347883GO:0051539
GeneOntologyMolecularFunctioncell adhesion molecule binding

CNTN4 EEF2 CNTN5 PAK2 PRKCA FGFR1 ADAMTS8 ITGB4 CNTN6

1.29e-03599889GO:0050839
GeneOntologyBiologicalProcessprotein autophosphorylation

PASK AURKC FLT4 ATR PAK2 PRKCA ROS1 FGFR1

6.45e-06228898GO:0046777
GeneOntologyBiologicalProcessserotonin metabolic process

FEV BTBD9 DDC

6.05e-0518893GO:0042428
GeneOntologyBiologicalProcessdendrite self-avoidance

CNTN4 CNTN5 CNTN6

6.05e-0518893GO:0070593
DomainProtein_kinase_ATP_BS

PASK AURKC FLT4 EPHA6 MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6

1.64e-063798811IPR017441
DomainKinase-like_dom

PASK AURKC FLT4 EPHA6 ATR MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6

8.72e-065428812IPR011009
DomainPROTEIN_KINASE_ATP

PASK AURKC FLT4 EPHA6 MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6

1.02e-054598811PS00107
DomainProt_kinase_dom

PASK AURKC FLT4 EPHA6 MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6

1.84e-054898811IPR000719
DomainPROTEIN_KINASE_DOM

PASK AURKC FLT4 EPHA6 MAP3K14 PAK2 PRKCA TNK2 ROS1 FGFR1 MAP3K6

1.98e-054938811PS50011
DomainFN3

CNTN4 FLNC EPHA6 CNTN5 ROS1 ITGB4 CNTN6

2.70e-05185887SM00060
DomainFN3_dom

CNTN4 FLNC EPHA6 CNTN5 ROS1 ITGB4 CNTN6

5.86e-05209887IPR003961
DomainTyr_kinase_cat_dom

FLT4 EPHA6 TNK2 ROS1 FGFR1

5.96e-0588885IPR020635
DomainTyrKc

FLT4 EPHA6 TNK2 ROS1 FGFR1

5.96e-0588885SM00219
DomainPROTEIN_KINASE_TYR

FLT4 EPHA6 TNK2 ROS1 FGFR1

9.49e-0597885PS00109
DomainTyr_kinase_AS

FLT4 EPHA6 TNK2 ROS1 FGFR1

9.49e-0597885IPR008266
Domainfn3

CNTN4 EPHA6 CNTN5 ROS1 ITGB4 CNTN6

1.17e-04162886PF00041
DomainAnaphylatoxin_comp_syst

C4A C4B

2.17e-045882IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

2.17e-045882IPR001840
DomainEFG_II

EFL1 EEF2

2.17e-045882PF14492
DomainEFG_C

EFL1 EEF2

3.25e-046882PF00679
DomainEFG_III-V

EFL1 EEF2

3.25e-046882IPR009022
DomainEFG_C

EFL1 EEF2

3.25e-046882SM00838
DomainFN3

CNTN4 EPHA6 CNTN5 ROS1 ITGB4 CNTN6

3.56e-04199886PS50853
DomainPkinase_Tyr

FLT4 EPHA6 TNK2 ROS1 FGFR1

3.60e-04129885PF07714
DomainANATO

C4A C4B

4.54e-047882SM00104
DomainANAPHYLATOXIN_2

C4A C4B

4.54e-047882PS01178
DomainANAPHYLATOXIN_1

C4A C4B

4.54e-047882PS01177
Domain-

EFL1 EEF2

4.54e-0478823.30.70.240
DomainANATO

C4A C4B

4.54e-047882PF01821
DomainEFG_V

EFL1 EEF2

4.54e-047882IPR000640
DomainAnaphylatoxin/fibulin

C4A C4B

4.54e-047882IPR000020
DomainSer-Thr/Tyr_kinase_cat_dom

FLT4 EPHA6 TNK2 ROS1 FGFR1

4.91e-04138885IPR001245
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

6.03e-048882IPR019565
DomainThiol-ester_cl

C4A C4B

6.03e-048882PF10569
DomainMacrogloblnA2_CS

C4A C4B

6.03e-048882IPR019742
DomainA2M

C4A C4B

9.64e-0410882PF00207
DomainA2M_N_2

C4A C4B

9.64e-0410882IPR011625
DomainA2M_comp

C4A C4B

9.64e-0410882IPR011626
DomainA2M_recep

C4A C4B

9.64e-0410882PF07677
DomainA2M_comp

C4A C4B

9.64e-0410882PF07678
DomainA2M_N

C4A C4B

9.64e-0410882PF01835
DomainA2M_N

C4A C4B

9.64e-0410882IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

9.64e-0410882IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

9.64e-0410882PS00477
DomainA2M_N_2

C4A C4B

9.64e-0410882PF07703
DomainMacroglobln_a2

C4A C4B

9.64e-0410882IPR001599
Domain-

CNTN4 FLNC FLT4 EPHA6 CNTN5 ROS1 FGFR1 PLXND1 ITGB4 CNTN6

1.11e-0366388102.60.40.10
DomainG_TR_1

EFL1 EEF2

1.66e-0313882PS00301
DomainIg-like_fold

CNTN4 FLNC FLT4 EPHA6 CNTN5 ROS1 FGFR1 PLXND1 ITGB4 CNTN6

1.77e-037068810IPR013783
DomainATPase_dyneun-rel_AAA

VWA8 DNAH5

1.93e-0314882IPR011704
DomainAAA_5

VWA8 DNAH5

1.93e-0314882PF07728
DomainIg_I-set

CNTN4 FLT4 CNTN5 FGFR1 CNTN6

2.05e-03190885IPR013098
DomainI-set

CNTN4 FLT4 CNTN5 FGFR1 CNTN6

2.05e-03190885PF07679
DomainC345C

C4A C4B

2.85e-0317882SM00643
DomainEFTu-like_2

EFL1 EEF2

3.20e-0318882IPR004161
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

3.20e-0318882IPR008930
DomainGTP_EFTU_D2

EFL1 EEF2

3.20e-0318882PF03144
DomainG_TR_2

EFL1 EEF2

3.20e-0318882PS51722
DomainTF_GTP-bd_dom

EFL1 EEF2

3.56e-0319882IPR000795
DomainNTR

C4A C4B

3.56e-0319882PF01759
DomainNetrin_module_non-TIMP

C4A C4B

3.56e-0319882IPR018933
DomainCRIB

PAK2 TNK2

3.95e-0320882PS50108
Domain-

EFL1 EEF2

4.35e-03218823.30.230.10
DomainCRIB_dom

PAK2 TNK2

4.35e-0321882IPR000095
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

PASK AURKC FLT4 FASTK MAP3K14 TCF25 PRKCA TNK2 FGFR1 MAP3K6

5.75e-08372921022939624
Pubmed

Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.

CNTN4 CNTN5 CNTN6

1.78e-07592327539848
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DOCK3 FLNC EPPK1 VWA8 BICRA CUL9 TNK2 DDX56 CLASP2 FGFR1 PLXND1 NUBPL ARRDC2 ITGB4 CASZ1

2.06e-071105921535748872
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

CNTN4 FAT2 FLT4 C4A FGFR1 PLXND1 CTSD ITGB4

4.34e-0725792816335952
Pubmed

The protein tyrosine kinase family of the human genome.

FLT4 EPHA6 TNK2 ROS1 FGFR1

2.86e-068392511114734
Pubmed

A role for Nr-CAM in the patterning of binocular visual pathways.

CNTN4 CNTN5 CNTN6

3.87e-061292316701205
Pubmed

Mapping of the L-methylmalonyl-CoA mutase gene to mouse chromosome 17.

C4A C4B MMUT

5.03e-06139231970332
Pubmed

Pioneering axons regulate neuronal polarization in the developing cerebral cortex.

CNTN4 CNTN5 CNTN6

5.03e-061392324559674
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

6.92e-06292222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

6.92e-06292216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

6.92e-06292215998580
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

6.92e-0629227373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

6.92e-06292219062096
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

6.92e-0629223696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

6.92e-0629221357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

6.92e-06292216098595
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

6.92e-06292219933335
Pubmed

Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes.

PRKCA ITGB4

6.92e-06292215121854
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

6.92e-0629222459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

6.92e-06292217645767
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

6.92e-06292215787745
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

6.92e-06292212207352
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

6.92e-06292230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

6.92e-0629226559257
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

6.92e-06292227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

6.92e-06292222387014
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

6.92e-06292234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

6.92e-06292220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

6.92e-06292212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

6.92e-06292226800705
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

6.92e-06292223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

6.92e-06292223918728
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

6.92e-06292215390104
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

6.92e-0629223037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

6.92e-06292211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

6.92e-0629224216347
Pubmed

Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells.

PRKCA ITGB4

6.92e-06292210477766
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

6.92e-0629221699796
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

6.92e-0629226950384
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

6.92e-0629222997024
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

6.92e-0629228660986
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

6.92e-0629223624865
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

6.92e-0629228428773
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

6.92e-06292221857912
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

6.92e-06292224638111
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

6.92e-0629226208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

6.92e-0629224514997
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

6.92e-06292221345967
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

6.92e-0629225919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

6.92e-0629223167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

6.92e-0629227545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

6.92e-06292230041577
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

6.92e-0629222572548
Pubmed

The complement component C4 of mammals.

C4A C4B

6.92e-0629222302180
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

6.92e-0629223862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

6.92e-06292234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

6.92e-06292218360261
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

6.92e-06292222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

6.92e-06292218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

6.92e-06292229080553
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

6.92e-06292226814963
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

6.92e-0629226589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

6.92e-06292225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

6.92e-06292217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

6.92e-0629226149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

6.92e-0629226149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

6.92e-06292212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

6.92e-0629223542363
Pubmed

Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis.

FLT4 FGFR1

6.92e-06292222761819
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

6.92e-0629222387317
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

6.92e-0629228132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

6.92e-0629222395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

6.92e-06292226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

6.92e-0629226192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

6.92e-0629226167582
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

6.92e-06292216908004
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

6.92e-0629221438267
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

6.92e-0629227365238
Pubmed

IRF6 Regulates the Expression of IL-36γ by Human Oral Epithelial Cells in Response to Porphyromonas gingivalis.

IRF6 IL36G

6.92e-06292226819203
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

6.92e-06292219150565
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

6.92e-0629227391573
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

6.92e-06292217506029
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

6.92e-06292217971360
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

6.92e-06292223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

6.92e-0629223464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

6.92e-0629222993295
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

6.92e-06292229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

6.92e-06292217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

6.92e-0629226881182
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

6.92e-0629223944109
Pubmed

Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis.

IRF6 FGFR1

6.92e-06292217318851
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

6.92e-06292217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

6.92e-06292221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

6.92e-0629226978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

6.92e-06292235898513
Pubmed

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.

C4A C4B

6.92e-06292233353966
Pubmed

Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).

C4A C4B

6.92e-0629223008092
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

6.92e-06292228873507
Pubmed

The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.

C4A C4B

6.92e-0629226609966
Pubmed

Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.

C4A C4B

6.92e-0629222900855
InteractionACSM5 interactions

RSAD1 VWA8 FDXR ACSF2 MMUT

4.15e-0655885int:ACSM5
InteractionAMACR interactions

RSAD1 VWA8 FPGS ACSF2 MMUT

1.10e-0567885int:AMACR
GeneFamilyFibronectin type III domain containing

CNTN4 EPHA6 CNTN5 ROS1 ITGB4 CNTN6

7.95e-06160546555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

CNTN4 FLT4 CNTN5 FGFR1 CNTN6

1.17e-04161545593
GeneFamilyReceptor Tyrosine Kinases|CD molecules

FLT4 ROS1 FGFR1

2.30e-0440543321
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

3.11e-0495421234
GeneFamilyWiskott-Aldrich Syndrome protein family

WASH3P WASH4P

1.02e-031654214
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K14 MAP3K6

2.32e-0324542654
GeneFamilyComplement system|Sushi domain containing

C4A C4B

5.17e-0336542492
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B

5.45e-0337542454
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK3 CNTN4 FLNC ADAM19 C4A ADAMTS8

3.40e-06197926ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-Tfh|Lung / Manually curated celltypes from each tissue

PASK TNFRSF25 EPPK1 SYNE2 PRKCA

1.15e-05142925319812c84fad93276bf093f2ad78db02ae745bf4
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 EPHA6 ROS1 NME8 CNTN6

1.27e-0514592596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellLPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNC MARS1 FDXR IRF6 RAC3

1.87e-05157925bd45590da540a557dc8096980a45220fccb99505
ToppCellLPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNC MARS1 FDXR IRF6 RAC3

1.87e-0515792500c9a58b033b8b95b0d838f233dd077b62d8b02a
ToppCelldroplet-Limb_Muscle-nan-3m-Myeloid-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTN4 AURKC IRF6 DDC PADI3

2.44e-051669250a7992bc673fca546636563ec3fc17a4298ab6b1
ToppCellEpithelial-basal_cell|World / Lineage, Cell type, age group and donor

CNTN4 FAT2 IRF6 ITGB4 CNTN6

3.50e-05179925d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PASK TNFRSF25 ADAM19 SYNE2 PRKCA

3.79e-051829259ba85f621a846531a2a7861e9df695d288c9e149
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 EPHA6 PLXND1 MAP3K6 ITGB4

4.10e-05185925f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK3 FLNC ADAM19 FGFR1 ADAMTS8

4.10e-05185925e58a009aaf342be019a909747b1895d5987d4daf
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CNTN4 ROS1 BTBD9 DNAH5 AGBL1

4.21e-051869252ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.21e-0518692537b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNC SGSM1 IRF6 PLXND1 ITGB4

4.21e-05186925c116cc9f41971622264434ebe29d18e719b0ae19
ToppCellHealthy-MAIT|Healthy / disease group, cell group and cell class

CNTN4 TNFRSF25 FLT4 SYNE2 SCART1

4.21e-05186925028061f06d86e75cb06db56b199594b80f23fa58
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 CNTN5 SYNE2 ACSF2 SLC5A1

4.21e-05186925b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.31e-05187925380c3e0bc73b266718893a3b3ca207ce5fd31883
ToppCelldroplet-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.31e-051879255b3c3c6421efd25c740ae121968b5520bbdc07b2
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

CNTN4 ROS1 BTBD9 DNAH5 AGBL1

4.31e-0518792581cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNFRSF25 FLT4 SYNE2 SCART1 PLXND1

4.31e-05187925f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AHI1-DT SYNE2 MAP3K14 FGFR1 TNS3

4.31e-05187925c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.31e-05187925796046ff066a9c3847faa9bf1f8beccd956c01f7
ToppCellfacs-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.31e-05187925fe9fc21192ede2eea61f419d20ccda254569d0a6
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.42e-051889258ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK3 FLNC ADAM19 FGFR1 ADAMTS8

4.42e-051889254d1e5f85342ae550086609d7680e32730b78b5d2
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

EPPK1 ROS1 BTBD9 DNAH5 AGBL1

4.42e-05188925ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.42e-05188925137ed9958044fab7a13648affb469585d1c48cf6
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM19 MAP3K14 C4A C4B

4.52e-0595924a09443e527d37adb637a66ca857525dab1c39a9b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 AHI1-DT SYNE2 PDXK TNS3

4.54e-05189925904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCelldroplet-Trachea-3m-Epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.65e-051909250114cf48612d78c3ada4d8a05850501fef6892c5
ToppCellMesenchymal-airway_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

DOCK3 FLNC ADAM19 FGFR1 ADAMTS8

4.65e-05190925645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.65e-0519092501e7747547ea1f3049a11a1717565ba71dd52bdc
ToppCelldroplet-Trachea-nan-3m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.65e-05190925e647f9a2dcf7f2dffef53c45bbe171416518fd59
ToppCelldroplet-Trachea-nan-3m-Epithelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 EPPK1 IRF6 ITGB4 CASZ1

4.65e-05190925434de72dde09644efbddcaa643a4a3eaf5f643bf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 AHI1-DT SYNE2 DNAH5 TNS3

4.77e-05191925d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK3 EPHA6 IRF6 DNAH5 CNTN6

4.77e-0519192560ff989fe99d243a3d52955223680cdd1f1917a4
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC LRRC42 IRF6 ITGB4 GARIN2

4.77e-051919254bfdf44d4402a42530d30c89d94946acdda4321b
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PASK TNFRSF25 ADAM19 SYNE2 PRKCA

4.77e-05191925142f98cabf8737b28369315b3d7a0797ded88e03
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTN4 PRKCA ROS1 DNAH5 AGBL1

4.89e-05192925cc9911e182a289779a2612bc213daae5607689e7
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC FLT4 IRF6 ITGB4 GARIN2

5.01e-05193925d0a5f212f8e8a13dbbe3e41df92548ef82eef70b
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PASK TNFRSF25 ADAM19 SYNE2 PRKCA

5.01e-05193925194b49c152e3e3f599068ec88a7f0af6427b743a
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNK2 IRF6 ITGB4 CASZ1 RAC3

5.01e-0519392522ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCellfacs-Trachea-nan-3m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 EPPK1 IRF6 ITGB4 CASZ1

5.14e-051949253701ca87c6dc9ccd7b4146e56371546174d26c36
ToppCellfacs-Trachea-nan-3m-Epithelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 EPPK1 IRF6 ITGB4 CASZ1

5.14e-0519492565f9bf126be26114c2c3f4c46d48318986212a92
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4|TCGA-Prostate / Sample_Type by Project: Shred V9

ADAM19 MAP3K14 FGFR1 ADAMTS8 ITGB4

5.26e-051959255562665dd3beb70e2358aa32611a337bef5731c1
ToppCellnormal_Pleural_Fluid-T/NK_cells-Naive_CD4+_T|T/NK_cells / Location, Cell class and cell subclass

PASK TNFRSF25 EEF2 ZSCAN18 PRKCA

5.39e-051969255958caed4172ca478a6d9112d50af9070c850b96
ToppCellSevere-CD4+_T|Severe / Disease group and Cell class

PASK TNFRSF25 EEF2 MSC ZSCAN18

5.39e-05196925576e0aa2ae146a86201dea21097ffe1c867956e7
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PASK TNFRSF25 EEF2 SYNE2 PRKCA

5.52e-0519792533d841f4fcff8aeb0b988d5dd072166347bc6022
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 EPPK1 IRF6 ITGB4 IL36G

5.52e-05197925fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PASK TNFRSF25 EEF2 SYNE2 PRKCA

5.52e-051979257f686353e1e08e0a0f721a6806c92d05254a77b2
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 EPPK1 IRF6 ITGB4 IL36G

5.52e-0519792561c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 EPPK1 IRF6 ITGB4 IL36G

5.52e-05197925dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCellCOVID-19_Severe-CD4+_Tcm|COVID-19_Severe / Disease condition and Cell class

PASK TNFRSF25 EEF2 ADAM19 PRKCA

5.52e-05197925f69083480ccf6f1854e5031d1a3e181bdcc8aea0
ToppCelldistal-1-Epithelial-Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FAT2 SPSB4 ITGB4 IL36G SLC5A1

5.52e-0519792525a2ccc98b973611de0d920b1b455d0b40f0d37f
ToppCelldistal-Epithelial-Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FAT2 SPSB4 ITGB4 IL36G PADI3

5.52e-0519792575b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 EPPK1 IRF6 ITGB4 IL36G

5.66e-05198925e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

TNFRSF25 FLT4 EPPK1 SYNE2 IRF6

5.66e-05198925ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PASK TNFRSF25 EEF2 ADAM19 SYNE2

5.79e-05199925b270d8274249103d3a1b4a4f8601c92fde007ed7
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

VWA8 PRKCA VTI1A CLASP2 BTBD9

5.79e-0519992594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 SYNE2 PLXND1 ARRDC2 MAP3K6

5.79e-0519992514e09eaa2335d4503de50250eb4258dd5b85b304
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte|GW10 / Sample Type, Dataset, Time_group, and Cell type.

BICRA FDXR FGFR1 ARRDC2 ANGPTL1

5.93e-0520092598a994692440cb4f505b050276f0c8022c814a21
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial|GW10 / Sample Type, Dataset, Time_group, and Cell type.

BICRA FDXR FGFR1 ARRDC2 ANGPTL1

5.93e-05200925ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-CD4+_Tcm|Bac-SEP / Disease, condition lineage and cell class

PASK TNFRSF25 EEF2 SYNE2 PRKCA

5.93e-05200925fe0e0b25fbe2c7bad6bffef17f62bf346c83fc54
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ASIC4 AGBL1 GARIN2 CNTN6

7.46e-05108924d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK3 SPSB4 ASIC4 CNTN6

8.01e-05110924c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP3K14 CUL9 C4A C4B

1.23e-04123924a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FLNC SPSB4 ADAMTS8 CASZ1

1.77e-0413592454b2aaf8d322e01a3ff6099c2422d68ecccf96b4
ToppCellCOVID-19_Convalescent-PLT_3|World / Disease Group and Platelet Clusters

IBTK EGLN2 RSAD1 VWA8

1.87e-04137924bb54bb81b450462ad521b57e1a07a80ce1678e67
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TAF6L ITGB4 IL36G NME8

1.97e-04139924505bf5a483fc2ba69377db9850c3b26ab2f416d1
ToppCellCOVID-19_Severe-MAIT|COVID-19_Severe / disease group, cell group and cell class

TNFRSF25 SYNE2 SCART1 FGFR1

2.64e-04150924923ea7ecc0aa05fb0396082cd9c3d1594135f1e0
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FLT4 IRF6 CTSD CASZ1

2.85e-04153924e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCellmild_COVID-19_(asymptomatic)-CD8+_T_naive|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

PASK TNFRSF25 SCART1 NUBPL

2.99e-04155924e2c901d5c9e42d25d7702e5e8fc19b06f7c817be
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNC FLT4 SGSM1 ITGB4

3.45e-04161924133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNC FLT4 SGSM1 ITGB4

3.45e-041619249466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOCK3 TNFRSF25 ADAM19 SYNE2

3.45e-04161924580153e131247e6ec12a1a920f050a0a763e7e87
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNC FLT4 SGSM1 ITGB4

3.45e-04161924cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4|Lung / Manually curated celltypes from each tissue

PASK PRKCA DNAH5 NALF2

3.54e-0416292491cc14aec8d580cf97a1929bc1acb00fcbcdb57a
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK3 EPHA6 ROS1 CNTN6

3.54e-04162924bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNC FLT4 SGSM1 ITGB4

3.54e-0416292496c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

SGSM1 DNAH5 DDC STPG2

3.79e-041659249795ce31689bc63f5a2d68725ef00b23a90c3846
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAF6L MSC FDXR DDC

3.79e-041659247c771f22b58989572c939ed127e637ec28dc0dca
ToppCellControl-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

FLNC C4A C4B ASIC4

3.88e-0416692432ebaefa6c074b28193fff764ee7c2c0e9357e20
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TNFRSF25 FLT4 SYNE2 SCART1

3.88e-04166924bb93db4613c067c56614ab1ca39e73ee46484387
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TNFRSF25 FLT4 SYNE2 SCART1

3.88e-04166924c1f17a028bb27b8f202bcfffa7de7373b1cdd990
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PASK TNFRSF25 SYNE2 PRKCA

3.97e-0416792483969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCellFetal_29-31_weeks-Epithelial-basal_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT2 IRF6 ITGB4 PADI3

4.06e-041689246521bead9789d626b86cbd08692c621c5a5aef33
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 FGFR1 PLXND1 MAP3K6

4.06e-0416892437249f38f8f04ec5743097259de67b106ca2b02f
ToppCellFetal_29-31_weeks-Epithelial-basal_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT2 IRF6 ITGB4 PADI3

4.15e-04169924c3ee781735a9288ce1822b230d39bb91c1415589
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNC FLT4 ADAM19 ITGB4

4.24e-041709246035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNC FLT4 ADAM19 ITGB4

4.24e-04170924c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PASK NUBPL ARRDC2 TULP2

4.24e-04170924f0b0d2d0402de3ed7322284a599646db43475761
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PASK NUBPL ARRDC2 TULP2

4.24e-04170924054360a3b05f5e41221c98b122d241b1affad26a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNC FLT4 ADAM19 ITGB4

4.24e-04170924dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCellHealthy/Control-MAIT|World / Disease group and Cell class

TNFRSF25 FLT4 SYNE2 SCART1

4.34e-0417192461515114b17816a8f9ef6a57262eb9e977b6ede4
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CUL9 FEV ASIC4 STPG2

4.34e-04171924dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CNTN4 RSAD1 FAM91A1 SLC5A1

4.43e-041729245401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCellHealthy_donor-MAIT|World / disease group, cell group and cell class (v2)

TNFRSF25 FLT4 SYNE2 SCART1

4.43e-041729246524eb2be1c78700ad367e62624a4d7eb48b54f0
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 DNAH5 ITGB4 SLC5A1

4.43e-04172924a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CNTN4 RSAD1 FAM91A1 SLC5A1

4.43e-04172924b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 DNAH5 ITGB4 SLC5A1

4.43e-041729240a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CNTN4 RSAD1 FAM91A1 SLC5A1

4.43e-0417292474dd4a7acb2cf857fed20219e4d7dc1adfbaa398
DrugBromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A

MARS1 TCF25 CUL9 PRKCA TNK2 FGFR1 TRDMT1 SLC5A1

1.07e-061959085665_UP
DrugTiapride hydrochloride [51012-33-0]; Down 200; 11uM; PC3; HT_HG-U133A

EPPK1 VWA8 SYNE2 CUL9 PLXND1 MAP3K6 RAC3

1.24e-051959077362_DN
DrugLY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A

PASK MARS1 CUL9 TNK2 IRF6 ITGB4 CASZ1

1.37e-051989076976_UP
DrugPiperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; PC3; HT_HG-U133A

TAF6L PASK TNFRSF25 PRKCA PLXND1 ASIC4 IL36G

1.37e-051989074320_UP
Diseasetotal glycated albumin

CNTN5 PRKCA

9.15e-055902EFO_0009305
DiseaseEndometrioid carcinoma ovary

TNK2 MAP3K6

9.15e-055902C0346163
DiseaseLarge cell carcinoma of lung

ATR ROS1 FGFR1

1.28e-0432903C0345958
DiseaseSquamous cell carcinoma of lung

AURKC ATR FGFR1

1.28e-0432903C0149782
DiseaseDNA methylation

CNTN4 IBTK FAM91A1 SCART1 LRRC30 ZNRF4 STPG2 TNS3 CNTN6

1.79e-04656909GO_0006306
Diseasehomocysteine measurement

MMUT PDXK TRDMT1

3.79e-0446903EFO_0004578
Diseaseglucagon-like peptide-1 measurement

BICRA AGBL1

4.07e-0410902EFO_0008465
DiseaseAdenocarcinoma of lung (disorder)

AURKC ATR FASTK TNK2 ROS1

4.29e-04206905C0152013
Diseaseocular hypertension, response to triamcinolone acetonide

VWA8 ZNRF4 ITGB4

4.57e-0449903EFO_0006954, EFO_1001069
DiseaseOligodontia

IRF6 FGFR1

5.95e-0412902C4082304
DiseaseIGF-1 measurement

DOCK3 EPHA6 SYNE2 PRKCA COX7A2L ADAMTS8 BTBD9

7.43e-04488907EFO_0004627
Diseasepulse pressure measurement, social deprivation

VTI1A ADAMTS8

8.17e-0414902EFO_0005763, EFO_0009696
DiseaseHypodontia

IRF6 FGFR1

8.17e-0414902C0020608
Diseasecleft lip (is_implicated_in)

IRF6 FGFR1

9.41e-0415902DOID:9296 (is_implicated_in)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

EEF2 FLT4 SYNE2 CTSD

1.11e-03148904C0279702
Diseaserenal cell carcinoma (is_implicated_in)

EGLN2 C4A C4B

1.24e-0369903DOID:4450 (is_implicated_in)
Diseaseacetone measurement

VWA8 SCART1

1.52e-0319902EFO_0010989
Diseaseselenium measurement, response to dietary selenium supplementation

DNAH5 CNTN6

1.69e-0320902EFO_0006331, EFO_0600021
Diseaseexercise test

CNTN5 PRKCA

1.69e-0320902EFO_0004328
Diseasedilated cardiomyopathy

FLNC PRKCA

1.69e-0320902EFO_0000407
DiseaseInfiltrating duct carcinoma of female breast

ATR FGFR1

1.86e-0321902C3165106
DiseaseBronchiectasis

DNAH5 NME8

2.04e-0322902C0006267
Diseasepolyp of large intestine, colorectal cancer

CNTN5 VTI1A

2.04e-0322902MONDO_0005575, MONDO_0021392
Diseaseotitis media (implicated_via_orthology)

FGFR1 DNAH5

2.04e-0322902DOID:10754 (implicated_via_orthology)
Diseaseneutrophil measurement

AHI1-DT FAT2 EPPK1 PADI3

2.14e-03177904EFO_0803548
Diseasemultiple sclerosis

TNFRSF25 AHI1-DT EPPK1 VWA8 MAP3K14 VTI1A NUBPL

2.29e-03594907MONDO_0005301
Diseaseheel bone mineral density, urate measurement

CNTN4 EPHA6 VWA8 VTI1A

2.37e-03182904EFO_0004531, EFO_0009270
DiseaseGlioma

ATR ROS1 FGFR1

2.42e-0387903C0017638
Diseasebrain cancer (implicated_via_orthology)

AURKC VPS26B

2.85e-0326902DOID:1319 (implicated_via_orthology)
DiseaseDegenerative polyarthritis

EEF2 ACO1 CTSD

2.92e-0393903C0029408
DiseaseOsteoarthrosis Deformans

EEF2 ACO1 CTSD

2.92e-0393903C0086743

Protein segments in the cluster

PeptideGeneStartEntry
MGVIPLEYLPGENAD

ACO1

811

P21399
GTLDYLPPEMIEGRT

AURKC

201

Q9UQB9
RLEPGKEYLIMGLDG

C4B

1676

P0C0L5
REGLELPPEGVYMVQ

CASZ1

111

Q86V15
YRGPEEEGDMLDPGL

ADAM19

611

Q9H013
PTGLPGRMALYQLDQ

ADAMTS8

436

Q9UP79
PNVEGRVMDVPGLYC

FDXR

381

P22570
LINMYLPDPVGDGLF

FEV

11

Q99581
LMGRELEYLEEVPPG

EFL1

566

Q7Z2Z2
PLILRNDGVMGEYEP

CNTN4

211

Q8IWV2
DMIIRGGENIYPAEL

ACSF2

511

Q96CM8
GNEIQRDPGYPRDLM

ANGPTL1

236

O95841
PLIMPYLDDAEVPGN

AHI1-DT

231

P0C7V0
MEGIEGRQVYPDVEP

DDC

21

P20711
PLYSEEDPNPLLGDM

ARRDC2

386

Q8TBH0
RIDELYLGNPMDPPD

TNK2

481

Q07912
YLGNPMDPPDLLSVE

TNK2

486

Q07912
SKPGLDRPEEELMQY

AGBL1

336

Q96MI9
PLTLRNDGVMGEYEP

CNTN5

286

O94779
PITYPQGLAMAREIG

RAC3

136

P60763
GLMGYQLLPLPFEEL

FASTK

506

Q14296
PEVLMGNPYRGPELE

PASK

1171

Q96RG2
IPAMDRRVITPYQDG

IBTK

931

Q9P2D0
RYVGLQNDEPPRLMG

KIAA1109

266

Q2LD37
PPLEGFVMNRVQGDY

FAM91A1

236

Q658Y4
PILLPYQFRMEEIEG

DDX56

411

Q9NY93
LQYMAPEIIDQGPRG

MAP3K6

811

O95382
LPSEIDVRQEYPGMI

PLXND1

606

Q9Y4D7
DPDLGPAGEVRYVLM

FAT2

951

Q9NYQ8
AEAQAVRYMPPEEGP

FLNC

1021

Q14315
LDPGPIYMRENGQLH

LRRC42

11

Q9Y546
ILPDNEEMVYGGLPG

NALF2

326

O75949
RAAGLRYPEPDMVDI

ASIC4

151

Q96FT7
RYPEPDMVDILNRTG

ASIC4

156

Q96FT7
PGVDIYISPNMERGR

PADI3

46

Q9ULW8
CYGLVNDDNRPIGPM

ITGB4

1256

P16144
MVEGEPPYLNENPLR

PAK2

436

Q13177
PYQGPRDIISPELMA

ATR

1106

Q13535
RGDPIYLGIQNPEMC

IL36G

71

Q9NZH8
FPDVIMPGDIRNDLY

DOCK3

411

Q8IZD9
MLAGVSEYELPEDPR

FGFR1

456

P11362
GAVPLIQGEYMIPCE

CTSD

316

P07339
PTPLVQRTDGVMGEY

CNTN6

211

Q9UQ52
DGVPVYLKRGLPDQM

COX7A2L

71

O14548
EIEPGVRDGMEYPFI

DNAJB11

211

Q9UBS4
PLYLCPMLEALEEGG

FPGS

276

Q05932
MVPLGPRLQAYPEEL

CUL9

11

Q8IWT3
LLYEGPPDDEAAMGI

EEF2

371

P13639
EPEPGRARMGVESYL

EGLN2

26

Q96KS0
YGGMRESQPEAEIPL

BTBD9

66

Q96Q07
EDELYQRMLKGPPPE

BICRA

1436

Q9NZM4
MLPGVLRYEDGIEVN

DKC1

316

O60832
RLEPGKEYLIMGLDG

C4A

1676

P0C0L4
LTMNPGYAGRQELPE

DNAH5

2081

Q8TE73
PELVEGGLEMLFGYL

LRRC30

281

A6NM36
QLDYLVVDMPPGTGD

NUBPL

176

Q8TB37
GQPVRYDMEVPDSGI

MAP3K14

906

Q99558
ILSIEEGYRLPAPMG

EPHA6

886

Q9UF33
LFYGDLGPMPDQEEL

IRF6

251

O14896
PRDLQNMLDGGEYAP

GARIN2

26

Q8N9W8
PAPDPELAAEMYQRG

RSAD1

246

Q9HA92
QEALPMRPAREGELY

TAF6L

86

Q9Y6J9
GPLELMGRELDLAPY

SYT12

111

Q8IV01
MEPLRVLELYSGVGG

TRDMT1

1

O14717
PYRVDVGNPEESLEM

SYNE2

3281

Q8WXH0
VLLYEMLAGQPPFDG

PRKCA

526

P17252
PDPDTGLYMLQLAGR

EPPK1

2406

P58107
PDPDTGLYMLQLAGR

EPPK1

4541

P58107
TLVPDLGLGMDGPYE

TNS3

536

Q68CZ2
DGEGSMYVPEDLLPV

PDXK

121

O00764
DNLPELYPAEPVMVG

STARD8

276

Q92502
FGEIRNVDIPMLDPY

AKAP17A

181

Q02040
LLLPEIMPGLIQGYD

CLASP2

1216

O75122
ELMNLTGTIPVPYRG

TSG101

51

Q99816
YEIMDGAPVRGESIP

VPS26B

231

Q4G0F5
PGLEEDMEAYVLRPA

TULP2

266

O00295
AAGEMARPQYPEIPL

NME8

121

Q8N427
EVTMRYINGLDPEPL

SPSB4

221

Q96A44
IRTEEMPGPGFYNVL

STPG2

251

Q8N412
NDLMYIADLGPGIAP

WASH4P

271

A8MWX3
DLEVREIPPQSRGMY

VTI1A

56

Q96AJ9
GYLSIIMDPGEVPLE

FLT4

811

P35916
PEGIRGYLMEVKPAN

ZNRF4

126

Q8WWF5
NDLMYIADLGPGIAP

WASH3P

256

C4AMC7
EAIYDVIGEMPPAGL

SCART1

946

Q4G0T1
PQYIILELMEGGDLL

ROS1

2021

P08922
QPRDDMEAVPGYLSL

SGSM1

266

Q2NKQ1
PGPQLYDVMDAVPAR

TNFRSF25

331

Q93038
LALLYMIENGPGEIP

TMEM19

146

Q96HH6
GVYERHMDPLLLPGE

ZSCAN18

151

Q8TBC5
YPTLVVELMPNGLRG

SLC5A1

366

P13866
ELEMLRQYGPNVPEP

VWA8

936

A3KMH1
GGYVPEMVLTPDDQR

MARS1

666

P56192
SLLPNYTMEGERPEE

TCF25

616

Q9BQ70
EMELRGLQREYPVPA

MSC

11

O60682
DILVMCGGVIPPQDY

MMUT

696

P22033