Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX4 PRRX1 FOXQ1 HDX NPAS3 NSD1 POU2F1 GBX1 KCNIP3 CASZ1 MSGN1 CREBRF ZNF18 OLIG3 STOX2 ZSCAN10 GLI2 GLI3 ZNF358 ZFHX2 EN1 NEUROG2 LRRFIP1 FOXD4	5.24e-06	1459	120	24	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX4 PRRX1 FOXQ1 FOXN4 HDX NPAS3 POU2F1 GBX1 KCNIP3 CASZ1 MSGN1 CREBRF ZNF18 OLIG3 ZSCAN10 GLI2 GLI3 ZNF358 ZFHX2 EN1 NEUROG2 LRRFIP1 FOXD4	1.00e-05	1412	120	23	GO:0000981
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX4 PRRX1 FOXQ1 FOXN4 HDX NSD1 POU2F1 KCNIP3 MSGN1 ZNF18 OLIG3 ZSCAN10 GLI2 GLI3 ZNF358 ZFHX2 EN1 NEUROG2 LRRFIP1 FOXD4	6.72e-05	1271	120	20	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX4 PRRX1 FOXQ1 HDX NSD1 POU2F1 KCNIP3 MSGN1 ZNF18 OLIG3 ZSCAN10 GLI2 GLI3 ZNF358 ZFHX2 EN1 NEUROG2 LRRFIP1 FOXD4	1.54e-04	1244	120	19	GO:0000978
GeneOntologyMolecularFunction	calcium, potassium:sodium antiporter activity	SLC24A2 SLC24A1	3.54e-04	5	120	2	GO:0008273
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	TRPM4 SLC5A10 MFSD2A SLC41A3 SLC24A2 SLC24A1	5.90e-04	171	120	6	GO:0015081
GeneOntologyBiologicalProcess	neuron fate commitment	PRRX1 FOXN4 GBX1 CASZ1 OLIG3 GLI2 GLI3	1.02e-06	91	120	7	GO:0048663
GeneOntologyBiologicalProcess	ventral spinal cord development	FOXN4 GBX1 OLIG3 GLI2 GLI3	2.02e-05	57	120	5	GO:0021517
GeneOntologyBiologicalProcess	spinal cord motor neuron cell fate specification	OLIG3 GLI2 GLI3	3.06e-05	11	120	3	GO:0021520
GeneOntologyBiologicalProcess	cell differentiation in spinal cord	FOXN4 GBX1 OLIG3 GLI2 GLI3	3.29e-05	63	120	5	GO:0021515
GeneOntologyBiologicalProcess	ventral spinal cord interneuron fate commitment	FOXN4 GLI2 GLI3	4.07e-05	12	120	3	GO:0060579
GeneOntologyBiologicalProcess	cell fate commitment involved in pattern specification	FOXN4 GLI2 GLI3	4.07e-05	12	120	3	GO:0060581
GeneOntologyBiologicalProcess	ventral spinal cord interneuron differentiation	FOXN4 GLI2 GLI3	6.67e-05	14	120	3	GO:0021514
GeneOntologyBiologicalProcess	spinal cord development	SOX4 FOXN4 GBX1 OLIG3 GLI2 GLI3	6.95e-05	119	120	6	GO:0021510
GeneOntologyBiologicalProcess	sensory organ development	SOX4 PRRX1 FOXN4 POU2F1 PDZD7 CASZ1 MFSD2A OLIG3 CCM2 GLI2 GLI3 RP1L1 DCHS1 NEUROG2	8.93e-05	730	120	14	GO:0007423
GeneOntologyBiologicalProcess	spinal cord motor neuron differentiation	GBX1 OLIG3 GLI2 GLI3	9.34e-05	41	120	4	GO:0021522
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord interneuron specification	GLI2 GLI3	1.00e-04	3	120	2	GO:0021775
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	GLI2 GLI3	1.00e-04	3	120	2	GO:0021776
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord patterning	GLI2 GLI3	1.00e-04	3	120	2	GO:0021910
GeneOntologyBiologicalProcess	sensory organ morphogenesis	SOX4 PRRX1 FOXN4 POU2F1 PDZD7 CASZ1 MFSD2A GLI2 GLI3	1.81e-04	343	120	9	GO:0090596
GeneOntologyBiologicalProcess	neural tube development	TRIM71 TSC2 GLI2 GLI3 ZNF358 DCHS1 EN1	1.82e-04	202	120	7	GO:0021915
GeneOntologyBiologicalProcess	spinal cord dorsal/ventral patterning	FOXN4 GLI2 GLI3	2.04e-04	20	120	3	GO:0021513
GeneOntologyBiologicalProcess	developmental growth	AKAP6 AMH DISC1 INTS1 OSTN ARHGAP4 MFSD2A CCM2 BMP10 TRIM28 GLI2 GLI3 SMPD3 EN1 RAI1	2.64e-04	911	120	15	GO:0048589
GeneOntologyBiologicalProcess	embryonic morphogenesis	PRRX1 FOXN4 NSD1 POU2F1 TRIM71 TSC2 PDZD7 MSGN1 TRIM28 GLI2 GLI3 ZNF358 EN1	2.64e-04	713	120	13	GO:0048598
GeneOntologyBiologicalProcess	spinal cord patterning	FOXN4 GLI2 GLI3	2.73e-04	22	120	3	GO:0021511
GeneOntologyBiologicalProcess	central nervous system neuron differentiation	FOXN4 DISC1 GBX1 OLIG3 GLI2 GLI3 NEUROG2	2.82e-04	217	120	7	GO:0021953
GeneOntologyBiologicalProcess	tissue morphogenesis	FOXQ1 FOXN4 TRIM71 TSC2 MSGN1 CCM2 BMP10 TRIM28 GLI2 GLI3 DCHS1 ASTN2 AJUBA	4.28e-04	750	120	13	GO:0048729
GeneOntologyCellularComponent	GLI-SUFU complex	GLI2 GLI3	1.98e-04	4	121	2	GO:1990788
GeneOntologyCellularComponent	P-body	UBAP2 TNRC6B TRIM71 EDC4 AJUBA	3.18e-04	102	121	5	GO:0000932
MousePheno	abnormal fear/anxiety-related behavior	SOX4 DCAF8 FOXN4 DISC1 DLGAP4 TMEM151B UBQLN4 HGSNAT NPAS3 TNRC6B GBX1 KCNIP3 ELFN2 CREBRF ZFHX2 C4A C4B AJUBA RAI1 ILKAP	5.52e-06	919	99	20	MP:0002065
MousePheno	bowed radius	PRRX1 GLI2 GLI3 SMPD3	6.71e-06	18	99	4	MP:0004374
MousePheno	polyphalangy	GLI3 RECQL4 RAI1	1.18e-05	7	99	3	MP:0000413
MousePheno	abnormal hindbrain development	SOX4 NPAS3 DENND1A GLI2 GLI3 UNC5C EN1 NEUROG2	2.09e-05	164	99	8	MP:0006108
MousePheno	increased freezing behavior	SOX4 DCAF8 FOXN4 UBQLN4 C4A C4B AJUBA	3.39e-05	128	99	7	MP:0020421
MousePheno	short sternum	GLI2 GLI3 DCHS1 EN1	4.91e-05	29	99	4	MP:0004321
MousePheno	abnormal cerebellar foliation	NPAS3 GLI2 GLI3 UNC5C EN1	5.48e-05	58	99	5	MP:0000857
MousePheno	abnormal cerebellum development	NPAS3 GLI2 GLI3 UNC5C EN1 NEUROG2	6.00e-05	96	99	6	MP:0000854
MousePheno	abnormal cerebellum lobule morphology	NPAS3 GLI2 GLI3 UNC5C EN1	1.26e-04	69	99	5	MP:0009964
MousePheno	abnormal freezing behavior	SOX4 DCAF8 FOXN4 UBQLN4 C4A C4B AJUBA	1.56e-04	163	99	7	MP:0020420
MousePheno	small lung	PRRX1 ADGRA2 GLI2 ACAN GLI3 DCHS1	1.64e-04	115	99	6	MP:0003641
MousePheno	lethality throughout fetal growth and development	SOX4 FOXQ1 POU2F1 TRIM71 TSC2 ADGRA2 BIRC6 CASZ1 BMP10 TACC3 RAI1	2.51e-04	435	99	11	MP:0006208
MousePheno	bowed tibia	PRRX1 GLI3 SMPD3	2.60e-04	18	99	3	MP:0004358
MousePheno	abnormal neural tube morphology	SOX4 PRRX1 TRIM71 TSC2 ADGRA2 DENND1A MSGN1 ZNRF3 TRIM28 GLI2 GLI3 DCHS1 EN1	2.65e-04	591	99	13	MP:0002151
MousePheno	abnormal trachea morphology	SOX4 MCIDAS NPAS3 GLI2 ACAN	2.69e-04	81	99	5	MP:0002282
MousePheno	enlarged cerebral aqueduct	NPAS3 GLI3	2.95e-04	4	99	2	MP:0031442
MousePheno	increased inferior colliculus size	UNC5C EN1	2.95e-04	4	99	2	MP:0000777
MousePheno	short ulna	PRRX1 GLI2 GLI3 SMPD3	3.07e-04	46	99	4	MP:0004359
MousePheno	decreased ulna size	PRRX1 GLI2 GLI3 SMPD3	3.07e-04	46	99	4	MP:0030900
MousePheno	abnormal neural tube closure	SOX4 PRRX1 TRIM71 TSC2 DENND1A MSGN1 ZNRF3 TRIM28 GLI2 GLI3	3.40e-04	378	99	10	MP:0003720
MousePheno	abnormal inferior colliculus morphology	GLI3 UNC5C EN1	3.60e-04	20	99	3	MP:0000776
MousePheno	reduced cerebellar foliation	GLI2 GLI3 UNC5C	3.60e-04	20	99	3	MP:0009719
MousePheno	short fibula	PRRX1 GLI2 GLI3	3.60e-04	20	99	3	MP:0002765
MousePheno	short humerus	GLI2 ACAN GLI3 SMPD3	3.63e-04	48	99	4	MP:0004351
MousePheno	abnormal nervous system development	SOX4 PRRX1 FOXQ1 MCIDAS NPAS3 TRIM71 TSC2 UBN2 ADGRA2 DENND1A MSGN1 OLIG3 ZNRF3 TRIM28 GLI2 GLI3 UNC5C DCHS1 EN1 NEUROG2	4.45e-04	1257	99	20	MP:0003861
MousePheno	abnormal fibula morphology	PRRX1 GLI2 GLI3 SMPD3	4.58e-04	51	99	4	MP:0002187
MousePheno	abnormal right lung accessory lobe morphology	GLI2 GLI3	4.90e-04	5	99	2	MP:0009571
MousePheno	increased forebrain size	DENND1A GLI3	4.90e-04	5	99	2	MP:0012139
MousePheno	abnormal eccrine sweat gland morphology	EDA EN1	4.90e-04	5	99	2	MP:0000675
MousePheno	abnormal brain development	SOX4 FOXQ1 MCIDAS NPAS3 TRIM71 ADGRA2 DENND1A OLIG3 GLI2 GLI3 UNC5C EN1 NEUROG2	5.50e-04	638	99	13	MP:0000913
MousePheno	lethality throughout fetal growth and development, complete penetrance	SOX4 POU2F1 TRIM71 TSC2 ADGRA2 CASZ1 BMP10 TACC3	5.52e-04	263	99	8	MP:0011099
MousePheno	abnormal facial morphology	PRRX1 FOXN4 TRIM71 UBN2 ADGRA2 EDA VWDE CCM2 MIDN GLI2 ACAN GLI3 RECQL4 SMPD3 TACC3 RAI1	6.24e-04	910	99	16	MP:0003743
MousePheno	abnormal limb long bone morphology	PRRX1 HGSNAT KCNIP3 ZSCAN10 GLI2 ACAN GLI3 RECQL4 BSCL2 SMPD3 EN1 RAI1	6.63e-04	568	99	12	MP:0011504
MousePheno	abnormal midbrain morphology	NPAS3 TRIM71 DENND1A GLI3 UNC5C EN1	7.06e-04	151	99	6	MP:0000897
MousePheno	short tibia	PRRX1 HGSNAT KCNIP3 ZSCAN10 GLI2 ACAN GLI3 BSCL2	7.22e-04	274	99	8	MP:0002764
Domain	Anaphylatoxin_comp_syst	C4A C4B	3.84e-04	5	117	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	3.84e-04	5	117	2	IPR001840
Domain	K/Na/Ca-exchanger	SLC24A2 SLC24A1	3.84e-04	5	117	2	IPR004481
Domain	ANATO	C4A C4B	8.00e-04	7	117	2	SM00104
Domain	ANATO	C4A C4B	8.00e-04	7	117	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	8.00e-04	7	117	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	8.00e-04	7	117	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	8.00e-04	7	117	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	1.06e-03	8	117	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.06e-03	8	117	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	1.06e-03	8	117	2	IPR019742
Domain	NaCa_Exmemb	SLC24A2 SLC24A1	1.36e-03	9	117	2	IPR004837
Domain	Na_Ca_ex	SLC24A2 SLC24A1	1.36e-03	9	117	2	PF01699
Domain	A2M_N	C4A C4B	1.69e-03	10	117	2	PF01835
Domain	A2M_N	C4A C4B	1.69e-03	10	117	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.69e-03	10	117	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.69e-03	10	117	2	PS00477
Domain	A2M	C4A C4B	1.69e-03	10	117	2	PF00207
Domain	A2M_N_2	C4A C4B	1.69e-03	10	117	2	IPR011625
Domain	A2M_comp	C4A C4B	1.69e-03	10	117	2	IPR011626
Domain	A2M_N_2	C4A C4B	1.69e-03	10	117	2	PF07703
Domain	A2M_recep	C4A C4B	1.69e-03	10	117	2	PF07677
Domain	A2M_comp	C4A C4B	1.69e-03	10	117	2	PF07678
Domain	Macroglobln_a2	C4A C4B	1.69e-03	10	117	2	IPR001599
Domain	TF_fork_head_CS_2	FOXQ1 FOXN4 FOXD4	2.99e-03	46	117	3	IPR030456
Domain	TF_fork_head_CS_1	FOXQ1 FOXN4 FOXD4	3.18e-03	47	117	3	IPR018122
Domain	Homeobox	PRRX1 HDX POU2F1 GBX1 ZFHX2 EN1	3.57e-03	234	117	6	PF00046
Domain	FH	FOXQ1 FOXN4 FOXD4	3.58e-03	49	117	3	SM00339
Domain	FORK_HEAD_1	FOXQ1 FOXN4 FOXD4	3.58e-03	49	117	3	PS00657
Domain	FORK_HEAD_2	FOXQ1 FOXN4 FOXD4	3.58e-03	49	117	3	PS00658
Domain	Fork_head_dom	FOXQ1 FOXN4 FOXD4	3.58e-03	49	117	3	IPR001766
Domain	FORK_HEAD_3	FOXQ1 FOXN4 FOXD4	3.58e-03	49	117	3	PS50039
Domain	Forkhead	FOXQ1 FOXN4 FOXD4	3.58e-03	49	117	3	PF00250
Domain	HOMEOBOX_1	PRRX1 HDX POU2F1 GBX1 ZFHX2 EN1	3.73e-03	236	117	6	PS00027
Domain	HOX	PRRX1 HDX POU2F1 GBX1 ZFHX2 EN1	3.80e-03	237	117	6	SM00389
Domain	HOMEOBOX_2	PRRX1 HDX POU2F1 GBX1 ZFHX2 EN1	3.96e-03	239	117	6	PS50071
Domain	Homeobox_dom	PRRX1 HDX POU2F1 GBX1 ZFHX2 EN1	3.96e-03	239	117	6	IPR001356
Domain	-	NPAS3 MSGN1 OLIG3 NEUROG2	4.91e-03	109	117	4	4.10.280.10
Domain	C345C	C4A C4B	4.98e-03	17	117	2	SM00643
Domain	TNF_1	TNFSF9 EDA	4.98e-03	17	117	2	PS00251
Domain	HLH	NPAS3 MSGN1 OLIG3 NEUROG2	5.24e-03	111	117	4	PF00010
Domain	TNF	TNFSF9 EDA	5.58e-03	18	117	2	SM00207
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	5.58e-03	18	117	2	IPR008930
Domain	HLH	NPAS3 MSGN1 OLIG3 NEUROG2	6.11e-03	116	117	4	SM00353
Domain	TNF	TNFSF9 EDA	6.21e-03	19	117	2	PF00229
Domain	TNF_dom	TNFSF9 EDA	6.21e-03	19	117	2	IPR006052
Domain	NTR	C4A C4B	6.21e-03	19	117	2	PF01759
Domain	TNF_2	TNFSF9 EDA	6.21e-03	19	117	2	PS50049
Domain	Netrin_module_non-TIMP	C4A C4B	6.21e-03	19	117	2	IPR018933
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SOX4 TRPM4 MEX3D INTS1 HECTD4 NSD1 TSC2 SFI1 GRIN2D EDC4 ADGRA2 BIRC6 DENND1A CASZ1 NADSYN1 PWWP2B AATK ZNRF3 TRIM28 KANK3 ARHGAP33 RAI1	3.51e-11	1105	121	22	35748872
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX4 PRRX1 FOXQ1 FOXN4 HDX NPAS3 POU2F1 GBX1 MSGN1 CREBRF OLIG3 GLI2 GLI3 ZFHX2 EN1 NEUROG2 FOXD4	1.83e-08	908	121	17	19274049
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI2 GLI3 EN1	1.64e-07	4	121	3	9027508
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	SOX4 PRRX1 FOXN4 NPAS3 POU2F1 BIRC6 OLIG3 TRIM28 GLI2 GLI3 ZNF358 ZFHX2 TACC3 FOXD4	1.92e-07	709	121	14	22988430
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	UBAP2 DLGAP4 HECTD4 NSD1 TNRC6B TSC2 GRIN2D EDC4 UBN2 STOX2 TRIM28 ATF7IP DCHS1 TACC3 RAI1 LRRFIP1	2.50e-07	963	121	16	28671696
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 CERK ZNF609 UBAP2 HECTD4 SFI1 ADGRA2 ARHGAP4 STOX2 AMOTL2 RAI1	2.57e-06	529	121	11	14621295
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZNF609 UBAP2 AFTPH DISC1 TMEM151B ZNF469 AATK GLI2 AJUBA LRRFIP1	2.81e-06	430	121	10	35044719
Pubmed	Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1.	GLI2 GLI3 EN1	4.84e-06	10	121	3	9247260
Pubmed	Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo.	GLI2 GLI3 EN1	8.83e-06	12	121	3	21337666
Pubmed	Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity.	GLI2 GLI3 EN1	1.15e-05	13	121	3	21093585
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.20e-05	2	121	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.20e-05	2	121	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.20e-05	2	121	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.20e-05	2	121	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.20e-05	2	121	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.20e-05	2	121	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.20e-05	2	121	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.20e-05	2	121	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.20e-05	2	121	2	19933335
Pubmed	TACC3-TSC2 maintains nuclear envelope structure and controls cell division.	TSC2 TACC3	1.20e-05	2	121	2	20237422
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.20e-05	2	121	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.20e-05	2	121	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.20e-05	2	121	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.20e-05	2	121	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.20e-05	2	121	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.20e-05	2	121	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.20e-05	2	121	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.20e-05	2	121	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.20e-05	2	121	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.20e-05	2	121	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.20e-05	2	121	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.20e-05	2	121	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.20e-05	2	121	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.20e-05	2	121	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.20e-05	2	121	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.20e-05	2	121	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.20e-05	2	121	2	11726230
Pubmed	Normal exon copy number of the GLI2 and GLI3 genes in patients with esophageal atresia.	GLI2 GLI3	1.20e-05	2	121	2	23442119
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.20e-05	2	121	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.20e-05	2	121	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.20e-05	2	121	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.20e-05	2	121	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.20e-05	2	121	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.20e-05	2	121	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.20e-05	2	121	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.20e-05	2	121	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.20e-05	2	121	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.20e-05	2	121	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.20e-05	2	121	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.20e-05	2	121	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.20e-05	2	121	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.20e-05	2	121	2	3167981
Pubmed	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome.	GLI2 GLI3	1.20e-05	2	121	2	17283082
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.20e-05	2	121	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.20e-05	2	121	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.20e-05	2	121	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.20e-05	2	121	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.20e-05	2	121	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.20e-05	2	121	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.20e-05	2	121	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.20e-05	2	121	2	22151770
Pubmed	Azilsartan prevented AGE-induced inflammatory response and degradation of aggrecan in human chondrocytes through inhibition of Sox4.	SOX4 ACAN	1.20e-05	2	121	2	34051020
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.20e-05	2	121	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.20e-05	2	121	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.20e-05	2	121	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.20e-05	2	121	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.20e-05	2	121	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.20e-05	2	121	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.20e-05	2	121	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.20e-05	2	121	2	6149581
Pubmed	New mouse models of congenital anorectal malformations.	GLI2 GLI3	1.20e-05	2	121	2	10693670
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.20e-05	2	121	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.20e-05	2	121	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.20e-05	2	121	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.20e-05	2	121	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	1.20e-05	2	121	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	1.20e-05	2	121	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	1.20e-05	2	121	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	1.20e-05	2	121	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.20e-05	2	121	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	1.20e-05	2	121	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.20e-05	2	121	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	1.20e-05	2	121	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.20e-05	2	121	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	1.20e-05	2	121	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.20e-05	2	121	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	1.20e-05	2	121	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	1.20e-05	2	121	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	1.20e-05	2	121	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.20e-05	2	121	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.20e-05	2	121	2	17971229
Pubmed	Adult Gli2+/-;Gli3Δ699/+ Male and Female Mice Display a Spectrum of Genital Malformation.	GLI2 GLI3	1.20e-05	2	121	2	27814383
Pubmed	Linkage relations of dumpy, a recessive mutant on chromosome 13 of the mouse.	FOXQ1 GLI3	1.20e-05	2	121	2	7328306
Pubmed	SOX4-induced upregulation of ARHGAP9 promotes the progression of acute myeloid leukemia.	SOX4 ARHGAP9	1.20e-05	2	121	2	34159626
Pubmed	Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors.	SLC24A2 SLC24A1	1.20e-05	2	121	2	10662833
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.20e-05	2	121	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	1.20e-05	2	121	2	3944109
Pubmed	Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo.	GLI2 GLI3	1.20e-05	2	121	2	29967343
Pubmed	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.	GLI2 GLI3	1.20e-05	2	121	2	20154143
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.20e-05	2	121	2	17921792
Interaction	SUFU interactions	DISC1 HDX ARHGAP9 SLC41A3 GLI2 GLI3 LRRC36	3.52e-06	106	121	7	int:SUFU
Interaction	TOP3B interactions	SOX4 TRPM4 UBAP2 MEX3D INTS1 HECTD4 NSD1 TNRC6B TSC2 SFI1 GRIN2D EDC4 ADGRA2 BIRC6 DENND1A CASZ1 NADSYN1 PWWP2B AATK ZNRF3 TRIM28 KANK3 ARHGAP33 RAI1	5.91e-06	1470	121	24	int:TOP3B
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	7.17e-04	9	82	2	1234
GeneFamily	Forkhead boxes	FOXQ1 FOXN4 FOXD4	9.74e-04	43	82	3	508
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	TSC2 SFI1 ELFN2 AATK TRIM28	1.39e-03	181	82	5	694
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP9 ARHGAP4 ARHGAP33	1.51e-03	50	82	3	721
GeneFamily	CD molecules\|Endogenous ligands\|Tumor necrosis factor superfamily\|Death inducing signaling complex	TNFSF9 EDA	2.97e-03	18	82	2	781
GeneFamily	PWWP domain containing	NSD1 PWWP2B	4.43e-03	22	82	2	1147
GeneFamily	POU class homeoboxes and pseudogenes	HDX POU2F1	4.83e-03	23	82	2	523
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF609 CASZ1 ZNF18 ZNF469 ZSCAN10 GLI2 GLI3 ZNF358 ZFHX2	5.16e-03	718	82	9	28
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	FOXQ1 SFI1 CASZ1 GJA3 SLC24A2 ACAN FGF5 NEUROG2 FOXD4	5.96e-07	210	121	9	M2010
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	FOXQ1 SFI1 CASZ1 GJA3 SLC24A2 ACAN FGF5 NEUROG2 FOXD4	7.84e-07	217	121	9	MM861
Coexpression	ESC_V6.5_UP_EARLY.V1_UP	FOXQ1 SGTB TNRC6B BMP10 FGF5 MAST3 RAI1	1.24e-05	166	121	7	M2770
Coexpression	GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS	COL15A1 FOXQ1 SGTB NPAS3 ADGRA2 STOX2 GLI3 KANK3 UNC5C SNX18 DCHS1	2.31e-05	505	121	11	M39167
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LURAP1 COL15A1 PMEL VWDE PTPRCAP TACC3 ARHGAP33	2.09e-07	153	121	7	c4dcdcaa672929c1da870e9fb8ada1bb030ad12f
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR31 NPAS3 RTKN EDA STOX2 AATK SMPD3	8.11e-07	187	121	7	8e8b147258982b359447add5027318f5b6d51963
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	TMEM151B HECTD4 NPAS3 TNRC6B MIDN SMPD3 MAST3	1.27e-06	200	121	7	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DISC1 PMEL ZNF469 ACAN EN1	4.74e-06	90	121	5	a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DISC1 PMEL ZNF469 ACAN EN1	4.74e-06	90	121	5	ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 TTF2 UBQLN4 TRIM71 POLR1G TACC3	5.62e-06	163	121	6	360cd65decda24853124f33a174f5224d7f3ce23
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 TTF2 UBQLN4 TRIM71 POLR1G TACC3	5.62e-06	163	121	6	b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TTF2 INTS1 RECQL4 SNX18 FAM229B MAST3	7.15e-06	170	121	6	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 PCDHB10 ADGRA2 ZFHX2 SMPD3 AJUBA	1.09e-05	183	121	6	b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTF2 WDR31 RTKN OLIG3 RECQL4 TACC3	1.12e-05	184	121	6	b998803180322a5ea2b567928dea531c26816c3c
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2\|TCGA-Kidney / Sample_Type by Project: Shred V9	PRRX1 COL15A1 ADGRA2 GLI2 ACAN DCHS1	1.19e-05	186	121	6	1e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-chondrocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PRRX1 COL15A1 NPAS3 GLI2 ACAN UNC5C	1.27e-05	188	121	6	c9270517e6940e9793586f67f02431210552f278
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 GBX1 ADGRA2 GLI2 ACAN UNC5C	1.43e-05	192	121	6	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 GBX1 ADGRA2 GLI2 ACAN UNC5C	1.43e-05	192	121	6	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	TCGA-Colorectal-Primary_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SOX4 FOXQ1 GRIN2D POLR1G RTKN AJUBA	1.75e-05	199	121	6	c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SOX4 FOXQ1 GRIN2D POLR1G RTKN AJUBA	1.75e-05	199	121	6	85b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell	NS-critical-d_07-13-Epithelial-unknown_epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SOX4 TRPM4 FOXQ1 TNFSF9 HECTD4	4.18e-05	141	121	5	33ad925ff7be3c682741a6328216a89f9d4033e9
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SOX4 PCDHB10 PMEL MFSD2A ZNF469	5.61e-05	150	121	5	70ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	OSTN PDZD7 SLC24A2 KANK3 ARHGAP33	7.39e-05	159	121	5	c960df9e4fa980401941866b5081facac4590b4d
ToppCell	normal_Lymph_Node-B_lymphocytes-Undetermined\|normal_Lymph_Node / Location, Cell class and cell subclass	NPAS3 CCDC187 ATF7IP EN1 LRRFIP1	8.08e-05	162	121	5	91ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF469 PTPRCAP SMPD3 SLC24A1 LRRC36	9.06e-05	166	121	5	c8a7d94ed762e5e045ab5f74eef691ddc5f74993
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	PRRX1 COL15A1 ADGRA2 ZNF469 UNC5C	9.59e-05	168	121	5	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	343B-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SOX4 TNFSF9 RTKN SMPD3 LRRC36	9.86e-05	169	121	5	632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P2-Tnr\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SOX4 PCDHB10 PMEL ZNF469	1.06e-04	90	121	4	6adc78899a08d48da8ed4618ecf866c9ed9be059
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SOX4 PCDHB10 PMEL ZNF469	1.06e-04	90	121	4	a74f8172780adc1410e36e2718412010ee0ebf1f
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SOX4 PCDHB10 PMEL ZNF469	1.06e-04	90	121	4	909ad62d175b657d8e541b0981ce8fed0ba7ed6c
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P2\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SOX4 PCDHB10 PMEL ZNF469	1.06e-04	90	121	4	936c5078677ec934f3049d8aa5a14d930aa2e6dc
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	LURAP1 COL15A1 CREG1 EDA RECQL4	1.16e-04	175	121	5	7de1023161233b64f11e130881c742f4cf2bff65
ToppCell	343B-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	SOX4 NRDE2 TNFSF9 SMPD3 LRRC36	1.16e-04	175	121	5	b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 GBX1 GLI2 ACAN UNC5C	1.16e-04	175	121	5	d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 GBX1 GLI2 ACAN UNC5C	1.16e-04	175	121	5	454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	AKAP6 TNRC6B POU2F1 KCNIP3 ELFN2	1.22e-04	177	121	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRX1 HDX SYT15 AATK KANK3	1.26e-04	178	121	5	6bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCell	NS-moderate-d_16-33-Lymphoid-NK\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PRRX1 COL15A1 PMEL ADGRA2 DCHS1	1.39e-04	182	121	5	fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLGAP4 PMEL ZNF358 RECQL4 RAI1	1.43e-04	183	121	5	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 PMEL KCNIP3 ELFN2 ACAN	1.47e-04	184	121	5	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 PMEL KCNIP3 ELFN2 ACAN	1.47e-04	184	121	5	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Ptgfr_(Postsubiculum)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	WDR31 OSTN DNAAF8 C4A	1.48e-04	98	121	4	9865a9de11dea6db0b75dd04fee523cd2da44766
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AKAP6 DISC1 NPAS3 EDA DENND1A	1.51e-04	185	121	5	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 ADGRA2 GLI2 ACAN UNC5C	1.62e-04	188	121	5	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AKAP6 SOX4 STOX2 ATF7IP ZFHX2	1.62e-04	188	121	5	e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SOX4 COL15A1 DLGAP4 ZNF469 AMOTL2	1.62e-04	188	121	5	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	Mesenchymal-chondrocyte\|World / Lineage, Cell type, age group and donor	PRRX1 COL15A1 NPAS3 ACAN UNC5C	1.62e-04	188	121	5	7b1e3f8a941eaa68e89c562129a92314642eec66
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 ADGRA2 GLI2 GLI3 UNC5C	1.66e-04	189	121	5	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 ADGRA2 GLI2 GLI3 UNC5C	1.66e-04	189	121	5	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 GBX1 GLI2 ACAN UNC5C	1.66e-04	189	121	5	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 GBX1 GLI2 ACAN UNC5C	1.66e-04	189	121	5	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AKAP6 DISC1 NPAS3 EDA DENND1A	1.70e-04	190	121	5	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 ADGRA2 GLI2 ACAN UNC5C	1.70e-04	190	121	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	COVID-19-kidney-vSMC/Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	AKAP6 ADGRA2 GLI2 ACAN UNC5C	1.75e-04	191	121	5	fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 ADGRA2 GLI2 UNC5C	1.75e-04	191	121	5	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 ADGRA2 GLI2 ACAN UNC5C	1.75e-04	191	121	5	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 ADGRA2 GLI2 UNC5C	1.75e-04	191	121	5	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 ADGRA2 GLI2 GLI3	1.79e-04	192	121	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRRX1 COL15A1 GLI2 GLI3 UNC5C	1.79e-04	192	121	5	67e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SOX4 PRRX1 COL15A1 NPAS3 ACAN	1.79e-04	192	121	5	d0649410cf5eacdb0c1dce70e37c7473ef5fddfa
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTKN SLC24A2 SMPD3 ARHGAP33 MAST3	1.83e-04	193	121	5	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRX1 COL15A1 ADGRA2 C4B EN1	1.83e-04	193	121	5	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 ADGRA2 GLI2 GLI3 UNC5C	1.83e-04	193	121	5	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRX1 COL15A1 ADGRA2 C4B EN1	1.83e-04	193	121	5	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	Immune-interstitial_macrophage_(C1Q_positive)\|World / Lineage, Cell type, age group and donor	DISC1 NPAS3 CREG1 EDA DENND1A	1.83e-04	193	121	5	64d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRRX1 FOXN4 KCNIP3 ZSCAN10 ACAN	1.83e-04	193	121	5	e5016959f24370579a8770787e96869f264cf7b3
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRX1 COL15A1 ADGRA2 C4B EN1	1.83e-04	193	121	5	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 GLI2 GLI3 UNC5C	1.88e-04	194	121	5	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 GLI2 GLI3 UNC5C	1.88e-04	194	121	5	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 ADGRA2 GLI2 UNC5C	1.92e-04	195	121	5	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	CERK KCNIP3 ZNF469 GLI3 AJUBA	1.92e-04	195	121	5	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 GLI2 ACAN UNC5C	1.97e-04	196	121	5	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	PRRX1 COL15A1 GLI2 UNC5C TACC3	1.97e-04	196	121	5	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNIP3 RTKN ELFN2 SLC24A2 ACAN	1.97e-04	196	121	5	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNIP3 RTKN ELFN2 SLC24A2 ACAN	1.97e-04	196	121	5	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 COL15A1 GLI2 ACAN UNC5C	1.97e-04	196	121	5	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 ADGRA2 ZFHX2 SMPD3 AJUBA	1.97e-04	196	121	5	dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	PRRX1 COL15A1 ADGRA2 SLC24A2 GLI2	1.97e-04	196	121	5	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	droplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HGSNAT UBN2 DCHS1 RAI1	2.00e-04	106	121	4	ede8407ad253080d1fa2a6e2aacf549ce220309a
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	PRRX1 COL15A1 GLI2 GLI3 UNC5C	2.02e-04	197	121	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	COL15A1 ADGRA2 MFSD2A KANK3 DCHS1	2.06e-04	198	121	5	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	18-Airway\|18 / Age, Tissue, Lineage and Cell class	PRRX1 COL15A1 TNRC6B MIDN ACAN	2.06e-04	198	121	5	3cdfcc6445858c3c54058bbd90b20b88b1771cca
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL15A1 HDX NPAS3 ZNF18 ACAN	2.06e-04	198	121	5	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PCDHA12 VWDE ZFHX2 ASTN2 SMPD3	2.06e-04	198	121	5	d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PRRX1 ACAN GLI3 UNC5C AMOTL2	2.06e-04	198	121	5	bc9c9f2c87282b5ef8514773e065d2a6b5dde338
ToppCell	metastatic_Brain-Endothelial_cells-Tumor_ECs\|metastatic_Brain / Location, Cell class and cell subclass	COL15A1 ADGRA2 MFSD2A KANK3 DCHS1	2.06e-04	198	121	5	5e274f29cc796dae7d64d6035e904816c25f9914
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PRRX1 ACAN UNC5C SMPD3 AMOTL2	2.11e-04	199	121	5	d65ee89d5c7e8ed693d58e6a6de09565840e11c5
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF609 TNRC6B BIRC6 DENND1A NBAS	2.11e-04	199	121	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FOXQ1 ADGRA2 MFSD2A KANK3 LRRC36	2.11e-04	199	121	5	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DCAF8 ADGRA2 MFSD2A KANK3 LRRC36	2.11e-04	199	121	5	0602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PRRX1 ACAN UNC5C SMPD3 AMOTL2	2.11e-04	199	121	5	bf138cc692df727e087d140c014149ee5da00d9d
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRRX1 NPAS3 ACAN RECQL4 UNC5C	2.11e-04	199	121	5	abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell	Severe-B_intermediate-0\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TNFSF9 TNRC6B MIDN PWWP2B LRRFIP1	2.16e-04	200	121	5	da37ca52b0121ab0fb6ae69626de51350e979a6a
ToppCell	(09)_Ionocytes-(3)_72hpi\|(09)_Ionocytes / shred by cell type and Timepoint	CERK ZNF609 UBAP2 ZFHX2	2.31e-04	110	121	4	fce7d5a0617fc664b657f5bb9abb290e7cc234cb
Drug	Oxamniquine [21738-42-1]; Up 200; 14.4uM; MCF7; HT_HG-U133A	TRPM4 ZNF609 DLGAP4 SFI1 EDA ARHGAP4 AATK PTPRCAP EN1	9.51e-07	195	120	9	4124_UP
Drug	celastrol; Down 200; 2.5uM; MCF7; HT_HG-U133A_EA	SOX4 CERK DCAF8 DLGAP4 SFI1 POLR1G SLC41A3 SLC24A1	6.84e-06	187	120	8	887_DN
Drug	Dipyrone [5907-38-0]; Up 200; 12uM; MCF7; HT_HG-U133A	SFI1 ADGRA2 ARHGAP4 FGF5 SLC24A1 EN1 NEUROG2 RAI1	1.04e-05	198	120	8	3929_UP
Disease	mean arterial pressure, alcohol drinking	HECTD4 CASZ1 GLI3 RP1L1 FGF5	4.37e-05	98	116	5	EFO_0004329, EFO_0006340
Disease	1,5 anhydroglucitol measurement	SLC5A10 PCDHA12 PMEL	2.01e-04	29	116	3	EFO_0008009
Disease	Profound Mental Retardation	DISC1 NSD1 ACBD6 MFSD2A RAI1	2.28e-04	139	116	5	C0020796
Disease	Mental Retardation, Psychosocial	DISC1 NSD1 ACBD6 MFSD2A RAI1	2.28e-04	139	116	5	C0025363
Disease	Mental deficiency	DISC1 NSD1 ACBD6 MFSD2A RAI1	2.28e-04	139	116	5	C0917816
Disease	hippocampal CA3 volume	OSTN GLI3 ASTN2	3.85e-04	36	116	3	EFO_0009395
Disease	Intellectual Disability	AKAP6 SOX4 DISC1 NSD1 GRIN2D ACBD6 MFSD2A RAI1	3.98e-04	447	116	8	C3714756
Disease	body weight	AKAP6 PTBP3 HDX HECTD4 TNRC6B POLR1G SPATA31C1 DENND1A NBAS AATK SLC24A2 ACAN ASTN2 SMPD3	4.38e-04	1261	116	14	EFO_0004338
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI2 GLI3	5.42e-04	9	116	2	DOID:0050338 (implicated_via_orthology)
Disease	Holoprosencephaly sequence	PRRX1 GLI2	6.75e-04	10	116	2	cv:C0079541
Disease	PR interval	AKAP6 PRRX1 CREBRF MFSD2A ZNF469 ZNF358 FGF5 ASTN2	7.75e-04	495	116	8	EFO_0004462
Disease	coffee consumption measurement	AKAP6 NPAS3 BIRC6 PWWP2B RAI1	7.80e-04	182	116	5	EFO_0006781
Disease	cortical surface area measurement	OSTN NPAS3 TNRC6B TRIM71 ADGRA2 DENND1A ZNF469 GLI3 RP1L1 UNC5C ASTN2 TACC3 AJUBA NEUROG2	8.24e-04	1345	116	14	EFO_0010736
Disease	systolic blood pressure, alcohol consumption measurement	CASZ1 RP1L1 FGF5	8.46e-04	47	116	3	EFO_0006335, EFO_0007878
Disease	mean arterial pressure, alcohol consumption measurement	CASZ1 RP1L1 FGF5	1.14e-03	52	116	3	EFO_0006340, EFO_0007878
Disease	diastolic blood pressure, alcohol consumption measurement	HECTD4 CASZ1 FGF5	1.27e-03	54	116	3	EFO_0006336, EFO_0007878
Disease	cup-to-disc ratio measurement	ARHGAP9 TRIM71 ELFN2 CCM2 ZNRF3 GLI3 AMOTL2	1.59e-03	430	116	7	EFO_0006939
Disease	prostate carcinoma, type 2 diabetes mellitus	AKAP6 UBAP2 TNRC6B	1.64e-03	59	116	3	EFO_0001663, MONDO_0005148
Disease	systolic blood pressure, alcohol drinking	HECTD4 CASZ1 RP1L1 FGF5	1.66e-03	128	116	4	EFO_0004329, EFO_0006335
Disease	polycystic ovary syndrome	DENND1A ZNRF3 UNC5C	1.72e-03	60	116	3	EFO_0000660
Disease	age-related hearing impairment	OSTN NSD1 SFI1 CCM2 ACAN GLI3	1.81e-03	324	116	6	EFO_0005782
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	TNRC6B ASTN2	2.25e-03	18	116	2	EFO_1000649, HP_0000131
Disease	anti-Mullerian hormone measurement	AMH ZNRF3	2.78e-03	20	116	2	EFO_0004769
Disease	gait measurement	AKAP6 NPAS3 TACC3 MAST3	2.96e-03	150	116	4	EFO_0007680
Disease	neuroimaging measurement	UBAP2 OSTN TNRC6B DENND1A ZNF469 CCM2 ZNRF3 GLI3 TACC3 NEUROG2 RAI1	3.30e-03	1069	116	11	EFO_0004346
Disease	Paroxysmal atrial fibrillation	AKAP6 PRRX1 CASZ1 FGF5	3.40e-03	156	116	4	C0235480
Disease	familial atrial fibrillation	AKAP6 PRRX1 CASZ1 FGF5	3.40e-03	156	116	4	C3468561
Disease	Persistent atrial fibrillation	AKAP6 PRRX1 CASZ1 FGF5	3.40e-03	156	116	4	C2585653
Disease	axial length measurement	ADGRA2 ZNF469 ZNRF3	3.50e-03	77	116	3	EFO_0005318
Disease	atrial fibrillation	AKAP6 PRRX1 CASZ1 SLC24A2 FGF5 ASTN2	3.53e-03	371	116	6	EFO_0000275
Disease	Immunologic Deficiency Syndromes	NBAS C4A	3.67e-03	23	116	2	C0021051
Disease	Atrial Fibrillation	AKAP6 PRRX1 CASZ1 FGF5	3.72e-03	160	116	4	C0004238
Disease	Autistic Disorder	DISC1 NSD1 TSC2 ASTN2 C4B	3.77e-03	261	116	5	C0004352
Disease	lean body mass	NPAS3 NSD1 AATK ACAN GLI3 TACC3	3.92e-03	379	116	6	EFO_0004995

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSGGSPELSALRLSE	AMOTL2	536	Q9Y2J4
GGDSSIELEPGLSSS	FAM229B	16	Q4G0N7
AQSGGLEASGSLESP	CCDC187	706	A0A096LP49
SQSPTGTDDSLLGGL	BIRC6	2606	Q9NR09
LDTLGSEGALSPGGV	C4B	986	P0C0L5
GSGPLLSDSGSLLAT	ADGRA2	981	Q96PE1
GGAAGALELLSSESG	ADGRA2	1206	Q96PE1
SSPRGSLLLDGAGAG	AJUBA	136	Q96IF1
GTPSLLGAVSSGSAA	CASZ1	816	Q86V15
SGLTNPLDASGGSTL	AFTPH	811	Q6ULP2
EGPGSLAAGESSSLS	CREBRF	306	Q8IUR6
GLSAGSLSESAVGPV	CCM2	176	Q9BSQ5
LPAGAITGDSGGELS	ACBD6	6	Q9BR61
SSSSLDPSLAGCGGD	DISC1	301	Q9NRI5
LDGEAGAFRSSGPAS	DLGAP4	211	Q9Y2H0
GSPGSAGTAAESRLL	ASTN2	106	O75129
SLDAAGASLATLPGG	RAI1	1641	Q7Z5J4
SGGDSALSGELSASL	NSD1	981	Q96L73
ALSRGFGSSAPEGLE	EDC4	751	Q6P2E9
LEDGLGSSDSPGLLS	MSGN1	11	A6NI15
AGTAGAFLLEPSSGE	DCHS1	1896	Q96JQ0
SGLELPLTDGGSIGD	GLI3	726	P10071
PLTDGGSIGDLSAID	GLI3	731	P10071
ESGSLSALTPGEEAG	HDX	516	Q7Z353
LPGLSFGSEGDSDGK	TRIM71	591	Q2Q1W2
LLSPGGASAALSSSG	NEUROG2	191	Q9H2A3
AAGGSAPELFTSLIG	SLC24A1	501	O60721
ADGGSLEAVRLGPSS	INTS1	1601	Q8N201
GSEPLSSDLGSLHGL	LRRC36	496	Q1X8D7
PLGLGDLSSGSLSSL	PDZD7	11	Q9H5P4
LSLSLTGDDGGPNRT	DCAF8	46	Q5TAQ9
AFAGLSEAPDGGSSR	NRDE2	6	Q9H7Z3
ATAGLRGDTALGAPS	MEX3D	386	Q86XN8
ELGTSGALLLPGASS	LURAP1	36	Q96LR2
TGPGSLGDLTALDDT	GLI2	686	P10070
LVALGGDSNGSSSPL	AMH	56	P03971
GELSLTLTALDGGSP	PCDHB10	206	Q9UN67
TGSLGSLGSLGEPLD	HECTD4	3121	Q9Y4D8
DGDSGSLGSPSASRE	SMPD3	286	Q9NY59
VAEGSGLTSLAAPLG	FOXD4	401	Q12950
GLTSLAAPLGGEGTS	FOXD4	406	Q12950
LGAAAAATPGGLSLS	EN1	16	Q05925
SALSGGSADLGGPRD	NBAS	2046	A2RRP1
LDSRLASGGPSEGIS	GPR84	241	Q9NQS5
SSLLGSDAPPGGDLA	MCIDAS	86	D6RGH6
GGALSSGNASSPLSA	OLIG3	186	Q7RTU3
DFSGQLSGDRASGLP	ACAN	881	P16112
LSGDRASGLPSGDLD	ACAN	886	P16112
ASGLPSGDLDSSGLT	ACAN	891	P16112
ELPSGAEILEGSASG	ACAN	936	P16112
SASGVGDLSGLPSGE	ACAN	966	P16112
EISASGFGDLSGLPS	ACAN	1536	P16112
LSGLPSGREGLETSA	ACAN	1566	P16112
ISGAGEISGLPSSEL	ACAN	1686	P16112
DISGRASGLPSGTEL	ACAN	1701	P16112
GSVELSGLPSGEADL	ACAN	1851	P16112
ALASGGSLPITSLDA	POU2F1	641	P14859
GFGSPLDRLSAGSVD	OSTN	86	P61366
GAESGSAAGLLPTSI	MFSD2A	6	Q8NA29
SSPAASLGSQGSGLE	FGF5	61	P12034
SESSAAGLGALSGSP	ARHGAP33	696	O14559
TSGTLSSLGGLDPDS	EDA	86	Q92838
GSLLDVATSPAGTSG	CEFIP	1141	Q711Q0
DGFLDSSAGGPGALL	GBX1	216	Q14549
GLDSFSSGPGEEALL	BMP10	286	O95393
GLSPAAHLGDGSSDL	CERK	406	Q8TCT0
SSTDSGSGGPLLFDD	ILKAP	36	Q9H0C8
AALGDAEGASPSSLG	DNAAF8	411	Q8IYS4
QSEGGSGLDSSPFLS	COQ8B	121	Q96D53
AGDPASGVLASGDST	ATF7IP	141	Q6VMQ6
ALSLIITADDGSGGP	MAST3	901	O60307
GPGAAGTSSDALLAL	DENND1A	771	Q8TEH3
SSESLASDDGGAPGI	KANK3	91	Q6NY19
LSAALLAPGGSSGRD	HGSNAT	46	Q68CP4
ADVLSLSDGPPGAGS	CREG1	86	O75629
APLLLDGSGSSLEGS	GJA3	371	Q9Y6H8
LETLGSSEPAGGALR	BSCL2	376	Q96G97
DPITDSGSGAGAFLD	COL15A1	336	P39059
SDGSLLGDLGHTPLS	KCNIP3	11	Q9Y2W7
DGPAGGLADLSSGSS	PWWP2B	371	Q6NUJ5
LDTLGSEGALSPGGV	C4A	986	P0C0L4
PLSAAGDDSLGSDGD	FOXQ1	31	Q9C009
PGLSAATLASLGGTS	LRRFIP1	101	Q32MZ4
LATPAGSAGGAVSEL	PCDHA12	566	Q9UN75
GSPSEASGLGLDFED	MIDN	436	Q504T8
FADSPLGCDLGASGL	FOXN4	451	Q96NZ1
ASLDSAGGSGSSPIL	RTKN	231	Q9BST9
RAGPGLSTAGSLDLE	SFI1	1136	A8K8P3
DSGAGLELGIASSPT	SOX4	21	Q06945
ASELLPHTSSGGLGD	SYT15	106	Q9BQS2
TDLLGDASPAFGSGS	TACC3	126	Q9Y6A5
ASSAGGGLSPSDELL	TMEM151B	341	Q8IW70
SPSAGPLSLAEGGAE	AATK	611	Q6ZMQ8
AAGGSAPELFTSLIG	SLC24A2	181	Q9UI40
GGGLRSSESLPAAAE	RECQL4	56	O94761
PASAGGSAEALLSDL	PTPRCAP	166	Q14761
EATLLAPSTEAGGGL	POLR1G	91	O15446
LSTGGLPVASEDGAL	SLC41A3	26	Q96GZ6
RLSSASSPGGLDAGL	NPAS3	616	Q8IXF0
DLAASVPAISGLGGS	SPATA31C1	271	P0DKV0
STESITGSLGPLLDG	PMEL	446	P40967
QTAGESGSSPEGLLA	ARHGAP4	816	P98171
SSIESLSPGGDLFGL	AKAP6	1566	Q13023
LDSGPEGASVSSAGL	VWDE	1131	Q8N2E2
SLSSVLGSGFGELAP	UBAP2	351	Q5T6F2
GPGEDGSLLGSSEIL	ZSCAN10	261	Q96SZ4
LLDAASDGSPLSESG	UBN2	411	Q6ZU65
SGPAASSGLLGLATS	ZFHX2	2246	Q9C0A1
GALLGSSDTGPQSGE	RP1L1	1026	Q8IWN7
PIGASLFASSEGSGL	SLC5A10	61	A0PJK1
LGASSLGTPEDLAEG	STOX2	501	Q9P2F5
SAGPITGLLDSLSGF	TRIM51	271	Q9BSJ1
SSTVADEPGALGSGA	SNX18	161	Q96RF0
LGALSNDGSDDGPSV	ZNF609	601	O15014
LSGSGPAELSAGEDE	ARHGAP9	466	Q9BRR9
SLALSGGPSNEGTVL	PTBP3	161	O95758
SDPGLAGVSLTGGLS	TNFSF9	111	P41273
RSLGDLPGGLEGSSA	ZNF469	3181	Q96JG9
AGPSAGAAGSSTLFL	ZNRF3	721	Q9ULT6
GPAAGVGGLTDLSSL	SGTB	251	Q96EQ0
GLENSSSGPGELLSH	ZNF18	166	P17022
SLDGSGPLTSLAVGD	WDR31	321	Q8NA23
GRSLLESPGLTSGSD	PRRX1	61	P54821
GAGEGSPSATASILS	UBQLN4	146	Q9NRR5
PALALLSASGTGSAA	UNC5C	26	O95185
LAETLEDTLAPGSGG	TRPM4	311	Q8TD43
SLPGAGLSSQELSGG	TRIM28	816	Q13263
SESGTAPDSTLGGAA	TNRC6B	146	Q9UPQ9
LGLDSGELQSGPESS	TSC2	1081	P49815
APGLSLGEGREAATS	TTF2	336	Q9UNY4
DAVSVLGSGLGLSPG	ZNF358	441	Q9NW07
SFLGGGSSSGDPELA	ELFN2	561	Q5R3F8
GFLLPLSGGVDSAAT	NADSYN1	351	Q6IA69
EDSESLGGASLGGLE	GRIN2D	1116	O15399