Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

3.93e-075693GO:0030156
GeneOntologyMolecularFunctionATP-dependent activity

ATAD3B HYOU1 ATAD3C MYO7B CHD5 NAV1 DHX35 CHD3 CHD4

2.54e-04614699GO:0140657
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD5 CHD3 CHD4

2.82e-0437693GO:0140658
GeneOntologyMolecularFunctionhistone binding

PWP1 CHD5 HJURP CHD3 CHD4 SCML4

3.07e-04265696GO:0042393
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2D KMT2B

3.25e-048692GO:0140945
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SETDB1 KMT2D KMT2B

4.73e-0444693GO:0140938
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2D KMT2B

5.20e-0410692GO:0140999
GeneOntologyMolecularFunctionATP hydrolysis activity

ATAD3B ATAD3C CHD5 NAV1 DHX35 CHD3 CHD4

8.10e-04441697GO:0016887
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SETDB1 KMT2D KMT2B

1.69e-0368693GO:0016279
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

MTHFD2 PYCR3

1.74e-0318692GO:0016646
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SETDB1 KMT2D KMT2B

1.76e-0369693GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETDB1 KMT2D KMT2B

1.91e-0371693GO:0042054
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2D KMT2B

2.15e-0320692GO:0042800
GeneOntologyMolecularFunctionhelicase activity

CHD5 DHX35 CHD3 CHD4

2.19e-03158694GO:0004386
GeneOntologyCellularComponentCHD-type complex

CHD5 CHD3 CHD4

2.47e-0517713GO:0090545
GeneOntologyCellularComponentNuRD complex

CHD5 CHD3 CHD4

2.47e-0517713GO:0016581
GeneOntologyCellularComponentextrinsic component of presynaptic active zone membrane

DGKI RIMS1

3.40e-053712GO:0098891
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

1.16e-0428713GO:0002177
GeneOntologyCellularComponenthistone deacetylase complex

TRERF1 CHD5 CHD3 CHD4

2.01e-0485714GO:0000118
GeneOntologyCellularComponentmitochondrial nucleoid

ATAD3B ATAD3C FASTKD2

6.96e-0451713GO:0042645
GeneOntologyCellularComponentnucleoid

ATAD3B ATAD3C FASTKD2

6.96e-0451713GO:0009295
DomainCHDCT2

CHD5 CHD3 CHD4

5.26e-083713PF08074
DomainCHDNT

CHD5 CHD3 CHD4

5.26e-083713PF08073
DomainDUF1086

CHD5 CHD3 CHD4

5.26e-083713IPR009462
DomainDUF1087

CHD5 CHD3 CHD4

5.26e-083713IPR009463
DomainCHD_N

CHD5 CHD3 CHD4

5.26e-083713IPR012958
DomainCHD_C2

CHD5 CHD3 CHD4

5.26e-083713IPR012957
DomainDUF1087

CHD5 CHD3 CHD4

5.26e-083713PF06465
DomainDUF1086

CHD5 CHD3 CHD4

5.26e-083713PF06461
DomainDUF1087

CHD5 CHD3 CHD4

5.26e-083713SM01147
DomainDUF1086

CHD5 CHD3 CHD4

5.26e-083713SM01146
DomainDNA/RNA_helicase_DEAH_CS

CHD5 DHX35 CHD3 CHD4

9.18e-0635714IPR002464
DomainPHD

KMT2D KMT2B CHD5 CHD3 CHD4

9.66e-0675715PF00628
DomainZnf_PHD-finger

KMT2D KMT2B CHD5 CHD3 CHD4

1.25e-0579715IPR019787
DomainDEAH_ATP_HELICASE

CHD5 DHX35 CHD3 CHD4

1.28e-0538714PS00690
DomainZnf_FYVE_PHD

KMT2D KMT2B CHD5 CHD3 CHD4 RIMS1

2.02e-05147716IPR011011
DomainPHD

KMT2D KMT2B CHD5 CHD3 CHD4

2.23e-0589715SM00249
DomainZnf_PHD

KMT2D KMT2B CHD5 CHD3 CHD4

2.48e-0591715IPR001965
DomainPost-SET_dom

SETDB1 KMT2D KMT2B

2.85e-0516713IPR003616
DomainPostSET

SETDB1 KMT2D KMT2B

2.85e-0516713SM00508
DomainPOST_SET

SETDB1 KMT2D KMT2B

2.85e-0516713PS50868
DomainZF_PHD_2

KMT2D KMT2B CHD5 CHD3 CHD4

3.06e-0595715PS50016
DomainZF_PHD_1

KMT2D KMT2B CHD5 CHD3 CHD4

3.22e-0596715PS01359
DomainDUF3523

ATAD3B ATAD3C

4.26e-053712PF12037
DomainDUF3523

ATAD3B ATAD3C

4.26e-053712IPR021911
DomainChromo_domain

CHD5 CHD3 CHD4

1.01e-0424713IPR023780
DomainHMG_box_dom

KMT2D CHD5 CHD3 CHD4

1.09e-0465714IPR009071
DomainChromo

CHD5 CHD3 CHD4

1.29e-0426713PF00385
DomainFYrich_C

KMT2D KMT2B

1.41e-045712IPR003889
DomainFYrich_N

KMT2D KMT2B

1.41e-045712IPR003888
DomainFYRC

KMT2D KMT2B

1.41e-045712SM00542
DomainFYRN

KMT2D KMT2B

1.41e-045712SM00541
DomainFYRN

KMT2D KMT2B

1.41e-045712PF05964
DomainFYRC

KMT2D KMT2B

1.41e-045712PF05965
DomainFYRC

KMT2D KMT2B

1.41e-045712PS51543
DomainFYRN

KMT2D KMT2B

1.41e-045712PS51542
DomainCHROMO_1

CHD5 CHD3 CHD4

1.61e-0428713PS00598
DomainCHROMO_2

CHD5 CHD3 CHD4

1.61e-0428713PS50013
DomainSNF2_N

CHD5 CHD3 CHD4

2.41e-0432713IPR000330
DomainChromodomain-like

CHD5 CHD3 CHD4

2.41e-0432713IPR016197
DomainSNF2_N

CHD5 CHD3 CHD4

2.41e-0432713PF00176
DomainChromo/shadow_dom

CHD5 CHD3 CHD4

2.65e-0433713IPR000953
DomainCHROMO

CHD5 CHD3 CHD4

2.65e-0433713SM00298
DomainSH3_2

RIMBP3 MYO7B RIMBP3C RIMBP3B

3.22e-0486714IPR011511
DomainSH3_2

RIMBP3 MYO7B RIMBP3C RIMBP3B

3.22e-0486714PF07653
Domain-

CHST5 ATAD3B ATAD3C MYO7B CHD5 NAV1 DHX35 CHD3 CHD4 HYDIN

4.96e-0474671103.40.50.300
DomainSET

SETDB1 KMT2D KMT2B

5.06e-0441713PF00856
DomainSET

SETDB1 KMT2D KMT2B

7.11e-0446713SM00317
DomainHelicase_C

CHD5 DHX35 CHD3 CHD4

7.37e-04107714PF00271
DomainHELICc

CHD5 DHX35 CHD3 CHD4

7.37e-04107714SM00490
DomainHelicase_C

CHD5 DHX35 CHD3 CHD4

7.63e-04108714IPR001650
DomainHELICASE_CTER

CHD5 DHX35 CHD3 CHD4

7.90e-04109714PS51194
DomainHELICASE_ATP_BIND_1

CHD5 DHX35 CHD3 CHD4

7.90e-04109714PS51192
DomainDEXDc

CHD5 DHX35 CHD3 CHD4

7.90e-04109714SM00487
DomainHelicase_ATP-bd

CHD5 DHX35 CHD3 CHD4

8.17e-04110714IPR014001
DomainSET_dom

SETDB1 KMT2D KMT2B

9.08e-0450713IPR001214
DomainSET

SETDB1 KMT2D KMT2B

9.08e-0450713PS50280
Domain-

KMT2D CHD5 CHD3

1.20e-03557131.10.30.10
DomainP-loop_NTPase

CHST5 ATAD3B ATAD3C MYO7B CHD5 NAV1 DHX35 CHD3 CHD4 HYDIN

1.32e-038487110IPR027417
DomainSH3

RIMBP3 MYO7B OBSCN RIMBP3C RIMBP3B

1.38e-03216715SM00326
DomainSH3

RIMBP3 MYO7B OBSCN RIMBP3C RIMBP3B

1.38e-03216715PS50002
DomainL30e-like

MRM3 SECISBP2

1.45e-0315712IPR029064
Domain-

MRM3 SECISBP2

1.45e-03157123.30.1330.30
DomainSH3_domain

RIMBP3 MYO7B OBSCN RIMBP3C RIMBP3B

1.50e-03220715IPR001452
DomainZinc_finger_PHD-type_CS

CHD5 CHD3 CHD4

1.94e-0365713IPR019786
DomainEPHD

KMT2D KMT2B

3.13e-0322712PS51805
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B

3.27e-0378713PF14604
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRERF1 SETDB1 KMT2D KMT2B SATB1 ACACB NAV1 CHD3 CHD4 FAR1 SHTN1 CNOT1 PYCR3

4.89e-12418741334709266
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

3.69e-08474319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

9.22e-08574317855024
Pubmed

Human transcription factor protein interaction networks.

TRERF1 PWP1 SETDB1 PPP2R1A ATAD3B KMT2D TADA1 KMT2B SATB1 ACACB CHD5 HIC2 CHD3 FAR1 CNOT1

2.78e-071429741535140242
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

PPP2R1A ATAD3B HYOU1 ATAD3C ACACB MTHFD2 CHD4 FAR1 CNOT1 PYCR3

1.46e-06665741030457570
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

3.31e-061474317662146
Pubmed

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

MCPH1 CHD3 CHD4

3.31e-061474325150861
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SETDB1 ATAD3B TADA1 MAP1A MTHFD2 CHD5 HIC2 CHD3 CHD4 ZNF362 FAR1 NUFIP1

3.94e-061116741231753913
Pubmed

DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.

CHD5 CHD3 CHD4

4.13e-061574335695185
Pubmed

Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.

CHD3 CHD4

4.47e-0627427560064
Pubmed

Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.

KMT2D KMT2B

4.47e-06274235506254
Pubmed

Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).

KMT2D KMT2B

4.47e-06274235640156
Pubmed

Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.

CHD3 CHD4

4.47e-06274235568926
Pubmed

The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.

CHD3 CHD4

4.47e-0627427575689
Pubmed

Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line.

SETDB1 CHD4

4.47e-06274237970920
Pubmed

Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.

CHD3 CHD4

4.47e-0627428843877
Pubmed

p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.

SATB1 CHD3 CHD4

5.08e-061674321930775
Pubmed

A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.

CHD5 CHD3 CHD4

6.15e-061774327806305
Pubmed

Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.

KMT2D KMT2B

1.34e-05374232544095
Pubmed

The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.

CHD3 CHD4

1.34e-05374232658897
Pubmed

ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells.

ATAD3B ATAD3C

1.34e-05374238923254
Pubmed

[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].

ATAD3B ATAD3C

1.34e-05374222192748
Pubmed

The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.

KMT2D CHD3

1.34e-05374226551667
Pubmed

ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.

ATAD3B ATAD3C

1.34e-05374234936866
Pubmed

Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.

MCPH1 CHD4

1.34e-05374222219182
Pubmed

The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.

KMT2D KMT2B

1.34e-05374223358417
Pubmed

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

ATAD3B ATAD3C

1.34e-05374228549128
Pubmed

Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.

ATAD3B ATAD3C

1.34e-05374225375035
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2D KMT2B

2.67e-05474219221051
Pubmed

Characterization of the CHD family of proteins.

CHD3 CHD4

2.67e-0547429326634
Pubmed

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

ATAD3B ATAD3C

2.67e-05474235236834
Pubmed

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.

ATAD3B ATAD3C

2.67e-05474236736924
Pubmed

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

KMT2D KMT2B

2.67e-05474220808952
Pubmed

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

KMT2D KMT2B

2.67e-05474223826075
Pubmed

The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.

ATAD3B ATAD3C

2.67e-05474238250153
Pubmed

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.

ATAD3B ATAD3C

2.67e-05474229242539
Pubmed

NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.

CHD3 CHD4

2.67e-05474216574654
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2D KMT2B

2.67e-05474223129768
Pubmed

Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aα catalytic subunit.

PPP2R1A PPME1

2.67e-05474222167190
Pubmed

Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.

PPP2R1A PPME1

2.67e-05474232071079
Pubmed

PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.

SETDB1 CHD3

2.67e-05474218082607
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

KMT2D SATB1 CHD3 ZNF362

3.05e-058374428794006
Pubmed

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

PPP2R1A CHD5 CHD3 CHD4

4.39e-059174420362542
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2D KMT2B

4.45e-05574226320581
Pubmed

Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.

ATAD3B ATAD3C

4.45e-05574224239551
Pubmed

PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.

PPP2R1A PPME1

4.45e-05574219293187
Pubmed

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

PPP2R1A PPME1

4.45e-05574218596935
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2D KMT2B

4.45e-05574228609655
Pubmed

ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels.

ATAD3B ATAD3C

4.45e-05574229898916
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

PPP2R1A KMT2B SATB1 CHD3 CHD4

4.58e-0518374536129980
Pubmed

Identification of the BRD1 interaction network and its impact on mental disorder risk.

CHD5 CHD3 CHD4

5.76e-053574327142060
Pubmed

SETDB1 Modulates Degradation of Phosphorylated RB and Anticancer Efficacy of CDK4/6 Inhibitors.

SETDB1 CHD3

6.66e-05674236637424
Pubmed

MLL associates specifically with a subset of transcriptionally active target genes.

KMT2D KMT2B

6.66e-05674216199523
Pubmed

Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.

CHD3 CHD4

6.66e-05674217626165
Pubmed

Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.

ATAD3B ATAD3C

6.66e-05674231472450
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

KMT2D KMT2B

6.66e-05674224176642
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2D KMT2B

6.66e-05674217021013
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ATAD3B CDH26 MCPH1 VPS13C OBSCN NAV1 CHD3 ZNF362 RIMS1 SHTN1 CNOT1 MICU1

6.80e-051489741228611215
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

ATAD3B PKHD1 CHD3 CHD4 CNOT1

7.32e-0520274524639526
Pubmed

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

CHD5 CHD3 CHD4

7.39e-053874333283408
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

SZT2 PKHD1 RIMS1 FAR1 CNOT1

8.40e-0520874533230847
Pubmed

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.

KMT2D KMT2B

9.31e-05774223995757
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2D KMT2B

9.31e-05774230604749
Pubmed

Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.

KMT2D KMT2B

9.31e-05774216540515
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2D KMT2B

9.31e-05774219556342
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

PPP2R1A ATAD3B HYOU1 ATAD3C MTHFD2 NUTM2A PPME1 CHD4 PYCR3

1.02e-0487874937223481
Pubmed

Interaction network of human early embryonic transcription factors.

TRERF1 KMT2D KMT2B HYOU1 SATB1 ACACB

1.05e-0435174638297188
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

PWP1 KMT2D KMT2B

1.07e-044374333472061
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2D KMT2B

1.24e-04874223130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2D KMT2B

1.24e-04874222266653
Pubmed

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

ATAD3B ATAD3C

1.24e-04874230914652
Pubmed

Atad3 function is essential for early post-implantation development in the mouse.

ATAD3B ATAD3C

1.24e-04874223372768
Pubmed

Mammalian chromodomain proteins: their role in genome organisation and expression.

CHD3 CHD4

1.24e-04874210655032
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

PWP1 ATAD3B KMT2D KMT2B

1.25e-0411974423508102
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SZT2 VPS13C CHD5 HIC2 FASTKD2 CNOT1 BAHD1

1.35e-0452974714621295
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

ATAD3B HYOU1 MAP1A CHD4 FAR1 CNOT1 PYCR3

1.43e-0453474735032548
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

SETDB1 CHD3 CHD4 ZNF362

1.51e-0412574432891193
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

PPP2R1A ATAD3B HYOU1 MAP1A FER SECISBP2 DHX35 CNOT1

1.53e-0472474836232890
Pubmed

Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.

KMT2D S1PR2

1.59e-04974235296311
Pubmed

SATB1 targets chromatin remodelling to regulate genes over long distances.

SATB1 CHD3

1.59e-04974212374985
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2D KMT2B

1.59e-04974222665483
Pubmed

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

KMT2D KMT2B

1.59e-04974216951254
Pubmed

Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.

PPP2R1A PPME1

1.59e-04974224841198
Pubmed

High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays.

NAV1 FAR1 SHTN1

1.69e-045074329560723
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

KMT2B MCPH1 EBLN1 VPS13C OBSCN PKHD1 HIC2 CNOT1

1.71e-0473674829676528
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

SETDB1 NAV1 SHTN1 BAHD1

1.75e-0413074412421765
Pubmed

Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis.

KMT2B SATB1 NAV1

2.01e-045374324982181
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

TRERF1 ATAD3B ATAD3C CHD4

2.02e-0413574431077711
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PWP1 MRM3 HJURP CHD3 CHD4 FAR1 CNOT1 NUFIP1

2.10e-0475974835915203
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ATAD3B HYOU1 ATAD3C ACACB ARMC3 CHD5 PKHD1 CHD3 CHD4 RIMS1 SCML4

2.27e-041442741135575683
Pubmed

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

MAP1A CHD3 CHD4

2.36e-045674326919559
Pubmed

Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast.

ATAD3B ATAD3C

2.43e-041174236000457
Pubmed

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

CHD3 CHD4

2.43e-041174210204490
Pubmed

New nomenclature for chromatin-modifying enzymes.

SETDB1 KMT2D KMT2B

2.49e-045774318022353
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

PPP2R1A KMT2B CHD4 CNOT1

2.73e-0414674423892456
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRERF1 KMT2D CHD3 CHD4 ZNF362

2.73e-0426874533640491
Pubmed

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.

CHD3 CHD4

2.91e-041274222560079
Pubmed

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

KMT2D KMT2B

2.91e-041274217707229
Pubmed

NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.

CHD3 CHD4

2.91e-04127429885572
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2D KMT2B

2.91e-041274227563068
InteractionKDM1A interactions

TRERF1 SETDB1 KMT2D KMT2B SATB1 ACACB MCPH1 NAV1 CHD3 CHD4 FAR1 SHTN1 CNOT1 BAHD1 PYCR3

3.47e-079416715int:KDM1A
InteractionHDAC1 interactions

TRERF1 SETDB1 PPP2R1A KMT2D KMT2B SATB1 ACACB CHD5 NAV1 CHD3 CHD4 FAR1 USP37 SHTN1 BAHD1 PYCR3

4.94e-0711086716int:HDAC1
InteractionRCOR1 interactions

KMT2D KMT2B SATB1 ACACB CHD3 CHD4 FAR1 SHTN1 PYCR3

3.60e-05494679int:RCOR1
Cytoband22q11.21

RIMBP3 HIC2 RIMBP3C RIMBP3B

3.27e-0511174422q11.21
Cytoband10p12.31

EBLN1 ARMC3

5.80e-042274210p12.31
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 OR11H1 HIC2 RIMBP3C RIMBP3B

5.94e-04419745chr22q11
Cytoband18q21.1

ZBTB7C SKOR2

1.74e-033874218q21.1
CytobandEnsembl 112 genes in cytogenetic band chr18q21

ZBTB7C SKOR2 ALPK2

4.51e-03205743chr18q21
GeneFamilyPHD finger proteins

KMT2D KMT2B CHD5 CHD3 CHD4

2.85e-069045588
GeneFamilyPHD finger proteins|NuRD complex

CHD5 CHD3 CHD4

3.12e-06124531305
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETDB1 KMT2D KMT2B

8.17e-0534453487
ToppCellCiliated_cells-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

MAP1A ARMC3 RIMS1 HYDIN UBXN10

1.39e-0518474507c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

TRERF1 CDH26 ZBTB7C BAHD1

1.11e-0414974489705865e94360c1288ee98c5a6b381f3c6242b3
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TADA1 TMEM221 OBSCN KMO

1.50e-04161744ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TADA1 TMEM221 OBSCN KMO

1.50e-041617440089d7bb305c592392791862a3341fc92af8f3e2
ToppCellfacs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2B SZT2 PPME1 HIC2

1.61e-041647441d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2B SZT2 PPME1 HIC2

1.61e-04164744bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

SZT2 OBSCN CHD4 UBXN10

1.68e-0416674432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCelldroplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM221 ARMC3 CHD5 OBSCN

1.72e-041677441248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCelldroplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM221 ARMC3 CHD5 OBSCN

1.72e-04167744a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRERF1 HJURP SHTN1 MICU1

1.76e-041687444c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCelldroplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 IRAG1 SHTN1 KMO

1.80e-04169744149a4f83da15bdeb170e980fb5b5b1af89ae07a6
ToppCellfacs-Lung-EPCAM-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCPH1 SECISBP2 HIC2 CNOT1

1.84e-0417074412203d4410f38cc933d9f160b5fb76828df94119
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRERF1 IRAG1 SHTN1 KMO

1.84e-04170744bf589c4297ccc90e5f51e3d0fcc229548af4fcef
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB MAP1A RP1L1 DGKI

1.84e-0417074417bd7fd25a2657cb536ad47e294332920f759e95
ToppCellfacs-Lung-EPCAM-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCPH1 SECISBP2 HIC2 CNOT1

1.84e-04170744f9decb3bf3bf6d4996b0ac27af768236e116aac5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SPATA31C2 LINC00469 KMO SCML4

1.88e-04171744f6047dee2be0b09ad4d48f97369111bc92e89b35
ToppCelldroplet-Lung-nan-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 IRAG1 SHTN1 KMO

1.88e-0417174406fe7eeffc6e0735342b88e1d1ae26a9b477fece
ToppCellfacs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM221 OBSCN SHTN1 KMO

2.10e-0417674474f851a398c7562dd713bc0d8d488c0037243112
ToppCellfacs-Marrow-T_cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM221 OBSCN SHTN1 KMO

2.10e-0417674431b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCelldroplet-Lung-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZCCHC12 SATB1 CHD3 SCML4

2.20e-04178744730720598c530d2a413ef2a3354ecc66ebb4698c
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 MCPH1 SZT2 SCML4

2.20e-0417874409d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZBTB7C PKHD1 HYDIN ALPK2

2.20e-04178744544379f5a6145429762258d426b876bb36c112f5
ToppCelldroplet-Lung-nan-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZCCHC12 SATB1 CHD3 SCML4

2.20e-041787448fab75295780e18ee7b4556d66b641c20de10dd2
ToppCellB_cells-Naive_B_cells_|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SATB1 MYO7B CHD3 KMO

2.20e-0417874471ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZCCHC12 SATB1 CHD3 SCML4

2.29e-0418074403e3067ee313e8c40b702b9bc9981f9859d045a2
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZCCHC12 SATB1 CHD3 SCML4

2.34e-041817448bab8be68611e49c8aad39b4df0ba0f1c143d118
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARMC3 PKHD1 HYDIN ALPK2

2.34e-041817446956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZCCHC12 LINC00469 KMO SCML4

2.39e-041827447dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARMC3 PKHD1 HYDIN ALPK2

2.39e-041827445e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO7B DIO1 ALPK2 KMO

2.39e-0418274457bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCellCiliated_cells-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

MAP1A ARMC3 HYDIN UBXN10

2.39e-04182744e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYO7B PKHD1 HYDIN ALPK2

2.44e-041837446878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRERF1 MATN2 RIMS1 IRAG1

2.44e-0418374412daaea821e49bc94a01e2496331e92a80d27339
ToppCellCOVID-19-kidney-PCT-S1|kidney / Disease (COVID-19 only), tissue and cell type

MYO7B PKHD1 HYDIN ALPK2

2.49e-0418474451ed1ebfdef45149541917c66cbacad87072e51f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7B OBSCN PKHD1 HYDIN

2.49e-041847442cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7B OBSCN PKHD1 HYDIN

2.49e-04184744ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7B OBSCN PKHD1 HYDIN

2.49e-041847442b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

MYO7B DIO1 ALPK2 KMO

2.49e-04184744dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

2.54e-041857445e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

MAP1A ARMC3 HYDIN UBXN10

2.54e-04185744f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRERF1 MATN2 RIMS1 IRAG1

2.54e-041857443b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

2.60e-0418674476033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARMC3 PKHD1 HYDIN ALPK2

2.60e-041867445c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO7B PKHD1 HYDIN ALPK2

2.60e-04186744f28d72b47624b69a580b4429e2be560a26898591
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

MAP1A ARMC3 HYDIN UBXN10

2.70e-04188744803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MAP1A ARMC3 HYDIN UBXN10

2.70e-0418874482c006f43c93f4a867953a446864f02b44536a23
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MAP1A ARMC3 HYDIN UBXN10

2.70e-04188744da59b5c0a4b11690a39a964c1a0a83e66aa0972b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMBP3 CHST5 VXN S1PR2

2.70e-04188744a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMBP3 CHST5 VXN S1PR2

2.70e-04188744c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellMS-CD8-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

HIC2 FASTKD2 USP37 BAHD1

2.70e-041887442f0e2c7d79ee2d69a5d908c0247dc950c056c30a
ToppCelldroplet-Marrow-BM-1m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HYOU1 MATN2 PYCR3 NUFIP1

2.76e-04189744b81540e097e95158851e07bfd78640ed6e64c2cf
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 DGKI HYDIN

2.76e-04189744cd4746ea6ae48a7dd14a2960d38d9445a738cf2c
ToppCelldroplet-Marrow-BM-1m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HYOU1 MATN2 PYCR3 NUFIP1

2.76e-041897440fda1a3f1e87fadf5309c8267beaa4501983b1dd
ToppCellMulticiliated|World / shred by cell class for nasal brushing

MAP1A ARMC3 HYDIN UBXN10

2.76e-0418974434b110aef839376228c5a403a6b5047a945f472b
ToppCellNasal_Brush-Epithelial-Ciliated_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A ARMC3 HYDIN UBXN10

2.81e-041907449ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCellEpithelial_cells-Ciliated_cells-A|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

MAP1A ARMC3 HYDIN UBXN10

2.81e-04190744549d813a8f23b175875e53347928941f143e236c
ToppCellNasal_Brush-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A ARMC3 HYDIN UBXN10

2.81e-04190744833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCellCiliated_cells-B|World / lung cells shred on cell class, cell subclass, sample id

MAP1A ARMC3 HYDIN UBXN10

2.81e-041907447031fbedc13be1a00f6333ad6d51849c3739c2e6
ToppCellCiliated_cells-A|World / lung cells shred on cell class, cell subclass, sample id

MAP1A ARMC3 HYDIN UBXN10

2.81e-04190744cd87731aaa7d252424f79cfce9f7931457f17bdf
ToppCellEpithelial_cells-Ciliated_cells-B|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

MAP1A ARMC3 HYDIN UBXN10

2.81e-04190744426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCellfacs-Marrow-KLS-18m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 MTHFD2 NAV1 SHTN1

2.81e-04190744c03c735a0ed850bf460a1847f5e2dd61753e577d
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MAP1A ARMC3 HYDIN UBXN10

2.87e-04191744dad675251e129254955eac179c84a641a4864586
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MAP1A ARMC3 HYDIN UBXN10

2.87e-041917446d2cf41ee946137c039ddcc13593fc3f670afbba
ToppCellfacs-GAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB7C MATN2 NAV1 IRAG1

2.87e-041917441f5d1e8c313a8dc83c06d2ee45f369b0ec507fbf
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Stem_cells|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ACACB HJURP KMO SCML4

2.93e-041927441fc95f7e1a71683c8176693c79ee19eabae8b203
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A ARMC3 HYDIN UBXN10

2.93e-04192744be592e661367affced9ebe80849b466e6adb3a34
ToppCellmulticiliated|World / shred by cell class for turbinate

MAP1A ARMC3 HYDIN UBXN10

2.93e-041927440f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Stem_cells-Stem_cells|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ACACB HJURP KMO SCML4

2.93e-04192744378b994d8879512e2769760cfa900aebde90a3e2
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A ARMC3 HYDIN UBXN10

2.99e-041937440b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellLAM-Epithelial-AirwayEpi|Epithelial / Condition, Lineage and Cell class

MAP1A ARMC3 HYDIN UBXN10

2.99e-04193744f2672d2c495ee12c3b7d132452bde581fa5a7856
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SATB1 OBSCN CHD3 SCML4

2.99e-041937443cde93bbfc1ae6fb586ae6b7aaa6ed8b5eee28a4
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SATB1 OBSCN CHD3 SCML4

2.99e-04193744d755dc6de4fbd4d8f5d8a88aac497e7b9e8b89de
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

3.05e-041947441ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellnormal_Lung-Epithelial_cells-Ciliated|Epithelial_cells / Location, Cell class and cell subclass

MAP1A ARMC3 HYDIN UBXN10

3.11e-04195744a3e2999fdd4c3575add6e28ecfd1d6606a61f992
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 HYDIN UBXN10

3.11e-04195744649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SATB1 OBSCN CHD3 SCML4

3.11e-041957444bdedd924564a260841a9153604026b57487c83d
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 HYDIN UBXN10

3.11e-04195744129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 HYDIN UBXN10

3.11e-041957443e70ee987d66d450062d5df3d7c733ccc7344470
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP1A ARMC3 HYDIN UBXN10

3.11e-041957443486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP1A ARMC3 HYDIN UBXN10

3.11e-04195744e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

3.11e-0419574407a6bcef6af93ed87df455dee624037cb75e011a
ToppCellCOVID-19-Epithelial-Ciliated_cells|Epithelial / Condition, Lineage and Cell class

MAP1A ARMC3 HYDIN UBXN10

3.17e-04196744de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP1A ARMC3 HYDIN UBXN10

3.17e-0419674427b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

3.17e-041967449a91a6e5f93ce3bb5a0fc63677553f4c2df95c43
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

3.17e-04196744d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell(05)_Ciliated|World / shred by cell type and Timepoint

CDH26 ARMC3 HYDIN UBXN10

3.23e-04197744fee3cd16af8eea697cd64e8f64af505aaa2ac4b0
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

3.23e-041977446865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 HYDIN UBXN10

3.23e-0419774491637bdeab85024b5a02d1066f76cb803a2d6420
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

3.23e-0419774471fea4aa6ce96c7693fa94792d08770622873850
ToppCellNS-critical-d_0-4-Epithelial-Ciliated-diff|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP1A ARMC3 HYDIN UBXN10

3.23e-0419774462e20ef825b92908d7732aa625dcff7b95ef6ca8
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 HYDIN UBXN10

3.23e-0419774422c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 HYDIN UBXN10

3.23e-041977443bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP1A ARMC3 HYDIN UBXN10

3.23e-04197744e453d085182364ca347cbcc9dc995c62c3353016
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A ARMC3 HYDIN UBXN10

3.23e-0419774487db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Naive_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SATB1 OBSCN CHD3 SCML4

3.23e-04197744836dd8110d5689f944ad1d301def38c32278b5b5
ToppCellhealthy_donor-Lymphocytic-T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

SATB1 OBSCN CHD3 SCML4

3.23e-0419774463d0f06e150e7eb800ecb70e97b9d12a01c84e37
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP1A ARMC3 HYDIN UBXN10

3.23e-04197744d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP1A ARMC3 HYDIN UBXN10

3.29e-04198744ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VPS13C MATN2 PKHD1 ALPK2

3.35e-04199744174f6013af6eafa577f84205a62927f2b367fda3
ToppCellcontrol-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TADA1 SATB1 ACACB HIC2

3.35e-0419974450e2da35edff1aadef939cfbd4549f73c1a07717
Diseasesyndrome (implicated_via_orthology)

ATAD3B ATAD3C CNOT1

8.91e-0618673DOID:225 (implicated_via_orthology)
Diseasethyroid gland disease (is_implicated_in)

DIO1 SECISBP2

1.52e-053672DOID:50 (is_implicated_in)
Diseaseneuromuscular disease (implicated_via_orthology)

ATAD3B ATAD3C

3.04e-054672DOID:440 (implicated_via_orthology)
DiseaseIGF-1 measurement

ACACB MAP1A VPS13C S1PR2 USP37 NUFIP1

8.44e-04488676EFO_0004627
DiseaseSezary Syndrome

KMT2D CHD3

1.72e-0327672C0036920
Diseaseresponse to bronchodilator, FEV/FEC ratio

HYOU1 MCPH1 RP1L1 PKHD1 LINC00469 DHX35 USP37

1.74e-03766677EFO_0004713, GO_0097366

Protein segments in the cluster

PeptideGeneStartEntry
ITTKHMLPTVLRMAG

PPP2R1A

516

P30153
MMLTHLVVRPGLGSK

CHD5

1166

Q8TDI0
RKAFRSTVMHGLMPV

ALPK2

1931

Q86TB3
LMFHPGGLMKLRSRE

ARMC3

851

Q5W041
VSRHIQMSLMGKGEP

LINC00469

16

Q8N7U9
GMLHSMSRLLSTKPS

HJURP

266

Q8NCD3
LGTKGVLRMAPMQLH

RIMBP3B

986

A6NNM3
LGTKGVLRMAPMQLH

RIMBP3C

986

A6NJZ7
MSALEKSMHLGRLPS

PPME1

1

Q9Y570
TMRPSMSGLHLVKRG

ACACB

216

O00763
TGRSPRMMKTITRLH

FAR1

371

Q8WVX9
RMRHLSTGTMTGLAI

MATN2

126

O00339
PLTLFHKMGVGRLDM

MAP1A

186

P78559
GRGKKPTRTLVMTSM

MCPH1

641

Q8NEM0
RMKLSGRPYRHMGVL

PHKA1

491

P46020
GGQHRTTMMPCLLRV

CELF2-AS1

106

Q8N7Q2
TARSMSLTLGKNMPR

IRAG1

671

Q9Y6F6
MGMRHRDRPTTGNTL

MICU1

256

Q9BPX6
RSLPSHHGKKMRMAR

KMT2B

951

Q9UMN6
PKMQGRRMGTSGRSI

RIMS1

1381

Q86UR5
LMLRRTCSTMTGPVH

OBSCN

2436

Q5VST9
ISKPLHYMTIMSRGR

OR4D9

126

Q8NGE8
ILMMLRSHTGEGRRK

OR4D9

221

Q8NGE8
ILAMGEKTGMTRNPH

DIO1

41

P49895
KAMMISIGRPLHSES

EBLN1

166

P0CF75
HSSMFLKGARLIPEM

HYOU1

831

Q9Y4L1
KRNMGDVSMHGLPLV

HYDIN

2421

Q4G0P3
PMRARMIHSLSGKKS

KMO

81

O15229
DLNSGPLHRLTMMIK

FER

91

P16591
PALRKRMLSDSGLGM

DGKI

886

O75912
KMMLTHLVVRPGLGS

CHD3

1201

Q12873
LARTGMKRHLRVLPM

DHX35

301

Q9H5Z1
MTHTRRKSLPMLSSG

BAHD1

1

Q8TBE0
VAPMGREGVTAMHKL

ATAD3C

206

Q5T2N8
MAMRSGRHPSLLLLL

CDH26

1

Q8IXH8
KMMLTHLVVRPGLGS

CHD4

1191

Q14839
LPLRSSSSLERGMHM

S1PR2

326

O95136
SRDNKPRRIHMMSLG

FADS6

256

Q8N9I5
VLKAMLGMPSSTGRH

OR11H1

236

Q8NG94
GSCLMAKALHRMSPT

NUTM2A

41

Q8IVF1
PKLSGLHRSMESLQM

NAV1

876

Q8NEY1
GTMTRHMRSHLGLKP

HIC2

546

Q96JB3
VSSGMLTVSLGRHMR

TAS2R38

211

P59533
IRVHSRLKMGPSMGV

SZT2

2046

Q5T011
RLKMGPSMGVSRAIQ

SZT2

2051

Q5T011
LMSARRSNMGHKEPR

SPATA31C2

921

B4DYI2
LKLCSHTMMLPTRGQ

TADA1

136

Q96BN2
HTMMLPTRGQLEGRM

TADA1

141

Q96BN2
RSKNVGMPIAMLLHT

MTHFD2

201

P13995
KVLRAGMGAHFRMPI

MRM3

251

Q9HC36
LGTKGVLRMAPMQLH

RIMBP3

986

Q9UFD9
LGSSHPRGFLAMKMR

FASTKD2

646

Q9NYY8
RSLMSMIRKRSHPSG

SHTN1

371

A0MZ66
SGERGRRMSQMKTPH

SECISBP2

491

Q96T21
GMHRILMLVRPSGLA

PKHD1

991

P08F94
VKMGMPSSLAHRIAA

PYCR3

196

Q53H96
GHLMKTNLRKGTMLP

SATB1

61

Q01826
PPSKTSMHQSRRLMA

SETDB1

1076

Q15047
VAPMGREGVTAMHKL

ATAD3B

381

Q5T9A4
MGMRARVPKVAHSTR

CHST5

1

Q9GZS9
ARVLGMMARTHSGLT

CNOT1

291

A5YKK6
LGDRPSLVHSRDMKM

PWP1

416

Q13610
MSRHSQMAKIRSPGK

NUFIP1

281

Q9UHK0
MRALMGSKQGRPSSV

RP1L1

1086

Q8IWN7
MARFKVSGGLPLMHV

VPS13C

801

Q709C8
GAMPISSRRCGMITK

SKOR2

106

Q2VWA4
MSPLKIHGPIRIRSM

USP37

1

Q86T82
KVIMGAGKLPRHMRT

ZBTB7C

371

A1YPR0
MLGHRPGSMGKDSTL

TMEM221

276

A6NGB7
MGTEKGAVLMRGSRH

VXN

136

Q8TAG6
GAVLMRGSRHLKKMT

VXN

141

Q8TAG6
MSRSSPSGKGHSRMA

ZNF362

1

Q5T0B9
SLNMHMIRPKSAKGR

UBXN10

31

Q96LJ8
RGRPSLHSTPMKMAV

SCML4

11

Q8N228
LRSLGRSLGPIMASM

ZCCHC12

26

Q6PEW1
MRSHGGMRASPNLKQ

TRERF1

531

Q96PN7
GMALLRNLTMSPLHK

KMT2D

1596

O14686
MVSMAVLPLARARGH

MYO7B

1626

Q6PIF6