Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium,bicarbonate:chloride antiporter activity	SLC4A10 SLC4A8	1.36e-05	3	43	2	GO:0140892
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A10 SLC4A8	6.76e-05	6	43	2	GO:0008510
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC9 ABCC12 ABCC4	1.60e-04	49	43	3	GO:0140359
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	ABCC9 ABCC4	2.02e-04	10	43	2	GO:0043225
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC4A10 SLC4A8	3.48e-04	13	43	2	GO:0140900
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC4A10 SLC4A8	3.48e-04	13	43	2	GO:0140829
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC4A10 SLC4A8	3.48e-04	13	43	2	GO:0140410
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC4A10 ABCC9 ABCC4 SLC4A8	4.94e-04	171	43	4	GO:0015103
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC4A10 ABCC9 ABCC12 ABCC4 SLC4A8 SLC7A13	5.19e-04	477	43	6	GO:0022804
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC9 ABCC12 ABCC4	1.67e-03	109	43	3	GO:0042626
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC4A10 SLC4A8	2.16e-03	32	43	2	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC4A10 SLC4A8	2.16e-03	32	43	2	GO:0005452
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	CHSY3 B4GALNT3	2.58e-03	35	43	2	GO:0008376
GeneOntologyMolecularFunction	antiporter activity	SLC4A10 SLC4A8 SLC7A13	3.26e-03	138	43	3	GO:0015297
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC4A10 ABCC4 SLC4A8 SLC7A13	3.57e-03	293	43	4	GO:0008514
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC4A10 SLC4A8	3.87e-03	43	43	2	GO:0140828
Domain	ABC_membrane	ABCC9 ABCC12 ABCC4	1.79e-05	24	40	3	PF00664
Domain	ABC_TM1F	ABCC9 ABCC12 ABCC4	2.87e-05	28	40	3	PS50929
Domain	ABC1_TM_dom	ABCC9 ABCC12 ABCC4	2.87e-05	28	40	3	IPR011527
Domain	Na/HCO3_transpt	SLC4A10 SLC4A8	4.45e-05	5	40	2	IPR003024
Domain	ANION_EXCHANGER_2	SLC4A10 SLC4A8	9.33e-05	7	40	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A10 SLC4A8	9.33e-05	7	40	2	PS00219
Domain	ABC_transporter_CS	ABCC9 ABCC12 ABCC4	9.86e-05	42	40	3	IPR017871
Domain	Chond_GalNAc	CHSY3 B4GALNT3	1.24e-04	8	40	2	IPR008428
Domain	CHGN	CHSY3 B4GALNT3	1.24e-04	8	40	2	PF05679
Domain	ABC_TRANSPORTER_2	ABCC9 ABCC12 ABCC4	1.47e-04	48	40	3	PS50893
Domain	ABC_tran	ABCC9 ABCC12 ABCC4	1.47e-04	48	40	3	PF00005
Domain	ABC_TRANSPORTER_1	ABCC9 ABCC12 ABCC4	1.57e-04	49	40	3	PS00211
Domain	Band3_cytoplasmic_dom	SLC4A10 SLC4A8	1.59e-04	9	40	2	IPR013769
Domain	Band_3_cyto	SLC4A10 SLC4A8	1.59e-04	9	40	2	PF07565
Domain	-	SLC4A10 SLC4A8	1.59e-04	9	40	2	3.40.1100.10
Domain	ABC_transporter-like	ABCC9 ABCC12 ABCC4	1.66e-04	50	40	3	IPR003439
Domain	PTrfase/Anion_transptr	SLC4A10 SLC4A8	1.99e-04	10	40	2	IPR016152
Domain	HCO3_cotransp	SLC4A10 SLC4A8	1.99e-04	10	40	2	PF00955
Domain	HCO3_transpt_euk	SLC4A10 SLC4A8	1.99e-04	10	40	2	IPR003020
Domain	HCO3_transpt_C	SLC4A10 SLC4A8	1.99e-04	10	40	2	IPR011531
Domain	AAA+_ATPase	ABCC9 ABCC12 ABCC4	3.60e-03	144	40	3	IPR003593
Domain	AAA	ABCC9 ABCC12 ABCC4	3.60e-03	144	40	3	SM00382
Domain	-	CHSY3 B4GALNT3	1.30e-02	81	40	2	3.90.550.10
Domain	Nucleotide-diphossugar_trans	CHSY3 B4GALNT3	1.52e-02	88	40	2	IPR029044
Domain	Cys-rich_flank_reg_C	NYX TLR8	1.59e-02	90	40	2	IPR000483
Domain	LRRCT	NYX TLR8	1.59e-02	90	40	2	SM00082
Pathway	KEGG_ABC_TRANSPORTERS	ABCC9 ABCC12 ABCC4	9.80e-05	44	29	3	M11911
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A10 SLC4A8	1.82e-04	10	29	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A10 SLC4A8	1.82e-04	10	29	2	MM15073
Pubmed	K+-Driven Cl-/HCO3- Exchange Mediated by Slc4a8 and Slc4a10.	SLC4A10 SLC4A8	1.49e-06	2	43	2	38674160
Pubmed	Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.	SLC4A10 SLC4A8	1.49e-05	5	43	2	23500099
Pubmed	Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.	GPC5 B4GALNT3	2.23e-05	6	43	2	20360844
Pubmed	Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.	ABCC12 ABCC4	4.16e-05	8	43	2	15802388
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ATP10B NRXN3 SLC4A8	2.70e-04	101	43	3	9872452
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	ABCC9 ABCC4 SLC4A8	3.02e-04	105	43	3	30280653
Pubmed	Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.	ITGA10 ABCC9	3.72e-04	23	43	2	25190801
Pubmed	NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.	SLC4A10 GABBR1	5.14e-04	27	43	2	23359859
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	SLC4A10 NRXN3 GABBR1	5.40e-04	128	43	3	30995482
Pubmed	Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.	GPC5 NRXN3	7.23e-04	32	43	2	25189868
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DOCK3 ELK3 NPVF GABBR1	7.25e-04	329	43	4	17474147
Pubmed	Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.	DIAPH1 SMARCAL1	7.69e-04	33	43	2	24569637
Cytoband	13q32	ABCC4 GPC5	6.64e-05	13	43	2	13q32
GeneFamily	ATP binding cassette subfamily C	ABCC9 ABCC12 ABCC4	8.41e-07	13	27	3	807
GeneFamily	Beta 4-glycosyltransferases	CHSY3 B4GALNT3	2.88e-04	17	27	2	425
GeneFamily	G protein-coupled receptors, Class A orphans	GPR33 GPR75	6.01e-03	78	27	2	262
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NTSR2 ABCC12 GPC5 RNF43 GABBR1 GPR75	3.80e-08	200	43	6	7a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NTSR2 GPC5 RNF43 GABBR1 GPR75	1.39e-06	200	43	5	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NTSR2 GPC5 RNF43 GABBR1 GPR75	1.39e-06	200	43	5	cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ABCC9 CHSY3 ELK3 NPVF	1.47e-05	154	43	4	511923b27469ea20f8bd82a9ec27119a6e884644
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	SLC4A10 GPC5 NRXN3 NUP210L	1.66e-05	159	43	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC9 RBM44 ABCC12 NRXN3	1.93e-05	165	43	4	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC9 RBM44 ABCC12 NRXN3	1.93e-05	165	43	4	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC7A13 RNF43 ADCY9 GPR75	2.02e-05	167	43	4	9f2661729a2d58e17a9203a563d538c08a3dbbbc
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC7A13 RNF43 ADCY9 GPR75	2.02e-05	167	43	4	bebc2493a2ee41920b21c2b774a1c5a9619315c4
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP10B ABCC4 GPC5 B4GALNT3	3.08e-05	186	43	4	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DIAPH1 ABCC4 NRXN3 B4GALNT3	3.08e-05	186	43	4	a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DIAPH1 ABCC4 NRXN3 B4GALNT3	3.21e-05	188	43	4	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NTSR2 GPC5 GABBR1 GPR75	4.08e-05	200	43	4	07d942803360e1a1e8e131d6e31c726dd0db1a0b
Disease	postherpetic neuralgia	ABCC4 NRXN3	4.99e-05	8	40	2	MONDO_0041052
Disease	cystic fibrosis (implicated_via_orthology)	ABCC12 ABCC4	6.41e-05	9	40	2	DOID:1485 (implicated_via_orthology)
Disease	thyroid stimulating hormone measurement	ELK3 NRXN3 B4GALNT3 ADCY9 MFSD6	7.32e-05	323	40	5	EFO_0004748
Disease	anemia (implicated_via_orthology)	SLC4A10 SLC4A8	1.86e-04	15	40	2	DOID:2355 (implicated_via_orthology)
Disease	response to antineoplastic agent, response to antimicrotubule agent	TMEM131L GPC5	2.12e-04	16	40	2	EFO_0005260, GO_0097327
Disease	hippocampus molecular layer volume	SLC4A10 NUP210L	1.04e-03	35	40	2	EFO_0009397
Disease	Cognition Disorders	SLC4A10 ABCC4	1.22e-03	38	40	2	C0009241
Disease	urate measurement, bone density	DIAPH1 FSIP2 GPC5 FADS2B NUP153	1.43e-03	619	40	5	EFO_0003923, EFO_0004531
Disease	Endometrial Neoplasms	ABCC9 RNF43	2.82e-03	58	40	2	C0014170
Disease	fibroblast growth factor basic measurement	NRXN3 ADCY9	2.92e-03	59	40	2	EFO_0008130
Disease	lifestyle measurement	SLC4A10 DOCK3 MFSD6	3.97e-03	235	40	3	EFO_0010724
Disease	Endometrial Carcinoma	ABCC9 RNF43	4.31e-03	72	40	2	C0476089
Disease	susceptibility to mumps measurement	NRXN3 GABBR1	4.67e-03	75	40	2	EFO_0008404

Protein segments in the cluster

Peptide	Gene	Start	Entry
KFTIIDSLSLSLFTN	B4GALNT3	271	Q6L9W6
LILTVLTTSFNTIFS	GPR33	281	Q49SQ1
LSSLKTFALYTSLSI	ABCC9	526	O60706
LFAKLTLTFSAQTKT	DIAPH1	811	O60610
KASLSTTSSIADFFL	ATP10B	571	O94823
ESKLLSTFSTFASRL	RBM44	686	Q6ZP01
QFLSTSKSKASFFLS	PIP5KL1	131	Q5T9C9
SSSTLLSLFQSFSER	MAGEC1	241	O60732
VSSSFRKLFLEAVSS	NTSR2	361	O95665
TSSSTLKFLISRNAA	GPC5	91	P78333
FLSQKLFISVSVLSS	GABBR1	586	Q9UBS5
LLSKLFSSASSLVLN	FSIP2	4476	Q5CZC0
VISALFSKIFSTISS	FSIP2	6016	Q5CZC0
VSLLSLVTFTFLSAK	PCDHGC5	701	Q9Y5F6
TFSLVTDKSLSTSIF	NRXN3	1431	Q9Y4C0
LTILPTNSSFTSFLT	MFSD6	176	Q6ZSS7
TSFTLATLATLKTSK	GPR75	171	O95800
ISFLLTISQASSSFL	FADS2B	201	A8MWK0
KLFSSLRSKTATFTD	ABCC4	256	O15439
SFFISTQLSSTKLTQ	DOCK3	591	Q8IZD9
SSLLDVFLSTTVFLT	ADCY9	786	O60503
SAFLASSVSAKISSL	ELK3	211	P41970
SSLLSQVFVKLTASS	ITGA10	901	O75578
SQLFLALADSSISTK	DALRD3	381	Q5D0E6
QTLSSLFILLKTTFG	OTOGL	576	Q3ZCN5
TNTLNSTVFKLFITT	NUP210L	1571	Q5VU65
AATTVSRFSSLLSKL	NYX	406	Q9GZU5
TLVSFLSERKTISFS	OR13C9	81	Q8NGT0
LLPTSTTNFTKIASF	TMEM131L	336	A2VDJ0
FEAFTLSLLSSLLTS	PITRM1	341	Q5JRX3
LTLAFASQLKKTSLS	SMARCAL1	401	Q9NZC9
TSSLFNLQKSSLSAR	RNF43	636	Q68DV7
LFFTTFILSSTLKTF	SLC4A8	701	Q2Y0W8
LTFTVALLVTLSFSS	ABCC12	1036	Q96J65
KSSTSLLIFKTTSSL	TPT1P8	121	Q9HAU6
TQSFSFISNSLKILS	CHSY3	591	Q70JA7
SLSDFTSSLRTLLLS	TLR8	706	Q9NR97
KISLLSTDLFSSIQS	ZNF793	121	Q6ZN11
LLTLATSSLLTSNIF	NPVF	11	Q9HCQ7
ILFFSTVTLSATLKQ	SLC4A10	731	Q6U841
STSLFSNLLISIFKS	SLC7A13	296	Q8TCU3
SLLFSQDSKLATTSS	NUP153	1251	P49790
FFSKLQITGTASTIL	TM9SF2	611	Q99805
SSLASTLKTLLFFTA	VMA21	21	Q3ZAQ7