Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RANBP2 RGPD8 KPNA1 RGPD5	9.58e-06	20	142	4	GO:0006607
GeneOntologyBiologicalProcess	social behavior	DRD1 EXT1 GRIN1 VPS13A ULK4 PCM1	1.21e-05	74	142	6	GO:0035176
GeneOntologyBiologicalProcess	biological process involved in intraspecies interaction between organisms	DRD1 EXT1 GRIN1 VPS13A ULK4 PCM1	1.41e-05	76	142	6	GO:0051703
GeneOntologyBiologicalProcess	appendage morphogenesis	CACNA1C TBX4 EXT1 DICER1 TBC1D32 FMN1 CIBAR1 TBX5	4.34e-05	185	142	8	GO:0035107
GeneOntologyBiologicalProcess	limb morphogenesis	CACNA1C TBX4 EXT1 DICER1 TBC1D32 FMN1 CIBAR1 TBX5	4.34e-05	185	142	8	GO:0035108
GeneOntologyBiologicalProcess	response to amine	RANBP2 DRD1 ASIC1 GRIN1 NQO1	4.92e-05	58	142	5	GO:0014075
GeneOntologyBiologicalProcess	T cell differentiation	DOCK2 ADRM1 WWP1 DICER1 CLEC4E PBRM1 SMARCC2 DUSP10 IL2 KIT AP3D1	6.96e-05	382	142	11	GO:0030217
GeneOntologyBiologicalProcess	positive regulation of pseudopodium assembly	F2RL1 CDC42EP2 KIT	8.69e-05	13	142	3	GO:0031274
GeneOntologyBiologicalProcess	regulation of pseudopodium assembly	F2RL1 CDC42EP2 KIT	8.69e-05	13	142	3	GO:0031272
GeneOntologyBiologicalProcess	mononuclear cell differentiation	DOCK2 ADRM1 WWP1 CASP8 F2RL1 DICER1 CLEC4E PBRM1 VPS13A SMARCC2 DUSP10 IL2 KIT AP3D1	1.38e-04	640	142	14	GO:1903131
GeneOntologyBiologicalProcess	response to amphetamine	RANBP2 DRD1 ASIC1 GRIN1	1.62e-04	40	142	4	GO:0001975
GeneOntologyBiologicalProcess	limb development	CACNA1C TBX4 EXT1 DICER1 TBC1D32 FMN1 CIBAR1 TBX5	1.65e-04	224	142	8	GO:0060173
GeneOntologyBiologicalProcess	appendage development	CACNA1C TBX4 EXT1 DICER1 TBC1D32 FMN1 CIBAR1 TBX5	1.65e-04	224	142	8	GO:0048736
HumanPheno	Single transverse palmar crease	ATP6V1A TBX4 NSD2 NEXMIF EXT1 GRIN1 THOC2 PIEZO2 MED25 EHMT1 KDM4B TBX5	3.10e-06	215	57	12	HP:0000954
HumanPheno	Abnormality of the palmar creases	ATP6V1A TBX4 NSD2 NEXMIF EXT1 GRIN1 THOC2 PIEZO2 MED25 EHMT1 KDM4B TBX5	2.19e-05	260	57	12	HP:0010490
HumanPheno	Abnormal palmar dermatoglyphics	ATP6V1A TBX4 NSD2 NEXMIF EXT1 GRIN1 THOC2 PIEZO2 MED25 EHMT1 KDM4B TBX5	2.65e-05	265	57	12	HP:0001018
Domain	EPHD	JADE1 KMT2C KDM4A KDM4B	2.05e-05	22	141	4	PS51805
Domain	PIEZO	PIEZO1 PIEZO2	5.66e-05	2	141	2	PF15917
Domain	Piezo	PIEZO1 PIEZO2	5.66e-05	2	141	2	IPR027272
Domain	Piezo_RRas_bdg	PIEZO1 PIEZO2	5.66e-05	2	141	2	PF12166
Domain	Mediator_Med25	PTOV1 MED25	5.66e-05	2	141	2	IPR021394
Domain	Med25	PTOV1 MED25	5.66e-05	2	141	2	PF11232
Domain	Piezo_RRas-bd_dom	PIEZO1 PIEZO2	5.66e-05	2	141	2	IPR031334
Domain	Piezo_dom	PIEZO1 PIEZO2	5.66e-05	2	141	2	IPR031805
Domain	PHD	BAZ2B NSD2 JADE1 KMT2C KDM4A KDM4B	5.78e-05	89	141	6	SM00249
Domain	Znf_PHD	BAZ2B NSD2 JADE1 KMT2C KDM4A KDM4B	6.55e-05	91	141	6	IPR001965
Domain	ZF_PHD_2	BAZ2B NSD2 JADE1 KMT2C KDM4A KDM4B	8.33e-05	95	141	6	PS50016
Domain	Ran_BP1	RANBP2 RGPD8 RGPD5	8.82e-05	12	141	3	PF00638
Domain	RANBD1	RANBP2 RGPD8 RGPD5	8.82e-05	12	141	3	PS50196
Domain	ZF_PHD_1	BAZ2B NSD2 JADE1 KMT2C KDM4A KDM4B	8.83e-05	96	141	6	PS01359
Domain	RanBD	RANBP2 RGPD8 RGPD5	1.14e-04	13	141	3	SM00160
Domain	Ran_bind_dom	RANBP2 RGPD8 RGPD5	1.14e-04	13	141	3	IPR000156
Domain	Znf_FYVE_PHD	BAZ2B NSD2 JADE1 KMT2C KDM4A FGD6 KDM4B	1.27e-04	147	141	7	IPR011011
Domain	PHD	BAZ2B NSD2 JADE1 KMT2C KDM4B	2.58e-04	75	141	5	PF00628
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ATP6V1A RANBP2 ADRM1 NSD2 POLR2B RECQL RFC1 ECPAS THOC2 EHD2 PBRM1 PA2G4 MED25 NQO1 USP7 EHMT1 SMARCC2 IRX2 PUS7 UBFD1	9.22e-09	1014	145	20	32416067
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	NMNAT1 BAZ2B NSD2 RECQL RFC1 RLF PBRM1 CSN2 USP7 EHMT1 SMARCC2 PUM3 KDM4A KDM4B KPNA1	4.32e-08	608	145	15	36089195
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO1 PIEZO2 AVIL	7.10e-08	3	145	3	30726728
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	NSD2 POLR2B RECQL RFC1 SHTN1 THOC2 TERF2 DENND4C RLF PBRM1 MED25 PUM3 LRBA PCM1 KDM4B	9.28e-08	645	145	15	25281560
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RANBP2 RGPD8 RGPD5	2.83e-07	4	145	3	9480752
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	RGPD8 RFC1 NEB THOC2 MAST2 PBRM1 USP7 SMARCC2 LRBA	6.64e-07	234	145	9	36243803
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 RANBP2 NSD2 RECQL RFC1 ECPAS THOC2 DICER1 PBRM1 USP7 SMARCC2 PUM3 SNX9 PCM1	6.72e-07	653	145	14	22586326
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CACNA1C POLR2B RECQL NEB ECPAS KMT2C ERCC6L2 USP7 KDM4A LRBA AP3D1 KDM4B	1.29e-06	497	145	12	36774506
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	EHMT1 KDM4A KIT KDM4B	2.00e-06	22	145	4	28963472
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	NEMP1 SF3B4 MAGED1 ADRM1 WWP1 DENND4C ABHD4 STK10 PBRM1 CIBAR1 CDC42EP2 LRBA SNX9 FGD6	2.07e-06	719	145	14	35337019
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TPP2 CYP1B1 ATP6V1A RANBP2 TBC1D15 MAGED1 POLR2B RECQL RFC1 ECPAS THOC2 DICER1 EHD2 PA2G4 USP7 PUM3 SLC39A14 SNX9 AP3D1 PCM1	2.44e-06	1440	145	20	30833792
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NEMP1 NSD2 PIEZO1 JADE1 ECPAS DICER1 KMT2C EHMT1 KDM4A DNA2 WNK2 KDM4B	2.45e-06	529	145	12	14621295
Pubmed	Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.	PBRM1 KDM4A KDM4B	2.45e-06	7	145	3	21445275
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ABCA4 TBX4 RFC1 NEB ABCC6 RYR1 TBC1D32 THBS1 PBRM1 VPS13A EHMT1 SMARCC2 KPNA1	2.99e-06	638	145	13	31182584
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	TPP2 ATP6V1A TBC1D15 TES NSD2 ECPAS DICER1 USP7 PUM3 SLC39A14 DNA2 PCM1 YIPF6 KPNA1	3.58e-06	754	145	14	33060197
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SYNRG TBC1D15 TES POLR2B SHTN1 THOC2 KMT2C USP7 LRBA SNX9 PCM1 RGPD5	3.59e-06	549	145	12	38280479
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DOCK2 TPP2 RANBP2 BAZ2B RECQL RFC1 ECPAS THOC2 RLF STK10 KMT2C PA2G4 EHMT1 SMARCC2 PUM3 SNX9 PCM1	3.81e-06	1103	145	17	34189442
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CCDC8 NMNAT1 NSD2 POLR2B RFC1 THOC2 TERF2 FAM133B PBRM1 PA2G4 PNMA8A PUM3 IQGAP3 AP3D1	3.87e-06	759	145	14	35915203
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SYNRG NSD2 WWP1 PIEZO1 IRS1 JADE1 MAST2 RYR1 STK10 KMT2C USP7 EHMT1 ULK4 LRBA IQGAP3 AP3D1 WNK2	3.91e-06	1105	145	17	35748872
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	ASIC1 PIEZO1 PIEZO2	3.91e-06	8	145	3	27161260
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CACNA1C ATP6V1A NSD2 WWP1 ECPAS SHTN1 RLF STK10 KMT2C PPP2R3A EHMT1 ASTN2 LRBA POLK SNX9 BAIAP3 WNK2 PCM1 KDM4B KPNA1	4.02e-06	1489	145	20	28611215
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	RANBP2 MAGED1 RFC1 PARP14 TERF2 KMT2C PBRM1 USP7 EHMT1 SMARCC2 DNA2	4.77e-06	469	145	11	27634302
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	ATP6V1A RANBP2 SF3B4 MAGED1 ADRM1 POLR2B SHMT1 RECQL RFC1 ECPAS SHTN1 PA2G4 USP7 SNX9 IQGAP3 AP3D1 KPNA1	6.53e-06	1149	145	17	35446349
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	SF3B4 RFC1 THOC2 TERF2 PBRM1 USP7 SMARCC2 DNA2 IQGAP3 AP3D1 KPNA1	6.68e-06	486	145	11	30940648
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ATP6V1A SYNRG RANBP2 TES RFC1 SHTN1 THOC2 PA2G4 USP7 LRBA SNX9 AP3D1 PCM1 PUS7 UBFD1	9.06e-06	934	145	15	33916271
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	EHMT1 KDM4A KDM4B	1.14e-05	11	145	3	19144645
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CYP1B1 RANBP2 MAGED1 NSD2 PIEZO1 POLR2B TERF2 DICER1 FAM133B KMT2C PBRM1 PA2G4 MED25 USP7 EHMT1 PUM3 IQGAP3 KPNA1 CYBA	1.58e-05	1497	145	19	31527615
Pubmed	Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability.	KMT2C EHMT1	1.73e-05	2	145	2	22726846
Pubmed	Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.	PIEZO1 PIEZO2	1.73e-05	2	145	2	37820892
Pubmed	Tbx4/5 gene duplication and the origin of vertebrate paired appendages.	TBX4 TBX5	1.73e-05	2	145	2	19995988
Pubmed	Different regulation of T-box genes Tbx4 and Tbx5 during limb development and limb regeneration.	TBX4 TBX5	1.73e-05	2	145	2	12376111
Pubmed	T-box genes and the formation of vertebrate forelimb- and hindlimb specific pattern.	TBX4 TBX5	1.73e-05	2	145	2	10199965
Pubmed	Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms.	CACNA1C DRD1	1.73e-05	2	145	2	29089442
Pubmed	The role of PIEZO ion channels in the musculoskeletal system.	PIEZO1 PIEZO2	1.73e-05	2	145	2	36717101
Pubmed	Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.	STK10 KIT	1.73e-05	2	145	2	16175573
Pubmed	IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli.	KDM4A IRX2	1.73e-05	2	145	2	36181956
Pubmed	A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.	PIEZO1 PIEZO2	1.73e-05	2	145	2	32142647
Pubmed	Two conserved epigenetic regulators prevent healthy ageing.	BAZ2B EHMT1	1.73e-05	2	145	2	32103178
Pubmed	Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice.	CACNA1C TRPC3	1.73e-05	2	145	2	27522668
Pubmed	PTOV1 antagonizes MED25 in RAR transcriptional activation.	PTOV1 MED25	1.73e-05	2	145	2	21110951
Pubmed	ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum.	ABCA4 ABCC6	1.73e-05	2	145	2	12673275
Pubmed	Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder.	KMT2C EHMT1	1.73e-05	2	145	2	29069077
Pubmed	Mechanosensitive channels: in touch with Piezo.	PIEZO1 PIEZO2	1.73e-05	2	145	2	21056836
Pubmed	Astrocytes in the optic nerve head express putative mechanosensitive channels.	PIEZO1 PIEZO2	1.73e-05	2	145	2	26236150
Pubmed	Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.	PIEZO1 PIEZO2	1.73e-05	2	145	2	38928429
Pubmed	A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.	PIEZO1 PIEZO2	1.73e-05	2	145	2	30628892
Pubmed	Piezo1 ion channel pore properties are dictated by C-terminal region.	PIEZO1 PIEZO2	1.73e-05	2	145	2	26008989
Pubmed	Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.	PIEZO1 PIEZO2	1.73e-05	2	145	2	20813920
Pubmed	Lethal multiple pterygium syndrome, large cystic hygroma, and cleft palate: Rare and severe fetal presentations of RYR1- and NEB-related congenital myopathies.	NEB RYR1	1.73e-05	2	145	2	38520674
Pubmed	Expression of the Abca-subfamily of genes in Abcc6-/- mice--upregulation of Abca4.	ABCA4 ABCC6	1.73e-05	2	145	2	21435020
Pubmed	Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.	DRD1 GRIN1	1.73e-05	2	145	2	8795639
Pubmed	Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels.	ASIC1 PIEZO1	1.73e-05	2	145	2	26924440
Pubmed	Genetic and developmental bases of serial homology in vertebrate limb evolution.	TBX4 TBX5	1.73e-05	2	145	2	11076746
Pubmed	[Feeling the pressure? Identification of two proteins activated by mechanical forces].	PIEZO1 PIEZO2	1.73e-05	2	145	2	21299953
Pubmed	Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.	PIEZO1 PIEZO2	1.73e-05	2	145	2	38395992
Pubmed	Mechanisms of mechanotransduction and physiological roles of PIEZO channels.	PIEZO1 PIEZO2	1.73e-05	2	145	2	39251883
Pubmed	USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.	DICER1 USP7	1.73e-05	2	145	2	37867415
Pubmed	Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.	PIEZO1 PIEZO2	1.73e-05	2	145	2	37975162
Pubmed	Reader domain specificity and lysine demethylase-4 family function.	KDM4A KDM4B	1.73e-05	2	145	2	27841353
Pubmed	Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.	PIEZO1 PIEZO2	1.73e-05	2	145	2	28636944
Pubmed	Piezo channels: from structure to function.	PIEZO1 PIEZO2	1.73e-05	2	145	2	25037583
Pubmed	Isoproterenol-induced hypertrophy of neonatal cardiac myocytes and H9c2 cell is dependent on TRPC3-regulated CaV1.2 expression.	CACNA1C TRPC3	1.73e-05	2	145	2	33069962
Pubmed	The CARD9-Associated C-Type Lectin, Mincle, Recognizes La Crosse Virus (LACV) but Plays a Limited Role in Early Antiviral Responses against LACV.	CLEC4E CARD9	1.73e-05	2	145	2	30917612
Pubmed	Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.	PIEZO1 PIEZO2	1.73e-05	2	145	2	34464353
Pubmed	Changes in activities of caspase-8 and caspase-9 in human cervical malignancy.	CASP8 CARD9	1.73e-05	2	145	2	21436691
Pubmed	TRPC3-interacting triadic proteins in skeletal muscle.	TRPC3 RYR1	1.73e-05	2	145	2	18215135
Pubmed	Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?	PIEZO1 PIEZO2	1.73e-05	2	145	2	30324494
Pubmed	Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis.	IL2 KIT	1.73e-05	2	145	2	21982597
Pubmed	Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population.	TBX4 NOX3	1.73e-05	2	145	2	30290780
Pubmed	Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins.	TRPC3 RYR1	1.73e-05	2	145	2	16484216
Pubmed	Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression.	CACNA1C RYR1	1.73e-05	2	145	2	18927079
Pubmed	Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.	PIEZO1 PIEZO2	1.73e-05	2	145	2	30745454
Pubmed	Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.	PIEZO1 PIEZO2	1.73e-05	2	145	2	27743844
Pubmed	Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels.	GRIN1 AVIL	1.73e-05	2	145	2	23946399
Pubmed	Expression of Pentraxin 3 and Thrombospondin 1 in Gingival Crevicular Fluid during Wound Healing after Gingivectomy in Postorthodontic Patients.	THBS1 PTX3	1.73e-05	2	145	2	27403446
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	RFC1 PBRM1 MED25 USP7 SMARCC2 LRBA	1.77e-05	129	145	6	23022380
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TES NSD2 WWP1 POLR2B MAST2 DICER1 PBRM1 MCTP1 CIBAR1 USP7 EHMT1 SMARCC2 DNA2 IRX2 PCM1 KPNA1	1.82e-05	1116	145	16	31753913
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	RANBP2 NSD2 POLR2B RFC1 PBRM1 SMARCC2 PUM3	1.88e-05	195	145	7	19454010
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	ATP6V1A RANBP2 TBC1D15 MAGED1 RGPD8 ADRM1 POLR2B SHMT1 RFC1 THOC2 PTOV1 PA2G4 USP7 DNA2 IQGAP3 KPNA1 RGPD5	2.07e-05	1257	145	17	37317656
Pubmed	Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.	LAMA4 THBS1 TBX5	2.50e-05	14	145	3	36347239
Pubmed	Large-scale concatenation cDNA sequencing.	CACNA1C POLR2B EXT1 ECPAS DICER1 PTOV1 VPS13A MED25 BAIAP3 KDM4B KPNA1	2.82e-05	568	145	11	9110174
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RANBP2 TBC1D15 TES SHTN1 PA2G4 VPS13A LRBA SLC39A14 SNX9 PCM1 UBFD1	2.82e-05	568	145	11	37774976
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ATP6V1A RANBP2 TBC1D15 NSD2 POLR2B RECQL RFC1 ECPAS THOC2 MAST2 DICER1 PBRM1 PA2G4 SERPINB12 USP7 EHMT1 PUM3 IQGAP3	2.87e-05	1425	145	18	30948266
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	RANBP2 POLR2B RLF PBRM1 USP7 SMARCC2	4.13e-05	150	145	6	28242625
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TPP2 RANBP2 TES POLR2B RECQL PA2G4 EHMT1 PUM3 LRBA IQGAP3 AP3D1 KPNA1	4.21e-05	704	145	12	29955894
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	RANBP2 POLR2B NEB DMXL1 PUM3	4.32e-05	92	145	5	15840729
Pubmed	Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial.	RNASEL IL2	5.16e-05	3	145	2	26771888
Pubmed	Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.	CYP1B1 NQO1	5.16e-05	3	145	2	23692925
Pubmed	Mast cells instruct keratinocytes to produce thymic stromal lymphopoietin: Relevance of the tryptase/protease-activated receptor 2 axis.	F2RL1 DICER1	5.16e-05	3	145	2	35240143
Pubmed	Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice.	DICER1 KIT	5.16e-05	3	145	2	25783852
Pubmed	Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.	TERF2 DNA2	5.16e-05	3	145	2	23604072
Pubmed	Calcineurin Inhibition Causes α2δ-1-Mediated Tonic Activation of Synaptic NMDA Receptors and Pain Hypersensitivity.	GRIN1 AVIL	5.16e-05	3	145	2	32269108
Pubmed	The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.	NOX3 CYBA	5.16e-05	3	145	2	15824103
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	DRD1 RYR1	5.16e-05	3	145	2	23278119
Pubmed	Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.	KDM4A KDM4B	5.16e-05	3	145	2	17611647
Pubmed	Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth.	TBX4 TBX5	5.16e-05	3	145	2	15621531
Pubmed	Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.	PIEZO1 PIEZO2	5.16e-05	3	145	2	29521261
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO1 PIEZO2	5.16e-05	3	145	2	37321223
Pubmed	DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.	DOCK2 KIT	5.16e-05	3	145	2	24913231
Pubmed	A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes.	NOX3 CYBA	5.16e-05	3	145	2	17336700
Interaction	KDM4B interactions	PARP14 KMT2C PBRM1 KDM4A PUS7 KDM4B	1.08e-05	71	142	6	int:KDM4B
Interaction	KPNA2 interactions	NEMP1 RANBP2 CCDC8 MAGED1 RGPD8 NMNAT1 RECQL TERF2 GSK3A PBRM1 SMARCC2 KPNA1 RGPD5 TBX5	1.86e-05	519	142	14	int:KPNA2
Interaction	RGPD1 interactions	RANBP2 RGPD8 GSK3A PBRM1 RGPD5	2.40e-05	49	142	5	int:RGPD1
Interaction	HDAC1 interactions	RANBP2 HNF1B TBC1D15 ADRM1 NSD2 RFC1 ECPAS SHTN1 DENND4C GSK3A RLF PTOV1 TBC1D32 USP7 EHMT1 SMARCC2 KDM4A LRBA SNX9 PCM1 KPNA1	3.27e-05	1108	142	21	int:HDAC1
Interaction	H2BC21 interactions	NMNAT1 NSD2 POLR2B FAM47B RECQL JADE1 RFC1 NEB TERF2 RLF PBRM1 MED25 USP7 EHMT1 SMARCC2 KPNA1	3.29e-05	696	142	16	int:H2BC21
Interaction	SCARF1 interactions	NEMP1 SLC7A14 AVIL USP7	3.66e-05	27	142	4	int:SCARF1
Interaction	RGPD2 interactions	NEMP1 RANBP2 RGPD8 RGPD5	3.66e-05	27	142	4	int:RGPD2
Interaction	SIRT6 interactions	RANBP2 CCDC8 RGPD8 POLR2B DICER1 PBRM1 NQO1 USP7 EHMT1 SMARCC2 PUM3 SNX9 IQGAP3 KPNA1 RGPD5	3.81e-05	628	142	15	int:SIRT6
Interaction	H3C3 interactions	NMNAT1 BAZ2B NSD2 RECQL RFC1 RLF PBRM1 CSN2 EHMT1 SMARCC2 PUM3 KDM4B KPNA1	4.94e-05	495	142	13	int:H3C3
Interaction	CLTC interactions	RANBP2 CCDC8 TES ADRM1 GRIN1 ABCC6 EHD2 CLEC4E AP3B2 USP7 LRBA SNX9 KIT AP3D1 PCM1	6.13e-05	655	142	15	int:CLTC
Interaction	SOX9 interactions	NEMP1 HNF1B KMT2C PBRM1 USP7 SMARCC2	6.43e-05	97	142	6	int:SOX9
Cytoband	4q26-q27	JADE1 IL2	5.92e-05	4	145	2	4q26-q27
Cytoband	5q35.1	DOCK2 DRD1 STK10	2.40e-04	38	145	3	5q35.1
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	TRIM2 BAZ2B WWP1 RECQL EXT1 RFC1 SHTN1 DMXL1 KIAA0319 RLF PPP2R3A PIEZO2 PBRM1 PUM3 POLK KIT PCM1	1.45e-07	656	145	17	M18979
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	RANBP2 TRIM2 BAZ2B WWP1 POLR2B CASP8 IRS1 EXT1 THOC2 MAST2 DICER1 RLF STK10 PPP2R3A PTX3 VPS13A USP7 PUM3	1.28e-06	856	145	18	M4500
Coexpression	PATEL_SKIN_OF_BODY_ZOSTAVAX_AGE_70_93YO_VZV_CHALLENGE_6HR_UP	POTEKP ECPAS THBS1 MCTP1 PTX3 VCAN CDC42EP2 SLC39A14 IRX2 FGD6	5.38e-06	291	145	10	M41002
Coexpression	PLASARI_TGFB1_TARGETS_10HR_DN	CYP1B1 TRIM2 LAMA4 IRS1 RNASEL SLC16A4 PTX3 NQO1 CDC42EP2	1.43e-05	258	145	9	M2446
Coexpression	PLASARI_TGFB1_TARGETS_10HR_DN	CYP1B1 TRIM2 LAMA4 IRS1 RNASEL SLC16A4 PTX3 NQO1 CDC42EP2	2.11e-05	271	145	9	MM1075
Coexpression	CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70	CASP8 GRIN1 VCAN AP3D1 CTSW	3.81e-05	68	145	5	M305
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TBX4 TRPC3 LAMA4 EXT1 PIEZO2 VCAN PUM3 TBX5	1.78e-07	187	144	8	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C TBX4 LAMA4 EXT1 THBS1 PIEZO2 VCAN TBX5	2.75e-07	198	144	8	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CASP8 PARP14 SCML4 FAM133B VPS13A LRBA PCM1 RGPD5	2.86e-07	199	144	8	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	10x5'-GI_small-bowel-Myeloid_Monocytic\|GI_small-bowel / Manually curated celltypes from each tissue	CYP1B1 CLEC4E THBS1 MCTP1 PTX3 VCAN CDC42EP2	1.44e-06	171	144	7	098a7fd387357c0d4e1a6169af4d24ef95b30018
ToppCell	10x5'-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	CYP1B1 CLEC4E THBS1 MCTP1 PTX3 VCAN CDC42EP2	1.61e-06	174	144	7	05d54a36772f096047521e16a89cc42ae48d2a1d
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	GPR155 RANBP2 TRIM2 NEXMIF SLC7A14 AP3B2 ASTN2	1.95e-06	179	144	7	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C TBX4 IRS1 F2RL1 THBS1 VCAN TBX5	2.18e-06	182	144	7	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	3'_v3-GI_small-bowel-Myeloid_Monocytic-Nonclassical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	CYP1B1 SHTN1 CLEC4E THBS1 PTX3 VCAN CDC42EP2	2.60e-06	187	144	7	c20689022569640ebc4a878e3fe146b86fe9b386
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1C TBX4 LAMA4 THBS1 PIEZO2 PTX3 TBX5	2.60e-06	187	144	7	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C LAMA4 EXT1 THBS1 PIEZO2 VCAN SLC39A14	2.99e-06	191	144	7	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C TBX4 LAMA4 EXT1 PIEZO2 ULK4 TBX5	3.21e-06	193	144	7	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	PND10-Mesenchymal\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBX4 MAGED1 ASPN LAMA4 THBS1 VCAN TBX5	3.55e-06	196	144	7	ace167a40adb7022b365be3c2b1cbd4ba963739a
ToppCell	390C-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CYP1B1 STK10 THBS1 PTX3 VCAN CDC42EP2 CYBA	3.67e-06	197	144	7	cd941c5ef76897047bd8508d98510c4ff164d223
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C TBX4 LAMA4 THBS1 PIEZO2 VCAN TBX5	3.80e-06	198	144	7	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP1B1 CLEC4E THBS1 PTX3 VCAN CDC42EP2 CYBA	3.80e-06	198	144	7	c288b29287a562460d8970264e1833801590da73
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	BAZ2B WWP1 IRS1 JADE1 RFC1 NQO1 KIT	3.92e-06	199	144	7	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Transverse-(4)_Monocyte\|Transverse / shred on region, Cell_type, and subtype	CYP1B1 CLEC4E THBS1 MCTP1 PTX3 VCAN CDC42EP2	4.06e-06	200	144	7	85714e8da539366b5bce071dfea8f8055de527bc
ToppCell	Transverse-Monocyte-Monocyte\|Transverse / Region, Cell class and subclass	CYP1B1 CLEC4E THBS1 MCTP1 PTX3 VCAN CDC42EP2	4.06e-06	200	144	7	96ecfab57e998134e164b4a62881ef6f2612bd8d
ToppCell	Transverse-Monocyte\|Transverse / Region, Cell class and subclass	CYP1B1 CLEC4E THBS1 MCTP1 PTX3 VCAN CDC42EP2	4.06e-06	200	144	7	d70aeb57b98496474b97906505576640fdbdf34c
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C TBX4 LAMA4 THBS1 PIEZO2 VCAN TBX5	4.06e-06	200	144	7	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Transverse-(4)_Monocyte-(40)_Monocyte\|Transverse / shred on region, Cell_type, and subtype	CYP1B1 CLEC4E THBS1 MCTP1 PTX3 VCAN CDC42EP2	4.06e-06	200	144	7	0187a4b1d2c3c89b7769d632e6d88190a06b093e
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C TBX4 LAMA4 THBS1 PIEZO2 VCAN TBX5	4.06e-06	200	144	7	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	(40)_Monocyte\|World / shred on Cell_type and subtype	CYP1B1 CLEC4E THBS1 MCTP1 PTX3 VCAN CDC42EP2	4.92e-06	206	144	7	d78a70f951265ef6df8f64404107be4f53e75d28
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NEB F2RL1 EHD2 CLEC4E THBS1 VCAN	1.52e-05	163	144	6	4be3158f2a0ab460cfea8080a7370922910b5da9
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ABCC6 CLEC4E DUSP10 IRX2 BAIAP3 RGPD5	1.93e-05	170	144	6	a6fa0cab1fa829ec601fe48306b4c43c83425b04
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ABCC6 CLEC4E DUSP10 IRX2 BAIAP3 RGPD5	1.93e-05	170	144	6	b40255eee45eb18b5a297336d7f3845fd8f8aa3b
ToppCell	ILEUM-non-inflamed-(3)_Inf._Macrophages\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CYP1B1 SHTN1 CLEC4E THBS1 VCAN CDC42EP2	2.13e-05	173	144	6	a8db746992a915a8431ac5c155612e89c4af3cad
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C IRS1 GRIN1 TERF2 DENND4C ULK4	2.20e-05	174	144	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	droplet-Liver-Npc-21m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TES F2RL1 PIEZO2 PTX3 IRX2 CTSW	2.27e-05	175	144	6	046e841811b22c39f80a9752f3223c1906de6f20
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-MAIT_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPP2 RGPD8 CLEC4E ZNF382 DUSP10 CTSW	2.50e-05	178	144	6	0290868dc990878eac5c182fe64968333bc52450
ToppCell	COVID-19-kidney-Mito-rich_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK2 SCML4 STK10 CLEC4E CTSW CYBA	2.75e-05	181	144	6	8448c2ad560cfd48bfe9dc1dd3a64373e6a622dd
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	SHTN1 SCML4 FMN1 DUSP10 LRBA SNX9	2.75e-05	181	144	6	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HNF1B TRIM2 NEXMIF F2RL1 THBS1 IRX2	2.83e-05	182	144	6	204530444e35d4977a7239ac176f477e9e5c29ab
ToppCell	tumor_Lung-Fibroblasts-Pericytes\|tumor_Lung / Location, Cell class and cell subclass	CACNA1C TBX4 ASPN TRPC3 LAMA4 EHD2	2.92e-05	183	144	6	a03dd563af9b15cb1f5de5732a229405a9f82d84
ToppCell	droplet-Marrow-nan-3m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECPAS PTOV1 CIBAR1 KIT PCM1 UBFD1	2.92e-05	183	144	6	92ef926e6c1de8477fa4f35d1dae85482d8009de
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epi_progenitor\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TRIM2 NEXMIF SHTN1 F2RL1 THBS1 IRX2	2.92e-05	183	144	6	031b4ffd95114dc10d2932c67d2cfef139b3fd2e
ToppCell	droplet-Marrow-nan-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECPAS PTOV1 CIBAR1 KIT PCM1 UBFD1	2.92e-05	183	144	6	24db9cc717e651586317c6a8e03a3401651273c1
ToppCell	droplet-Lung-nan-21m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEXMIF TRPC3 LAMA4 PTX3 NQO1 FGD6	3.10e-05	185	144	6	3a4ae836e882e8d29eb0a2dfab5677f10f2d365f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM2 IRS1 PPP2R3A FMN1 ASTN2 LRBA	3.10e-05	185	144	6	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	droplet-Lung-nan-21m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEXMIF TRPC3 LAMA4 PTX3 NQO1 FGD6	3.10e-05	185	144	6	224f0b022c21dd40bf1f7503f00b3107ef958975
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM2 IRS1 PPP2R3A FMN1 ASTN2 LRBA	3.20e-05	186	144	6	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM2 IRS1 PPP2R3A FMN1 ASTN2 LRBA	3.20e-05	186	144	6	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	E12.5-Epithelial\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HNF1B TRIM2 NEXMIF F2RL1 THBS1 IRX2	3.30e-05	187	144	6	29ea5e14dac3321df76f6aa4f053068b49c4a4bf
ToppCell	10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RANBP2 CCDC168 NEB SCML4 IL2 KIT	3.30e-05	187	144	6	f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	CYP1B1 EXT1 CLEC4E THBS1 FMN1 VCAN	3.50e-05	189	144	6	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	CYP1B1 EXT1 CLEC4E THBS1 FMN1 VCAN	3.50e-05	189	144	6	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM2 NEXMIF DENND4C FMN1 ASTN2 IRX2	3.50e-05	189	144	6	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C TBX4 ASPN TRPC3 IRS1 TBX5	3.50e-05	189	144	6	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP2S1 SHTN1 CLEC4E THBS1 MCTP1 VCAN	3.50e-05	189	144	6	e4b2f00cb3675a4d94e8807d6ff99cc55f9ed233
ToppCell	3'_v3-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	CYP1B1 SHTN1 CLEC4E THBS1 VCAN CDC42EP2	3.50e-05	189	144	6	74a5e61cd820f2495dde40e766c771a31d8c4e7d
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C LAMA4 THBS1 PIEZO2 ASTN2 TBX5	3.50e-05	189	144	6	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TBX4 MAGED1 LAMA4 THBS1 VCAN TBX5	3.50e-05	189	144	6	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK2 GPR155 WWP1 RYR1 FMN1 SNX9	3.60e-05	190	144	6	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	facs-Lung-nan-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGR3 CYP2S1 SLC7A14 KIAA0319 WDR93 ULK4	3.60e-05	190	144	6	e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCell	Control-Myeloid-Transitioning_MDM\|Control / group, cell type (main and fine annotations)	DOCK2 THBS1 MCTP1 FMN1 VCAN SNX9	3.60e-05	190	144	6	d6fd8c23cde4a10cc1517b6899a5a855fdfff2e2
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEXMIF TRPC3 LAMA4 PTX3 NQO1 FGD6	3.60e-05	190	144	6	f50b9814a1beac67dc042a8c27dfd085ceeda3a6
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEXMIF TRPC3 LAMA4 PTX3 NQO1 FGD6	3.60e-05	190	144	6	a22a510b4a257eb0eaf09c7ae7978d3d2f07a58c
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	CACNA1C LAMA4 THBS1 PIEZO2 VCAN TBX5	3.60e-05	190	144	6	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	facs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGR3 CYP2S1 SLC7A14 KIAA0319 WDR93 ULK4	3.60e-05	190	144	6	fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NEMP1 NSD2 MAST2 SLC16A4 DNA2 IQGAP3	3.60e-05	190	144	6	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEXMIF TRPC3 LAMA4 PTX3 NQO1 FGD6	3.60e-05	190	144	6	57c136bf6d7feafb4a220877bed0cc8fdf314db2
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C LAMA4 THBS1 PIEZO2 VCAN TBX5	3.71e-05	191	144	6	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C TBX4 ASPN TRPC3 IRS1 TBX5	3.71e-05	191	144	6	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYP1B1 SHTN1 CLEC4E MCTP1 PTX3 VCAN	3.71e-05	191	144	6	9f0d956e9a14b1cd2c20a52639c6b22c349b377e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 STK10 CLEC4E MCTP1 FMN1 VCAN	3.71e-05	191	144	6	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK2 GPR155 DENND1C SCML4 STK10 CTSW	3.82e-05	192	144	6	92f141d5ac462f652f405efa73ac6ef751f40ea3
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 ASIC1 ASPN LAMA4 PTX3 VCAN	3.82e-05	192	144	6	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C CYP1B1 THBS1 PIEZO2 PTX3 SLC39A14	3.82e-05	192	144	6	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C TBX4 LAMA4 THBS1 PIEZO2 TBX5	3.82e-05	192	144	6	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 ASIC1 ASPN LAMA4 PTX3 VCAN	3.82e-05	192	144	6	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C TBX4 LAMA4 THBS1 PIEZO2 TBX5	3.82e-05	192	144	6	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	LPS-IL1RA-Stromal_mesenchymal\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C CYP1B1 TBX4 THBS1 PIEZO2 TBX5	3.82e-05	192	144	6	4e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYP1B1 SHTN1 CLEC4E MCTP1 PTX3 VCAN	3.93e-05	193	144	6	45205ad1ef12aabf33059a7ff922a3bb86994c2f
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RGPD8 EXT1 KMT2C FMN1 LRBA SNX9	3.93e-05	193	144	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Monocytes\|metastatic_Lymph_Node / Location, Cell class and cell subclass	CYP1B1 CLEC4E THBS1 PTX3 VCAN CYBA	3.93e-05	193	144	6	e67e960a5312ed73c5169795cb282e431866b9c1
ToppCell	Control-Myeloid-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	DOCK2 GPR155 RYR1 MCTP1 FMN1 SNX9	3.93e-05	193	144	6	a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYP1B1 SHTN1 CLEC4E MCTP1 PTX3 VCAN	3.93e-05	193	144	6	1beca3d3b34082b7d9112fbd094bee8019921ca0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYP1B1 SHTN1 CLEC4E MCTP1 PTX3 VCAN	3.93e-05	193	144	6	2ebb950476767f330241b0077ced22e55e124359
ToppCell	Immune-interstitial_macrophage_(C1Q_positive)\|World / Lineage, Cell type, age group and donor	DOCK2 WWP1 RYR1 MCTP1 FMN1 SNX9	3.93e-05	193	144	6	64d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCell	367C-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CYP1B1 CLEC4E THBS1 PTX3 VCAN CDC42EP2	3.93e-05	193	144	6	c7ecd98729419b34c14f9b387b15472c47951d2f
ToppCell	facs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHMT1 ABHD4 PTOV1 PUM3 KIT PUS7	4.05e-05	194	144	6	c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TBX4 TRPC3 PIEZO2 PTX3 VCAN TBX5	4.05e-05	194	144	6	28c5482da199bcee9e85258a88af453d9fdbd56a
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C TBX4 LAMA4 PIEZO2 VCAN TBX5	4.05e-05	194	144	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Mesenchymal\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CYP1B1 DRD1 ABCA4 ASPN LAMA4 NQO1	4.05e-05	194	144	6	638b9fdce64ed00243b5303800ec66207d5fd640
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Mesenchymal-choroid_plexus/mesenchymal-like_cells\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CYP1B1 DRD1 ABCA4 ASPN LAMA4 NQO1	4.05e-05	194	144	6	e9868c22934b6c0ac35e3e8270ec0b671bc6582a
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C ASPN TRPC3 LAMA4 IRS1 TBX5	4.05e-05	194	144	6	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBX4 GRIN1 RFC1 PA2G4 VCAN TBX5	4.05e-05	194	144	6	af4bbb2deb5a3913eb58990690fc3c62fbc3708c
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C TBX4 LAMA4 THBS1 PIEZO2 TBX5	4.05e-05	194	144	6	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	356C-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CYP1B1 CLEC4E THBS1 PTX3 VCAN CDC42EP2	4.05e-05	194	144	6	3f9ac1de8605a7930f49a7ce0e32aea9997d7791
ToppCell	21-Trachea-Mesenchymal\|Trachea / Age, Tissue, Lineage and Cell class	TBX4 ASPN LAMA4 EHD2 PIEZO2 TBX5	4.05e-05	194	144	6	749dd8113ef260e00facac09de9861d61725124a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 DENND4C RYR1 STK10 MCTP1 FMN1	4.05e-05	194	144	6	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	356C-Myeloid-Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CYP1B1 CLEC4E THBS1 PTX3 VCAN CDC42EP2	4.05e-05	194	144	6	a41cde3088b43670210daab4f43a24aa83dbd45b
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TBX4 TRPC3 IRS1 PIEZO2 VCAN TBX5	4.16e-05	195	144	6	c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCell	P07-Mesenchymal\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TBX4 MAGED1 ASPN THBS1 VCAN TBX5	4.16e-05	195	144	6	859764b605866b6c3e6edd0698670ca9c0f20745
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP1B1 SHTN1 CLEC4E THBS1 PTX3 VCAN	4.16e-05	195	144	6	580ed65b4152483b642a7e7dbdf00d03588c46f6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 DENND4C RYR1 STK10 MCTP1 FMN1	4.16e-05	195	144	6	247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP1B1 SHTN1 CLEC4E THBS1 MCTP1 VCAN	4.16e-05	195	144	6	403d874198a7bde626b0d0b4efad8dbb34060761
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TBX4 F2RL1 ABCC6 SLC16A4 CTSW	4.27e-05	119	144	5	a3807e738d7ca8cf80aa4bd35e3ee4357b1dc00f
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TBX4 F2RL1 ABCC6 SLC16A4 CTSW	4.27e-05	119	144	5	8a3f0a3ed9f80d7b061162e9fa519bb09804a86c
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cdkn2b_(Cdkn2b)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TBX4 F2RL1 ABCC6 SLC16A4 CTSW	4.27e-05	119	144	5	938da0fe90372709048bf4e5503cc1cbf8376b17
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A	TPP2 PTDSS2 NEB GSK3A ABHD4 DUSP10 FGD6 PCM1 ZMYM6	4.40e-06	194	145	9	3431_DN
Drug	Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A	DENND1C NEB GSK3A RYR1 EHD2 SLC10A1 MED25 BAIAP3 TBX5	4.59e-06	195	145	9	2225_UP
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; MCF7; HT_HG-U133A	ASIC1 LAMA4 MAST2 DICER1 CLEC4E RNASEL PCM1 KDM4B TBX5	4.78e-06	196	145	9	3965_DN
Drug	troglitazone; Down 200; 10uM; MCF7; HT_HG-U133A_EA	NSD2 JADE1 MAST2 DICER1 RLF THBS1 PPP2R3A DNA2 PCM1	5.19e-06	198	145	9	1070_DN
Drug	Pentolinium bitartrate [52-62-0]; Up 200; 7.4uM; HL60; HT_HG-U133A	NEMP1 ASIC1 TRPC3 CASP8 NEB MAST2 PBRM1 VCAN AP3D1	5.41e-06	199	145	9	2343_UP
Drug	prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT_HG-U133A	TRIM2 ASIC1 F2RL1 PPP2R3A CARD9 VPS13A CDC42EP2 ZMYM6	1.99e-05	179	145	8	1640_UP
Drug	1,2,5,6-dibenzanthracene	CYP1B1 TBX4 TRIM2 LAMA4 RECQL IRS1 CYP2S1 THBS1 PIEZO2 PTX3 VPS13A NQO1 SLC39A14 POLK IRX2 KIT IQGAP3	2.50e-05	837	145	17	ctd:C026486
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	DRD1 DICER1 GSK3A CLEC4E SLC10A1 SLC16A4 KIT TBX5	3.17e-05	191	145	8	3975_DN
Drug	Glipizide [29094-61-9]; Down 200; 9uM; PC3; HG-U133A	BAZ2B WWP1 RECQL DICER1 DMXL1 SMARCC2 DNA2 PCM1	3.41e-05	193	145	8	1926_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 1uM; MCF7; HT_HG-U133A	HNF1B DRD1 ASIC1 GSK3A CLEC4E SLC10A1 EHMT1 AP3D1	3.54e-05	194	145	8	3968_DN
Drug	Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	HNF1B ASIC1 LAMA4 EXT1 GSK3A SLC10A1 SLC16A4 TBX5	3.54e-05	194	145	8	3977_DN
Drug	arachidonyl trifluoromethyl ketone; Up 200; 10uM; MCF7; HG-U133A	CYP1B1 GSK3A PTOV1 VPS13A CDC42EP2 AP3D1 KDM4B KPNA1	3.67e-05	195	145	8	327_UP
Drug	AG-013608 [351320-38-2]; Up 200; 10uM; MCF7; HT_HG-U133A	NSD2 SLC10A1 MCTP1 PTX3 VCAN BAIAP3 KDM4B TBX5	3.81e-05	196	145	8	6435_UP
Drug	Mometasone furoate [83919-23-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A	DENND1C MAST2 GSK3A STK10 MED25 DUSP10 ZMYM6 TBX5	3.95e-05	197	145	8	5541_UP
Drug	Praziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	DRD1 ASIC1 NEB GSK3A CARD9 MED25 BAIAP3 PCM1	3.95e-05	197	145	8	7228_UP
Drug	S 125	CSN2 IL2	4.03e-05	2	145	2	CID000017579
Drug	Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; PC3; HT_HG-U133A	CYP1B1 HNF1B TRIM2 GSK3A MED25 DUSP10 PCM1 TBX5	4.09e-05	198	145	8	3785_DN
Drug	Deoxycorticosterone [64-85-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	NSD2 TRPC3 EXT1 DICER1 GSK3A VCAN EHMT1 DUSP10	4.09e-05	198	145	8	6476_UP
Drug	Chloropyramine hydrochloride [6170-42-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A	DOCK2 ASIC1 CASP8 GRIN1 PTX3 AVIL MED25 TBX5	4.09e-05	198	145	8	4414_UP
Drug	Hexamethonium dibromide dihydrate [55-97-0]; Up 200; 10uM; MCF7; HT_HG-U133A	EHD2 VCAN MED25 USP7 EHMT1 IL2 KIT BAIAP3	4.24e-05	199	145	8	1482_UP
Drug	Antipyrine [60-80-0]; Up 200; 21.2uM; HL60; HG-U133A	BAZ2B CASP8 MAST2 DMXL1 CARD9 PCM1 KDM4B KPNA1	4.24e-05	199	145	8	1989_UP
Drug	Bacitracin [1405-87-4]; Up 200; 2.8uM; MCF7; HT_HG-U133A	TRIM2 TRPC3 DENND1C CARD9 CIBAR1 IL2 KIT TBX5	4.39e-05	200	145	8	6488_UP
Drug	Methylhydantoin-5-(L) [40856-73-3]; Up 200; 35uM; MCF7; HT_HG-U133A	HNF1B TRIM2 LAMA4 DICER1 GSK3A THBS1 SLC10A1 MED25	4.39e-05	200	145	8	5679_UP
Drug	Enilconazole [35554-44-0]; Up 200; 13.4uM; MCF7; HT_HG-U133A	TRIM2 ASPN LAMA4 NEB CARD9 PTX3 VCAN TBX5	4.39e-05	200	145	8	6518_UP
Drug	Spermine	ASIC1 CASP8 NEB RYR1 NQO1	5.11e-05	63	145	5	ctd:D013096
Drug	Manganese	TRPC3 GRIN1 PARP14 ABCC6 PTX3 AP3B2 VPS13A NQO1 SLC39A14 SNX9 IL2 ZMYM6	6.03e-05	480	145	12	ctd:D008345
Disease	melanoma	CYP1B1 IQCH CASP8 F2RL1 KDM4A IL2 KIT KDM4B	2.07e-05	248	136	8	C0025202
Disease	primary immunodeficiency disease (is_implicated_in)	TPP2 CASP8 CARD9 IL2	4.22e-05	42	136	4	DOID:612 (is_implicated_in)
Disease	L2 Acute Lymphoblastic Leukemia	CYP1B1 NSD2 CASP8 NQO1	8.43e-05	50	136	4	C0023453
Disease	Childhood Acute Lymphoblastic Leukemia	CYP1B1 NSD2 CASP8 NQO1	9.84e-05	52	136	4	C0023452
Disease	Male Germ Cell Tumor	DICER1 KIT	1.26e-04	4	136	2	C3496549
Disease	urinary bladder cancer (is_marker_for)	CYP1B1 THBS1 KDM4A KIT KDM4B	1.41e-04	107	136	5	DOID:11054 (is_marker_for)
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	CYP1B1 NSD2 CASP8 NQO1	1.84e-04	61	136	4	C1961102
Disease	Prostate cancer, familial	DOCK2 HNF1B CASP8 RNASEL	2.96e-04	69	136	4	C2931456
Disease	renal cell carcinoma (is_implicated_in)	HNF1B PBRM1 IL2 KIT	2.96e-04	69	136	4	DOID:4450 (is_implicated_in)
Disease	MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE	NEB RYR1	3.13e-04	6	136	2	C1854678
Disease	Manic Disorder	CACNA1C DRD1 TRPC3 GSK3A	3.30e-04	71	136	4	C0024713
Disease	Bipolar Disorder	CACNA1C DRD1 TRPC3 CASP8 GRIN1 GSK3A PBRM1 ULK4 ASTN2	3.83e-04	477	136	9	C0005586
Disease	RENAL CELL CARCINOMA, NONPAPILLARY	HNF1B PBRM1	4.36e-04	7	136	2	144700
Disease	Nonpapillary renal cell carcinoma	HNF1B PBRM1	4.36e-04	7	136	2	cv:CN074294
Disease	Thymic Carcinoma	PBRM1 KIT	4.36e-04	7	136	2	C0205969
Disease	Manic	CACNA1C DRD1 TRPC3 GSK3A	4.73e-04	78	136	4	C0338831
Disease	Depression, Bipolar	CACNA1C DRD1 TRPC3 GSK3A	4.96e-04	79	136	4	C0005587
Disease	hippocampus molecular layer volume	VCAN ASTN2 WNK2	5.63e-04	35	136	3	EFO_0009397
Disease	Prostatic Neoplasms	CYP1B1 HNF1B NOX3 IRS1 KMT2C RNASEL NQO1 USP7 POLK IL2	5.91e-04	616	136	10	C0033578
Disease	Malignant neoplasm of prostate	CYP1B1 HNF1B NOX3 IRS1 KMT2C RNASEL NQO1 USP7 POLK IL2	5.91e-04	616	136	10	C0376358
Disease	orofacial cleft	ABCA4 SHTN1 FMN1	6.63e-04	37	136	3	MONDO_0000358
Disease	acoustic startle blink response measurement	CACNA1C PARP14	7.43e-04	9	136	2	EFO_0006875
Disease	Schizophrenia	CACNA1C DRD1 SHMT1 DICER1 GSK3A THBS1 PBRM1 ULK4 ASTN2 IL2 PCM1 KPNA1	8.18e-04	883	136	12	C0036341
Disease	Breast Carcinoma	CYP1B1 NSD2 SHMT1 CASP8 RECQL THBS1 PBRM1 NQO1 KIT	9.02e-04	538	136	9	C0678222
Disease	alopecia areata (is_marker_for)	KDM4A KDM4B	9.26e-04	10	136	2	DOID:986 (is_marker_for)
Disease	subiculum volume	VCAN ASTN2 WNK2	1.03e-03	43	136	3	EFO_0009399
Disease	3-hydroxypropylmercapturic acid measurement	SYNRG TRPC3 EXT1 STK10 MCTP1 ERCC6L2 TBX5	1.27e-03	352	136	7	EFO_0007014
Disease	Congenital myopathy (disorder)	NEB RYR1	1.35e-03	12	136	2	C0270960
Disease	Autistic Disorder	GPR155 CACNA1C DRD1 EXT1 ASTN2 IL2	1.36e-03	261	136	6	C0004352
Disease	Malignant neoplasm of breast	CYP1B1 ABCA4 NSD2 SHMT1 CASP8 RECQL THBS1 PBRM1 NQO1 EHMT1 ASTN2 LRBA KIT	1.42e-03	1074	136	13	C0006142
Disease	bipolar disorder	DOCK2 CACNA1C IQCH PBRM1 MCTP1 IL2 KIT WNK2 PUS7	1.46e-03	577	136	9	MONDO_0004985
Disease	hepatocellular carcinoma (is_implicated_in)	SF3B4 CASP8 RECQL DICER1 IL2	1.55e-03	181	136	5	DOID:684 (is_implicated_in)
Disease	male infertility (implicated_via_orthology)	CFAP47 KIT	1.59e-03	13	136	2	DOID:12336 (implicated_via_orthology)
Disease	pancreatic cancer (is_implicated_in)	CASP8 RECQL THBS1 IL2	1.83e-03	112	136	4	DOID:1793 (is_implicated_in)
Disease	Testicular Germ Cell Tumor	STK10 KIT	1.85e-03	14	136	2	C1336708
Disease	Hepatomegaly	GPR155 CYP1B1 CYBA	2.00e-03	54	136	3	C0019209
Disease	body weights and measures, body height	SF3B4 TBX4	2.13e-03	15	136	2	EFO_0004324, EFO_0004339
Disease	alcohol use disorder (implicated_via_orthology)	DRD1 SHMT1 RYR1 PBRM1 SMARCC2	2.14e-03	195	136	5	DOID:1574 (implicated_via_orthology)
Disease	red blood cell density measurement	CACNA1C PIEZO1 NOX3 RFC1 MAST2 ABCC6 PBRM1 FMN1 ULK4 KDM4A AP3D1	2.59e-03	880	136	11	EFO_0007978
Disease	PROSTATE CANCER, HEREDITARY, 1	DOCK2 CASP8 RNASEL	2.71e-03	60	136	3	C4722327
Disease	Sjogren's syndrome (implicated_via_orthology)	THBS1 IL2	2.74e-03	17	136	2	DOID:12894 (implicated_via_orthology)
Disease	heart disease (biomarker_via_orthology)	CASP8 THBS1	2.74e-03	17	136	2	DOID:114 (biomarker_via_orthology)
Disease	Malignant Neoplasms	DICER1 NQO1 IL2 KIT	2.96e-03	128	136	4	C0006826
Disease	nevus count	CYP1B1 FMN1	3.07e-03	18	136	2	EFO_0004632
Disease	squamous cell carcinoma (is_implicated_in)	KMT2C IL2	3.07e-03	18	136	2	DOID:1749 (is_implicated_in)
Disease	Mammary Carcinoma, Human	CYP1B1 NSD2 SHMT1 CASP8 RECQL THBS1 NQO1 KIT	3.08e-03	525	136	8	C4704874
Disease	Mammary Neoplasms, Human	CYP1B1 NSD2 SHMT1 CASP8 RECQL THBS1 NQO1 KIT	3.08e-03	525	136	8	C1257931
Disease	chronic obstructive pulmonary disease (is_implicated_in)	F2RL1 NQO1 CYBA	3.11e-03	63	136	3	DOID:3083 (is_implicated_in)
Disease	Mammary Neoplasms	CYP1B1 NSD2 SHMT1 CASP8 RECQL THBS1 NQO1 KIT	3.15e-03	527	136	8	C1458155
Disease	inferior parietal cortex volume measurement	TBC1D15 SHTN1	3.43e-03	19	136	2	EFO_0010307
Disease	myocardial infarction (implicated_via_orthology)	CYP1B1 RYR1 TBX5	3.55e-03	66	136	3	DOID:5844 (implicated_via_orthology)
Disease	end stage renal disease (implicated_via_orthology)	DRD1 IRS1	3.79e-03	20	136	2	DOID:783 (implicated_via_orthology)
Disease	lung non-small cell carcinoma (is_implicated_in)	NSD2 KMT2C PBRM1 NQO1	3.98e-03	139	136	4	DOID:3908 (is_implicated_in)
Disease	Bladder Neoplasm	KMT2C NQO1 USP7 IL2	4.08e-03	140	136	4	C0005695
Disease	palmitoylcarnitine measurement	FAM47B ASTN2	4.18e-03	21	136	2	EFO_0021044
Disease	bipolar I disorder	CACNA1C PBRM1 ASTN2 IL2	4.19e-03	141	136	4	EFO_0009963
Disease	Malignant neoplasm of urinary bladder	KMT2C NQO1 USP7 IL2	4.19e-03	141	136	4	C0005684
Disease	Contact Dermatitis	CYP1B1 CASP8 NQO1	4.35e-03	71	136	3	C0011616
Disease	Contact hypersensitivity	CYP1B1 CASP8 NQO1	4.35e-03	71	136	3	C0162351

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLLLSRGKTYMCKEP	ACCSL	511	Q4AC99
KALGFIKMKSYPSST	AVIL	311	O75366
KTFGKMKPRYEINSL	VCAN	3306	P13611
FGDGYIVTMKIKSPK	ABCA4	2161	P78363
LGIKMTVRYGKFLSL	TBC1D32	1011	Q96NH3
VMIARLKPSTIKKFY	BTBD16	201	Q32M84
KAPTYALKVSVMRAK	BAIAP3	191	O94812
GYKKVIKKPMDFSTI	BAZ2B	2096	Q9UIF8
GLFYAQKSKKPLMVI	AGR3	51	Q8TD06
KEAQSKRGMLTLKYP	POTEKP	56	Q9BYX7
ISYLKKEMPSVFGKE	EHD2	311	Q9NZN4
STGKKVKMQRPDSYV	ABHD4	296	Q8TB40
YERKMTPKAAFILIS	DRD1	131	P21728
LYRLGKKKGLPSRMV	DICER1	1356	Q9UPY3
PAVKNMYRSAKSGLK	DENND1C	446	Q8IV53
YKKVTGKEPARVFSM	CARD9	91	Q9H257
MPKVIKKTRPFYRAS	DMXL1	1881	Q9Y485
VPKMKKSLYSAISLF	ASPN	336	Q9BXN1
GSKKELKSMPFITYL	ASTN2	941	O75129
SIKRRGMFEPYLKSF	AP3B2	366	Q13367
SHTKPYIRKKAVLIM	AP3D1	156	O14617
SPRQKSMKGFYFAKL	RANBP2	21	P49792
MYIKPSAKDRVSLSK	OR6C1	256	Q96RD1
AMKQYLPTKRVRFGL	PGBD4	261	Q96DM1
SPRQKSMKGFYFAKL	RGPD5	21	Q99666
SPRQKSMKGFYFAKL	RGPD8	21	O14715
KSFETTVRYFGMKPK	FMN1	1326	Q68DA7
ATHLMYSPKAIKRIK	IQCH	551	Q86VS3
RNIVKKFLMYGSKPQ	PUM3	216	Q15397
PSKQYGLKMKTSRAF	PA2G4	251	Q9UQ80
MRKKKKVSLGPVSYV	PNMA8A	361	Q86V59
LSRKSGISPKKSKYM	PBRM1	641	Q86U86
KKSEMLQLFPAYLKG	KMT2C	4646	Q8NEZ4
KFRLGHQKYKSKIMP	MCTP1	496	Q6DN14
YLMLKDYTKVPIKRS	MAGED1	481	Q9Y5V3
PKAGIMIKSVKRAYH	KIT	166	P10721
ALFYLGLTMVGKIKR	GPR155	256	Q7Z3F1
MTDAYKFVKGKRPII	DUSP10	431	Q9Y6W6
GLMRLSKKYGPVFTI	CYP2S1	56	Q96SQ9
LLEYPRGKRKKGSTM	CYBA	51	P13498
KYMTAVVKLFGPFTR	CYBA	71	P13498
LGFTVGRYLAKKKMR	ECPAS	756	Q5VYK3
KSYMKFLKKILARDP	PCM1	251	Q15154
TTLPKMIFSYLSGKK	OR2M4	76	Q96R27
AAMSKLKSRYLKPSQ	OR4K15	296	Q8NH41
ILSKFMPKKSPIYVI	NEMP1	206	O14524
SPEIKLKITKTYMNG	NSD2	121	O96028
LKITKTYMNGKPLFE	NSD2	126	O96028
YRMPGVIEKLFAKKG	FAM47B	601	Q8NA70
KMTLISPLMLKKYGI	KDM4A	241	O75164
HKMTLISPIILKKYG	KDM4B	241	O94953
KAMGYFLKHLAPKRK	LRBA	741	P50851
SSKKKIFMGLIPYDQ	MED25	516	Q71SY5
SDVRKVGYLRKPKSM	IRS1	11	P35568
VMTRLASYLKKLPFE	PPP2R3A	281	Q06190
PYGMRYVAKVLKATL	IQGAP3	1141	Q86VI3
YPTKGEKIMLAIITK	IRX2	141	Q9BZI1
AMYDKGPFRSKKAVL	NQO1	131	P15559
LYSSKKKIFMGLIPY	PTOV1	206	Q86YD1
LKSKRPQYMRYVIKG	SLC10A1	176	Q14973
SLKEKMIISPGRYFL	PARP14	466	Q460N5
LFRTKKKHPAVIYMA	F2RL1	101	P55085
LTRMLTFKFYMPKKA	IL2	56	P60568
KAKLTIPILYVKVYM	GSK3A	211	P49840
MSTKVPIYLKRGSRK	CDC42EP2	1	O14613
MILKLIAFKPKGYFS	CACNA1C	1286	Q13936
AKFYESIMKILRPKP	DOCK2	1326	Q92608
KYMLVFKGKRYLTGI	EXT1	261	Q16394
GLSKKRKMYSEDKPL	FAM133B	176	Q5BKY9
VEPLKTYGTIVKMKR	CIBAR1	96	A1XBS5
MKPLQLYRKGVIKAT	CTSW	266	P56202
VPKAKDTVYTKGRVM	CSN2	101	P05814
RKFLMFIYKLSVSGP	DENND4C	326	Q5VZ89
TLDKVYQMKSKPRGY	CASP8	221	Q14790
IKVGPARKGSYKAKM	MAST2	1196	Q6P0Q8
AKMNFSYGLTIKPKS	CYP1B1	501	Q16678
SYTLEFIGKKSMSPK	CCDC168	2141	Q8NDH2
TLSDPKYSGKMKVLQ	ERCC6L2	511	Q5T890
KVRKMPVSYLGSKFL	CCDC8	126	Q9H0W5
RGYKTKYKIMPLELK	DNA2	286	P51530
KYKIMPLELKTGKES	DNA2	291	P51530
GASVVPFMKKTFYKR	SLC39A14	171	Q15043
KTHPMLRPYKTFSEK	RYR1	2786	P21817
TLITVGFKPKMYCRK	CFAP47	3096	Q6ZTR5
RRMGTYSLVPKKKTK	EHMT1	291	Q9H9B1
TAILFPMRSKKIFGS	PTX3	181	P26022
KAFTSLSLYMKPPVK	LAMA4	856	Q16363
MIFYRKGVKSVDPKT	SHMT1	266	P34896
KGTPMKTQKRAALYT	HNF1B	156	P35680
DPRKGSKMYGLKSYI	SNX9	256	Q9Y5X1
IAKLKSDGIPMYKRN	TES	76	Q9UGI8
KALPSMDKYAVFKGI	SYNRG	506	Q9UMZ2
ITKAGRRMFPSYKVK	TBX5	76	Q99593
GYLRMSPLFKAKMVL	ABCC6	61	O95255
LNLIRTMPGKKSKYE	RFC1	476	P35251
MTTPGKENFRLKSYK	KPNA1	1	P52294
SRQVPKSTKKGKYMA	NEXMIF	1216	Q5QGS0
MKIPSAGGKYKAFSI	OR7G3	226	Q8NG95
IPTYKGKMKRIAFQF	PTDSS2	281	Q9BVG9
RVKPNIFSYMGTKDK	PUS7	281	Q96PZ0
MKLKIGDPSLYFQKT	RNASEL	681	Q05823
KTFIGKIPIMLRSTY	POLR2B	146	P30876
TLKRISMLYMAKLGP	SHTN1	96	A0MZ66
SLMFIRPKKYIVSSG	JADE1	106	Q6IE81
KKRGFKMAPGQYILV	NOX3	311	Q9HBY0
GLRTDMYTKKNVPSK	SMARCC2	576	Q8TAQ2
LIVAGVALFMYKPKK	SLC35B1	146	P78383
RYTKGKLSMFVLLPS	SERPINB12	246	Q96P63
KYLVEFRAGKMSLKG	ADRM1	21	Q16186
RYGKELSMVKIPSKA	ASIC1	371	P78348
LSMVKIPSKASAKYL	ASIC1	376	P78348
FLSYKKPKMREFFIG	CLEC4E	126	Q9ULY5
SISSKLEGKIMPVKY	CNMD	151	O75829
LIYVTPEKIAKSKMF	RECQL	186	P46063
IKLKKLIGPHYYTMR	SLC7A14	531	Q8TBB6
PKTGFIRVVMYEGKK	THBS1	1116	P07996
MYNKSGGKVRLTFKL	UBFD1	221	O14562
KKFMHVLYPRKSNTL	YIPF6	71	Q96EC8
FMDVRMPKFKIYGKL	VPS13A	756	Q96RL7
YIMKRLTKENVKPSG	THOC2	551	Q8NI27
MLKREGKVQPYTKTL	SLC16A4	1	O15374
LKTYKPMGFESSFLK	RLF	1761	Q13129
KVKSYGQMIIPSREK	SRRM5	241	B3KS81
EMGSLSIKDPKLYKK	STK10	511	O94804
RIADIFVKKGPYLKM	FGD6	951	Q6ZV73
KAVTRTKRPGLMTKY	POLK	836	Q9UBT6
AKLIFLYRSPETMIK	PIEZO2	2731	Q9H5I5
VNKMYGRGLKFATKL	TPP2	1191	P29144
KYTITPVKMRKSGGR	MRPL2	71	Q5T653
DILYKLSSMKFKDPL	ATP6V1A	576	P38606
KKIKKDPYTATMIGF	TBC1D15	236	Q8TC07
LFATKPELLFYKGKM	ZMYM6	436	O95789
FKGDIKLSLPVYIMK	WDR93	271	Q6P2C0
AKLIFLYRSPETMIK	PIEZO1	2501	Q92508
KAGRRMFPSYKVKVT	TBX4	91	P57082
GTLKTYLKRFKVMKP	WNK2	281	Q9Y3S1
YLKRFKVMKPKVLRS	WNK2	286	Q9Y3S1
VKRPASMYSTGKRKE	TRIM2	451	Q9C040
TGFSLPFYKRMLSKK	WWP1	676	Q9H0M0
PFYKRMLSKKLTIKD	WWP1	681	Q9H0M0
NKYGKFLCRKPVFIM	ZNF382	271	Q96SR6
PKLFRGKMVSYIQCK	USP7	321	Q93009
GRKPGYKIKSRVLMT	SCML4	46	Q8N228
MIKLYGKPIRVNKAS	SF3B4	76	Q15427
PYLLTMAKKALKSES	TERF2	276	Q15554
SRLGKILRSPFMKFV	TRPC3	361	Q13507
LKKSMKSRVKGSPVY	ULK4	171	Q96C45
KKMGPIRSYLTFVLR	KIAA0319	91	Q5VV43
VIRKKVDPSKFMTPY	NEB	71	P20929
KTGPLFKRVLMSSKY	GRIN1	316	Q05586
KKKGLIPAYHRVIMA	NMNAT1	56	Q9HAN9