Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN3A SCN7A SCN8A	2.31e-06	26	73	4	GO:0005248
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN3A SCN8A	1.66e-05	14	73	3	GO:0031402
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN3A SCN7A SCN8A	3.90e-05	52	73	4	GO:0005272
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN3A SCN8A	1.15e-04	26	73	3	GO:0031420
GeneOntologyMolecularFunction	monoatomic cation channel activity	PIEZO2 SCN1A SCN3A CNGB3 SCN7A SCN8A PKDREJ	2.56e-04	343	73	7	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion channel activity	ANO2 PIEZO2 SCN1A SCN3A CNGB3 SCN7A SCN8A PKDREJ	2.67e-04	459	73	8	GO:0005216
GeneOntologyMolecularFunction	channel activity	ANO2 PIEZO2 SCN1A SCN3A CNGB3 SCN7A SCN8A PKDREJ	6.50e-04	525	73	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ANO2 PIEZO2 SCN1A SCN3A CNGB3 SCN7A SCN8A PKDREJ	6.58e-04	526	73	8	GO:0022803
GeneOntologyMolecularFunction	cytidine deaminase activity	APOBEC3B APOBEC3F	1.00e-03	13	73	2	GO:0004126
GeneOntologyBiologicalProcess	heart contraction	SEMA3A SCN1A SCN3A SCN7A SCN8A MDM4 CHRM3 SMAD7	9.28e-06	298	72	8	GO:0060047
GeneOntologyBiologicalProcess	heart process	SEMA3A SCN1A SCN3A SCN7A SCN8A MDM4 CHRM3 SMAD7	1.21e-05	309	72	8	GO:0003015
GeneOntologyBiologicalProcess	blood circulation	SEMA3A SLIT2 KAT2B SCN1A SCN3A SCN7A SCN8A GCGR MDM4 CHRM3 SMAD7	1.43e-05	648	72	11	GO:0008015
GeneOntologyBiologicalProcess	circulatory system process	SEMA3A SLIT2 KAT2B SCN1A SCN3A SCN7A SCN8A GCGR MDM4 CHRM3 SMAD7	4.44e-05	733	72	11	GO:0003013
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN3A SCN7A SCN8A	6.53e-05	62	72	4	GO:0086002
GeneOntologyBiologicalProcess	membrane depolarization	RACK1 SCN1A SCN3A SCN8A SMAD7	6.54e-05	121	72	5	GO:0051899
GeneOntologyBiologicalProcess	clearance of foreign intracellular DNA	APOBEC3B APOBEC3F	1.79e-04	6	72	2	GO:0044355
GeneOntologyBiologicalProcess	clearance of foreign intracellular nucleic acids	APOBEC3B APOBEC3F	1.79e-04	6	72	2	GO:0099046
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN1A SCN3A SCN7A SCN8A	2.44e-04	87	72	4	GO:0086001
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN3A SCN8A	2.68e-04	36	72	3	GO:0086010
GeneOntologyBiologicalProcess	cardiac muscle contraction	SCN1A SCN3A SCN7A SCN8A SMAD7	2.96e-04	167	72	5	GO:0060048
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN1A SCN3A SCN7A SCN8A	3.15e-04	93	72	4	GO:0086003
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN3A SCN7A SCN8A	3.15e-07	17	73	4	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN3A SCN7A SCN8A	3.04e-06	29	73	4	GO:0034706
Domain	Na_channel_asu	SCN1A SCN3A SCN7A SCN8A	4.19e-08	10	72	4	IPR001696
Domain	Na_trans_assoc	SCN1A SCN3A SCN7A SCN8A	4.19e-08	10	72	4	IPR010526
Domain	Na_trans_assoc	SCN1A SCN3A SCN7A SCN8A	4.19e-08	10	72	4	PF06512
Domain	Na_trans_cytopl	SCN1A SCN3A SCN8A	1.09e-06	6	72	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN3A SCN8A	1.09e-06	6	72	3	IPR024583
Domain	C_TYPE_LECTIN_1	SELL CLEC4E CLEC4A MRC2 LY75	1.42e-05	80	72	5	PS00615
Domain	Lectin_C	SELL CLEC4E CLEC4A MRC2 LY75	1.80e-05	84	72	5	PF00059
Domain	CLECT	SELL CLEC4E CLEC4A MRC2 LY75	1.80e-05	84	72	5	SM00034
Domain	C_TYPE_LECTIN_2	SELL CLEC4E CLEC4A MRC2 LY75	1.91e-05	85	72	5	PS50041
Domain	C-type_lectin-like	SELL CLEC4E CLEC4A MRC2 LY75	2.02e-05	86	72	5	IPR001304
Domain	C-type_lectin_CS	SELL CLEC4A MRC2 LY75	2.24e-05	43	72	4	IPR018378
Domain	C-type_lectin-like/link	SELL CLEC4E CLEC4A MRC2 LY75	3.99e-05	99	72	5	IPR016186
Domain	CTDL_fold	SELL CLEC4E CLEC4A MRC2 LY75	5.79e-05	107	72	5	IPR016187
Domain	Channel_four-helix_dom	SCN1A SCN3A SCN7A SCN8A	6.87e-05	57	72	4	IPR027359
Domain	-	SCN1A SCN3A SCN7A SCN8A	6.87e-05	57	72	4	1.20.120.350
Domain	Ion_trans_dom	SCN1A SCN3A CNGB3 SCN7A SCN8A	7.84e-05	114	72	5	IPR005821
Domain	Ion_trans	SCN1A SCN3A CNGB3 SCN7A SCN8A	7.84e-05	114	72	5	PF00520
Domain	Sec23/24_helical_dom	SEC23B SEC23A	2.18e-04	6	72	2	IPR006900
Domain	Sec23_24_beta_S	SEC23B SEC23A	2.18e-04	6	72	2	IPR012990
Domain	zf-Sec23_Sec24	SEC23B SEC23A	2.18e-04	6	72	2	PF04810
Domain	Sec23_trunk	SEC23B SEC23A	2.18e-04	6	72	2	PF04811
Domain	Sec23_helical	SEC23B SEC23A	2.18e-04	6	72	2	PF04815
Domain	Sec23_BS	SEC23B SEC23A	2.18e-04	6	72	2	PF08033
Domain	Sec23/24_trunk_dom	SEC23B SEC23A	2.18e-04	6	72	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC23B SEC23A	2.18e-04	6	72	2	IPR006895
Domain	IQ	SCN1A SCN3A SCN7A SCN8A	2.70e-04	81	72	4	SM00015
Domain	IQ_motif_EF-hand-BS	SCN1A SCN3A SCN7A SCN8A	4.04e-04	90	72	4	IPR000048
Domain	-	SELL CLEC4E CLEC4A MRC2	5.37e-04	97	72	4	3.10.100.10
Domain	EF-hand-dom_pair	SCN1A SCN3A DEF6 SCN7A USP32 SCN8A	8.35e-04	287	72	6	IPR011992
Domain	APOBEC_N	APOBEC3B APOBEC3F	9.43e-04	12	72	2	PF08210
Domain	APOBEC_N	APOBEC3B APOBEC3F	9.43e-04	12	72	2	IPR013158
Domain	Gelsolin	SEC23B SEC23A	1.29e-03	14	72	2	PF00626
Domain	FN_type2_col-bd	MRC2 LY75	1.29e-03	14	72	2	IPR000562
Domain	FN2_2	MRC2 LY75	1.29e-03	14	72	2	PS51092
Domain	Gelsolin-like_dom	SEC23B SEC23A	1.29e-03	14	72	2	IPR007123
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3B APOBEC3F	1.29e-03	14	72	2	IPR016192
Domain	fn2	MRC2 LY75	1.29e-03	14	72	2	PF00040
Domain	FN2_1	MRC2 LY75	1.29e-03	14	72	2	PS00023
Domain	FN2	MRC2 LY75	1.29e-03	14	72	2	SM00059
Domain	CYT_DCMP_DEAMINASES_2	APOBEC3B APOBEC3F	1.49e-03	15	72	2	PS51747
Domain	Cytidine_deaminase-like	APOBEC3B APOBEC3F	1.92e-03	17	72	2	IPR016193
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3B APOBEC3F	1.92e-03	17	72	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3B APOBEC3F	1.92e-03	17	72	2	IPR002125
Domain	IQ	SCN1A SCN3A SCN8A	2.60e-03	71	72	3	PF00612
Domain	ADF-H/Gelsolin-like_dom	SEC23B SEC23A	3.83e-03	24	72	2	IPR029006
Domain	-	SEC23B SEC23A	3.83e-03	24	72	2	3.40.20.10
Domain	RICIN	MRC2 LY75	5.19e-03	28	72	2	SM00458
Domain	RICIN_B_LECTIN	MRC2 LY75	5.19e-03	28	72	2	PS50231
Domain	IQ	SCN1A SCN3A SCN8A	5.56e-03	93	72	3	PS50096
Domain	Ricin_B_lectin	MRC2 LY75	5.95e-03	30	72	2	IPR000772
Domain	Kringle-like	MRC2 LY75	6.75e-03	32	72	2	IPR013806
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN3A SCN7A SCN8A	5.20e-06	31	53	4	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN1A SCN3A SCN7A SCN8A	5.92e-06	32	53	4	M27455
Pathway	REACTOME_DECTIN_2_FAMILY	CLEC4E CLEC4A MUC4	1.23e-04	26	53	3	M27483
Pathway	REACTOME_CARDIAC_CONDUCTION	KAT2B SCN1A SCN3A SCN7A SCN8A	1.24e-04	130	53	5	M27454
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN3A SCN8A	1.54e-04	28	53	3	M45519
Pathway	REACTOME_MRNA_EDITING_C_TO_U_CONVERSION	APOBEC3B APOBEC3F	2.88e-04	7	53	2	MM15412
Pathway	REACTOME_MRNA_EDITING	APOBEC3B APOBEC3F	4.91e-04	9	53	2	MM15445
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN3A SCN8A	3.69e-08	4	74	3	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN3A SCN8A	3.69e-08	4	74	3	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN3A SCN8A	3.69e-08	4	74	3	29578003
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN3A SCN8A	1.84e-07	6	74	3	23652591
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN3A SCN8A	7.70e-07	9	74	3	16382098
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN3A SCN8A	7.70e-07	9	74	3	15746173
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN3A SCN8A	2.01e-06	12	74	3	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN3A SCN8A	2.60e-06	13	74	3	15123669
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN3A SCN7A	4.13e-06	15	74	3	9726281
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	4.47e-06	2	74	2	37901435
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	4.47e-06	2	74	2	26410685
Pubmed	Transcription of the human sodium channel SCN1A gene is repressed by a scaffolding protein RACK1.	RACK1 SCN1A	4.47e-06	2	74	2	24436055
Pubmed	Cloning and functional characterization of mammalian homologues of the COPII component Sec23.	SEC23B SEC23A	4.47e-06	2	74	2	8898360
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	4.47e-06	2	74	2	24990319
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	4.47e-06	2	74	2	33411788
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	4.47e-06	2	74	2	31943325
Pubmed	Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.	SEC23B SEC23A	4.47e-06	2	74	2	30065114
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	4.47e-06	2	74	2	27690330
Pubmed	Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease.	KAT2B SMAD7	4.47e-06	2	74	2	16285943
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	4.47e-06	2	74	2	23965409
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	4.47e-06	2	74	2	37665666
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	4.47e-06	2	74	2	17881658
Pubmed	Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope.	PIEZO2 APOBEC3B APOBEC3F	7.37e-06	18	74	3	37914931
Pubmed	Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	32641479
Pubmed	APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	27602762
Pubmed	A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	22691411
Pubmed	Studies on the restriction of murine leukemia viruses by mouse APOBEC3.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	22666481
Pubmed	APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	24577894
Pubmed	APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	16648136
Pubmed	Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	23533681
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN3A	1.34e-05	3	74	2	12610651
Pubmed	Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	1541833
Pubmed	In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	27356895
Pubmed	IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	23315078
Pubmed	Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	25589647
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A	1.34e-05	3	74	2	33895391
Pubmed	Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	23671100
Pubmed	Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	31518043
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN3A	1.34e-05	3	74	2	23859570
Pubmed	APOBEC3 signature mutations in chronic lymphocytic leukemia.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	24840555
Pubmed	Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	9765497
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN3A	1.34e-05	3	74	2	18784617
Pubmed	Dynamic regulation of TFH selection during the germinal centre reaction.	SELL LY75	1.34e-05	3	74	2	33536617
Pubmed	Biochemical and biological studies of mouse APOBEC3.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	24453360
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN3A	1.34e-05	3	74	2	17544618
Pubmed	APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	23449789
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN8A	1.34e-05	3	74	2	32845893
Pubmed	APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	18434399
Pubmed	Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	19153238
Pubmed	Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	18772436
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN8A	1.34e-05	3	74	2	28518218
Pubmed	GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.	SCN1A SCN3A	1.34e-05	3	74	2	27816501
Pubmed	Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	18786991
Pubmed	Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.	SCN1A SCN8A	1.34e-05	3	74	2	24704313
Pubmed	Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	286744
Pubmed	Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	24725948
Pubmed	The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	20702647
Pubmed	Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	20980520
Pubmed	Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	284359
Pubmed	The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.	SCN1A SCN8A	1.34e-05	3	74	2	28117367
Pubmed	Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	20617165
Pubmed	Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	31801862
Pubmed	Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	39208378
Pubmed	Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	31943071
Pubmed	Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	20566830
Pubmed	APOBEC-mediated viral restriction: not simply editing?	APOBEC3B APOBEC3F	1.34e-05	3	74	2	17303427
Pubmed	Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	7884913
Pubmed	N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	25505062
Pubmed	Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	31595054
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN8A	1.34e-05	3	74	2	17928448
Pubmed	Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	17967065
Pubmed	Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	20335265
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN3A	1.34e-05	3	74	2	14973256
Pubmed	Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	29593034
Pubmed	Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	31830125
Pubmed	Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	21998583
Pubmed	Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	38115583
Pubmed	Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity.	KAT2B KLF13	1.34e-05	3	74	2	12758070
Pubmed	Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.	SCN1A SCN8A	1.34e-05	3	74	2	26182346
Pubmed	Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	2157836
Pubmed	Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	35458563
Pubmed	Natural resistance to HIV infection: The Vif-APOBEC interaction.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	17067930
Pubmed	Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	22275865
Pubmed	De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.	SCN1A SCN8A	1.34e-05	3	74	2	31054517
Pubmed	Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	293683
Pubmed	Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	19150103
Pubmed	Initial sequencing and comparative analysis of the mouse genome.	APOBEC3B APOBEC3F	1.34e-05	3	74	2	12466850
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	USP9X SEC23B SEC23A	1.38e-05	22	74	3	35120648
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	PPP6C USP9X EIF3D SEC23B SEC23A	1.95e-05	153	74	5	26365490
Pubmed	Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	18983852
Pubmed	APOBEC3 regulates keratinocyte differentiation and expression of Notch3.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	31400166
Pubmed	Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	23725696
Pubmed	APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	21985787
Pubmed	APOBEC3A functions as a restriction factor of human papillomavirus.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	25355878
Pubmed	Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	26253512
Pubmed	Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	17020885
Pubmed	Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	20375169
Pubmed	APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	21147467
Pubmed	Mice deficient in APOBEC2 and APOBEC3.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	16055735
Pubmed	The incorporation of APOBEC3 proteins into murine leukemia viruses.	APOBEC3B APOBEC3F	2.67e-05	4	74	2	18572219
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	SCN1A SCN3A SCN7A LY75	5.53e-05	127	74	4	chr2q24
Cytoband	2q24	SCN3A LY75	1.40e-04	11	74	2	2q24
Cytoband	Xq25	TENM1 TEX13D	2.02e-03	41	74	2	Xq25
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN3A SCN8A	1.55e-06	9	49	3	1203
GeneFamily	C-type lectin domain family	CLEC4E CLEC4A MRC2 LY75	7.79e-06	47	49	4	494
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3B APOBEC3F	4.67e-04	12	49	2	406
GeneFamily	Immunoglobulin like domain containing	SEMA3A KIRREL3 EMB IL18BP	1.83e-03	193	49	4	594
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 SLIT2 SCN3A SCN7A SPIRE1 PKDREJ CHRM3	1.36e-08	169	74	7	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KIRREL3 KAT2B RNF125 EMB FGFBP2 SMAD7	4.42e-07	173	74	6	36a471576a9d2325066bb14c2f2cd89c67b92915
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	6.75e-07	186	74	6	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SLIT2 KIRREL3 MRC2 AOX1 SCN7A ABCA9	6.97e-07	187	74	6	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLIT2 FMO1 PIEZO2 MRC2 AOX1 ABCA9	8.13e-07	192	74	6	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLIT2 FMO1 PIEZO2 AOX1 SCN7A ABCA9	8.38e-07	193	74	6	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	SLIT2 KIRREL3 MRC2 AOX1 SCN7A ABCA9	8.90e-07	195	74	6	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	8.90e-07	195	74	6	df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	8.90e-07	195	74	6	4243190ad291d56694e2155954dbaa879c9d3844
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	9.17e-07	196	74	6	42e9828222a9663525d571633e8a454c30bfa7f8
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	9.17e-07	196	74	6	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	9.73e-07	198	74	6	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	9.73e-07	198	74	6	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	cellseq-Mesenchymal-Fibroblastic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	8978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCell	Biopsy_Other_PF-Mesenchymal-Fibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SLIT2 FMO1 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	9996b6887cf2b1936e10a1aa396f09fd8da5f4c4
ToppCell	distal-2-mesenchymal-Alveolar_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	12b705dabec1b3752a488a891eda1a5123fcdc41
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	2e4ab7fbd94d3d865ef6188d3b4916d2bf1b8d89
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	6e3d1ae0ef84d3075afa40129a41169996462672
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 FMO1 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	44317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 MRC2 AOX1 SCN7A TENM1 ABCA9	1.03e-06	200	74	6	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	Biopsy_IPF-Mesenchymal-Fibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	SLIT2 FMO1 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	d8637f1e62d3fb9476dc51e1b1dc2f4b14b5fcd8
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 PIEZO2 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	cellseq2-Mesenchymal-Fibroblastic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 FMO1 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	1c10597edd532bf172ca09870a937d35e2585081
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 MRC2 AOX1 SCN7A TENM1 ABCA9	1.03e-06	200	74	6	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 FMO1 MRC2 AOX1 SCN7A ABCA9	1.03e-06	200	74	6	440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCell	Control-PLT_5\|World / Disease Group and Platelet Clusters	SLIT2 RACK1 CNGB3 AOX1 SCN7A	2.19e-06	126	74	5	4ba753c4e83eb1d41964edfa22135e047f06c481
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8\|TCGA-Thymus / Sample_Type by Project: Shred V9	SLIT2 PIEZO2 MRC2 SCN1A SCN7A	5.33e-06	151	74	5	5906562efd36fbcb91f96e0a0d3a8fe999ba1e79
ToppCell	normal_Lung-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	RNF125 SCN3A TENM1 IGFLR1 ZNF572	5.86e-06	154	74	5	835ef49d314ecbcbfd8d1041ba202a5eedcda0bd
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL CLEC4E KIRREL3 EMB USP32	7.96e-06	164	74	5	8e6dbddacd56a07769163813e3ebfad13302bb62
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	SLIT2 KIRREL3 MRC2 SCN7A ABCA9	9.21e-06	169	74	5	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.15e-05	177	74	5	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X CNGB3 GCGR MUC4 DENND4C	1.18e-05	178	74	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	SELL PIEZO2 AOX1 SCN7A ABCA9	1.22e-05	179	74	5	e4224b2e9c4ae7da62cf670adf811f4112c7d060
ToppCell	LA-01._Fibroblast_I\|LA / Chamber and Cluster_Paper	SLIT2 MRC2 AOX1 SCN7A ABCA9	1.22e-05	179	74	5	dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.32e-05	182	74	5	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic-Neutrophil\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SELL ARMH2 CLEC4E CLEC4A ZDHHC19	1.32e-05	182	74	5	1932d77491d6d46278f01fd70eb469ef1b356619
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SELL ARMH2 CLEC4E CLEC4A ZDHHC19	1.35e-05	183	74	5	cfbf8539104cef9ca830ad4f6bb278746f7078f7
ToppCell	cellseq2-Immune-Hematopoietic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SELL ARMH2 CLEC4E CLEC4A ZDHHC19	1.35e-05	183	74	5	324ec4374b552da7ce03809945b3a0798342d4ba
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLIT2 KIRREL3 MRC2 SCN7A ABCA9	1.43e-05	185	74	5	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	Control-T_cells-NK_cells\|Control / group, cell type (main and fine annotations)	KAT2B RNF125 EMB FGFBP2 DGKK	1.43e-05	185	74	5	755c0998c729f462399f1d5e88adf4bfae31be30
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.62e-05	190	74	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SELL RNF125 EMB DEF6 TENM1	1.66e-05	191	74	5	133864ec1e89f97a82c3bb01d2a3c658397fefaf
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLIT2 MRC2 SCN7A TENM1 ABCA9	1.66e-05	191	74	5	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SLIT2 MRC2 AOX1 SCN7A ABCA9	1.66e-05	191	74	5	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLIT2 MRC2 SCN7A TENM1 ABCA9	1.66e-05	191	74	5	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.66e-05	191	74	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SELL RNF125 EMB DEF6 TENM1	1.70e-05	192	74	5	69a2b04f03a1b82d067018379f7b8a116e954040
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	SLIT2 MRC2 AOX1 SCN7A ABCA9	1.70e-05	192	74	5	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.70e-05	192	74	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SLIT2 ANO2 MRC2 SCN7A ABCA9	1.70e-05	192	74	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.70e-05	192	74	5	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	SLIT2 PIEZO2 MRC2 AOX1 ABCA9	1.70e-05	192	74	5	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.75e-05	193	74	5	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	SLIT2 MRC2 AOX1 SCN7A ABCA9	1.75e-05	193	74	5	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.79e-05	194	74	5	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	SLIT2 KIRREL3 MRC2 SCN7A ABCA9	1.79e-05	194	74	5	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RNF125 EMB FGFBP2 TENM1 SMAD7	1.79e-05	194	74	5	866a9ca4c93c3c79c709a9d00def5392197f7e18
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	SLIT2 MRC2 AOX1 SCN7A ABCA9	1.79e-05	194	74	5	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 AOX1 ABCA9	1.84e-05	195	74	5	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	PBMC\|World / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SELL RNF125 RACK1 EMB FGFBP2	1.84e-05	195	74	5	8cd7667a65d77dd7b301090a9b65aba254741375
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	SLIT2 MRC2 AOX1 SCN7A ABCA9	1.84e-05	195	74	5	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	PBMC\|World / Location, Disease Group, Cell group, Cell class (2021.03.09)	SELL RNF125 RACK1 EMB FGFBP2	1.84e-05	195	74	5	211eba45a502b961873ca2d4642f7852e6e89d7a
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.84e-05	195	74	5	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	PCW_07-8.5-Mesenchymal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SEMA3A SLIT2 PIEZO2 MRC2 SCN7A	1.88e-05	196	74	5	8e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.88e-05	196	74	5	9737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.88e-05	196	74	5	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.88e-05	196	74	5	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.93e-05	197	74	5	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	PCW_13-14-Mesenchymal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SEMA3A SLIT2 PIEZO2 MRC2 SCN7A	1.93e-05	197	74	5	73a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.93e-05	197	74	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.93e-05	197	74	5	13896ec65ccda0b928c91d41112dc01b480036b7
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	1.98e-05	198	74	5	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.98e-05	198	74	5	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	1.98e-05	198	74	5	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	2.02e-05	199	74	5	28c1722deef3b8347371c7359be7c64b95780de3
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	2.02e-05	199	74	5	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	PCW_10-12-Mesenchymal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SEMA3A SLIT2 PIEZO2 MRC2 SCN7A	2.02e-05	199	74	5	a09292de4c4447b8eee55d401808e43b817321cc
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	2.02e-05	199	74	5	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLIT2 FMO1 MRC2 AOX1 ABCA9	2.07e-05	200	74	5	0b2614b8513693dd508c9003699049efd9abac52
ToppCell	medial-mesenchymal-Alveolar_Fibroblast\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	2.07e-05	200	74	5	c22cbfecee00183dd4be678f116ab9fd9ad0a4dd
ToppCell	Bronchial-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 MRC2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	5ea12e17f50fefbf5534e487af3392b2fa2d13ad
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FMO1 PIEZO2 MRC2 SCN7A ABCA9	2.07e-05	200	74	5	c3d4ce70ab51d74c9fe2f5864e52a4a9d7570e10
ToppCell	normal_Lung-Fibroblasts\|normal_Lung / Location, Cell class and cell subclass	SLIT2 MRC2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	803cf7f1382d07220249029cd220233232027689
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	3'-Parenchyma_lung-Mesenchymal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 MRC2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	ba5ed66b05caa1be0bbf8d54c4e72a782b8d9833
ToppCell	wk_20-22-Mesenchymal-Fibroblast-intermediate_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SLIT2 FMO1 PIEZO2 MRC2 SCN7A	2.07e-05	200	74	5	d769723f8fcb37d9b86589e0c41c1d7f16393cfe
ToppCell	medial-2-mesenchymal-Alveolar_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	2.07e-05	200	74	5	cc6062dac07916c29091fc6bee2b864d29e6525b
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FMO1 PIEZO2 MRC2 SCN7A ABCA9	2.07e-05	200	74	5	137f8f9d255c66336d4f8b44b2e3f3de721f2bf0
ToppCell	proximal-mesenchymal-Adventitial_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 MRC2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	58c5870030192b337e7d883044948634fcd17d2c
ToppCell	proximal-mesenchymal-Adventitial_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 MRC2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	05486d86868f6a93429226063cca270f00dd8714
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLIT2 FMO1 MRC2 AOX1 ABCA9	2.07e-05	200	74	5	8d2ceb2080c67b20f452eeca605aa27a58033c04
ToppCell	medial-mesenchymal-Alveolar_Fibroblast-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 PIEZO2 MRC2 SCN7A ABCA9	2.07e-05	200	74	5	5c0716bf375c8158f7dc2c82bf5eaf37af594dd0
ToppCell	proximal-3-mesenchymal-Adventitial_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 MRC2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	869d45b71efd395d050873db5fee2ed0443d5e6f
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 MRC2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	6316c288022719b9e6c4332c5cb9041e1188d0e8
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	FMO1 PIEZO2 MRC2 SCN7A ABCA9	2.07e-05	200	74	5	25d3865aa2ced11a5ed40013e83b47d942fdf582
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 PIEZO2 AOX1 SCN7A ABCA9	2.07e-05	200	74	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 FMO1 MRC2 AOX1 ABCA9	2.07e-05	200	74	5	5c6520dc4c4693827f6680651785680b5883afb8
ToppCell	distal-1-Hematologic-Natural_Killer\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELL RNF125 GTF3C1 EMB FGFBP2	2.07e-05	200	74	5	69756eba4b9b6cd5115aa7b76dfc36bb70097993
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN3A SCN7A SCN8A	6.39e-09	10	71	4	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN3A SCN7A SCN8A	6.39e-09	10	71	4	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN3A SCN7A SCN8A	1.50e-08	12	71	4	DOID:0060170 (implicated_via_orthology)
Disease	congenital dyserythropoietic anemia type II (implicated_via_orthology)	SEC23B SEC23A	5.71e-06	2	71	2	DOID:0111401 (implicated_via_orthology)
Disease	craniolenticulosutural dysplasia (implicated_via_orthology)	SEC23B SEC23A	5.71e-06	2	71	2	DOID:0070307 (implicated_via_orthology)
Disease	Roberts syndrome (implicated_via_orthology)	SEC23B SEC23A	3.41e-05	4	71	2	DOID:5325 (implicated_via_orthology)
Disease	obsolete_red blood cell distribution width	ARMH2 KLF13 DHX32 ZDHHC19 IGFLR1 MUC4 APOBEC3B PTTG1IP DENND4C SEC23B SMAD7	3.55e-04	1347	71	11	EFO_0005192
Disease	epilepsy (implicated_via_orthology)	SCN1A SCN3A SCN7A SCN8A	6.54e-04	163	71	4	DOID:1826 (implicated_via_orthology)
Disease	liver cirrhosis (is_marker_for)	IL18BP ADAMTS13 SMAD7	1.03e-03	82	71	3	DOID:5082 (is_marker_for)
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN3A	1.28e-03	22	71	2	DOID:2030 (implicated_via_orthology)
Disease	response to mTOR inhibitor	KAT2B USP32	1.65e-03	25	71	2	EFO_0005417

Protein segments in the cluster

Peptide	Gene	Start	Entry
VCAYWSQKSRCLYPG	BAHCC1	1981	Q9P281
FLSWFCGNQLPAYKC	APOBEC3B	71	Q9UH17
LLQSVACWCYLNPVS	ARMH2	121	H3BNL8
RCSPLFFLKSCFWFQ	ABCA9	431	Q8IUA7
WLCYINSTVNPVCYA	CHRM3	531	P20309
CSDRNWYVQPCCALT	ARL14	146	Q8N4G2
CPLCDKSCDYWNLSS	ANO2	411	Q9NQ90
PCLFESRTQFQYCNW	ANGEL2	81	Q5VTE6
KSAQVPQWCAEYCLS	DHX32	91	Q7L7V1
CPARWQYKLAACSVS	ADAMTS13	951	Q76LX8
NAYKFPNLRCRGWAC	AOX1	896	Q06278
INALCFSPNRYWLCA	RACK1	236	P63244
CCRWNDKPYLCALYQ	MUC4	4651	Q99102
SYQRLQDFRCLWCNS	DGKK	421	Q5KSL6
WTLSNLCRNKNPYPC	KPNA7	221	A9QM74
KFNSPSKRYCFRCWA	MDM4	311	O15151
NYTRWLCYCNVPQFC	KAT2B	281	Q92831
CVACSRFPNFSILYW	IL18BP	86	O95998
LVCNRTFDKYSCWPD	GCGR	56	P47871
VSDRCKDFSLCYWNP	GXYLT1	71	Q4G148
CWKPFQALCAFLISF	FGFBP2	206	Q9BYJ0
LWQSFSCEAQLPYVC	LY75	326	O60449
RNLSCYQCFKVSSWT	LY6L	26	H3BQJ8
KAALCYTASCQPWSC	SELL	151	P14151
WQNRDCSIALPYVCK	MRC2	346	Q9UBG0
SYNILRSPCCKNAWF	G2E3	156	Q7L622
NTLNLAPYDACWNAC	EIF2B3	271	Q9NR50
LSWFCGNQLPAYKCF	APOBEC3F	71	Q8IUX4
NALNSCDPWVQAKCY	HEATR5B	1891	Q9P2D3
KNNSYKLARWTCCAL	EIF3D	426	O15371
KPSWFGLCYCKALQS	FMO1	416	Q01740
YWNPDNKCCSSCLQR	IGFLR1	31	Q9H665
KRCYTNPPQWAKCLF	DENND4C	761	Q5VZ89
RWFQLQPSCLCYFGS	DEF6	236	Q9H4E7
CSAKANPAVTQYRWA	KIRREL3	271	Q8IZU9
PFACSWQDCNKKFAR	KLF13	196	Q9Y2Y9
AWQSSCYRPICGSRF	KRTAP13-4	141	Q3LI77
KCQNCFPLNWTWYSS	EMB	181	Q6PCB8
PECYLAACQKRDNWF	ZMYND8	256	Q9ULU4
ITLYGNLWNCSCSLF	LRRC19	171	Q9H756
LVGRVNAWSCCPFQY	FAM181A	266	Q8N9Y4
KLLRFCCWENPQFSS	USP9X	2301	Q93008
NCTNCASRDFYKWSI	PKDREJ	481	Q9NTG1
RILYSTWCPADCQFA	SH2D5	91	Q6ZV89
ARVSNWPLYCLFCFG	SGPP1	121	Q9BX95
TFNKPYRCCNWKCTA	TENM1	306	Q9UKZ4
ESRQKCPPCWYRFAN	SCN3A	721	Q9NY46
ECSPKSQRALVYWQF	SEMA3A	596	Q14563
AAPCYSLASRDKNWF	ODF3L1	176	Q8IXM7
CDYFPLLQLSCSDTW	OR6C3	176	Q9NZP0
NPLCQVDYRAKLWAC	SEC23A	71	Q15436
NPLCQVDYRAKLWAC	SEC23B	71	Q15437
RQKCPPCWYKFSNIF	SCN1A	731	P35498
CPKNWKSFSSNCYFI	CLEC4A	106	Q9UMR7
VKNCCPLNWEYFQSS	CLEC4E	76	Q9ULY5
TLAYNWNCCFIPLRL	CNGB3	226	Q9NQW8
PYRCSECWKTFSQSS	ZNF572	411	Q7Z3I7
CYTRQFISSCPCWLE	SMAD7	406	O15105
CKAINFSWRTACYKC	TEX13D	686	A0A0J9YY54
IATSLKNNKWTCPYC	RNF125	61	Q96EQ8
KNNKWTCPYCRAYLP	RNF125	66	Q96EQ8
KLVTVWSAPNYCYRC	PPP6C	251	O00743
TWSYTCQFCKRPVCS	SPIRE1	606	Q08AE8
WPKYCCFLACIITFQ	PIEZO2	1166	Q9H5I5
KPYRCQVCDTAFTWN	ZNF808	621	Q8N4W9
QRKCPPCWYKFANTF	SCN8A	716	Q9UQD0
SCLWCNTNKACLDYP	PTTG1IP	56	P53801
LLANPFNCNCYLAWL	SLIT2	661	O94813
YCGARWDQYKLCSTP	TSTD2	421	Q5T7W7
WDQYKLCSTPQCRQL	TSTD2	426	Q5T7W7
QGCASNWYLTICAPL	ZDHHC19	241	Q8WVZ1
YKFAKTFLIWNCSPC	SCN7A	476	Q01118
NYWFDLQCVCLNTPL	GTF3C1	1036	Q12789
PYACTQCGKAFRWKS	ZNF317	361	Q96PQ6
NFNLWACDYVPSCLD	TEX36	106	Q5VZQ5
AKNPNCKWYCYNDSS	USP32	1531	Q8NFA0
VYQFCSPSCWTKFQR	ZMYM3	566	Q14202