Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	PTPN4 PTPRG DNAJC6 PTK2	1.61e-04	103	53	4	GO:0004725
GeneOntologyMolecularFunction	DEAD/H-box RNA helicase binding	SMAD1 SMAD5	2.46e-04	9	53	2	GO:0017151
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD1 SMAD5	1.68e-04	8	52	2	GO:0071144
GeneOntologyCellularComponent	SMAD protein complex	SMAD1 SMAD5	2.70e-04	10	52	2	GO:0071141
GeneOntologyCellularComponent	nuclear inner membrane	FAM209A FAM209B SMAD1	4.28e-04	59	52	3	GO:0005637
Domain	FAM209	FAM209A FAM209B	7.90e-06	2	53	2	IPR027943
Domain	FAM209	FAM209A FAM209B	7.90e-06	2	53	2	PF15206
Domain	Dwarfin	SMAD1 SMAD5	2.19e-04	8	53	2	IPR013790
Domain	DWB	SMAD1 SMAD5	2.19e-04	8	53	2	SM00524
Domain	MH2	SMAD1 SMAD5	2.19e-04	8	53	2	PS51076
Domain	MH1	SMAD1 SMAD5	2.19e-04	8	53	2	PS51075
Domain	-	SMAD1 SMAD5	2.19e-04	8	53	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD5	2.19e-04	8	53	2	IPR013019
Domain	MH2	SMAD1 SMAD5	2.19e-04	8	53	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD5	2.19e-04	8	53	2	IPR001132
Domain	MAD_homology1_Dwarfin-type	SMAD1 SMAD5	5.12e-04	12	53	2	IPR003619
Domain	DWA	SMAD1 SMAD5	5.12e-04	12	53	2	SM00523
Domain	MH1	SMAD1 SMAD5	5.12e-04	12	53	2	PF03165
Domain	SMAD_dom-like	SMAD1 SMAD5	9.24e-04	16	53	2	IPR017855
Domain	-	SMAD1 SMAD5	9.24e-04	16	53	2	2.60.200.10
Domain	ALPHA_CA_2	PTPRG CA1	1.05e-03	17	53	2	PS51144
Domain	Carb_anhydrase	PTPRG CA1	1.05e-03	17	53	2	PF00194
Domain	Carb_anhydrase	PTPRG CA1	1.05e-03	17	53	2	SM01057
Domain	-	PTPRG CA1	1.05e-03	17	53	2	3.10.200.10
Domain	Carbonic_anhydrase_a	PTPRG CA1	1.05e-03	17	53	2	IPR001148
Domain	TYR_PHOSPHATASE_1	PTPN4 PTPRG DNAJC6	1.87e-03	86	53	3	PS00383
Domain	TYR_PHOSPHATASE_2	PTPN4 PTPRG DNAJC6	1.93e-03	87	53	3	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPN4 PTPRG DNAJC6	1.93e-03	87	53	3	IPR000387
Domain	TyrKc	FYN PTK2 PTK7	2.00e-03	88	53	3	SM00219
Domain	Tyr_kinase_cat_dom	FYN PTK2 PTK7	2.00e-03	88	53	3	IPR020635
Domain	-	PTPN4 PTPRG DNAJC6	2.27e-03	92	53	3	3.90.190.10
Domain	PROTEIN_KINASE_TYR	FYN PTK2 PTK7	2.64e-03	97	53	3	PS00109
Domain	Tyr_kinase_AS	FYN PTK2 PTK7	2.64e-03	97	53	3	IPR008266
Domain	Prot-tyrosine_phosphatase-like	PTPN4 PTPRG DNAJC6	2.79e-03	99	53	3	IPR029021
Domain	PTPc	PTPN4 PTPRG	4.68e-03	36	53	2	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPN4 PTPRG	5.47e-03	39	53	2	PS50055
Domain	-	PHYKPL GOT1	5.47e-03	39	53	2	3.40.640.10
Pathway	KEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY	SMAD1 SMAD5	1.40e-04	7	37	2	M47845
Pathway	KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY	SMAD1 SMAD5	1.86e-04	8	37	2	M47847
Pathway	REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	FYN PTK2	2.39e-04	9	37	2	MM15059
Pathway	KEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY	SMAD1 SMAD5	2.39e-04	9	37	2	M47844
Pathway	KEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY	SMAD1 SMAD5	2.39e-04	9	37	2	M47822
Pathway	PID_ALK2_PATHWAY	SMAD1 SMAD5	3.63e-04	11	37	2	M203
Pathway	KEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY	SMAD1 SMAD5	3.63e-04	11	37	2	M47848
Pathway	WP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION	SMAD1 SMAD5	5.13e-04	13	37	2	M39378
Pathway	REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	FYN PTK2	5.98e-04	14	37	2	M889
Pathway	WP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY	LAMB1 FYN PTK2	6.80e-04	66	37	3	MM15925
Pathway	REACTOME_NETRIN_1_SIGNALING	FYN PTK2	6.89e-04	15	37	2	MM14965
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	GALNT12 ADAMTS5 SMAD1 SMAD5	2.73e-07	36	53	4	25615642
Pubmed	Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.	LAMB1 SMAD1 SMAD5	1.85e-06	16	53	3	23153495
Pubmed	BMP signaling dynamics in embryonic orofacial tissue.	SMAD1 SMAD5	2.28e-06	2	53	2	18446813
Pubmed	Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization.	SMAD1 SMAD5	2.28e-06	2	53	2	21723296
Pubmed	Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro.	SMAD1 SMAD5	2.28e-06	2	53	2	24297369
Pubmed	BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.	SMAD1 SMAD5	2.28e-06	2	53	2	26711875
Pubmed	The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling.	SMAD1 SMAD5	2.28e-06	2	53	2	11451566
Pubmed	p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.	FYN PTK2	2.28e-06	2	53	2	8562954
Pubmed	The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.	FYN PTK2	2.28e-06	2	53	2	11278857
Pubmed	BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.	SMAD1 SMAD5	2.28e-06	2	53	2	32210087
Pubmed	BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow.	SMAD1 SMAD5	2.28e-06	2	53	2	23387849
Pubmed	Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.	SMAD1 SMAD5	2.28e-06	2	53	2	8799132
Pubmed	β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis.	PTK2 SMAD1 SMAD5	2.68e-06	18	53	3	28763805
Pubmed	ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.	ADAMTS5 SMAD1 SMAD5	3.74e-06	20	53	3	19922873
Pubmed	β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation.	LAMB1 SMAD1 SMAD5	5.04e-06	22	53	3	38794925
Pubmed	Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.	SMAD1 SMAD5	6.83e-06	3	53	2	10652350
Pubmed	Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.	SMAD1 SMAD5	6.83e-06	3	53	2	30953749
Pubmed	Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.	SMAD1 SMAD5	6.83e-06	3	53	2	32720893
Pubmed	TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.	SMAD1 SMAD5	6.83e-06	3	53	2	29376829
Pubmed	Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.	SMAD1 SMAD5	6.83e-06	3	53	2	21381028
Pubmed	Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.	SMAD1 SMAD5	6.83e-06	3	53	2	20371744
Pubmed	Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction.	FYN PTK2	6.83e-06	3	53	2	15494732
Pubmed	BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells.	SMAD1 SMAD5	6.83e-06	3	53	2	15246821
Pubmed	BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors.	SMAD1 SMAD5	6.83e-06	3	53	2	22964636
Pubmed	TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.	SMAD1 SMAD5	6.83e-06	3	53	2	25505291
Pubmed	Fluoride promotes viability and differentiation of osteoblast-like Saos-2 cells via BMP/Smads signaling pathway.	SMAD1 SMAD5	6.83e-06	3	53	2	23918166
Pubmed	Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.	SMAD1 SMAD5	6.83e-06	3	53	2	24023003
Pubmed	Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.	SMAD1 SMAD5	6.83e-06	3	53	2	27848974
Pubmed	Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.	SMAD1 SMAD5	6.83e-06	3	53	2	20522807
Pubmed	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	SMAD1 SMAD5	6.83e-06	3	53	2	31127639
Pubmed	Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.	SMAD1 SMAD5	6.83e-06	3	53	2	22897816
Pubmed	TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.	SMAD1 SMAD5	6.83e-06	3	53	2	19096363
Pubmed	NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn).	FYN PTK2	6.83e-06	3	53	2	9079653
Pubmed	BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling.	SMAD1 SMAD5	6.83e-06	3	53	2	33463047
Pubmed	Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.	SMAD1 SMAD5	6.83e-06	3	53	2	21945631
Pubmed	Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins.	SMAD1 SMAD5	6.83e-06	3	53	2	14711801
Pubmed	Molecular Interaction Between Smurfl WW2 Domain and PPXY Motifs of Smadl, Smad5, and Smad6-Modeling and Analysis.	SMAD1 SMAD5	6.83e-06	3	53	2	22670624
Pubmed	Gene expression profile of the mouse organ of Corti at the onset of hearing.	TECTB USH1C	6.83e-06	3	53	2	15177554
Pubmed	Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.	SMAD1 SMAD5	6.83e-06	3	53	2	30367512
Pubmed	Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line.	SMAD1 SMAD5	6.83e-06	3	53	2	25165122
Pubmed	Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage.	SMAD1 SMAD5	6.83e-06	3	53	2	12649288
Pubmed	Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation.	SMAD1 SMAD5	6.83e-06	3	53	2	25880873
Pubmed	Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.	SMAD1 SMAD5	6.83e-06	3	53	2	16247476
Pubmed	KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells.	FYN PTK2	6.83e-06	3	53	2	26786295
Pubmed	Msx1 is essential for proper rostral tip formation of the mouse mandible.	SMAD1 SMAD5	1.36e-05	4	53	2	36566565
Pubmed	Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus.	SMAD1 SMAD5	1.36e-05	4	53	2	19247629
Pubmed	A crucial role of a high mobility group protein HMGA2 in cardiogenesis.	SMAD1 SMAD5	1.36e-05	4	53	2	18425117
Pubmed	Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.	SMAD1 SMAD5	1.36e-05	4	53	2	23993924
Pubmed	Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6--modeling and analysis.	SMAD1 SMAD5	1.36e-05	4	53	2	17676934
Pubmed	SMAD Signaling Is Required for Structural Integrity of the Female Reproductive Tract and Uterine Function During Early Pregnancy in Mice.	SMAD1 SMAD5	1.36e-05	4	53	2	27335065
Pubmed	The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.	SMAD1 SMAD5	1.36e-05	4	53	2	15557274
Pubmed	The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo.	SMAD1 SMAD5	1.36e-05	4	53	2	23203803
Pubmed	Activation of FAK and Src are receptor-proximal events required for netrin signaling.	FYN PTK2	1.36e-05	4	53	2	15494734
Pubmed	Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.	SMAD1 SMAD5	1.36e-05	4	53	2	15107829
Pubmed	Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.	SMAD1 SMAD5	1.36e-05	4	53	2	17967875
Pubmed	Silencing of miR-330-5p stimulates osteogenesis in bone marrow mesenchymal stem cells and inhibits bone loss in osteoporosis by activating Bgn-mediated BMP/Smad pathway.	SMAD1 SMAD5	1.36e-05	4	53	2	32374006
Pubmed	Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response.	SMAD1 SMAD5	1.36e-05	4	53	2	26391659
Pubmed	Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.	SMAD1 SMAD5	1.36e-05	4	53	2	22452883
Pubmed	TGFβ signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis.	SMAD1 SMAD5	1.36e-05	4	53	2	25243859
Pubmed	Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.	SMAD1 SMAD5	1.36e-05	4	53	2	21239498
Pubmed	FAK-dependent regulation of myofibroblast differentiation.	FYN PTK2	1.36e-05	4	53	2	16585062
Pubmed	KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.	SMAD1 SMAD5	1.36e-05	4	53	2	25536014
Pubmed	Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.	SMAD1 SMAD5	1.36e-05	4	53	2	28401685
Pubmed	SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors.	SMAD1 SMAD5	1.36e-05	4	53	2	30188920
Pubmed	Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.	SMAD1 SMAD5	1.36e-05	4	53	2	18684712
Pubmed	Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells.	SMAD1 SMAD5	1.36e-05	4	53	2	19244313
Pubmed	Signal transduction of bone morphogenetic protein receptors.	SMAD1 SMAD5	1.36e-05	4	53	2	14687659
Pubmed	Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells.	SMAD1 SMAD5	1.36e-05	4	53	2	17359969
Pubmed	Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.	SMAD1 SMAD5	1.36e-05	4	53	2	28438754
Pubmed	Interaction of TGFβ and BMP signaling pathways during chondrogenesis.	SMAD1 SMAD5	1.36e-05	4	53	2	21297990
Pubmed	Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins.	FYN PTK2	1.36e-05	4	53	2	9750131
Pubmed	Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.	FYN PTK2	1.36e-05	4	53	2	9360983
Pubmed	Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK.	SMAD1 SMAD5	1.36e-05	4	53	2	24021264
Pubmed	Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.	SMAD1 SMAD5	1.36e-05	4	53	2	25755279
Pubmed	The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress.	SMAD1 SMAD5	1.36e-05	4	53	2	27483343
Pubmed	Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.	SMAD1 SMAD5	1.36e-05	4	53	2	34719843
Pubmed	Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.	TRAF3IP2 FYN	1.36e-05	4	53	2	34140493
Pubmed	Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1.	SMAD1 SMAD5	1.36e-05	4	53	2	28642261
Pubmed	Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.	SMAD1 SMAD5	1.36e-05	4	53	2	38246328
Pubmed	Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.	FYN SMAD1 SMAD5	1.93e-05	34	53	3	19956733
Pubmed	Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.	SMAD1 SMAD5	2.27e-05	5	53	2	27188281
Pubmed	Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.	SMAD1 SMAD5	2.27e-05	5	53	2	38703029
Pubmed	SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.	SMAD1 SMAD5	2.27e-05	5	53	2	25870111
Pubmed	Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.	SMAD1 SMAD5	2.27e-05	5	53	2	11121043
Pubmed	FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice.	FAM209A FAM209B	2.27e-05	5	53	2	34471926
Pubmed	Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway.	SMAD1 SMAD5	2.27e-05	5	53	2	27025722
Pubmed	Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.	SMAD1 SMAD5	2.27e-05	5	53	2	20651281
Pubmed	Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.	SMAD1 SMAD5	2.27e-05	5	53	2	18566469
Pubmed	The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.	SMAD1 SMAD5	2.27e-05	5	53	2	15647271
Pubmed	Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse.	SMAD1 SMAD5	2.27e-05	5	53	2	38300806
Pubmed	The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.	SMAD1 SMAD5	2.27e-05	5	53	2	29934521
Pubmed	Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors.	SMAD1 SMAD5	2.27e-05	5	53	2	19819941
Pubmed	Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells.	SMAD1 SMAD5	2.27e-05	5	53	2	16436528
Pubmed	Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.	SMAD1 SMAD5	2.27e-05	5	53	2	25141865
Pubmed	The TGFβ pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta.	SMAD1 SMAD5	2.27e-05	5	53	2	29253505
Pubmed	BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.	SMAD1 SMAD5	2.27e-05	5	53	2	26771354
Pubmed	Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.	SMAD1 SMAD5	2.27e-05	5	53	2	27612439
Pubmed	Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development.	SMAD1 SMAD5	2.27e-05	5	53	2	27890611
Pubmed	Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.	SMAD1 SMAD5	2.27e-05	5	53	2	30958854
Pubmed	Impaired SMAD1/5 Mechanotransduction and Cx37 (Connexin37) Expression Enable Pathological Vessel Enlargement and Shunting.	SMAD1 SMAD5	2.27e-05	5	53	2	32078368
Cytoband	20q13.31	FAM209A FAM209B	1.55e-04	16	53	2	20q13.31
Cytoband	6q27	C6orf118 CCR6	1.87e-03	55	53	2	6q27
GeneFamily	SMAD family	SMAD1 SMAD5	7.92e-05	8	31	2	750
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	PTPRG FYN PTK2 SMAD1 SMAD5	3.98e-06	200	53	5	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	PTPRG FYN PTK2 SMAD1 SMAD5	3.98e-06	200	53	5	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PTPRG FYN PTK2 SMAD1 SMAD5	3.98e-06	200	53	5	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	PTPRG LAMB1 ADAMTS5 FYN	4.87e-05	169	53	4	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B MFHAS1 OSBPL10 LAMB1	5.22e-05	172	53	4	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B MFHAS1 OSBPL10 LAMB1	5.22e-05	172	53	4	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN4 RTTN LAMB1 GOT1	5.96e-05	178	53	4	dfed0fbf7a73b8a9e00178ec58dc4592b271c344
ToppCell	LA-01._Fibroblast_I\|LA / Chamber and Cluster_Paper	PTPRG UGDH ADAMTS5 FYN	6.09e-05	179	53	4	dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPN4 MFHAS1 CCR6 FYN	6.23e-05	180	53	4	d9dae9db8e17f6990032ee6cfa8393fae4768ca5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-NK_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABHD17A PTPN4 LRRC43 FYN	6.50e-05	182	53	4	feda21c92d30848de70c8b404eaabbca3f5e894d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CATSPERE MFHAS1 AGPS FYN	7.07e-05	186	53	4	38f9f7d3b782978fd23b2a7fe565266285d39e44
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B ARSJ OSBPL10 LAMB1	7.07e-05	186	53	4	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG MFHAS1 OSBPL10 LAMB1	7.07e-05	186	53	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG MFHAS1 OSBPL10 LAMB1	7.22e-05	187	53	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG MFHAS1 OSBPL10 LAMB1	7.37e-05	188	53	4	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CATSPERE MFHAS1 AGPS FYN	7.37e-05	188	53	4	e35104ca327c2d9eb6ffed658051f62f855a0a0e
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RTTN OSBPL10 FYN SEZ6L	7.37e-05	188	53	4	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B PTPRG MFHAS1 OSBPL10	7.52e-05	189	53	4	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B PTPRG MFHAS1 OSBPL10	7.52e-05	189	53	4	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	RNF144B PTPRG SGK1 FYN	7.68e-05	190	53	4	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ARSJ IL1RAPL2 PRSS22	7.99e-05	70	53	3	8d6bdf2e773e894a0db39fdff1fafc2474e03fcf
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UGDH LAMB1 ADAMTS5 FYN	7.99e-05	192	53	4	30cefa0990ba1f379f350bfbf994a78db145075e
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPRG FYN PTK2 SMAD1	8.32e-05	194	53	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	PTPRG LAMB1 ADAMTS5 FYN	8.49e-05	195	53	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	IPF-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	RNF144B PTPRG SGK1 FYN	8.65e-05	196	53	4	8f0f72ead06abe02b575e443552eacc2151077ef
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UGDH LAMB1 ADAMTS5 FYN	8.65e-05	196	53	4	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	RNF144B PTPRG SGK1 FYN	8.83e-05	197	53	4	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-F\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	UGDH GALNT12 ADAMTS5 FYN	8.83e-05	197	53	4	fbff2fb7a8142b88c9dc71aa10980f4350b7e081
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B-B_intermediate\|Influenza_Severe / Disease, condition lineage and cell class	OSBPL10 CCR6 PTK2 AGBL3	9.00e-05	198	53	4	ab622fee61714471af3a7be0af356e8a484dcaff
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-gd_T\|Bac-SEP / Disease, condition lineage and cell class	ABHD17A PTPN4 PTPRG PRSS22	9.18e-05	199	53	4	29b2242be49a9640bfbae459edbfcc9f21d1a309
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PTPRG FYN SMAD1 SMAD5	9.36e-05	200	53	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-MAIT\|COVID-19_Severe / Disease, condition lineage and cell class	ABHD17A PTPN4 CCR6 FYN	9.36e-05	200	53	4	b8cfccecff9900aee323c40e771c94e560b8c488
ToppCell	control-MAIT\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ABHD17A PTPN4 CCR6 FYN	9.36e-05	200	53	4	aeea4bda2e38cc6db571ed2b47ce022d637619bd
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PTPRG FYN PTK2 SMAD1	9.36e-05	200	53	4	f15fffefe372005c33e31845982e2d2714ac26af
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PTPRG FYN PTK2 SMAD1	9.36e-05	200	53	4	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ARSJ PRSS22 LRRC43	3.93e-04	120	53	3	a6d0406a174d46ce06b41280292931954af88a59
ToppCell	\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NYNRIN ADAMTS5 LRRC43	4.03e-04	121	53	3	da8fe561dcf50792d0cbcaad383d564f900a6677
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col6a1_Fezf2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IL1RAPL2 PRSS22 ADAMTS5	4.13e-04	122	53	3	e96aec5af0ed1d8f4cc99fde59dd6998bbc1acbd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B AGPS AGBL3	5.67e-04	136	53	3	82b1d6d839c0d0c68e0960549f688138479defcc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTTN GALNT12 PTK7	5.91e-04	138	53	3	6b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-4\|TCGA-Cervix / Sample_Type by Project: Shred V9	C6orf118 CCR6 LRRC43	6.42e-04	142	53	3	369f2e51e0283a4de70e6c7a3b95672c0838f205
ToppCell	Control-Epithelial_alveolar-AT_1-AT2_Progenitor\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TGM1 PRSS22 TIGD5	6.42e-04	142	53	3	94e277f038f4006d99ff50222b0f5cf89bc3d46d
ToppCell	IIH-CD8-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	CAD LAMB1 SMAD1	6.96e-04	146	53	3	7fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCTD19 IL1RAPL2 SEZ6L	6.96e-04	146	53	3	40784fd7ef856f64edfb5a054c0c5d95c8150b20
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CHST10 TRMT11 SMAD5	6.96e-04	146	53	3	c0e1836845c083bf9d88a620da27acbfdea9fb20
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col18a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ARSJ IL1RAPL2 PRSS22	7.24e-04	148	53	3	fc80c02b51cf55a04ce550838ee2f41d8f656f41
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNT12 CCR6 DNAJC6	7.39e-04	149	53	3	efa30fcd9370f98eb7445f295eb4d0305ff455c3
ToppCell	RV-16._Neuronal\|World / Chamber and Cluster_Paper	IL1RAPL2 LAMB1 DNAJC6	7.39e-04	149	53	3	3a2f8c4173dcf9e3f8d3b8ffddbc597098adf7a9
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	FAM209A RTTN CCR6	7.68e-04	151	53	3	72c47ed207951e73ef6c72085b2a3f48a99be952
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FAM209A RTTN CCR6	7.82e-04	152	53	3	ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABHD17A PTPN4 FYN	7.97e-04	153	53	3	d8773ee16c7d3e0834b9f64054d42336d6f9833b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARSJ LAMB1 AGBL3	7.97e-04	153	53	3	d6526d17826470534b766df144c74e73eb83fdad
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	LAMB1 ADAMTS5 DNAJC6	8.28e-04	155	53	3	e1a20e88b9c0eaf7ca7004acc0eda096d1588563
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LAMB1 FYN SMAD1	8.43e-04	156	53	3	8790b4b400695571fcf1ccb24c658b5e90854ff7
ToppCell	Bac-SEP-Lymphocyte-T_NK-CD4_CTL\|Bac-SEP / Disease, Lineage and Cell Type	PTPN4 GALNT12 DNAJC6	8.75e-04	158	53	3	4beed58bf58253253fc7e5009294b35e3bb8eae3
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	PTPRG NYNRIN LAMB1	8.91e-04	159	53	3	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 CCR6 USH1C	9.07e-04	160	53	3	1cb6f42b68c9e41e8edae0de8f0d8371c4620b04
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF3IP2 CHST10 OSBPL10	9.07e-04	160	53	3	55f599df6e3b7a5a505df4b094c834281311d94a
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPN4 PTPRG FYN	9.07e-04	160	53	3	8e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRG KCTD19 TECTB	9.07e-04	160	53	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	URO-Other-RBC\|URO / Disease, Lineage and Cell Type	UGDH CA1 PTK7	9.07e-04	160	53	3	558f3b0719e2461a69e1b93b08e21675e8d07a5a
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FAM209A RTTN CCR6	9.07e-04	160	53	3	19105debef96ea0c267d6a1d332303ec668ae47e
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF3IP2 CHST10 OSBPL10	9.07e-04	160	53	3	296e53e1e0786346d38db2d4188b9a1c0430627b
ToppCell	URO-Other\|URO / Disease, Lineage and Cell Type	UGDH CA1 PTK7	9.07e-04	160	53	3	b0923e6bacfaba8ca40aa5706bf270eea0938b0a
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRG KCTD19 TECTB	9.07e-04	160	53	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Liver-Liver_non-hepato/SCs\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 CCR6 USH1C	9.07e-04	160	53	3	ebefde92db400cbe68d9ce31545a0308e0afbde1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG OSBPL10 LAMB1	9.74e-04	164	53	3	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NYNRIN LAMB1 ADAMTS5	9.74e-04	164	53	3	a764b79a127c8f360af0b79a1da64658badf0dfa
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN4 ADAMTS5 SEZ6L	9.92e-04	165	53	3	1703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCell	droplet-Lung-LUNG-1m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABHD17A GALNT12 FYN	1.01e-03	166	53	3	6e6075d0c913e2516083f6dcab21d5878bcef7a4
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF144B LRRC43 SEZ6L	1.01e-03	166	53	3	da10d0be6b616199d49dd922591c2901f9681583
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABHD17A GALNT12 FYN	1.01e-03	166	53	3	4fbe44e0aea197893614cd55f83119aa0f73ee53
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPN4 MFHAS1 CCR6	1.03e-03	167	53	3	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CAD LAMB1 CCR6	1.04e-03	168	53	3	8459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	CHST10 PTPRG PTK7	1.04e-03	168	53	3	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L3-5_THEMIS_UBE2F\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ IL1RAPL2 ASIC5	1.04e-03	168	53	3	bfa1491e8d433933003778b274710d3a16d973cb
ToppCell	Control-Lymphocyte-T_NK-MAIT\|Control / Disease, Lineage and Cell Type	PTPN4 CCR6 FYN	1.06e-03	169	53	3	8c2aac193a9c500f01a99a2ee530839c851b6222
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRRC43 MGA FYN	1.06e-03	169	53	3	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ OSBPL10 PTK7	1.08e-03	170	53	3	84d49a1f2989d98bd0acf9ec2d59f1042fc0f55b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MFHAS1 CCR6 FYN	1.08e-03	170	53	3	adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRMT11 LRRC43 FYN	1.08e-03	170	53	3	65c7ed586e7615203a59999549892ed466a89502
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ IL1RAPL2 ASIC5	1.10e-03	171	53	3	f648789e6aefe508bb748401bf9b3cd830fb0ddf
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ IL1RAPL2 ASIC5	1.10e-03	171	53	3	6a489a75eeab2a2d48d604682e93599c20a945fe
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ OSBPL10 PTK7	1.12e-03	172	53	3	cecfe5cf20f317ea01b4604789e07a14481c4cd6
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-NK_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABHD17A CHST10 LRRC43	1.12e-03	172	53	3	f3c16a62eba1ed190318beee131c71c5150b266a
ToppCell	10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-NK_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARSJ CCR6 LRRC43	1.12e-03	172	53	3	a126dacd94939851de1403d30f0b63eaad48bfa1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG SGK1 FYN	1.14e-03	173	53	3	afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABHD17A PTPN4 FYN	1.16e-03	174	53	3	7ebf06076946729c1af25109df6066731097c3b1
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABHD17A PTPN4 FYN	1.16e-03	174	53	3	90961e8839514985712b8b986aec3391bb249ba7
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABHD17A PTPN4 FYN	1.16e-03	174	53	3	c4b0987d9394f977fe6bc6a4214a6d8d73d0abcc
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 GALNT12 CCR6	1.16e-03	174	53	3	aae7ab9df5a78716034ddfd5bd47adc69912d624
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 GALNT12 CCR6	1.16e-03	174	53	3	d9489c4196d103ead8cb6279492bbe563a222e45
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF144B KCTD19 SEZ6L	1.16e-03	174	53	3	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ OSBPL10 PTK7	1.16e-03	174	53	3	e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell	10x5'-Lung-Lymphocytic_Invariant-Inducer-like-MAIT\|Lung / Manually curated celltypes from each tissue	CCR6 USH1C FYN	1.17e-03	175	53	3	f6663e5a9c87e27f3459a6481768b03aff7d0855
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ IL1RAPL2 ASIC5	1.17e-03	175	53	3	06af6629766e2054e6995e8cdb3907658fec49d3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B OSBPL10 AGBL3	1.17e-03	175	53	3	284fdc7a9d303636a637041846850d19d114861a
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT\|lymph-node_spleen / Manually curated celltypes from each tissue	PRSS22 CCR6 FYN	1.19e-03	176	53	3	25c197d3b39deffa4801a1d12cdb54320cbae509
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT12 FYN PTK2	1.19e-03	176	53	3	d4075796c38b775fe721abb47426e662a0d415e3
ToppCell	facs-Heart-RV-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRG KCTD19 SGK1	1.19e-03	176	53	3	fb3d03f64592e1df1d9785d9f2e70938d7ff9ce8
Computational	Neighborhood of JAK1	ABHD17A PTPN4 FYN	1.23e-04	32	33	3	GNF2_JAK1
Computational	Neighborhood of PTPN4	ABHD17A PTPN4 FYN	4.68e-04	50	33	3	GNF2_PTPN4
Computational	Neighborhood of ITGAL	ABHD17A PTPN4 FYN	6.20e-04	55	33	3	GNF2_ITGAL
Disease	peripheral arterial disease, traffic air pollution measurement	C6orf118 PTPRG UGDH GOT1 NSMCE1	2.59e-05	194	53	5	EFO_0004265, EFO_0007908
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD5	2.44e-04	13	53	2	DOID:0050787 (implicated_via_orthology)
Disease	C-reactive protein measurement	RNF144B TRAF3IP2 CAD MFHAS1 NYNRIN TRMT11 LRRC43 DNAJC6 PTK7	2.70e-04	1206	53	9	EFO_0004458
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	FAM209A FAM209B	5.31e-04	19	53	2	EFO_0007044, EFO_0020106
Disease	aspartate aminotransferase to alanine aminotransferase ratio	NYNRIN TECTB LRRC43 GOT1	9.00e-04	239	53	4	EFO_0010934
Disease	Dupuytren Contracture	PTPN4 PTPRG PTK2	9.78e-04	108	53	3	EFO_0004229
Disease	interleukin 2 measurement	TRAF3IP2 FYN	2.48e-03	41	53	2	EFO_0008331
Disease	electrocardiography	RNF144B MFHAS1 SGK1 FYN PTK2	2.59e-03	530	53	5	EFO_0004327
Disease	interleukin 9 measurement	RTTN SMAD5	2.73e-03	43	53	2	EFO_0008192
Disease	hepatocellular carcinoma (implicated_via_orthology)	CAD PTK2	3.53e-03	49	53	2	DOID:684 (implicated_via_orthology)
Disease	Heschl's gyrus morphology measurement	FAM209A FAM209B	4.11e-03	53	53	2	EFO_0005852
Disease	Metastatic melanoma	FYN PTK2	4.27e-03	54	53	2	C0278883

Protein segments in the cluster

Peptide	Gene	Start	Entry
DYVLEVRHFQCPKWP	PTPRG	1306	P23470
DWIDLVVAVCPPKEY	USH1C	531	Q9Y6N9
EMPADPYHVTICEIW	FAM209A	151	Q5JX71
PTRWPYHCEVIDEKV	AGBL3	86	Q8NEM8
QHIDWTPSCPEPVYI	AGBL3	101	Q8NEM8
LPLEEVWGPENYKHC	CATSPERE	821	Q5SY80
EWVPKYAGVLPADVC	ADAMTS5	651	Q9UNA0
VCEPKYQTVSEPIRW	CCR6	196	P51684
LYERCPKAVEPLWVE	ABHD17A	266	Q96GS6
QKEWVHVAPLPDTYR	PHYKPL	161	Q8IUZ5
VERGRVKCHQYWPEP	PTPN4	756	P29074
WPLFCQEVEEYHIPS	KCTD19	466	Q17RG1
EVHLDPYRTWCPVAD	RNF144B	111	Q7Z419
CETEPEQPVRHYPLW	MGA	1146	Q8IWI9
PCYVQNEVPHAEAWI	MFHAS1	851	Q9Y4C4
CKELVHITDWYPTLI	ARSJ	371	Q5FYB0
VEPHPVYSWKEGACA	PRSS22	126	Q9GZN4
EMPADPYHVTICKIW	FAM209B	151	Q5JX69
YEPQLPDHWEKAVIT	LAMB1	616	P07942
CHIYTFIEIPVCEPW	RFPL4A	236	A6NLU0
HPPLYESVTWIICKE	CA1	201	P00915
HCWKKDPEERPTFEY	FYN	501	P06241
VIDLTPPWEHYCTKD	DNAJC6	371	O75061
EPELYLKWKHCETPG	C6orf118	6	Q5T5N4
KWFLETVYPELHVPE	GALNT12	426	Q8IXK2
YRTDDCHPWVLPVVK	GOT1	41	P17174
VKTVHQEYPWGECNP	ASIC5	286	Q9NY37
CNDYWPHEIPKVFDP	NSMCE1	231	Q8WV22
TAHKPWAEVIPCSYE	LRRC43	456	Q8N309
CVPVPGESTWVKEAY	MCMBP	131	Q9BTE3
ELWKEVRYPPILHCA	NYNRIN	76	Q9P2P1
HWPPEKRVAYCFEVA	POFUT1	116	Q9H488
LVEKFVEPCRSDHWP	FIBP	306	O43427
IIKDYTWQGPCVHDE	RTTN	1451	Q86VV8
YTEEMVPWHPCLELV	TRMT11	381	Q7Z4G4
PRAAKVYWTCPAEDV	TRIM42	616	Q8IWZ5
EPYVEGEDCIWKIHV	SEZ6L	646	Q9BYH1
SDQEPDVVWYKECKP	IL1RAPL2	171	Q9NP60
SVREKYELAHPPEEW	PTK2	106	Q05397
PEVLHKQPYDRTVDW	SGK1	266	O00141
TIITKIPECPYGWEV	TECTB	36	Q96PL2
IPECPYGWEVHQLAL	TECTB	41	Q96PL2
PIIGETFHCSWEVPK	OSBPL10	481	Q9BXB5
QPVAYEEPKHWCSIV	SMAD5	261	Q99717
QAVAYEEPKHWCSIV	SMAD1	261	Q15797
PDIVLWPTCHDDVVK	AGPS	206	O00116
WYVPPEQAKVVASVH	AGFG1	126	P52594
KVILNYPSPWDHEER	TRAF3IP2	321	O43734
IHWVTYVELCAPCEI	CHST10	261	O43529
WYHTPNVVFIKTEDP	PRPF8	331	Q6P2Q9
CAVYEHWVPREKILT	UGDH	196	O60701
PSVDYCVVKIPRWDL	CAD	731	P27708
LFNPWCPEDIVYVDH	TGM1	246	P22735
YKCLAPEEVAEWLHL	TIGD5	521	Q53EQ6
LRCEVEAPGPVHVYW	PTK7	51	Q13308