Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontachykinin receptor activity

TACR2 TACR3

7.94e-063332GO:0004995
GeneOntologyMolecularFunctioncalcium-dependent cysteine-type endopeptidase activity

CAPN8 CAPN2

3.55e-0417332GO:0004198
GeneOntologyMolecularFunctionRNA cap binding

SNUPN CYFIP2

5.45e-0421332GO:0000339
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

TLR10 ENGASE SI

1.71e-03144333GO:0016798
GeneOntologyMolecularFunctionneuropeptide receptor activity

TACR2 TACR3

3.46e-0353332GO:0008188
DomainNeurokn_rcpt

TACR2 TACR3

9.64e-063342IPR001681
DomainCalpain_III

CAPN8 CAPN2

2.10e-0412342IPR022683
Domaincalpain_III

CAPN8 CAPN2

2.10e-0412342SM00720
DomainC2_III

CAPN8 CAPN2

2.10e-0412342IPR033883
DomainCalpain_domain_III

CAPN8 CAPN2

2.48e-0413342IPR022682
DomainCalpain_III

CAPN8 CAPN2

2.48e-0413342PF01067
DomainCalpain_cysteine_protease

CAPN8 CAPN2

2.89e-0414342IPR022684
DomainCysPc

CAPN8 CAPN2

3.33e-0415342SM00230
DomainCALPAIN_CAT

CAPN8 CAPN2

3.33e-0415342PS50203
DomainPeptidase_C2_calpain_cat

CAPN8 CAPN2

3.33e-0415342IPR001300
DomainPeptidase_C2

CAPN8 CAPN2

3.33e-0415342PF00648
DomainTHIOL_PROTEASE_CYS

CAPN8 CAPN2

1.02e-0326342PS00139
DomainTHIOL_PROTEASE_ASN

CAPN8 CAPN2

1.10e-0327342PS00640
DomainTHIOL_PROTEASE_HIS

CAPN8 CAPN2

1.10e-0327342PS00639
DomainPept_cys_AS

CAPN8 CAPN2

1.18e-0328342IPR000169
DomainL_dom-like

TLR10 LRRC63 INSR DMAC2

2.86e-03328344IPR032675
DomainGlycoside_hydrolase_SF

SI SLC3A1

4.18e-0353342IPR017853
DomainGPCR_2-like

ADGRL1 SMO

5.33e-0360342IPR017981
DomainGPCR_2_secretin-like

ADGRL1 SMO

5.33e-0360342IPR000832
DomainG_PROTEIN_RECEP_F2_4

ADGRL1 SMO

5.50e-0361342PS50261
PathwayREACTOME_TACHYKININ_RECEPTORS_BIND_TACHYKININS

TACR2 TACR3

2.77e-055242M27277
PathwayREACTOME_TACHYKININ_RECEPTORS_BIND_TACHYKININS

TACR2 TACR3

2.77e-055242MM14977
Pubmed

The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations.

CAPN8 CAPN2

9.84e-07235228002826
Pubmed

Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.

TACR2 TACR3

2.95e-06335218203813
Pubmed

Molecular cloning of the murine substance K and substance P receptor genes.

TACR2 TACR3

2.95e-0633521370937
Pubmed

Expression of the tachykinin receptor mRNAs in healthy human colon.

TACR2 TACR3

2.95e-06335218835556
Pubmed

Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.

CAPN8 CAPN2

9.82e-06535217646163
Pubmed

Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.

TACR2 TACR3

9.82e-06535211786503
Pubmed

Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis.

TACR2 TACR3

9.82e-06535210189055
Pubmed

Characterization of the endokinins: human tachykinins with cardiovascular activity.

TACR2 TACR3

1.47e-05635212716968
Pubmed

A role for tachykinins in the regulation of human sperm motility.

TACR2 TACR3

1.47e-05635217437961
Pubmed

A role for tachykinins in female mouse and rat reproductive function.

TACR2 TACR3

1.47e-05635212773411
Pubmed

Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation.

TACR2 TACR3

2.74e-05835217448763
Pubmed

A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).

TACR2 TACR3

2.04e-042135215452121
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

KCNK9 SLC3A1

2.68e-042435222534482
Pubmed

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.

TACR2 TACR3

8.66e-044335223597562
Pubmed

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

TLR10 TTC6

9.06e-044435223817569
InteractionTAC4 interactions

TACR2 TACR3

1.65e-054342int:TAC4
CytobandEnsembl 112 genes in cytogenetic band chr1q41

CAPN8 CAPN2

2.31e-0393352chr1q41
Cytoband17q25.3

AFMID ENGASE

2.72e-0310135217q25.3
GeneFamilyTachykinin receptors

TACR2 TACR3

4.64e-063232258
GeneFamilyC2 domain containing|Calpains

CAPN8 CAPN2

1.61e-0415232975
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

ZC3H7A TTC6

9.30e-03115232769
ToppCellBasal_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

SMO FHL2 TTC6 CH25H

6.04e-0615235472499e4d2b374ef5f1621c89d94727ecf4bd4d5d
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CAPN8 MCTP2 FRMD5 TTC6

1.08e-051763543bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellAdult-Epithelial-club_cell-D175|Adult / Lineage, Cell type, age group and donor

CAPN8 FRMD5 TTC6 INSR

1.10e-05177354d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CAPN8 SMO FHL2 CH25H

1.26e-05183354ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCellIPF-Epithelial-Goblet|Epithelial / Disease state, Lineage and Cell class

CAPN8 KIF13B FHL2 INSR

1.49e-05191354267e1192aaec468c1a59eb24848b37e0e18cbc44
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MFAP4 SMO FHL2 MCTP2

1.75e-051993546b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial-Proteoglycan-expressing_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

MFAP4 TNFAIP6 FHL2 CH25H

1.78e-05200354eed2bafddcd041ef5fcc4d1d31edb8be4d83ce01
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial|2m / Sample Type, Dataset, Time_group, and Cell type.

MFAP4 TNFAIP6 FHL2 CH25H

1.78e-052003543da9441c0f1e242f0d195de47ecd4c24dfdca232
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Calb2_(MGE-derived_cortical_interneurons--Martinotti_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TACR3 FOXR2 TTC6

2.58e-05733538e8d06bd4404fe6fda753e7adedc2f2150524750
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Calb2_(MGE-derived_cortical_interneurons--Martinotti_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TACR3 FOXR2 TTC6

2.58e-057335348a499fa03d736310d09b01c8889db5288e9b2da
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CAPN8 SI TNFAIP6

1.08e-041183536053e19d040fb394f9c270361af07b0c5a4d47db
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CAPN8 SI TNFAIP6

1.08e-04118353811e8521129914eef46785a4227c1860e77d9096
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Vipr2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MCTP2 TMEM229B CH25H

1.11e-041193536425425b2e622c97b6c74c530ccbfe394d3b202d
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_B1-4|TCGA-Thymus / Sample_Type by Project: Shred V9

LRRC63 HINFP TRAV2

1.79e-0414035321e5f55a98b819d3638ec971d5029b2fcbd1ebc7
ToppCellfacs-Marrow-B-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TACR3 MCTP2 TMEM229B

2.07e-041473539d7e965fe61bd7b31e09c4b2129a5a98c36f4811
ToppCellfacs-Marrow-B-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TACR3 MCTP2 TMEM229B

2.07e-0414735338552953ff65a0fc20bee6ef57dc5885306ad18b
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CAPN8 FRMD5 TTC6

2.11e-041483539fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCellAdult-Epithelial-basal_cell-D122|Adult / Lineage, Cell type, age group and donor

SMO FHL2 TTC6

2.38e-0415435338d346402417960044ae999e61f0092b46f2b591
ToppCell390C-Lymphocytic-Plasma_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

TLR10 KCNK9 TPTE2

2.47e-041563530de2fc695bd5f8d4633c514f71ea941c88137bac
ToppCell390C-Lymphocytic-Plasma_cell-|390C / Donor, Lineage, Cell class and subclass (all cells)

TLR10 KCNK9 TPTE2

2.47e-041563534f92ca30755430db44402afc603d1ecd8bfc3617
ToppCellBasal_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

SMO FHL2 FRMD5

2.56e-0415835351e3ed1b91b010404d66e3e7efdbffc0c815e25b
ToppCellBasal_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

SMO FHL2 CH25H

2.66e-04160353b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN8 TTC6 INSR

2.71e-041613532d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellControl-Lymphocytic_B|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR10 OTOS CYFIP2

3.01e-04167353956da82394fd6a9f45fc2031796f12cc889542cd
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CAPN8 ENGASE MCTP2

3.01e-04167353720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCellControl-Lymphocytic_B-B_cells-B-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR10 OTOS CYFIP2

3.01e-0416735369ed8a4a507190a1a66c4baf1f3e9be21ada39d8
ToppCellControl-Lymphocytic_B-B_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR10 OTOS CYFIP2

3.01e-04167353a15a70d3837b31cc83a2a9e3f1bbfd77a95f2312
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cells|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP2 CYFIP2 TMEM229B

3.07e-04168353e8878ec68b21c8d5694d7209b816d2f869673164
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP2 CYFIP2 TMEM229B

3.07e-04168353a007758c219d3d5db2b5529f29af63be0d408304
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CAPN8 SLC3A1 INSR

3.12e-0416935340b557549fe08c5dc9dba359af35993d68d1640a
ToppCellLPS-IL1RA-Lymphocytic_B|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR10 OTOS CYFIP2

3.17e-0417035356284fbfd1e53f67c8c0b7fba64505a4002adba2
ToppCellASK428-Epithelial-Secretory|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

CAPN8 FHL2 CH25H

3.17e-041703539e275c4a70f9866f770fbdb0fe14a577287fe290
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN8 LARP4B TTC6

3.17e-04170353a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR10 OTOS CYFIP2

3.17e-0417035392e0873f618b2fa60c4d555b10f234d5cbcf3325
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR10 OTOS CYFIP2

3.17e-04170353c181991f933b779f99afc3782f292306f209e2ac
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-mLTo|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MFAP4 SMO FHL2

3.17e-041703537653f1205d4e62abe7e31b1d76f9bbd665e45667
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN8 TTC6 INSR

3.34e-04173353464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCellAdult-Epithelial-basal_cell-D231|Adult / Lineage, Cell type, age group and donor

FHL2 FRMD5 TTC6

3.40e-04174353a4f98afe7d1cc2617f6f7bc8092c41df57474b30
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|356C / Donor, Lineage, Cell class and subclass (all cells)

SMO TTC6 INSR

3.45e-041753534bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

LRRC63 ADGRL1 MCTP2

3.45e-04175353c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|356C / Donor, Lineage, Cell class and subclass (all cells)

SMO TTC6 INSR

3.45e-04175353af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CAPN8 TTC6 INSR

3.57e-04177353779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CAPN8 TTC6 INSR

3.57e-041773530f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TLR10 ADGRL1 SMO

3.57e-04177353e68ad19963a3d8917dfdb81127a41c4fcbe61dd5
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIF13B FRMD5 CYFIP2

3.57e-0417735359726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN8 KIF13B TTC6

3.63e-04178353f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN8 KIF13B FHL2

3.75e-0418035335c73670da90cb6924e822a2426d13a675685f09
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MFAP4 TACR2 FHL2

3.81e-04181353ab0f300d14b62cef57f1b0bdae143b8dfe8e6975
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

CAPN8 FHL2 TTC6

3.81e-041813536d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MFAP4 TACR2 FHL2

3.87e-04182353728a2152c166551ac229370c0900fe2bc426ea9b
ToppCellPCW_05-06-Neuronal-Neuronal_SCP|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIF13B FRMD5 CYFIP2

3.87e-04182353b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN8 TTC6 INSR

3.87e-041823533f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 MCTP2 FRMD5

3.94e-041833537eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

CAPN8 FHL2 FRMD5

3.94e-0418335315d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

CAPN8 TTC6 INSR

3.94e-04183353940cbe298e9c53b5622af09264586ed823d3141f
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic-DC1|GI_small-bowel / Manually curated celltypes from each tissue

TLR10 CAPN8 SMO

4.00e-041843538e393eea7240584a3cef718bee094e2705ec1891
ToppCellFetal_29-31_weeks-Immune-B_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TLR10 MCTP2 CYFIP2

4.00e-04184353f4c9272d5cc4a70df051413b5c60ca6d1d80eb84
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFMID SLC3A1 INSR

4.00e-041843539434731f651820b05335085582960f08fbf895de
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

CAPN8 FHL2 FRMD5

4.00e-04184353d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF13B SI TTC6

4.06e-04185353d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 MCTP2 FRMD5

4.06e-041853533b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIF13B FRMD5 CYFIP2

4.06e-04185353a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

CAPN8 FRMD5 TTC6

4.06e-04185353cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCelldroplet-Marrow-nan-18m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRL1 SMO OTOS

4.06e-04185353de353368f4f6a7a0a66e391d586879876fbe2734
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN8 FRMD5 TTC6

4.13e-0418635302fbb02c495e7d64c4ab50e42e5197782f2c0816
ToppCellInfluenza-Influenza_Severe-Myeloid-Neutrophil|Influenza_Severe / Disease, condition lineage and cell class

TNFAIP6 MCTP2 SLC3A1

4.13e-041863531dfcec9196d4db76fba3abc74e85885b1fb98b87
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CAPN8 MCTP2 FRMD5

4.13e-04186353acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 TNFAIP6 FRMD5

4.13e-04186353827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCellCF|World / Disease state, Lineage and Cell class

TNFAIP6 MCTP2 CYFIP2

4.19e-04187353eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

CAPN8 TTC6 INSR

4.19e-04187353ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellPCW_05-06-Neuronal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIF13B FRMD5 CYFIP2

4.19e-0418735303a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCellImmune-B_cell|World / Lineage, Cell type, age group and donor

TLR10 MCTP2 CYFIP2

4.19e-04187353795690c6306c366e733279491138d0cd9b469b21
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

KIF13B MFAP4 CH25H

4.26e-04188353c90669b51e1902fe7726555290c91c92a911df83
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CAPN8 FRMD5 CAPN2

4.26e-0418835343a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHL2 FRMD5 CYFIP2

4.26e-04188353ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHL2 FRMD5 CYFIP2

4.26e-041883534db566f3f708e66730aa9e16f4d73d91dc534177
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHL2 FRMD5 CYFIP2

4.26e-041883536704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHL2 FRMD5 CYFIP2

4.26e-0418835340ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

CAPN8 FRMD5 TTC6

4.26e-04188353c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP6 FHL2 FRMD5

4.33e-04189353a5306561026e4dfcc39beeb785e5108ac595d136
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

CAPN8 TTC6 INSR

4.33e-0418935384d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 TNFAIP6 CH25H

4.33e-04189353562f8bf5a7d38afb4a8f2415d617d5f79cfb7e3f
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP6 FHL2 FRMD5

4.33e-04189353302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCellfacs-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP6 FHL2 FRMD5

4.33e-04189353381058f55908f84375b54601d617389ef43ab855
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 TNFAIP6 CH25H

4.33e-04189353270dd4a0fc5260288fe6829837942c78b40ecec4
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

CAPN8 TTC6 INSR

4.39e-04190353756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CAPN8 FRMD5 TTC6

4.39e-0419035327a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN8 AFMID KIF13B

4.46e-041913533e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCellfacs-Heart-LV-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHL2 FRMD5 CYFIP2

4.46e-041913539d7d680da3979e256191b534ebd14c5383e0cf93
ToppCellfacs-Heart-LV-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHL2 FRMD5 CYFIP2

4.46e-04191353543da1197c7e62f2c9cbd4a51414bbaaa6d1a92f
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TACR3 FRMD5 TTC6

4.46e-0419135339220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCellFetal_29-31_weeks-Immune-B_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TLR10 MCTP2 CYFIP2

4.46e-0419135384452125d1b5b76974e3f9126f611eff16d45c25
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCTP2 CYFIP2 TMEM229B

4.46e-041913536345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

CAPN8 FRMD5 TTC6

4.46e-04191353276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MFAP4 TNFAIP6 FHL2

4.53e-0419235341a8326cd5bc19ad5041068501bab4c72399222e
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MCTP2 TTC6 CYFIP2

4.53e-04192353b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MFAP4 TNFAIP6 FHL2

4.53e-04192353f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MFAP4 TACR2 FHL2

4.60e-04193353a402e736440684ebe123673b6b0c6fcd8fa057b2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MFAP4 TNFAIP6 FHL2

4.60e-04193353dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellControl-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

MCTP2 CYFIP2 INSR

4.60e-041933533479c01aaae7afd7e02d00e0cb21951c0106a0fd
Drug(N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide)

TACR2 TACR3

6.49e-063342ctd:C502587
DrugNifuroxazide [965-52-6]; Down 200; 14.6uM; HL60; HT_HG-U133A

KIF13B ADGRL1 LARP4B MCTP2 SLC3A1

8.34e-061883452490_DN
DrugMen10354

TACR2 TACR3

1.30e-054342CID003083370
DrugAC1L51LV

TACR2 TACR3

2.16e-055342CID000196380
DrugAC1L53LJ

SI SLC3A1

2.16e-055342CID000197521
Drug2-(4-nitrophenyl)benzoxazole

TACR2 TACR3

2.16e-055342CID000070047
DrugSpm-SP

TACR2 TACR3

3.23e-056342CID003081857
DrugL-659,837

TACR2 TACR3

4.52e-057342CID006444163
Drugdiphenylpropionic acid

TACR2 TACR3

4.52e-057342CID000064798
DrugMen 10456

TACR2 TACR3

4.52e-057342CID000189859
DrugAC1O44I5

TACR2 TACR3

4.52e-057342CID006324620
DrugGR159897

TACR2 TACR3

4.52e-057342CID003570748
Drugisomaltotetraose

SI SLC3A1

4.52e-057342CID003080783
DrugNeurokinin A-oh

TACR2 TACR3

4.52e-057342CID000147040
DrugLY303870

TACR2 TACR3

4.52e-057342CID003086681
DrugLom-TK-I

TACR2 TACR3

6.03e-058342CID000195503
DrugAC1L4Z4R

TACR2 TACR3

6.03e-058342CID000194918
DrugBhsar-SP

TACR2 TACR3

6.03e-058342CID000163829
Druginaperisone

TACR2 TACR3

7.74e-059342CID000065860
DrugSp(7-11)

TACR2 TACR3

7.74e-059342CID003084967
Drugphyllomedusin

TACR2 TACR3

7.74e-059342CID000168489
DrugAC1MIXOF

TACR2 TACR3

7.74e-059342CID003081850
DrugR396

TACR2 TACR3

9.67e-0510342CID000164286
DrugAC1L2Y4S

TACR2 TACR3

9.67e-0510342CID000130848
DrugUperolein

TACR2 TACR3

9.67e-0510342CID003085088
DrugR 487

TACR2 TACR3

9.67e-0510342CID000131469
DrugNka-(4-10)

TACR2 TACR3

1.18e-0411342CID000122230
DrugFG5P

SI SLC3A1

1.18e-0411342CID000127486
DrugCp96

TACR2 TACR3

1.18e-0411342CID000086380
Drugezlopitant

TACR2 TACR3

1.18e-0411342CID000188927
DrugAC1Q5XN5

TACR2 TACR3

1.18e-0411342CID000190946
DrugMdl 28,564

TACR2 TACR3

1.18e-0411342CID003081745
DrugMdl 29913

TACR2 TACR3

1.42e-0412342CID003081272
DrugPD140548

TACR2 TACR3

1.67e-0413342CID005311347
Drug2-phenylquinoline

TACR2 TACR3

1.67e-0413342CID000071545
DrugScyliorhinin I

TACR2 TACR3

1.67e-0413342CID000147048
DrugGr 73632

TACR2 TACR3

1.95e-0414342CID000119599
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; PC3; HG-U133A

HINFP KIF13B SMO CYFIP2

2.02e-041963441923_UP
DrugNafronyl oxalate [3200-06-4]; Down 200; 8.4uM; MCF7; HT_HG-U133A

ENGASE ADGRL1 SNUPN CYFIP2

2.06e-041973445287_DN
DrugAlthiazide [5588-16-9]; Down 200; 10.4uM; MCF7; HT_HG-U133A

ENGASE KIF13B ADGRL1 INSR

2.10e-041983446089_DN
DrugBupropion hydrochloride [31677-93-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A

HINFP ADGRL1 CYFIP2 INSR

2.10e-041983446256_DN
DrugMetampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

ENGASE ADGRL1 CAPN2 INSR

2.10e-041983442123_DN
DrugNitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A

ENGASE ADGRL1 SNUPN CYFIP2

2.14e-041993445321_DN
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A

ENGASE KIF13B ADGRL1 INSR

2.18e-042003442838_DN
DrugGr-94800

TACR2 TACR3

2.56e-0416342CID005487475
DrugMen 10627

TACR2 TACR3

2.56e-0416342CID006438356
DrugFk 224

TACR2 TACR3

2.56e-0416342CID006437864
Drugcapsazepine

TACR2 TACR3 KCNK9

2.67e-0484343CID002733484
DrugL-703, 606 oxalate

TACR2 TACR3

2.90e-0417342CID000003851
Drugalaninamide

TACR2 TACR3

2.90e-0417342CID000350287
DrugL-732,138

TACR2 TACR3

2.90e-0417342CID000132837
DrugMEN 11420

TACR2 TACR3

2.90e-0417342CID003086682
DrugDimethyl C7

TACR2 TACR3

3.26e-0418342CID000123994
Drugindolizine

AFMID TACR2

3.26e-0418342CID000009230
DrugGR 64349

TACR2 TACR3

3.64e-0419342CID003036081
DrugAC1L1GT5

KIF13B ADGRL1 SMO

3.83e-0495343CID000003829
DrugSendide

TACR2 TACR3

4.04e-0420342CID000122140
Drugglycitein

TACR3 TNFAIP6 FHL2

4.20e-0498343ctd:C086566
DrugL-670,596

AFMID TACR2

4.47e-0421342CID000129360
DrugI0329

SI SLC3A1

4.47e-0421342CID000439668
Drug1-deoxynojirimycin hydrochloride

ADGRL1 SI SLC3A1

4.72e-04102343CID000001374
DrugSp(1-7)

TACR2 TACR3

4.91e-0422342CID000115322
Drugemiglitate

ENGASE SI

4.91e-0422342CID000072004
Drugbeta-alanine

TACR2 TACR3 SLC3A1

5.00e-04104343CID000000239
DrugSubstance P Octapeptide

TACR2 TACR3

5.37e-0423342CID000171298
DrugPalatinose hydrate

SI SLC3A1

5.37e-0423342CID000093971
Drugaganodine

TACR2 TACR3

5.37e-0423342CID000176878
Drugginsenoside

SI SLC3A1

5.37e-0423342CID000092797
Diseasehereditary spastic paraplegia 76 (implicated_via_orthology)

CAPN8 CAPN2

1.36e-055352DOID:0110821 (implicated_via_orthology)
Diseasepre-malignant neoplasm (biomarker_via_orthology)

SMO INSR

1.84e-0417352DOID:0060071 (biomarker_via_orthology)
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CAPN8 CAPN2

8.40e-0436352DOID:11723 (implicated_via_orthology)
Diseasecolitis (biomarker_via_orthology)

SI TACR2

1.14e-0342352DOID:0060180 (biomarker_via_orthology)
Diseasehereditary spastic paraplegia (implicated_via_orthology)

CAPN8 CAPN2

1.20e-0343352DOID:2476 (implicated_via_orthology)
Diseaseretinal drusen

CAPN8 ENGASE

1.68e-0351352EFO_1001155
Diseaseintellectual disability (implicated_via_orthology)

CAPN8 CAPN2

3.59e-0375352DOID:1059 (implicated_via_orthology)
Diseasevisual epilepsy (biomarker_via_orthology)

SMO TACR3

5.13e-0390352DOID:11832 (biomarker_via_orthology)
Diseasephosphatidylinositol measurement

TTC6 TMEM229B

5.70e-0395352EFO_0010230

Protein segments in the cluster

PeptideGeneStartEntry
NQAWHLFAHECPNYF

AKR7L

316

Q8NHP1
NHFNANCSFWNYSER

ADGRL1

796

O94910
FQENYAGIFHFQFWQ

CAPN8

131

A6NHC0
YGHFSQEFWNFCEVP

DMAC2

111

Q9NW81
FDSPEFHRQSWEFYQ

AFMID

246

Q63HM1
AAFSQCEEWSFFHAY

KCNK9

176

Q9NPC2
ANPQWQEQFDFHYFS

MCTP2

396

Q6DN12
NCEFAYNDNWFITFE

LARP4B

266

Q92615
FENNFTHPCFWRDNY

LRRC63

466

Q05C16
PYYHFQDWRCVNFSF

INSR

271

P06213
HVFWELNFDFLPNYC

CYFIP2

866

Q96F07
PFSTSDFWNYVQHFQ

OTOS

41

Q8NHW6
FEQFHYQYFCPLRRW

FRMD5

541

Q7Z6J6
FQIPWFHDRFCQQYN

FASTKD1

676

Q53R41
YISFEERQWHNDCFN

FHL2

236

Q14192
QEIYNFTRQHFPFFW

FOXR2

216

Q6PJQ5
SCDGFFTNYNWREEH

ENGASE

296

Q8NFI3
CENSFDNPEWFYRHV

HINFP

136

Q9BQA5
FQENYAGIFHFQFWQ

CAPN2

131

P17655
FNCNFAPYFTHWDKI

CH25H

246

O95992
HNIWYFGRAFCYFQN

TACR2

96

P21452
HFVFCKYSFWDQQEP

KIF13B

886

Q9NQT8
LSPNFVQNEWCHYEF

TLR10

696

Q9BXR5
RQFNACPWDYSQFDF

TMEM229B

96

Q8NBD8
AFWFRSCHFANLNGF

MFAP4

206

P55083
NSSWHFDEVRNQCYF

SLC3A1

261

Q07837
WNQIFSENERFNCYP

SI

931

P14410
WRGHPFYDCQTDFRF

SNUPN

191

O95149
WYFGANYCRFQNFFP

TACR3

151

P29371
FPNEYEDNQICYWHI

TNFAIP6

151

P98066
CPFWAAVYFNRAHFY

TTC6

446

Q86TZ1
TFSCHFYDFFNQAEW

SMO

466

Q99835
FHTEDDQYCWQHRFP

ZC3H7A

886

Q8IWR0
YDNCPFFFWFNTSFI

TPTE2

471

Q6XPS3
FCNHSVSNAYNFFWY

TRAV2

46

A0A0B4J234