Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEF POTEE POTEI	5.46e-05	11	141	3	GO:0098973
GeneOntologyMolecularFunction	neuregulin receptor activity	ERBB3 ERBB4	1.48e-04	3	141	2	GO:0038131
GeneOntologyMolecularFunction	1-phosphatidylinositol binding	ZFYVE16 MCF2L SCIN	2.18e-04	17	141	3	GO:0005545
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF13B MYO1E SMCHD1 DHX15 SLFN13 HELZ2 ABCC12 SLFN11 ATP2A3 DNAH8 SMC1B	3.02e-04	441	141	11	GO:0016887
Domain	ANK	POTEB3 POTEF POTED POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	2.71e-05	251	145	10	SM00248
Domain	ANK_REPEAT	POTEB3 POTEF POTED POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	2.90e-05	253	145	10	PS50088
Domain	ANK_REP_REGION	POTEB3 POTEF POTED POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	3.00e-05	254	145	10	PS50297
Domain	Ankyrin_rpt	POTEB3 POTEF POTED POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	3.90e-05	262	145	10	IPR002110
Domain	Ank_2	POTEB3 POTEF POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	4.71e-05	215	145	9	PF12796
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	5.99e-05	2	145	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	5.99e-05	2	145	2	PF09268
Domain	-	CLTCL1 CLTC	5.99e-05	2	145	2	2.130.10.110
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	5.99e-05	2	145	2	IPR016341
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	5.99e-05	2	145	2	IPR001473
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	5.99e-05	2	145	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	5.99e-05	2	145	2	PF01394
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	5.99e-05	2	145	2	IPR015348
Domain	DUF1220	NBPF11 NBPF9 NBPF14	7.23e-05	11	145	3	PF06758
Domain	NBPF_dom	NBPF11 NBPF9 NBPF14	7.23e-05	11	145	3	IPR010630
Domain	NBPF	NBPF11 NBPF9 NBPF14	7.23e-05	11	145	3	PS51316
Domain	Ank	POTEF POTED POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	7.41e-05	228	145	9	PF00023
Domain	-	POTEB3 POTEF POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	1.40e-04	248	145	9	1.25.40.20
Domain	Ankyrin_rpt-contain_dom	POTEB3 POTEF POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	1.68e-04	254	145	9	IPR020683
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	1.79e-04	3	145	2	IPR012331
Domain	DUF2075	SLFN13 SLFN11	1.79e-04	3	145	2	PF09848
Domain	DUF2075	SLFN13 SLFN11	1.79e-04	3	145	2	IPR018647
Domain	CLH	CLTCL1 CLTC	1.79e-04	3	145	2	SM00299
Domain	Actin_CS	POTEF POTEE POTEI	2.38e-04	16	145	3	IPR004001
Domain	L_dom-like	ERBB3 ERBB4 LRCH2 TMOD4 LRCH1 LRRC14B LRGUK CMIP TMOD1 DRC3	2.47e-04	328	145	10	IPR032675
Domain	ACTINS_2	POTEF POTEE POTEI	2.88e-04	17	145	3	PS00432
Domain	Furin_repeat	ERBB3 ERBB4 RSPO3	3.43e-04	18	145	3	IPR006212
Domain	Actin/actin-like_CS	POTEF POTEE POTEI	3.43e-04	18	145	3	IPR020902
Domain	FU	ERBB3 ERBB4 RSPO3	3.43e-04	18	145	3	SM00261
Domain	Tyr_kinase_EGF/ERB/XmrK_rcpt	ERBB3 ERBB4	3.56e-04	4	145	2	IPR016245
Domain	ACTINS_ACT_LIKE	POTEF POTEE POTEI	4.05e-04	19	145	3	PS01132
Domain	Pkinase_Tyr	ERBB3 ERBB4 FLT4 JAK2 GUCY2F TESK2	5.13e-04	129	145	6	PF07714
Domain	U2AF_small	U2AF1L4 U2AF1	5.89e-04	5	145	2	IPR009145
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB3 ERBB4 FLT4 JAK2 GUCY2F TESK2	7.32e-04	138	145	6	IPR001245
Domain	SMC_hinge	SMCHD1 SMC1B	8.80e-04	6	145	2	SM00968
Domain	GF_recep_IV	ERBB3 ERBB4	8.80e-04	6	145	2	PF14843
Domain	GF_recep_IV	ERBB3 ERBB4	8.80e-04	6	145	2	IPR032778
Domain	SMC_hinge	SMCHD1 SMC1B	8.80e-04	6	145	2	PF06470
Domain	SMC_hinge	SMCHD1 SMC1B	8.80e-04	6	145	2	IPR010935
Domain	PROTEIN_KINASE_TYR	ERBB3 ERBB4 FLT4 JAK2 TESK2	9.56e-04	97	145	5	PS00109
Domain	Tyr_kinase_AS	ERBB3 ERBB4 FLT4 JAK2 TESK2	9.56e-04	97	145	5	IPR008266
Domain	Clathrin	CLTCL1 CLTC	1.23e-03	7	145	2	PF00637
Domain	TMOD	TMOD4 TMOD1	1.23e-03	7	145	2	IPR004934
Domain	AlbA_2	SLFN13 SLFN11	1.23e-03	7	145	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	1.23e-03	7	145	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	1.23e-03	7	145	2	IPR007421
Domain	Recep_L_domain	ERBB3 ERBB4	1.23e-03	7	145	2	PF01030
Domain	Tropomodulin	TMOD4 TMOD1	1.23e-03	7	145	2	PF03250
Domain	Furin-like	ERBB3 ERBB4	1.23e-03	7	145	2	PF00757
Domain	Rcpt_L-dom	ERBB3 ERBB4	1.23e-03	7	145	2	IPR000494
Domain	Furin-like_Cys-rich_dom	ERBB3 ERBB4	1.23e-03	7	145	2	IPR006211
Domain	CHCR	CLTCL1 CLTC	1.23e-03	7	145	2	PS50236
Domain	-	ERBB3 ERBB4	1.23e-03	7	145	2	3.80.20.20
Domain	ARM-type_fold	RAP1GDS1 CLTCL1 ATR UPF2 PKP3 CLTC IPO13 DIAPH3 PUM1	1.34e-03	339	145	9	IPR016024
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	1.63e-03	8	145	2	IPR000547
Domain	Actin	POTEF POTEE POTEI	1.76e-03	31	145	3	IPR004000
Domain	Actin	POTEF POTEE POTEI	1.76e-03	31	145	3	PF00022
Domain	ACTIN	POTEF POTEE POTEI	1.76e-03	31	145	3	SM00268
Domain	DUF1220	NBPF11 NBPF9	2.08e-03	9	145	2	SM01148
Domain	P-loop_NTPase	KIF13B RAB9B GBP6 MYO1E DHX15 LRGUK SLFN13 ERAL1 STARD9 UCKL1 HELZ2 ABCC12 SLFN11 DNAH8 SMC1B	2.49e-03	848	145	15	IPR027417
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF8 KLHL1 POTEF SMCHD1 NBPF11 DHX15 POTEE STARD9 NBPF9 TAF7L CLTC NBPF10 SPAG17 SCIN NBPF14 ATP2A3	8.90e-10	513	150	16	25798074
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF8 NBPF11 NBPF9 NBPF10 NBPF14	2.69e-08	21	150	5	16079250
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	POTED POTEE POTEM POTEI	4.12e-08	9	150	4	16364570
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEF POTEE POTEM POTEI	4.37e-07	15	150	4	16824795
Pubmed	Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.	INPP5B U2AF1L4 U2AF1 TAF7L DRC3	1.85e-06	47	150	5	29617656
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEB3 POTED POTEE	2.72e-06	7	150	3	15276201
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STARD13 KIF13B CLTCL1 POTEF SMCHD1 GATB PTPN21 PSMA8 RYR2 SPTBN4 POTEE STARD9 CLTC DIAPH3 POTEI MCF2L SPAG17 ATP2A3 DNAH8 PLXNA2	4.23e-06	1442	150	20	35575683
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEB3 POTED POTEC	4.33e-06	8	150	3	12475935
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	STARD13 POTEB3 POTEF POTEC POTEE POTEM POTEI	7.32e-06	163	150	7	24316575
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	PRPSAP1 OSTM1 HECTD3 SMCHD1 TATDN2 PPM1G U2AF1 PELO POLR1E ERAL1 CLTC GEMIN4 SLFN11	7.35e-06	670	150	13	22990118
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF9 NBPF14	9.23e-06	10	150	3	22973535
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF8 USP25 NBPF11 DHX15 NBPF9 NBPF10 NBPF14	9.64e-06	170	150	7	23314748
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KIF13B PPM1G POTEE PELO CLTC SLFN11 DIAPH3 CRYBG3 POTEI SCIN ANKRD52 NIN	1.01e-05	588	150	12	38580884
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CLSTN3 LRCH2 ZFYVE16 GON4L STARD9 CLTC MCF2L PUM1 RUBCN PLXNA2	1.18e-05	407	150	10	12693553
Pubmed	Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.	RYR2 RSPO3 TMOD1 PLXNA2	1.39e-05	34	150	4	31024170
Pubmed	Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.	ERBB3 ERBB4	1.85e-05	2	150	2	26745281
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEF POTEE	1.85e-05	2	150	2	19669888
Pubmed	SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.	SREBF2 SCAP	1.85e-05	2	150	2	27601673
Pubmed	ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.	ATR PLK1	1.85e-05	2	150	2	12147700
Pubmed	The discrete and combined effect of SREBP-2 and SCAP isoforms in the control of plasma lipids among familial hypercholesterolaemia patients.	SREBF2 SCAP	1.85e-05	2	150	2	16466730
Pubmed	The upgraded role of HER3 and HER4 receptors in breast cancer.	ERBB3 ERBB4	1.85e-05	2	150	2	19481955
Pubmed	Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients.	ERBB3 ERBB4	1.85e-05	2	150	2	26254096
Pubmed	SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction.	SREBF2 SCAP	1.85e-05	2	150	2	17383658
Pubmed	Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.	SREBF2 SCAP	1.85e-05	2	150	2	10896675
Pubmed	The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation.	U2AF1L4 U2AF1	1.85e-05	2	150	2	32116123
Pubmed	[Expression and significance of ErbB3 and ErbB4 in patients with laryngeal squamous cell carcinomas].	ERBB3 ERBB4	1.85e-05	2	150	2	17969526
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	1.85e-05	2	150	2	8733129
Pubmed	Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients.	ERBB3 ERBB4	1.85e-05	2	150	2	18182100
Pubmed	HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis.	ERBB3 ERBB4	1.85e-05	2	150	2	27536774
Pubmed	ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo.	RYR2 CD38	1.85e-05	2	150	2	17652368
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	1.85e-05	2	150	2	29097553
Pubmed	Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.	ATG2A CFAP298	1.85e-05	2	150	2	28410202
Pubmed	Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.	SREBF2 SCAP	1.85e-05	2	150	2	19116028
Pubmed	Sterol regulatory element-binding transcription factor (SREBF)-2, SREBF cleavage-activating protein (SCAP), and premature coronary artery disease in a Chinese population.	SREBF2 SCAP	1.85e-05	2	150	2	20111910
Pubmed	HER3 and HER4 are highly expressed in human meningiomas.	ERBB3 ERBB4	1.85e-05	2	150	2	31400925
Pubmed	Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).	SREBF2 SCAP	1.85e-05	2	150	2	24478315
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	1.85e-05	2	150	2	20065094
Pubmed	A unique insertion in STARD9's motor domain regulates its stability.	STARD9 PLK1	1.85e-05	2	150	2	25501367
Pubmed	JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein.	JAK2 NIN	1.85e-05	2	150	2	25332239
Pubmed	Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells.	SREBF2 SCAP	1.85e-05	2	150	2	23454642
Pubmed	4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation.	ERBB3 ERBB4	1.85e-05	2	150	2	28851073
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	1.85e-05	2	150	2	37833372
Pubmed	Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.	TMOD4 TMOD1	1.85e-05	2	150	2	26586224
Pubmed	Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers.	TMOD4 TMOD1	1.85e-05	2	150	2	24072783
Pubmed	ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery.	ERBB3 ERBB4	1.85e-05	2	150	2	19390858
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	1.85e-05	2	150	2	29563550
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	PPM1G DHX15 U2AF1 POLR1E PKP3 CLTC AHCY HELZ2 PLK1 HSD17B8	3.94e-05	469	150	10	37314180
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	5.53e-05	3	150	2	19509056
Pubmed	Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP.	SREBF2 SCAP	5.53e-05	3	150	2	32054686
Pubmed	Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development.	ERBB3 ERBB4	5.53e-05	3	150	2	12112465
Pubmed	The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments.	TMOD4 TMOD1	5.53e-05	3	150	2	11016930
Pubmed	ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury.	ERBB3 ERBB4	5.53e-05	3	150	2	30637799
Pubmed	erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation.	ERBB3 ERBB4	5.53e-05	3	150	2	9851845
Pubmed	Characterization of U2AF(6), a splicing factor related to U2AF(35).	U2AF1L4 U2AF1	5.53e-05	3	150	2	11739736
Pubmed	The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.	ERBB3 ERBB4	5.53e-05	3	150	2	28304405
Pubmed	A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.	INPP5B CLTC	5.53e-05	3	150	2	19536138
Pubmed	Expression and significance of HER family receptors in neuroblastic tumors.	ERBB3 ERBB4	5.53e-05	3	150	2	21203803
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	5.53e-05	3	150	2	38875319
Pubmed	High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.	ERBB3 ERBB4	5.53e-05	3	150	2	24901400
Pubmed	Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer.	ERBB3 JAK2	5.53e-05	3	150	2	20639901
Pubmed	Endofin recruits clathrin to early endosomes via TOM1.	ZFYVE16 CLTC	5.53e-05	3	150	2	15657082
Pubmed	Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4).	ERBB3 ERBB4	5.53e-05	3	150	2	28653892
Pubmed	PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling.	ERBB4 PTPN21	5.53e-05	3	150	2	25681686
Pubmed	The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.	SREBF2 SCAP	5.53e-05	3	150	2	31303399
Pubmed	Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.	SREBF2 SCAP	5.53e-05	3	150	2	14512514
Pubmed	An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels.	ERBB3 ERBB4	5.53e-05	3	150	2	11867753
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	5.53e-05	3	150	2	22891263
Pubmed	Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells.	ERBB3 ERBB4	5.53e-05	3	150	2	22891299
Pubmed	Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.	ERBB3 ERBB4	5.53e-05	3	150	2	7689552
Pubmed	ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma.	ERBB3 ERBB4	5.53e-05	3	150	2	23333248
Pubmed	Expression and potential role of ErbB receptors in type II endometrial cancer.	ERBB3 ERBB4	5.53e-05	3	150	2	23395558
Pubmed	Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation.	ERBB4 JAK2	5.53e-05	3	150	2	18653779
Pubmed	Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.	SREBF2 SCAP	5.53e-05	3	150	2	9242699
Pubmed	Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.	PLK1 NIN	5.53e-05	3	150	2	16254247
Pubmed	Evolution and expression of chimeric POTE-actin genes in the human genome.	POTEF POTEE	5.53e-05	3	150	2	17101985
Pubmed	Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.	ERBB3 ERBB4	5.53e-05	3	150	2	9516479
Pubmed	Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle.	TMOD4 TMOD1	5.53e-05	3	150	2	24430868
Pubmed	RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells.	ATR PLK1	5.53e-05	3	150	2	24142876
Pubmed	Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1.	ATR PLK1	5.53e-05	3	150	2	37773176
Pubmed	Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis.	ERBB3 ERBB4	5.53e-05	3	150	2	9565587
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	5.53e-05	3	150	2	15133132
Pubmed	Evaluation of type 1 growth factor receptor family expression in benign and malignant thyroid lesions.	ERBB3 ERBB4	5.53e-05	3	150	2	18424286
Pubmed	Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival.	ERBB3 ERBB4	5.53e-05	3	150	2	25731189
Pubmed	Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.	ERBB4 SREBF2	5.53e-05	3	150	2	26535009
Pubmed	Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.	SREBF2 SCAP	5.53e-05	3	150	2	23563690
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CLSTN3 HECTD3 SREBF2 EXT2 OSGEP PPM1G FZD6 SCAP PNPLA6 PELO CLTC GEMIN4 ANKRD17 PUM1	6.18e-05	942	150	14	31073040
Pubmed	GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.	STARD13 RYR2	1.10e-04	4	150	2	22328512
Pubmed	The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.	ERBB3 ERBB4	1.10e-04	4	150	2	16685269
Pubmed	Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.	ERBB3 ERBB4	1.10e-04	4	150	2	24557338
Pubmed	Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2.	JAK2 CLTC	1.10e-04	4	150	2	22935703
Pubmed	Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.	ERBB3 ERBB4	1.10e-04	4	150	2	23991224
Pubmed	Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.	ERBB3 ERBB4	1.10e-04	4	150	2	11425901
Pubmed	[Neuregulin-1 promotes proliferation and migration of human coronary artery smooth muscle cells by enhancing its receptor phosphorylation].	ERBB3 ERBB4	1.10e-04	4	150	2	26648299
Pubmed	Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.	SREBF2 SCAP	1.10e-04	4	150	2	19740467
Pubmed	Expression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers.	ERBB3 ERBB4	1.10e-04	4	150	2	19148499
Pubmed	Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.	ERBB3 ERBB4	1.10e-04	4	150	2	22327010
Pubmed	Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.	ERBB3 ERBB4	1.10e-04	4	150	2	17177598
Pubmed	LRCH proteins: a novel family of cytoskeletal regulators.	LRCH2 LRCH1	1.10e-04	4	150	2	20805893
Pubmed	HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.	ERBB3 ERBB4	1.10e-04	4	150	2	21203579
Pubmed	The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.	SREBF2 SCAP	1.10e-04	4	150	2	19706601
Interaction	POTED interactions	POTEB3 POTED POTEC	1.48e-06	4	146	3	int:POTED
Interaction	POTEC interactions	POTEB3 POTEF POTED POTEC	1.80e-06	13	146	4	int:POTEC
Interaction	NEK4 interactions	NBPF8 KLHL1 POTEF SMCHD1 NBPF11 DHX15 POTEE STARD9 NBPF9 TAF7L CLTC NBPF10 SPAG17 SCIN NBPF14 ATP2A3	5.16e-06	582	146	16	int:NEK4
Interaction	CDC25C interactions	STARD13 KIF13B ERBB3 ERBB4 CCNF PTPN13 TESK2 PLK1	1.84e-05	156	146	8	int:CDC25C
Cytoband	1q21.1	NBPF8 NBPF11 NBPF9 NBPF10 NBPF14	2.00e-06	62	151	5	1q21.1
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEF POTED POTEC POTEE POTEM POTEI	5.20e-11	13	104	6	685
GeneFamily	Neuroblastoma breakpoint family	NBPF8 NBPF26 NBPF11 NBPF9 NBPF10 NBPF14	2.92e-09	23	104	6	662
GeneFamily	Ankyrin repeat domain containing	POTEF POTED POTEC POTEE POTEM ANKRD17 POTEI ANKRD52 ANKRD16	1.08e-05	242	104	9	403
GeneFamily	Erb-b2 receptor tyrosine kinases	ERBB3 ERBB4	1.95e-04	4	104	2	1096
GeneFamily	Tropomodulins	TMOD4 TMOD1	1.95e-04	4	104	2	1140
GeneFamily	Schlafen family	SLFN13 SLFN11	6.75e-04	7	104	2	1110
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTPN21 JAK2 PTPN13	2.98e-03	50	104	3	1293
GeneFamily	StAR related lipid transfer domain containing	STARD13 STARD9	3.28e-03	15	104	2	759
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN21 PTPN13	4.72e-03	18	104	2	812
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NBPF8 KLHL1 BAZ2B RYR2 CMIP UPF2 SPAG17 DNAH8	2.46e-07	186	151	8	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ERBB3 INPP5B ITGB8 PNPLA6 SLFN13 PKP3 ATP2A3	1.97e-06	171	151	7	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OSTM1 TATDN2 PSMA8 JAK2 STARD9 SLC2A12 FAM43A	2.05e-06	172	151	7	3b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RNF144B ZFYVE16 TYMP CMIP CD163L1 MOB3B RUBCN	3.69e-06	188	151	7	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B ERBB4 MYO1E ITGB8 MOB3B DIAPH3 BBOX1	3.83e-06	189	151	7	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B ERBB4 MYO1E ITGB8 MOB3B DIAPH3 BBOX1	3.83e-06	189	151	7	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B ERBB4 MYO1E ITGB8 MOB3B DIAPH3 BBOX1	4.70e-06	195	151	7	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B ERBB4 MYO1E ITGB8 MOB3B DIAPH3 BBOX1	4.70e-06	195	151	7	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	LA-10._Endothelium_II\|World / Chamber and Cluster_Paper	RNF144B FLT4 CMIP PNPLA6 HMCN2 MCF2L	5.01e-06	128	151	6	071becbe97598c2b65580b0989eb664d6fd6c85a
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-dn_T\|Bac-SEP / Disease, condition lineage and cell class	SLC38A5 TMEM121 AP4S1 CD38 SCIN ATP2A3 FAM43A	5.37e-06	199	151	7	4150a479b80596accf679b37aa9b0ac15cc132b2
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC38A5 EMILIN1 RYR2 BOK SMPD1 LTBP2	1.29e-05	151	151	6	32d35906f4b2bd46b173e87f2dec972eb5da87b3
ToppCell	facs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 ERBB3 TMOD4 CD38 AHCY MOB3B	1.39e-05	153	151	6	0ef7c45cdd854c79e527006034029767f8e108b2
ToppCell	Bac-SEP-Lymphocyte-T_NK-dnT\|Bac-SEP / Disease, Lineage and Cell Type	SLC38A5 TMEM121 AP4S1 CD38 SCIN ATP2A3	1.79e-05	160	151	6	f5ca49801c981b903a85a64b21ece6b59fe91cbc
ToppCell	367C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RNF144B TPSD1 SLC8A2 CD163L1 SCIN	2.00e-05	97	151	5	a1279377bf0ee5662db8b9303f5f1fd418dee6df
ToppCell	367C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RNF144B TPSD1 SLC8A2 CD163L1 SCIN	2.00e-05	97	151	5	12cbd03b33e76e5e471bbee2a9c11f27e8b21123
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 MYO1E ABHD6 PKP3 CD38 FAM43A	2.69e-05	172	151	6	910ec7794ea4000db4ef1e2c34e08dbc0243df2c
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	GBP6 FZD6 PTPN13 CMIP CRYBG3 PLXNA2	2.97e-05	175	151	6	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CCNF POTEE POTEM DIAPH3 PLK1 ANKRD52	3.37e-05	179	151	6	021d782134126c6f7dce6b6ea50cc54bdaa39987
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT4 EMILIN1 RSPO3 BOK EFCC1 FAM43A	3.70e-05	182	151	6	2cc434e46985c66fc36de05344a67aa96d90abc9
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT4 EMILIN1 RSPO3 BOK EFCC1 FAM43A	3.70e-05	182	151	6	0cde2775bdaaa2172499925bd59b0ac2d545eb27
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT4 EMILIN1 RSPO3 BOK EFCC1 FAM43A	3.70e-05	182	151	6	3e7457b2a70b45735fb75d6617b7f34cef28758e
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT4 ZFYVE16 PTPN21 LRCH1 MCF2L DNAH8	4.17e-05	186	151	6	39e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT4 ZFYVE16 PTPN21 LRCH1 MCF2L DNAH8	4.17e-05	186	151	6	02418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCell	facs-Trachea-nan-3m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 LIPE CD38 MCF2L PLXNA2 FAM43A	4.56e-05	189	151	6	f60ac60ab9b317a0196f0cbbe520ef7dbd19ac11
ToppCell	facs-Trachea-nan-3m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 LIPE CD38 MCF2L PLXNA2 FAM43A	4.56e-05	189	151	6	e3d65417997bdd3f9c312c0977dceb6eca061029
ToppCell	facs-Trachea-nan-3m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 LIPE CD38 MCF2L PLXNA2 FAM43A	4.56e-05	189	151	6	5559af03d9d612bb8dcf825e45744a9f8332bac8
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 LIPE CD38 MCF2L PLXNA2 FAM43A	4.70e-05	190	151	6	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 LIPE CD38 MCF2L PLXNA2 FAM43A	4.70e-05	190	151	6	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 LIPE CD38 MCF2L PLXNA2 FAM43A	4.70e-05	190	151	6	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT4 LIPE CD38 MCF2L PLXNA2 FAM43A	4.70e-05	190	151	6	2655df8c0883dd811fa7617301f9c4b0a4dd55ec
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLT4 SLC38A5 FZD6 EFCC1 PLXNA2 FAM43A	5.12e-05	193	151	6	3f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GXYLT1 ST3GAL3 HPD MCF2L PLK1 ATP2A3	5.12e-05	193	151	6	6a9bce5064938b5b84ad57b4fd4a7841afe100c8
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ATR ZFYVE16 DENND1B CLTC CRYBG3 PUM1	5.12e-05	193	151	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B ERBB4 MYO1E ITGB8 DIAPH3 BBOX1	5.12e-05	193	151	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B ERBB4 MYO1E ITGB8 DIAPH3 BBOX1	5.12e-05	193	151	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD6 LIPE CD38 MCF2L PLXNA2 FAM43A	5.43e-05	195	151	6	98d79f6a8a5cc86a219efe8db9f9535d7ad4c5be
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD6 LIPE CD38 MCF2L PLXNA2 FAM43A	5.43e-05	195	151	6	ea0627ffe1750dbdd48006d251c0ba4cadd32faf
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD6 LIPE CD38 MCF2L PLXNA2 FAM43A	5.43e-05	195	151	6	3b95a989adb99591b44704ff4c496a1c6cb0bb18
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAB9B RYR2 JAK2 RSPO3 HMCN2 TMOD1	5.58e-05	196	151	6	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAB9B RYR2 JAK2 RSPO3 HMCN2 TMOD1	5.58e-05	196	151	6	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	KIF13B SLC38A5 EMILIN1 ITGB8 RYR2 LTBP2	5.74e-05	197	151	6	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	severe-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HDDC2 ATG2A ZBTB1 BOK SLFN13 CD38	6.24e-05	200	151	6	d6767f06fe13be8110a86c2a6029be2dd9ce666c
Drug	diazinon	POTED POTEC CES2 BOK PNPLA6 GSTCD SMPD1	3.28e-06	98	146	7	CID000003017
Drug	AC1L7AJI	ERBB4 FLT4 TYMP CES2 CCNF PTPN13 LIPE GSTCD SMPD1 PLK1	6.28e-06	256	146	10	CID000003750
Drug	Cgp77675	ERBB3 ERBB4 CLTCL1 JAK2 CLTC	8.01e-06	43	146	5	CID005311381
Drug	C12-NBD-PC	CLTCL1 SLC38A5 CLTC	8.87e-06	7	146	3	CID006439314
Disease	Squamous cell carcinoma of lung	ERBB4 ATR GUCY2F PLK1	1.29e-05	32	133	4	C0149782
Disease	lung adenocarcinoma (is_implicated_in)	ERBB3 ERBB4 JAK2 PTPN13	7.14e-05	49	133	4	DOID:3910 (is_implicated_in)
Disease	childhood onset asthma, age at onset, environmental tobacco smoke exposure measurement	KLHL1 NIN	2.99e-04	6	133	2	EFO_0004847, EFO_0008361, MONDO_0005405
Disease	vitamin supplement exposure measurement, Cleft palate, cleft lip, parental genotype effect measurement	KLHL1 RSPO3	5.55e-04	8	133	2	EFO_0003959, EFO_0005939, EFO_0009116, HP_0000175
Disease	heart disease (implicated_via_orthology)	RYR2 LIPE ATP2A3	6.73e-04	38	133	3	DOID:114 (implicated_via_orthology)
Disease	ductal carcinoma in situ (is_marker_for)	ERBB3 ERBB4 TYMP	7.27e-04	39	133	3	DOID:0060074 (is_marker_for)
Disease	nasopharynx carcinoma (is_marker_for)	ERBB3 ATR JAK2	9.68e-04	43	133	3	DOID:9261 (is_marker_for)
Disease	gallbladder neoplasm	ERBB3 ERBB4	1.08e-03	11	133	2	C0016978
Disease	Malignant neoplasm of gallbladder	ERBB3 ERBB4	1.08e-03	11	133	2	C0153452
Disease	stenosing tenosynovitis	KLHL1 LTBP2	1.29e-03	12	133	2	EFO_0010822
Disease	urinary bladder cancer (is_marker_for)	ERBB3 ERBB4 TYMP PLK1	1.42e-03	107	133	4	DOID:11054 (is_marker_for)
Disease	median neuropathy (biomarker_via_orthology)	ERBB3 ERBB4	1.77e-03	14	133	2	DOID:571 (biomarker_via_orthology)
Disease	asthma, body mass index	ERBB3 ITGB8	1.77e-03	14	133	2	EFO_0004340, MONDO_0004979
Disease	brain connectivity measurement	ERBB3 ERBB4 SLC25A26 LRCH1 RSPO3 DENND1B PLXNA2	2.30e-03	400	133	7	EFO_0005210
Disease	Benign neoplasm of stomach	ERBB3 ATR	2.62e-03	17	133	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB3 ATR	2.62e-03	17	133	2	C0496905
Disease	Carcinoma in situ of stomach	ERBB3 ATR	2.62e-03	17	133	2	C0154060
Disease	Eczema	ERBB3 ZNF652 ZBTB1 ITGB8 JAK2 ANKRD16	2.88e-03	310	133	6	HP_0000964
Disease	non-lobar intracerebral hemorrhage	ST3GAL3 ITGB8 FAM43A	2.92e-03	63	133	3	EFO_0010178
Disease	carcinoma (implicated_via_orthology)	ERBB3 ERBB4 FLT4	3.05e-03	64	133	3	DOID:305 (implicated_via_orthology)
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB3 ERBB4	3.28e-03	19	133	2	DOID:2876 (is_marker_for)
Disease	macrophage inflammatory protein 1b measurement	SCAP POLR1E SLFN11 SCIN	3.40e-03	136	133	4	EFO_0008219
Disease	susceptibility to mononucleosis measurement	RYR2 CMIP DNAH8	3.78e-03	69	133	3	EFO_0008403
Disease	Infiltrating duct carcinoma of female breast	ATR TESK2	4.00e-03	21	133	2	C3165106
Disease	Stomach Carcinoma	ERBB3 ATR	4.00e-03	21	133	2	C0699791
Disease	cardiomyopathy (implicated_via_orthology)	ERBB3 ERBB4 GATB	4.09e-03	71	133	3	DOID:0050700 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CQVELLENCGHSVVM	ABHD6	296	Q9BV23
CEVVMGNLEIVLTGH	ERBB3	56	P21860
CEVVMGNLEITSIEH	ERBB4	56	Q15303
VTALMDAIQCGHIDV	ANKRD16	206	Q6P6B7
RMSDEIVHNLDGCEI	CLSTN3	696	Q9BQT9
QEDMFVNHCVLEEGL	CRYBG3	2711	Q68DQ2
AVCQSIVHLFEDDMV	SMPD1	131	P17405
QIFMEAHCGQTELTE	BAZ2B	1181	Q9UIF8
CDDDGELFASMVHIL	CMIP	536	Q8IY22
VEAAVMTGLALNCHI	GATB	116	O75879
ACMDGHVEVARLLLD	ANKRD17	441	O75179
GHEKCALMILAETQD	ANKRD52	936	Q8NB46
GSLEENLFHEMETCL	CD163L1	1401	Q9NR16
IDECVSQIVLHRDGM	DIAPH3	461	Q9NSV4
QIHMCEEEEGDLLLF	DHX15	341	O43143
AQPAMVHALVDCLGE	BOK	141	Q9UMX3
HTLGELEACIAMLVE	EFCC1	451	Q9HA90
MFVVAEADAGSCLLH	ATP2A3	366	Q93084
TSMEVHFGQLEVLEC	ATG2A	511	Q2TAZ0
FAEAACDVVHVMLNG	CD38	196	P28907
ELNEMIHLACSDTFV	OR7A2P	181	Q8NGA2
QVLAVEEQLEHCMLG	RAB9B	171	Q9NP90
EEQLEHCMLGHTIDL	RAB9B	176	Q9NP90
THETQEECLGMAVLD	JAK2	171	O60674
CHEQEMVVSSLVIGA	SLC2A12	76	Q8TD20
DRVIVMGAEAHVNTC	MOB3B	171	Q86TA1
PDMVCLNHGTLQEAE	RNF144B	76	Q7Z419
HIILDEMVLNGCIVE	AP4S1	111	Q9Y587
CQEDECALMLLEHGT	POTEF	216	A5A3E0
CAEVPMVAFTLELQH	PNPLA6	791	Q8IY17
VAVMEDHLVQLLCEA	HMCN2	1541	Q8NDA2
TVDDLCQIMPELAHG	HECTD2	551	Q5U5R9
AGMAEQCLAVEALAE	HMGXB3	176	Q12766
AEQIVCEMGHALVGT	PLXNA2	911	O75051
EAFAMVTAGLCHDID	PDE6B	586	P35913
HPAMCLQDLTAVESE	CES2	91	O00748
NCHLGLEFMEELLET	DNAH8	3966	Q96JB1
IAQEAGHDLMDIFLC	ERAL1	411	O75616
MHLAVVACGERLEET	GXYLT1	116	Q4G148
DLGAALMDGVVLCHL	LRCH1	601	Q9Y2L9
TLEECGIVDSHVGML	LRRC14B	366	A6NHZ5
TDTLQELLDMHAACE	GBP6	346	Q6ZN66
IARDGLASCIHMEIE	LRGUK	501	Q96M69
GTHLCIDVEDAMNIT	OSTM1	251	Q86WC4
IEDVAHRMLATGECT	OSGEP	211	Q9NPF4
GVVILSEIMIACLEH	PTPN21	1116	Q16825
SEIMIACLEHNEVLD	PTPN21	1121	Q16825
VLIDEVCTMNDGPHS	PUM1	1096	Q14671
CQEDECVLMLLEHGA	POTEB3	216	A0JP26
CQEDECALMLLEHGT	POTEE	216	Q6S8J3
GFDAMLQAAVCESHI	ITGB8	256	P26012
VEMEHFLPLANLECS	FZD6	56	O60353
VQRLCSEMEELAEHG	CFAP298	41	P57076
SFEDHILEDLCGMLS	ATR	581	Q13535
CIHSEEEDMNLGLVR	CCNF	771	P41002
VSCAGITQDEFLLHM	HSD17B8	101	Q92506
SALIGGETQMHLLEC	GUCY2F	251	P51841
LAMEGSTCLDVFEHI	CYP4F8	181	P98187
ALMGSECLHKEVQDL	RAP1GDS1	561	P52306
LHAVDEELASSPVCM	GON4L	466	Q3T8J9
MACTIQKAEALDGAH	BBOX1	1	O75936
IEAAEALLHMESPTC	ELF2	96	Q15723
EGFQLDAAHMACVDV	LTBP2	1761	Q14767
ALVVAMHFECGDLLD	FAM43A	301	Q8N2R8
TDEIMHQDIVPLCAA	MCF2L	56	O15068
EHIRDCLDTGMIDNL	INPP5B	861	P32019
VRLALVHDMAECIVG	HDDC2	71	Q7Z4H3
AVIHGEAQCTELDMD	PRPSAP1	196	Q14558
DTVCVDLVMGQLAHS	EMILIN1	981	Q9Y6C2
IDHMQSELDNLECGD	DRC3	506	Q9H069
VCLSQAIMLGFDSHE	DOK7	81	Q18PE1
FSHILIDEAAQMLEC	HELZ2	661	Q9BYK8
EDIGLLHEVVSLCHM	DENND1B	741	Q6P3S1
SDAHVTAMLQCLEAV	RUBCN	161	Q92622
HMLAASAGEVVACLI	SLC25A26	91	Q70HW3
AGCLHMTVETAVLIE	AHCY	51	P23526
VLRGHLMDIECLASD	SCAP	771	Q12770
LLDFHEDLMTHCGIE	RYR2	1996	Q92736
VQLSDACDMLGVHIV	SLFN13	836	Q68D06
ACDMLGVHIVLDSVR	SLFN13	841	Q68D06
VALHACGVATDMVIE	GSTCD	511	Q8NEC7
DMETSHGICRIAVAL	IPO13	301	O94829
LPDEVEHCQSILFSM	PHKA2	231	P46019
VHIVACALDPMLDDS	LIPE	986	Q05469
DDIGAALMDGVVLCH	LRCH2	666	Q5VUJ6
DHLNSILLGMCEDVI	PTPN13	126	Q12923
LACADTHINEVMVLA	OR2A25	186	A4D2G3
SEELSCEMEGNLEHL	PCARE	816	A6NGG8
VATLHPCMSDVAEDL	UPF2	626	Q9HAU5
CQEDECVLMLLEHGA	POTEC	216	B2RU33
CQEDECVLMLLEHGA	POTED	216	Q86YR6
MIEENSHCTFVIEAL	POLR1E	246	Q9GZS1
CSLEMIDHIVGNQPD	HPD	176	P32754
EHCIIDITSEGQVML	KIF13B	491	Q9NQT8
DISQMLVCTADGDIH	TAF7L	176	Q5H9L4
LAAAQGLAHMIMECD	STARD13	851	Q9Y3M8
IVRDDMLCAGSENHD	TPSD1	211	Q9BZJ3
EHCETVFGMLLGDTI	SMCHD1	1821	A6NHR9
LEEGFIDTHCHLDML	TATDN2	491	Q93075
GSLGQEELTDLCHML	NIN	26	Q8N4C6
HSLEEQQVCMAVDIG	NBPF8	551	Q3BBV2
HSLEEQQVCMAVDIG	NBPF9	586	P0DPF3
HSLEEQQVCMAVDIG	NBPF10	586	Q6P3W6
HSLEEQQVCMAVDIG	NBPF11	586	Q86T75
HSLEEQQVCMAVDIG	NBPF14	246	Q5TI25
HSLEEQQVCMAVDIG	NBPF26	246	B4DH59
CAIGHNETAMESEAL	SLC38A5	221	Q8WUX1
MLLSEECFILDHGAA	SCIN	276	Q9Y6U3
VLTLTDDHEFMVIAC	PPM1G	426	O15355
AVTMALHGCDEVAVA	ST3GAL3	306	Q11203
VQLSDACDMLGDHIV	SLFN11	836	Q7Z7L1
ACDMLGDHIVLDSVR	SLFN11	841	Q7Z7L1
DVAAVVMQEGLAHIC	PELO	136	Q9BRX2
CQEDECALMLLEHGT	POTEI	216	P0CG38
PSDHASMCLAILEEI	STARD9	2541	Q9P2P6
MCEVGAVLADIGQHV	ABCC12	836	Q96J65
ILHCMLEQVVATEED	SPAG17	446	Q6Q759
TDVSQLEGHFDIVMC	CAMKMT	216	Q7Z624
MCGLHIVVHADELEE	CLTC	1271	Q00610
EDSVECLHAMLSANI	CLTCL1	661	P53675
NCVEMGAHLVVFNTE	CLEC6A	106	Q6EIG7
MRECHGLVDALVTSI	PKP3	496	Q9Y446
VVSGFDVDHGICIMD	WDR88	201	Q6ZMY6
DVDHGICIMDAENIT	WDR88	206	Q6ZMY6
AELCDIAAILGMHTL	TMOD1	126	P28289
GLVCETMEEARHIAL	SMC1B	616	Q8NDV3
CVALSEVSMQGEHIA	TMEM121	196	Q9BTD3
VHMALCAVNLAECAE	SREBF2	691	Q12772
VSDSLEMQCLVAGAH	FLT4	691	P35916
ECTAIDGLSLDQTHM	EXT2	656	Q93063
CLEAAMIEGEIESLH	USP25	336	Q9UHP3
EGLEANNHTMECVSI	RSPO3	131	Q9BXY4
AVNQMVDELIECGHT	SPTBN4	1786	Q9H254
VDELIECGHTAAATM	SPTBN4	1791	Q9H254
TVLMAGAHCVALVDQ	SERPINA13P	11	Q6UXR4
MLVALEALHEQGVLC	RPS6KL1	396	Q9Y6S9
VEEMNVCDNLGDHLV	U2AF1	96	Q01081
IEEMNVCDNLGDHLV	U2AF1L4	96	Q8WU68
AHATDAEMCDIAAIL	TMOD4	121	Q9NZQ9
ENLVVEHMSSCLDQD	ZBTB1	546	Q9Y2K1
AECEEVIMGHLSLNS	ZNF563	106	Q8TA94
DDHVILMDCTVSTGA	UCKL1	446	Q9NWZ5
ALDDHVCMAFAVLTI	PSMA8	66	Q8TAA3
AAQAHEAMDCSILQE	TESK2	506	Q96S53
LVENCAVHVAGMAQE	ZNF652	11	Q9Y2D9
LCSHMEAAADGELET	TCFL5	61	Q9UL49
CQEDECALMLLEHGT	POTEM	216	A6NI47
LECDGAIMIHCSLNI	TMEM78	111	Q5T7P6
VGHALEVEEALLCMD	TYMP	281	P19971
ICDLISDMGNLVHAT	ZFYVE16	126	Q7Z3T8
MQDVHTKSIACDGDL	HSD52	1	Q0P140
TGEVVDCHLSDMLQQ	PLK1	366	P53350
LNICEEMTILHGGFL	GEMIN4	6	P57678
TLIGDVCVLEDMTVH	HECTD3	331	Q5T447
ADAQGCIELMKVAHS	KLHL1	321	Q9NR64
LLHVSECMGTVDVRV	SLC8A2	531	Q9UPR5
SILDDVCATMHAVGE	MYO1E	461	Q12965