Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	WTX	AMER2 AMER3	5.02e-05	3	77	2	PF09422
Domain	Uncharacterised_FAM123	AMER2 AMER3	5.02e-05	3	77	2	IPR019003
Domain	WW	HECW2 ARHGAP27 CEP164	1.02e-03	48	77	3	SM00456
Domain	CRAL_TRIO_2	PRUNE2 MCF2L2	1.08e-03	12	77	2	PF13716
Domain	WW_DOMAIN_2	HECW2 ARHGAP27 CEP164	1.22e-03	51	77	3	PS50020
Domain	WW_DOMAIN_1	HECW2 ARHGAP27 CEP164	1.22e-03	51	77	3	PS01159
Domain	WW_dom	HECW2 ARHGAP27 CEP164	1.29e-03	52	77	3	IPR001202
Domain	ZF_DAG_PE_1	STAC2 AKAP13 ARHGAP45	2.34e-03	64	77	3	PS00479
Domain	ZF_DAG_PE_2	STAC2 AKAP13 ARHGAP45	2.34e-03	64	77	3	PS50081
Domain	C1	STAC2 AKAP13 ARHGAP45	2.45e-03	65	77	3	SM00109
Domain	PE/DAG-bd	STAC2 AKAP13 ARHGAP45	2.56e-03	66	77	3	IPR002219
Domain	PDZ	DVL1P1 PARD3 PDZRN3 PDZD4	2.75e-03	141	77	4	PF00595
Domain	PDZ	DVL1P1 PARD3 PDZRN3 PDZD4	3.27e-03	148	77	4	SM00228
Domain	PDZ	DVL1P1 PARD3 PDZRN3 PDZD4	3.52e-03	151	77	4	PS50106
Domain	PDZ	DVL1P1 PARD3 PDZRN3 PDZD4	3.60e-03	152	77	4	IPR001478
Domain	-	PRUNE2 MCF2L2	4.01e-03	23	77	2	3.40.525.10
Domain	SEC14	PRUNE2 MCF2L2	4.73e-03	25	77	2	SM00516
Domain	Bromodomain_CS	BAZ1B BRD3	5.11e-03	26	77	2	IPR018359
Domain	CRAL_TRIO	PRUNE2 MCF2L2	5.51e-03	27	77	2	PS50191
Domain	CRAL-TRIO_dom	PRUNE2 MCF2L2	5.92e-03	28	77	2	IPR001251
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	PRUNE2 OXR1 FIG4 NBEA RB1CC1 AP3B1 DENND1A DMXL1	2.63e-07	285	78	8	34369648
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	STIM2 WFS1 POLE EIF5B KIAA1549 BAZ1B CHCHD6 AKAP13 RB1CC1 EPB41L3 EIF4G3 PARD3 AP3B1 DMXL1 PCNT	9.39e-07	1487	78	15	33957083
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 ZNF106 LEO1 CLN3 EIF5B BAZ1B ACIN1 BRD3 RERE PARD3 PNISR	1.24e-06	774	78	11	15302935
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	CSDE1 ZNF106 SALL2 CDKN2AIP DACH1 BAZ1B EPB41L3 ZHX2	7.11e-06	444	78	8	34795231
Pubmed	BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain.	PRUNE2 AKAP13	1.49e-05	3	78	2	18445682
Pubmed	The WTX/AMER1 gene family: evolution, signature and function.	AMER2 AMER3	1.49e-05	3	78	2	20843316
Pubmed	Expression patterns of the Wtx/Amer gene family during mouse embryonic development.	AMER2 AMER3	1.49e-05	3	78	2	20503382
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 CSDE1 POLE EIF5B BAZ1B ACIN1 EPB41L3 EIF4G3 PCNT	1.58e-05	653	78	9	22586326
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DHX16 CSDE1 LEO1 SUDS3 CDKN2AIP POLE EIF5B BAZ1B ACIN1 BRD3 XRCC1	1.60e-05	1014	78	11	32416067
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	LEO1 BAZ1B ACIN1 BRD3 PNISR PCNT	2.21e-05	251	78	6	31076518
Pubmed	Centrosome anchoring regulates progenitor properties and cortical formation.	PARD3 CEP164 PCNT	2.41e-05	25	78	3	32238932
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	DACH1 EIF5B BAZ1B ACIN1 BRD3 XRCC1 AP3B1 ARHGAP45	2.64e-05	533	78	8	30554943
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CSDE1 CDKN2AIP EIF5B BAZ1B BRD3 XRCC1 EIF4G3 PARD3 AP3B1 ZHX2 PNISR DENND1A CEP164	2.68e-05	1497	78	13	31527615
Pubmed	Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.	DHX16 CSDE1 RIN1 OXR1 XRCC1	3.21e-05	161	78	5	32572027
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	DHX16 LEO1 SUDS3 EIF5B ACIN1	3.41e-05	163	78	5	22113938
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DHX16 CSDE1 ACSL6 ACIN1 RERE ZHX2 PCNT	3.69e-05	407	78	7	12693553
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	DHX16 STAC2 SEC62 RERE XRCC1 EPB41L3 ZHX2 PDZD4	6.67e-05	608	78	8	16713569
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	CSDE1 STIM2 SEC62 BAZ1B EPB41L3	7.23e-05	191	78	5	31177093
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	SEC62 EIF5B BAZ1B ACIN1 BRD3	7.23e-05	191	78	5	20195357
Pubmed	Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.	BAZ1B GCKR	7.40e-05	6	78	2	20802025
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CSDE1 ACSL6 MCF2L2 ZHX2	7.79e-05	100	78	4	10048485
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CSDE1 ACSL6 RIN1 OXR1 WFS1 HECW2 IQSEC2 KIAA1549 NBEA EPB41L3 EIF4G3 AP3B1	7.91e-05	1431	78	12	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STIM2 LEO1 DZIP1L SEC62 EIF5B ACIN1 BRD3 GPR101 EPB41L3 EIF4G3 PNISR PCNT	8.50e-05	1442	78	12	35575683
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	DTD1 LRRC8C EIF5B CHCHD6 PARD3 GNL1 DMXL1	9.72e-05	475	78	7	31040226
Pubmed	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.	BAZ1B GCKR	1.04e-04	7	78	2	20657596
Pubmed	The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling.	LRRC8C STIM2	1.04e-04	7	78	2	35105987
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DHX16 CSDE1 HAUS7 LEO1 CDKN2AIP IQSEC2 EIF5B AP3B1 PNISR DENND1A	1.08e-04	1038	78	10	26673895
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	DHX16 CSDE1 LEO1 SUDS3 SEC62 BAZ1B AP3B1 GNL1	1.09e-04	653	78	8	33742100
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CSDE1 PRUNE2 RPH3AL CHCHD6 AKAP13 RERE EIF4G3 PARD3 ZHX2 DENND1A SBNO2 PCNT	1.15e-04	1489	78	12	28611215
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	EIF5B NBEA XRCC1 EPB41L3 EIF4G3 AP3B1 GNL1	1.30e-04	498	78	7	36634849
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	RIN1 AMER2 OXR1 NBEA EPB41L3 EIF4G3	1.33e-04	347	78	6	17114649
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RIN1 LEO1 EIF5B ACIN1 AKAP13 EPB41L3 EIF4G3	1.38e-04	503	78	7	16964243
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	DHX16 CSDE1 ACIN1 XRCC1 RB1CC1 PCNT	1.62e-04	360	78	6	33111431
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DNAAF2 RIN1 LEO1 GOLGA6L2 IQSEC2 EIF5B STYXL2 CHCHD6 PARD3 AP3B1 DENND1A	1.72e-04	1321	78	11	27173435
Pubmed	Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.	POLE XRCC1	1.77e-04	9	78	2	20227374
Pubmed	Role of minor histocompatibility antigens in renal transplantation.	AKAP13 ARHGAP45	1.77e-04	9	78	2	18093280
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX16 CSDE1 RIN1 POLE EIF5B BAZ1B ACIN1 CHCHD6 AKAP13 EPB41L3 PARD3	2.11e-04	1353	78	11	29467282
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	DHX16 MCF2L2 KIAA1549 EPB41L3	2.15e-04	130	78	4	12421765
Pubmed	Cell polarity and spindle orientation in the distal epithelium of embryonic lung.	PARD3 PCNT	2.21e-04	10	78	2	21246661
Pubmed	Common variants at 1p36 are associated with superior frontal gyrus volume.	STIM2 EIF4G3	2.21e-04	10	78	2	25335168
Pubmed	Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development.	CEP164 PCNT	2.70e-04	11	78	2	33410253
Pubmed	HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.	PARD3 PCNT	2.70e-04	11	78	2	28994651
Pubmed	Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.	PARD3 PCNT	3.23e-04	12	78	2	23406901
Pubmed	Telophase correction refines division orientation in stratified epithelia.	PARD3 PCNT	3.23e-04	12	78	2	31833472
Pubmed	Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.	C2CD4B GCKR	3.23e-04	12	78	2	20185807
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	FIG4 E2F7 CHCHD6 PARD3 ZHX2	3.32e-04	265	78	5	19240061
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	HAUS7 CDKN2AIP POLE ACIN1 EPB41L3 AP3B1 PCNT	3.36e-04	582	78	7	20467437
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CSDE1 LRRC8C STIM2 WFS1 SEC62 LEMD2 LAMA4 KIAA1549 EIF4G3 DMXL1	3.47e-04	1201	78	10	35696571
Pubmed	Replication of recently described type 2 diabetes gene variants in a South Indian population.	WFS1 BAZ1B	3.81e-04	13	78	2	20580033
Pubmed	Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.	CEP164 PCNT	3.81e-04	13	78	2	17920017
Pubmed	CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.	CEP164 PCNT	4.44e-04	14	78	2	32060285
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	DHX16 DACH1 BAZ1B ACIN1 XRCC1	4.48e-04	283	78	5	30585729
Pubmed	Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.	DACH1 BAZ1B GCKR	4.69e-04	67	78	3	23263486
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	LEO1 CDKN2AIP KIAA1549 NBEA BRD3 XRCC1 RB1CC1 AP3B1 PCNT	5.65e-04	1049	78	9	27880917
Pubmed	Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly.	PARD3 PCNT	5.84e-04	16	78	2	32501282
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	GCKR SBNO2	5.84e-04	16	78	2	19068216
Pubmed	Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain.	PARD3 PCNT	5.84e-04	16	78	2	21736876
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	POLE E2F7 ACIN1 AKAP13 XRCC1 RB1CC1 EPB41L3 EIF4G3 PARD3 AP3B1	5.85e-04	1284	78	10	17353931
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX16 CSDE1 LEO1 POLE AKAP13 AP3B1 SBNO2	6.47e-04	650	78	7	38777146
Pubmed	Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.	C2CD4B WFS1 GCKR	6.52e-04	75	78	3	20571754
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CSDE1 SUDS3 CDKN2AIP LEMD2 EIF5B ACIN1 RERE	6.77e-04	655	78	7	35819319
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ZNF106 STIM2 IQSEC2 AKAP13 EPB41L3 EIF4G3 PARD3 DENND1A	6.95e-04	861	78	8	36931259
Pubmed	Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?	AKAP13 RERE	7.42e-04	18	78	2	26921296
Pubmed	Functional genomics analysis identifies loss of HNF1B function as a cause of Mayer-Rokitansky-Küster-Hauser syndrome.	DACH1 LAMA4	7.42e-04	18	78	2	36282544
Pubmed	Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.	PARD3 PCNT	7.42e-04	18	78	2	29229865
Pubmed	Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.	ACIN1 XRCC1 ZHX2	7.59e-04	79	78	3	14729942
Pubmed	A human MAP kinase interactome.	CSDE1 ZNF106 LAMA4 AKAP13 EPB41L3 PNISR	7.93e-04	486	78	6	20936779
Pubmed	Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.	POLE PARD3	8.28e-04	19	78	2	14671302
Pubmed	MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.	PARD3 PCNT	8.28e-04	19	78	2	19666823
Pubmed	The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.	CEP164 PCNT	8.28e-04	19	78	2	24421332
Pubmed	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	BAZ1B GCKR	8.28e-04	19	78	2	19656773
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 STIM2 FIG4 EIF5B EPB41L3 PDZRN3	8.54e-04	493	78	6	15368895
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SALL2 SUDS3 KIAA1549 BAZ1B BRD3 RERE EPB41L3 PARD3 PDZRN3	8.76e-04	1116	78	9	31753913
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	FIG4 RB1CC1 ARHGAP45	8.76e-04	83	78	3	9039502
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	DHX16 RB1CC1 EIF4G3 AP3B1 DMXL1	8.82e-04	329	78	5	34316702
Pubmed	New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.	C2CD4B GCKR	9.19e-04	20	78	2	20081858
Pubmed	Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.	PARD3 PCNT	9.19e-04	20	78	2	26876178
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DHX16 DTD1 CSDE1 WFS1 SEC62 ACIN1 PARD3 AP3B1 DENND1A GNL1	9.66e-04	1371	78	10	36244648
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SALL2 NBEA RB1CC1	1.00e-03	87	78	3	12465718
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CSDE1 AMER2 STIM2 WFS1 SEC62 IQSEC2 NBEA EPB41L3 EIF4G3	1.01e-03	1139	78	9	36417873
Pubmed	SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.	PARD3 PCNT	1.01e-03	21	78	2	33332551
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	SUDS3 EIF5B BAZ1B ACIN1 XRCC1	1.03e-03	341	78	5	32971831
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CSDE1 STIM2 EIF5B EPB41L3 EIF4G3 PARD3 AP3B1	1.06e-03	708	78	7	39231216
Pubmed	EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.	PARD3 PCNT	1.11e-03	22	78	2	34001891
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CSDE1 CDKN2AIP EIF5B BAZ1B ACIN1 EPB41L3 EIF4G3 PCNT	1.17e-03	934	78	8	33916271
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LRRC8C HECW2 IQSEC2 AKAP13 NBEA BRD3 AMER3	1.33e-03	736	78	7	29676528
Pubmed	RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.	DHX16 AP3B1	1.44e-03	25	78	2	31636387
Pubmed	Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.	WFS1 GCKR	1.44e-03	25	78	2	20879858
Pubmed	Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.	POLE XRCC1	1.44e-03	25	78	2	20226869
Pubmed	A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis.	PARD3 PCNT	1.44e-03	25	78	2	29587143
Pubmed	Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse.	DZIP1L CEP164	1.44e-03	25	78	2	29487109
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CSDE1 DACH1 BAZ1B ACIN1 PARD3 AP3B1	1.48e-03	549	78	6	38280479
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIAA1549 NBEA DENND1A	1.54e-03	101	78	3	10997877
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	POLE FXYD1	1.56e-03	26	78	2	23435420
Pubmed	PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia.	PARD3 PCNT	1.56e-03	26	78	2	29899142
Pubmed	Dual function of Yap in the regulation of lens progenitor cells and cellular polarity.	PARD3 PCNT	1.56e-03	26	78	2	24384391
Pubmed	Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression.	CSDE1 CDKN2AIP IQSEC2	1.59e-03	102	78	3	31623628
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	BAZ1B ACIN1 BRD3	1.63e-03	103	78	3	32744500
Pubmed	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.	STAC2 WFS1	1.68e-03	27	78	2	37995181
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	WFS1 GCKR	1.68e-03	27	78	2	20490451
Interaction	CAMKV interactions	DTD1 DNAAF2 ACIN1 BRD3 AP3B1 PNISR	5.99e-06	118	77	6	int:CAMKV
Coexpression	LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2	PRUNE2 OXR1 AKAP13 NBEA RERE EIF4G3 PARD3	8.08e-07	176	76	7	M39223
Coexpression	LAKE_ADULT_KIDNEY_C3_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S1_S2	PRUNE2 AKAP13 RERE EPB41L3 PARD3 PNISR DENND1A	3.68e-06	221	76	7	M39222
Coexpression	MURARO_PANCREAS_BETA_CELL	CSDE1 PRUNE2 ZNF106 RPH3AL WFS1 HS6ST1 NBEA RERE EPB41L3 EIF4G3 AP3B1 PDZRN3	1.69e-05	946	76	12	M39169
Coexpression	TERAO_AOX4_TARGETS_SKIN_DN	ACSL6 CFAP70 DMXL1	3.98e-05	23	76	3	M2363
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	DNAAF2 ZNF106 LEO1 POLE DACH1 EIF5B E2F7 ACIN1 ZHX2 PCNT	1.72e-05	532	75	10	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 DACH1 AKAP13 RERE EPB41L3 PARD3 DENND1A	4.72e-08	192	78	7	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MCF2L2 AKAP13 RERE EPB41L3 EIF4G3 ZHX2 DENND1A	4.89e-08	193	78	7	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Pericytes-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	PRUNE2 STAC2 SUSD5 LAMA4 FXYD1 PDZRN3	6.47e-07	175	78	6	ddf721023a7afc8085c5de17aa254a6575444c0f
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	NBEA RERE EIF4G3 PARD3 ZHX2 DENND1A	1.37e-06	199	78	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRC8C ACSL6 STAC2 CLN3 PDZD4	4.78e-06	140	78	5	7b359bfbd404ab06d799048252f4985d85852048
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SUSD5 CLN3 POLE NBEA PDZD4	9.43e-06	161	78	5	9703b7e67d9fadb6129cad166bd01be915042e44
ToppCell	Pericytes-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	STAC2 SUSD5 LAMA4 FXYD1 PDZRN3	1.80e-05	184	78	5	cd10d351d91a81dd6dc806cb4e0c8d7861c98e0b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 OXR1 KIAA1549 PARD3 DENND1A	1.94e-05	187	78	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 C2CD4B WFS1 AKAP13 EPB41L3	2.15e-05	191	78	5	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HECW2 DACH1 LAMA4 FXYD1 PDZRN3	2.26e-05	193	78	5	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 LAMA4 STYXL2 FXYD1 PDZRN3	2.43e-05	196	78	5	5159d8625d80c20eb28157b2603c8bde9d377a35
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 LAMA4 STYXL2 FXYD1 PDZRN3	2.43e-05	196	78	5	6b5b7dbcb2cce8a736e44145a01290905876a5e9
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MCF2L2 KCNK13 AMER3 EPB41L3 DENND1A	2.49e-05	197	78	5	e2983ae16c72371fbf0e5c123de9f4d900724e5e
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SALL2 LAMA4 FXYD1 PDZRN3 ZNF697	2.68e-05	200	78	5	29054cf55e88e1ac81a562d8dd9af9b7c749321d
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; PC3; HT_HG-U133A	CLN3 BAZ1B ACIN1 AKAP13 PARD3 PNISR SBNO2	4.21e-06	199	75	7	6324_DN
Disease	level of Sterol ester (27:1/16:1) in blood serum	GCKR DENND1A	2.27e-04	9	75	2	OBA_2045190
Disease	ceramide measurement	ZNF106 STAC2 OXR1 GCKR ARHGAP45	3.37e-04	235	75	5	EFO_0010222
Disease	phosphatidylcholine 34:4 measurement	DACH1 GCKR	4.14e-04	12	75	2	EFO_0010378
Disease	insulin resistance	C2CD4B GCKR AP3B1	4.63e-04	59	75	3	EFO_0002614
Disease	superior frontal gyrus grey matter volume measurement	STIM2 EIF4G3	5.69e-04	14	75	2	EFO_0006516
Disease	neutrophil count	PRUNE2 STAC2 OXR1 IQSEC2 AKAP13 BRD3 GCKR RERE ARHGAP45 SBNO2 PCNT	7.12e-04	1382	75	11	EFO_0004833
Disease	triacylglycerol 50:5 measurement	DACH1 GCKR	7.48e-04	16	75	2	EFO_0010412
Disease	protein C measurement	BAZ1B GCKR	8.46e-04	17	75	2	EFO_0004633
Disease	uric acid measurement	LRRC8C DACH1 BAZ1B AKAP13 GCKR EPB41L3 ZNF697	9.18e-04	610	75	7	EFO_0004761
Disease	Hypertriglyceridemia	BAZ1B GCKR	1.06e-03	19	75	2	EFO_0004211
Disease	alcohol consumption measurement	DTD1 CLN3 EIF5B NBEA BRD3 GCKR RERE ARHGAP27 PARD3 DENND1A	1.16e-03	1242	75	10	EFO_0007878
Disease	triacylglycerol 48:3 measurement	DACH1 GCKR	1.42e-03	22	75	2	EFO_0010406
Disease	neuroimaging measurement	ZNF106 STAC2 AMER2 RERE ARHGAP27 PARD3 ZHX2 DENND1A PDZRN3	1.53e-03	1069	75	9	EFO_0004346
Disease	BMI-adjusted fasting blood glucose measurement	C2CD4B GCKR	1.56e-03	23	75	2	EFO_0008036
Disease	carnosine measurement	OXR1 AP3B1	1.70e-03	24	75	2	EFO_0010470
Disease	triacylglycerol 52:6 measurement	DACH1 GCKR	1.84e-03	25	75	2	EFO_0010418
Disease	alcohol use disorder measurement, alcohol consumption measurement	DTD1 CLN3 GCKR	1.96e-03	97	75	3	EFO_0007878, EFO_0009458
Disease	docosapentaenoic acid measurement	STIM2 GCKR	2.15e-03	27	75	2	EFO_0006809
Disease	Ischemic stroke, factor VII measurement	GCKR PARD3	2.48e-03	29	75	2	EFO_0004619, HP_0002140

Protein segments in the cluster

Peptide	Gene	Start	Entry
RISEDETERNGDDGT	ACIN1	896	Q9UKV3
GTGTLSRDASREEET	AMER3	591	Q8N944
GSSDSEEERATRLAE	BRD3	451	Q15059
GEVRTAEDASRTGAV	AMER2	311	Q8N7J2
DTERSAFTERDSGSG	ALG1L2	51	C9J202
LRRSDVQEESEGSDT	BAZ1B	696	Q9UIG0
EGDDGQDLRRTESDS	AKAP13	2486	Q12802
GDDVEFEVSSDRRTG	CSDE1	66	O75534
EDSEESSEETVSRAG	DHX16	101	O60231
EADRSGGRTDAERTI	DACH1	731	Q9UI36
TDIGESRDRSQGGET	DMXL1	1521	Q9Y485
SSEQDSESGRESGLE	AP3B1	721	O00203
VGRTDESTRNDESSE	PDZRN3	571	Q9UPQ7
ADSTVSEESSERDAG	KIAA1549	1416	Q9HCM3
SSEEDSEGDRVQRVS	DZIP1L	616	Q8IYY4
DASGGSRRAVSETES	HECW2	586	Q9P2P5
SDRSAVETADEGRVD	RB1CC1	1421	Q8TDY2
SESARGSDSEDEVLR	LEO1	271	Q8WVC0
SRGRQDGSESEAVAV	ARHGAP45	871	Q92619
ARGDSSVETREESEG	DNAAF2	486	Q9NVR5
RRASVRGSSEEDEDA	LEMD2	131	Q8NC56
DEDRSNTGERSNTGE	SPINK5	826	Q9NQ38
DSSVDLSDRSDRGSV	IQSEC2	601	Q5JU85
STDEAADAESGTRNR	CDKN2AIP	56	Q9NXV6
SVSSGNEDEERRAGS	C2CD4B	201	A6NLJ0
EEETATRSTEEERAG	MCF2L2	1071	Q86YR7
LDSGVGRTDESTRNE	PDZD4	276	Q76G19
GEPDEEEGTFRSSIR	FXYD1	71	O00168
GDAREGGEDTRSERE	GOLGA6L2	871	Q8N9W4
GGEDTRSEREDAGEA	GOLGA6L2	876	Q8N9W4
RERREEQTDTSDGES	GNL1	41	P36915
GVAESDTDGRRLSGE	KCNK13	331	Q9HB14
DGEASRDDGATSSVS	POLE	16	Q07864
SSVEARGSEEVRESS	GPR101	296	Q96P66
RGSEEVRESSTVASD	GPR101	301	Q96P66
SRGEATATDAEAREA	PCNT	1391	O95613
STRAGGVEVDEDTIR	HS6ST1	321	O60243
GDRSVVASREGTEDS	GCKR	141	Q14397
GSNTEEIDSRIRDAG	OXR1	306	Q8N573
EDRSASSGAEGDVSS	DTD1	191	Q8TEA8
ASGSGSERDDRSSEA	E2F7	566	Q96AV8
DSGTDREEEGSVSQR	FIG4	761	Q92562
STGVEDTEERGKRES	CFAP70	781	Q5T0N1
SEDEGDSSVSRAAVE	HAUS7	16	Q99871
RTLRESDSAEGDEAE	DENND1A	531	Q8TEH3
SRGPEEEETGSREDR	KIRREL2	561	Q6UWL6
ERRAAGSGDSDSESD	DVL1P1	566	P54792
DVTDEDSLAGRGSES	SALL2	776	Q9Y467
TGGVDVERNSTEAER	EIF4G3	1181	O43432
RSSAINEEDGSSEEG	MENT	96	Q9BUN1
DSERTDTAADGETTA	EPB41L3	691	Q9Y2J2
ETLEEDTEESSRSGR	PARD3	946	Q8TEW0
SSDEAVADTSRRVGG	LAMA4	686	Q16363
ARGRVVSSDSDSDSD	RPH3AL	201	Q9UNE2
DSRTEADEDRGQGDS	SUSD5	226	O60279
EEGSGQSEARSRGEE	RIN1	716	Q13671
EDARVISTSSGSDDD	PRUNE2	1676	Q8WUY3
SSEGRRVSFGVDEEE	CHCHD6	6	Q9BRQ6
ERSRINSSGESGDES	EIF5B	176	O60841
DAGSIISDTERSDDG	NBEA	1256	Q8NFP9
EESESSRVDFGSSER	ARHGAP27	621	Q6ZUM4
STGEARTREVLGEND	SBNO2	576	Q9Y2G9
SEGEGESSDSRSVND	RERE	681	Q9P2R6
SEEVEDSGGARRSVI	ACSL6	61	Q9UKU0
TVDAGEEGSRREEAA	CEP164	351	Q9UPV0
GSRRRFSDSEGEETV	CLN3	6	Q13286
GGERHSDTDSDRRED	SEC62	336	Q99442
SRDEVSLEDSSRGDS	STIM2	626	Q9P246
SEDGREDETTDTQRG	TEX54	21	A0A1B0GVG6
GEEEEERRSSAAGKS	TBX22	41	Q9Y458
EKEEESDAGSSVGRR	STYXL2	416	Q5VZP5
REEAADRSSEAGSRV	STYXL2	501	Q5VZP5
DRSSEAGSRVREDDE	STYXL2	506	Q5VZP5
AGSRVREDDEDSVGS	STYXL2	511	Q5VZP5
RSLSERDELTEDGEG	STAC2	231	Q6ZMT1
RDELTEDGEGSIRSS	STAC2	236	Q6ZMT1
SSGSEDESEDGMRTR	USB1	11	Q9BQ65
SISRSLREDDDESAG	ZNF697	111	Q5TEC3
EATSDRSEGSSRDGQ	ZHX2	766	Q9Y6X8
VTVGEEDAISDRSDS	ZHX2	796	Q9Y6X8
GAEDSGDTEDELRRV	XRCC1	481	P18887
SEDERSDRGSESSDT	PNISR	396	Q8TF01
RGRESDEDTEDASET	SUDS3	41	Q9H7L9
SGSTRTADEKEEDDR	ZNF106	616	Q9H2Y7
GADGSRSREEDDVTK	WFS1	786	O76024
TTRALSEVSGEDSEE	LRRC8C	171	Q8TDW0