Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

CDX2 WIZ HOXD8 HOXD13 ZIC5 EBF3 GATA6 SP9 ZFHX3 EBF1 EMX2 RXRB RXRG EBF4 ZNF697

1.90e-0614125215GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

CDX2 WIZ HOXD13 ZIC5 EBF3 GATA6 SP9 ZFHX3 EBF1 EMX2 RXRB RXRG EBF4 ZNF697

2.33e-0612445214GO:0000978
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

CDX2 WIZ HOXD8 HOXD13 ZIC5 EBF3 GATA6 SP9 ZFHX3 EBF1 EMX2 RXRB RXRG EBF4 ZNF697

2.85e-0614595215GO:0000977
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

CDX2 WIZ HOXD13 ZIC5 EBF3 GATA6 SP9 ZFHX3 EBF1 EMX2 RXRB RXRG EBF4 ZNF697

3.00e-0612715214GO:0000987
GeneOntologyMolecularFunctionretinoic acid-responsive element binding

RXRB RXRG

1.39e-047522GO:0044323
GeneOntologyMolecularFunctionnuclear steroid receptor activity

RXRB RXRG

1.92e-0325522GO:0003707
GeneOntologyMolecularFunctionmethyltransferase activity

ASMT DOT1L METTL17 TRMT61A

2.28e-03213524GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

ASMT DOT1L METTL17 TRMT61A

2.74e-03224524GO:0016741
GeneOntologyBiologicalProcessresponse to retinoic acid

WNT3 WNT6 GATA6 RXRB RXRG

1.96e-05131525GO:0032526
GeneOntologyCellularComponentchromatin

CDX2 HOXD8 HOXD13 EBF3 GATA6 SP9 ZFHX3 EBF1 ARID1A EMX2 RXRB RXRG EBF4

6.18e-0514805313GO:0000785
GeneOntologyCellularComponentribonuclease MRP complex

POP5 RPP25L

2.24e-049532GO:0000172
DomainTranscription_factor_COE

EBF3 EBF1 EBF4

8.61e-084533IPR003523
DomainCOE1_HLH

EBF3 EBF1 EBF4

8.61e-084533PF16423
DomainCOE1_DBD

EBF3 EBF1 EBF4

8.61e-084533PF16422
DomainCOE_HLH

EBF3 EBF1 EBF4

8.61e-084533IPR032201
DomainCOE_DBD

EBF3 EBF1 EBF4

8.61e-084533IPR032200
DomainCOE

EBF3 EBF1 EBF4

8.61e-084533PS01345
DomainTranscription_factor_COE_CS

EBF3 EBF1 EBF4

8.61e-084533IPR018350
DomainIPT

EBF3 EBF1 EBF4

6.01e-0527533SM00429
DomainTIG

EBF3 EBF1 EBF4

9.17e-0531533PF01833
DomainIPT

EBF3 EBF1 EBF4

1.01e-0432533IPR002909
DomainHomeobox_CS

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

1.81e-04186535IPR017970
DomainRetinoid-X_rcpt/HNF4

RXRB RXRG

3.50e-0410532IPR000003
Domain-

ASMT DOT1L METTL17 TRMT61A

3.72e-041205343.40.50.150
DomainSAM-dependent_MTases

ASMT DOT1L METTL17 TRMT61A

3.96e-04122534IPR029063
DomainHomeobox

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

5.20e-04234535PF00046
DomainHOMEOBOX_1

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

5.41e-04236535PS00027
DomainHOX

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

5.51e-04237535SM00389
Domain-

GATA6 RXRB RXRG

5.67e-04575333.30.50.10
DomainHomeobox_dom

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

5.72e-04239535IPR001356
DomainHOMEOBOX_2

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

5.72e-04239535PS50071
DomainZnf_NHR/GATA

GATA6 RXRB RXRG

5.96e-0458533IPR013088
Domain-

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

1.22e-032835351.10.10.60
DomainWnt

WNT3 WNT6

1.31e-0319532IPR005817
DomainWNT1

WNT3 WNT6

1.31e-0319532SM00097
DomainWnt_CS

WNT3 WNT6

1.31e-0319532IPR018161
Domainwnt

WNT3 WNT6

1.31e-0319532PF00110
DomainWNT1

WNT3 WNT6

1.31e-0319532PS00246
DomainHomeobox_metazoa

CDX2 HOXD8 EMX2

2.13e-0390533IPR020479
DomainHomeodomain-like

CDX2 HOXD8 HOXD13 ZFHX3 EMX2

2.46e-03332535IPR009057
DomainIg_E-set

EBF3 EBF1 EBF4

3.21e-03104533IPR014756
DomainHLH

EBF3 EBF1 EBF4

4.36e-03116533SM00353
Domainzf-C4

RXRB RXRG

7.55e-0346532PF00105
DomainNUCLEAR_REC_DBD_1

RXRB RXRG

7.55e-0346532PS00031
DomainZnf_hrmn_rcpt

RXRB RXRG

7.55e-0346532IPR001628
DomainNuclear_hrmn_rcpt

RXRB RXRG

7.55e-0346532IPR001723
DomainZnF_C4

RXRB RXRG

7.55e-0346532SM00399
DomainNUCLEAR_REC_DBD_2

RXRB RXRG

7.55e-0346532PS51030
Domain-

RXRB RXRG

7.87e-03475321.10.565.10
DomainHOLI

RXRB RXRG

8.20e-0348532SM00430
DomainNucl_hrmn_rcpt_lig-bd

RXRB RXRG

8.20e-0348532IPR000536
DomainHormone_recep

RXRB RXRG

8.20e-0348532PF00104
PathwayKEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY

SLC16A2 RXRB RXRG

7.24e-079303M47629
PathwayKEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION

RXRB RXRG

4.36e-055302M49023
PathwayWP_VITAMIN_A1_AND_A5X_PATHWAYS

RXRB RXRG

6.53e-056302M48097
PathwayREACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION

CDX2 GATA6

1.95e-0410302M27208
PathwayWP_CANCER_PATHWAYS

WNT3 WNT6 IL23A ADCY3 RXRB RXRG

5.97e-04507306M48302
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

HOXD8 EBF3 GATA6 ZFHX3 EBF1 ARID1A EMX2 RNF115 RXRB RXRG RNF111

8.19e-09709531122988430
Pubmed

A census of human transcription factors: function, expression and evolution.

CDX2 HOXD8 HOXD13 EBF3 GATA6 SP9 ZFHX3 EBF1 EMX2 RXRB RXRG EBF4

9.31e-09908531219274049
Pubmed

Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection.

EBF3 EBF1 EBF4

1.34e-08453312139918
Pubmed

Expression patterns of the coe/ebf transcription factor genes during chicken and mouse limb development.

EBF3 EBF1 EBF4

3.33e-08553315261831
Pubmed

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.

EBF3 SP9 ZFHX3 EBF1 EMX2 RXRG

4.83e-0813053619386638
Pubmed

Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.

EBF3 SP9 ZFHX3 EBF1 EMX2 RXRG

5.78e-0813453619030180
Pubmed

Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.

EBF3 EBF1 EBF4

1.16e-07753324786561
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

CDX2 HOXD8 HOXD13 ZIC5 GATA6 SP9 EMX2 RXRB RXRG

1.26e-0754453928473536
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

CDX2 WIZ ZIC5 EBF3 GATA6 ZFHX3 EBF1 ARID1A RXRB ZNF697

3.43e-07808531020412781
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

CDX2 HOXD13 EBF3 GATA6 EBF1 EMX2 ANKZF1 RXRB RXRG EBF4

7.22e-07877531020211142
Pubmed

Transient and lineage-restricted requirement of Ebf3 for sternum ossification.

EBF3 EBF1 EBF4

7.28e-071253332398354
Pubmed

An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.

EBF3 EBF1 EBF4

7.28e-071253330658714
Pubmed

Modular patterning of structure and function of the striatum by retinoid receptor signaling.

EBF1 RXRB RXRG

1.20e-061453318443282
Pubmed

External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium.

HOXD13 RXRB RXRG

1.85e-061653311795391
Pubmed

Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling.

EBF3 ZFHX3 EBF1

1.85e-061653317444492
Pubmed

Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development.

RXRB RXRG

2.28e-0625329150186
Pubmed

Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice.

RXRB RXRG

2.28e-06253220620876
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

EBF3 WNT6 EBF1 RXRB RXRG EBF4

2.30e-0625153629031500
Pubmed

Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.

CDX2 WNT3 GATA6

3.74e-062053323760955
Pubmed

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.

WNT3 WNT6 GATA6

4.36e-062153311914369
Pubmed

Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors.

EBF3 EBF1 EBF4

6.61e-062453320826655
Pubmed

Emx2 directs the development of diencephalon in cooperation with Otx2.

EBF3 EBF1 EMX2

6.61e-062453311493561
Pubmed

Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.

RXRB RXRG

6.83e-0635327831303
Pubmed

The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.

EBF3 EBF1

6.83e-0635329151732
Pubmed

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

RXRB RXRG

6.83e-0635321312497
Pubmed

Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.

RXRB RXRG

6.83e-0635327980510
Pubmed

Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.

RXRB RXRG

6.83e-06353212514092
Pubmed

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.

RXRB RXRG

6.83e-06353211053444
Pubmed

Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.

RXRB RXRG

6.83e-0635329452386
Pubmed

Retinoid X receptors: X-ploring their (patho)physiological functions.

RXRB RXRG

6.83e-06353215608692
Pubmed

Chromosomal localization of the human retinoid X receptors.

RXRB RXRG

6.83e-0635328034312
Pubmed

Retinoid receptors trigger neuritogenesis in retinal degenerations.

RXRB RXRG

6.83e-06353221940995
Pubmed

The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.

RXRB RXRG

6.83e-06353211839661
Pubmed

An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression.

RXRB RXRG

6.83e-0635329883728
Pubmed

GATA6 and FOXA2 regulate Wnt6 expression during extraembryonic endoderm formation.

WNT6 GATA6

6.83e-06353222607194
Pubmed

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

RXRB RXRG

6.83e-0635328799145
Pubmed

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.

WNT3 WNT6 ADCY3

1.07e-052853320940229
Pubmed

Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.

EBF3 SP9 EBF1

1.07e-052853330796806
Pubmed

EBF2 determines and maintains brown adipocyte identity.

EBF3 EBF1 EBF4

1.19e-052953323499423
Pubmed

Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.

SP9 ZFHX3 EBF1

1.19e-052953331491374
Pubmed

Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.

CDX2 GATA6

1.36e-05453225488664
Pubmed

Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.

RXRB RXRG

1.36e-0545321310259
Pubmed

Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.

RXRB RXRG

1.36e-05453210079186
Pubmed

Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.

RXRB RXRG

1.36e-05453226355550
Pubmed

Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.

EBF3 EBF1

1.36e-0545329151733
Pubmed

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes.

HOXD8 HOXD13

1.36e-05453229273679
Pubmed

Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.

RXRB RXRG

1.36e-05453219686701
Pubmed

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.

RXRB RXRG

1.36e-05453233692389
Pubmed

Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.

RXRB RXRG

1.36e-0545329804293
Pubmed

Salmonella regulation of intestinal stem cells through the Wnt/beta-catenin pathway.

WNT3 WNT6

1.36e-05453220083111
Pubmed

Regulated expression of Wnt family members during neuroectodermal differentiation of P19 embryonal carcinoma cells: overexpression of Wnt-1 perturbs normal differentiation-specific properties.

WNT3 WNT6

1.36e-0545327958454
Pubmed

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.

SP9 EBF1 RXRG

1.61e-053253335156680
Pubmed

Distinct roles and regulations for HoxD genes in metanephric kidney development.

HOXD8 HOXD13 GATA6

1.77e-053353318159948
Pubmed

Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.

WNT3 WNT6 EMX2

2.11e-053553332907846
Pubmed

Limb malformations and the human HOX genes.

HOXD8 HOXD13

2.27e-05553212357469
Pubmed

Developmental expression of murine retinoid X receptor (RXR) genes.

RXRB RXRG

2.27e-0555328199055
Pubmed

Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11.

EBF3 EBF1

2.27e-05553212917357
Pubmed

Retinoic acid signaling is necessary for the development of the organ of Corti.

RXRB RXRG

2.27e-05553210452855
Pubmed

GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation.

GDF15 ADCY3

2.27e-05553238719753
Pubmed

Stem cell niche-specific Ebf3 maintains the bone marrow cavity.

EBF3 EBF1

2.27e-05553229563184
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

WIZ HOXD13 ZIC5 EBF3 GATA6 ZFHX3 GTPBP1

2.84e-0558353729844126
Pubmed

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.

CDX2 HOXD13 RXRB RXRG

3.24e-0511853416971476
Pubmed

Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.

RXRB RXRG

3.40e-05653211328745
Pubmed

The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.

RXRB RXRG

3.40e-0565329153406
Pubmed

Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear.

RXRB RXRG

3.40e-0565329548551
Pubmed

Functional specificity of the two retinoic acid receptor RAR and RXR families in myogenesis.

RXRB RXRG

3.40e-0565329464546
Pubmed

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

RXRB RXRG

3.40e-05653220557428
Pubmed

RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells.

RXRB RXRG

3.40e-0565328801169
Pubmed

A decade of molecular biology of retinoic acid receptors.

RXRB RXRG

3.40e-0565328801176
Pubmed

Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma.

RXRB RXRG

3.40e-05653222205725
Pubmed

The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.

RXRB RXRG

3.40e-0565329806918
Pubmed

The constrained architecture of mammalian Hox gene clusters.

HOXD8 HOXD13

3.40e-05653231209053
Pubmed

TGIF inhibits retinoid signaling.

RXRB RXRG

3.40e-05653216428452
Pubmed

Progression of the pluripotent epiblast depends upon the NMD factor UPF2.

CDX2 GATA6

3.40e-05653236255229
Pubmed

A genetic dissection of the retinoid signalling pathway in the mouse.

RXRB RXRG

3.40e-05653210604193
Pubmed

Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.

RXRB RXRG

3.40e-0565327947324
Pubmed

The primitive endoderm supports lineage plasticity to enable regulative development.

CDX2 GATA6

3.40e-05653238917790
Pubmed

The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway.

EBF3 EBF1

3.40e-05653220621716
Pubmed

Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.

RXRB RXRG

3.40e-0565329075714
Pubmed

Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.

EBF3 EBF1

3.40e-0565329389446
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

CDX2 WNT3 WNT6 GATA6 ZFHX3 RXRB

4.48e-0542453621731673
Pubmed

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.

RXRB RXRG

4.76e-0575329428411
Pubmed

The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.

CDX2 GATA6

4.76e-05753228289135
Pubmed

Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo.

CDX2 GATA6

4.76e-05753220479880
Pubmed

FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst.

CDX2 GATA6

4.76e-05753224063807
Pubmed

Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha.

RXRB RXRG

4.76e-05753211493527
Pubmed

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes.

HOXD8 HOXD13

4.76e-05753231299961
Pubmed

Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions.

RXRB RXRG

4.76e-05753212360493
Pubmed

Early developmental plasticity enables the induction of an intermediate extraembryonic cell state.

CDX2 GATA6

4.76e-05753236332016
Pubmed

Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors.

RXRB RXRG

4.76e-05753217195188
Pubmed

The structure of the nuclear hormone receptors.

RXRB RXRG

4.76e-05753210406480
Pubmed

Analysis of the factors involved in the retinoic acid-induced differentiation of a retinoid-hypersensitive embryonal carcinoma cell mutant.

RXRB RXRG

4.76e-0575328299717
Pubmed

Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases.

RXRB RXRG

4.76e-05753215635645
Pubmed

Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF.

CDX2 GATA6

4.76e-05753236260992
Pubmed

Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.

RXRB RXRG

4.76e-0575328090775
Pubmed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.

CDX2 HOXD8 HOXD13

6.23e-055053328188179
Pubmed

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.

CDX2 GATA6

6.34e-05853226199412
Pubmed

GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function.

HCN4 GATA6

6.34e-05853225613430
Pubmed

Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression.

RXRB RXRG

6.34e-05853210490294
Pubmed

Expression of nuclear retinoic acid receptors during mouse odontogenesis.

RXRB RXRG

6.34e-0585327988794
InteractionEBF4 interactions

EBF3 EBF1 EBF4

5.97e-077533int:EBF4
Cytoband2q31.1

HOXD8 HOXD13 SP9

1.30e-04845332q31.1
CytobandEnsembl 112 genes in cytogenetic band chr2q31

HOXD8 HOXD13 SP9

1.16e-03178533chr2q31
GeneFamilyHOXL subclass homeoboxes

CDX2 HOXD8 HOXD13

1.38e-0452353518
GeneFamilyWnt family|Endogenous ligands

WNT3 WNT6

6.10e-0419352360
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

WIZ ZIC5 SP9 ZFHX3 ANKZF1 ZNF697

2.33e-0371835628
GeneFamilyNuclear hormone receptors

RXRB RXRG

4.04e-034935271
CoexpressionBENPORATH_SUZ12_TARGETS

CDX2 HOXD8 HCN4 HOXD13 EBF3 WNT3 WNT6 GATA6 ZFHX3 EMX2 RXRG

5.74e-0610355311M9898
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500

CDX2 HOXD8 EBF3 WNT3 WNT6 GATA6 ZFHX3 EBF1 RXRG

3.54e-06498539PCBC_ratio_EB_vs_SC_500
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_1000

CDX2 HOXD8 EBF3 WNT3 WNT6 GATA6 ZFHX3 EBF1 EMX2 RXRG EBF4

2.80e-059945311PCBC_ratio_EB_vs_SC_1000
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HCN4 EBF1 METTL17 RXRG ZNF697

8.50e-071465352ac9b487a7991fdc15444aeb93533030e09825bb
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ASMT SBF2 MYOM2 CENATAC EBF4

9.09e-07148535e7bbb5ddf44b11b8495e83863fbf1fd9f3f24472
ToppCellThalamus|World / BrainAtlas - Mouse McCarroll V32

HCN4 ZIC5 WNT3 ZFHX3

1.11e-051165345ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell|368C / Donor, Lineage, Cell class and subclass (all cells)

ASMT SBF2 MYOM2 CENATAC

3.14e-05151534512f7f37ddc8dfa1906f7fff92b571929236c9ea
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

4.13e-05162534c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

4.13e-05162534f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

4.13e-051625345d902bb31e691aea9749617cc88303c2448f24b8
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EBF1 GLOD4 ADCY3 DYRK2

4.13e-0516253482e782096f89cd03d1fdf599ba727d6f23e35e2d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EBF1 GLOD4 ADCY3 DYRK2

4.13e-051625346bed33b17b59812646dc6a29c1d87413bad86c11
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EBF1 GLOD4 ADCY3 DYRK2

4.13e-05162534502ed67f6a572f10ac6e22948a1747d8214eb974
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 EBF1 ADCY3 RXRG

4.34e-0516453443630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 EBF1 ADCY3 RXRG

4.34e-05164534108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 EBF1 ADCY3 RXRG

4.34e-0516453446208f18325976c89f572f6627aea0582142b92d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

4.99e-0517053499dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

4.99e-051705343a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

4.99e-05170534cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellP15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HOXD8 ZIC5 EBF3 TMEM200C

5.58e-0517553484d252f3e432231687613299bbea14978bb4b06b
ToppCellP15-Endothelial-lymphatic_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HOXD8 ZIC5 EBF3 TMEM200C

5.58e-05175534a00c6fa9b33640710dd05a3799031147196f0986
ToppCellCOVID-19-kidney-vSMC/Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZFHX3 MYOM2 EBF1 ADCY3

6.09e-05179534111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

EBF3 WNT6 EBF1 ADCY3

6.50e-05182534e67f3234165199085c793915ebb1f9bbd845e933
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WNT6 TMEM200C RXRG TRMT61A

6.50e-05182534a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCellP03-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

WNT3 WNT6 TMEM200C RXRG

6.78e-051845348880ff36c243cc60a524d74934d000aef26a70ac
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GDF15 ZFHX3 DOT1L CENATAC

6.92e-0518553438486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GDF15 ZFHX3 DOT1L CENATAC

6.92e-051855343c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EBF3 WNT6 EBF1 TMEM200C

7.22e-05187534b8f88599e22b9b345c7ec3bbecd87a8b2a033f9f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN2 EBF3 HPGD EBF1

7.37e-05188534ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

7.52e-051895347fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIDN WNT3 WNT6 DOT1L

7.52e-051895341cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCellfacs-Skin-nan-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIDN WNT3 WNT6 ASMT

7.52e-051895346c71e81373cb7822de23c193a6350b6df9f567bc
ToppCellP03-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GDF15 ZFHX3 EBF1 ADCY3

7.52e-05189534b5439ef221106f6d54434f268485e9bb17b39102
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

7.52e-0518953406b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIDN WNT3 WNT6 DOT1L

7.68e-051905343639eb9b887a2d76949cad4a2586524fe0e1015f
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D175|Adult / Lineage, Cell type, age group and donor

SLC16A2 EBF3 EBF1 ADCY3

7.68e-051905347dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN2 EBF3 HPGD EBF1

7.68e-05190534efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellCOVID-19-kidney-vSMC/Pericyte|kidney / Disease (COVID-19 only), tissue and cell type

ZFHX3 MYOM2 EBF1 ADCY3

7.83e-05191534fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

7.99e-05192534b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 MYOM2 EBF1 ADCY3

7.99e-05192534bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HCN4 WNT6 CYB561D2 EMX2

8.65e-0519653495544097577f20ed7f4144bd940471cde0617554
ToppCellmLN-T_cell-Th17|mLN / Region, Cell class and subclass

PNPLA1 SLC16A2 HPGD IL23A

9.00e-0519853404905f62941b193864704a10ad692faf777fa51d
ToppCellCOVID-19-kidney-Fibroblast-2|kidney / Disease (COVID-19 only), tissue and cell type

EBF3 GATA6 EBF1 ADCY3

9.00e-05198534ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCellmLN-(1)_T_cell-(13)_Th17|mLN / shred on region, Cell_type, and subtype

PNPLA1 SLC16A2 HPGD IL23A

9.00e-05198534c575e9aeee4e034e8c4d171fe754403652343731
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm|5w / Sample Type, Dataset, Time_group, and Cell type.

GDF15 CYB561D2 ANKZF1 IL23A

9.36e-052005340927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCellTracheal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

WNT6 EBF1 EMX2 ADCY3

9.36e-052005349d3ae9ea47b1017adb63aa02d10e98193d478458
ToppCellTracheal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

WNT6 EBF1 EMX2 ADCY3

9.36e-0520053478cd0b7d221ef855512ee9ac9a291f61622c2e24
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EBF3 EBF1 EMX2

1.47e-04865332990429ed4438f41ff03f4a9cae8863a528fdd81
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-CR|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EBF3 EBF1 EMX2

1.47e-048653397467708c90a4bd49deafe3e2ec495c56b448ce1
DrugAC1L9M5J

WNT3 WNT6 GATA6 CLN6 ZFHX3 RXRB RXRG

7.79e-07221537CID000448615
DrugBexarotene

RXRB RXRG

1.59e-053532DB00307
Drug2-hydroxyphytanic acid

RXRB RXRG

1.59e-053532ctd:C002585
DrugAC1O5SBP

RXRB RXRG

1.59e-053532CID006439746
DiseaseKlatskin's tumor (is_implicated_in)

GATA6 ARID1A

2.80e-055502DOID:4927 (is_implicated_in)
DiseaseBarrett's esophagus (is_marker_for)

CDX2 GATA6

1.53e-0411502DOID:9206 (is_marker_for)
Diseaseesophagus adenocarcinoma (is_marker_for)

ARID1A EMX2

1.84e-0412502DOID:4914 (is_marker_for)
Diseaseelectrocardiography

HMCN2 HCN4 GATA6 EBF1 RXRG PSMG4

2.65e-04530506EFO_0004327
Diseaseanterior thigh muscle fat infiltration measurement

HMCN2 EBF1

1.03e-0328502EFO_0020936
Diseasehematocrit

MIDN PNPLA1 WNT3 SBF2 EBF1 DOT1L EMX2

1.50e-031011507EFO_0004348
Diseaseposterior thigh muscle fat infiltration measurement

HMCN2 EBF1

1.62e-0335502EFO_0020934

Protein segments in the cluster

PeptideGeneStartEntry
GGYHVAAAAAAAANL

CDX2

41

Q99626
AAAAAARLHGGFDSD

GTPBP1

31

O00178
VAAVAAGVRASAHGT

ASMT

46

P46597
AGGAASSAQTHRSFL

DOT1L

1451

Q8TEK3
DSGSDHLAFVRAVAG

DHX30

931

Q7L2E3
AGAAVAFIGLHTSSF

SLC16A2

176

P36021
RSPSAVAAAAAAVFH

ARID1A

156

O14497
FAPEVGGRHAAAAAA

HOXD8

36

P13378
VGARLAGKDHSASFS

SBF2

1286

Q86WG5
GGVDHAAAFGRIAFS

GLOD4

206

Q9HC38
GSVHFAAIRTSDAGR

HMCN2

1211

Q8NDA2
AHRFAGTSAGAVIAA

PNPLA1

46

Q8N8W4
HGGALSLAEASRASF

GDF15

26

Q99988
SAGVAATTIAGFGHF

HCN4

896

Q9Y3Q4
GHARDAFSFGTLVES

SCYL3

186

Q8IZE3
TIARVHGTFGAAACS

POP5

36

Q969H6
PGGFVHSAAAAAAAA

GATA6

166

Q92908
FTLLHAAAAAGRGSV

ANKZF1

536

Q9H8Y5
STAAQSGVGLARAHF

EBF4

41

Q9BQW3
AFVAVAARVFAHGAA

IL23A

171

Q9NPF7
APVFAGTHSGRAAAA

HOXD13

46

P35453
GTHSGRAAAAAAAAA

HOXD13

51

P35453
GLNFARAHAASDTVG

ADCY3

156

O60266
TAAQSGVGLARAHFE

EBF1

41

Q9UH73
RVGANFDHSSRTSAG

CENATAC

281

Q86UT8
FHSAAAAAAGRGVYS

EMX2

51

Q04743
ARSAGFHPSGSVLAV

EML2

421

O95834
GIGLFALAHAAFSAA

MMGT1

11

Q8N4V1
TAAQSGVGLARAHFE

EBF3

41

Q9H4W6
RASNAAAAAHTIGGS

DYRK2

56

Q92630
ARLDGGFAAVSRAFH

METTL17

161

Q9H7H0
RTASGAAAHLVALGF

CYB561D2

16

O14569
HGIVGFTRSAALAAN

HPGD

156

P15428
RHVLAAAAAAAAARG

MIDN

166

Q504T8
AAGADSGAAVAAHRF

RNF115

6

Q9Y4L5
GVAGSRRAAAATAAA

TMEM200C

331

A6NKL6
HGFIASVAAVARADG

SLC25A34

51

Q6PIV7
AGFDTRAGLSSHARA

WIZ

776

O95785
VAAGGDVSLHNFSAR

PSMG4

6

Q5JS54
HDSGVSAARAAAAAA

SP9

446

P0CG40
NSAHSAGVGAIFDRV

RXRB

406

P28702
AFHPGLAAAASARAS

GOT2

16

P00505
GASFLQARHGSVSAD

CLN6

21

Q9NWW5
RAAILSVAGSAGSSH

nan

101

P0C880
SSRAAIFGHQAAAAA

RNF111

596

Q6ZNA4
RSGFGVSHVADAVFL

TRMT61A

166

Q96FX7
SARHVVFSGSGRAAG

RPP25L

51

Q8N5L8
HAIASAGVAFAVTRS

WNT3

116

P56703
AFVFAITAAGASHAV

WNT6

106

Q9Y6F9
SSAHSAGVGSIFDRV

RXRG

336

P48443
RRAHAAASGAGAAAL

ZNF697

336

Q5TEC3
FSHTAGAAAAAVAAA

ZFHX3

766

Q15911
VAAAAAAALHGYGAV

ZIC5

316

Q96T25
GFSSHQAVARTAGSV

NAALADL1

561

Q9UQQ1
GGVSDHSAFLFVRDA

MYOM2

361

P54296