Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRIM33 IRF2BP1 TRIM4 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	3.50e-05	473	69	9	GO:0004842
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activator activity	IGF1 IGF2 NGF	5.80e-05	22	69	3	GO:0030297
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRIM33 IRF2BP1 TRIM4 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	6.45e-05	512	69	9	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRIM33 IRF2BP1 TRIM4 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	8.65e-05	532	69	9	GO:0016755
GeneOntologyMolecularFunction	protein tyrosine kinase activator activity	IGF1 IGF2 NGF	2.60e-04	36	69	3	GO:0030296
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM33 IRF2BP1 TRIM4 TRIM40 MDM2 TRIM14 SH3RF3	2.94e-04	372	69	7	GO:0061630
GeneOntologyMolecularFunction	acyltransferase activity	TRIM33 IRF2BP1 TRIM4 GPAT3 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	3.13e-04	775	69	10	GO:0016746
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM33 IRF2BP1 TRIM4 TRIM40 MDM2 TRIM14 SH3RF3	4.42e-04	398	69	7	GO:0061659
GeneOntologyMolecularFunction	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	ENDOV DICER1	1.04e-03	14	69	2	GO:0016888
GeneOntologyMolecularFunction	DNA nuclease activity	POLE ENDOV DICER1	1.61e-03	67	69	3	GO:0004536
GeneOntologyMolecularFunction	insulin-like growth factor receptor binding	IGF1 IGF2	1.74e-03	18	69	2	GO:0005159
GeneOntologyMolecularFunction	protein kinase activator activity	IGF1 IGF2 NGF GPRC5D	1.77e-03	149	69	4	GO:0030295
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	TRIM33 AHRR DET1 IRF2BP1 MEGF8 TRIM4 NGF SAE1 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	1.23e-06	893	69	14	GO:0032446
GeneOntologyBiologicalProcess	protein ubiquitination	TRIM33 DET1 IRF2BP1 MEGF8 TRIM4 NGF SAE1 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	2.46e-06	811	69	13	GO:0016567
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	TRIM33 AHRR DET1 IRF2BP1 MEGF8 TRIM4 NGF SAE1 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	5.12e-06	1009	69	14	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	TRIM33 AHRR DET1 IRF2BP1 MEGF8 TRIM4 NGF SAE1 FBXO11 TRIM40 MDM2 TRIM14 SH3RF3 RBCK1	1.04e-05	1074	69	14	GO:0043687
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	2.10e-07	4	71	3	PF14914
Domain	LRRC37_N	LRRC37A LRRC37A3 LRRC37A2	2.10e-07	4	71	3	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	2.10e-07	4	71	3	IPR029423
Domain	LRRC37	LRRC37A LRRC37A3 LRRC37A2	2.10e-07	4	71	3	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A3 LRRC37A2	2.10e-07	4	71	3	IPR015753
Domain	ZF_BBOX	TRIM33 TRIM4 TRIM40 TRIM14 RBCK1	1.33e-05	80	71	5	PS50119
Domain	Znf_B-box	TRIM33 TRIM4 TRIM40 TRIM14 RBCK1	1.41e-05	81	71	5	IPR000315
Domain	Insulin-like_growth_factor	IGF1 IGF2	1.42e-05	2	71	2	IPR022350
Domain	-	TRIM33 TRIM4 TRIM40 TRIM14	1.54e-04	71	71	4	4.10.45.10
Domain	Insulin_family	IGF1 IGF2	2.12e-04	6	71	2	IPR022352
Domain	-	TRIM33 RBSN TRIM4 MLLT10 TRIM40 MDM2 SH3RF3 RBCK1	2.96e-04	449	71	8	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TRIM33 RBSN TRIM4 MLLT10 TRIM40 MDM2 SH3RF3 RBCK1	3.43e-04	459	71	8	IPR013083
Domain	Znf_RING_CS	TRIM33 TRIM4 TRIM40 SH3RF3 RBCK1	3.90e-04	163	71	5	IPR017907
Domain	Insulin_CS	IGF1 IGF2	5.04e-04	9	71	2	IPR022353
Domain	-	IGF1 IGF2	5.04e-04	9	71	2	1.10.100.10
Domain	Insulin	IGF1 IGF2	6.29e-04	10	71	2	PF00049
Domain	INSULIN	IGF1 IGF2	6.29e-04	10	71	2	PS00262
Domain	Insulin	IGF1 IGF2	7.66e-04	11	71	2	IPR004825
Domain	Insulin-like	IGF1 IGF2	7.66e-04	11	71	2	IPR016179
Domain	IlGF	IGF1 IGF2	7.66e-04	11	71	2	SM00078
Domain	ZF_RING_1	TRIM33 TRIM4 TRIM40 MDM2 SH3RF3 RBCK1	8.33e-04	291	71	6	PS00518
Domain	ZF_RING_2	TRIM33 TRIM4 TRIM40 MDM2 SH3RF3 RBCK1	9.42e-04	298	71	6	PS50089
Domain	RING	TRIM33 TRIM4 TRIM40 MDM2 SH3RF3 RBCK1	1.06e-03	305	71	6	SM00184
Domain	Znf_RING	TRIM33 TRIM4 TRIM40 MDM2 SH3RF3 RBCK1	1.49e-03	326	71	6	IPR001841
Domain	BBOX	TRIM33 TRIM4 TRIM14	2.30e-03	69	71	3	SM00336
Domain	zf-B_box	TRIM33 TRIM4 TRIM14	2.60e-03	72	71	3	PF00643
Domain	zf-RanBP	MDM2 RBCK1	3.13e-03	22	71	2	PF00641
Domain	ZF_RANBP2_2	MDM2 RBCK1	3.42e-03	23	71	2	PS50199
Domain	ARM-like	PDS5A NBEA HEATR5A ATXN10 TNPO3	3.64e-03	270	71	5	IPR011989
Domain	ZF_RANBP2_1	MDM2 RBCK1	3.73e-03	24	71	2	PS01358
Domain	PAS	AHRR AHR	4.04e-03	25	71	2	PF00989
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	3.40e-08	4	72	3	22419166
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A3 LRRC37A2	1.01e-06	10	72	3	23064749
Pubmed	Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice.	IGF1 IGF2	4.23e-06	2	72	2	21802327
Pubmed	Genome-wide mapping and analysis of aryl hydrocarbon receptor (AHR)- and aryl hydrocarbon receptor repressor (AHRR)-binding sites in human breast cancer cells.	AHRR AHR	4.23e-06	2	72	2	28681081
Pubmed	Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size.	IGF1 IGF2	4.23e-06	2	72	2	15217931
Pubmed	Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours.	IGF1 IGF2	4.23e-06	2	72	2	32161368
Pubmed	Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.	IGF1 IGF2	4.23e-06	2	72	2	6189745
Pubmed	Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators.	IGF1 IGF2	4.23e-06	2	72	2	23497056
Pubmed	IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats.	IGF1 IGF2	4.23e-06	2	72	2	12388463
Pubmed	Insulin like growth factor 2 regulation of aryl hydrocarbon receptor in MCF-7 breast cancer cells.	IGF2 AHR	4.23e-06	2	72	2	24380854
Pubmed	The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months.	IGF1 IGF2	4.23e-06	2	72	2	30745570
Pubmed	Association of IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with COPD: A cross-sectional study.	IGF1 IGF2	4.23e-06	2	72	2	38687996
Pubmed	Both type I and II insulin-like growth factor receptor binding increase during lactogenesis in bovine mammary tissue.	IGF1 IGF2	4.23e-06	2	72	2	2967174
Pubmed	Organization of the human genes for insulin-like growth factors I and II.	IGF1 IGF2	4.23e-06	2	72	2	3002851
Pubmed	Biological actions of IGFs in mammalian development.	IGF1 IGF2	4.23e-06	2	72	2	8141806
Pubmed	IGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study.	IGF1 IGF2	4.23e-06	2	72	2	18199734
Pubmed	Beta cell expression of IGF-I leads to recovery from type 1 diabetes.	IGF1 IGF2	4.23e-06	2	72	2	11994404
Pubmed	Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.	IGF1 IGF2	4.23e-06	2	72	2	15528386
Pubmed	Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer.	IGF1 IGF2	4.23e-06	2	72	2	19064563
Pubmed	Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling.	AHRR AHR	4.23e-06	2	72	2	15758562
Pubmed	Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.	IGF1 IGF2	4.23e-06	2	72	2	17008389
Pubmed	Insulin-like growth factors induce apoptosis as well as proliferation in LIM 1215 colon cancer cells.	IGF1 IGF2	4.23e-06	2	72	2	16888814
Pubmed	IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review.	IGF1 IGF2	4.23e-06	2	72	2	38612776
Pubmed	Insulin-like growth factors promote vasculogenesis in embryonic stem cells.	IGF1 IGF2	4.23e-06	2	72	2	22363814
Pubmed	Longitudinal data for intrauterine levels of fetal IGF-I and IGF-II.	IGF1 IGF2	4.23e-06	2	72	2	14764950
Pubmed	Genetic factors and insulin secretion: gene variants in the IGF genes.	IGF1 IGF2	4.23e-06	2	72	2	14749262
Pubmed	Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk.	IGF1 IGF2	4.23e-06	2	72	2	19417744
Pubmed	Insulin-like growth factor II promotes in vitro cholinergic development of mouse septal neurons: comparison with the effects of insulin-like growth factor I.	IGF1 IGF2	4.23e-06	2	72	2	7953654
Pubmed	Detection of insulin and insulin-like growth factors I and II in saliva and potential synthesis in the salivary glands of mice. Effects of type 1 diabetes mellitus.	IGF1 IGF2	4.23e-06	2	72	2	7763295
Pubmed	Modeling the Insulin-Like Growth Factor System in Articular Cartilage.	IGF1 IGF2	4.23e-06	2	72	2	23840540
Pubmed	Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.	AHRR AHR	4.23e-06	2	72	2	27184933
Pubmed	IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage.	IGF1 IGF2	4.23e-06	2	72	2	20206398
Pubmed	Functions of the IGFs in early mammalian development.	IGF1 IGF2	4.23e-06	2	72	2	8398122
Pubmed	Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression.	IGF1 IGF2	4.23e-06	2	72	2	3683205
Pubmed	Expression of insulin-like growth factors I and II in conceptuses from normal and diabetic mice.	IGF1 IGF2	4.23e-06	2	72	2	8011322
Pubmed	Insulin family growth factors have specific effects on protein synthesis in preimplantation mouse embryos.	IGF1 IGF2	4.23e-06	2	72	2	8011324
Pubmed	Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins.	AHRR AHR	4.23e-06	2	72	2	15474075
Pubmed	In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice.	IGF1 MDM2	4.23e-06	2	72	2	7472488
Pubmed	Insulin-like growth factor (IGF) 1 and 2 help to predict disease outcome in GIST patients.	IGF1 IGF2	4.23e-06	2	72	2	18372285
Pubmed	Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells.	IGF1 IGF2	4.23e-06	2	72	2	23054195
Pubmed	Insulin-like growth factor II precursor gene organization in relation to insulin gene family.	IGF1 IGF2	4.23e-06	2	72	2	6382022
Pubmed	In vitro re-expression of the aryl hydrocarbon receptor (Ahr) in cultured Ahr-deficient mouse antral follicles partially restores the phenotype to that of cultured wild-type mouse follicles.	AHRR AHR	4.23e-06	2	72	2	25500125
Pubmed	The role of insulin-like growth factors in small intestinal cell growth and development.	IGF1 IGF2	4.23e-06	2	72	2	10226789
Pubmed	Transcriptional regulation and biological significance of the insulin like growth factor II gene.	IGF1 IGF2	4.23e-06	2	72	2	9925986
Pubmed	Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2.	AHRR AHR	4.23e-06	2	72	2	11742002
Pubmed	Cognitive and social functions and growth factors in a mouse model of Rett syndrome.	IGF1 NGF	1.27e-05	3	72	2	20045424
Pubmed	Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type).	IGF1 IGF2	1.27e-05	3	72	2	17560154
Pubmed	Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling.	IGF1 IGF2	1.27e-05	3	72	2	22982059
Pubmed	Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality: findings from a nested case-control study within the Japan Collaborative Cohort Study.	IGF1 IGF2	1.27e-05	3	72	2	20427254
Pubmed	Possible autocrine/paracrine actions of insulin-like growth factors during embryonic development: expression and action of IGFs in undifferentiated P19 cells.	IGF1 IGF2	1.27e-05	3	72	2	8358865
Pubmed	Association between endometriosis and polymorphisms in insulin-like growth factors (IGFs) and IGF-I receptor genes in Korean women.	IGF1 IGF2	1.27e-05	3	72	2	21251749
Pubmed	Insulin-like growth factors-I and -II and their binding proteins during postnatal development of dwarf Snell mice before and during growth hormone and thyroxine therapy.	IGF1 IGF2	1.27e-05	3	72	2	7525829
Pubmed	MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.	MDM2 NDUFS1	1.27e-05	3	72	2	30879903
Pubmed	Differential effects of low birthweight and intrauterine growth restriction on umbilical cord blood insulin-like growth factor concentrations.	IGF1 IGF2	1.27e-05	3	72	2	26118397
Pubmed	Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis.	AHRR AHR	1.27e-05	3	72	2	11835227
Pubmed	The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice.	IGF1 IGF2	1.27e-05	3	72	2	16890611
Pubmed	Insulin-like growth factor 2 enhances insulinogenic differentiation of human eyelid adipose stem cells via the insulin receptor.	IGF1 IGF2	1.27e-05	3	72	2	21535266
Pubmed	Selective response to insulin versus insulin-like growth factor-I and -II and up-regulation of insulin receptor splice variant B in the differentiated mouse mammary epithelium.	IGF1 IGF2	1.27e-05	3	72	2	19246539
Pubmed	bFGF enhances the IGFs-mediated pluripotent and differentiation potentials in multipotent stem cells.	IGF1 IGF2	1.27e-05	3	72	2	19919531
Pubmed	Ligand-specific antibodies to insulin-like growth factors suppress intestinal polyp formation in Apc+/- mice.	IGF1 IGF2	1.27e-05	3	72	2	20103605
Pubmed	The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents.	IGF1 IGF2	1.27e-05	3	72	2	22245250
Pubmed	PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma.	IGF1 IGF2	1.27e-05	3	72	2	26336825
Pubmed	The pregnancy-associated plasma protein A and insulin-like growth factor system in response to cigarette smoking.	IGF1 IGF2	1.27e-05	3	72	2	22630333
Pubmed	The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer.	IGF1 IGF2	1.27e-05	3	72	2	16935391
Pubmed	Response of IGF and IL-6 to ovarian stimulation in PCOS and normal women.	IGF1 IGF2	1.27e-05	3	72	2	19938957
Pubmed	Effects and differentiation activity of IGF-I, IGF-II, insulin and preptin on human primary bone cells.	IGF1 IGF2	1.27e-05	3	72	2	23410103
Pubmed	IGF-I and IGF-II stimulate directed cell migration of bone-marrow-derived human mesenchymal progenitor cells.	IGF1 IGF2	1.27e-05	3	72	2	16716263
Pubmed	Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling.	AHRR AHR	1.27e-05	3	72	2	24806346
Pubmed	Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism.	IGF1 IGF2	1.27e-05	3	72	2	16115888
Pubmed	Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III.	IGF1 IGF2	1.27e-05	3	72	2	1733942
Pubmed	Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).	IGF1 IGF2	1.27e-05	3	72	2	8402901
Pubmed	MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon.	POLE MDM2	1.27e-05	3	72	2	10982879
Pubmed	Expression of insulin-like growth factors in the placenta in preeclampsia.	IGF1 IGF2	1.27e-05	3	72	2	24915949
Pubmed	Prognostic Significance of IGF-1 Signalling Pathway in Patients With Advanced Non-small Cell Lung Cancer.	IGF1 IGF2	1.27e-05	3	72	2	31366504
Pubmed	Does insulin-like growth factor 1 receptor (IGF-1R) targeting provide new treatment options for chordomas? A retrospective clinical and immunohistochemical study.	IGF1 IGF2	1.27e-05	3	72	2	22372631
Pubmed	Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction.	IGF1 IGF2	1.27e-05	3	72	2	21823995
Pubmed	Genetic polymorphisms in the aryl hydrocarbon receptor-signaling pathway and sleep disturbances in middle-aged women.	AHRR AHR	1.27e-05	3	72	2	23768840
Pubmed	Insulin-like growth factors.	IGF1 IGF2	1.27e-05	3	72	2	7640658
Pubmed	Peptide concentrations and mRNA expression of IGF-I, IGF-II and IGFBP-3 in breast cancer and their associations with disease characteristics.	IGF1 IGF2	1.27e-05	3	72	2	18481170
Pubmed	Multidisciplinary team collaboration impact on NGF, BDNF, serum IGF-1, and life quality in patients with hemiplegia after stroke.	IGF1 NGF	1.27e-05	3	72	2	38063117
Pubmed	Elevated serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder.	IGF1 NGF	1.27e-05	3	72	2	24793757
Pubmed	Structure-function analysis of the human insulin-like growth factor binding protein-4.	IGF1 IGF2	1.27e-05	3	72	2	9722589
Pubmed	Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis.	IGF2 PLCB2	1.27e-05	3	72	2	18832656
Pubmed	Interaction of insulin-like growth factor (IGF)-I and -II with IGF binding protein-2: mapping the binding surfaces by nuclear magnetic resonance.	IGF1 IGF2	1.27e-05	3	72	2	15956340
Pubmed	Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells.	IGF1 IGF2	1.27e-05	3	72	2	15694994
Pubmed	A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.	IGF1 IGF2	1.27e-05	3	72	2	22253814
Pubmed	Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk.	IGF1 IGF2	1.27e-05	3	72	2	22347413
Pubmed	Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells.	IGF1 IGF2	1.27e-05	3	72	2	15809062
Pubmed	Modifying effect of the AR gene trinucleotide repeats and SNPs in the AHR and AHRR genes on the association between persistent organohalogen pollutant exposure and human sperm Y:X ratio.	AHRR AHR	1.27e-05	3	72	2	17244640
Pubmed	Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation.	IGF1 IGF2	1.27e-05	3	72	2	34097060
Pubmed	Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice.	IGF1 IGF2	1.27e-05	3	72	2	39283743
Pubmed	Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients.	IGF1 IGF2	1.27e-05	3	72	2	15954927
Pubmed	Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3.	IGF1 IGF2	1.27e-05	3	72	2	19786462
Pubmed	Control of brain development and homeostasis by local and systemic insulin signalling.	IGF1 IGF2	1.27e-05	3	72	2	25200291
Pubmed	Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding.	IGF1 IGF2	1.27e-05	3	72	2	11600567
Pubmed	Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells.	IGF1 IGF2	1.27e-05	3	72	2	18520331
Pubmed	The production and regulation of IGF and IGFBPs in human adipose tissue cultures.	IGF1 IGF2	1.27e-05	3	72	2	23079385
Pubmed	Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage.	IGF1 MDM2	1.27e-05	3	72	2	11877395
Pubmed	Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment.	IGF1 IGF2	1.27e-05	3	72	2	14710345
Pubmed	Identification of a novel mechanism of regulation of Ah (dioxin) receptor function.	AHRR AHR	1.27e-05	3	72	2	9887096
Cytoband	1p32	RLF ORC1	8.30e-04	27	72	2	1p32
Cytoband	1p13.1	TRIM33 NGF	1.24e-03	33	72	2	1p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p25	RBSN IRAK2 IL17RC	1.90e-03	155	72	3	chr3p25
Cytoband	3p25.3	IRAK2 IL17RC	2.30e-03	45	72	2	3p25.3
Cytoband	16q21	ZNF319 CNOT1	2.30e-03	45	72	2	16q21
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM33 TRIM4 TRIM40 TRIM14	1.48e-04	95	51	4	59
GeneFamily	Ring finger proteins	TRIM33 TRIM4 TRIM40 SH3RF3 RBCK1	1.04e-03	275	51	5	58
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	MDM2 RBCK1	1.58e-03	21	51	2	89
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SHISA9 IGF1 PTPRZ1 NGF NBEA	6.36e-06	161	72	5	3b5d7a3dab479c6959a428f3954dedd989900276
ToppCell	RA-16._Neuronal\|World / Chamber and Cluster_Paper	SHISA9 PTPRZ1 AHR HS3ST2 SH3RF3	1.12e-05	181	72	5	7d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	AHRR GPR157 GPAT3 IRAK2 MCOLN2	1.28e-05	186	72	5	0dce13e15c3bf32610bf2dad31253b52a39cff87
ToppCell	normal_Lung-Myeloid_cells-CD141+_DCs\|normal_Lung / Location, Cell class and cell subclass	GPR157 GPAT3 IRAK2 BTLA MCOLN2	1.28e-05	186	72	5	a6698a2f4edd81b67e06531ede0e207dd0309205
ToppCell	(3)_DC_1\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	GPR157 GPAT3 IRAK2 BTLA MCOLN2	1.35e-05	188	72	5	ee616d14e060385ee55e4cd5b60218e9374c6065
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	TRIM33 TRAPPC10 PDS5A HEATR5A NDUFS1	1.53e-05	193	72	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MANBA GPR157 GPAT3 IRAK2 MCOLN2	1.57e-05	194	72	5	bde6830a281f7cd7fd1733e40a41ddd2673ba88e
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_activated\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GPR157 IRAK2 BTLA MCOLN2	4.89e-05	124	72	4	e16be7805c91db12b1110c90cd39492913f1d3ea
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GPR157 GPAT3 IRAK2 MCOLN2	6.61e-05	134	72	4	0b1bb6fee8a2d8c27bca6d9cac6b47e85073dbf7
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SHISA9 IGF1 PTPRZ1 NGF	9.72e-05	148	72	4	5e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SHISA9 IGF1 PTPRZ1 NGF	1.08e-04	152	72	4	8ff5a178a8f3550d89a003c0858820aab3773386
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PLCB2 DDX60L MLLT10 HS3ST2	1.31e-04	160	72	4	636127753e3a22831f39d4c8170df40901e4329d
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PLCB2 DDX60L MLLT10 HS3ST2	1.31e-04	160	72	4	cb8d0dc1a6c69c7a85c5fdd8f0f6cca1b73dfc63
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLE BTLA PLCB2 MCOLN2	1.31e-04	160	72	4	cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHISA9 PTPRZ1 AHR NBEA	1.34e-04	161	72	4	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|356C / Donor, Lineage, Cell class and subclass (all cells)	ZNF211 LRRC37A LRRC37A2 PLCB2	1.44e-04	164	72	4	d5bb57c321f2973836efc8990449494cc1fb87c7
ToppCell	droplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ORC1 IGF2 TONSL SPAG5	1.48e-04	165	72	4	96f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCell	BAL-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	ORC1 TONSL C1QTNF12 SPAG5	1.55e-04	167	72	4	6c5aa9077ae7eb8887269d405972bd5b31596b19
ToppCell	mild_COVID-19_(asymptomatic)-Plasmablast\|World / disease group, cell group and cell class (v2)	ORC1 IGF1 BTLA GPRC5D	1.55e-04	167	72	4	f26ae4de4804a3486502e3df37eabf3dfca688f5
ToppCell	LA-16._Neuronal\|World / Chamber and Cluster_Paper	SHISA9 PTPRZ1 AHR HS3ST2	1.58e-04	168	72	4	2fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCell	LA-16._Neuronal\|LA / Chamber and Cluster_Paper	SHISA9 PTPRZ1 AHR HS3ST2	1.58e-04	168	72	4	c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHISA9 IGF1 GSTO2 DOCK6	1.62e-04	169	72	4	780fb0050852626062a729dd1b82b0cf61e7e9ca
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	SHISA9 PTPRZ1 AHR HS3ST2	1.62e-04	169	72	4	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GPR157 GPAT3 IRAK2 MCOLN2	1.66e-04	170	72	4	cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ORC1 IGF1 GPRC5D SPAG5	1.69e-04	171	72	4	13126a3fbee181412c13ffb0c347277b9d8f16f7
ToppCell	CD8+_Memory_T_cell-FLU-3\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ORC1 RBSN POLE PTCH2	1.73e-04	172	72	4	45ac433dbb3796f69e886c04457b2971403050ee
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYK2 AHRR GPR157 SSPOP	1.73e-04	172	72	4	c5caae0b21e35a2d5dcd898fbfa1ef33f92c019f
ToppCell	facs-Lung-EPCAM-18m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYK2 AHRR GPR157 SSPOP	1.73e-04	172	72	4	7c085c02b59e24e2a2cd393b5e692f9fb19257fe
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF211 LRRC37A LRRC37A2 PLCB2	1.77e-04	173	72	4	090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISL2 BTLA GSTO2 MCOLN2	1.81e-04	174	72	4	c92eec5a14ca5269673582dd115ead8516e64c3e
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF211 LRRC37A LRRC37A2 PLCB2	1.81e-04	174	72	4	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	ASK452-Immune-B_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	LRRC37A3 LRRC37A2 SPAG5 MCOLN2	1.81e-04	174	72	4	69723f5666abc3af5f0431901a60246c9915ef81
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF2 NGF NBEA HEATR5A	1.89e-04	176	72	4	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	Adult-Immune-dendritic_cell-D175\|Adult / Lineage, Cell type, age group and donor	GPR157 IRAK2 BTLA MCOLN2	1.89e-04	176	72	4	1f0f1f953e6d61119f342de0d980aa1287511dba
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLE PTCH2 NHEJ1 SPAG5	1.93e-04	177	72	4	3e149bff1f1b393a7abe98984e37981c8296f95d
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ORC1 IGF2 PTPRZ1 NGF	1.93e-04	177	72	4	4553ee8cd9c24db6511b09fe49ed11a89e7cde9e
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BTLA TRIM40 ENDOV MCOLN2	1.93e-04	177	72	4	a58c93be9767e3fe8fbb6b0db1210d3a33aac662
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BTLA TRIM40 ENDOV MCOLN2	1.93e-04	177	72	4	3ed383e5c0b15d9d5e75b98cf6d10609f48fc422
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BTLA PLCB2 NHEJ1 TRIM14	1.98e-04	178	72	4	ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BTLA PLCB2 NHEJ1 TRIM14	1.98e-04	178	72	4	6c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BTLA PLCB2 NHEJ1 TRIM14	1.98e-04	178	72	4	cd85dcefe94ee742db64b63e105e13532321894a
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BTLA TRIM40 ENDOV MCOLN2	1.98e-04	178	72	4	9b932b677ae05ac6e12cd6ce97789f8c10e4790b
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GPAT3 IRAK2 BTLA MCOLN2	2.02e-04	179	72	4	9fc44637c9a7551fd47b8533e45a9c199e164a95
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IRF2BP1 LRRC37A3 PTPRZ1 ZNF319	2.06e-04	180	72	4	c72f15763ba707189e29c85db533557f01c7fdb1
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CPAMD8 IRAK2 DOCK6 SH3RF3	2.06e-04	180	72	4	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	RA-16._Neuronal\|RA / Chamber and Cluster_Paper	SHISA9 PTPRZ1 AHR HS3ST2	2.06e-04	180	72	4	5842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCell	Severe-Myeloid-mDC\|Severe / Condition, Lineage, Cell class and cell subclass	GPR157 GPAT3 BTLA MCOLN2	2.11e-04	181	72	4	00f2949b609ac21bd2da6fd8f685739eeb2f48ad
ToppCell	Severe-Myeloid-mDC-\|Severe / Condition, Lineage, Cell class and cell subclass	GPR157 GPAT3 BTLA MCOLN2	2.11e-04	181	72	4	51ded98c76ec35ab1d24ac3ab98280381daa9831
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AHRR MANBA GPAT3 PLCB2	2.15e-04	182	72	4	57f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCell	COVID-19-APC-like-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	GPAT3 AHR BTLA MCOLN2	2.20e-04	183	72	4	703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	IGF1 IRAK2 ISL2 GPRC5D	2.20e-04	183	72	4	dd15e1463a0d57d14800de0df0645c81c56926ae
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	IGF1 IRAK2 ISL2 GPRC5D	2.20e-04	183	72	4	8ace19c38b89556d2504258a63aa5a2b14f5cd36
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ORC1 IRF2BP1 MEGF8 ATP2A1	2.20e-04	183	72	4	f03d87b556a3d50360d4eb6126b3466fe7266677
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ORC1 AP5B1 POLE SPAG5	2.20e-04	183	72	4	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	COVID-19-APC-like\|COVID-19 / group, cell type (main and fine annotations)	GPAT3 AHR BTLA MCOLN2	2.20e-04	183	72	4	b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.24e-04	184	72	4	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.24e-04	184	72	4	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IGF1 ROR2 NGF SSPOP	2.24e-04	184	72	4	ae0a77e3e520a246b17776bb19503519636b02ee
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PIGH TONSL SAE1 MDM2	2.29e-04	185	72	4	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-conventional_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR157 GPAT3 BTLA MCOLN2	2.29e-04	185	72	4	209c7d769dd01c349f0a6d147ac9d6225a85160f
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR157 GPAT3 BTLA MCOLN2	2.29e-04	185	72	4	1f37191eeddaf95e1ad1a206fee86525a2e94e51
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR157 GPAT3 BTLA MCOLN2	2.29e-04	185	72	4	70d3f804b43a8843c5af53aefe677fdfc8bb61ff
ToppCell	IPF-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.34e-04	186	72	4	962c2dada19185628ead77c32fcb07fa95114247
ToppCell	Control-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.34e-04	186	72	4	3de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCell	Control-Myeloid-cDC1\|Control / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.34e-04	186	72	4	b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ORC1 IGF1 NGF PTCH2	2.38e-04	187	72	4	fa8f221b4c2df61eadaa9c77e4cf45848b00330b
ToppCell	367C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	GPR157 IRAK2 BTLA MCOLN2	2.38e-04	187	72	4	3748203b62abf51b74dfcfc4f18b3ba831b63a96
ToppCell	IPF-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.43e-04	188	72	4	47bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GPR157 IRAK2 BTLA MCOLN2	2.43e-04	188	72	4	d5ce3ffe783c322b4765b790e861727e46bc34b3
ToppCell	IPF-Myeloid-cDC1\|IPF / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.43e-04	188	72	4	2331a2bae1383820d598e93aa86c75b101069bac
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cacng4_(Non-anterior_nuclei)\|Thalamus / BrainAtlas - Mouse McCarroll V32	NGF TRIM40 ATP2A1	2.54e-04	76	72	3	4afc8d0e79870c635a89dd8e7ca91ebfe482b4ab
ToppCell	Control-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	MANBA GPAT3 IRAK2 MCOLN2	2.58e-04	191	72	4	11dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCell	Adult-Immune-monocyte-D175\|Adult / Lineage, Cell type, age group and donor	GPAT3 IRAK2 PLCB2 DDX60L	2.58e-04	191	72	4	cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.58e-04	191	72	4	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	GPR157 IRAK2 BTLA MCOLN2	2.64e-04	192	72	4	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LRRC37A POLE PTCH2 MCOLN2	2.64e-04	192	72	4	930319cbd82b9e54864147ffcdc8bd0ea7b937be
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LRRC37A POLE PTCH2 MCOLN2	2.64e-04	192	72	4	c7bcebcb88a25b2c97d798120efa9d5958e7f798
ToppCell	367C-Myeloid-Dendritic\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	GPR157 GPAT3 AHR MCOLN2	2.64e-04	192	72	4	877aaf61d8fc40e7013944a0180306dd0bb0557f
ToppCell	367C-Myeloid-Dendritic\|367C / Donor, Lineage, Cell class and subclass (all cells)	GPR157 GPAT3 AHR MCOLN2	2.69e-04	193	72	4	365e831ae6ac67fb36d8d70ef139f4ae7e32c83f
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GPR157 GPAT3 IRAK2 MCOLN2	2.69e-04	193	72	4	704378de39e1b6f108ab5b0ecbd594d414ec8ae4
ToppCell	10x5'v1-week_14-16-Myeloid_DC-DC-DC2\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GPAT3 AHR BTLA MCOLN2	2.74e-04	194	72	4	a0cfc8c1cdc0722db39170e4417615b6e6b85041
ToppCell	3'_v3-blood-Lymphocytic_NK-Cycling_NK\|blood / Manually curated celltypes from each tissue	ORC1 POLE SAE1 SPAG5	2.74e-04	194	72	4	bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPR157 GPAT3 IRAK2 MCOLN2	2.74e-04	194	72	4	36f8ae4f2b3bf802f6ff0e9fc79e7f170f96ae8b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROR2 NGF PTCH2 SH3RF3	2.74e-04	194	72	4	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GPAT3 IRAK2 BTLA MCOLN2	2.74e-04	194	72	4	5a048bd2af30975fdc57ff40bc49aa5811c830d8
ToppCell	Control-Myeloid-Migratory_DC\|Control / Condition, Lineage and Cell class	GPR157 GPAT3 IRAK2 MCOLN2	2.74e-04	194	72	4	374076e60dcee83eb1814aa6b55b77668909f40b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROR2 NGF PTCH2 SH3RF3	2.74e-04	194	72	4	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	Control-Myeloid-Migratory_DC\|Myeloid / Condition, Lineage and Cell class	GPR157 GPAT3 IRAK2 MCOLN2	2.80e-04	195	72	4	9f1ad04abc6a6c5e093ea24b60732871b1fad5a4
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	MANBA PLCB2 DDX60L HS3ST2	2.80e-04	195	72	4	ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)\|Striatum / BrainAtlas - Mouse McCarroll V32	IL25 BTLA SSPOP	2.85e-04	79	72	3	239d34f40c3a96186231f3aabd41c4988af3f372
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf\|Striatum / BrainAtlas - Mouse McCarroll V32	IL25 BTLA SSPOP	2.85e-04	79	72	3	a60fcbb278ba629af922c53faf58e4d96c537b15
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IRAK2 BTLA PLCB2 MCOLN2	2.85e-04	196	72	4	b71d711be5609115b00a57700885aca608920896
ToppCell	COPD-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	CPAMD8 RBSN IGF2 AHR	2.85e-04	196	72	4	af96fb94886e9395f3e2cd0a293af29229d017fe
ToppCell	Monocytes-cDCs\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	GPAT3 AHR BTLA MCOLN2	2.91e-04	197	72	4	15cb9fe1c3bab80bd24728fd9ac7ba385912ac33
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPR157 GPAT3 BTLA MCOLN2	2.91e-04	197	72	4	81dd7f9318f0ba175352e5156c24772427e0b34f
ToppCell	distal-mesenchymal-Adventitial_Fibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	IGF1 ROR2 NGF HS3ST2	2.96e-04	198	72	4	bfd720e2dae3b6b3dc2bf8b2096c554fd456e756
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR157 GPAT3 HS3ST2 MCOLN2	2.96e-04	198	72	4	455d55cfdeb8b6b13c289b53e1a5184a574e2e35
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IRAK2 BTLA PLCB2 MCOLN2	2.96e-04	198	72	4	fa5c15a656d4132950092919600e270f1fd79abf
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGF1 IGF2 ROR2 NGF	2.96e-04	198	72	4	c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell	BAL-Severe-Myeloid-cDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GPR157 GPAT3 BTLA MCOLN2	3.02e-04	199	72	4	0b20ae65b9340d844e271acda9e116d98fc1cc69
Drug	1-methylphenanthrene	AHRR AHR SPAG5	4.91e-06	11	72	3	CID000013257
Drug	PCB 52	AHRR MAS1L AHR SPAG5	1.24e-05	45	72	4	CID000037248
Drug	PCB 118	AHRR AHR SPAG5	1.65e-05	16	72	3	CID000035823
Drug	annomontine	AHRR AHR	2.95e-05	3	72	2	ctd:C508838
Drug	6-chlorochrysene	AHRR AHR	2.95e-05	3	72	2	CID000056969
Drug	Tadjakonine [11087-94-8]; Up 200; 7.4uM; PC3; HT_HG-U133A	MANBA FBXO11 MLLT10 MDM2 DOCK6 TRIM14	3.47e-05	194	72	6	4599_UP
Drug	Clozapine [5786-21-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	POLE TRAPPC10 IL17RC MDM2 TRIM14 TGS1	3.78e-05	197	72	6	2644_DN
Drug	Erythromycin [114-07-8]; Up 200; 5.4uM; PC3; HG-U133A	IRF2BP1 ATXN10 MLLT10 DOCK6 TRIM14 DICER1	3.89e-05	198	72	6	1928_UP
Drug	hexachlorodibenzo-p-dioxin	AHRR IGF1 AHR	5.85e-05	24	72	3	CID000038251
Drug	1,2,3,4,6,7,8-heptachlorodibenzofuran	AHRR AHR	5.89e-05	4	72	2	ctd:C473650
Drug	tasquinimod	AHRR AHR	5.89e-05	4	72	2	ctd:C516109
Drug	tetrachlorodibenzofuran	AHRR AHR	5.89e-05	4	72	2	CID000035331
Drug	p-chlorophenyl methyl sulfoxide	IGF1 IGF2	5.89e-05	4	72	2	CID000013626
Drug	1,3,6,8-tetrachlorodibenzo-p-dioxin	AHRR AHR	5.89e-05	4	72	2	CID000036474
Drug	1,2,3,4,7,8-hexachlorodibenzodioxin	IGF1 AHR	5.89e-05	4	72	2	ctd:C078219
Drug	Carbolines	AHRR AHR	5.89e-05	4	72	2	ctd:D002243
Drug	picene	AHRR AHR	5.89e-05	4	72	2	CID000009162
Disease	alcoholic neuropathy (biomarker_via_orthology)	IGF1 IGF2	1.76e-05	3	72	2	DOID:14183 (biomarker_via_orthology)
Disease	congenital disorder of glycosylation Ia (is_marker_for)	IGF1 IGF2	3.51e-05	4	72	2	DOID:0080552 (is_marker_for)
Disease	Adenocarcinoma of large intestine	TYK2 POLE ROR2 MDM2	9.14e-05	96	72	4	C1319315
Disease	Early Pregnancy Loss	IGF1 IGF2 AHR SPAG5	1.49e-04	109	72	4	C3830362
Disease	Miscarriage	IGF1 IGF2 AHR SPAG5	1.49e-04	109	72	4	C4552766
Disease	Spontaneous abortion	IGF1 IGF2 AHR SPAG5	1.49e-04	109	72	4	C0000786
Disease	Abortion, Tubal	IGF1 IGF2 AHR SPAG5	1.49e-04	109	72	4	C0000822
Disease	IGF-1 measurement	IGF1 IGF2 DET1 DMRTA1 DDX60L ATXN10 DOCK6	1.89e-04	488	72	7	EFO_0004627
Disease	Pituitary Adenoma	IGF1 DICER1	2.09e-04	9	72	2	C0032000
Disease	stomach cancer (is_marker_for)	FBXO11 NBEA DOCK6 DICER1	4.10e-04	142	72	4	DOID:10534 (is_marker_for)
Disease	hematologic cancer (implicated_via_orthology)	TYK2 SAE1	4.50e-04	13	72	2	DOID:2531 (implicated_via_orthology)
Disease	breast cancer (biomarker_via_orthology)	IGF1 MDM2	4.50e-04	13	72	2	DOID:1612 (biomarker_via_orthology)
Disease	Rhabdomyosarcoma	IGF2 DICER1	6.04e-04	15	72	2	C0035412
Disease	multiple sclerosis	TYK2 CPAMD8 MANBA SAE1 DMRTA1 HS3ST2 TRIM14	6.15e-04	594	72	7	MONDO_0005301
Disease	Chronic myeloproliferative disorder	ORC1 IGF1	9.77e-04	19	72	2	C1292778
Disease	Cardiac Hypertrophy	IGF1 AHR RBCK1	1.07e-03	82	72	3	C1383860
Disease	Cardiomegaly	IGF1 AHR RBCK1	1.07e-03	82	72	3	C0018800
Disease	Fetal Growth Retardation	ORC1 IGF2	1.08e-03	20	72	2	C0015934
Disease	Nerve Degeneration	IGF1 IGF2 NGF	1.11e-03	83	72	3	C0027746
Disease	Lung Injury	NGF AHR	1.20e-03	21	72	2	C0273115
Disease	Chronic Lung Injury	NGF AHR	1.20e-03	21	72	2	C2350344
Disease	Seckel syndrome	ORC1 IGF1	1.31e-03	22	72	2	C0265202
Disease	Lewy Body Disease	IGF2 NGF	1.31e-03	22	72	2	C0752347
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	IGF1 IGF2	1.57e-03	24	72	2	DOID:3827 (biomarker_via_orthology)
Disease	Colitis	IGF1 AHR	1.70e-03	25	72	2	C0009319
Disease	Bilateral Wilms Tumor	IGF2 DICER1	2.28e-03	29	72	2	C2930471

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTRCFICRVRCLLDS	AHRR	221	A9YTQ3
MERCFICRLRCLLDN	AHR	216	P35869
LLITTCFCLFCCLRR	BTLA	166	Q7Z6A9
ITECFRCLRNACIEC	ATXN10	81	Q9UBB4
ARDVVCVLICIESLC	C1QTNF12	226	Q5T7M4
NRECSLFTDDCRCVI	DET1	141	Q7L5Y6
CVRLAERVVALICCE	DICER1	686	Q9UPY3
LPLAEQREACRRACC	ATP2A1	661	O14983
CSCKQADICVREIAR	PDS5A	581	Q29RF7
DDRIRCCTHCKDTLL	RBSN	246	Q9H1K0
SFLCCCDDLGRSRLL	HS3ST2	36	Q9Y278
IILLCLIEICCHRRS	LRRC37A3	1596	O60309
IILFCLIVICCHRRS	LRRC37A2	1596	A6NM11
IILFCLIVICCHRRS	LRRC37A	1596	A6NMS7
RFIRIDTACVCVLSR	NGF	221	P01138
ERFFQAELQICLRCC	IRAK2	251	O43187
VLRECLHTFCRECLQ	RBCK1	296	Q9BYM8
SLQEVEDFCRLRCLC	DDX60L	286	Q5H9U9
EDFCRLRCLCVAFQL	DDX60L	291	Q5H9U9
LTKECLVALRCGREC	GSTO2	126	Q9H4Y5
SPEECRRLRTCSECL	MEGF8	1921	Q7Z7M0
LQATACECLRELESC	AP5B1	146	Q2VPB7
VICRSCNFCRDLDLC	POLE	2156	Q07864
RFLACIQLLCVCRLD	PTPRZ1	6	P23471
LLCTCDKAAIECLAR	OC90	161	Q02509
LCLLVAISTERCVCV	MAS1L	161	P35410
RCLDICRRATEICEF	ORC1	721	Q13415
IDAVCCRRCVSFILR	HEATR5A	346	Q86XA9
TELCADLCLRLLRHC	DOCK6	1456	Q96HP0
SELVHLTCCRICVRA	GPAT3	191	Q53EU6
ELCILYRSCRQECPL	GPRC5D	261	Q9NZD1
LCRAACVCKRFSELA	FBXO11	176	Q86XK2
CLTCVRFRALRECVV	CPAMD8	1621	Q8IZJ3
CACAKCTLIAERQRV	DMRTA1	121	Q5VZB9
IVEECCFRSCDLALL	IGF2	66	P01344
LCTRAVRTRLFSLCC	GPR157	281	Q5UAW9
ELLRRCGNCTRESCV	MANBA	756	O00462
IVDECCFRSCDLRRL	IGF1	91	P05019
CLERRLYRVSLACVC	IL25	156	Q9H293
SLEAAVRLTCCCCRF	ENDOV	216	Q8N8Q3
KESSAFLSCICCRRR	MCOLN2	541	Q8IZK6
LCCTLCRERLEDTHF	IRF2BP1	501	Q8IU81
LVLRCQKETDCDLCL	IL17RC	141	Q8NAC3
HIECFRCSVCSRQLL	ISL2	111	Q96A47
LFCETCDRLTCRDCQ	TRIM33	286	Q9UPN9
FCEESRLLLCVECLV	TRIM40	81	Q6P9F5
SRRAETLVCCCFDLL	SPAG5	536	Q96R06
ECLSAERRCDLRPDC	SSPOP	2476	A2VEC9
CIQCTRCIRFASEIA	NDUFS1	176	P28331
CLRLVCCVAVRNCLE	NBEA	1471	Q8NFP9
RRCFLLAVCILLVCT	PTCH2	961	Q9Y6C5
PRCCRICFEERRDEL	KCNV2	196	Q8TDN2
SLALCVIREICCERS	MDM2	196	Q00987
CFLTELCARVCRAQE	SHISA9	11	B4DS77
FDAVCLTCCSRDVIV	SAE1	126	Q9UBE0
SCDCVADALILRVRS	NHEJ1	96	Q9H9Q4
LCRDECEVLESDLCR	ROR2	251	Q01974
CESQERAARVRCELC	MLLT10	71	P55197
CNKQITRCLIECRDE	CNOT1	1706	A5YKK6
FCLLCKRECIEARIL	RLF	556	Q13129
VCSRHELRCPECRIL	SH3RF3	86	Q8TEJ3
GDKAVRDLCRCLSLC	TONSL	1261	Q96HA7
SCEICCLVLRDILHL	ZNF211	111	Q13398
CREFCLSCPRLSLRS	PIGH	26	Q14442
RQVLLSGCRCVELDC	PLCB2	346	Q00722
VAELFCRRCRRCVCA	TRIM14	31	Q14142
NRIVERCCRCLRFAV	TNPO3	656	Q9Y5L0
CAAAEKPLRCTLCER	ZNF319	451	Q9P2F9
SRLRFLSCVVCEKEC	ZBED9	596	Q6R2W3
IEEREDCKILCLCSR	TGS1	16	Q96RS0
CIVRTLRIICVCAED	VPS9D1	531	Q9Y2B5
SCLEVLQRIEGCCDR	TRAPPC10	361	P48553
LFCEDDQRPVCLVCR	TRIM4	96	Q9C037
CLLRAGDDCFSLRRC	TYK2	536	P29597