Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	axon guidance receptor activity	EPHB3 ROBO1 EPHB1	1.39e-06	13	35	3	GO:0008046
GeneOntologyMolecularFunction	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	NANOGP8 NANOG	1.79e-05	4	35	2	GO:0001010
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHB3 EPHB1	3.09e-04	15	35	2	GO:0005005
GeneOntologyMolecularFunction	ephrin receptor activity	EPHB3 EPHB1	5.01e-04	19	35	2	GO:0005003
GeneOntologyMolecularFunction	lysine-acetylated histone binding	NANOGP8 NANOG	1.26e-03	30	35	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	NANOGP8 NANOG	1.34e-03	31	35	2	GO:0140033
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	IRF8 ZBTB10 NANOGP8 NANOG	2.29e-03	320	35	4	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	IRF8 ZBTB10 NANOGP8 NANOG	2.45e-03	326	35	4	GO:0001217
GeneOntologyBiologicalProcess	dendrite development	EPHB3 SCARF1 ROBO1 PIAS2 PAK4 EPHB1 PHACTR1	1.56e-06	335	36	7	GO:0016358
GeneOntologyBiologicalProcess	negative regulation of endodermal cell fate specification	NANOGP8 NANOG	1.77e-05	4	36	2	GO:0042664
GeneOntologyBiologicalProcess	dendrite morphogenesis	EPHB3 ROBO1 PIAS2 EPHB1 PHACTR1	2.29e-05	198	36	5	GO:0048813
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	BLNK EPHB3 TXNIP ROBO1 NANOGP8 MTMR4 PRDM14 NANOG STAT5A EPHB1	2.45e-05	1186	36	10	GO:0007167
GeneOntologyBiologicalProcess	regulation of endodermal cell fate specification	NANOGP8 NANOG	2.95e-05	5	36	2	GO:0042663
GeneOntologyBiologicalProcess	negative regulation of endodermal cell differentiation	NANOGP8 NANOG	4.42e-05	6	36	2	GO:1903225
GeneOntologyBiologicalProcess	negative regulation of cell fate specification	NANOGP8 NANOG	8.24e-05	8	36	2	GO:0009996
GeneOntologyBiologicalProcess	negative regulation of cellular response to growth factor stimulus	NANOGP8 MTMR4 PRDM14 NANOG	1.32e-04	150	36	4	GO:0090288
GeneOntologyBiologicalProcess	regulation of endodermal cell differentiation	NANOGP8 NANOG	1.32e-04	10	36	2	GO:1903224
GeneOntologyBiologicalProcess	endodermal cell fate specification	NANOGP8 NANOG	1.61e-04	11	36	2	GO:0001714
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine kinase signaling pathway	BLNK EPHB3 TXNIP ROBO1 PRDM14 STAT5A EPHB1	2.65e-04	747	36	7	GO:0007169
GeneOntologyBiologicalProcess	neuron projection development	EPHB3 SCARF1 ROBO1 FRYL PRKCSH PIAS2 PAK4 EPHB1 PHACTR1	2.79e-04	1285	36	9	GO:0031175
GeneOntologyBiologicalProcess	cell dedifferentiation	NANOGP8 NANOG	3.07e-04	15	36	2	GO:0043697
GeneOntologyBiologicalProcess	dedifferentiation	NANOGP8 NANOG	3.07e-04	15	36	2	GO:0043696
GeneOntologyBiologicalProcess	negative regulation of BMP signaling pathway	NANOGP8 MTMR4 NANOG	3.66e-04	80	36	3	GO:0030514
GeneOntologyBiologicalProcess	negative regulation of cell fate commitment	NANOGP8 NANOG	3.96e-04	17	36	2	GO:0010454
GeneOntologyBiologicalProcess	regulation of cell division	TXNIP NANOGP8 RAB11FIP4 NANOG	4.04e-04	201	36	4	GO:0051302
GeneOntologyBiologicalProcess	mammary gland epithelium development	ROBO1 IQGAP3 STAT5A	4.22e-04	84	36	3	GO:0061180
GeneOntologyBiologicalProcess	endodermal cell fate commitment	NANOGP8 NANOG	4.45e-04	18	36	2	GO:0001711
GeneOntologyBiologicalProcess	regulation of stem cell division	NANOGP8 NANOG	4.45e-04	18	36	2	GO:2000035
GeneOntologyBiologicalProcess	regulation of mammary gland epithelial cell proliferation	ROBO1 IQGAP3	6.09e-04	21	36	2	GO:0033599
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	ROBO1 NANOGP8 MTMR4 PRDM14 NANOG	7.02e-04	412	36	5	GO:0090287
GeneOntologyBiologicalProcess	neuron development	EPHB3 SCARF1 ROBO1 FRYL PRKCSH PIAS2 PAK4 EPHB1 PHACTR1	7.24e-04	1463	36	9	GO:0048666
GeneOntologyBiologicalProcess	mesodermal cell fate commitment	NANOGP8 NANOG	7.32e-04	23	36	2	GO:0001710
GeneOntologyBiologicalProcess	retinal ganglion cell axon guidance	EPHB3 EPHB1	7.98e-04	24	36	2	GO:0031290
GeneOntologyBiologicalProcess	regulation of cell fate specification	NANOGP8 NANOG	1.17e-03	29	36	2	GO:0042659
Domain	Znf_FYVE_PHD	KMT2D MTMR4 KAT6B PRDM14 UBR7	8.74e-06	147	36	5	IPR011011
Domain	RECEPTOR_TYR_KIN_V_2	EPHB3 EPHB1	3.24e-04	14	36	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB3 EPHB1	3.24e-04	14	36	2	PS00790
Domain	EphA2_TM	EPHB3 EPHB1	3.24e-04	14	36	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB3 EPHB1	3.24e-04	14	36	2	IPR016257
Domain	Eph_TM	EPHB3 EPHB1	3.24e-04	14	36	2	IPR027936
Domain	Ephrin_rcpt_lig-bd_dom	EPHB3 EPHB1	3.24e-04	14	36	2	IPR001090
Domain	Tyr_kinase_rcpt_V_CS	EPHB3 EPHB1	3.24e-04	14	36	2	IPR001426
Domain	EPH_LBD	EPHB3 EPHB1	3.24e-04	14	36	2	PS51550
Domain	EPH_lbd	EPHB3 EPHB1	3.24e-04	14	36	2	SM00615
Domain	Ephrin_lbd	EPHB3 EPHB1	3.24e-04	14	36	2	PF01404
Domain	-	EPHB3 HECTD1 EPHB1	3.73e-04	73	36	3	2.60.120.260
Domain	FN3	EPHB3 PAPPA2 ROBO1 EPHB1	4.28e-04	185	36	4	SM00060
Domain	PHD	KMT2D KAT6B UBR7	6.67e-04	89	36	3	SM00249
Domain	FN3_dom	EPHB3 PAPPA2 ROBO1 EPHB1	6.78e-04	209	36	4	IPR003961
Domain	Znf_PHD	KMT2D KAT6B UBR7	7.11e-04	91	36	3	IPR001965
Domain	Galactose-bd-like	EPHB3 HECTD1 EPHB1	7.82e-04	94	36	3	IPR008979
Domain	ZF_PHD_2	KMT2D KAT6B UBR7	8.06e-04	95	36	3	PS50016
Domain	ZF_PHD_1	KMT2D KAT6B UBR7	8.31e-04	96	36	3	PS01359
Domain	Ephrin_rec_like	EPHB3 EPHB1	1.05e-03	25	36	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB3 EPHB1	1.05e-03	25	36	2	IPR011641
Domain	-	KMT2D MTMR4 KAT6B PIAS2 UBR7	1.60e-03	449	36	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KMT2D MTMR4 KAT6B PIAS2 UBR7	1.76e-03	459	36	5	IPR013083
Domain	SET	KMT2D PRDM14	2.83e-03	41	36	2	PF00856
Domain	Growth_fac_rcpt_	EPHB3 SCARF1 EPHB1	3.33e-03	156	36	3	IPR009030
Domain	SET	KMT2D PRDM14	3.54e-03	46	36	2	SM00317
Domain	fn3	EPHB3 ROBO1 EPHB1	3.71e-03	162	36	3	PF00041
Domain	SET_dom	KMT2D PRDM14	4.18e-03	50	36	2	IPR001214
Domain	SET	KMT2D PRDM14	4.18e-03	50	36	2	PS50280
Domain	FN3	EPHB3 ROBO1 EPHB1	6.57e-03	199	36	3	PS50853
Domain	SAM_1	EPHB3 EPHB1	7.60e-03	68	36	2	PF00536
Domain	-	EPHB3 PAPPA2 ROBO1 PDCD1 EPHB1	8.42e-03	663	36	5	2.60.40.10
Domain	PHD	KMT2D KAT6B	9.18e-03	75	36	2	PF00628
Domain	IGv	ROBO1 PDCD1	9.18e-03	75	36	2	SM00406
Pathway	WP_EXTRAFOLLICULAR_AND_FOLLICULAR_B_CELL_ACTIVATION_BY_SARSCOV2	BLNK IRF8 PDCD1 STAT5A	1.50e-05	74	29	4	M45517
Pathway	WP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT	EPHB3 PAK4 EPHB1	7.35e-05	40	29	3	M39798
Pathway	WP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER	EPHB3 PAK4 EPHB1	9.14e-05	43	29	3	M39788
Pathway	KEGG_AXON_GUIDANCE	EPHB3 ROBO1 PAK4 EPHB1	1.33e-04	129	29	4	M5539
Pathway	REACTOME_ACTIVATION_OF_RAC1	ROBO1 PAK4	3.14e-04	13	29	2	M6322
Pathway	REACTOME_EPHRIN_SIGNALING	EPHB3 EPHB1	6.13e-04	18	29	2	MM15024
Pathway	REACTOME_EPHRIN_SIGNALING	EPHB3 EPHB1	6.84e-04	19	29	2	M27310
Pubmed	Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation.	NANOGP8 KAT6B NANOG	2.03e-08	6	36	3	30790630
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	NANOGP8 KMT2D NANOG	1.67e-07	11	36	3	37012455
Pubmed	Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.	NANOGP8 PRDM14 NANOG	2.23e-07	12	36	3	24268575
Pubmed	Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.	NANOGP8 PRDM14 NANOG	2.89e-07	13	36	3	26523946
Pubmed	Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.	NANOGP8 PRDM14 NANOG	4.59e-07	15	36	3	29320730
Pubmed	The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.	EPHB3 ROBO1 EPHB1	8.22e-07	18	36	3	16854408
Pubmed	Functional evidence that the self-renewal gene NANOG regulates human tumor development.	NANOGP8 NANOG	1.04e-06	2	36	2	19415763
Pubmed	Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.	NANOGP8 NANOG	1.04e-06	2	36	2	24598770
Pubmed	Differential expression of nanog1 and nanogp8 in colon cancer cells.	NANOGP8 NANOG	1.04e-06	2	36	2	22079639
Pubmed	STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T-cell sensitivity to PD-1-dependent immunoregulation.	PDCD1 STAT5A	1.04e-06	2	36	2	34453440
Pubmed	Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells.	NANOGP8 NANOG	1.04e-06	2	36	2	21136380
Pubmed	Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.	TNFRSF19 MUC5AC IQGAP3	2.31e-06	25	36	3	34391772
Pubmed	Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.	NANOGP8 NANOG	3.12e-06	3	36	2	19447925
Pubmed	The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.	NANOGP8 NANOG	3.12e-06	3	36	2	30814124
Pubmed	Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis.	IRF8 STAT5A	3.12e-06	3	36	2	24091328
Pubmed	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	30846691
Pubmed	Generation of germline-competent induced pluripotent stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	17554338
Pubmed	Multiple phases in regulation of Nanog expression during pre-implantation development.	NANOGP8 NANOG	3.12e-06	3	36	2	26660234
Pubmed	Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.	NANOGP8 NANOG	3.12e-06	3	36	2	18177668
Pubmed	Expression of Nanog gene promotes NIH3T3 cell proliferation.	NANOGP8 NANOG	3.12e-06	3	36	2	16259959
Pubmed	A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	12609610
Pubmed	Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1.	NANOGP8 NANOG	3.12e-06	3	36	2	24227785
Pubmed	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.	MUC5AC PAK4	3.12e-06	3	36	2	17555715
Pubmed	Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.	NANOGP8 NANOG	3.12e-06	3	36	2	24929238
Pubmed	Nanog and transcriptional networks in embryonic stem cell pluripotency.	NANOGP8 NANOG	3.12e-06	3	36	2	17211451
Pubmed	The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.	NANOGP8 NANOG	3.12e-06	3	36	2	23770853
Pubmed	The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.	NANOGP8 NANOG	3.12e-06	3	36	2	15502159
Pubmed	Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.	NANOGP8 NANOG	3.12e-06	3	36	2	20574542
Pubmed	lincRNAs act in the circuitry controlling pluripotency and differentiation.	NANOGP8 NANOG	3.12e-06	3	36	2	21874018
Pubmed	Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.	NANOGP8 NANOG	3.12e-06	3	36	2	23054952
Pubmed	Nanog-independent reprogramming to iPSCs with canonical factors.	NANOGP8 NANOG	3.12e-06	3	36	2	24527385
Pubmed	Aromatic residues in the C-terminal domain 2 are required for Nanog to mediate LIF-independent self-renewal of mouse embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	18086680
Pubmed	A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.	EPHB3 EPHB1	3.12e-06	3	36	2	23143520
Pubmed	Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	17204467
Pubmed	CrxOS maintains the self-renewal capacity of murine embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	19800316
Pubmed	Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	23200040
Pubmed	Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.	NANOGP8 NANOG	3.12e-06	3	36	2	26975336
Pubmed	Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.	NANOGP8 NANOG	3.12e-06	3	36	2	23329853
Pubmed	NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.	NANOGP8 NANOG	3.12e-06	3	36	2	26751055
Pubmed	Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	17352742
Pubmed	OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.	NANOGP8 NANOG	3.12e-06	3	36	2	23178592
Pubmed	Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency.	NANOGP8 NANOG	3.12e-06	3	36	2	25005472
Pubmed	Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts.	NANOGP8 NANOG	3.12e-06	3	36	2	16773043
Pubmed	Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.	NANOGP8 NANOG	3.12e-06	3	36	2	23665121
Pubmed	Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.	NANOGP8 NANOG	3.12e-06	3	36	2	26733157
Pubmed	mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells.	NANOGP8 NANOG	3.12e-06	3	36	2	23071603
Pubmed	Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.	NANOGP8 NANOG	3.12e-06	3	36	2	16501172
Pubmed	Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	19582141
Pubmed	NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.	NANOGP8 NANOG	3.12e-06	3	36	2	21119109
Pubmed	Pluripotency factor NANOG promotes germ cell maintenance in vitro without triggering dedifferentiation of spermatogonial stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	32145514
Pubmed	Nanog is the gateway to the pluripotent ground state.	NANOGP8 NANOG	3.12e-06	3	36	2	19703398
Pubmed	Nanog safeguards pluripotency and mediates germline development.	NANOGP8 NANOG	3.12e-06	3	36	2	18097409
Pubmed	Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.	NANOGP8 NANOG	3.12e-06	3	36	2	28636920
Pubmed	Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst.	NANOGP8 NANOG	3.12e-06	3	36	2	25753417
Pubmed	A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.	NANOGP8 NANOG	3.12e-06	3	36	2	20539761
Pubmed	Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.	NANOGP8 NANOG	3.12e-06	3	36	2	18584034
Pubmed	Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	21969378
Pubmed	The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.	NANOGP8 NANOG	3.12e-06	3	36	2	20661723
Pubmed	NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.	NANOGP8 NANOG	3.12e-06	3	36	2	29245050
Pubmed	Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype.	NANOGP8 NANOG	3.12e-06	3	36	2	22337995
Pubmed	The pluripotency rheostat Nanog functions as a dimer.	NANOGP8 NANOG	3.12e-06	3	36	2	18290762
Pubmed	Reprogramming of mouse fibroblasts into induced pluripotent stem cells with Nanog.	NANOGP8 NANOG	3.12e-06	3	36	2	23333380
Pubmed	Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.	NANOGP8 NANOG	3.12e-06	3	36	2	15494369
Pubmed	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	25825768
Pubmed	Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation.	NANOGP8 NANOG	3.12e-06	3	36	2	31891567
Pubmed	Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.	NANOGP8 NANOG	3.12e-06	3	36	2	14728807
Pubmed	Isolation and characterization of the murine Nanog gene promoter.	NANOGP8 NANOG	3.12e-06	3	36	2	15916719
Pubmed	Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia.	IRF8 STAT5A	3.12e-06	3	36	2	24753251
Pubmed	Nanog retrotransposed genes with functionally conserved open reading frames.	NANOGP8 NANOG	3.12e-06	3	36	2	16845474
Pubmed	Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.	NANOGP8 NANOG	3.12e-06	3	36	2	21194951
Pubmed	Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.	NANOGP8 NANOG	3.12e-06	3	36	2	22388986
Pubmed	NANOG changes in mouse kidneys with age.	NANOGP8 NANOG	3.12e-06	3	36	2	16313224
Pubmed	Nanog promotes transfer of pluripotency after cell fusion.	NANOGP8 NANOG	3.12e-06	3	36	2	16791199
Pubmed	Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6.	NANOGP8 NANOG	3.12e-06	3	36	2	33665763
Pubmed	Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	18024963
Pubmed	The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	27125671
Pubmed	EphB receptors couple dendritic filopodia motility to synapse formation.	EPHB3 EPHB1	3.12e-06	3	36	2	18614029
Pubmed	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.	NANOGP8 NANOG	3.12e-06	3	36	2	22028025
Pubmed	Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming.	NANOGP8 NANOG	3.12e-06	3	36	2	28457890
Pubmed	Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.	NANOGP8 NANOG	3.12e-06	3	36	2	18436640
Pubmed	Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	25410303
Pubmed	Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase.	EPHB3 EPHB1	3.12e-06	3	36	2	29731254
Pubmed	Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment.	NANOGP8 NANOG	3.12e-06	3	36	2	33334884
Pubmed	NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation.	NANOGP8 NANOG	3.12e-06	3	36	2	21499299
Pubmed	Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.	NANOGP8 NANOG	3.12e-06	3	36	2	33107035
Pubmed	Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.	EPHB3 EPHB1	3.12e-06	3	36	2	35025117
Pubmed	Forced expression of Nanog in hematopoietic stem cells results in a gammadeltaT-cell disorder.	NANOGP8 NANOG	3.12e-06	3	36	2	17360937
Pubmed	H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate.	NANOGP8 NANOG	3.12e-06	3	36	2	35976266
Pubmed	Nanog dynamics in single embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	26760119
Pubmed	Nanog is dispensable for the generation of induced pluripotent stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	24461999
Pubmed	Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing.	NANOGP8 NANOG	3.12e-06	3	36	2	30837263
Pubmed	Nanog induces hyperplasia without initiating tumors.	NANOGP8 NANOG	3.12e-06	3	36	2	25173648
Pubmed	Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function.	NANOGP8 NANOG	3.12e-06	3	36	2	27939294
Pubmed	Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification.	NANOGP8 NANOG	3.12e-06	3	36	2	24681518
Pubmed	Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming.	NANOGP8 NANOG	3.12e-06	3	36	2	26549484
Pubmed	Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1.	EPHB3 EPHB1	3.12e-06	3	36	2	25051176
Pubmed	Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation.	NANOGP8 NANOG	3.12e-06	3	36	2	18442017
Pubmed	Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells.	NANOGP8 NANOG	3.12e-06	3	36	2	21187909
Pubmed	Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter.	NANOGP8 NANOG	3.12e-06	3	36	2	16541131
Pubmed	Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.	NANOGP8 NANOG	3.12e-06	3	36	2	22142851
Cytoband	17q11.2	RAB11FIP4 STAT5A	3.40e-03	110	36	2	17q11.2
Cytoband	19q13.2	ZNF526 PAK4	7.38e-03	164	36	2	19q13.2
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB3 EPHB1	2.39e-04	14	30	2	1095
GeneFamily	Fibronectin type III domain containing	EPHB3 ROBO1 EPHB1	2.32e-03	160	30	3	555
GeneFamily	NKL subclass homeoboxes and pseudogenes	NANOGP8 NANOG	5.50e-03	67	30	2	519
GeneFamily	Sterile alpha motif domain containing	EPHB3 EPHB1	9.33e-03	88	30	2	760
GeneFamily	PHD finger proteins	KMT2D KAT6B	9.74e-03	90	30	2	88
GeneFamily	SH2 domain containing	BLNK STAT5A	1.21e-02	101	30	2	741
Coexpression	MIKKELSEN_PLURIPOTENT_STATE_UP	NANOGP8 KAT6B NANOG	8.57e-07	14	36	3	MM810
Coexpression	TRAVAGLINI_LUNG_B_CELL	BLNK IRF8 TXNIP CCDC50	5.98e-05	155	36	4	M41680
Coexpression	TESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_DN	NANOGP8 NANOG	8.20e-05	10	36	2	MM741
Coexpression	GSE32901_NAIVE_VS_TH1_CD4_TCELL_DN	BLNK IRF8 CCDC50 IQGAP3	8.56e-05	170	36	4	M8926
Coexpression	MIKKELSEN_PLURIPOTENT_STATE_UP	KAT6B NANOG	1.00e-04	11	36	2	M1922
Coexpression	HAY_BONE_MARROW_DENDRITIC_CELL	IRF8 CCDC50 EPHB1 PHACTR1	1.51e-04	197	36	4	M39194
Coexpression	GSE17721_CTRL_VS_POLYIC_6H_BMDC_DN	IRF8 ROBO1 FRYL NANOG	1.57e-04	199	36	4	M3716
Coexpression	GSE29618_MONOCYTE_VS_PDC_DAY7_FLU_VACCINE_DN	BLNK IRF8 EPHB1 PHACTR1	1.57e-04	199	36	4	M4964
Coexpression	GSE36392_EOSINOPHIL_VS_NEUTROPHIL_IL25_TREATED_LUNG_DN	IRF8 DPP9 PIAS2 UBR7	1.57e-04	199	36	4	M5284
Coexpression	GSE17721_POLYIC_VS_CPG_16H_BMDC_UP	TXNIP PDCD1 FRYL TOP3A	1.60e-04	200	36	4	M3950
ToppCell	LPS_only-Myeloid-Dendritic_cells-pDC\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BLNK IRF8 CCDC50 PDCD1 EPHB1	7.90e-08	135	36	5	0afe232aa1a1e6c37a5b3183b67d7fa07e0ea791
ToppCell	Leuk-UTI-Myeloid-tDC\|Leuk-UTI / Disease, Lineage and Cell Type	IRF8 ZBTB10 CCDC50 EPHB1 PHACTR1	1.90e-07	161	36	5	51b9f60986ed2e8e2297d31c80462c3ab65a2e5e
ToppCell	ICU-SEP-Myeloid-pDC\|ICU-SEP / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	2.56e-07	171	36	5	72c448a0dc4c569bd6b465f9aa395f38034e7ea6
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 CCDC50 EPHB1 PHACTR1	2.56e-07	171	36	5	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 CCDC50 EPHB1 PHACTR1	2.56e-07	171	36	5	debbb071d260639b16269c94d172766908325c58
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BLNK IRF8 CCDC50 EPHB1 PHACTR1	2.64e-07	172	36	5	3aed10e6db48254f4cae12fbe52d1a1fc6cf2dce
ToppCell	IIF-Myeloid-pDC\|IIF / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	2.87e-07	175	36	5	35cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.22e-07	179	36	5	c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCell	URO-Myeloid-pDC\|URO / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.68e-07	184	36	5	0edb5dd003c2bca0b9e3ec18d03610d68bd52538
ToppCell	Leuk-UTI-Other-RBC\|Leuk-UTI / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.79e-07	185	36	5	5b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCell	Healthy_donor-pDC\|Healthy_donor / disease group, cell group and cell class (v2)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.79e-07	185	36	5	7fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCell	Leuk-UTI-Other\|Leuk-UTI / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.79e-07	185	36	5	895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCell	Bac-SEP-Myeloid-pDC\|Bac-SEP / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.79e-07	185	36	5	3de50b2042f22b0fb62ff12c76d85cc67649a0bd
ToppCell	ICU-NoSEP-Myeloid-pDC\|ICU-NoSEP / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.79e-07	185	36	5	7564a47df4a4e3af30d40aa0f48bd9d9c82358ae
ToppCell	healthy_donor-Lymphocytic-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	916f2aeea4989ba7a29e071e348a51010f010223
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	b70cd94c651b56dcf2e55554533a5f1130845390
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	31df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCell	Multiple_Sclerosis-Myeloid-pDC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	330a4f669adea91ff9f2dff2de2210f5e3401e19
ToppCell	COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease group, lineage and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	3db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	b95be984e308d4f9061274a35995ec558d434e74
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	8f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCell	healthy_donor-Lymphocytic-Dendritic-pDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	45f66619e45d590c7365a51782d4ac46b7d31fde
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.89e-07	186	36	5	95c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCell	IIH-pDC-\|IIH / Condition, Cell_class and T cell subcluster	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.99e-07	187	36	5	ad87b146ea8dd9f695e722f8f0e8e1057c7f3167
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.99e-07	187	36	5	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	IIH-pDC\|IIH / Condition, Cell_class and T cell subcluster	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.99e-07	187	36	5	5e59e9153a18bcfb5c8dc94599080216661de7ce
ToppCell	Leuk-UTI-Myeloid-pDC\|Leuk-UTI / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.99e-07	187	36	5	e3035b1f65ab12b8f01799b8e5d6633b9b584a06
ToppCell	control-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	3.99e-07	187	36	5	c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell	3'_v3-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.10e-07	188	36	5	239a2162a21d3339da7c1884ab76286346fbf97f
ToppCell	COVID-19_Severe-pDC\|World / disease group, cell group and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.10e-07	188	36	5	4c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.21e-07	189	36	5	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	Int-URO-Myeloid-pDC\|Int-URO / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.21e-07	189	36	5	37aee7a0acd5fd5dd62f22608d72ff8afe210e5c
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	adffa93635da10251f28b2089fd96b189775c8b4
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	6892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLNK IRF8 CCDC50 PRR7 PHACTR1	4.32e-07	190	36	5	60bb6aaea9691d07295f61c14d1650f5041a0f9c
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	9a91bf1ea105029e6412d0d9060bca325299ce26
ToppCell	MS-pDC\|MS / Condition, Cell_class and T cell subcluster	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	f41d7ab7d7fbcd73fddb6c3533c6a3e642e3d07f
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	39c8ddc2639bf3e986dae11fbae61a735614b604
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	a95aea3aa707fc4574810706341a5f32b3d00209
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	18dfa84c62dcf081ce9958a71e76a394ec0968e4
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / disease group, cell group and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	c5ab6b7492fb86aff3d2af3eb671c9f985ae4aeb
ToppCell	COVID_vent-Lymphocytic-B_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 ZBTB10 CCDC50 PHACTR1	4.32e-07	190	36	5	40b5e9e8f8fd8d84cb5b43e67b49267082348e9f
ToppCell	MS-pDC-\|MS / Condition, Cell_class and T cell subcluster	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	f56ec302d556ace4f7609017a35c311cf43aa8a5
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	2c1c079fd411c03bc3f383aa927eea9446716960
ToppCell	severe-B_naive\|World / disease stage, cell group and cell class	BLNK IRF8 ZBTB10 TXNIP PHACTR1	4.32e-07	190	36	5	8dfe067d75573289299a5fba42b6c9b26e5fb430
ToppCell	COVID_vent-Lymphocytic-B_cell-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 ZBTB10 CCDC50 PHACTR1	4.32e-07	190	36	5	a37a32dc1b931562a6660074e19d5598efc65284
ToppCell	Control\|World / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	015a2703618710fd4a74f687f8b2bada586d99f4
ToppCell	myeloid-pDC\|World / Lineage and Cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.32e-07	190	36	5	88c42779ce2f817d28e672d83f3f1158581edf73
ToppCell	Control-Myeloid-pDC\|Control / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.43e-07	191	36	5	473f904fe244d919ce561139591a2be12cc9fa6b
ToppCell	(01)_Dendritic_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.43e-07	191	36	5	1f4c8078e1a6cd14937c714330af608caced2acf
ToppCell	BLOOD--(3)_DC_(cDC+pDC)\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.55e-07	192	36	5	e290c55a1321e9e577f49e8ba20501b2c8150044
ToppCell	VE-pDC-\|VE / Condition, Cell_class and T cell subcluster	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.67e-07	193	36	5	583724de588fcde3aeda056138c522dc0225a387
ToppCell	control-pDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.67e-07	193	36	5	30a6559c9a9e8941861cb259b4836acccc427e68
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLNK IRF8 ZBTB10 CCDC50 PHACTR1	4.67e-07	193	36	5	ac227ddabfb3f021b1b39dba73f898517cd5a58e
ToppCell	COVID_non-vent-Lymphocytic-B_cell-\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 ZBTB10 TXNIP CCDC50	4.67e-07	193	36	5	91955c3773c9729a96e82f240f06b072367970d9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BLNK IRF8 ZBTB10 CCDC50 PHACTR1	4.67e-07	193	36	5	f4135615ee0118eec9e221becdd67888e0c2a112
ToppCell	COVID_non-vent-Lymphocytic-B_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 ZBTB10 TXNIP CCDC50	4.67e-07	193	36	5	32d139f922cd19adc1cc1e0e9a828115be9945d6
ToppCell	VE-pDC\|VE / Condition, Cell_class and T cell subcluster	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.67e-07	193	36	5	bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.79e-07	194	36	5	74545942aded51a0f4ee96054b4ce12c4d99a8a0
ToppCell	Control-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.79e-07	194	36	5	5f95a5a35f73222dbe2ca52cc580f4774f641403
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 ZBTB10 TXNIP PHACTR1	4.79e-07	194	36	5	82753b90ca3b563275c41b6040ebbcd99b185e24
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.79e-07	194	36	5	c25fc353001cdf9fcd772da5a254c857e555eab8
ToppCell	COVID-19-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	4.91e-07	195	36	5	4a7c080230ce6a79335ecbeadecb0177b2c13625
ToppCell	myeloid-pro-pDC\|World / Lineage and Cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	5.16e-07	197	36	5	8918ee006b16f6b86ed33ce1dd5c0f01f51f88f5
ToppCell	mild-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	5.16e-07	197	36	5	0cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell	severe-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	5.29e-07	198	36	5	3c4820a8391088682fb3e47b914f872533bae227
ToppCell	severe-pDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK IRF8 CCDC50 EPHB1 PHACTR1	5.29e-07	198	36	5	22da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCell	Sepsis-URO-Others\|URO / Disease, condition lineage and cell class	BLNK IRF8 CCDC50 PAK4 PHACTR1	5.29e-07	198	36	5	6caab5266da666cfbe92ac1ace26ad2004e5aa09
ToppCell	Sepsis-URO-Others-RBC\|URO / Disease, condition lineage and cell class	BLNK IRF8 CCDC50 PAK4 PHACTR1	5.29e-07	198	36	5	d35e9d0952b3f7cd5d0d1a69bad2ae81af8eed50
ToppCell	Sigmoid-Dendritic_cell-cDC1\|Sigmoid / Region, Cell class and subclass	EPHB3 SCARF1 IRF8 ROBO1 RAB11FIP4	5.56e-07	200	36	5	3523ec986e8c9e176e08836c974b1de8b56d8b16
ToppCell	severe-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK IRF8 ZBTB10 CCDC50 PHACTR1	5.56e-07	200	36	5	0e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B-B_naive\|COVID-19_Severe / Disease, condition lineage and cell class	BLNK IRF8 ZBTB10 TXNIP PHACTR1	5.56e-07	200	36	5	5ba9c541fa356d34f392a63274dcd7bfb844cbb6
ToppCell	Sigmoid-(5)_Dendritic_cell-(51)_cDC1\|Sigmoid / shred on region, Cell_type, and subtype	EPHB3 SCARF1 IRF8 ROBO1 RAB11FIP4	5.56e-07	200	36	5	4ce0a2238c90622e41fd86ac4b7d82adf4af2c3b
ToppCell	MS-IIF-Lymphocyte-B\|IIF / Disease, condition lineage and cell class	BLNK IRF8 TXNIP CCDC50 PHACTR1	5.56e-07	200	36	5	a0f3362b7ddfc122e30e75fb541bb0b7d0321c72
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-pDC\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BLNK IRF8 PDCD1 EPHB1	3.54e-06	129	36	4	454bae525f6db3d0dd6347d2a2c3ea9dda9cd212
ToppCell	Int-URO-Other\|Int-URO / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1	6.61e-06	151	36	4	ea5f25842e621be41a6491c9959d419d9cc7ebd6
ToppCell	Int-URO-Other-RBC\|Int-URO / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 EPHB1	6.61e-06	151	36	4	0344d482f1c55c9eaa15beb8d6bac1c6cdca21b3
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BLNK IRF8 PDCD1 EPHB1	6.96e-06	153	36	4	c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	BLNK IRF8 CCDC50 EPHB1	7.51e-06	156	36	4	19472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	BLNK IRF8 CCDC50 EPHB1	7.90e-06	158	36	4	2af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCell	COVID_non-vent-Lymphocytic-Dendritic-pDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 CCDC50 EPHB1	8.30e-06	160	36	4	61f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell	URO-Other\|URO / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 PHACTR1	8.30e-06	160	36	4	b0923e6bacfaba8ca40aa5706bf270eea0938b0a
ToppCell	URO-Other-RBC\|URO / Disease, Lineage and Cell Type	BLNK IRF8 CCDC50 PHACTR1	8.30e-06	160	36	4	558f3b0719e2461a69e1b93b08e21675e8d07a5a
ToppCell	COVID_non-vent-Lymphocytic-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	BLNK IRF8 CCDC50 EPHB1	8.30e-06	160	36	4	34b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell	LPS-IL1RA-Myeloid-Dendritic_cells-pDC\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BLNK IRF8 PDCD1 EPHB1	8.30e-06	160	36	4	dee756a2dc9725520d439e7273c489c2284015d8
ToppCell	LAM-Lymphoid-pDC\|LAM / Condition, Lineage and Cell class	BLNK IRF8 CCDC50 EPHB1	8.51e-06	161	36	4	bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BLNK IRF8 CCDC50 EPHB1	8.72e-06	162	36	4	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK IRF8 PRR7 PHACTR1	8.72e-06	162	36	4	28b3a6ae5519a267eefb70436d3190a387d027b9
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BLNK IRF8 CCDC50 PHACTR1	8.72e-06	162	36	4	f12c08d0d4406f9560ecfc3bc2ff38c3bc58f184
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BLNK IRF8 CCDC50 EPHB1	9.37e-06	165	36	4	e2a70dd5870fe8708bf630ed3e6eb3f295df0cdf
ToppCell	Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, Lineage and Cell Type	CCDC50 UBR7 EPHB1 PHACTR1	9.37e-06	165	36	4	8728f927502e56f2768b4224e9111939d3d7815a
ToppCell	10x5'-Liver-Myeloid_Dendritic-pDC\|Liver / Manually curated celltypes from each tissue	BLNK IRF8 CCDC50 EPHB1	9.60e-06	166	36	4	24dfa9f3e0842f9ab8350bf6a52ae0d10f2a0c44
ToppCell	10x5'v1-week_12-13-Myeloid_DC-DC-pDC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	BLNK IRF8 CCDC50 EPHB1	9.60e-06	166	36	4	9fa90d9d484563d44738bb2c6eb0775dffc4d549
ToppCell	367C-Myeloid-Dendritic-pDC\|367C / Donor, Lineage, Cell class and subclass (all cells)	BLNK IRF8 CCDC50 EPHB1	9.83e-06	167	36	4	650de8cd5df070639b8aa292aacead739cfdb02c
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	BLNK IRF8 CCDC50 EPHB1	9.83e-06	167	36	4	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	BLNK IRF8 CCDC50 PHACTR1	1.01e-05	168	36	4	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	10x5'-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	BLNK IRF8 CCDC50 EPHB1	1.01e-05	168	36	4	90f713dae3fcbd6ca801a019e3861c263ff3366b
ToppCell	B_cells-pDCs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	BLNK IRF8 CCDC50 EPHB1	1.01e-05	168	36	4	dc8f94424f60ab56facdcffa969e7f3466ee1b6e
Disease	Diffuse Large B-Cell Lymphoma	IRF8 TXNIP KMT2D	4.19e-05	55	36	3	C0079744
Disease	colon cancer (implicated_via_orthology)	NANOGP8 NANOG	7.90e-05	11	36	2	DOID:219 (implicated_via_orthology)
Disease	stomach cancer (is_marker_for)	PDCD1 KMT2D EPHB1	6.93e-04	142	36	3	DOID:10534 (is_marker_for)
Disease	COVID-19 symptoms measurement	DPP9 MUC5AC	8.40e-04	35	36	2	EFO_0600019
Disease	Multiple Sclerosis	IRF8 PDCD1	1.39e-03	45	36	2	C0026769
Disease	Multiple Sclerosis, Acute Fulminating	IRF8 PDCD1	1.39e-03	45	36	2	C0751324
Disease	idiopathic pulmonary fibrosis	DPP9 MUC5AC	2.21e-03	57	36	2	EFO_0000768
Disease	urate measurement, spine bone mineral density	PAPPA2 ROBO1	2.29e-03	58	36	2	EFO_0004531, EFO_0007701
Disease	pre-eclampsia (is_marker_for)	ROBO1 PDCD1	2.29e-03	58	36	2	DOID:10591 (is_marker_for)
Disease	multiple myeloma (is_implicated_in)	IRF8 ROBO1	2.37e-03	59	36	2	DOID:9538 (is_implicated_in)
Disease	idiopathic dilated cardiomyopathy	FAM120B PHACTR1	2.45e-03	60	36	2	EFO_0009094
Disease	systemic lupus erythematosus (is_implicated_in)	IRF8 PDCD1	2.61e-03	62	36	2	DOID:9074 (is_implicated_in)
Disease	lung carcinoma	CCDC50 TNFRSF19 AK9 EPHB1	2.74e-03	482	36	4	EFO_0001071
Disease	interstitial lung disease	DPP9 MUC5AC	3.04e-03	67	36	2	EFO_0004244
Disease	mean arterial pressure	ZBTB10 ROBO1 TOP3A PHACTR1	3.10e-03	499	36	4	EFO_0006340

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPPPIMTDGEDADYT	CCDC50	266	Q8IVM0
PQPTPDGEYVAVEMP	CFAP46	1261	Q8IYW2
PPEGPQELYTDSPME	RAB11FIP4	146	Q86YS3
LNLYTPPETPMEPDE	KAT6B	1271	Q8WYB5
AIEQDYRLPPPMDCP	EPHB1	836	P54762
QPASPAEEDKMPPYD	PRKCSH	346	P14314
EPPVPCVPEQTEYAT	PDCD1	236	Q15116
EPPPDQVFRMFPDIC	IRF8	396	Q02556
EETEMPEPLAPESYP	FRYL	2601	O94915
ESSPMPVICGPEENY	NANOG	21	Q9H9S0
VEQDYRLPPPMDCPT	EPHB3	851	P54753
MDDPTDQCQDPVPEP	MUC5AC	241	P98088
MCPEAQLPPVYPVAS	IQGAP3	401	Q86VI3
CAPPAEPPMDYEDDF	MTMR4	1056	Q9NYA4
EMEPVPMPRDPCSYE	PHACTR1	196	Q9C0D0
PMPRDPCSYEVLQPS	PHACTR1	201	Q9C0D0
PCYEEAVLMAEPPPP	PRR7	151	Q8TB68
EPPPPVFEGMYECTN	PAPPA2	1596	Q9BXP8
LDPPPPYEAVVSQMD	FAM189A2	191	Q15884
ECNEPKGDPEMAPIY	HECTD1	506	Q9ULT8
MPAEENADDSYEPPP	BLNK	86	Q8WV28
MEAASCPPDYVPPEI	DPP9	596	Q86TI2
PVYTDSEPRQEVPMC	FAM120B	366	Q96EK7
SEPRQEVPMCSDPEP	FAM120B	371	Q96EK7
EVPMCSDPEPRQEVP	FAM120B	376	Q96EK7
IEMVDGEPPYFNEPP	PAK4	506	O96013
LIPVDPQYCPPMFLD	PIAS2	556	O75928
EFPEDSYPDVPEMEP	AK9	816	Q5TCS8
PSEAVPQDKVCYPPE	PRDM14	6	Q9GZV8
ESSPMPVICGPEENY	NANOGP8	21	Q6NSW7
PAYCVPPQEGMVPVA	SCARF1	536	Q14162
MDQAPSPAVCPQAPY	STAT5A	721	P42229
VDESYDQEMPCPVPP	ROBO1	1206	Q9Y6N7
DIYPAMPEPIRKCPQ	TOP3A	646	Q13472
QDMECVPCGDPPPPY	TNFRSF19	131	Q9NS68
YPDPEDEIPDEMIQC	UBR7	141	Q8N806
PSPPSEVKMEPYECP	ZNF526	186	Q8TF50
LEDCSVMQPPVAYPE	ZBTB10	596	Q96DT7
DLNIPDTPEAPPCYM	TXNIP	321	Q9H3M7
DTPEAPPCYMDVIPE	TXNIP	326	Q9H3M7
DPEELAPVTPMEVYP	KMT2D	1156	O14686