Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K9 acetyltransferase activity	KAT2B KAT2A	2.57e-05	3	59	2	GO:0043992
GeneOntologyMolecularFunction	pyrimidine ribonucleotide binding	UGP2 HSP90AA1	8.53e-05	5	59	2	GO:0032557
GeneOntologyCellularComponent	secretory granule lumen	A2M VWF VPS13A DNAJC3 DYNC1H1 CAP1 HSP90AA1	4.86e-05	325	62	7	GO:0034774
GeneOntologyCellularComponent	cytoplasmic vesicle lumen	A2M VWF VPS13A DNAJC3 DYNC1H1 CAP1 HSP90AA1	5.36e-05	330	62	7	GO:0060205
GeneOntologyCellularComponent	vesicle lumen	A2M VWF VPS13A DNAJC3 DYNC1H1 CAP1 HSP90AA1	5.56e-05	332	62	7	GO:0031983
GeneOntologyCellularComponent	lysosome	ATXN3L TOM1L1 UBXN6 VPS13A OCRL DNAJC3 DYNC1H1 CAP1 HSP90AA1	6.11e-04	811	62	9	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	ATXN3L TOM1L1 UBXN6 VPS13A OCRL DNAJC3 DYNC1H1 CAP1 HSP90AA1	6.11e-04	811	62	9	GO:0000323
GeneOntologyCellularComponent	ATAC complex	KAT2B KAT2A	7.70e-04	14	62	2	GO:0140672
Domain	PCAF_N	KAT2B KAT2A	9.81e-06	2	59	2	IPR009464
Domain	Hist_acetylase_PCAF	KAT2B KAT2A	9.81e-06	2	59	2	IPR016376
Domain	PCAF_N	KAT2B KAT2A	9.81e-06	2	59	2	PF06466
Domain	NfI_DNAbd_pre-N	NFIA NFIX	5.86e-05	4	59	2	PF10524
Domain	CTF_NFI	NFIA NFIX	5.86e-05	4	59	2	PF00859
Domain	CTF_NFI_1	NFIA NFIX	5.86e-05	4	59	2	PS00349
Domain	CTF/NFI	NFIA NFIX	5.86e-05	4	59	2	IPR000647
Domain	CTF_NFI_2	NFIA NFIX	5.86e-05	4	59	2	PS51080
Domain	CTF/NFI_DNA-bd_N	NFIA NFIX	5.86e-05	4	59	2	IPR019548
Domain	CTF/NFI_DNA-bd_CS	NFIA NFIX	5.86e-05	4	59	2	IPR019739
Domain	CTF/NFI_DNA-bd-dom	NFIA NFIX	5.86e-05	4	59	2	IPR020604
Domain	MAD_homology1_Dwarfin-type	NFIA NFIX	6.34e-04	12	59	2	IPR003619
Domain	DWA	NFIA NFIX	6.34e-04	12	59	2	SM00523
Domain	MH1	NFIA NFIX	6.34e-04	12	59	2	PF03165
Domain	HATPase_c	MORC1 HSP90AA1	1.45e-03	18	59	2	SM00387
Domain	HATPase_c	MORC1 HSP90AA1	1.62e-03	19	59	2	PF02518
Domain	Myosin-like_IQ_dom	MYH4 ASPM	1.62e-03	19	59	2	IPR027401
Domain	-	MYH4 ASPM	1.62e-03	19	59	2	4.10.270.10
Domain	-	MORC1 HSP90AA1	1.80e-03	20	59	2	3.30.565.10
Domain	HATPase_C	MORC1 HSP90AA1	1.98e-03	21	59	2	IPR003594
Domain	IQ	MYH4 LRRIQ3 ASPM	2.14e-03	81	59	3	SM00015
Domain	Acetyltransf_1	KAT2B KAT2A	2.38e-03	23	59	2	PF00583
Domain	GNAT	KAT2B KAT2A	2.81e-03	25	59	2	PS51186
Domain	GNAT_dom	KAT2B KAT2A	2.81e-03	25	59	2	IPR000182
Domain	IQ_motif_EF-hand-BS	MYH4 LRRIQ3 ASPM	2.89e-03	90	59	3	IPR000048
Domain	Bromodomain_CS	KAT2B KAT2A	3.04e-03	26	59	2	IPR018359
Domain	IQ	MYH4 LRRIQ3 ASPM	3.18e-03	93	59	3	PS50096
Domain	Ribosomal_S5_D2-typ_fold	LONP1 HSP90AA1	5.16e-03	34	59	2	IPR020568
Domain	BROMODOMAIN_1	KAT2B KAT2A	6.09e-03	37	59	2	PS00633
Domain	Bromodomain	KAT2B KAT2A	6.41e-03	38	59	2	PF00439
Domain	-	KAT2B KAT2A	7.08e-03	40	59	2	3.40.630.30
Pubmed	Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus.	KAT2B KAT2A	3.13e-06	2	62	2	15502373
Pubmed	Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis.	KAT2B KAT2A	3.13e-06	2	62	2	11027331
Pubmed	Divergent functions of histone acetyltransferases KAT2A and KAT2B in keratinocyte self-renewal and differentiation.	KAT2B KAT2A	3.13e-06	2	62	2	37259855
Pubmed	Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5.	KAT2B KAT2A	3.13e-06	2	62	2	29555684
Pubmed	Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.	KAT2B KAT2A	3.13e-06	2	62	2	34270849
Pubmed	Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.	KAT2B KAT2A	3.13e-06	2	62	2	25269644
Pubmed	Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells.	KAT2B KAT2A	3.13e-06	2	62	2	28678170
Pubmed	GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action.	KAT2B KAT2A	9.37e-06	3	62	2	25426559
Pubmed	Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation.	CFLAR STAMBPL1	9.37e-06	3	62	2	31817770
Pubmed	Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells.	CFLAR HSP90AA1	9.37e-06	3	62	2	23256568
Pubmed	Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication.	KAT2B KAT2A	9.37e-06	3	62	2	11956210
Pubmed	Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.	NFIA NFIX	9.37e-06	3	62	2	31128945
Pubmed	Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.	KAT2B KAT2A	9.37e-06	3	62	2	12374802
Pubmed	Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.	KAT2B KAT2A	9.37e-06	3	62	2	18250157
Pubmed	KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.	KAT2B KAT2A	9.37e-06	3	62	2	27796307
Pubmed	Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.	KAT2B KAT2A	9.37e-06	3	62	2	29174768
Pubmed	In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5.	KAT2B KAT2A	9.37e-06	3	62	2	33894414
Pubmed	Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes.	KAT2B KAT2A	1.87e-05	4	62	2	14612453
Pubmed	Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice.	NFIA NFIX	1.87e-05	4	62	2	28295292
Pubmed	Gene regulatory networks controlling vertebrate retinal regeneration.	NFIA NFIX	1.87e-05	4	62	2	33004674
Pubmed	NFIA and GATA3 are crucial regulators of embryonic articular cartilage differentiation.	NFIA NFIX	1.87e-05	4	62	2	29247144
Pubmed	Nuclear factor one transcription factors as epigenetic regulators in cancer.	NFIA NFIX	1.87e-05	4	62	2	28076901
Pubmed	Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.	KAT2B KAT2A	1.87e-05	4	62	2	17301242
Pubmed	Transcription factor NF 1 expression in involuting mammary gland.	NFIA NFIX	1.87e-05	4	62	2	10959417
Pubmed	Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.	NFIA NFIX	1.87e-05	4	62	2	7590749
Pubmed	Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice.	VWF NFIX	1.87e-05	4	62	2	20431063
Pubmed	The transcriptional co-activator PCAF regulates cdk2 activity.	KAT2B KAT2A	1.87e-05	4	62	2	19773423
Pubmed	Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cells.	NFIA NFIX	1.87e-05	4	62	2	9052991
Pubmed	Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton.	KAT2B KAT2A	1.87e-05	4	62	2	18430026
Pubmed	The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.	KAT2B KAT2A	1.87e-05	4	62	2	10022868
Pubmed	P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein.	KAT2B KAT2A	1.87e-05	4	62	2	12878208
Pubmed	Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development.	NFIA NFIX	1.87e-05	4	62	2	9056636
Pubmed	Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor Nuclear Factor One.	NFIA NFIX	1.87e-05	4	62	2	12568726
Pubmed	The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.	KAT2A HSP90AA1	3.12e-05	5	62	2	23022381
Pubmed	Regulation of insulin gene transcription by multiple histone acetyltransferases.	KAT2B KAT2A	3.12e-05	5	62	2	21774670
Pubmed	Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis.	KAT2B KAT2A	3.12e-05	5	62	2	25071153
Pubmed	Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.	KAT2B KAT2A	3.12e-05	5	62	2	21131905
Pubmed	Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.	KAT2B KAT2A	3.12e-05	5	62	2	10747963
Pubmed	Identification and mapping of human histone acetylation modifier gene homologues.	KAT2B KAT2A	3.12e-05	5	62	2	9722949
Pubmed	Control of neurogenic competence in mammalian hypothalamic tanycytes.	NFIA NFIX	3.12e-05	5	62	2	34049878
Pubmed	Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.	KAT2B KAT2A	3.12e-05	5	62	2	35053209
Pubmed	Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation.	KAT2B KAT2A	3.12e-05	5	62	2	18089809
Pubmed	Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.	NFIA NFIX	3.12e-05	5	62	2	19706729
Pubmed	The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.	ATXN3L HSP90AA1	3.12e-05	5	62	2	27851749
Pubmed	p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation.	KAT2B KAT2A	3.12e-05	5	62	2	18834332
Pubmed	The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.	KAT2B KAT2A	4.67e-05	6	62	2	21987584
Pubmed	Absence of the transcription factor Nfib delays the formation of the basilar pontine and other mossy fiber nuclei.	NFIA NFIX	4.67e-05	6	62	2	19107796
Pubmed	Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications.	LONP1 HSP90AA1	4.67e-05	6	62	2	36269765
Pubmed	Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates.	KAT2B KAT2A	4.67e-05	6	62	2	9742083
Pubmed	Genetic predictors of depressive symptoms in cardiac patients.	CACNA1C VWF	4.67e-05	6	62	2	18618671
Pubmed	Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.	KAT2B KAT2A	4.67e-05	6	62	2	12887892
Pubmed	Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy.	NFIA NFIX	4.67e-05	6	62	2	21270437
Pubmed	Tat-controlled protein acetylation.	KAT2B KAT2A	4.67e-05	6	62	2	12154097
Pubmed	Corepressor CtBP1 interacts with and specifically inhibits CBP activity.	KAT2B KAT2A	4.67e-05	6	62	2	16122695
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	A2M LONP1 STAMBPL1 DYNC1H1	4.75e-05	111	62	4	21163940
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	PTPN3 IGBP1 ZFAT SBF1 HSP90AA1	5.20e-05	225	62	5	25277244
Pubmed	Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.	CACNA1C SBF1 DYNC1H1	5.48e-05	41	62	3	19343720
Pubmed	Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.	KAT2B KAT2A	6.53e-05	7	62	2	15009097
Pubmed	The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.	KAT2B KAT2A	6.53e-05	7	62	2	14767476
Pubmed	Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.	CACNA1C LRRIQ3	6.53e-05	7	62	2	21057379
Pubmed	The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation.	KAT2B ERCC6	6.53e-05	7	62	2	23667505
Pubmed	Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice.	TBC1D32 MYH4	6.53e-05	7	62	2	12176734
Pubmed	Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum.	SEC63 DNAJC3	6.53e-05	7	62	2	26085089
Pubmed	NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression.	NFIA NFIX	6.53e-05	7	62	2	10762365
Pubmed	TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.	NFIA NFIX	6.53e-05	7	62	2	25220407
Pubmed	A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.	VPS13A HSP90AA1	6.53e-05	7	62	2	27742708
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PTPN3 LONP1 IGBP1 POTEI DNAJC3 DYNC1H1 HSP90AA1	7.13e-05	573	62	7	28330616
Pubmed	H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.	KAT2B KAT2A	8.69e-05	8	62	2	28300060
Pubmed	Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX.	NFIA NFIX	8.69e-05	8	62	2	25960350
Pubmed	A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.	KAT2B KAT2A	8.69e-05	8	62	2	8684459
Pubmed	RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.	A2M POTEI HSP90AA1	9.96e-05	50	62	3	30413534
Pubmed	AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.	KAT2B KAT2A	1.12e-04	9	62	2	14752096
Pubmed	Posttranslational modifications of HIV-1 integrase by various cellular proteins during viral replication.	RAD18 KAT2A	1.12e-04	9	62	2	23863879
Pubmed	USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.	KAT2A HSP90AA1	1.12e-04	9	62	2	22542455
Pubmed	Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.	KAT2B KAT2A	1.12e-04	9	62	2	21596989
Pubmed	UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair.	KAT2B KAT2A	1.12e-04	9	62	2	28854355
Pubmed	Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.	KAT2B ERCC6	1.12e-04	9	62	2	23555303
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	LONP1 ERCC6 SBF1 ASPM EIF5B OCRL DYNC1H1 CAP1 HSP90AA1 NMD3	1.31e-04	1353	62	10	29467282
Pubmed	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.	IGBP1 UBXN6 DYNC1H1 HSP90AA1	1.34e-04	145	62	4	23349634
Pubmed	Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.	DYNC1H1 HSP90AA1	1.39e-04	10	62	2	19826009
Pubmed	GCN5 and p300 share essential functions during early embryogenesis.	KAT2B KAT2A	1.39e-04	10	62	2	15937931
Pubmed	Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.	KAT2B KAT2A	1.39e-04	10	62	2	11017084
Pubmed	Nfix regulates fetal-specific transcription in developing skeletal muscle.	NFIA NFIX	1.70e-04	11	62	2	20178747
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	KAT2B KAT2A	1.70e-04	11	62	2	24051374
Pubmed	A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.	NFIA NFIX	1.70e-04	11	62	2	22925353
Pubmed	The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes.	KAT2B KAT2A	1.70e-04	11	62	2	19936620
Pubmed	SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.	KAT2B KAT2A	1.70e-04	11	62	2	22055187
Pubmed	Acetylation of HIV-1 integrase by p300 regulates viral integration.	KAT2B KAT2A	1.70e-04	11	62	2	16096645
Pubmed	An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation.	DYNC1H1 HSP90AA1	2.04e-04	12	62	2	11867214
Pubmed	Chromatin dynamics associated with HIV-1 Tat-activated transcription.	KAT2B KAT2A	2.04e-04	12	62	2	19716452
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	CCDC83 CCDC30 TOM1L1 UGP2 GXYLT1 ADAM28 CC2D2B	2.16e-04	686	62	7	29987050
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CACNA1C MYH4 VPS13A UGP2 ASPM EIF5B KAT2A POTEI DNAJC3 HSP90AA1	2.19e-04	1442	62	10	35575683
Pubmed	Two-marker association tests yield new disease associations for coronary artery disease and hypertension.	ZFAT TTC41P	2.41e-04	13	62	2	21626137
Pubmed	Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules.	NFIA NFIX	2.41e-04	13	62	2	17553984
Pubmed	Transcriptional regulation of Nfix by NFIB drives astrocytic maturation within the developing spinal cord.	NFIA NFIX	2.41e-04	13	62	2	29106906
Pubmed	The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.	KAT2B KAT2A	2.41e-04	13	62	2	20562830
Pubmed	Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.	KAT2B KAT2A	3.23e-04	15	62	2	12601814
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ATXN3L KAT2B TRMT10A RAD18 POP4 VPS13A ASPM MX1 HSP90AA1	3.39e-04	1242	62	9	30973865
Pubmed	Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.	NFIA NFIX	3.69e-04	16	62	2	10087299
Pubmed	Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.	DYNC1H1 HSP90AA1	4.18e-04	17	62	2	20395553
Cytoband	12p13.3	CACNA1C VWF	7.86e-04	30	63	2	12p13.3
Cytoband	Xp22.2	ATXN3L MOSPD2	1.40e-03	40	63	2	Xp22.2
Cytoband	1p34.2	CCDC30 CAP1	2.82e-03	57	63	2	1p34.2
Cytoband	Ensembl 112 genes in cytogenetic band chr1p31	TYW3 LRRIQ3 NFIA	3.67e-03	224	63	3	chr1p31
Cytoband	1p31.1	TYW3 LRRIQ3	4.33e-03	71	63	2	1p31.1
GeneFamily	ATAC complex	KAT2B KAT2A	3.13e-04	13	37	2	1058
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	KAT2B KAT2A	5.44e-04	17	37	2	1059
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT2B KAT2A	5.44e-04	17	37	2	486
GeneFamily	GCN5 related N-acetyltransferases	KAT2B KAT2A	1.09e-03	24	37	2	1134
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	SEC63 DNAJC3	4.51e-03	49	37	2	584
GeneFamily	Ankyrin repeat domain containing	ANKAR ANKRD12 POTEI	1.32e-02	242	37	3	403
Coexpression	ZAMORA_NOS2_TARGETS_DN	PCYT1A LONP1 VWF NFIA DYNC1H1	1.61e-06	82	63	5	M1638
Coexpression	ZAMORA_NOS2_TARGETS_DN	PCYT1A LONP1 VWF NFIA DYNC1H1	2.42e-06	89	63	5	MM690
ToppCell	390C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF677 LONP1 ZFAT TOM1L1 VPS13A GXYLT1	2.05e-07	179	63	6	3edcd1356e49b1f5514c585861999e079ca5e579
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	CFLAR VPS13A ASPM EIF5B ANKRD12	7.72e-06	192	63	5	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M TBC1D32 VPS13A ANKRD12 STAMBPL1	7.92e-06	193	63	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TBC1D32 TRMT10A ZFAT ZNF253 ADAM28	8.33e-06	195	63	5	1e5f1967bcc898318f4e970b844b4a944eb168e5
Drug	3-chloro-4-(chloromethyl)-2(5H)-furanone	PCYT1A MX1	7.30e-06	2	62	2	CID000115001
Drug	4-(Acetoxymethyl)-2(5H)-furanone	PCYT1A MX1	7.30e-06	2	62	2	CID000149899
Drug	4-(chloromethyl)-5-hydroxy-2(5H)-furanone	PCYT1A MX1	7.30e-06	2	62	2	CID000115229
Drug	4-chloromethyl-2(5H)-furanone	PCYT1A MX1	7.30e-06	2	62	2	CID000119362
Drug	4-(dichloromethyl)-2(5H)-furanone	PCYT1A MX1	7.30e-06	2	62	2	CID000119594
Disease	Mood Disorders	CACNA1C KAT2B VPS13A HSP90AA1	3.62e-04	168	59	4	C0525045
Disease	coagulation factor measurement	VWF ASPM	7.30e-04	20	59	2	EFO_0004634
Disease	Arthrogryposis	ERCC6 DYNC1H1	8.05e-04	21	59	2	C0003886
Disease	Primary microcephaly	TRMT10A ASPM	8.85e-04	22	59	2	C0431350
Disease	Severe Congenital Microcephaly	ERCC6 DYNC1H1	1.76e-03	31	59	2	C3853041
Disease	Lung Neoplasms	A2M IGBP1 ERCC6 ADAM28	1.96e-03	265	59	4	C0024121
Disease	Malignant neoplasm of lung	A2M IGBP1 ERCC6 ADAM28	1.99e-03	266	59	4	C0242379
Disease	Microlissencephaly	ERCC6 DYNC1H1	1.99e-03	33	59	2	C1956147

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNRYAKKLQVSRHKK	TBC1D32	711	Q96NH3
LVKLKDRKVQEHEKY	ADAM28	191	Q9UKQ2
LHKFQVKIEKEKVYV	AIFM3	151	Q96NN9
NRVLKEYKDVDKKHV	CAP1	166	Q01518
RYKERDKHKDKIQIN	ANKRD12	1026	Q6UB98
KLHIIKIVAKKYRDF	CLIC6	646	Q96NY7
EQKRRAKIQKLKYFI	CC2D2B	491	Q6DHV5
VKRNAKKQEIIKAYR	DNAJC3	401	Q13217
RIDLKTKIQKYKQSV	CFLAR	161	O15519
NLKKTIIKFQAHVRK	ASPM	1581	Q8IZT6
QEKRFIQKYHSIKKI	ASPM	3156	Q8IZT6
YQQVKTKVFQLKRKE	A2M	301	P01023
QIKTLRKKNQKYHER	CCDC83	46	Q8IWF9
KKYHIVSKAIAQRLK	MSANTD5	61	A0A3B3IT52
FNLQARKRKYFKKHE	NFIA	31	Q12857
YSLRNKEIKEAIKKH	OR6K2	291	Q8NGY2
KYRKKHKSEFQLLVD	RAD18	341	Q9NS91
KKLIERKQAQIRKVY	KAT2A	676	Q92830
ISFKRKKFFIHQRQK	PTPN3	261	P26045
QKIKYREKFTIQEHF	PCDHB1	716	Q9Y5F3
IEAIYHIEVKQKKKS	LRRC9	361	Q6ZRR7
QYEKKIKRKLQSIIY	MORC1	876	Q86VD1
RLYLQKKIIQKHFEK	ANKAR	291	Q7Z5J8
LVSRYSQKLKKKIQV	ERCC6	901	P0DP91
FNLQARKRKYFKKHE	NFIX	31	Q14938
KKLIERKQAQIRKVY	KAT2B	671	Q92831
LNGKKLVKQKEHRVY	ATXN3L	191	Q9H3M9
NEKKYHLQERVDKVK	PCYT1A	236	P49585
QAKIQRYKQKKELEH	IGBP1	156	P78318
KIYKIFIKQLAKSVR	GXYLT1	416	Q4G148
HRKYLLQEQLKIIKK	LONP1	391	P36776
KSKRKVNHRKYLQKQ	FAM181B	86	A6NEQ2
KKTIGRQHVTRKKYN	SBF1	1061	O95248
LIQEYFRKFKKRKEQ	CACNA1C	1671	Q13936
HQQKVKLQKVKYRLT	CCDC30	506	Q5VVM6
TYVQSLKRKIKQFEK	DYNC1H1	1171	Q14204
KKKNNIKLYVRRVFI	HSP90AA1	356	P07900
QLYHVTLKVTKKFRV	MEP1B	386	Q16820
RVKYHVKDQKTILDK	MOSPD2	111	Q8NHP6
LKKRISKNYNHKEIQ	TOM1L1	56	O75674
KTYKENFLKRFQLTK	USP39	431	Q53GS9
KELRVKNQYEKHKEV	EIF5B	911	O60841
VVLEYFTRHKRKEKK	POP4	56	O95707
LVDKLQTKVKAYKRQ	MYH4	1871	Q9Y623
KHQSQLRKKKYLEDI	POTEI	666	P0CG38
SYKRVLQKTKEQRKH	FAM76A	131	Q8TAV0
HSKAKYKKVQLVRLV	OCRL	306	Q01968
TKKILQKYNHCRVKI	UGP2	171	Q16851
EEKYRKIKLQNKVFQ	UBXN6	191	Q9BZV1
KKYSDVKNLIKHIRD	ZFAT	361	Q9P243
RKHRQKVKQYKELYK	VPS13A	356	Q96RL7
NFVRYVQGLKKKKVI	VWF	1396	P04275
NKYKAEILKKLEHQR	STAMBPL1	141	Q96FJ0
KKSQRKQVLKYYKQV	TTC41P	1006	Q6P2S7
RRVSNHKKYKIKTIQ	SEC63	396	Q9UGP8
NREKHIKYNETKIKY	ZNF677	566	Q86XU0
KKIHIERKPYIVKNV	ZNF253	471	O75346
KDIKKLHKQIQRCYA	TRMT10A	116	Q8TBZ6
LNTKQKLYHKKIFRT	XPO6	1006	Q96QU8
HKKLIKERSNIYGKT	ZNF382	106	Q96SR6
YIHKKKRNPEKTRAQ	TYW3	216	Q6IPR3
HKKKQQEKIIRGYEA	LRRIQ3	241	A6PVS8
YKIKTLIKKYIQRQE	MX1	196	P20591
HKILSRKIQKFENQY	MX1	426	P20591
VIQVRQKTLHKKTFY	NMD3	156	Q96D46