Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.42e-10	11	65	5	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	6.11e-10	14	65	5	GO:0003964
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-25 ERVK-9 ERVK-10	2.02e-09	37	65	6	GO:0004190
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 POLG ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.39e-09	38	65	6	GO:0034061
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-25 ERVK-9 ERVK-10	2.39e-09	38	65	6	GO:0070001
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	6.11e-09	21	65	5	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.26e-07	37	65	5	GO:0016891
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.86e-07	46	65	5	GO:0016893
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 POLG ERVK-8 ERVK-7 ERVK-10 SIRT6 ERVK-11	6.20e-07	152	65	7	GO:0016779
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 POLG CHD5 ERVK-8 CHD3 ERVK-7 ERVK-10 ERVK-11	2.09e-06	262	65	8	GO:0140097
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 HELZ2 ERVK-7 ERVK-10 ERVK-11	5.31e-06	136	65	6	GO:0004540
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	5.85e-06	79	65	5	GO:0004521
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 POLG ERVK-8 HELZ2 ERVK-7 ERVK-10 ERVK-11	9.97e-06	231	65	7	GO:0004518
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 POLG CHD5 ERVK-8 HELZ2 CHD3 ERVK-7 VARS2 ERVK-10 ERVK-11	4.16e-05	645	65	10	GO:0140640
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	8.10e-05	136	65	5	GO:0004519
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	ERVK-6 ERVK-8 HELZ2 ERVK-7 VARS2 ERVK-10 ERVK-11	4.04e-04	417	65	7	GO:0140098
GeneOntologyMolecularFunction	structural molecule activity	ERVK-6 HMCN2 NPAP1 ERVK-8 LAMA2 ERVK-7 ERVK-25 ERVK-9 ERVK-10 SSPOP	5.73e-04	891	65	10	GO:0005198
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 TRIM4 ERVK-8 CHD3 ERVK-7 ERVK-9 ERVK-10 SIRT6 ERVK-11 INS-IGF2	5.73e-04	891	65	10	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 TRIM4 ERVK-8 CHD3 ERVK-7 ERVK-9 ERVK-10 SIRT6 ERVK-11 PTGIS INS-IGF2	1.47e-03	1189	65	11	GO:0046914
GeneOntologyMolecularFunction	semaphorin receptor binding	PLXNB1 SEMA4C	2.53e-03	23	65	2	GO:0030215
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-25 ERVK-9 ERVK-10	2.72e-03	430	65	6	GO:0004175
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-6 POLG KSR2 ERVK-8 ERVK-7 ERVK-10 SIRT6 ERVK-11 ITK	3.22e-03	938	65	9	GO:0016772
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.63e-10	13	66	5	GO:0015074
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 TNKS1BP1 ERVK-7 ERVK-10 ERVK-11	2.65e-07	83	66	6	GO:0006278
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	4.43e-07	48	66	5	GO:0000731
GeneOntologyBiologicalProcess	DNA biosynthetic process	ERVK-6 POLG ERVK-8 TNKS1BP1 ERVK-7 ERVK-10 ERVK-11	6.14e-06	218	66	7	GO:0071897
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 POLG ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.25e-05	178	66	6	GO:0006261
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-9 INS-IGF2	1.59e-04	85	66	4	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-9 INS-IGF2	1.59e-04	85	66	4	GO:0000768
GeneOntologyBiologicalProcess	DNA recombination	ERVK-6 KLHDC3 ERVK-8 ERVK-7 ERVK-10 SIRT6 ERVK-11	1.71e-04	368	66	7	GO:0006310
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-9 INS-IGF2	1.90e-04	89	66	4	GO:0006949
Domain	Laminin_EGF	CELSR3 CELSR2 LAMA2 PEAR1	3.54e-06	35	56	4	PF00053
Domain	EGF_Lam	CELSR3 CELSR2 LAMA2 PEAR1	3.54e-06	35	56	4	SM00180
Domain	Laminin_EGF	CELSR3 CELSR2 LAMA2 PEAR1	4.96e-06	38	56	4	IPR002049
Domain	CHDCT2	CHD5 CHD3	2.64e-05	3	56	2	PF08074
Domain	CHDNT	CHD5 CHD3	2.64e-05	3	56	2	PF08073
Domain	DUF1086	CHD5 CHD3	2.64e-05	3	56	2	IPR009462
Domain	DUF1087	CHD5 CHD3	2.64e-05	3	56	2	IPR009463
Domain	CHD_N	CHD5 CHD3	2.64e-05	3	56	2	IPR012958
Domain	CHD_C2	CHD5 CHD3	2.64e-05	3	56	2	IPR012957
Domain	DUF1087	CHD5 CHD3	2.64e-05	3	56	2	PF06465
Domain	DUF1086	CHD5 CHD3	2.64e-05	3	56	2	PF06461
Domain	DUF1087	CHD5 CHD3	2.64e-05	3	56	2	SM01147
Domain	DUF1086	CHD5 CHD3	2.64e-05	3	56	2	SM01146
Domain	EGF_LAM_2	CELSR3 CELSR2 LAMA2	9.79e-05	30	56	3	PS50027
Domain	EGF_LAM_1	CELSR3 CELSR2 LAMA2	9.79e-05	30	56	3	PS01248
Domain	EGF_1	HMCN2 CELSR3 CELSR2 LAMA2 SSPOP PEAR1	1.12e-04	255	56	6	PS00022
Domain	EGF_2	HMCN2 CELSR3 CELSR2 LAMA2 SSPOP PEAR1	1.38e-04	265	56	6	PS01186
Domain	LAM_G_DOMAIN	CELSR3 CELSR2 LAMA2	2.00e-04	38	56	3	PS50025
Domain	Laminin_G_2	CELSR3 CELSR2 LAMA2	2.33e-04	40	56	3	PF02210
Domain	LamG	CELSR3 CELSR2 LAMA2	3.10e-04	44	56	3	SM00282
Domain	GAIN_dom_N	CELSR3 CELSR2	4.77e-04	11	56	2	IPR032471
Domain	GAIN	CELSR3 CELSR2	4.77e-04	11	56	2	PF16489
Domain	ConA-like_dom	CELSR3 CELSR2 TRIM4 NBEAL2 LAMA2	4.97e-04	219	56	5	IPR013320
Domain	-	KMT2D CHD5 CHD3	6.00e-04	55	56	3	1.10.30.10
Domain	EGF_3	HMCN2 CELSR3 CELSR2 SSPOP PEAR1	6.85e-04	235	56	5	PS50026
Domain	Laminin_G	CELSR3 CELSR2 LAMA2	7.01e-04	58	56	3	IPR001791
Domain	EGF-like_dom	HMCN2 CELSR3 CELSR2 LAMA2 PEAR1	8.88e-04	249	56	5	IPR000742
Domain	HMG_box_dom	KMT2D CHD5 CHD3	9.78e-04	65	56	3	IPR009071
Domain	Znf_FYVE_PHD	KMT2D FGD2 CHD5 CHD3	9.85e-04	147	56	4	IPR011011
Domain	EGF-like_CS	HMCN2 CELSR3 CELSR2 LAMA2 PEAR1	1.10e-03	261	56	5	IPR013032
Domain	EMI	SSPOP PEAR1	1.17e-03	17	56	2	PS51041
Domain	PHD	KMT2D CHD5 CHD3	1.48e-03	75	56	3	PF00628
Domain	Znf_PHD-finger	KMT2D CHD5 CHD3	1.72e-03	79	56	3	IPR019787
Domain	RING	KMT2D TRIM4 CHD5 CHD3 RNF43	2.17e-03	305	56	5	SM00184
Domain	-	KMT2D TRIM4 FGD2 CHD5 CHD3 RNF43	2.19e-03	449	56	6	3.30.40.10
Domain	Chromo_domain	CHD5 CHD3	2.34e-03	24	56	2	IPR023780
Domain	PHD	KMT2D CHD5 CHD3	2.42e-03	89	56	3	SM00249
Domain	Znf_RING/FYVE/PHD	KMT2D TRIM4 FGD2 CHD5 CHD3 RNF43	2.45e-03	459	56	6	IPR013083
Domain	HormR	CELSR3 CELSR2	2.53e-03	25	56	2	SM00008
Domain	Znf_PHD	KMT2D CHD5 CHD3	2.57e-03	91	56	3	IPR001965
Domain	Chromo	CHD5 CHD3	2.74e-03	26	56	2	PF00385
Domain	Znf_RING	KMT2D TRIM4 CHD5 CHD3 RNF43	2.90e-03	326	56	5	IPR001841
Domain	ZF_PHD_2	KMT2D CHD5 CHD3	2.91e-03	95	56	3	PS50016
Domain	-	CELSR3 CELSR2 LAMA2	2.91e-03	95	56	3	2.60.120.200
Domain	ZF_PHD_1	KMT2D CHD5 CHD3	3.00e-03	96	56	3	PS01359
Domain	CHROMO_1	CHD5 CHD3	3.17e-03	28	56	2	PS00598
Domain	CHROMO_2	CHD5 CHD3	3.17e-03	28	56	2	PS50013
Domain	HRM	CELSR3 CELSR2	3.17e-03	28	56	2	PF02793
Domain	ASX_HYDROXYL	HMCN2 CELSR3 CELSR2	3.36e-03	100	56	3	PS00010
Domain	Sema	PLXNB1 SEMA4C	3.88e-03	31	56	2	SM00630
Domain	Semap_dom	PLXNB1 SEMA4C	3.88e-03	31	56	2	IPR001627
Domain	Sema	PLXNB1 SEMA4C	3.88e-03	31	56	2	PF01403
Domain	SEMA	PLXNB1 SEMA4C	3.88e-03	31	56	2	PS51004
Domain	EGF-type_Asp/Asn_hydroxyl_site	HMCN2 CELSR3 CELSR2	3.96e-03	106	56	3	IPR000152
Domain	SNF2_N	CHD5 CHD3	4.13e-03	32	56	2	IPR000330
Domain	PSI	PLXNB1 SEMA4C	4.13e-03	32	56	2	PF01437
Domain	Chromodomain-like	CHD5 CHD3	4.13e-03	32	56	2	IPR016197
Domain	SNF2_N	CHD5 CHD3	4.13e-03	32	56	2	PF00176
Domain	Plexin_repeat	PLXNB1 SEMA4C	4.13e-03	32	56	2	IPR002165
Domain	Chromo/shadow_dom	CHD5 CHD3	4.39e-03	33	56	2	IPR000953
Domain	CHROMO	CHD5 CHD3	4.39e-03	33	56	2	SM00298
Domain	GPS	CELSR3 CELSR2	4.66e-03	34	56	2	SM00303
Domain	GPS	CELSR3 CELSR2	4.93e-03	35	56	2	PF01825
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 CHD3	4.93e-03	35	56	2	IPR002464
Domain	GPS	CELSR3 CELSR2	5.21e-03	36	56	2	PS50221
Domain	EGF	CELSR3 CELSR2 LAMA2 PEAR1	5.38e-03	235	56	4	SM00181
Domain	GPS	CELSR3 CELSR2	5.50e-03	37	56	2	IPR000203
Domain	DEAH_ATP_HELICASE	CHD5 CHD3	5.79e-03	38	56	2	PS00690
Domain	EGF_CA	HMCN2 CELSR3 CELSR2	5.86e-03	122	56	3	SM00179
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SCAF1 KMT2D SLC2A4RG CELSR3 CELSR2 SZT2 NBEAL2 POLG CHD5 KSR2 HELZ2 TNKS1BP1 MED13L ARRDC2 RNF43 PRRT4	3.02e-10	1105	68	16	35748872
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ERVK-11	7.11e-10	94	68	7	21542922
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9 ERVK-11	7.15e-09	3	68	3	9971820
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10	2.86e-08	4	68	3	10469592
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-25 ERVK-9 ERVK-10 ERVK-11	4.01e-08	18	68	4	18664271
Pubmed	A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.	INS-IGF2 PLXNB1 SEMA4C	1.55e-06	12	68	3	20478304
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-9	1.55e-06	12	68	3	14557543
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	CELSR3 CELSR2 SSPOP	3.20e-06	15	68	3	20473291
Pubmed	Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway.	FOXO1 SIRT6	3.77e-06	2	68	2	27457971
Pubmed	Foxo1 regulates marginal zone B-cell development.	FOXO1 CD19	3.77e-06	2	68	2	20449867
Pubmed	Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9.	CELSR3 CELSR2	3.77e-06	2	68	2	10790539
Pubmed	The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.	KMT2D CD19	3.77e-06	2	68	2	26366710
Pubmed	Sirtuin 6 affects glucose reabsorption and gluconeogenesis in type 1 diabetes via FoxO1.	FOXO1 SIRT6	3.77e-06	2	68	2	35157928
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SCAF1 CNOT11 KLLN MED4 SZT2 NPAP1 VARS2 STRA6 MED13L RUNDC1 USP19 SEMA4C	9.14e-06	1327	68	12	32694731
Pubmed	SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart.	FOXO1 SIRT6	1.13e-05	3	68	2	29319170
Pubmed	Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.	FOXO1 SIRT6	1.13e-05	3	68	2	25009184
Pubmed	Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.	POLG INS-IGF2	1.13e-05	3	68	2	21555558
Pubmed	EBF2 Links KMT2D-Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN.	KLLN KMT2D	1.13e-05	3	68	2	38015024
Pubmed	Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin.	FOXO1 INS-IGF2	1.13e-05	3	68	2	19758991
Pubmed	The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.	CELSR3 CELSR2	1.13e-05	3	68	2	11677057
Pubmed	The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.	KMT2D CHD3	1.13e-05	3	68	2	26551667
Pubmed	Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).	FOXO1 INS-IGF2	1.13e-05	3	68	2	21335550
Pubmed	Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes.	FOXO1 INS-IGF2	2.25e-05	4	68	2	36341906
Pubmed	Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription.	FOXO1 INS-IGF2	2.25e-05	4	68	2	21817126
Pubmed	The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.	CELSR3 CELSR2	2.25e-05	4	68	2	37224017
Pubmed	Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.	FOXO1 CD19	2.25e-05	4	68	2	18978794
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10	2.25e-05	4	68	2	7983737
Pubmed	Developmental expression profiles of Celsr (Flamingo) genes in the mouse.	CELSR3 CELSR2	2.25e-05	4	68	2	11850187
Pubmed	Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes.	FOXO1 INS-IGF2	2.25e-05	4	68	2	28009298
Pubmed	Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions.	HMCN2 LAMA2	2.25e-05	4	68	2	34504132
Pubmed	Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.	CELSR3 CELSR2 INS-IGF2	3.40e-05	32	68	3	23177622
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7	3.75e-05	5	68	2	12629516
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	3.75e-05	5	68	2	11401426
Pubmed	The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.	CD19 ITK	3.75e-05	5	68	2	20439541
Pubmed	CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.	FOXO1 CD19	3.75e-05	5	68	2	25630702
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2D CD19	3.75e-05	5	68	2	26744420
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-9	5.62e-05	6	68	2	15063128
Pubmed	Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.	KMT2D CD19	5.62e-05	6	68	2	26366712
Pubmed	Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6.	FOXO1 SIRT6	5.62e-05	6	68	2	23881913
Pubmed	FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.	FOXO1 SIRT6	5.62e-05	6	68	2	23974119
Pubmed	Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.	CELSR3 CELSR2	7.86e-05	7	68	2	17937400
Pubmed	Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.	FOXO1 SIRT6	7.86e-05	7	68	2	31442424
Pubmed	The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.	FOXO1 INS-IGF2	7.86e-05	7	68	2	12488434
Pubmed	The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help.	FOXO1 CD19	7.86e-05	7	68	2	28351982
Pubmed	Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.	LAMA2 INS-IGF2	1.05e-04	8	68	2	10102687
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	CELSR3 CELSR2	1.34e-04	9	68	2	9693030
Pubmed	The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.	FOXO1 CD19	1.34e-04	9	68	2	31767615
Pubmed	Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.	PLXNB1 SEMA4C	1.34e-04	9	68	2	25892012
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	UNC5A PLXNB1 SEMA4C	1.48e-04	52	68	3	26633812
Pubmed	Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.	FOXO1 CD19	1.68e-04	10	68	2	33207194
Pubmed	DBC1 is a negative regulator of SIRT1.	FOXO1 CHD3	1.68e-04	10	68	2	18235501
Pubmed	Celsr3 is required in motor neurons to steer their axons in the hindlimb.	CELSR3 CELSR2	1.68e-04	10	68	2	25108913
Pubmed	TCTP is essential for β-cell proliferation and mass expansion during development and β-cell adaptation in response to insulin resistance.	FOXO1 INS-IGF2	1.68e-04	10	68	2	24248465
Pubmed	Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.	FOXO1 FOXH1	2.05e-04	11	68	2	15084259
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	CELSR3 CELSR2	2.05e-04	11	68	2	25024228
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	CNOT11 MED4 TNKS1BP1	2.15e-04	59	68	3	28813667
Pubmed	Human Ccr4-Not complexes contain variable deadenylase subunits.	CNOT11 TNKS1BP1	2.45e-04	12	68	2	19558367
Pubmed	Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.	CELSR3 CELSR2	2.45e-04	12	68	2	11891983
Pubmed	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.	CNOT11 TNKS1BP1	2.45e-04	12	68	2	31320642
Pubmed	Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.	CELSR3 CELSR2	2.45e-04	12	68	2	20631168
Pubmed	Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.	CELSR3 CELSR2 RNF43	2.73e-04	64	68	3	24431302
Pubmed	An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.	PLXNB1 SEMA4C	2.90e-04	13	68	2	24572910
Pubmed	MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.	MED4 MED13L	2.90e-04	13	68	2	27570068
Pubmed	Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.	CELSR3 CELSR2	3.38e-04	14	68	2	39225402
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LAMA2 MED13L SSPOP	3.71e-04	71	68	3	33541421
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD5 CHD3	3.89e-04	15	68	2	35695185
Pubmed	Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.	PLXNB1 SEMA4C	3.89e-04	15	68	2	21122816
Pubmed	Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.	CELSR3 CELSR2	3.89e-04	15	68	2	25002511
Pubmed	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.	FOXO1 INS-IGF2	3.89e-04	15	68	2	27572106
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	HMCN2 LAMA2 SSPOP INS-IGF2	3.92e-04	175	68	4	28071719
Pubmed	FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression.	FOXO1 INS-IGF2	4.44e-04	16	68	2	31923647
Pubmed	Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.	FOXO1 INS-IGF2	4.44e-04	16	68	2	19635472
Pubmed	Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis.	PLXNB1 SEMA4C	4.44e-04	16	68	2	19948886
Pubmed	Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas.	FOXO1 INS-IGF2	5.03e-04	17	68	2	36529318
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD5 CHD3	5.03e-04	17	68	2	27806305
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	KLLN KLHDC3 ANXA2R LAMA2 ERVK-25 ERVK-10 SIRT6 NCKAP5L INS-IGF2	5.82e-04	1215	68	9	15146197
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CELSR3 SZT2 NBEAL2 CHD5 TNKS1BP1 PLXNB1	5.93e-04	529	68	6	14621295
Pubmed	Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.	PLXNB1 SEMA4C	6.30e-04	19	68	2	17554007
Pubmed	Transcriptional regulatory network of SOX4 during myoblast differentiation.	FOXH1 PLXNB1	6.30e-04	19	68	2	25969425
Pubmed	RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.	CNOT11 TNKS1BP1	7.00e-04	20	68	2	34887419
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	MED4 HMCN2 NBEAL2 NPAP1 ABTB1	7.15e-04	361	68	5	18976975
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SCAF1 KMT2D HELZ2 TNKS1BP1 CHD3 USP19 WDR62	7.86e-04	774	68	7	15302935
Pubmed	Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.	PLXNB1 SEMA4C	9.28e-04	23	68	2	21035938
Pubmed	Generation of functional insulin-producing cells in the gut by Foxo1 ablation.	FOXO1 INS-IGF2	9.28e-04	23	68	2	22406641
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CHD5 HELZ2 TNKS1BP1 MED13L	1.00e-03	225	68	4	12168954
Pubmed	A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.	INS-IGF2 PLXNB1	1.01e-03	24	68	2	28893946
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	HELZ2 TNKS1BP1 SEMA4C	1.07e-03	102	68	3	11214970
Pubmed	Holoprosencephaly Overview	KMT2D FOXH1	1.10e-03	25	68	2	20301702
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	CELSR3 CELSR2	1.19e-03	26	68	2	37228654
Pubmed	Embryonic Steroids Control Developmental Programming of Energy Balance.	FOXO1 INS-IGF2	1.28e-03	27	68	2	34599818
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SCAF1 HMCN2 TRIM4 CHD5 CHD3 NCKAP5L RNF43 WDR62	1.47e-03	1116	68	8	31753913
Pubmed	Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.	FOXO1 INS-IGF2	1.48e-03	29	68	2	25784544
Pubmed	BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.	FOXO1 INS-IGF2	1.48e-03	29	68	2	17339028
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	FOXO1 CELSR3 CELSR2 PLXNB1	1.50e-03	251	68	4	29031500
Pubmed	Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.	FOXO1 INS-IGF2	1.58e-03	30	68	2	22980982
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	PPP1R10 KMT2D	1.69e-03	31	68	2	20516061
Pubmed	The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.	MED4 MED13L	1.69e-03	31	68	2	23322298
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	KMT2D MED4 CHD3 MED13L	1.91e-03	268	68	4	33640491
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	CELSR3 CELSR2	1.91e-03	33	68	2	25713288
Interaction	TOP3B interactions	SCAF1 CNOT11 KMT2D SLC2A4RG CELSR3 CELSR2 SZT2 NBEAL2 POLG CHD5 KSR2 HELZ2 TNKS1BP1 MED13L ARRDC2 RNF43 PRRT4	1.35e-06	1470	62	17	int:TOP3B
Cytoband	3p21.31	CELSR3 NBEAL2 ALS2CL PLXNB1 USP19	4.14e-07	100	68	5	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	CELSR3 NBEAL2 ALS2CL PLXNB1 USP19	1.09e-04	316	68	5	chr3p21
Cytoband	Ensembl 112 genes in cytogenetic band chr13q14	FOXO1 MED4 MLNR FAM124A	4.86e-04	244	68	4	chr13q14
Cytoband	12q13.12	KMT2D NCKAP5L	1.47e-03	38	68	2	12q13.12
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR3 CELSR2	1.66e-05	3	43	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR3 CELSR2	1.66e-05	3	43	2	1189
GeneFamily	PHD finger proteins\|NuRD complex	CHD5 CHD3	3.59e-04	12	43	2	1305
GeneFamily	Immunoglobulin like domain containing	HMCN2 CD19 ICAM5 SEMA4C	1.12e-03	193	43	4	594
GeneFamily	PHD finger proteins	KMT2D CHD5 CHD3	1.27e-03	90	43	3	88
GeneFamily	Cyclins\|Mediator complex	MED4 MED13L	2.78e-03	33	43	2	1061
GeneFamily	Forkhead boxes	FOXO1 FOXH1	4.69e-03	43	43	2	508
Coexpression	GSE39916_B_CELL_SPLEEN_VS_PLASMA_CELL_BONE_MARROW_UP	FOXO1 KMT2D BEND5 CHD3 NCKAP5L ALS2CL	6.97e-06	199	61	6	M9269
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	FOXO1 HELZ2 CHD3 ALS2CL ITK	7.64e-06	198	61	5	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	Adult-Immune-enucleated_erythrocyte-D175\|Adult / Lineage, Cell type, age group and donor	HMCN2 CELSR2 CHD5 SLC4A10	5.63e-05	152	61	4	530d5427d8617dcb223d807b73abee0ef89285f3
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR3 POU5F2 KSR2 ALS2CL	5.63e-05	152	61	4	b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCell	facs-Marrow-KLS-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ICAM5 SSPOP PTGIS ITK	5.92e-05	154	61	4	37765512dfae557b9f6eb30a29463b93682a4404
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGD2 AARD STRA6 GRIN3B	8.10e-05	167	61	4	8b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCell	droplet-Skin-nan-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSPOP PTGIS ITK PEAR1	1.04e-04	178	61	4	12d5c6be6cfbf733e3cb02780606b3725eda7d2b
ToppCell	droplet-Skin-nan-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSPOP PTGIS ITK PEAR1	1.04e-04	178	61	4	e0769ad06f92423a3cb6c78a61da3ba5bd9b4eae
ToppCell	droplet-Skin-nan-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSPOP PTGIS ITK PEAR1	1.04e-04	178	61	4	11c2ce093b7538518c8d4497dc5b0b4da22bf1a8
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD19 FGD2 BEND5 SLC4A10	1.11e-04	181	61	4	ce0e39114bf3bcbcce0fd4c0d70bedadd0853e1d
ToppCell	NS-critical-d_0-4-Lymphoid-Treg\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FOXO1 ZNF775 SLC4A10 ITK	1.15e-04	183	61	4	f478dfa231fc1b12ead0183cc9d22077cdf43d1f
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-Naive_B_cells\|GI_large-bowel / Manually curated celltypes from each tissue	CD19 FGD2 BEND5 ARRDC2	1.20e-04	185	61	4	1c99373c123b5e0de40b47d9d885974a747b9839
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-B_cells-Pro-B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXO1 PATL2 CD19 ANXA2R	1.23e-04	186	61	4	4a5264e32ba004ed58dc4102d84e4bc4dbbe1440
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-B_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXO1 PATL2 CD19 ANXA2R	1.23e-04	186	61	4	528ee88f6e27863c7bcdffd4416cbbd83fc65e9d
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FOXO1 HMCN2 LAMA2 PTGIS	1.25e-04	187	61	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ICAM5 CHD5 CHD3	1.25e-04	187	61	4	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ICAM5 CHD5 CHD3	1.25e-04	187	61	4	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ICAM5 CHD5 CHD3	1.25e-04	187	61	4	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	UNC5A CELSR3 KSR2 SLC4A10	1.33e-04	190	61	4	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXO1 CD19 FGD2 BEND5	1.39e-04	192	61	4	9b8191e66626919cad2c63349c8ef61e9792fcf5
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Naive_B_cells\|bone_marrow / Manually curated celltypes from each tissue	CD19 FGD2 BEND5 ARRDC2	1.39e-04	192	61	4	fa99243ff028498c6a67d207a93e02c48e69cd42
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CELSR3 CHD5 KSR2 SLC4A10	1.39e-04	192	61	4	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	CV-Severe-6\|Severe / Virus stimulation, Condition and Cluster	PATL2 MED4 CHD3 ITK	1.44e-04	194	61	4	d33be6ed1de907aeea0c2dce09796556b8efdd4e
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FOXO1 HMCN2 LAMA2 PTGIS	1.47e-04	195	61	4	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	wk_08-11-Hematologic_Lymphocytic\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CD19 ANXA2R SLC4A10 ITK	1.47e-04	195	61	4	7f6ff1180c0be199c63dd049700d62dbc792b347
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	FOXO1 CHD3 ALS2CL ITK	1.47e-04	195	61	4	22191d361af136942508f1553ff41a626ed982ad
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	PATL2 LAMA2 LINC00612 CHD3	1.47e-04	195	61	4	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PATL2 LAMA2 LINC00612 CHD3	1.50e-04	196	61	4	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PATL2 LAMA2 LINC00612 CHD3	1.50e-04	196	61	4	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PATL2 LAMA2 LINC00612 CHD3	1.50e-04	196	61	4	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PATL2 LAMA2 LINC00612 CHD3	1.50e-04	196	61	4	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PATL2 ICAM5 RNF43 PLXNB1	1.53e-04	197	61	4	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	healthy_donor-Lymphocytic-T_cell-CD4+_Naive_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	FOXO1 CHD3 ALS2CL ITK	1.53e-04	197	61	4	cf72160f03105876641fa6fdc7405e339eb084c7
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	ICAM5 NBEAL2 RNF43 PLXNB1	1.56e-04	198	61	4	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAMA2 STRA6 PTGIS PEAR1	1.59e-04	199	61	4	dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell	Sigmoid-T_cell-Tfh\|Sigmoid / Region, Cell class and subclass	FOXO1 HELZ2 TNKS1BP1 ITK	1.59e-04	199	61	4	fa9404a021a015d1d571c324780b6eef2da47c4c
ToppCell	Transverse-T_cell-Tfh\|Transverse / Region, Cell class and subclass	ZNF775 NBEAL2 NCKAP5L ITK	1.59e-04	199	61	4	cbef8f95edf2e86e16c448a76068d7ed8f6b7748
ToppCell	Transverse-(1)_T_cell-(16)_Tfh\|Transverse / shred on region, Cell_type, and subtype	ZNF775 NBEAL2 NCKAP5L ITK	1.59e-04	199	61	4	aa31e26d48066f865ca33251a33a28934c0a7a44
ToppCell	Sigmoid-(1)_T_cell-(16)_Tfh\|Sigmoid / shred on region, Cell_type, and subtype	FOXO1 HELZ2 TNKS1BP1 ITK	1.59e-04	199	61	4	a61bf52d2d359746433623ee00337124f1f84f61
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAMA2 STRA6 PTGIS PEAR1	1.59e-04	199	61	4	c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PPP1R10 VARS2 RNF43 PLXNB1	1.62e-04	200	61	4	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ICAM5 NBEAL2 RNF43 PLXNB1	1.62e-04	200	61	4	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	HELZ2 CHD3 ALS2CL ITK	1.62e-04	200	61	4	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	FOXO1 PATL2 HELZ2 PEAR1	1.62e-04	200	61	4	5c638c80661017c85f9390f1b398ac7728c8f001
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	FOXO1 PATL2 HELZ2 PEAR1	1.62e-04	200	61	4	604a88633d4162337e394155c7346dbdef8b9f5a
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-MAIT\|ICU-NoSEP / Disease, condition lineage and cell class	ZNF775 ANXA2R SLC4A10 ZNF74	1.62e-04	200	61	4	4f03b5f4110ed1637ffe17cb6ff309265a3af9a8
Drug	Tiletamine hydrochloride; Up 200; 15.4uM; PC3; HT_HG-U133A	CELSR3 POLG SIRT6 STRA6 ALS2CL PTGIS WDR62	9.59e-07	197	61	7	7311_UP
Disease	hepatocyte growth factor-like protein measurement	CELSR3 ALS2CL USP19	6.09e-05	38	59	3	EFO_0008154
Disease	progeria (implicated_via_orthology)	POLG SIRT6	1.09e-04	8	59	2	DOID:3911 (implicated_via_orthology)
Disease	Mental Retardation, Psychosocial	SLC4A10 STRA6 MED13L WDR62	1.76e-04	139	59	4	C0025363
Disease	Profound Mental Retardation	SLC4A10 STRA6 MED13L WDR62	1.76e-04	139	59	4	C0020796
Disease	Mental deficiency	SLC4A10 STRA6 MED13L WDR62	1.76e-04	139	59	4	C0917816
Disease	Microphthalmos	KMT2D STRA6	2.14e-04	11	59	2	C0026010
Disease	gastric adenocarcinoma (is_implicated_in)	KMT2D RNF43	2.14e-04	11	59	2	DOID:3717 (is_implicated_in)
Disease	Sezary Syndrome	KMT2D CHD3	1.34e-03	27	59	2	C0036920
Disease	Intellectual Disability	SLC4A10 CHD3 STRA6 MED13L WDR62	1.99e-03	447	59	5	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
CAIDPRGPPRLELSW	nan	206	A8MWP4
PESPPRAPRDWGALL	BEND5	51	Q7L4P6
PDPSDPWGRECLRLL	ALS2CL	36	Q60I27
PGRAELWFPPRPACD	AARD	21	Q4LEZ3
VWVPGPIDDRCPAKP	ERVK-8	131	Q902F8
VWVPGPIDDRCPAKP	ERVK-9	131	Q9UKH3
PLPEIPNGEWLCPRC	CHD5	446	Q8TDI0
RVWCPESEAHIPLPP	CELSR2	91	Q9HCU4
PIVSSEDRGPWPLPL	ANXA2R	26	Q3ZCQ2
DWRLGALPERPEAPP	ARRDC2	326	Q8TBH0
IPDACLFRPSWAIPP	MED13L	966	Q71F56
TPPLPSSERPLWPLC	FOXH1	206	O75593
LWPLCPLPGPTRVEG	FOXH1	216	O75593
DPLLLCSPATPWRPP	NCKAP5L	201	Q9HCH0
PCPARGTPKPQVTWR	HMCN2	1271	Q8NDA2
PVCPPEPTPWIRTHL	KSR2	181	Q6VAB6
PLLPNPCSPISEGRW	FAM124A	251	Q86V42
TCRTPALPGLPEDPW	PLXNB1	1336	O43157
PSPGVRCSREGIPWP	ICAM5	696	Q9UMF0
PFSLLPSEPCERPWE	PEAR1	46	Q5VY43
LCPRLDDPAWTPGPS	POLG	576	P54098
RPGICPGPDVWRIPL	POU5F2	51	Q8N7G0
PSPLRNIPPFEGCIW	LAMA2	2671	P24043
PACWLPPILTERGER	KLLN	146	B2CW77
VCAPLTWVPGDPRRP	MED4	161	Q9NPJ6
VWVPGPIDDRCPAKP	ERVK-7	891	P63135
LEIEEGWKYRPPPPC	PATL2	316	C9JE40
DPDFEPLPRPRSCTW	FOXO1	11	Q12778
VWVPGPIDDRCPAKP	ERVK-25	131	P61570
VWVPGPIDDRCPAKP	ERVK-6	131	Q69384
WVPGPIDDRCPAKPE	ERVK-7	21	P61567
KDRPEIWEGEPPCLP	CD19	161	P15391
IWEGEPPCLPPRDSL	CD19	166	P15391
PLPDIPNGEWLCPRC	CHD3	486	Q12873
RPLPWKSTVPPCIGV	C17orf80	581	Q9BSJ5
SGPRGWCVIPRDDPL	FGD2	561	Q7Z6J4
WLDCPPTPVLPEGRR	KLHDC3	226	Q9BQ90
LGAPREWLSTLPPPR	CELSR3	3146	Q9NYQ7
PDLPTCALPRPWSVP	HELZ2	496	Q9BYK8
PSPEVSCCGLWPRRP	INS-IGF2	181	F8WCM5
EPPWPALPPCDERRC	MLNR	16	O43193
PLPPTPEDNRRPLWE	ITK	156	Q08881
PREGPVWLCSYGRPP	GRIN3B	956	O60391
PLPPCEAVRWAPVGA	RUNDC1	31	Q96C34
AEELWQRLPPRPGCP	VARS2	861	Q5ST30
PWPLEPEGPRVTRVE	SZT2	446	Q5T011
WRLSPLCPEPGDLPH	SSPOP	1176	A2VEC9
RPGEPPLDLGSIPWL	PTGIS	26	Q16647
WSRGPAPDPCLVPLA	NBEAL2	236	Q6ZNJ1
WLCLTPRQPLEPHPP	RNF43	726	Q68DV7
RPCPEPDEKLWDPVG	SEMA4C	721	Q9C0C4
WDGPRVLERALPPLP	SIRT6	276	Q8N6T7
SLPLLWDRGELPPPA	NPAP1	341	Q9NZP6
WDRGELPPPAKLPCL	NPAP1	346	Q9NZP6
LWPDCVRGRPGLPSP	STRA6	76	Q9BX79
PELRGDLWELPFPCP	ABTB1	251	Q969K4
SPWPRTLGPAPALCV	LINC00612	26	Q8N6U2
RPPPPLHICEDELAW	CNOT11	286	Q9UKZ1
LPRVWAAPDRGPVPS	USP19	926	O94966
EPGLEPWKEALVRPP	SLC2A4RG	131	Q9NR83
PPDTWVPSRLDLRPG	SCAF1	106	Q9H7N4
VLPPGEWDPSIRIEP	SLC4A10	426	Q6U841
VLEPGRDSPPSWRPQ	TNKS1BP1	1496	Q9C0C2
IWVPGPIDDRCPAKP	ERVK-10	891	P10266
ACRLQPGPPRGRPEW	ZNF775	236	Q96BV0
PTPPLQLRWDRDEGP	nan	261	A8MX80
VWVPGPTDDRCPAKP	ERVK-11	891	Q9UQG0
ALLPWRCPPGAPCLA	PRRT4	386	C9JH25
RPPEGIPPAEVEWLR	UNC5A	171	Q6ZN44
RLPPCIPGAWLTPAL	TRPM1	1041	Q7Z4N2
AEETLEAWRPPPPCL	WDR62	1156	O43379
VPGAEWLPPTRGLLC	nan	86	Q6ZR54
PWSMQREVPRGPCPE	ZNF74	101	Q16587
PVPPGLCGRHWEPLR	TRIM4	81	Q9C037
EEKVPWVCPRPLVLP	PPP1R10	456	Q96QC0
TPPLQLRWDRDEGPP	nan	261	A6NL46
ELPFDWPRCPVVSPG	KMT2D	86	O14686