Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN1	1.09e-04	4	90	2	GO:0098855
Domain	SPAN-X_fam	SPANXD SPANXC SPANXA1	1.27e-05	10	90	3	IPR010007
Domain	SPAN-X	SPANXD SPANXC SPANXA1	1.27e-05	10	90	3	PF07458
Domain	Ion_trans_N	HCN4 HCN1	1.37e-04	4	90	2	PF08412
Domain	Ion_trans_N	HCN4 HCN1	1.37e-04	4	90	2	IPR013621
Domain	UBIQUITIN_1	USP14 UBQLN2 USP48	7.47e-04	37	90	3	PS00299
Domain	Peptidase_M28	CPQ NCLN	1.47e-03	12	90	2	IPR007484
Domain	Peptidase_M28	CPQ NCLN	1.47e-03	12	90	2	PF04389
Domain	CUB	DCBLD1 CSMD2 OVCH1	1.70e-03	49	90	3	PF00431
Domain	CUB	DCBLD1 CSMD2 OVCH1	1.80e-03	50	90	3	SM00042
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN1	2.01e-03	14	90	2	IPR003938
Domain	-	DCBLD1 CSMD2 OVCH1	2.02e-03	52	90	3	2.60.120.290
Domain	CUB	DCBLD1 CSMD2 OVCH1	2.13e-03	53	90	3	PS01180
Domain	UBIQUITIN_2	USP14 UBQLN2 USP48	2.25e-03	54	90	3	PS50053
Domain	CUB_dom	DCBLD1 CSMD2 OVCH1	2.62e-03	57	90	3	IPR000859
Domain	cNMP-bd_CS	HCN4 HCN1	2.64e-03	16	90	2	IPR018488
Domain	Ubiquitin_dom	USP14 UBQLN2 USP48	2.76e-03	58	90	3	IPR000626
Pubmed	The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion.	SPANXD SPANXC SPANXA1	1.73e-08	3	91	3	26895102
Pubmed	Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.	SPANXD SPANXC SPANXA1	1.73e-07	5	91	3	16251457
Pubmed	SPANX gene variation in fertile and infertile males.	SPANXD SPANXC SPANXA1	1.73e-07	5	91	3	20073942
Pubmed	Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa.	SPANXD SPANXC SPANXA1	1.73e-07	5	91	3	11133693
Pubmed	Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines.	SPANXD SPANXC SPANXA1	1.73e-07	5	91	3	14734458
Pubmed	The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.	SPANXD SPANXC SPANXA1	1.73e-07	5	91	3	12758128
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	CXCR5 CDKL5 ERBB4 TNR	1.31e-06	31	91	4	27798109
Pubmed	Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.	SPANXD SPANXC SPANXA1	2.05e-06	10	91	3	17012309
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	6.77e-06	2	91	2	17548059
Pubmed	Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.	HCN4 HCN1	6.77e-06	2	91	2	21456027
Pubmed	Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.	HCN4 HCN1	6.77e-06	2	91	2	11675786
Pubmed	IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in glioma.	IL10 JAK2	6.77e-06	2	91	2	27765933
Pubmed	Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation.	IL10 JAK2	6.77e-06	2	91	2	22323454
Pubmed	CTp11, a novel member of the family of human cancer/testis antigens.	SPANXC SPANXA1	6.77e-06	2	91	2	10626816
Pubmed	Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	HCN4 HCN1	6.77e-06	2	91	2	19135060
Pubmed	U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction.	U2AF2 DDX39B	6.77e-06	2	91	2	9242493
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DCAF1 DNAJC13 MROH7 ITPRID2 DOCK6 CNOT1	1.58e-05	202	91	6	33005030
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	NRDE2 ZC3H14 DNAJC13 HYOU1 SPTAN1 U2AF2 PATL1 SYAP1 CNOT1 DDX39B	2.03e-05	724	91	10	36232890
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN1	2.03e-05	3	91	2	22652004
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN1	2.03e-05	3	91	2	21187420
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN1	2.03e-05	3	91	2	21945247
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	2.03e-05	3	91	2	22006928
Pubmed	Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes.	JAK2 TFEB	2.03e-05	3	91	2	28424277
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN1	2.03e-05	3	91	2	33181864
Pubmed	Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.	PI4KB ZFYVE26	2.03e-05	3	91	2	25365221
Pubmed	Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.	IL10 ERBB4	2.03e-05	3	91	2	23033483
Pubmed	Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation.	JAK2 ERBB4	2.03e-05	3	91	2	18653779
Pubmed	Expression of SpanX proteins in normal testes and in testicular germ cell tumours.	SPANXC SPANXA1	2.03e-05	3	91	2	16390498
Pubmed	EP3 activation facilitates bladder excitability via HCN channels on ICCs.	HCN4 HCN1	2.03e-05	3	91	2	28131828
Pubmed	CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.	IL10 CXCR5	2.03e-05	3	91	2	17015714
Pubmed	Calycosin-7-O-β-D-glucoside attenuates myocardial ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway via the regulation of IL-10 secretion in mice.	IL10 JAK2	2.03e-05	3	91	2	31712941
Pubmed	Functional expression of the human HCN3 channel.	HCN4 HCN1	4.05e-05	4	91	2	16043489
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN4 HCN1	4.05e-05	4	91	2	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	4.05e-05	4	91	2	12928435
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN4 HCN1	4.05e-05	4	91	2	20140458
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN4 HCN1	4.05e-05	4	91	2	22748890
Pubmed	Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells.	IL10 JAK2	4.05e-05	4	91	2	19361784
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN4 HCN1	4.05e-05	4	91	2	9630217
Pubmed	Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.	APBB2 APLP2	4.05e-05	4	91	2	8855266
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN4 HCN1	4.05e-05	4	91	2	21615589
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MON2 CDKL5 ERBB4 HK2 HCN4 GLG1 HCN1 SPTAN1 NCLN CNOT1 DDX39B DCLK1	4.19e-05	1139	91	12	36417873
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	MON2 TBC1D15 DNAJC13 PI4KB APBB2 HS1BP3 DOCK6 C19orf25	5.46e-05	504	91	8	34432599
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	ZC3H14 HYOU1 GLG1 SEC24A KIF14 U2AF2 APLP2 HS1BP3 PATL1 ITPRID2 SYAP1	6.50e-05	1007	91	11	34597346
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN4 HCN1	6.74e-05	5	91	2	15564593
Pubmed	Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcγR or complement.	IL10 CXCR5	6.74e-05	5	91	2	23749374
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN4 HCN1	6.74e-05	5	91	2	34429357
Pubmed	IL-10-producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction.	IL10 CXCR5	6.74e-05	5	91	2	31591231
Pubmed	Heparin-binding EGF-like growth factor shows transient left-right asymmetrical expression in mouse myotome pairs.	ERBB4 DNAH11	6.74e-05	5	91	2	15533812
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TFEB ERBB4 PI4KB SEC24A SPTAN1 KIF14 FOXO4 ITPRID2 DOCK6 DCLK1	8.65e-05	861	91	10	36931259
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MON2 DNAJC13 HYOU1 SEC24A SPTAN1 KIF14 APLP2 PFDN4 ITPRID2 CNOT1 C19orf25	9.34e-05	1049	91	11	27880917
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	JAK2 ERBB4 RIN2 APBB2	9.44e-05	90	91	4	16273093
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MON2 USP14 TBC1D15 HK2 HYOU1 SPTAN1 KIF14 ITPRID2 EXTL3 NCLN CNOT1 JMY C19orf25	9.46e-05	1440	91	13	30833792
Pubmed	Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.	HCN4 HCN1	1.01e-04	6	91	2	25761792
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	MON2 USP14 TBC1D15 UBQLN2 HK2 HYOU1 EIF4A3 SEC24A SPTAN1 PFDN4 USP48 CNOT1 DDX39B	1.05e-04	1455	91	13	22863883
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	DCAF1 HYOU1 HCN4 SPTAN1 GNPTAB ZFP1 TMEM266 FOXO4 USP48 TSEN15 MAGEC2 C19orf25	1.39e-04	1293	91	12	15342556
Pubmed	Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.	NRDE2 EIF4A3	1.41e-04	7	91	2	30538148
Pubmed	CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.	DNAH17 DNAH11	1.41e-04	7	91	2	33139725
Pubmed	Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies.	IL10 ERBB4	1.41e-04	7	91	2	16465591
Pubmed	Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.	HCN4 HCN1	1.41e-04	7	91	2	19421833
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH17 DNAH11	1.41e-04	7	91	2	31178125
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	NRDE2 EIF4A3 U2AF2 DDX39B	1.65e-04	104	91	4	31365120
Pubmed	Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.	IL10 JAK2	2.41e-04	9	91	2	11114383
Pubmed	Elongin B/C recruitment regulates substrate binding by CIS.	JAK2 CCNC	2.41e-04	9	91	2	18508766
Pubmed	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	HCN4 HCN1 APLP2	2.42e-04	46	91	3	37207277
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	PNMA1 UBQLN2 TRIM54 ITPRID2	2.68e-04	118	91	4	21078624
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	HCN4 HCN1	3.01e-04	10	91	2	16382102
Pubmed	Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.	APBB2 APLP2	3.01e-04	10	91	2	16407979
Pubmed	Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.	IL10 FOXO4	3.01e-04	10	91	2	23444404
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TBC1D15 HK2 HYOU1 EIF4A3 SPTAN1 KIF14 U2AF2 APLP2 NCLN SYAP1 CNOT1 DDX39B	3.39e-04	1425	91	12	30948266
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZC3H14 TBC1D15 HYOU1 EIF4A3 KIF14 U2AF2 ITPRID2 NCLN CNOT1 DDX39B	3.49e-04	1024	91	10	24711643
Pubmed	Identification of Osr2 Transcriptional Target Genes in Palate Development.	BMP5 SEMA3E	3.67e-04	11	91	2	28731788
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	USP14 TBC1D15 UBQLN2 HYOU1 GLG1 APLP2 NCLN	4.20e-04	516	91	7	36610398
Pubmed	Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.	EIF4A3 DDX39B	4.39e-04	12	91	2	18974867
Pubmed	Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.	HCN4 HCN1	4.39e-04	12	91	2	17482496
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	MON2 DCAF1 LGMN TBC1D15 UBQLN2 HK2 GLG1 DDX39B	4.44e-04	686	91	8	28380382
Pubmed	The protein interaction landscape of the human CMGC kinase group.	TFEB CDKL5 EIF4A3 SPTAN1 U2AF2 PFDN4 DDX39B CCNC	4.84e-04	695	91	8	23602568
Pubmed	Human mRNA export machinery recruited to the 5' end of mRNA.	EIF4A3 DDX39B	5.18e-04	13	91	2	17190602
Pubmed	Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease.	IL10 CXCR5	5.18e-04	13	91	2	28978474
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TBC1D15 UBQLN2 HK2 HYOU1 SEC24A U2AF2 PFDN4 ITPRID2 NCLN SYAP1 DDX39B C19orf25	5.23e-04	1496	91	12	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NRDE2 ZC3H14 GGNBP2 ING3 GLG1 SLC39A11 TMEM266 KIF14 APLP2 ITPRID2 DCLK1 CCNC	5.26e-04	1497	91	12	31527615
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	NRDE2 DNAJC13 EIF4A3 SPTAN1 U2AF2 APLP2 HS1BP3 DOCK6 CNOT1 DDX39B	5.36e-04	1082	91	10	38697112
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	USP14 ZC3H14 TBC1D15 HK2 HYOU1 SPTAN1 DDX39B	5.38e-04	538	91	7	28524877
Pubmed	Sequence and expression of murine type I hair keratins mHa2 and mHa3.	KIF9 KIF14	6.04e-04	14	91	2	7514534
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH17 DNAH11	6.04e-04	14	91	2	9373155
Pubmed	Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.	PATL1 CNOT1	6.04e-04	14	91	2	20584987
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	HCN4 HCN1	6.04e-04	14	91	2	29107716
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	USP14 ZC3H14 TBC1D15 SPTAN1 KIF14 SYAP1 CNOT1	6.07e-04	549	91	7	38280479
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MON2 USP14 GGNBP2 HK2 ING3 SUV39H1 GNPTAB APLP2 PATL1 CNOT1 CCNC	6.93e-04	1327	91	11	32694731
Pubmed	Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.	HCN4 HCN1	6.95e-04	15	91	2	21147989
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	USP14 UBQLN2 DDX39B	7.04e-04	66	91	3	24811749
Pubmed	14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.	DCAF1 EIF4A3 U2AF2	7.04e-04	66	91	3	23472066
Pubmed	Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.	APOA5 DNAH17	7.93e-04	16	91	2	24886709
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DNAJC13 EIF4A3 SPTAN1 U2AF2 USP48 CNOT1 DDX39B	8.54e-04	582	91	7	20467437
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DCAF1 EIF4A3 ZFP1 KIF14 PFDN4 PATL1 CNOT1 TSEN15 DDX39B C19orf25	8.84e-04	1155	91	10	20360068
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	MON2 DCAF1 HYOU1 EXTL3 NCLN	8.91e-04	282	91	5	35007762
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP14 USP48	8.98e-04	17	91	2	23287719
Pubmed	Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.	IL10 JAK2	8.98e-04	17	91	2	19861958
Pubmed	Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse.	STRA8 CNOT1	1.01e-03	18	91	2	22448252
Pubmed	Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.	EIF4A3 DCLK1	1.01e-03	18	91	2	27618312
Pubmed	Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.	HCN4 HCN1	1.01e-03	18	91	2	27180262
Cytoband	Xq27.1	SPANXD SPANXC SPANXA1	5.02e-06	17	91	3	Xq27.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq27	SPANXD SPANXC SPANXA1 MAGEC2	3.38e-05	91	91	4	chrXq27
Cytoband	Ensembl 112 genes in cytogenetic band chr1q25	AXDND1 TNR TSEN15 KLHL20	3.53e-04	167	91	4	chr1q25
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	4.48e-04	10	58	2	250
GeneFamily	Dyneins, axonemal	DNAH17 DNAH11	1.33e-03	17	58	2	536
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	BMP5 SLC39A11 APBB2 DCBLD1 NLGN1 DOCK6	2.08e-06	185	90	6	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	IL10 LGMN ERBB4 RHOBTB1 ABCA6	2.39e-05	169	90	5	241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA6 NLGN1 OVCH1 ATP8B2 DCLK1	2.60e-05	172	90	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	DNAJC13 HYOU1 GLG1 GNPTAB DDX39B	2.99e-05	177	90	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	BAL-Control-Myeloid-Macrophage\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IL10 TFEB LGMN SLC39A11 DCLK1	3.50e-05	183	90	5	8e9d45c96b44558158e3d59613f64a73d5390c19
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IL10 TFEB LGMN SLC39A11 DCLK1	3.50e-05	183	90	5	0408d991ddb639594b45d5cb2432dd29289167b1
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IL10 TFEB LGMN SLC39A11 DCLK1	3.50e-05	183	90	5	79f05b8a967124d831b0baef137e30659f5917a7
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IL10 TFEB LGMN SLC39A11 DCLK1	3.59e-05	184	90	5	92202e1cd0bba1ce4b061ebcb8a2af5bb590542a
ToppCell	BAL-Control-Myeloid-Macrophage\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IL10 TFEB LGMN SLC39A11 DCLK1	3.59e-05	184	90	5	7331535d469453a5264dcb0270a97f63d3b55201
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IL10 TFEB LGMN SLC39A11 DCLK1	3.59e-05	184	90	5	337e38a6b2b6770cc992d88b006829f194841b10
ToppCell	Control-Myeloid-transitional_Macro\|Control / Disease group,lineage and cell class （2021.01.30）	IL10 TFEB LGMN SLC39A11 DCLK1	4.29e-05	191	90	5	3ed0b1ff628a165e3c92c2e493206015f57dccfe
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP5 HK2 ABCA6 CPQ TRIM54	4.74e-05	195	90	5	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	BMP5 ABCA6 APBB2 CSMD2 DCLK1	4.97e-05	197	90	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA6 HCN1 PFDN4 NLGN1 DCLK1	4.97e-05	197	90	5	6806ec223e542f0475303698eb78c1cc527f5c6b
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	BMP5 ABCA6 APBB2 CSMD2 DCLK1	4.97e-05	197	90	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA6 CPQ NLGN1 DCLK1 SEMA3E	5.34e-05	200	90	5	3a164e3971bcd62b148b813171c103adb81f972e
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	2.51e-05	3	86	2	DOID:13884 (implicated_via_orthology)
Disease	anemia (phenotype), response to ribavirin	DNAH17 PFDN4	2.98e-04	9	86	2	EFO_0004272, GO_1901559
Disease	protein CREG1 measurement	LGMN GNPTAB	2.98e-04	9	86	2	EFO_0801937
Disease	liver cancer (is_marker_for)	IL10 JAK2	2.98e-04	9	86	2	DOID:3571 (is_marker_for)
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	PI4KB USP48	4.54e-04	11	86	2	DOID:0050564 (is_implicated_in)
Disease	rheumatoid arthritis, ulcerative colitis	IL10 JAK2	1.70e-03	21	86	2	EFO_0000685, EFO_0000729
Disease	Ovarian Serous Adenocarcinoma	JAK2 CDKL5	2.04e-03	23	86	2	C1335177
Disease	colorectal cancer, hormone replacement therapy	RIN2 DCBLD1 PFDN4	2.19e-03	88	86	3	EFO_0003961, MONDO_0005575
Disease	HDL cholesterol change measurement	APOA5 DOCK6	2.22e-03	24	86	2	EFO_0007805
Disease	triacylglycerol 56:4 measurement	NLGN1 MAGEC2	2.22e-03	24	86	2	EFO_0010431
Disease	West Syndrome	CDKL5 SPTAN1	2.22e-03	24	86	2	C0037769
Disease	HMG CoA reductase inhibitor use measurement	ABCA6 APOA5 DOCK6 DNAH11	2.30e-03	189	86	4	EFO_0009932
Disease	lipid measurement, lipoprotein measurement	ABCA6 APOA5 DOCK6	2.34e-03	90	86	3	EFO_0004529, EFO_0004732
Disease	omega-6 polyunsaturated fatty acid measurement	ABCA6 APOA5 DOCK6 DNAH11	2.67e-03	197	86	4	EFO_0005680

Protein segments in the cluster

Peptide	Gene	Start	Entry
MMDAEEYLVPQAFNI	ERBB4	1016	Q15303
AVVSYVVADMEEMLP	CPQ	456	Q9Y646
YLILENDMLSLVDPM	APBB2	471	Q92870
MNYPLTLEMDLENLE	CXCR5	1	P32302
MYDRNIQPTDIMASE	CSMD2	3461	Q7Z408
MDIERVNIAFNYDMP	DDX39B	351	Q13838
THMDEILLENLPYAM	ABCA6	111	Q8N139
LIYFIDDMNMPEVDL	DNAH11	2571	Q96DT5
QAIEDLVSMPDIFMD	CRAT	526	P43155
PYTMDLMEQVALRVQ	APOA5	131	Q6Q788
SNEEEEMEMAVIYLQ	CFAP91	486	Q7Z4T9
IYEEVENNMMLLGAT	ATP8B2	651	P98198
EVIPEIMQGIYMQLS	MROH7	741	Q68CQ1
PDYELLTENDMLPNM	JAK2	811	O60674
QDVVRQFMEIEPEML	NCLN	121	Q969V3
QYVQDMGQEDMLLPL	CCNC	161	P24863
CQEMYPELQITNVME	APLP2	91	Q06481
IQMMQLQSTDPYLDD	PATL1	416	Q86TB9
EQIVEMMEFLIEYGP	DCAF1	566	Q9Y4B6
LNEDPQLSEMLLYMI	KIF14	806	Q15058
VQLMEIFETEDQVYM	PSKH2	121	Q96QS6
YEAEEPVTEAEMLMI	MAGEC2	156	Q9UBF1
NTESMVELLDLYQME	JMY	351	Q8N9B5
IDRIVMQELQDMFPE	GNPTAB	961	Q3T906
MIQFYLEEVMPQAEN	IL10	86	P22301
QIPLYIDDTLTMVME	GGNBP2	21	Q9H3C7
YSTQIDEMPMNVADL	EIF4A3	396	P38919
LIEEMDVPTELYLVM	DCLK1	451	O15075
EMENQIYAIPEDIMR	HK2	106	P52789
DYLEMIEQLPMDLRD	ING3	6	Q9NXR8
DIMLADDDCLMIPYQ	PFDN4	56	Q9NQP4
ASQDRMPQDLDLDMY	FOXO4	461	P98177
EYFPDEMQEILDLMT	NRDE2	1131	Q9H7Z3
YNESFVIPEDMQMAL	KIF9	706	Q9HAQ2
ENMQIMYPAIFDQLL	MON2	1351	Q7Z3U7
ILMEQGEFLNYDIML	NLGN1	411	Q8N2Q7
NVMEPVTELMQEQSY	ITPRID2	1066	P28290
VDNFNEVLEEYPMMR	HCN4	686	Q9Y3Q4
QDMMESLFYTVIVPL	OR5H6	286	Q8NGV6
LQETEMMDPELDYTL	GLG1	866	Q92896
LIPEMDQIFTEVEMT	HYOU1	841	Q9Y4L1
VDNFNEVLEEYPMMR	HCN1	566	O60741
NFQEVMESEEFMLLP	KLHL20	196	Q9Y2M5
IQAMDEMDILQYIQD	HS1BP3	366	Q53T59
HQEDPEMLIDLMYRI	DOCK6	1571	Q96HP0
MMTLPQQLEEEFTEE	CPLANE1	1931	Q9H799
MDNMVIDESIAPLFE	DNAH17	886	Q9UFH2
VMPQAIRDMVDEYIN	EXTL3	816	O43909
LEGEMPSERQYMEEI	AXDND1	566	Q5T1B0
MLDLYNAMTNEENPE	BMP5	81	P22003
MMSIDDAYEVLNLPQ	DNAJC13	1296	O75165
LPAIYLMENVAMEEL	ENC1	241	O14682
DLITSDMADYQQPLM	DCBLD1	531	Q8N8Z6
YVEKNMLELLEEMPN	CDKL5	91	O76039
MPAEMLNYILDNVIQ	PNMA1	136	Q8ND90
AMVYVVMDDIIPEAQ	SLC39A11	301	Q8N1S5
GYMPTEMELIEISQQ	CABP2	111	Q9NPB3
MMEDAEAPGEQLYQQ	C19orf25	51	Q9UFG5
RINPLQMEEEEFMEI	SPANXA1	76	Q9NS26
RLDDVLGYINPEMQM	TFEB	166	P19484
QMLIVSDIEDVFIPM	SEC24A	566	O95486
EYSNVLQEMELPIMD	OVCH1	186	Q7RTY7
QMYPVALVMLQEDEL	SYAP1	166	Q96A49
MDADMDYERPNVETI	RHOBTB1	1	O94844
LPQLLNMYIHMDEDV	PI4KB	176	Q9UBF8
LTFDYNMQVDPVDME	SUV39H1	361	O43463
QEASFPVDEEMIMLQ	STRA8	306	Q7Z7C7
RINPLQMEEEEFMEI	SPANXC	76	Q9NY87
LPQLMEVVRSNYEAM	CNOT1	1806	A5YKK6
LMDLHPVYVESQLMD	TMEM210	96	A6NLX4
SAIQSMEEPQMALYL	TRIM54	266	Q9BYV2
TEIEYMMELLDPSLL	RIN2	716	Q8WYP3
DPSQRILYMDVMLEN	ZFP1	26	Q6P2D0
QVINMYGELIMDAVP	SENP5	586	Q96HI0
LMEIYEEINVIFMPA	TIGD1	311	Q96MW7
RINPLQMEEEEFMEI	SPANXD	76	Q9BXN6
QQQEVYGMMPRDETD	SPTAN1	1171	Q13813
LNYSPRDEEEEMMEV	TNR	806	Q92752
MSDLLSPLLYVMENE	TBC1D15	456	Q8TC07
MNMVLPEELLDDEEY	U2AF2	381	P26368
MLQQILHDMYIDPEL	SH2D4B	1	Q5SQS7
IYNQEMESMEEVILE	SEMA3E	466	O15041
MYTDIQEPMLNAAQE	UBQLN2	271	Q9UHD9
PEAIEMYIEIVMVSE	TEX15	2056	Q9BXT5
LMLDMYELCTPELQE	USP14	351	P54578
EPIADYAAMDDVMQV	USP48	1006	Q86UV5
VDEELPDYIMVMVAN	ZC3H14	26	Q6PJT7
DPSTVMNMILEAQEY	ZFYVE26	1546	Q68DK2
YLEMMELDIGDATQV	TSEN15	46	Q8WW01
LPVKLEMEMVIQQYE	TMEM266	221	Q2M3C6
IPDEQIVVMMYDDIA	LGMN	61	Q99538