Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	tRNA splicing, via endonucleolytic cleavage and ligation	RTCB DDX1	1.28e-04	13	27	2	GO:0006388
GeneOntologyBiologicalProcess	RNA splicing, via endonucleolytic cleavage and ligation	RTCB DDX1	1.49e-04	14	27	2	GO:0000394
GeneOntologyBiologicalProcess	negative regulation of B cell mediated immunity	CR1 PARP3	1.96e-04	16	27	2	GO:0002713
GeneOntologyBiologicalProcess	negative regulation of immunoglobulin mediated immune response	CR1 PARP3	1.96e-04	16	27	2	GO:0002890
GeneOntologyBiologicalProcess	negative regulation of immunoglobulin production	CR1 PARP3	3.09e-04	20	27	2	GO:0002638
GeneOntologyCellularComponent	tRNA-splicing ligase complex	RTCB DDX1	4.48e-05	8	27	2	GO:0072669
Pathway	WP_DDX1_AS_A_REGULATORY_COMPONENT_OF_THE_DROSHA_MICROPROCESSOR	DGCR8 DDX1	4.00e-05	7	20	2	M39689
Pubmed	The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1.	RTCB DDX1	5.80e-07	2	27	2	37556111
Pubmed	hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.	RTCB DDX1	5.80e-06	5	27	2	24608264
Pubmed	Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.	RTCB DDX1	1.22e-05	7	27	2	24870230
Pubmed	HSPC117 is the essential subunit of a human tRNA splicing ligase complex.	RTCB DDX1	1.22e-05	7	27	2	21311021
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BUD13 DGCR8 ZNF512 RTCB DDX1 KTN1	2.12e-05	759	27	6	35915203
Pubmed	Identification of new high affinity targets for Roquin based on structural conservation.	RTCB DDX1	3.18e-05	11	27	2	30295819
Pubmed	USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.	TRAPPC8 RTCB DDX1	3.95e-05	85	27	3	29228324
Pubmed	A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.	BUD13 ZNF512	6.06e-05	15	27	2	21386085
Pubmed	Common body mass index-associated variants confer risk of extreme obesity.	FBN2 ANO3	6.06e-05	15	27	2	19553259
Pubmed	Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.	RPL34 FLG2 RTCB DDX1	7.05e-05	289	27	4	37132043
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	BUD13 DGCR8 ZNF512 RTCB DDX1 KTN1	7.58e-05	954	27	6	36373674
Pubmed	The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance.	RTCB MBD1	8.81e-05	18	27	2	36178098
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	RPL34 RTCB DDX1 KTN1 MBD1	8.93e-05	601	27	5	33658012
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	RPL34 DGCR8 RTCB DDX1 KTN1	9.95e-05	615	27	5	31048545
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	PTRH2 RPL34 DGCR8 RTCB DDX1	1.98e-04	713	27	5	29802200
Pubmed	Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.	RTCB DDX1	2.17e-04	28	27	2	38492217
Pubmed	NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.	RPL34 DGCR8 FLG2	2.35e-04	155	27	3	33838681
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	PTRH2 RPL34 RTCB DDX1	2.98e-04	421	27	4	34650049
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	RPL34 RTCB DDX1	3.19e-04	172	27	3	26336360
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PTRH2 RPL34 ZNF276 RTCB KTN1 MBD1	3.96e-04	1294	27	6	30804502
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	RTCB DDX1	4.01e-04	38	27	2	30629181
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	PTRH2 RTCB DDX1 KTN1	5.04e-04	484	27	4	31995728
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MINAR1 TRAPPC8 ZNF512 KTN1	5.40e-04	493	27	4	15368895
Pubmed	SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.	RPL34 RTCB DDX1	6.19e-04	216	27	3	37640791
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	RPL34 RTCB DDX1	6.53e-04	220	27	3	34091597
Pubmed	Human transcription factor protein interaction networks.	RPL34 FBN2 FLG2 ZNF512 RTCB DDX1	6.70e-04	1429	27	6	35140242
Pubmed	Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.	ZNF512 KTN1 MBD1	7.24e-04	228	27	3	30471916
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PTRH2 RPL34 CR1 GVINP1 RTCB DDX1	7.26e-04	1451	27	6	30550785
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	RPL34 RTCB DDX1 KTN1	7.49e-04	538	27	4	28524877
Interaction	RPL26L1 interactions	BUD13 RPL34 DGCR8 ZNF512 RTCB DDX1	5.16e-06	431	22	6	int:RPL26L1
Cytoband	1q44	OR2L8 OR2L3	1.92e-03	110	27	2	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2L8 OR2L3	2.59e-03	128	27	2	chr1q44
GeneFamily	Olfactory receptors, family 2	OR2L8 OR2L3	5.55e-03	113	18	2	149
Coexpression	GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN	CDKL3 PTRH2 PTPN21 RTCB CYP7A1	1.35e-06	198	26	5	M5782
Coexpression	GSE13411_NAIVE_VS_IGM_MEMORY_BCELL_UP	RPL34 ZNF276 PTPN21 GVINP1	3.98e-05	196	26	4	M3239
Coexpression	GSE22886_NEUTROPHIL_VS_MONOCYTE_DN	RTCB UFC1 DDX1 KTN1	4.23e-05	199	26	4	M4467
Computational	Neighborhood of DDX5	RPL34 TRAPPC8 MBD1	1.02e-04	63	16	3	GNF2_DDX5
Disease	triglyceride measurement, metabolic syndrome	BUD13 ZNF512	2.08e-05	8	26	2	EFO_0000195, EFO_0004530
Disease	age of onset of Alzheimer disease	CR1 ANO3	3.88e-04	33	26	2	OBA_2001000
Disease	cholesteryl ester 20:4 measurement	BUD13 DGCR8	6.90e-04	44	26	2	EFO_0010348
Disease	familial hyperlipidemia	ZNF512 CYP7A1	3.93e-03	106	26	2	MONDO_0001336
Disease	Drug Use Disorders	TMPRSS7 DDX1	4.60e-03	115	26	2	C0013222
Disease	Drug Dependence	TMPRSS7 DDX1	4.60e-03	115	26	2	C1510472
Disease	Drug habituation	TMPRSS7 DDX1	4.60e-03	115	26	2	C0013170
Disease	Substance Dependence	TMPRSS7 DDX1	4.60e-03	115	26	2	C0038580
Disease	Substance Use Disorders	TMPRSS7 DDX1	4.60e-03	115	26	2	C0038586
Disease	Substance-Related Disorders	TMPRSS7 DDX1	4.60e-03	115	26	2	C0236969
Disease	Drug abuse	TMPRSS7 DDX1	4.60e-03	115	26	2	C0013146
Disease	Organic Mental Disorders, Substance-Induced	TMPRSS7 DDX1	4.60e-03	115	26	2	C0029231
Disease	Prescription Drug Abuse	TMPRSS7 DDX1	4.60e-03	115	26	2	C4316881
Disease	Substance abuse problem	TMPRSS7 DDX1	4.68e-03	116	26	2	C0740858

Protein segments in the cluster

Peptide	Gene	Start	Entry
GKKAAHMYSGAKTGL	BUD13	416	Q9BRD0
GEGSYGTVMKCKHKN	CDKL3	11	Q8IVW4
HIKRYCSDNGGEKMK	GVINP1	2161	Q7Z2Y8
GKNQKSEYVMACGKH	DGCR8	646	Q8WYQ5
RKKCYYTDGRSKSMG	ANO3	231	Q9BYT9
HMKSAEGRKKAYLTC	OR2L3	226	Q8NG85
KSAGYVIGMKCGAHH	PARP3	421	Q9Y6F1
VKGMRKAFSTCGAHL	OR5H14	231	A6NHG9
KEYCKASGSKKHRRG	FLG2	91	Q5D862
GCRATKGLMKGKHYY	DDX1	121	Q92499
KHARRKGGCDSKMAA	MBD1	266	Q9UIS9
HMKSAEGRKKAYLTC	OR2L8	226	Q8NGY9
HGFEKKAKECMAGTS	KTN1	1096	Q86UP2
SGCYATTGLKMKHLL	PTPN21	1036	Q16825
KGRSASHCVLAGMKA	CR1	1746	P17927
RKHGHVFTCKLMGKY	CYP7A1	61	P22680
HMRSTCYGGIKKGVC	FBN2	701	P35556
KKHVSRAYGGSMCAK	RPL34	71	P49207
CTSGQGKYSDRHTMK	MINAR1	491	Q9UPX6
YAAKKMGIDHKGQVC	RTCB	241	Q9Y3I0
KMGKGKVAAQCSHAA	PTRH2	76	Q9Y3E5
TAKMYRGGKICLTDH	UFC1	106	Q9Y3C8
RHMVMHSGDGTYKCK	ZNF700	211	Q9H0M5
YSITKKSMKGCEHGW	TMPRSS7	416	Q7RTY8
CTAVYRGADGMKKHI	ZNF276	441	Q8N554
CHTGKYSLSMSVRGK	TRAPPC8	861	Q9Y2L5
HCGKQLRSLAGMKYH	ZNF512	201	Q96ME7