Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.76e-16	114	80	13	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.38e-15	124	80	13	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.90e-15	137	80	13	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 ESPL1 USP17L15 USP17L13 USP17L18	3.10e-14	192	80	14	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	PRSS35 USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 ESPL1 USP17L15 USP17L13 USP17L18	4.21e-08	654	80	15	GO:0008233
GeneOntologyMolecularFunction	RS domain binding	SON SRSF12	4.37e-04	8	80	2	GO:0050733
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.48e-15	125	79	13	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	9.60e-15	144	79	13	GO:0070646
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 TSPYL5 USP17L10 USP17L19 USP17L22 WNK1 MAP3K12 USP17L15 USP17L13 USP17L18	2.54e-06	1074	79	16	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 TSPYL5 USP17L10 USP17L19 USP17L22 WNK1 USP17L15 USP17L13 USP17L18	5.64e-06	1009	79	15	GO:0070647
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription	SCAF8 WNK1	8.65e-05	4	79	2	GO:1904594
GeneOntologyBiologicalProcess	negative regulation of mRNA splicing, via spliceosome	SRSF4 SRSF6 SRSF12	1.65e-04	28	79	3	GO:0048025
GeneOntologyBiologicalProcess	negative regulation of mRNA processing	SRSF4 SRSF6 SRSF12	1.84e-04	29	79	3	GO:0050686
GeneOntologyBiologicalProcess	regulation of termination of DNA-templated transcription	SCAF8 WNK1	2.15e-04	6	79	2	GO:0031554
GeneOntologyBiologicalProcess	regulation of muscle organ development	DCANP1 FGF8 TWIST1	2.25e-04	31	79	3	GO:0048634
GeneOntologyBiologicalProcess	negative regulation of RNA splicing	SRSF4 SRSF6 SRSF12	2.72e-04	33	79	3	GO:0033119
GeneOntologyCellularComponent	RNA polymerase III transcription regulator complex	BDP1 GTF3C1	4.99e-04	9	79	2	GO:0090576
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 PHTF1 USP17L13 USP17L18	1.06e-03	1293	79	13	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 PHTF1 USP17L13 USP17L18	1.10e-03	1299	79	13	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 PHTF1 USP17L13 USP17L18	1.34e-03	1327	79	13	GO:0042175
HumanPheno	Short philtrum	FGF8 SPEN TFAP2B RAI1 MADD TWIST1 SON	2.07e-05	253	19	7	HP:0000322
HumanPheno	Generalized hirsutism	LMNB2 MBD5 SPEN TWIST1	2.76e-04	89	19	4	HP:0002230
HumanPheno	Abnormal hair morphology	SCUBE3 FGF8 LMNB2 SPIDR MBD5 KAT6B SPEN TFAP2B MED13 RAI1 MADD TWIST1 SON	2.80e-04	1424	19	13	HP:0001595
HumanPheno	Gastroesophageal reflux	FGF8 MBD5 KAT6B WNK1 SPEN RAI1 TWIST1 SON	2.92e-04	517	19	8	HP:0002020
HumanPheno	Short attention span	CABP4 FGF8 MBD5 SPEN MED13 RAI1 MADD RSRC1	2.92e-04	517	19	8	HP:0000736
HumanPheno	Abnormal nasal bridge morphology	SCUBE3 FGF8 KAT6B SPEN TFAP2B MED13 RAI1 MADD RSRC1 TWIST1 SON	3.30e-04	1029	19	11	HP:0000422
HumanPheno	Reduced attention regulation	CABP4 FGF8 MBD5 SPEN MED13 RAI1 MADD RSRC1	3.30e-04	526	19	8	HP:5200044
HumanPheno	Deviation of finger	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 MADD TWIST1	3.81e-04	537	19	8	HP:0004097
HumanPheno	Aplasia/hypoplasia involving bones of the hand	SCUBE3 LMNB2 MBD5 KAT6B TFAP2B RAI1 TWIST1 SON	3.86e-04	538	19	8	HP:0005927
HumanPheno	Long nose	SCUBE3 KAT6B TWIST1	4.29e-04	41	19	3	HP:0003189
HumanPheno	Hypermetropia	CABP4 MBD5 SPEN RAI1 MADD SON	4.50e-04	288	19	6	HP:0000540
HumanPheno	Attention deficit hyperactivity disorder	CABP4 FGF8 SPEN MED13 RAI1 MADD RSRC1	4.67e-04	413	19	7	HP:0007018
HumanPheno	Hyperactivity	CABP4 FGF8 MBD5 SPEN MED13 RAI1 MADD RSRC1	4.96e-04	558	19	8	HP:0000752
HumanPheno	Clinodactyly of the 5th finger	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1	5.18e-04	420	19	7	HP:0004209
HumanPheno	Abnormal hand morphology	SCUBE3 LMNB2 MBD5 KAT6B WNK1 SPEN TFAP2B RAI1 MADD TWIST1 SON	5.23e-04	1082	19	11	HP:0005922
HumanPheno	Clinodactyly of hands	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1	5.25e-04	421	19	7	HP:0001157
HumanPheno	Deviation of the 5th finger	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1	5.25e-04	421	19	7	HP:0009179
HumanPheno	Deviation of the hand or of fingers of the hand	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 MADD TWIST1	5.34e-04	564	19	8	HP:0009484
HumanPheno	Abnormality of mouth size	MBD5 SPEN MED13 RAI1 MADD TWIST1 SON	5.57e-04	425	19	7	HP:0011337
HumanPheno	Abnormality of the philtrum	FGF8 KAT6B SPEN TFAP2B MED13 RAI1 MADD TWIST1 SON	5.58e-04	726	19	9	HP:0000288
HumanPheno	Aplasia/hypoplasia involving bones of the upper limbs	SCUBE3 LMNB2 MBD5 KAT6B TFAP2B RAI1 TWIST1 SON	5.88e-04	572	19	8	HP:0006496
HumanPheno	Long fingers	LMNB2 SPIDR WNK1 SPEN TWIST1 SON	6.23e-04	306	19	6	HP:0100807
HumanPheno	Broad forehead	MBD5 TFAP2B RAI1 MADD TWIST1	7.36e-04	205	19	5	HP:0000337
HumanPheno	Abnormal esophagus physiology	SCUBE3 FGF8 MBD5 KAT6B WNK1 SPEN RAI1 MADD TWIST1 SON	7.52e-04	933	19	10	HP:0025270
HumanPheno	Radial deviation of finger	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1	7.67e-04	448	19	7	HP:0009466
HumanPheno	Aplasia involving bones of the extremities	SCUBE3 LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1 SON	7.81e-04	759	19	9	HP:0009825
HumanPheno	Aplasia/hypoplasia involving bones of the extremities	SCUBE3 LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1 SON	7.96e-04	761	19	9	HP:0045060
HumanPheno	Finger clinodactyly	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1	8.10e-04	452	19	7	HP:0040019
HumanPheno	Short palm	SCUBE3 MBD5 KAT6B RAI1	8.10e-04	118	19	4	HP:0004279
HumanPheno	Radial deviation of the hand or of fingers of the hand	LMNB2 MBD5 KAT6B SPEN TFAP2B RAI1 TWIST1	8.54e-04	456	19	7	HP:0009485
HumanPheno	Chronic constipation	LMNB2 MED13 RAI1 MADD	8.63e-04	120	19	4	HP:0012450
HumanPheno	Depressed nasal bridge	FGF8 KAT6B SPEN TFAP2B RAI1 MADD TWIST1 SON	9.32e-04	612	19	8	HP:0005280
HumanPheno	Flattened nasal bridge	FGF8 KAT6B SPEN TFAP2B RAI1 MADD TWIST1 SON	9.32e-04	612	19	8	HP:0000425
HumanPheno	Strabismus	CABP4 SCUBE3 FGF8 MBD5 SPEN TFAP2B MED13 RAI1 MADD TWIST1 SON	9.76e-04	1159	19	11	HP:0000486
HumanPheno	Bicoronal synostosis	SCUBE3 TWIST1	1.00e-03	13	19	2	HP:0011318
HumanPheno	Mesoaxial hand polydactyly	TFAP2B TWIST1	1.00e-03	13	19	2	HP:0006159
HumanPheno	Hypoplasia of the middle phalanges of the hand	MBD5 TFAP2B RAI1	1.02e-03	55	19	3	HP:0010240
HumanPheno	Short middle phalanx of finger	MBD5 TFAP2B RAI1	1.02e-03	55	19	3	HP:0005819
HumanPheno	Constipation	FGF8 LMNB2 MBD5 SPEN MED13 RAI1 MADD	1.05e-03	472	19	7	HP:0002019
HumanPheno	Abnormal upper lip morphology	FGF8 MBD5 KAT6B SPEN TFAP2B MED13 RAI1 MADD TWIST1 SON	1.13e-03	980	19	10	HP:0000177
HumanPheno	Extra-axial cerebrospinal fluid accumulation	LMNB2 MADD	1.17e-03	14	19	2	HP:0012510
HumanPheno	Depressed nasal ridge	FGF8 MBD5 SPEN TFAP2B	1.20e-03	131	19	4	HP:0000457
Domain	HABP4_PAI-RBP1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	7.46e-24	16	74	11	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	7.46e-24	16	74	11	IPR006861
Domain	USP_CS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	2.44e-17	66	74	12	IPR018200
Domain	USP_1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	5.21e-17	70	74	12	PS00972
Domain	UCH	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	6.25e-17	71	74	12	PF00443
Domain	USP_2	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	6.25e-17	71	74	12	PS00973
Domain	USP_3	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	7.48e-17	72	74	12	PS50235
Domain	USP_dom	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	7.48e-17	72	74	12	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	7.48e-17	72	74	12	IPR001394
Domain	PNMA	PNMA8A PNMA3 PNMA8B	9.63e-06	11	74	3	PF14893
Domain	PNMA	PNMA8A PNMA3 PNMA8B	9.63e-06	11	74	3	IPR026523
Domain	TF_homeodomain_male	PHTF2 PHTF1	1.55e-05	2	74	2	IPR021980
Domain	Phtf-FEM1B_bdg	PHTF2 PHTF1	1.55e-05	2	74	2	PF12129
Domain	RRM_1	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SRSF12	1.84e-05	208	74	7	PF00076
Domain	RRM	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SRSF12	2.41e-05	217	74	7	SM00360
Domain	RRM_dom	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SRSF12	3.22e-05	227	74	7	IPR000504
Domain	RRM	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SRSF12	3.50e-05	230	74	7	PS50102
Domain	-	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SRSF12	5.09e-05	244	74	7	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SRSF12	7.24e-05	258	74	7	IPR012677
Domain	BHLH	NPAS3 PHTF2 PHTF1 TWIST1 NPAS1	1.01e-04	117	74	5	PS50888
Domain	TF_AP2	TFAP2B TFAP2C	1.54e-04	5	74	2	IPR004979
Domain	TF_AP2_C	TFAP2B TFAP2C	1.54e-04	5	74	2	IPR013854
Domain	TF_AP-2	TFAP2B TFAP2C	1.54e-04	5	74	2	PF03299
Domain	RPR	SCAF8 U2SURP	4.27e-04	8	74	2	SM00582
Domain	CID	SCAF8 U2SURP	4.27e-04	8	74	2	PS51391
Domain	CID_dom	SCAF8 U2SURP	4.27e-04	8	74	2	IPR006569
Domain	PLipase_C_Pinositol-sp_Y	PLCH2 PLCE1	1.57e-03	15	74	2	IPR001711
Domain	EF-hand_like	PLCH2 PLCE1	1.57e-03	15	74	2	PF09279
Domain	PIPLC_Y_DOMAIN	PLCH2 PLCE1	1.57e-03	15	74	2	PS50008
Domain	PI-PLC_fam	PLCH2 PLCE1	1.57e-03	15	74	2	IPR001192
Domain	PLC_EF-hand-like	PLCH2 PLCE1	1.57e-03	15	74	2	IPR015359
Domain	PI-PLC-Y	PLCH2 PLCE1	1.57e-03	15	74	2	PF00387
Domain	PLCYc	PLCH2 PLCE1	1.57e-03	15	74	2	SM00149
Domain	PI-PLC-X	PLCH2 PLCE1	2.27e-03	18	74	2	PF00388
Domain	PLCXc	PLCH2 PLCE1	2.27e-03	18	74	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCH2 PLCE1	2.54e-03	19	74	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCH2 PLCE1	2.54e-03	19	74	2	IPR000909
Domain	PAS_fold_3	NPAS3 NPAS1	3.71e-03	23	74	2	IPR013655
Domain	PAS_3	NPAS3 NPAS1	3.71e-03	23	74	2	PF08447
Domain	PAS-assoc_C	NPAS3 NPAS1	4.04e-03	24	74	2	IPR000700
Domain	PAS	NPAS3 NPAS1	4.38e-03	25	74	2	PF00989
Domain	-	PLCH2 PLCE1	4.38e-03	25	74	2	3.20.20.190
Domain	PAS_fold	NPAS3 NPAS1	4.38e-03	25	74	2	IPR013767
Domain	PLC-like_Pdiesterase_TIM-brl	PLCH2 PLCE1	4.38e-03	25	74	2	IPR017946
Domain	PAC	NPAS3 NPAS1	4.73e-03	26	74	2	IPR001610
Domain	PAC	NPAS3 NPAS1	4.73e-03	26	74	2	SM00086
Domain	PAC	NPAS3 NPAS1	4.73e-03	26	74	2	PS50113
Domain	PHD	DPF3 KAT6B RAI1	5.31e-03	89	74	3	SM00249
Domain	Znf_PHD	DPF3 KAT6B RAI1	5.65e-03	91	74	3	IPR001965
Domain	ENTH_VHS	SCAF8 U2SURP	5.87e-03	29	74	2	IPR008942
Domain	ZF_PHD_2	DPF3 KAT6B RAI1	6.37e-03	95	74	3	PS50016
Domain	ZF_PHD_1	DPF3 KAT6B RAI1	6.55e-03	96	74	3	PS01359
Domain	PAS	NPAS3 NPAS1	7.11e-03	32	74	2	SM00091
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.14e-19	45	56	12	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.53e-12	221	56	13	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 MBD5 USP17L22 USP17L15 USP17L13 USP17L18	7.18e-12	299	56	14	M27574
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.98e-12	191	56	12	MM15289
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L21 PPP2R5E USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 FGF8 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.64e-11	318	56	14	MM15278
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 MBD5 USP17L22 USP17L15 USP17L13 USP17L18	2.18e-11	262	56	13	MM15286
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 MBD5 USP17L22 TFAP2B TFAP2C USP17L15 USP17L13 USP17L18	1.36e-04	1475	56	16	M19806
Pathway	WP_MRNA_PROCESSING	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SON SRSF12	3.80e-04	451	56	8	MM15946
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2B TFAP2C	5.48e-04	9	56	2	MM15509
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2B TFAP2C	6.83e-04	10	56	2	M27764
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2B TFAP2C	8.33e-04	11	56	2	MM15510
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 MBD5 USP17L22 TFAP2C USP17L15 USP17L13 USP17L18	8.36e-04	1389	56	14	MM15307
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2B TFAP2C	9.97e-04	12	56	2	M27765
Pathway	REACTOME_MRNA_SPLICING	SRSF4 SRSF6 U2SURP SRSF11 SRSF12	1.50e-03	212	56	5	M14033
Pathway	REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_GROWTH_FACTORS_AND_THEIR_RECEPTORS	TFAP2B TFAP2C	1.57e-03	15	56	2	M27766
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.67e-27	21	82	12	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.67e-27	21	82	12	8756639
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.67e-27	21	82	12	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.67e-27	21	82	12	14583620
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.67e-27	21	82	12	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.67e-27	21	82	12	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.06e-27	22	82	12	9154835
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.41e-26	33	82	13	20228807
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	15780755
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	20403174
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	19188362
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	17109758
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	11941478
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	14699124
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.28e-26	34	82	13	21448158
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.36e-26	24	82	12	8995226
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.62e-26	35	82	13	21239494
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.62e-26	35	82	13	16611142
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.66e-26	36	82	13	20147298
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	6.44e-26	25	82	12	21115691
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.71e-26	37	82	13	20228808
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.19e-25	26	82	12	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	6.38e-25	29	82	12	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.44e-21	50	82	12	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L21 MAGEB4 USP17L12 USP17L17 USP17L20 USP17L11 CABP4 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 PNMA3 USP17L13 USP17L18	5.26e-11	674	82	15	37196079
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	1.41e-08	119	82	7	28625976
Pubmed	A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).	SRSF4 SRSF6 SRSF11 SRSF12	2.02e-08	13	82	4	20516191
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	CDC42EP4 GTF3C1 FHOD1 SRSF11 LMNB2 ESPL1 WNK1 PDCD4 SON	2.79e-08	288	82	9	23383273
Pubmed	Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements.	SRSF4 SRSF6 SRSF11	2.51e-07	6	82	3	17361132
Pubmed	The SR protein family.	SRSF4 SRSF6 SRSF11	1.05e-06	9	82	3	19857271
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SRSF4 SRSF6 HIRIP3 GTF3C1 C16orf87 U2SURP SRSF11 NKTR LMNB2 SPEN TFAP2C RAI1 RSRC1 SON	1.88e-06	1294	82	14	30804502
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	SRSF4 SRSF6 U2SURP SRSF11 PDCD4 SON	4.47e-06	180	82	6	30110629
Pubmed	Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3.	SRSF4 SRSF6	5.49e-06	2	82	2	20685659
Pubmed	SCUBE3 (signal peptide-CUB-EGF domain-containing protein 3) modulates fibroblast growth factor signaling during fast muscle development.	SCUBE3 FGF8	5.49e-06	2	82	2	24849601
Pubmed	A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer.	SRSF4 SRSF6	5.49e-06	2	82	2	7651409
Pubmed	Phenotypic and molecular convergence of 2q23.1 deletion syndrome with other neurodevelopmental syndromes associated with autism spectrum disorder.	MBD5 RAI1	5.49e-06	2	82	2	25853262
Pubmed	Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered.	CXorf51A CXorf51B	5.49e-06	2	82	2	34415548
Pubmed	Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals.	PHTF2 PHTF1	5.49e-06	2	82	2	10729229
Pubmed	Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.	NPAS3 NPAS1	5.49e-06	2	82	2	28499489
Pubmed	Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.	FGF8 BARX1 TWIST1	8.39e-06	17	82	3	22411303
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PPP1R26 ARHGEF40 PCNX1 LMNB2 MBD5 ESPL1 WNK1 SPEN MED13 RAI1 MADD TJP3	1.07e-05	1105	82	12	35748872
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SRSF6 HIRIP3 GTF3C1 SCAF8 FHOD1 KAT6B ESPL1 SPEN MED13 SON	1.42e-05	774	82	10	15302935
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	PPP1R26 U2SURP MBD5 MED13 MADD	1.46e-05	130	82	5	12421765
Pubmed	Activation of TGF-β1 Pathway by SCUBE3 Regulates TWIST1 Expression and Promotes Breast Cancer Progression.	SCUBE3 TWIST1	1.64e-05	3	82	2	31742430
Pubmed	Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.	NPAS3 NPAS1	1.64e-05	3	82	2	15347806
Pubmed	A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens.	TFAP2B TFAP2C	1.64e-05	3	82	2	9758708
Pubmed	Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation.	TFAP2B TFAP2C	1.64e-05	3	82	2	11553286
Pubmed	TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.	TFAP2B TFAP2C	1.64e-05	3	82	2	35864973
Pubmed	Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.	TFAP2B TFAP2C	1.64e-05	3	82	2	32462520
Pubmed	The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.	NPAS3 NPAS1	1.64e-05	3	82	2	16172381
Pubmed	Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.	TFAP2B TFAP2C	1.64e-05	3	82	2	8661133
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SON	1.85e-05	347	82	7	16033648
Pubmed	AP-2δ is a crucial transcriptional regulator of the posterior midbrain.	FGF8 TFAP2B TFAP2C	2.80e-05	25	82	3	21858141
Pubmed	Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships.	FGF8 BARX1	3.28e-05	4	82	2	35618654
Pubmed	The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.	TFAP2B TFAP2C	3.28e-05	4	82	2	19115315
Pubmed	Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development.	TFAP2B TFAP2C	3.28e-05	4	82	2	9765260
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L15 USP17L13	3.28e-05	4	82	2	22984479
Pubmed	Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.	TFAP2B TFAP2C	3.28e-05	4	82	2	12749383
Pubmed	Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear.	BARX1 TWIST1	3.28e-05	4	82	2	28566723
Pubmed	Expression of Tfap2d, the gene encoding the transcription factor Ap-2 delta, during mouse embryogenesis.	TFAP2B TFAP2C	3.28e-05	4	82	2	12711551
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	SRSF4 SRSF6 NKTR KAT6B RAI1 SON	3.51e-05	259	82	6	30404004
Pubmed	Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts.	FGF8 TFAP2B TWIST1	3.55e-05	27	82	3	35781558
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SRSF4 SRSF6 GTF3C1 U2SURP SRSF11 NKTR RSRC1 SON SRSF12	4.70e-05	713	82	9	29802200
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PPP2R5E SCAF8 TRO SPEN MADD SON PLCE1	5.10e-05	407	82	7	12693553
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	BDP1 GTF3C1 TFAP2C	5.41e-05	31	82	3	23602572
Pubmed	Analysis of transcription factor AP-2 expression and function during mouse preimplantation development.	TFAP2B TFAP2C	5.47e-05	5	82	2	16672719
Pubmed	AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.	TFAP2B TFAP2C	5.47e-05	5	82	2	27984181
Pubmed	The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism.	TFAP2B TFAP2C	5.47e-05	5	82	2	12228234
Pubmed	Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.	TFAP2B TFAP2C	5.47e-05	5	82	2	12072434
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	SRSF4 SRSF6 U2SURP SRSF11 LMNB2 SPEN RSRC1 SON SRSF12	5.69e-05	731	82	9	29298432
Pubmed	Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.	TFAP2B TFAP2C	8.19e-05	6	82	2	12586840
Pubmed	Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis.	TFAP2B TFAP2C	8.19e-05	6	82	2	15569994
Pubmed	SR proteins: a conserved family of pre-mRNA splicing factors.	SRSF4 SRSF6	8.19e-05	6	82	2	1577277
Pubmed	AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle.	TFAP2B TFAP2C	8.19e-05	6	82	2	9918694
Pubmed	Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.	TFAP2B TFAP2C	8.19e-05	6	82	2	11694877
Pubmed	Transcription factor gene AP-2 gamma essential for early murine development.	TFAP2B TFAP2C	8.19e-05	6	82	2	11940672
Pubmed	A novel ciliopathic skull defect arising from excess neural crest.	FGF8 TWIST1	8.19e-05	6	82	2	27395007
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	U2SURP KAT6B WNK1 MADD	1.10e-04	104	82	4	9205841
Pubmed	NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.	NPAS3 NPAS1	1.14e-04	7	82	2	27782878
Pubmed	Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.	TFAP2B TFAP2C	1.14e-04	7	82	2	14572467
Pubmed	AP-2ε Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells.	TFAP2B TFAP2C	1.14e-04	7	82	2	29467543
Pubmed	Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage.	TFAP2B TFAP2C	1.52e-04	8	82	2	11319856
Pubmed	Folic acid prevents exencephaly in Cited2 deficient mice.	FGF8 TWIST1	1.52e-04	8	82	2	11823447
Pubmed	Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.	TFAP2B TFAP2C	1.52e-04	8	82	2	11744733
Pubmed	Global gene expression analysis of murine limb development.	FGF8 KAT6B TFAP2C TWIST1	1.74e-04	117	82	4	22174793
Pubmed	Ectoderm, endoderm, and the evolution of heterodont dentitions.	FGF8 BARX1	1.96e-04	9	82	2	20533405
Pubmed	Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition.	FGF8 BARX1	1.96e-04	9	82	2	9428417
Pubmed	Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.	FGF8 TWIST1	1.96e-04	9	82	2	16765933
Pubmed	Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.	TFAP2B TFAP2C	1.96e-04	9	82	2	12504852
Pubmed	Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.	SRSF4 SRSF6	1.96e-04	9	82	2	15009664
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	PPP2R5E NPAS3 SPIDR UCMA	2.24e-04	125	82	4	17062627
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CDC42EP4 SRSF4 SRSF6 HIRIP3 MED13 RSRC1 SON SRSF12	2.37e-04	695	82	8	23602568
Pubmed	Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.	SRSF4 SRSF6	2.44e-04	10	82	2	10983978
Pubmed	Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup.	FGF8 TWIST1	2.44e-04	10	82	2	10079236
Pubmed	Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos.	FGF8 TWIST1	2.44e-04	10	82	2	17325035
Interaction	CLK2 interactions	SRSF4 SRSF6 HIRIP3 SRSF11 NKTR SON SRSF12	1.05e-05	195	78	7	int:CLK2
Interaction	SRRM4 interactions	SRSF4 C16orf87 SRSF11 RSRC1	1.24e-05	37	78	4	int:SRRM4
Interaction	SRPK2 interactions	CDC42EP4 SRSF4 SRSF6 HIRIP3 U2SURP SRSF11 NKTR SPEN RSRC1 SON PNMA8B SRSF12	1.89e-05	717	78	12	int:SRPK2
Interaction	CD2BP2 interactions	ARHGEF40 SRSF4 SRSF6 U2SURP SRSF11 NKTR RSRC1	3.23e-05	232	78	7	int:CD2BP2
Interaction	ZFP62 interactions	CTCFL SRSF4 SRSF6 TWIST1 ZNF2	4.11e-05	99	78	5	int:ZFP62
Interaction	CITED4 interactions	TFAP2B TFAP2C PHTF1	7.05e-05	21	78	3	int:CITED4
Interaction	SRPK3 interactions	SRSF4 SRSF6 TRO U2SURP SRSF11 SON	9.49e-05	190	78	6	int:SRPK3
Interaction	DHX8 interactions	SRSF4 SRSF6 U2SURP SRSF11 NKTR SPEN SON	1.37e-04	292	78	7	int:DHX8
Interaction	CSNK2B interactions	PPP2R5E SRSF6 HIRIP3 DPF3 U2SURP NKTR RRAD MADD RSRC1 TJP3	1.44e-04	625	78	10	int:CSNK2B
Interaction	SRSF4 interactions	SRSF4 SRSF6 U2SURP SRSF11 NKTR SON SRSF12	1.62e-04	300	78	7	int:SRSF4
Interaction	ZCRB1 interactions	SRSF4 SRSF6 U2SURP PNMA8A FGF8	1.73e-04	134	78	5	int:ZCRB1
Interaction	ZSCAN25 interactions	SRSF4 SRSF6 PNMA8A ZNF2	1.85e-04	73	78	4	int:ZSCAN25
Interaction	AAMP interactions	SRSF6 WNK1 PDCD4 RSRC1	2.05e-04	75	78	4	int:AAMP
Interaction	CLK1 interactions	SRSF4 SRSF6 HIRIP3 SRSF11 SPEN SRSF12	2.06e-04	219	78	6	int:CLK1
Interaction	RBM19 interactions	SRSF4 SRSF6 PNMA8A FGF8 TWIST1 ZNF2	2.16e-04	221	78	6	int:RBM19
Interaction	FLT3 interactions	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	2.31e-04	318	78	7	int:FLT3
Interaction	SRSF7 interactions	SRSF4 SRSF6 GTF3C1 U2SURP SRSF11 NKTR SPEN SON	2.36e-04	425	78	8	int:SRSF7
Cytoband	4p16.1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.66e-22	79	82	13	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.84e-16	222	82	13	chr4p16
Cytoband	16q22	FHOD1 RRAD	4.21e-04	17	82	2	16q22
Cytoband	14q24.2	DPF3 PCNX1	9.21e-04	25	82	2	14q24.2
Cytoband	10q24	FGF8 PDCD4	1.80e-03	35	82	2	10q24
Cytoband	Xq27.3	CXorf51A CXorf51B	2.02e-03	37	82	2	Xq27.3
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF4 SRSF6 SRSF11 SRSF12	1.63e-08	12	45	4	737
GeneFamily	RNA binding motif containing	SRSF4 SRSF6 SCAF8 U2SURP SRSF11 SPEN SRSF12	8.86e-07	213	45	7	725
GeneFamily	Paraneoplastic Ma antigens	PNMA8A PNMA3 PNMA8B	2.34e-06	11	45	3	671
GeneFamily	Basic helix-loop-helix proteins	NPAS3 TWIST1 NPAS1	2.58e-03	110	45	3	420
GeneFamily	MAGE family	MAGEB4 TRO	4.45e-03	40	45	2	1136
GeneFamily	Phospholipases	PLCH2 PLCE1	4.90e-03	42	45	2	467
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	WNK1 SON	7.15e-03	51	45	2	870
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.00e-17	86	79	12	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.15e-16	112	79	12	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 RRAD USP17L22 USP17L15 USP17L13 USP17L18	1.86e-15	160	79	13	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.24e-07	647	79	12	MM981
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 C16orf87 PHTF2 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.50e-06	1072	79	14	MM1031
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 RRAD USP17L22 USP17L15 RSRC1 USP17L13 USP17L18	1.24e-05	1198	79	14	MM1062
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#3_top-relative-expression-ranked_1000	PRSS35 KAT6B TFAP2B TFAP2C TWIST1	1.35e-05	98	66	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k3
ToppCell	cellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NYAP2 TSPYL5 UCMA PNMA3 TWIST1	1.32e-05	182	74	5	bb7de0c93d8f59f13c990e425139b9348ca8027e
ToppCell	cellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular-Chondrocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NYAP2 TSPYL5 UCMA PNMA3 TWIST1	1.32e-05	182	74	5	507f095af4dff60f2c2b64d750477154084c3595
ToppCell	cellseq-Mesenchymal-Chondrocytic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NYAP2 TSPYL5 UCMA PNMA3 TWIST1	1.32e-05	182	74	5	88bd17c07bd8443a0ede4e9dc7bc9d1230b42211
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_CD8_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SRSF6 DAPK2 PCNX1 NKTR PDCD4	1.39e-05	184	74	5	cef3ee2a4a0af961aa3b4c92150d423e841ae8c1
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	BDP1 NKTR MBD5 WNK1 MED13	1.70e-05	192	74	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRSS35 TRO SCUBE3 RRAD PLCE1	1.75e-05	193	74	5	469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	BDP1 NKTR MBD5 WNK1 MED13	1.75e-05	193	74	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRSF6 SRSF11 NKTR MADD SON	1.79e-05	194	74	5	3a3ecedcdc7691cf21775818b598208fcb980c29
Drug	Mecamylamine hydrochloride [826-39-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A	DAPK2 ASTN2 PCNX1 LMNB2 WNK1 MAP3K12 PDCD4	1.71e-06	195	67	7	3525_DN
Drug	Heliotrine [303-33-3]; Down 200; 12.8uM; PC3; HT_HG-U133A	FAM204A ASTN2 SRSF11 LMNB2 SPIDR WNK1 PHTF1	1.83e-06	197	67	7	4277_DN
Drug	Cefotetan [69712-56-7]; Up 200; 7uM; PC3; HT_HG-U133A	DPF3 PLCH2 PHTF2 ASTN2 WNK1 MAP3K12 TFAP2C	1.89e-06	198	67	7	3997_UP
Drug	Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A	NKTR KAT6B WNK1 SPEN RSRC1 SON	1.41e-05	178	67	6	3998_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	NKTR KAT6B WNK1 SPEN RSRC1 SON	1.87e-05	187	67	6	4302_DN
Drug	Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	PHTF2 PCNX1 SRSF11 NKTR WNK1 SPEN	2.04e-05	190	67	6	4322_DN
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	CDC42EP4 SRSF4 SRSF6 NKTR KAT6B TFAP2C	2.23e-05	193	67	6	1051_DN
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	PCNX1 SRSF11 NKTR WNK1 SPEN RSRC1	2.30e-05	194	67	6	4312_DN
Drug	Etodolac [41340-25-4]; Down 200; 14uM; MCF7; HT_HG-U133A	U2SURP KAT6B TFAP2C PDCD4 MADD PHTF1	2.57e-05	198	67	6	7006_DN
Drug	Levopropoxyphene napsylate [5714-90-9]; Down 200; 7.4uM; MCF7; HT_HG-U133A	ADGRG2 PHTF2 PCNX1 WNK1 MAP3K12 PDCD4	2.65e-05	199	67	6	3543_DN
Drug	Naringin hydrate [11032-30-7]; Up 200; 6.6uM; PC3; HT_HG-U133A	ARHGEF40 NPAS3 ASTN2 FGF8 PCNX1 BARX1	2.72e-05	200	67	6	4605_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	SRSF4 HIRIP3 U2SURP LMNB2 KAT6B	1.19e-04	163	67	5	7285_DN
Drug	SAHA; Down 200; 10uM; PC3; HT_HG-U133A	SRSF4 HIRIP3 SCAF8 KAT6B PDCD4	1.66e-04	175	67	5	1220_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	SRSF4 HIRIP3 SCAF8 KAT6B PHTF1	1.75e-04	177	67	5	6340_DN
Drug	fisetin; Down 200; 50uM; PC3; HG-U133A	SRSF4 SPEN TFAP2C MED13 SON	1.80e-04	178	67	5	579_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SRSF4 HIRIP3 SCAF8 LMNB2 KAT6B	1.80e-04	178	67	5	1672_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	SRSF4 SCAF8 U2SURP LMNB2 KAT6B	1.85e-04	179	67	5	2105_DN
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A	NKTR KAT6B SPEN RSRC1 SON	1.85e-04	179	67	5	4585_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	SRSF4 HIRIP3 ADGRG2 SCAF8 KAT6B	1.90e-04	180	67	5	5981_DN
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	SCAF8 KAT6B SPEN MED13 SON	2.00e-04	182	67	5	3887_DN
Drug	Harmine hydrochloride [343-27-1]; Down 200; 16uM; MCF7; HT_HG-U133A	SCAF8 FHOD1 U2SURP PDCD4 SON	2.05e-04	183	67	5	2750_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	SRSF4 HIRIP3 SCAF8 KAT6B SON	2.16e-04	185	67	5	5882_DN
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	NKTR KAT6B WNK1 SPEN SON	2.16e-04	185	67	5	1673_DN
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	NKTR KAT6B SPEN RSRC1 SON	2.32e-04	188	67	5	6735_DN
Drug	N3RdUMP	BDP1 GTF3C1	2.36e-04	8	67	2	CID006439282
Drug	Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	PCNX1 SRSF11 NKTR WNK1 SPEN	2.38e-04	189	67	5	4304_DN
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	NKTR WNK1 SPEN TFAP2C SON	2.38e-04	189	67	5	1045_DN
Drug	Deltaline [6836-11-9]; Down 200; 7.8uM; PC3; HT_HG-U133A	PCNX1 SRSF11 NKTR WNK1 SPEN	2.44e-04	190	67	5	4306_DN
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT_HG-U133A	PCNX1 SRSF11 SPIDR WNK1 SPEN	2.44e-04	190	67	5	4307_DN
Drug	Lanatoside C [17575-22-3]; Down 200; 4uM; PC3; HT_HG-U133A	FHOD1 U2SURP ASTN2 MAP3K12 TJP3	2.50e-04	191	67	5	4328_DN
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	SRSF11 NKTR WNK1 SPEN RSRC1	2.50e-04	191	67	5	4269_DN
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A	FAM204A PCNX1 KAT6B WNK1 SPEN	2.50e-04	191	67	5	4283_DN
Drug	Flunixin meglumine [42461-84-7]; Down 200; 8.2uM; PC3; HT_HG-U133A	FAM204A PCNX1 NKTR WNK1 SPEN	2.50e-04	191	67	5	4273_DN
Drug	Y-27632; Up 200; 3uM; MCF7; HT_HG-U133A_EA	FHOD1 ASTN2 PCNX1 SRSF11 MAP3K12	2.62e-04	193	67	5	948_UP
Drug	Piromidic acid [19562-30-2]; Down 200; 13.8uM; HL60; HT_HG-U133A	FAM204A ARHGEF40 PHTF2 MAP3K12 TJP3	2.62e-04	193	67	5	2996_DN
Drug	Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	PHTF2 PCNX1 NKTR KAT6B TFAP2C	2.62e-04	193	67	5	4846_DN
Drug	Retrorsine [480-54-6]; Down 200; 11.4uM; MCF7; HT_HG-U133A	FHOD1 U2SURP PHTF2 PCNX1 PDCD4	2.68e-04	194	67	5	2784_DN
Drug	Norfloxacin [70458-96-7]; Down 200; 12.6uM; PC3; HT_HG-U133A	HIRIP3 U2SURP PCNX1 KAT6B PHTF1	2.68e-04	194	67	5	7283_DN
Drug	Famprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT_HG-U133A	ASTN2 PCNX1 NKTR WNK1 SPEN	2.68e-04	194	67	5	4309_DN
Drug	Letrozole [112809-51-5]; Down 200; 14uM; HL60; HT_HG-U133A	ARHGEF40 KAT6B WNK1 PDCD4 PHTF1	2.75e-04	195	67	5	2916_DN
Drug	2-propylpentanoic acid; Down 200; 200uM; PC3; HT_HG-U133A	HIRIP3 SCAF8 U2SURP PHTF2 PDCD4	2.75e-04	195	67	5	1214_DN
Drug	leukotoxin B (12,13-EODE); Up 200; 0.2uM; MCF7; HT_HG-U133A_EA	LMNB2 KAT6B MAP3K12 PDCD4 PHTF1	2.75e-04	195	67	5	1108_UP
Drug	Etomidate [33125-97-2]; Down 200; 16.4uM; MCF7; HT_HG-U133A	ADGRG2 ASTN2 PCNX1 WNK1 PDCD4	2.75e-04	195	67	5	3519_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A_EA	HIRIP3 PHTF2 NKTR KAT6B SON	2.75e-04	195	67	5	1053_DN
Drug	Tranexamic acid [1197-18-8]; Up 200; 25.4uM; PC3; HT_HG-U133A	ASTN2 SPIDR RRAD WNK1 TWIST1	2.75e-04	195	67	5	2085_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A	U2SURP PCNX1 SPIDR MADD RSRC1	2.75e-04	195	67	5	7101_UP
Drug	Minocycline hydrochloride [13614-98-7]; Down 200; 8uM; PC3; HT_HG-U133A	DPF3 PHTF2 MAP3K12 TFAP2C PLCE1	2.75e-04	195	67	5	5077_DN
Drug	Cisapride [81098-60-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A	HIRIP3 U2SURP MAP3K12 PDCD4 TJP3	2.75e-04	195	67	5	5305_DN
Drug	testosterone enanthate	SRSF6 ASTN2 NKTR RRAD WNK1 SPEN PDCD4 RSRC1	2.77e-04	575	67	8	ctd:C004648
Drug	Netilmicin sulfate [56931-57-2]; Down 200; 2.8uM; MCF7; HT_HG-U133A	ADGRG2 PCNX1 MAP3K12 PDCD4 PHTF1	2.81e-04	196	67	5	3524_DN
Drug	Amiprilose hydrochloride [60414-06-4]; Up 200; 11.8uM; PC3; HT_HG-U133A	DPF3 PHTF2 WNK1 TFAP2C MADD	2.81e-04	196	67	5	4000_UP
Drug	Edrophonium chloride [116-38-1]; Down 200; 19.8uM; HL60; HG-U133A	U2SURP NKTR SPEN MED13 SON	2.81e-04	196	67	5	2019_DN
Drug	Cefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; PC3; HT_HG-U133A	PCNX1 NKTR MAP3K12 TWIST1 TJP3	2.81e-04	196	67	5	2072_UP
Drug	Kanamycin A sulfate [25389-94-0]; Down 200; 6.8uM; MCF7; HT_HG-U133A	PPP1R26 U2SURP SRSF11 PDCD4 TJP3	2.81e-04	196	67	5	5686_DN
Drug	Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	ARHGEF40 DAPK2 PCNX1 TFAP2B TJP3	2.81e-04	196	67	5	6785_UP
Drug	Sulpiride [15676-16-1]; Up 200; 11.8uM; PC3; HG-U133A	ARHGEF40 HIRIP3 MAP3K12 TFAP2C TWIST1	2.88e-04	197	67	5	1887_UP
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A	HIRIP3 FHOD1 U2SURP SPEN MAP3K12	2.88e-04	197	67	5	7011_DN
Drug	Naproxen [22204-53-1]; Down 200; 17.4uM; PC3; HT_HG-U133A	NKTR KAT6B PDCD4 MADD PHTF1	2.88e-04	197	67	5	1828_DN
Drug	Flunixin meglumine [42461-84-7]; Up 200; 8.2uM; HL60; HT_HG-U133A	TRO DAPK2 PNMA8A FGF8 SPIDR	2.95e-04	198	67	5	2552_UP
Drug	clozapine; Down 200; 10uM; HL60; HT_HG-U133A	FAM204A CDC42EP4 U2SURP KAT6B SON	2.95e-04	198	67	5	1170_DN
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; PC3; HT_HG-U133A	NPAS3 SPIDR WNK1 TFAP2C NPAS1	2.95e-04	198	67	5	6637_UP
Drug	Betonicine [515-25-3]; Up 200; 25.2uM; PC3; HT_HG-U133A	NPAS3 SRSF11 NKTR SPIDR WNK1	2.95e-04	198	67	5	4301_UP
Drug	5286656; Down 200; 50uM; MCF7; HT_HG-U133A_EA	ASTN2 KAT6B SPEN TFAP2C PDCD4	2.95e-04	198	67	5	889_DN
Drug	Deptropine citrate [2169-75-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A	U2SURP PCNX1 SRSF11 SPIDR TFAP2C	2.95e-04	198	67	5	6523_DN
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A_EA	U2SURP PHTF2 NKTR WNK1 PDCD4	2.95e-04	198	67	5	1042_DN
Drug	Brinzolamide [138890-62-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	ARHGEF40 ADGRG2 TRO PHTF2 PLCE1	3.02e-04	199	67	5	3230_UP
Drug	rosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A	FHOD1 ASTN2 SPIDR KAT6B MAP3K12	3.02e-04	199	67	5	6950_DN
Drug	Pentamidine isethionate [140-64-7]; Up 200; 6.8uM; MCF7; HT_HG-U133A	ARHGEF40 ADGRG2 DAPK2 NPAS3 PCNX1	3.02e-04	199	67	5	4396_UP
Drug	Edrophonium chloride [116-38-1]; Up 200; 19.8uM; PC3; HG-U133A	PPP1R26 GTF3C1 NKTR MED13 RSRC1	3.02e-04	199	67	5	1936_UP
Drug	Racecadotril [81110-73-8]; Up 200; 10.4uM; PC3; HT_HG-U133A	ARHGEF40 DAPK2 U2SURP ASTN2 TJP3	3.09e-04	200	67	5	5755_UP
Drug	Iodipamide [606-17-7]; Down 200; 3.6uM; MCF7; HT_HG-U133A	LMNB2 SPIDR MAP3K12 TFAP2C TJP3	3.09e-04	200	67	5	5510_DN
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.50e-24	46	77	13	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 SON USP17L13 USP17L18	2.68e-23	69	77	14	DOID:1682 (implicated_via_orthology)
Disease	Salivary Gland Neoplasms	ESPL1 SPEN SON	2.55e-04	47	77	3	C0036095
Disease	sleep disorder (implicated_via_orthology)	TFAP2B TFAP2C	3.64e-04	11	77	2	DOID:535 (implicated_via_orthology)
Disease	insulin sensitivity measurement, body mass index	NYAP2 NPAS3	1.12e-03	19	77	2	EFO_0004340, EFO_0004471
Disease	waist-hip ratio	CTCFL NYAP2 PHTF2 ASTN2 PCNX1 BARX1 WNK1 TFAP2B RSRC1 PLCE1	1.29e-03	1226	77	10	EFO_0004343
Disease	descending aortic diameter	ARHGEF40 TWIST1 PLCE1	1.60e-03	88	77	3	EFO_0021788
Disease	Agents acting on the renin-angiotensin system use measurement	NYAP2 PCNX1 TFAP2B TWIST1 PLCE1	1.85e-03	335	77	5	EFO_0009931
Disease	colon adenocarcinoma (is_marker_for)	SRSF4 SRSF6	1.94e-03	25	77	2	DOID:234 (is_marker_for)
Disease	migraine disorder, diastolic blood pressure	ASTN2 PLCE1	1.94e-03	25	77	2	EFO_0006336, MONDO_0005277
Disease	FEV change measurement, response to zileuton	PRSS35 PCNX1	1.94e-03	25	77	2	EFO_0005921, EFO_0007676

Protein segments in the cluster

Peptide	Gene	Start	Entry
VDLRGKSKDRRSRSK	PRPF4B	296	Q13523
GFSRKSVRKARQKRS	PPP2R5E	16	Q16537
SRRKTGQTRREGARK	DCANP1	116	Q8TF63
TRGRGSKRVRGKTSK	BDP1	1841	A6H8Y1
TPRRTGKGNRRKKRA	ARHGEF40	371	Q8TER5
LRRAKSKNGGRSLRE	TFAP2C	266	Q92754
QRRSRSGVKGLKTTR	CXorf51A	36	A0A1B0GTR3
QRRSRSGVKGLKTTR	CXorf51B	36	P0DPH9
AASGKGRRTRKRKQT	CTCFL	576	Q8NI51
GKGRMALRRTSKRGS	ADGRG2	996	Q8IZP9
KSTTSRFRGKRRKRS	FAM204A	91	Q9H8W3
STSAGKRKRRSKSRG	ASTN2	376	O75129
VLRRAKSKNGGRSLR	TFAP2B	271	Q92481
KRKRLTRGRAKNTTS	RAI1	1536	Q7Z5J4
RKEKSRNAARSRRGK	NPAS1	46	Q99742
KKRGRKRRRINSSVT	KAT6B	1131	Q8WYB5
AGTRRRESLGKKAKR	RRAD	266	P55042
LVRRAGAKSRSRRKK	PNMA8A	231	Q86V59
ERKNRSSKKSSRKGR	HIRIP3	381	Q9BW71
SPRGKRRAKAGSRSR	MADD	156	Q8WXG6
KSKLRAREKRQRTRG	MAGEB4	6	O15481
PKRKNRTRGRARGSA	DPF3	166	Q92784
SATGRLGRSKRKRLE	LMNB2	426	Q03252
GTKAKKGRRSRTVFT	BARX1	136	Q9HBU1
SKARGKERLTGRARR	CCDC9B	326	Q6ZUT6
AHKSGRRRTGKKRAS	PCNX1	556	Q96RV3
KGRLLDRRSRSGKGR	PDCD4	96	Q53EL6
GRSLLRKSSSGRRSK	NYAP2	521	Q9P242
QRTKEKRVGGRSLRS	PANO1	46	I0J062
FTRKGRPRKGSKTRQ	FGF8	171	P55075
KRRGTASRGRGRARK	ESPL1	1416	Q14674
ASRGRGRARKGLSLK	ESPL1	1421	Q14674
RSKKERGLRGSRKRT	CABP4	41	P57796
IRRGRGRPKSASAKK	C16orf87	96	Q6PH81
AKFIKKRQSRASRRG	DAPK2	51	Q9UIK4
RKFRGSKRSQSVTRG	CDC42EP4	81	Q9H3Q1
RRGKTRHRKASAKGS	MAP3K12	541	Q12852
AYSRVRKRNRKSGKL	MBD5	1436	Q9P267
GRSSGNKKSKKRCRR	H2BK1	16	A0A2R8Y619
SRGNRKSLRRTLKSG	FHOD1	1131	Q9Y613
SRSRSGSRKRKHRKR	SCAF8	416	Q9UPN6
GSRKRKHRKRSRSRS	SCAF8	421	Q9UPN6
LKCDSSRKGKGRRAR	SCUBE3	526	Q8IX30
RSRKRGSKRDSKAGS	SRSF4	376	Q08170
LSTGGKRRRKLRKAA	PHTF2	196	Q8N3S3
VSKSGRKIKGRGTIR	NKTR	326	P30414
DGRRAKRRLRSSGKK	NKTR	751	P30414
SGSSRGKERKSRKSI	PLCE1	1686	Q9P212
SKAARGKKARRGRRL	PNMA8B	616	Q9ULN7
GVARAGSRGSRKRKR	PNMA3	396	Q9UL41
KKRRKRQKGGSASRR	NPAS3	601	Q8IXF0
GIKRSASAARRGKRV	PPP1R26	336	Q5T8A7
KGRSRSRSKGRKSRS	SRSF6	231	Q13247
NRARRKKSSARKFGL	MED13	1826	Q9UHV7
SRGRSRSKSLQKRSK	SRSF12	176	Q8WXF0
RRSRSRSPKKSGKKS	U2SURP	996	O15042
RKKSLSRDKGLRRRS	ZNF2	146	Q9BSG1
KNSKSKRGRSRNSRL	SPEN	2071	Q96T58
VRKDKGRQKTTRSRR	SPEN	2326	Q96T58
GRRSRSTSKTRDKKK	SRSF11	301	Q05519
RRRKLRKTVNGDGSR	PHTF1	161	Q9UMS5
RVKRGSRARKAATKA	TRO	336	Q12816
MPRGSRARGSKRKRS	SPIDR	1	Q14159
RNGRLVVGSFSRRKK	PLCH2	571	O75038
GGKKRRGSKRSRREA	PRSS35	196	Q8N3Z0
ASLRGRARRSKGKNK	USP17L18	506	D6R9N7
SSKGNKRGRTFRKTR	ZNF556	116	Q9HAH1
ASLRGRARRSKGKNK	USP17L5	506	A8MUK1
ASLRGRARRSKGKNK	USP17L21	506	D6R901
ASLRGRARRSKGKNK	USP17L13	506	C9JLJ4
ASLRGRARRSKGKNK	USP17L19	506	D6RCP7
SRKKGGRKSRSKSRS	RSRC1	36	Q96IZ7
RRRKKTRQGRRGGSC	nan	296	A8MV72
ASLRGRARRSKGKNK	USP17L12	506	C9JPN9
RLRGLRRGAKKTTQR	TJP3	576	O95049
RRRKKTRQGRRGGSC	nan	326	Q8N9G6
ASLRGRARRSKGKNK	USP17L24	506	Q0WX57
SGRRRRPTKSKGSKS	WNK1	2121	Q9H4A3
NRRVRGGKSQKRKRL	GTF3C1	1206	Q12789
ASLRGRARRSKGKNK	USP17L22	506	D6RA61
ASLRGRARRSKGKNK	USP17L15	506	C9J2P7
ASLRGRARRSKGKNK	USP17L17	506	D6RBQ6
SGKRGGRKRRSSRRS	TWIST1	31	Q15672
SRSKSRGRRSVSKEK	SON	1876	P18583
ASLRGRARRSKGKNK	USP17L20	506	D6RJB6
ASLRGRTRRSKGKNK	USP17L10	506	C9JJH3
NFLKRRGKRSPKSRD	UCMA	56	Q8WVF2
ASLRGRARRSKGKNK	USP17L11	506	C9JVI0
RGRKSSRAKNRGKGR	TSPYL5	6	Q86VY4